Nutrition and Prolotherapy. Arden Andersen Ph.D., D.O, M.S.P.H. Family and Occupational Medicine

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1 Nutrition and Prolotherapy Arden Andersen Ph.D., D.O, M.S.P.H. Family and Occupational Medicine

2 Nutrition is fundamental to all life Prolotherapy is only as successful as putting together all the variables in favor of patient success Starts with appropriate diagnosis, followed by patient preparation, doctor training, tools/materials and timing.

3 The medical profession has historically disparaged nutrition as a component in health or restoring health, while at the same time contending itself to champion science, e.g. biochemistry, cell biology, endocrinology

4 We have learned well how to manipulate human chemistry and physiology w/o good understanding of the cellular chemistry involved that every drug adversely affects cells, tissues and organs ultimately by way of chelating, disrupting, oxidizing or displacing nutrient minerals and vitamins.

5 We are eager to learn how drugs manipulate body chemistry to alter physiology and behavior in reductionistic, linear perspectives, but ignorant of affecting equally positive outcomes with holistic, nonlinear nutrition/natural approaches. Physicians gain most of their drug modality education from pharmaceutical reps whereby pharmacists actually learn the biochemistry and pharmacology associated with various drugs and human conditions.

6 Nutrition, to be effective, must be therapeutic, not merely present much like every drug must be titrated to a therapeutic dose to achieve the desired outcome

7 This recent article on testosterone use and its failure to improve men with impaired cognitive function is a classic example of sub-therapeutic dosing. The article concluded that, Compared with placebo, 1 year of testosterone treatment was not significantly associated with improved memory or other cognitive functions in these men. Problem was, the testers used low dose 1% testosterone gel and did not dose to a therapeutic blood/serum testosterone level. The same is true of any pharmaceutical, AND every NUTRITIONAL. Susan M. Resnick, PhD 1 ; Alvin M. Matsumoto, MD 2,3 ; Alisa J. Stephens-Shields, PhD 4 ; et al Susan S. Ellenberg, PhD 4 ; Thomas M. Gill, MD 5 ; Sally A. Shumaker, PhD 6 ; Debbie D. Pleasants, MEd 6 ; Elizabeth Barrett-Connor, MD 7 ; Shalender Bhasin, MD 8 ; Jane A. Cauley, DrPH 9 ; David Cella, PhD 10 ; Jill P. Crandall, MD 11 ; Glenn R. Cunningham, MD 12,13,14 ; Kristine E. Ensrud, MD, MPH 14,15 ; John T. Farrar, MD, PhD 16 ; Cora E. Lewis, MD, MPH 17 ; Mark E. Molitch, MD 18 ; Marco Pahor, MD 19 ; Ronald S. Swerdloff, MD 20,21 ; Denise Cifelli, MS 16 ; Stephen Anton, PhD 19 ; Shehzad Basaria, MD 6 ; Susan J. Diem, MD, MPH 14 ; Christina Wang, MD 20,21 ; Xiaoling Hou, MS 4 ; Peter J. Snyder, MD 22. Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. Author Affiliations JAMA. 2017;317(7): doi: /jama

8 There are three main characteristics to an acceptable multiple daily vit/min. What vitamins and minerals are present? What are the nutrient ratios? What are the sources for the nutrients?

9 Food quality is determined by the quality of the farming practice and the soil upon which the food is grown or the hydroponic medium in which it is grown.

10 Food toxicity also includes GMOs, pesticide residues, and nutrient content.

11 Fundamental prolo program off all dairy products: highly inflammatory ODA 4-2x HRT as needed

12 Off all diary products including cheese, yogurt, organic, natural, A2, Greek Yogurt, whey protein, caseins, lactalbumin, lactaid, lactose free, skim milk, fat free, colostrum, goat cheese, Yoda s blend or whatever one wants to name it to slip dairy in the diet

13 The only dairy derived product of use is the IgG antibody extract used for immune stimulation

14 I recommend Optimal Daily Allowance from Obrien Pharmacy at 4-2x as their foundation multi-vit-min; 2-2x for adolescents. NutriSearch judges it a one of the best on the market Helpfull for osteoporosis Look at the label, if you find something better or comparable at the price, use it. I doubt you will.

