College of Pharmacy Advanced Clinical Pharmacology Spring 2013 Semester. Antibiotics PCN. Danita 1 Dee Narciso Pharm D

Size: px
Start display at page:

Download "College of Pharmacy Advanced Clinical Pharmacology Spring 2013 Semester. Antibiotics PCN. Danita 1 Dee Narciso Pharm D"

Transcription

1 College of Pharmacy Advanced Clinical Pharmacology Spring 2013 Semester Antibiotics PCN Danita 1 Dee Narciso Pharm D

2 2 Objectives Recognize the signs and symptoms of infection Become familiar with antibiotics that are commonly used and recognize areas of potential practical conflicts Recognize antibiotics that have interactions with other medications or illnesses Learn how to monitor for and adjust for changes in drug levels due to interactions with antibiotics

3 3 Introduction Signs and symptoms of infection Fever WBC increases Normal = 4,000 10,000 cells/mm 3 Increases in lymphocytes ~ TB, viral, or fungal infections Increases in monocytes ~ TB or lymphoma Increases in eosinophills ~ Allergy Local signs Pain, swelling, redness, tenderness, purulent discharge

4 4 Fever (pyrexia) Normal º F ( ºC) Rectal - 1ºF or 0.6ºC higher Axillary - 1ºF or 0.6ºC lower Hyperpyrexia Hypothermia Other Causes Trauma Malignancy Infarctions Blood disorders Various drugs Immune disorders False positives False negatives

5 5 Drug induced fever Beta lactams Anticonvulsants Allopurinol (Zyloprim) Gout Hydralazine Blood pressure Nitrofurantoin (Macrobid) UTI Sulfonamides Phenothiazines Methyldopa Blood pressure in pregnancy

6 6 Drug induced fever Sulfonamides Sulfamethoxazole Diuretics Anticonvulsants Celecoxib (Celebrex) Sumatriptan (Imitrex) Phenothiazines Promethazine Chlorpromazine (Thorazine) Thioridazine (Mellaril) Prochlorperazine (Compazine) False positives, false negatives???

7 7 Terms Bactericidal Bacteriostatic Beta-lactam antibiotics Beta-lactamases (penicillinase) Penicillin binding proteins (PBPs) Peptidoglycan Transpeptidases

8 Penicillin 8

9 Penicillin a beta-lactam antibiotic 9

10 10 Penicillin (PCN) Bactericidal vs. bacteriostatic MOA Bind to PBPs, inhibit the reaction (transpeptidase reaction) that cross links the peptidoglycan chain on the bacterial cell wall, and activate autolytic enzymes Time dependent killing The bacteria s defense Penicillinase (beta-lactamases) Changes in PBPs

11 11 Penicillins Natural pcn Penicillin G Penicillin VK Mild to moderate infection without bacteremia of the skin and respiratory tract Gonorrhea IM Syphilis - IM Neurosyphilis IM/IV Pharyngitis URI

12 12 Penicillins Penicillinase resistant Oxacillin Dicloxacillin Nafcillin MSSA infections Erysipelas Skin abscess CNS infections PCN can penetrate inflamed meninges

13 13 Penicillins Aminopenicillins Amoxicillin Ampicillin May be used in combination with a beta-lactamase inhibitor Augmentin amoxicillin and clavulanic acid Unasyn ampicillin and sulbactam Sinus infection Dental prophylaxis ENT and genitourinary infection Hpylori UTI Meningitis

14 14 Penicillins Extended spectrum (Carboxypenicillins/ureidopenicillins) Ticarcillin Piperacillin Used in combination with a beta-lactamase inhibitor Zosyn piperacillin and tazobactam Timentin ticarcillin and clavulanic acid IV UTI, systemic infections, complicated abdominal infections, etc

15 15 PCN - Kinetics Absorption Oral depends on ph Small intestines Distribution Lungs, liver, kidneys, muscle, bone, placenta, and urine Metabolism Liver limited and converted to inactive metabolites Excretion Mostly (60%) unchanged in the urine monitor renal function Bile nafcillin and oxacillin

16 16 Adverse drug reactions GI disturbances Nausea, diarrhea, black hairy tongue (ampicillin), Dermatologic Rash and redness CNS Agitation, anxiety, seizure, confusion, and behavioral changes Pseudomembranous colitis extended spectrum and aminopcns Liver toxicity - oxacillin Be aware when a patient has recently started a penicillin

17 17 Drug-drug interactions Probenecid Increase PCN concentrations Methotrexate PCNs reduce tubular secretion Tetracycline May reduce the effectiveness of PCNs Chloramphenicol May reduce the effectiveness of PCNs Neomycin Decreases the absorption of some PCNs Hormonal contraception Effectiveness is reduced with the use of some PCNs Anticoagulants PCNs may increase the bleeding risk

18 18 Allergy Allergy is the most common ADR related to penicillins and can range from itching, fever, and rash to nephritis and anaphylaxis An allergic reaction may occur 1 2 weeks after an injection (serum sickness) Oral allergy may present as Tongue swelling Nausea, vomiting, or diarrhea

19 19 Resistance (Saving our big guns for big bugs) Identify the organism Empiric therapy in some cases

20 20 PCN and UTI Signs and symptoms General Lower UTI Painful urination, urgency, frequency, nocturia, blood in urine, and suprapubic heaviness Upper UTI Flank pain, fever, nausea, vomiting, and muscle weakness Elderly Altered mental status, change in eating habits, or GI symptoms Indwelling catheters and neurologic disorders Usually develop upper UTI with bacteremia due to the absence of symptoms

