Use of SLIT in allergy practice: Is it ready for prime time? Stanley Fineman, MD, MBA Atlanta Allergy & Asthma Clinic AAIFNC, Feb 7, 2015
|
|
- Dustin King
- 6 years ago
- Views:
Transcription
1 Use of SLIT in allergy practice: Is it ready for prime time? Stanley Fineman, MD, MBA Atlanta Allergy & Asthma Clinic AAIFNC, Feb 7, 2015
2 Disclosures Speakers bureau/consultant: AZ, Genentech/Novartis, Meda, Merck, Mylan, Nestle, Teva Clinical research: Genentech, Meda, Teva
3 Learning objectives: Discuss historical use of SLIT. Understand logistics of offering SLIT in allergy practice. Evaluate risks and benefits of offering SLIT in allergy practice.
4 Outline Why offer SLIT? How do we mix? How do we charge? Pros & Cons Should you offer this to your patients?
5 Why offer SLIT
6 Dr Cox: AAAAI 2006
7
8
9
10
11 Dr Cox: AAAAI 2006
12 JACI 2011;127:S1-S55
13 JACI 2011;127:S1-S55
14 Clinical trials, irrespective of their design, of SLIT in the treatment of respiratory and food allergy in patients 18 years or younger were selected (29 of 56 articles). Quality of each trial and total quality of compounded evidence was analyzed with the Grading of Recommendations Assessment, Development and Evaluation system. Annals Allergy Asthma Immunol 2013;110:
15 What did they report? Of 56 articles, 29 met the inclusion criteria. Evidence is robust for the pre-coseasonal tablet and drop grass pollen SLIT efficacy in allergic rhinitis and for seasonal allergic asthma For house dust mite (HDM) SLIT in asthma, there is highquality evidence for medication reduction while maintaining symptom control Evidence for HDM SLIT efficacy in allergic rhinitis is of moderate-low quality. There is moderate evidence for efficacy of dual grass pollen and HDM SLIT after 12 months of treatment and 1 year after discontinuation in AR No anaphylaxis was found among 2469 treated children Some evidence for Alternaria SLIT efficacy is appearing Annals Allergy Asthma Immunol 2013;110:
16 March 2013
17
18
19
20
21 JACI Pract 2014;2:144-9
22
23 What is the trend now?
24 Specialty Distribution by Type of Immunotherapy Provided Annals Allergy 2014;112: Subcutaneous N=199; Sublingual N=62. These Ns represent those providers who provide IT (IT17a) and who did not indicate that they had no patients on subcutaneous (IT18a) or sublingual (IT19a) IT. Ns by specialty are shown in parentheses with subcutaneous first. 24
25 Annals Allergy 2013;110:
26 Annals Allergy 2013;110:
27 Are pts more likely to use SLIT?
28 Children s compliance with allergen immunotherapy according to administration routes. Panjo, et al; Letter JACI JACI 2005;116:
29 Children s compliance with allergen immunotherapy according to administration routes. Panjo, et al; Letter JACI JACI 2005;116:
30 More Italian experience JACI 2010; 126:668-9
31 Persistence with Specific Immunotherapy (SCIT & SLIT) Among AR Patients in A US Allergy Practice Anolik et al AAAAI San Antonio 2013 Methods: Data from a retrospective chart review study of allergic rhinitis patients managed at a group allergy practice in the US initiating subcutaneous immunotherapy (SCIT) or sublingual immunotherapy (SLIT) from were analyzed.
32 Persistence with SCIT & SLIT with AR pts Anolik et al: Results A total of 3,182 patients were identified, 78% chose SCIT and 22% chose SLIT Only 32.5% of patients completed treatment; 35% of SCIT and 23.7% of SLIT patients Median time on therapy was longer for SCIT patients (3.6 years) versus SLIT patients (2.6 years) Similar patterns were seen among children AAAAI 2013
33 Review of previous studies: 55%-82% of pts abandon SLIT before completing recommended course (3-5 year) Recommend: Communication improvement Educational tools F/U visits Telecommunication techniques JACIinPract 2014;2:
34 JACIinPract 2014;2:
35 JACIinPract 2014;2:
36 How do we mix?
37 Logistics Glass dropper bottles w/ metered dose pump Delivers 0.05 ml per drop (50 mcl) Bottles have 15 ml capacity Fill to 8 ml Sterile 50% glycerine used as diluent Maintenance dose if 0.25 ml (5 drops) per day Each 8 ml maintenance bottle lasts a month
38
39
40 Logistics, continued Start with two build-up vials and one maintenance vial Build-up vials are 10-fold serial dilutions of the maintenance concentration (ie 1:10 w/v & 1:100 w/v) Dose in the mornings Hold drops under tongue for 2-3 minutes Patient may swallow or spit after 2 minutes Do not eat or drink for 5-10 minutes after dosing
41 Treatment Schedule Maintenance vials: 5 drops/ day Adjust dose if more than 4 doses are missed
42
43 Costs of Extracts at AAAC Extract Cost/50 ml Amount in vial Cost in Vial HDM mix, 10,000 AU $143 1 ml $2.86 Cat 10, 000 BAU $ ml $5.46 Birch 1:20 w/v $ ml $2.33 Oak 1:20 w/v $93 1 ml $1.86 Mixed Ragweed 1:20 $ ml $2.79 Bermuda, 10,000 BAU $ ml $1.20 Timothy 100,000 BAU $ $1.20 Diluent 50% glycerin $2 Max total cost $18.00
44 How many pts have ordered SLIT? April 2013 Dec 2013 Jan 2014 Dec pts 86 pts
45
46 Pros & Cons of SLIT Safety Fewer systemic reactions than SCIT Some local/oral reactions Efficacy Many studies showing efficacy Some question about multiple allergen efficacy Convenience Not an injection Administered at home
47 Pros & Cons of SLIT Not FDA-approved for drops No clear-cut established protocol Costs for patient all out of pocket for drops Tablets covered as a pharmacy benefit Pts need to be trained to recognize and treat anaphylaxis Epinephrine autoinjector for all patients
48 Outline Why offer SLIT? How do we mix? How do we charge? Pros & Cons Should you offer this to your patients?
49 Which way is best for you?
e. Elm Correct Question 2 Which preservative/adjuvant has the greatest potential to breakdown immunotherapy because of protease activity? a.
Allergen Immunotherapy Practical Quiz Question 1 Which of the following pollens shows cross-reactivity with birch pollen? a. Alder b. Olive c. Ash d. Black walnut e. Elm Question 2 Which preservative/adjuvant
More informationIntroduction. Methods. Results 12/7/2012. Immunotherapy in the Pediatric Population
12/7/212 Introduction Immunotherapy in the Pediatric Population Michael S. Blaiss, MD Clinical Professor of Pediatrics and Medicine University of Tennessee Health Science Center Memphis, Tennessee Allergen
More informationQuick Guide: SLIT Protocol
Quick Guide: SLIT Protocol Mixing allergy drops in your dermatology practice. Countless Pet Allergies. One Solution. ACTTallergy.com V009v2 You have a choice for your allergy products with the ACTT Allergy
More informationAssessing the Relative Risks of Subcutaneous and Sublingual Allergen Immunotherapy
Assessing the Relative Risks of Subcutaneous and Sublingual Allergen Immunotherapy Tolly Epstein, MD, MS Assistant Professor of Clinical Medicine Division of Immunology, Allergy & Rheumatology University
More informationSpeaking the Same Language: Grading System for Subcutaneous Immunotherapy Systemic Reaction World Allergy Organization Symposium Immunotherapy &
Speaking the Same Language: Grading System for Subcutaneous Immunotherapy Systemic Reaction World Allergy Organization Symposium Immunotherapy & Biologics 2012 Chicago Linda Cox, MD, FAAAAI Linda Cox,
More informationNew Frontiers in Allergen Immunotherapy
New Frontiers in Allergen Immunotherapy Bryan Martin, DO, MMAS, FACP. FACOI, FAAAI, DFACAAI President, The American College of Allergy, Asthma & Immunology Emeritus Professor of Medicine and Pediatrics
More informationWhich Factors Might Enhance Safety of Immunotherapy in Your Clinic?