15 My third leg of prolo-prep is bioidentical hormone replacement balancing. Hormones are key to structural integrity and healing. Use troches, triest (estriol only if breast cancer patient), DHEA, testosterone and progesterone 1/2 BID sufficient to achieve therapeutic serum (not saliva) hormone levels

16 Estradiol/Estrone pg/dl Progesterone ng/dl DHEA/MS/MS Testosterone All day 21 if cycling, any day if not and 6 hours after am troche if on troche. Total estrogens mesare estrone, estradiol and xenoestrogens so don t use it to adjust HRT.

17 Testosterone Keep in mind that 40 years ago the reference range for men was up to DHEA/MS/MS Check AM as insurances require 2 morning lows to cover the script; I prefer troches bid as I can also add DHEA and does best with keeping estrogens down; next best is SQ shots of testosterone cypionate at 50mg twice weekly or q3 days, may have to address estrogens.

18 Some people don t have the motivation to do implement these changes. I explain the issues and decide whether I will treat them anyway or refer them out. I am interested in treating the hole person. I explain that if they still want to proceed, we may not get as good of results as we might. I still get reasonable results with these patients, but I select them carefully. Many I will refer them to the ortho for the conventional therapies including steroid injections which I rarely due as I do my best to abide by the hypocritical oath.

19 For those patients that joint pain/prolotherapy is only a component of their healthcare for which they have sought me, I will additionally recommend reducing red meat to once weekly, following the Fit For Life diet or Mediterranean diet with a plant based focus.

20 For those patients that are yet a bit more enlightened, I will discuss the issues of pesticides, genetically engineered foods, microwaving, trans-fats and wild caught fish.

21 Round-Up/(glyphosate) is the most widely used and available herbicide on earth Proven to cause cancer, non-alcoholic fatty liver disease (0.1ppb), to be an endocrine disrupting chemical, and antibiotic, and most importantly a strong chelating agent - its MOA.

22 Robin Mesnage, George Renney, Gilles-Eric Séralini, Malcolm Ward & Michael N. Antoniou. Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide. Scientific Reports 7, Article number: (2017) doi: /srep39328

23 Glyphosate is in many American wines, many vaccines, most conventionally grown foods in the Westernized world. It precipitates/is accompanied by a biomatrix that can only be seen under SEM which is akin to a prion infection - proven to cause infertility, spontaneous abortion, wasting disease

24 They - glyphosate/biomatrix - are the precipitators of drug resistance, malingering viral infections, and the resurgence of previously suppressed or benign diseases - e.g. Goss s Wilt in corn, spontaneous abortions in humans and animals

25 Antonietta M. Gatti, Stefano Montanari. New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination" International Journal of Vaccines and Vaccination. Volume 4 Issue National Council of Research of Italy, Institute for the Science and Technology of Ceramics, Italy 2International Clean Water Institute, USA 3Nanodiagnostics srl, Italy

26 Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case Control Study Leslie, Douglas L. et. al., the onset of certain brain-related autoimmune and inflammatory disorders has been found to be temporally associated with the antecedent administration of various vaccines. This study examines whether antecedent vaccinations are associated with increased incidence of obsessive compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder, attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder in a national sample of privately insured children. Psychiatry, 19 January

27 How do we overcome it???? Therapeutic nutrition, meaning nutritional levels and ratios sufficient for the body to compensate for and overcome the destructive/degenerative effects of these forces. Adjust and modify the nutrition per the individual genetic biochemistry - 23andme.com

Restore Balance. Three simple steps to hormone therapy that works. Feel and look great with bioidentical hormone therapy as individual as you!

Restore Balance. Three simple steps to hormone therapy that works. Feel and look great with bioidentical hormone therapy as individual as you! Restore Balance Three simple steps to hormone therapy that works Feel and look great with bioidentical hormone therapy as individual as you! Hormone therapy can alleviate the symptoms of menopause and