21 21 Questions??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

AXITAB-CV TAB. COMPOSITION :

AXITAB-CV TAB. COMPOSITION : AXITAB-CV TAB. COMPOSITION : Each film coated tablet contains: Cefuroxime Axetil I.P. Eq. to Anhydrous 500mg. Potassium Clavulanate Diluted I.P. Eq. to Clavulanic Acid 125mg DESCRIPTION : Cefuroxime Axetil

More information

PHARMACOLOGY II. Dr Shariq Syed Associate Professor AIKTC, SoP

PHARMACOLOGY II. Dr Shariq Syed Associate Professor AIKTC, SoP PHARMACOLOGY II Dr Shariq Syed Associate Professor AIKTC, SoP INTRODUCTION TO BACTERIA! INTRODUCTION TO BACTERIA! THEY COME IN DIFFERENT SHAPES ANTIMICROBIAL SITES OF ACTION SULPHONAMIDES 1930, Physician/researcher

More information

STRUCTURE OF COMMONLY USED PENICILLINS

STRUCTURE OF COMMONLY USED PENICILLINS PENICILLINS Alice Prince I. CHEMISTRY A basic structure of penicillins consists of a nucleus with three components: a thiazolidine ring, a β-lactam ring and a side chain. The side chain determines, in

More information

PACKAGE INSERT USP ANTIBIOTIC

PACKAGE INSERT USP ANTIBIOTIC Pr AMPICILLIN for Injection USP ANTIBIOTIC ACTIONS AND CLINICAL PHARMACOLOGY Ampicillin has a broad spectrum of bactericidal activity against many gram-positive and gramnegative aerobic and anaerobic bacteria.

More information

EMPIRICAL TREATMENT OF SELECT INFECTIONS ADULT GUIDELINES. Refer to VIHA Algorithm for the empiric treatment of Urinary Tract Infection

EMPIRICAL TREATMENT OF SELECT INFECTIONS ADULT GUIDELINES. Refer to VIHA Algorithm for the empiric treatment of Urinary Tract Infection URINARY TRACT Refer to VIHA Algorithm for the empiric treatment of Urinary Tract Infection and Asymptomatic Bacteriuria on the VIHA Intranet: https://intranet.viha.ca/departments/pharmacy/clinical_pharmacy/pages/infec

More information

RESISTANCE TO ANTIBIOTICS. A. Some scary statistics. B. Nature of genotypic alterations drug resistance

RESISTANCE TO ANTIBIOTICS. A. Some scary statistics. B. Nature of genotypic alterations drug resistance IV. RESISTANCE T ANTIBITICS A. Some scary statistics B. Nature of genotypic alterations drug resistance 1. Spontaneous mutations a) is the origin of resistance b) occurs in low frequency 1/10 6-1/10 8

More information

Summary of Product Characteristics

Summary of Product Characteristics 1 NAME OF THE MEDICINAL PRODUCT Calvepen 666 mg Tablets. Summary of Product Characteristics 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 666 mg of Phenoxymethylpenicillin Calcium equivalent

More information

Amoxitid 125 Suspension Each teaspoonful (5 ml) contains Amoxicillin (as trihydrate) 125 mg.

Amoxitid 125 Suspension Each teaspoonful (5 ml) contains Amoxicillin (as trihydrate) 125 mg. AMOXITID Composition Amoxitid 250 Capsules Each capsule contains Amoxicillin (as trihydrate) 250 mg. Capsules & Suspension Amoxitid 500 Capsules Each capsule contains Amoxicillin (as trihydrate) 500 mg.

More information

PRESCRIBING INFORMATION APO-PEN-VK

PRESCRIBING INFORMATION APO-PEN-VK PRESCRIBING INFORMATION APO-PEN-VK Penicillin V Potassium (Potassium Phenoxymethyl Penicillin) Tablets USP 500,000 i.u. (300 mg) Antibiotic Powder for suspension USP 500,000 i.u./5 Ml (300 mg/5 ml) Powder

More information

Urinary Tract Infections: From Simple to Complex. Adriane N Irwin, MS, PharmD, BCACP Clinical Assistant Professor Ambulatory Care October 25, 2014

Urinary Tract Infections: From Simple to Complex. Adriane N Irwin, MS, PharmD, BCACP Clinical Assistant Professor Ambulatory Care October 25, 2014 Urinary Tract Infections: From Simple to Complex Adriane N Irwin, MS, PharmD, BCACP Clinical Assistant Professor Ambulatory Care October 25, 2014 Learning Objectives Develop empiric antimicrobial treatment

More information

Diagnosis and Management of UTI s in Care Home Settings. To Dip or Not to Dip?

Diagnosis and Management of UTI s in Care Home Settings. To Dip or Not to Dip? Diagnosis and Management of UTI s in Care Home Settings To Dip or Not to Dip? 1 Key Summary Points: Treat the patient NOT the urine In people 65 years, asymptomatic bacteriuria is common. Treating does

More information

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

2 QUALITATIVE AND QUANTITATIVE COMPOSITION SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT Phenoxymethylpenicillin Sugar Free 250mg / 5ml Powder for Oral Solution 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each 5ml contains 277.2mg

More information

Development of C sporins. Beta-lactam antibiotics - Cephalosporins. Second generation C sporins. Targets - PBP s

Development of C sporins. Beta-lactam antibiotics - Cephalosporins. Second generation C sporins. Targets - PBP s Beta-lactam antibiotics - Cephalosporins Development of C sporins Targets - PBP s Activity - Cidal - growing organisms (like the penicillins) Principles of action - Affinity for PBP s Permeability properties