Which Factors Might Enhance Safety of Immunotherapy in Your Clinic? David I. Bernstein MD FAAAI Professor of Medicine and Environmental Health Division of Immunology and Allergy University of Cincinnati
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Oral Immunotherapy Agents Page 1 of 13 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Oral Immunotherapy Agents Prime Therapeutics will review Prior Authorization
More informationAllergen Immunotherapy: An Update
Allergen Immunotherapy: An Update Susan Waserman MSc MDCM FRCPC Professor of Medicine Division of Clinical Allergy and Immunology CTS Calgary April 26, 2014 Presenter Disclosure Presenter: Dr Susan Waserman
More informationDisclosures. Sublingual Immunotherapy for Allergic Disease. Allergy Definition. Learning Objectives. Putting Allergies in Perspective
38 th National Conference on Pediatric Health Care March 16-19, 2017 Sublingual for Allergic Disease Zero, Zip, None Disclosures Kevin Letz DNP, MSN, MBA, CEN, CNE, FNP C, PCPNP BC, ANP BC, FAANP Learning
More informationSLIT: Review and Update
SLIT: Review and Update Disclosure Speaker: ISTA Pharmaceuticals Speaker: GlaxoSmithKline Allergen IT - Evidence Based Evaluation: Rescue Medications Meta-analysis Disease IT # of Patients Rescue Medication
More informationExpert Roundtable on Sublingual Immunotherapy
Expert Roundtable on Sublingual Immunotherapy FACULTY Linda Cox, MD Clinical Associate Professor, Nova Southeastern University Thomas Casale, MD Professor of Medicine, University of South Florida Peter
More informationAEROALLERGEN IMMUNOTHERAPY FOR ALLERGIC RHINITIS
AEROALLERGEN IMMUNOTHERAPY FOR ALLERGIC RHINITIS Persia Pourshahnazari MD, FRCPC Clinical Immunology and Allergy November 4, 2018 OBJECTIVES Review indications and evidence for aeroallergen immunotherapy
More informationThe Only Choice that Leaves You in Complete Control
USDA Approved for Sublingual Administration Not Just Another Choice for SLIT The Only Choice that Leaves You in Complete Control GREER Extracts and GREER Pharmacy Custom Prescript ions TM Real Choices.
More informationPractical Course Allergen Immunotherapy (AIT) How to be effective. Michel Dracoulakis HSPE- FMO São Paulo-SP Brazil
Practical Course Allergen Immunotherapy (AIT) How to be effective Michel Dracoulakis HSPE- FMO São Paulo-SP Brazil Allergen immunotherapy - beginning Dunbar almost died with first inoculation 1911 Noon
More informationINVESTIGATIONS & PROCEDURES IN PULMONOLOGY. Immunotherapy in Asthma Dr. Zia Hashim
INVESTIGATIONS & PROCEDURES IN PULMONOLOGY Immunotherapy in Asthma Dr. Zia Hashim Definition Involves Administration of gradually increasing quantities of specific allergens to patients with IgE-mediated
More informationODACTRA House Dust Mite (Dermatophagoides farina & Dermatophagoides pteronyssinus) allergen extract sublingual tablet
pteronyssinus) allergen extract sublingual tablet Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan.
More informationAccelerated Immunotherapy Schedules: More Convenient? Just As Safe?
Accelerated Immunotherapy Schedules: More Convenient? Just As Safe? David A. Khan, MD Professor of Medicine Allergy & Immunology Training Program Director Division of Allergy & Immunology University of
More informationAssociate Professor Rohan Ameratunga Immunologist & Allergist, Auckland
Associate Professor Rohan Ameratunga Immunologist & Allergist, Auckland Update on desensitisation Associate Professor Rohan Ameratunga GLORIA Module 4: Allergen Specific Immunotherapy A New Zealand perspective
More informationRagwitek. Ragwitek (Short Ragweed Pollen Allergen Extract) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.20.05 Subject: Ragwitek Page: 1 of 5 Last Review Date: December 8, 2017 Ragwitek Description Ragwitek
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Oral Immunotherapy Agents Page 1 of 14 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Oral Immunotherapy Agents (Grastek, Oralair, Ragwitek ) Prime Therapeutics
More informationPharmacy Coverage Guidelines are subject to change as new information becomes available.
RAGWITEK (Short Ragweed Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Pharmacy Coverage Guideline
More informationAllergy Immunotherapy: A New Role for the Family Physician
Allergy Immunotherapy: A New Role for the Family Physician Louis Kuritzky MD Clinical Assistant Professor Emeritus Department of Community Health and Family Medicine College of Medicine University of Florida,
More informationImmunotherapy. Chris Doyle Consultant Nurse Respiratory & Allergy Alder Hey Childrens NHS FT. October 18 th 2014
Immunotherapy Chris Doyle Consultant Nurse Respiratory & Allergy Alder Hey Childrens NHS FT Chris.doyle@alderhey.nhs.uk October 18 th 2014 What exactly is Immunotherapy? Medical procedure that uses controlled
More informationTen-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis ABSTRACT
Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis ABSTRACT RATIONALE: Juniper species are major spring allergens in the southwestern USA. We previously reported a study of sublingual
More informationGLORIA Module 4: Allergen Specific Immunotherapy Its safe use: A New Zealand perspective
Update on desensitisation Associate Professor Rohan Ameratunga GLORIA Module 4: Allergen Specific Immunotherapy Its safe use: A New Zealand perspective Procedure Allergen immunotherapy is the administration
More informationThe Current Status of Sublingual Immunotherapy
The Current Status of Sublingual Immunotherapy Harold S. Nelson, MD Professor of Medicine National Jewish Health and University of Colorado Denver School of Medicine Denver, Colorado Disclosure: Harold
More informationRECOMMENDATIONS FOR APPROPRIATE SLIT TRIALS
RECOMMENDATIONS FOR APPROPRIATE SLIT TRIALS Giovanni Passalacqua Allergy & Respiratory Diseases Dept.Internal MedicineIRCCS S.Martino IST University of Genoa ITALY CHICAGO-WAO-2013 ISHIZAKA NOON UK CSM
More informationGrastek. Grastek (timothy grass pollen allergen extract) Description. Section: Prescription Drugs Effective Date: January 1, 2018
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.20.07 Subject: Grastek Page: 1 of 5 Last Review Date: December 8, 2017 Grastek Description Grastek (timothy
More informationOralair (Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass Mixed Pollens Allergen Extract)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Oralair Page: 1 of 5 Last Review Date: November 30, 2018 Oralair Description Oralair (Sweet Vernal,
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Grastek, Oralair, Ragwitek) Reference Number: CP.CPA.111 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Commercial Revision Log See Important Reminder at the end of
More informationRagwitek. Ragwitek (Short Ragweed Pollen Allergen Extract) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.08.34 Subject: Ragwitek Page: 1 of 5 Last Review Date: December 3, 2015 Ragwitek Description Ragwitek
More informationAllergen immunotherapy: from EBM to doctors and patients need
Allergen immunotherapy: from EBM to doctors and patients need Moscow, Marriott Hotel February 28th, 2019 Dr. Franco Frati Medical Department Milan, Italy From the recognition of the pollen to in vivo tests
More informationWhat are Allergy shots / SCIT?
Allergy diagnosis must be made accurately with correct history and tests including the skin prick test and the blood test like immunocap / Phadiatop study. This once made will help decide the dose and
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Policy Number: 2.01.17 Last Review: 7/2014 Origination: 7/2006 Next Review: 7/2015 Policy Blue Cross and Blue Shield of Kansas City
More informationAllergen Immunotherapy in Asthma: Now and in the Future
Allergen Immunotherapy in Asthma: Now and in the Future Young-Il Koh, M.D. Chonnam National University Medical School, Gwangju, Korea 2017-03-25 CHONNAM NATIONAL UNIVERSITY MEDICAL SCHOOL 1 Management
More informationMedical Policy An Independent Licensee of the Blue Cross and Blue Shield Association
Sublingual Immunotherapy as a Technique Page 1 of 24 Medical Policy An Independent Licensee of the Blue Cross and Blue Shield Association Title: Sublingual Immunotherapy as a Technique of Allergen- Specific
More informationThe Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy
The Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy 1 Anergis Focus on Allergy Immunotherapy (AIT) High Medical Need and Patient Demand 500 M allergic patients - fastest growing chronic condition
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Policy Number: 2.01.17 Last Review: 7/2018 Origination: 7/2006 Next Review: 7/2019 Policy Blue Cross and Blue Shield of Kansas City
More informationAs you begin this build-up phase there are several factors to keep in mind concerning your treatment:
SLIT IMMUNOTHERAPY INSTRUCTIONS David R. Scott, M.D./William A. Scott, M.D. Congratulations on beginning your new sublingual immunotherapy (SLIT) prescription! The initial 30 doses are advancement doses.