More information

PATIENT INFORMATION LEAFLET

PATIENT INFORMATION LEAFLET PATIENT INFORMATION LEAFLET Oramox (Amoxicillin Oral Suspension BP) 125mg/5ml Oramox (Amoxicillin Oral Suspension BP) 250mg/5ml Amoxicillin (as amoxicillin trihydrate) Read all of this leaflet carefully

More information

PACKAGE LEAFLET: INFORMATION FOR THE PATIENT

PACKAGE LEAFLET: INFORMATION FOR THE PATIENT PACKAGE LEAFLET: INFORMATION FOR THE PATIENT Kopen Sugar Free 125mg/5ml and 250mg/5ml Powder for Oral Solution Phenoxymethylpenicillin Read all of this leaflet carefully before you start taking this medicine

More information

MICHIGAN MEDICINE GUIDELINES FOR TREATMENT OF URINARY TRACT INFECTIONS IN ADULTS

MICHIGAN MEDICINE GUIDELINES FOR TREATMENT OF URINARY TRACT INFECTIONS IN ADULTS When to Order a Urine Culture: Asymptomatic bacteriuria is often treated unnecessarily, and accounts for a substantial burden of unnecessary antimicrobial use. National guidelines recommend against testing

More information

Urinary tract infection. Mohamed Ahmed Fouad Lecturer of pediatrics Jazan faculty of medicine

Urinary tract infection. Mohamed Ahmed Fouad Lecturer of pediatrics Jazan faculty of medicine Urinary tract infection Mohamed Ahmed Fouad Lecturer of pediatrics Jazan faculty of medicine Objectives To differentiate between types of urinary tract infections To recognize the epidemiology of UTI in

More information

SUMMARY OF PRODUCT CHARACTERISTICS

SUMMARY OF PRODUCT CHARACTERISTICS SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT Phenoxymethylpenicillin 250mg/5ml Oral Solution Sugar Free BP 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each 5ml of Oral Solution contains

More information

Other β-lactam. A. Carbapenems:

Other β-lactam. A. Carbapenems: A. Carbapenems: Other β-lactam Carbapenems are synthetic β-lactam antibiotics Differ in structure from the penicillins in that the sulfur atom of the thiazolidine ring. Imipenem, meropenem, doripenem,

More information

VI.2 Elements for a public summary. VI.2.1 Overview of disease epidemiology

VI.2 Elements for a public summary. VI.2.1 Overview of disease epidemiology VI.2 Elements for a public summary VI.2.1 Overview of disease epidemiology Sinus infection (Acute bacterial sinusitis) Sinus infection (upper respiratory infection) is short-lived infection of the sinuses,

More information

ZINEX. Composition Each tablet contains Cefuroxime (as axetil) 250 or 500 mg

ZINEX. Composition Each tablet contains Cefuroxime (as axetil) 250 or 500 mg ZINEX Composition Each tablet contains Cefuroxime (as axetil) 250 or 500 mg Tablets Action Cefuroxime axetil owes its bactericidal activity to the parent compound cefuroxime. Cefuroxime is a well-characterized

More information

2019 PHP PRIMARY CARE INCENTIVE

2019 PHP PRIMARY CARE INCENTIVE Primary Care Physicians (PCP) of Physicians Health Network (PHN) may be eligible for an incentive payment in accordance with this PHP PCP Incentive (hereinafter referred to as the PCP Incentive ). As described

More information

gram neg.(semisynthetic) Bacteria Drugs that inhibit cell wall synthesis Drug Action Organisms Comments Spectrum of Action Mycobacterium

gram neg.(semisynthetic) Bacteria Drugs that inhibit cell wall synthesis Drug Action Organisms Comments Spectrum of Action Mycobacterium Mickey Dufilho s Drugs and Bugs Revised 10/10/15 Bacteria Drugs that Inhibit Cell Wall Synthesis Drug Action Spectrum of Action Comments Spectrum of Action Bacitracin Beta-Lactam antibiotics Penicillin

More information

Package leaflet: Information for the user. Piperacillin/Tazobactam Actavis 4 g / 0.5 g powder for solution for infusion. piperacillin / tazobactam

Package leaflet: Information for the user. Piperacillin/Tazobactam Actavis 4 g / 0.5 g powder for solution for infusion. piperacillin / tazobactam Package leaflet: Information for the user Piperacillin/Tazobactam Actavis 2 g / 0.25 g powder for solution for infusion Piperacillin/Tazobactam Actavis 4 g / 0.5 g powder for solution for infusion piperacillin

More information

PATIENT INFORMATION LEAFLET. Oramox 250mg Hard Capsules Oramox 500mg Hard Capsules Amoxicillin (as amoxicillin trihydrate)

PATIENT INFORMATION LEAFLET. Oramox 250mg Hard Capsules Oramox 500mg Hard Capsules Amoxicillin (as amoxicillin trihydrate) PATIENT INFORMATION LEAFLET Oramox 250mg Hard Capsules Oramox 500mg Hard Capsules Amoxicillin (as amoxicillin trihydrate) Read all of this leaflet carefully before you start taking this medicine because

More information

Annex I: Proposed Core Safety Profile (CSP) 4.3 Contraindications

Annex I: Proposed Core Safety Profile (CSP) 4.3 Contraindications Annex I: Proposed Core Safety Profile (CSP) 4.3 Contraindications Hypersensitivity to cefuroxime or to any of the excipients listed in section 6.1. Patients with known hypersensitivity to cephalosporin