More informationFormat. Allergic Rhinitis Optimising Mananagement. Degree of Quality of life Restriction in the Allergic Patient. The allergy epidemic:
Format Allergic Rhinitis Optimising Mananagement Dr Dominic Mallon FRACP FRCPA Clinical Immunologist and Allergist Fiona Stanley Hospital Impact of allergic rhinitis Diagnosis and management of allergic
More informationWe improve quality of life by preventing and curing allergy
We improve quality of life by preventing and curing allergy SEB Enskilda Nordic Small & Mid Cap Seminar 2008 Jens Bager, President & CEO ALK-Abelló a fast growing pharmaceutical company Global pharmaceutical
More informationCorporate Medical Policy Allergy Immunotherapy (Desensitization)
Corporate Medical Policy Allergy Immunotherapy (Desensitization) File Name: Origination: Last CAP Review: Next CAP Review: Last Review: allergy_immunotherapy 7/1979 11/2017 11/2018 11/2017 Description
More informationPresentation of ALK London, 24 May 2011 UBS GLOBAL SPECIALTY PHARMACEUTICALS CONFERENCE : LONDON : 24 MAY 2011
Presentation of ALK London, 24 May 2011 1 ALK pharma specialist - treatment, prevention and diagnosis of allergies World leader in allergy immunotherapy ~ 33% global market share Expanding Base Business
More informationThe only sublingual grass allergy immunotherapy tablet with a mixed pollens allergen extract from 5 grasses 1
The only sublingual grass allergy immunotherapy tablet with a mixed pollens allergen extract from 5 grasses 1 An important immunotherapy option for patients with grass allergies Effective during the first
More informationALK-Abelló A/S. Click View,Header and Footer to change this text to filename and department name
ALK-Abelló A/S June 25, 2008 Click View,Header and Footer to change this text to filename and department name 1 Changing the way we treat allergy Piper Jaffray 19th Annual Health Care Conference, New York
More informationType of intervention Treatment. Economic study type Cost-effectiveness analysis.
Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma Berto P, Bassi M, Incorvaia C, Frati F, Puccinelli P, Giaquinto C, Cantarutti L, Ortolani C Record Status This
More informationCoverage Criteria: Express Scripts, Inc. monograph dated 03/03/2010
BENEFIT DESCRIPTION AND LIMITATIONS OF COVERAGE ITEM: PRODUCT LINES: COVERED UNDER: DESCRIPTION: CPT/HCPCS Code: Company Supplying: Setting: Xolair (omalizumab) Commercial HMO/PPO/CDHP HMO/PPO/CDHP: Rx
More informationPrevalence of Fungal Allergy in Patients with Allergic Rhinosinusitis
Prevalence of Fungal Allergy in Patients with Allergic Rhinosinusitis Kyle Kennedy, M.D. Karen Calhoun,, M.D. June 5, 1999 Hypothesis Subset of patients with signs and symptoms of allergic rhinosinusitis
More informationImmunoCAP. Specific IgE blood test
Allergy- Specific IgE blood test provides clinicians with an accurate and convenient method of helping to rule in or rule out allergy in patients with allergy-like symptoms. Allergy- Positive About Allergy-
More informationNew Test ANNOUNCEMENT
March 2003 W New Test ANNOUNCEMENT A Mayo Reference Services Publication Pediatric Allergy Screen
More informationA world leader in allergy immunotherapy. Jefferies Global Healthcare Conference, London : 19 November 2014 : Flemming Pedersen, CFO & EVP
A world leader in allergy immunotherapy ALK at a glance Leading allergy immunotherapy (AIT) specialist AIT: Treats the root cause of allergy Products in all areas of AIT ALK has 33% of the global AIT market
More informationAllergen Immunotherapy
Allergen Immunotherapy ASCIA EDUCATION RESOURCES (AER) PATIENT INFORMATION Allergen immunotherapy switches off allergy Although medications available for allergy are usually very effective, they do not
More informationIncrease in revenues in line with full-year targets (+1.2%) Very strong growth of Oralair exc. USA (+26%) H revenues and results - 24 July 2014
Increase in revenues in line with full-year targets (+1.2%) Very strong growth of Oralair exc. USA (+26%) ( ) H1 2014 revenues and results - 24 July 2014 Forward-looking statement This presentation contains
More informationMedical Policy An Independent Licensee of the Blue Cross and Blue Shield Association
Oral Immunotherapy Agents Page 1 of 15 Medical Policy An Independent Licensee of the Blue Cross and Blue Shield Association Title: Oral Immunotherapy Agents (Grastek, Oralair, Ragwitek ) Prime Therapeutics
More informationAllergen Immunotherapy and Asthma. Linda Cox, MD, FAAAI ASCIA 2013 Meeting
Allergen Immunotherapy and Asthma Linda Cox, MD, FAAAI ASCIA 2013 Meeting Allergen Immunotherapy and Asthma Overview: burden/prevalence of asthma and allergic disease Allergen immunotherapy and asthma:
More informationAllergy Therapeutics. Corporate Presentation. Proactive Investors 28th January 2016 Ian Postlethwaite, Finance Director
Allergy Therapeutics Corporate Presentation January 2016 Introduction We treat people with Allergic disorders Focused on the moderate to severe patients Providing treatments that cure the disease, not
More informationEar, Nose & Throat (ENT) - Head & Neck Surgery. Allergic Rhinitis (Sinus)
Ear, Nose & Throat (ENT) - Head & Neck Surgery Allergic Rhinitis (Sinus) The Department of Ear, Nose & Throat (ENT) - Head & Neck Surgery provides a wide range of surgical services for adult patients with
More informationFace to Face on LAIS Mechanism of action and clinical experiences
Kazan, 14-17 May 2014 Face to Face on LAIS Mechanism of action and clinical experiences Mario di Gioacchino Dept. of Medicine and Ageing Science University of Chieti. Italy Enrico Compalati Allergy & Respiratory
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Policy Number: 2.01.17 Last Review: 7/2017 Origination: 7/2006 Next Review: 7/2018 Policy Blue Cross and Blue Shield of Kansas City
More informationAllergies & Hypersensitivies
Allergies & Hypersensitivies Type I Hypersensitivity: Immediate Hypersensitivity Mediated by IgE and mast cells Reactions: Allergic rhinitis (hay fever) Pollens (ragweed, trees, grasses), dust mite feces
More informationALK-Abelló Research & Development. Henrik Jacobi MD, EVP Research & Development
ALK-Abelló Research & Development Henrik Jacobi MD, EVP Research & Development Agenda Latest news on GRAZAX 3rd year data from long-term study (GT-08) Effect on asthma symptoms in children (GT-12) Status:
More informationAbstract and Introduction.
Sublingual Immunotherapy in Children: The Recent Experiences Nicole Pleskovic, Ashton Bartholow, David P. Skoner Curr Opin Allergy Clin Immunol. 2014;14(6):582-590. www.medscape.com Abstract and Introduction
More informationThe Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy
The Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy 1 Anergis Focus on Allergy Immunotherapy (AIT) High Medical Need and Patient Demand 500 M allergic patients - fastest growing chronic condition
More informationLatest advances in the management of childhood allergic rhinitis
Latest advances in the management of childhood allergic rhinitis Jason Y K Chan Assistant Professor Department of Otorhinolaryngology, Head & Neck Surgery The Chinese University of Hong Kong Disclosures
More informationControlled Studies of Environmental Allergen Remediation in U.S. Homes: Cockroach Allergen
Controlled Studies of Environmental Allergen Remediation in U.S. Homes: Cockroach Allergen Samuel J. Arbes, Jr. Staff Scientist and Epidemiologist Laboratory of Respiratory Biology Outline for Today s
More informationPreventive effect of AIT over the atopic march
Preventive effect of AIT over the atopic march Susanne Halken, Professor, Pediatric Allergist Hans Christian Andersen Children s Hospital Odense University Hospital, DK Type Disclosure In relation to this
More informationLecture objectives. Definition. Allergen Immunotherapy for Asthma. Effects of Immunotherapy 12/9/2012. Dana V. Wallace, MD. Disclosure Statement
Disclosure Statement Dana V. Wallace, MD Dana V. Wallace, MD Assistant Clinical Professor Nova Southeastern University Davie, Florida drdanawallace@gmail.com I participate in the following Speaker s Bureau
More informationAllergy Testing and Practical Mitigation Measures