More information

Salicylates: Interactions 10/14/2009. Salicylates DRUGS USED IN THE MANAGEMENT OF MUSCULOSKELETAL DISORDERS. Chapters 17, 18, 34 & Pages 577 &

Salicylates: Interactions 10/14/2009. Salicylates DRUGS USED IN THE MANAGEMENT OF MUSCULOSKELETAL DISORDERS. Chapters 17, 18, 34 & Pages 577 & DRUGS USED IN THE MANAGEMENT OF MUSCULOSKELETAL DISORDERS Chapters 17, 18, 34 & Pages 577 & 579-586 Salicylates aspirin Have analgesic, antipyretic, and anti-inflammatory effects. Inhibits the production

More information

Lower Urinary Tract Infection (UTI) in Males

Lower Urinary Tract Infection (UTI) in Males Lower Urinary Tract Infection (UTI) in Males Clinical presentation For patients in care homes see UTI in adults where IV Antibiotics in the community may be appropriate (under development) History and

More information

Antibiotics: Definition CHAPTER 37. Antibiotics. NDEG 26 A Pharmacology I Eliza Rivera-Mitu, RN, MSN. Antibiotics: Classes

Antibiotics: Definition CHAPTER 37. Antibiotics. NDEG 26 A Pharmacology I Eliza Rivera-Mitu, RN, MSN. Antibiotics: Classes CHAPTER 37 Antibiotics NDEG 26 A Pharmacology I Eliza Rivera-Mitu, RN, MSN Antibiotics: Definition Medications used to treat bacterial infections Ideally, before beginning antibiotic therapy, the suspected

More information

URINARY TRACT INFECTIONS

URINARY TRACT INFECTIONS URINARY TRACT INFECTIONS Learning Objectives Identify signs and symptoms that may indicate presence of UTI (both complicated and uncomplicated) List common causative organisms and risk factors for UTIs

More information

AMPICLOX TM Ampicillin-cloxacillin

AMPICLOX TM Ampicillin-cloxacillin AMPICLOX TM Ampicillin-cloxacillin QUALITATIVE AND QUANTITATIVE COMPOSITION AMPICLOX 500mg Capsules: Each capsule contains 250 mg ampicillin as Ampicillin Trihydrate and 250 mg cloxacillin as Cloxacillin

More information

Diabetes Oral Agents Pharmacology. University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D

Diabetes Oral Agents Pharmacology. University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D Diabetes Oral Agents Pharmacology University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D 1 Learning Objectives Understand the role of the utilization of free

More information

SUMMARY OF PRODUCT CHARACTERISTICS

SUMMARY OF PRODUCT CHARACTERISTICS SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT Phenoxymethylpenicillin 125 mg/5ml Oral Solution or Tenkicin 125 mg/5ml Oral Solution 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each

More information

GASTROENTEROLOGY PATIENT QUESTIONNAIRE - PLEASE PRINT

GASTROENTEROLOGY PATIENT QUESTIONNAIRE - PLEASE PRINT GASTROENTEROLOGY PATIENT QUESTIONNAIRE - PLEASE PRINT Full name: Date: Telephone Number: Age: Address: Email address: CHIEF COMPLAINTS(List the problems about which you came to see the doctor) 1) 2) 3)

More information

Ameba has two stages of development: cyst and trophozoite

Ameba has two stages of development: cyst and trophozoite Amebiasis A parasitic disease of worldwide public health importance Second to malaria in mortality due to protozoan parasites Invasive amebiasis results in up to 100,000 deaths / year Amebiasis is infection

More information

AUGMENTIN is also used to prevent infection from major surgery.

AUGMENTIN is also used to prevent infection from major surgery. Injection Potassium clavulanate/amoxicillin sodium equivalent to 100 mg clavulanic acid/500 mg amoxicillin Potassium clavulanate/amoxicillin sodium equivalent to 200 mg clavulanic acid/1 g amoxicillin

More information

Appropriate Use of Antibiotics for the Treatment of Acute Upper Respiratory Tract Infections in Adults

Appropriate Use of Antibiotics for the Treatment of Acute Upper Respiratory Tract Infections in Adults Appropriate Use of Antibiotics for the Treatment of Acute Upper Respiratory Tract Infections in Adults Kyong Ran Peck, M.D. Division of Infectious Diseases Sungkyunkwan University School of Medicine, Samsung

More information

Patient Interview Form

Patient Interview Form Page 1 of 5 Orange Coast Memorial Office: 18111 Brookhurst Ave. Suite 5200, Fountain Valley, CA 92708 * Tel: (714) 962-7705 * Fax: (714) 861-4552 www.unitedgi.com Patient Interview Form Patient Information

More information

Phenoxymethylpenicillin-AFT AFT Pharmaceuticals Pty. Ltd

Phenoxymethylpenicillin-AFT AFT Pharmaceuticals Pty. Ltd Phenoxymethylpenicillin-AFT AFT Pharmaceuticals Pty. Ltd Name of the medicine Phenoxymethylpenicillin-AFT, powder for oral liquid, contains phenoxymethylpenicillin as the potassium salt. Phenoxymethylpenicillin

More information

Choosing an appropriate antimicrobial agent. 3) the spectrum of potential pathogens

Choosing an appropriate antimicrobial agent. 3) the spectrum of potential pathogens Choosing an appropriate antimicrobial agent Consider: 1) the host 2) the site of infection 3) the spectrum of potential pathogens 4) the likelihood that these pathogens are resistant to antimicrobial agents

More information

Summary of Product Characteristics

Summary of Product Characteristics 1 NAME OF THE MEDICINAL PRODUCT Oramox (Amoxicillin Oral Suspension BP) 125mg / 5ml Summary of Product Characteristics 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each 5ml of reconstituted suspension contains

More information

Health Questionnaire

Health Questionnaire Patient Name Date of Birth Thank you for choosing Southern Cancer Center for your care. To help us best prepare for your appointment, please complete this form and bring it to your appointment. If you

More information

NEW ZEALAND DATA SHEET 2. QUALITATIVE AND QUANTITATIVE COMPOSITION

NEW ZEALAND DATA SHEET 2. QUALITATIVE AND QUANTITATIVE COMPOSITION NEW ZEALAND DATA SHEET 1. PHENOXYMETHYLPENICILLIN AFT Phenoxymethylpenicillin-AFT (granules for oral solution, 125 mg/5 ml and 250 mg/ 5 ml) 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Phenoxymethylpenicillin-AFT

More information

Functional Blood Chemistry & CBC Analysis

Functional Blood Chemistry & CBC Analysis Functional Blood Chemistry & CBC Analysis Session 11 Immune Markers Immune Dysfunctions Immune Deficiency, Allergies, Immune Over Activity Causes of Immune Dysregulation External Influences Pharmaceutical

More information

FEVER. What is fever?

FEVER. What is fever? FEVER What is fever? Fever is defined as a rectal temperature 38 C (100.4 F), and a value >40 C (104 F) is called hyperpyrexia. Body temperature fluctuates in a defined normal range (36.6-37.9 C [97.9-100.2

More information

SUMMARY OF PRODUCT CHARACTERISTICS. Each tablet contains phenoxymethylpenicillin 250 mg (as phenoxymethylpenicillin potassium).

SUMMARY OF PRODUCT CHARACTERISTICS. Each tablet contains phenoxymethylpenicillin 250 mg (as phenoxymethylpenicillin potassium). SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT Phenoxymethylpenicillin, 250mg, Film-coated Tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains phenoxymethylpenicillin

More information

Introduction to. Pharmacokinetics. University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D

Introduction to. Pharmacokinetics. University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D Introduction to 1 Pharmacokinetics University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D 2 Learning objectives Understand compartment models and how they effects

More information

SUMMARY OF PRODUCT CHARACTERISTICS

SUMMARY OF PRODUCT CHARACTERISTICS SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT Oramox 250mg Hard Capsules 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains Amoxicillin Trihydrate equivalent to 250mg

More information

Index. urologic.theclinics.com. Note: Page numbers of article titles are in boldface type.

Index. urologic.theclinics.com. Note: Page numbers of article titles are in boldface type. Index Note: Page numbers of article titles are in boldface type. A Acinetobacter baumannii, carbapenem-resistant, 497 498 Adolescents, urinary tract infections in, 520 521 Aminoglycosides, for UTIs and

More information

Beta lactam Allergies Facts vs. Fears

Beta lactam Allergies Facts vs. Fears 1 Beta lactam Allergies Facts vs. Fears Meghan Jeffres, PharmD Assistant Professor, Department of Clinical Pharmacy University of Colorado Skaggs School of Pharmacy Statement of Disclosures 2 No financial

More information

Patient Interview Form

Patient Interview Form Page 1 of 6 Patient Interview Form Patient Information First Name: MRN: Age: Last Name: Date Of Birth: Notes: Email Please check one as your preferred email for communications Personal: Work: Race Select

More information

Infection Prevention and Control in Long Term Care Part 2

Infection Prevention and Control in Long Term Care Part 2 Infection Prevention and Control in Long Term Care Part 2 Course ID: 1029 - Credit Hours: 2 Author(s) Bonnie Chustz,RN, BSN WCC Disclosures None Accreditation KLA Education Services LLC is accredited by

More information

NEW PATIENT HEALTH HISTORY

NEW PATIENT HEALTH HISTORY NEW PATIENT HEALTH HISTORY Patient Name Today s Date Age Birth Date Date of last physical examination What is your reason for initial visit? Pharmacy Name & Telephone # NOTE: If you have prior records

More information

Capital Health Medical Center - Hopewell NEUROSURGICAL-ONCOLOGY Patient History

Capital Health Medical Center - Hopewell NEUROSURGICAL-ONCOLOGY Patient History Capital Health Medical Center - Hopewell NEUROSURGICAL-ONCOLOGY Patient History Please take a few minutes and complete the following questions before you see the doctors so that we may learn a bit more

More information

For the Patient: Methotrexate Other names: MTX

For the Patient: Methotrexate Other names: MTX For the Patient: Methotrexate Other names: MTX Methotrexate (meth oh trex ate) is a drug that is used to treat many types of cancers. It is a clear yellow liquid that is injected into a vein. Tell your

More information

Digestion: Small and Large Intestines Pathology

Digestion: Small and Large Intestines Pathology Digestion: Small and Large Intestines Pathology Dr. Ritamarie Loscalzo Medical Disclaimer: The information in this presentation is not intended to replace a one onone relationship with a qualified health

More information

Urinary Tract Infections

Urinary Tract Infections Urinary Tract Infections Michelle Eslami, M.D., FACP Professor of Medicine Division of Geriatrics David Geffen SOM at UCLA Urinary Tract Infection (UTI) One of most common infections in outpatient and

More information

Anxiety Pharmacology UNIVERSITY OF HAWAI I HILO PRE -NURSING PROGRAM

Anxiety Pharmacology UNIVERSITY OF HAWAI I HILO PRE -NURSING PROGRAM Anxiety Pharmacology UNIVERSITY OF HAWAI I HILO PRE NURSING PROGRAM NURS 203 GENERAL PHARMACOLOGY DANITA NARCISO PHARM D Learning Objectives Understand the normal processing of fear vs fear processing

More information

Slide 1. Slide 2. Slide 3. Drug Action and Handling. Lesson 2.1. Lesson 2.1. Drug Action and Handling. Drug Action and Handling.