Allergy Testing and Practical Mitigation Measures Carol T Cady, MD, PhD Big Sky Pulmonary Conference March 24th, 2012 Overview of Allergies and Mitigation The human component The environmental component
More informationKevin Letz DNP, MSN, MBA, RN, CEN, CNE, FNP-C, PNP-BC, ANP-BC
Kevin Letz DNP, MSN, MBA, RN, CEN, CNE, FNP-C, PNP-BC, ANP-BC Kevin Letz, DNP An allergic reaction is the body s immune system reacting inappropriately to a foreign substance, such as pollen. The immune
More informationSecondary prevention of allergic disease. Dr Adam Fox United Kingdom
Secondary prevention of allergic disease Dr Adam Fox United Kingdom Disclosures Lecture fees: Danone, Mead Johnson, ALK-Abello, Stallergenes, Allergy Therapeutics Industry-sponsored grant: Danone, ALK-Abello
More informationUNDERSTANDING ALLERGY IMMUNOTHERAPY
UNDERSTANDING ALLERGY IMMUNOTHERAPY Provide Allergy Patients Another Option for Relief How many of your patients suffer from allergies? ALLERGIES ARE A BURDENSOME CONDITION FOR MANY PEOPLE IN THE US. In
More informationALLERGEN IMMUNOTHERAPY FOR THE TREATMENT OF ALLERGIC RHINITIS AND/OR ASTHMA
ALLERGEN IMMUNOTHERAPY FOR THE TREATMENT OF ALLERGIC RHINITIS AND/OR ASTHMA FINAL SYSTEMATIC REVIEW REPORT September 2015 Systematic Review Team: George A. Wells, Jesse Elliott, Shannon Kelly, Amy Johnston,
More informationNew Approaches to Immunotherapy
New Approaches to Immunotherapy Harold S. Nelson, MD Professor of Medicine National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, USA Faculty Disclosure Harold S. Nelson,
More informationDiscover the connection
Jill is about to have asthma symptoms and she won t know why. Timothy grass ASTHMA Dog dander House dust mites Underlying allergies affect asthma Discover the connection Specific IgE blood testing helps
More informationLeading R&D pipeline with proven technology. Partners. Injection and drop-based allergy immunotherapy products
ALK at a glance The leading allergy immunotherapy specialist 33% of global allergy immunotherapy market Leading R&D pipeline with proven technology Strategic partnerships to globalise SLIT- tablet portfolio
More informationIMMUNOTHERAPY IN ALLERGIC RHINITIS
Rhinology research Chair Weekly Activity, King Saud University IMMUNOTHERAPY IN ALLERGIC RHINITIS E V I D E N C E D - B A S E O V E R V I E W O F T H E R U L E O F I M M U N O T H E R A P Y I N A L L E
More informationResearch Article Quality of Life Improvement with Sublingual Immunotherapy: A Prospective Study of Efficacy
Hindawi Publishing Corporation Journal of Allergy Volume 2012, Article ID 253879, 6 pages doi:10.1155/2012/253879 Research Article Quality of Life Improvement with Sublingual Immunotherapy: A Prospective
More informationAllergic rhinitis is a common worldwide disease that
Safety and efficacy of radioallergosorbent test-based allergen immunotherapy in treatment of perennial allergic rhinitis and asthma KIAN HIAN YEOH, MD, DE YUN WANG, MD, PHD, and BRUCE R. GORDON, MD, Singapore,
More informationjournal Current status of sublingual immunotherapy in the United States Shelby Elenburg and Michael S Blaiss *
Elenburg and Blaiss World Allergy Organization Journal 2014, 7:24 journal REVIEW Open Access Current status of sublingual immunotherapy in the United States Shelby Elenburg and Michael S Blaiss * Abstract
More informationClinical Implications of Asthma Phenotypes. Michael Schatz, MD, MS Department of Allergy
Clinical Implications of Asthma Phenotypes Michael Schatz, MD, MS Department of Allergy Definition of Phenotype The observable properties of an organism that are produced by the interaction of the genotype
More informationSublingual immunotherapy (SLIT) vs. Subcutaneous immunotherapy (SCIT) Canonica G.W. Personalized Medicine Clinic Asthma & Allergy.
Sublingual immunotherapy (SLIT) vs. Subcutaneous immunotherapy (SCIT) Canonica G.W. Personalized Medicine Clinic Asthma & Allergy Milano Italy President President G.Walter CANONICA DISCLOSURE OF INTERESTS
More informationWILLIAM B. COBB, M.D. KEITH MATHENY, M.D. EWEN TSENG, M.D. KENNY CARTER, M.D.