Slide 1. Slide 2. Slide 3. Drug Action and Handling. Lesson 2.1. Lesson 2.1. Drug Action and Handling. Drug Action and Handling. Slide 1 Drug Action and Handling Chapter 2 1 Slide 2 Lesson 2.1 Drug Action and Handling 1. Differentiate dose, potency, and efficacy in the context of the actions of drugs. 2. Explain the pharmacologic

More information

If you have any concerns about being given this medicine, ask your doctor or pharmacist.

If you have any concerns about being given this medicine, ask your doctor or pharmacist. PRIMAXIN imipenem/cilastatin sodium 500 mg/500 mg Vial for injection What is in this leaflet This leaflet answers some common questions about PRIMAXIN. It does not contain all the available information.

More information

PRIMAXIN Imipenem/Cilastatin sodium

PRIMAXIN Imipenem/Cilastatin sodium PRIMAXIN Imipenem/Cilastatin sodium Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about PRIMAXIN. It does not contain all the available information. It

More information

URINARY TRACT INFECTIONS IN LONG TERM CARE. Tuesday, 8 November, 11

URINARY TRACT INFECTIONS IN LONG TERM CARE. Tuesday, 8 November, 11 URINARY TRACT INFECTIONS IN LONG TERM CARE OBJECTIVES UNDERSTAND THE SCALE OF DISEASE IN LTC SETTINGS DEVELOP AN UNDERSTANDING OF THE DIFFERENT PRESENTATIONS OF UTIs IN THIS SETTING AND WORKUP BECOME AWARE

More information

PATIENT INFORMATION LEAFLET TREGS

PATIENT INFORMATION LEAFLET TREGS PATIENT INFORMATION LEAFLET TREGS 1 g IM powder for injection For intramuscular use. Active ingredient: Each vial contains: 1000 mg ceftriaxone as 1192.89 mg ceftriaxone sodium. Each ampoule contains:

More information

Elements for a Public Summary. Overview of disease epidemiology

Elements for a Public Summary. Overview of disease epidemiology VI.2 VI.2.1 Elements for a Public Summary Overview of disease epidemiology Pneumococcal infection is a major cause of morbidity mortality worldwide. In 2005, WHO estimated that 1.6 million deaths were

More information

Surveillance Definitions of Infections in Long-Term Care Facilities

Surveillance Definitions of Infections in Long-Term Care Facilities Surveillance Definitions of Infections in Long-Term Care Facilities Revisiting the McGeer Criteria guidelines for defining infections were made available in September, 2012. Many of the different categories

More information

Annex 4. Case definitions of infections

Annex 4. Case definitions of infections Protocol for validation of PPS of HAIs and antimicrobial use in European LTCF TECHNICAL DOCUMENT Annex 4. Case definitions of infections Healthcare-associated infections and antimicrobial use in European

More information

AMOXYCILLIN SANDOZ Amoxycillin Trihydrate capsules and suspension

AMOXYCILLIN SANDOZ Amoxycillin Trihydrate capsules and suspension Amoxycillin Trihydrate capsules and suspension Consumer Medicine Information WHAT IS IN THIS LEAFLET This leaflet answers some common questions about It does not contain all the available information.

More information

Management of suspected bacterial urinary tract infections in older people. based on SIGN 88. Jane Lawson Infection Prevention and Control Nurse

Management of suspected bacterial urinary tract infections in older people. based on SIGN 88. Jane Lawson Infection Prevention and Control Nurse Management of suspected bacterial urinary tract infections in older people based on SIGN 88 Jane Lawson Infection Prevention and Control Nurse Bacterial urinary tract infection (UTI s) UTI s are common

More information

Treatment Regimens for Bacterial Urinary Tract Infections. Characteristic Pathogen. E. coli, S.saprophyticus P.mirabilis, K.

Treatment Regimens for Bacterial Urinary Tract Infections. Characteristic Pathogen. E. coli, S.saprophyticus P.mirabilis, K. HEALTHSPAN URINARY TRACT INFECTIONS (ADULT FEMALE) Methodology: Evidence-Based Issue Date: 1-98 Champion: Internal Medicine Most Recent Review: 4-10, 4-12, 4-14 Key Stakeholders: IM, Urology, Next Review:

More information

DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES

DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DISCLAIMER: This Clinical Practice Guideline (CPG) generally describes a recommended course of treatment for patients with the identified health

More information

Prescription Pain Management. University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita 1 Narciso Pharm D

Prescription Pain Management. University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita 1 Narciso Pharm D Prescription Pain Management University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita 1 Narciso Pharm D 2 Objectives Understand how to preform a pain assessment Know which medications

More information

4/14/2010. Theoretical purpose of fever? Andrea Marmor, MD, MSEd Assistant Clinical Professor, Pediatrics UCSF April 13, 2010

4/14/2010. Theoretical purpose of fever? Andrea Marmor, MD, MSEd Assistant Clinical Professor, Pediatrics UCSF April 13, 2010 Andrea Marmor, MD, MSEd Assistant Clinical Professor, Pediatrics UCSF April 13, 2010 Parental touch? Absence of fever more reliable than presence. Axillary and tympanic Vulnerable to environmental and

More information

Please list all medications you are currently taking (include aspirin, vitamins, hormones), Dosage, and Frequency.

Please list all medications you are currently taking (include aspirin, vitamins, hormones), Dosage, and Frequency. GENERAL SURGICAL ASSOCIATES A practice of Lehigh Valley Physician Group Suite 208 ~ 1240 S. Cedar Crest Boulevard ~ Allentown, PA 18103 Phone: (610) 402-9780 PLEASE COMPLETE THIS FORM PRIOR TO YOUR VISIST

More information

Penicillin VK Official FDA information, side effects and uses.

Penicillin VK Official FDA information, side effects and uses. Page 1 of 10 A to Z Drug List Drugs by Condition Drugs by Class Side Effects Dosage Pregnancy New Drugs Pipeline Images Professional Information Consumer FDA > Penicillin VK Relat Penicillin VK Generic

More information

Northeast Ohio Urogynecology Patient History Intake Form. Last Name First Name Age. Date of Birth Race Referring Physician.

Northeast Ohio Urogynecology Patient History Intake Form. Last Name First Name Age. Date of Birth Race Referring Physician. Northeast Ohio Urogynecology Patient History Intake Form Last Name _First Name Age_ Date of Birth Race Referring Physician Reason for Visit: _ Allergies: Preferred Lab (circle): QUEST LABCARE PLUS LABCORP

More information

PACKAGE LEAFLET: Information for the patient. SULFAMETOPRIM Tablets - (400 mg / 80 mg) (Sulfamethoxazole / Trimethoprim)

PACKAGE LEAFLET: Information for the patient. SULFAMETOPRIM Tablets - (400 mg / 80 mg) (Sulfamethoxazole / Trimethoprim) PACKAGE LEAFLET: Information for the patient SULFAMETOPRIM Tablets - (400 mg / 80 mg) (Sulfamethoxazole / Trimethoprim) Read this leaflet carefully before you start taking this medicine. Keep this leaflet.

More information

Penicillin Allergy and Use of Other Antibiotics

Penicillin Allergy and Use of Other Antibiotics Penicillin Allergy and Use of Other Antibiotics 7300-646PT Policy No.: 7310-646PT 8790-646PT Original Policy Date: 10/10/2016 Revision Date(s): Review Date(s): Approval: 11/17/16 Pharmacy & Therapeutics

More information

Bend Surgical Associates. Michael J. Mastrangelo, MD, FACS. Medication Name Dosage Frequency Medication Name Dosage Frequency

Bend Surgical Associates. Michael J. Mastrangelo, MD, FACS. Medication Name Dosage Frequency Medication Name Dosage Frequency Bend Surgical Associates Michael J. Mastrangelo, MD, FACS PATIENT NAME: DATE F BIRTH: MEDICATINS Please list all of your current prescription, non-prescription medications, vitamins, minerals, and supplements.

More information

Beta-lactamase production should have no effect on Azithromycin activity.

Beta-lactamase production should have no effect on Azithromycin activity. AZIMEX Composition Azimex 250 Capsules Each capsule contains Azithromycin (as dihydrate) 250 mg Capsules Azimex 500 mg Capsules Each capsule contains Azithromycin (as dihydrate) 500 mg Action Azithromycin

More information

The McMaster at night Pediatric Curriculum

The McMaster at night Pediatric Curriculum The McMaster at night Pediatric Curriculum Robinson, J, et al. and the Canadian Pediatric Society. Urinary tract infection in infants and children: Diagnosis and management. Pediatr Child Health 2014;

More information

DNA CENTER New Patient Information

DNA CENTER New Patient Information DNA CENTER New Patient Information Name Email: Address City State Zip Home Phone Work Cell Phone Social Security Number Date of birth Gender ( Male/Female) Age Please Circle: Hispanic/Latin or Non Hispanic/Latin

More information

Diagnosis and Treatment of Respiratory Illness in Children and Adults

Diagnosis and Treatment of Respiratory Illness in Children and Adults Page 1 of 9 Main Algorithm Annotations 1. Patient Reports Some Combination of Symptoms Patients may present for an appointment, call into a provider to schedule an appointment or nurse line presenting

More information

KAISER PERMANENTE OHIO URINARY TRACT INFECTIONS (ADULT FEMALE)

KAISER PERMANENTE OHIO URINARY TRACT INFECTIONS (ADULT FEMALE) KAISER PERMANENTE OHIO URINARY TRACT INFECTIONS (ADULT FEMALE) Methodology: Evidence-Based Issue Date: 1-98 Champion: Internal Medicine Most Recent Review: 4-10, 4-12 Key Stakeholders: IM, Urology, Next

More information

Package leaflet: Information for the user. Cefixime ABR 100 mg/5 ml powder for oral suspension Cefixime

Package leaflet: Information for the user. Cefixime ABR 100 mg/5 ml powder for oral suspension Cefixime Package leaflet: Information for the user Cefixime ABR 100 mg/5 ml powder for oral suspension Cefixime Read all of this leaflet carefully before you start taking this medicine because it contains important

More information

Table 1 CDC Diagnostic Criteria for Chronic Fatigue Syndrome

Table 1 CDC Diagnostic Criteria for Chronic Fatigue Syndrome Table 1 CDC Diagnostic Criteria for Chronic Fatigue Syndrome Major Criteria New onset of fatigue causing 50% reduction in activity for at least 6 months. Exclusion of other illnesses that can cause fatigue.