WILLIAM B. COBB, M.D. KEITH MATHENY, M.D. EWEN TSENG, M.D. KENNY CARTER, M.D. INSTRUCTIONS FOR ALLERGY SKIN TESTING FOR SUBLINGUAL DROPS TREATMENT SKIN TESTING 1. Discontinue all antihistamines, oral or
More informationallergy Asia Pacific Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy Original Article Lisha Li and Kai Guan *
Asia Pacific allergy pissn 2233-8276 eissn 2233-8268 Original Article Asia Pac Allergy 216;6:168-173 Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy Lisha Li and
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Medical Policy Manual Medicine, Policy No. 121 Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Next Review: October 2018 Last Review: October 2017 Effective: December 1, 2017 IMPORTANT
More informationCurrent and Future Prospects for the Treatment of Food Allergy
Current and Future Prospects for the Treatment of Food Allergy Robert A. Wood, MD Professor of Pediatrics and International Health Director, Pediatric Allergy and Immunology Director, Pediatric Clinical
More informationAuthors should appear in this order for PubMed:
1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Sublingual Immunotherapy: A focused allergen immunotherapy practice parameter update Authors should appear
More informationAllergy Immunotherapy: A New Role for the Family Physician
Allergy Immunotherapy: A New Role for the Family Physician Stephen A. Brunton, MD, FAAFP Adjunct Clinical Professor Department of Clinical Pharmacy Practice Roseman University Salt Lake City, Utah Executive
More informationAccording to the 2009 National Health Interview Survey, 7.8% of
REVIEW Subcutaneous and sublingual immunotherapy for allergic rhinitis: What is the evidence? Sarah K. Wise, M.D., 1 and Rodney J. Schlosser, M.D. 2 ABSTRACT Background: Increasing interest in sublingual
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy R&D and Business Briefing New York, May 2014 ALK s equity story An emerging speciality pharma with a global growth strategy Jens Bager President and CEO Today s
More informationChoosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose
DOI 10.1186/s13601-015-0088-1 Clinical and Translational Allergy REVIEW Open Access Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose Pascal Demoly 1*,
More informationInsect allergy PHILLIP L. LIEBERMAN, MD
Insect allergy PHILLIP L. LIEBERMAN, MD Disclosure Consultant/Advisory Board: Genentech, Meda, Mylan, Teva Speaker: Genentech, Meda, Merck, Mylan, Teva Learning Objectives Upon completion of this session,
More informationALLERGY TESTING AND TREATMENT
Status Active Medical and Behavioral Health Policy Section: Laboratory Policy Number: VI-02 Effective Date: 03/26/2014 Blue Cross and Blue Shield of Minnesota medical policies do not imply that members
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Grastek) Reference Number: CP.PMN.84 Effective Date: 11.16.16 Last Review Date: 08.18 Line of Business: Commercial, HIM, Medicaid Revision Log See Important Reminder at the end of this
More informationAllergen Immunotherapy
1 Allergen Immunotherapy FINAL ENVIRONMENTAL SCAN REPORT September 2015 FINAL REPORT 2 Conflict of Interest Statement No study members report any affiliations or financial involvement (e.g., employment,
More informationWhy does the body develop allergies?
Allergies & Hay Fever Millions of Americans suffer from nasal allergies, commonly known as hay fever. Often fragrant flowers are blamed for the uncomfortable symptoms, yet they are rarely the cause; their
More informationOdactra (house dust mite allergen extract) NEW PRODUCT SLIDESHOW
Odactra (house dust mite allergen extract) NEW PRODUCT SLIDESHOW Introduction Brand name: Odactra Generic name: House dust mite allergen extract (Dermatophagoides farinae, Dermatophagoides pteronyssinus)
More informationLEARN ABOUT ANOTHER WAY TO TREAT YOUR ALLERGIES
LEARN ABOUT ANOTHER WAY TO TREAT YOUR ALLERGIES WHAT ARE ALLERGIES? It s probably not something that you think about, but every time you open your mouth or inhale, tiny particles from the environment that
More informationJohn Bostock. Novel Immunotherapy Modalities. Catharrus aestivus. University Hospital Zürich. Thomas M. Kündig Dermatology Zurich University Hospital
John Bostock University Hospital Zürich Novel Immunotherapy Modalities 1819 Catharrus aestivus Thomas M. Kündig Dermatology Zurich University Hospital Charles Blackley William Dunbar 1873 Catarrhus aestivus
More informationimmunotherapy to parietaria. A controlled field study
O R I G I N A L A R T I C L E Eur Ann Allergy Clin Immunol VOL 42, N 3, 115-119, 2010 A. Musarra 1, D. Bignardi 2, C. Troise 2, G. Passalacqua 3 Long-lasting effect of a monophosphoryl lipidadjuvanted
More information