More information

AMCLAVOX DUO 500/125 & AMCLAVOX DUO FORTE 875/125 TABLETS. You may need to read it again. DUO & AMCLAVOX DUO FORTE tablets used for?

AMCLAVOX DUO 500/125 & AMCLAVOX DUO FORTE 875/125 TABLETS. You may need to read it again. DUO & AMCLAVOX DUO FORTE tablets used for? 500/125 & FORTE 875/125 TABLETS Amoxicillin and clavulanic acid CONSUMER MEDICINE INFORMATION What is in this leaflet? Please read this leaflet carefully before you take & This leaflet answers some common

More information

DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES

DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DISCLAIMER: This Clinical Practice Guideline (CPG) generally describes a recommended course of treatment for patients with the identified health

More information

AUSTRAPEN ampicillin (as sodium)

AUSTRAPEN ampicillin (as sodium) AUSTRAPEN ampicillin (as sodium) Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about AUSTRAPEN. It does not contain all the available information. It

More information

Bicillin L-A Benzathine benzylpenicillin tetrahydrate

Bicillin L-A Benzathine benzylpenicillin tetrahydrate Bicillin L-A Benzathine benzylpenicillin tetrahydrate Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about Bicillin L- A. It does not contain all the available

More information

PENICILLIN V POTASSIUM - penicillin v potassium tablet, film coated Aurobindo Pharma Limited

PENICILLIN V POTASSIUM - penicillin v potassium tablet, film coated Aurobindo Pharma Limited PENICILLIN V POTASSIUM - penicillin v potassium tablet, film coated To reduce the development of drug-resistant bacteria and maintain the effectiveness of penicillin V potassium and other antibacterial

More information

JUST FOR KIDS SELECTED IMPORTANT SAFETY INFORMATION

JUST FOR KIDS SELECTED IMPORTANT SAFETY INFORMATION JUST FOR KIDS For children ages 6-17 with moderately to severely active Crohn s disease or ulcerative colitis (UC) who haven t responded well to other therapies SELECTED IMPORTANT SAFETY INFORMATION REMICADE

More information

IMIPENEM+CILASTATIN RBX

IMIPENEM+CILASTATIN RBX IMIPENEM+CILASTATIN RBX imipenem/cilastatin sodium 500 mg/500 mg Powder for Solution for Infusion What is in this leaflet This leaflet answers some common questions about IMIPENEM+CILASTATIN RBX. It does

More information

+ Color Change - + Hearing Loss - + Apnea - + Enuresis (urine - + Tremors - + Rash -

+ Color Change - + Hearing Loss - + Apnea - + Enuresis (urine - + Tremors - + Rash - Review of Systems: 0-1 year old Constitution neg Eyes neg GI neg Neurological neg + Activity Change - + Eye Discharge - + Reflux - + Facial Asymmetry - + Appetite Change - + Eye Redness - + Vomiting -

More information

Sound View Acupuncture and Chinese Herbs 5410 California Ave SW, #202, Seattle, WA

Sound View Acupuncture and Chinese Herbs 5410 California Ave SW, #202, Seattle, WA Sound View Acupuncture and Chinese Herbs 5410 California Ave SW, #202, Seattle, WA 98136 206.200.3595 Today s date Name Legal name (if different) Phone (primary) (secondary) Address City State Zip Email

More information

ROSOBAC-1GM / ROSOBAC-FORT

ROSOBAC-1GM / ROSOBAC-FORT ROSOBAC-1GM / ROSOBAC-FORT ROSOBAC - 1GM. COMPOSITION : Each vial contains Sterile Cefoperazone Sodium IP Eq. to Anhydrous Cefoperazone - Sterile Sulbactam Sodium USP Eq. to Anhydrous Sulbactam - ROSOBAC

More information

CAN AZITHROMYCIN TABLETS BE CUT IN HALF

CAN AZITHROMYCIN TABLETS BE CUT IN HALF CAN AZITHROMYCIN TABLETS BE CUT IN HALF Can Azithromycin Tablets Be Cut In Half Azithromycin 500 mg liquid flavors list pdf Azithromycin for dog ear infection Azithromycin 250 mg safe during pregnancy

More information

Severe β-lactam allergy. Alternative (use for mild-moderate β-lactam allergy) therapy

Severe β-lactam allergy. Alternative (use for mild-moderate β-lactam allergy) therapy Recommended Empirical Antibiotic Regimens for MICU Patients Notes: The antibiotic regimens shown are general guidelines and should not replace clinical judgment. Always assess for antibiotic allergies.

More information

UTI are the most common genitourinary disease of childhood. The prevalence of UTI at all ages is girls and 1% of boys.

UTI are the most common genitourinary disease of childhood. The prevalence of UTI at all ages is girls and 1% of boys. UTI are the most common genitourinary disease of childhood. The prevalence of UTI at all ages is girls and 1% of boys. 1-3% of Below 1 yr. male: female ratio is 4:1 especially among uncircumcised males,

More information

Fever in Children. Topics. Fever: Temperature over. Definiton Taking the temp Function of fever Reasons for treating fever How antipyretics work

Fever in Children. Topics. Fever: Temperature over. Definiton Taking the temp Function of fever Reasons for treating fever How antipyretics work Fever in Children Sue Moore RN, MSN, CCRN, CFRN, NP-C Topics Definiton Taking the temp Function of fever Reasons for treating fever How antipyretics work Fever: Temperature over 1 Taking the Temp Which

More information