What is the most important information I should know about dasatinib? What should I discuss with my health care provider before taking dasatinib?
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- Jocelin Watts
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1 Generic Name: dasatinib (da SAT in ib) Brand Name: Sprycel What is dasatinib? Dasatinib is a cancer medicine that slows the growth and spread of cancer cells in the body. Dasatinib is used to treat chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) when other cancer treatments have not been effective. Dasatinib may also be used for purposes not listed in this medication guide. What is the most important information I should know about dasatinib? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my health care provider before taking dasatinib? Some people using dasatinib have developed a rare but serious condition called pulmonary arterial hypertension (PAH). PAH occurs when blood pressure increases inside the arteries in your lungs. This makes it harder for your heart to pump blood through the lungs, which also weakens muscles in the heart. PAH may be irreversible if not promptly treated, and this condition can be fatal. Talk to your doctor about your specific risk of developing PAH. To make sure dasatinib is safe for you, tell your doctor if you have: a weak immune system (caused by disease or by using certain medicine); liver disease; heart disease; a personal or family history of Long QT syndrome; lung disease; or low levels of potassium or magnesium in your blood. Dasatinib tablets contain lactose. Talk to your doctor before using this medicine if you are lactose-intolerant. Do not use dasatinib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use birth control to prevent pregnancy while you are receiving dasatinib, whether you are a man or a woman. Dasatinib use by either parent may cause birth defects. A man taking dasatinib should use a condom during any sexual activity.
2 Dasatinib may affect fertility (your ability to have children), whether you are a man or a woman. It is not known whether dasatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking dasatinib. How should I take dasatinib? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take the medicine with or without food. Take the medicine at the same time each day. Do not crush, chew, or break a dasatinib tablet. Swallow it whole. Do not use a pill that has been accidentally broken. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet or capsule. Dasatinib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not change your dose or stop using dasatinib without your doctor's advice. Store at room temperature away from moisture and heat. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while taking dasatinib? Grapefruit and grapefruit juice may interact with dasatinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking dasatinib. Avoid taking an antacid within 2 hours before or after you take dasatinib. Some antacids can make it harder for your body to absorb dasatinib. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
3 Dasatinib side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor right away if you have any symptoms of pulmonary arterial hypertension (PAH), such as: feeling tired or short of breath (even with mild exertion); swelling in your feet or lower legs; blue-colored lips and skin; and a light-headed feeling, like you might pass out. Call your doctor at once if you have: pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down); pain in your chest, on your left side, or behind your breastbone; rapid weight gain (especially in your face and midsection); low platelets or red blood cells--pale skin, feeling light-headed, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough; or other signs of bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, confusion, headache, problems with speech, extreme weakness or drowsiness. Common side effects may include: swelling, bleeding, blood cell disorders; breathing problems; headache, tiredness; nausea, diarrhea; or mild skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA See also: Side effects (in more detail) Dasatinib dosing information Usual Adult Dose for Leukemia: Chronic Phase CML: 100 mg orally once a day Duration of therapy: Until disease progression or patient is intolerant. Accelerated Phase CML, Myeloid or Lymphoid Blast Phase CML, Ph+ ALL: 140 mg orally once a day
4 Duration of therapy: Until disease progression or patient is intolerant Comments: -This drug should be used at the lowest effective dose in order to achieve therapeutic efficacy and minimize adverse effects. -The effect of discontinuing therapy after complete cytogenetic response is achieved has not been investigated. Uses: Chronic phase, accelerated phase, or myeloid or lymphoid blast phase Philadelphia chromosome-positive chronic myelogenous leukemia; Philadelphia chromosome-positive acute lymphoblastic leukemia What other drugs will affect dasatinib? Many drugs can interact with dasatinib. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with dasatinib, especially: alfentanil or fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); dexamethasone; ergotamine; nefazodone; pimozide; St. John's wort; an antibiotic--clarithromycin, rifampin, telithromycin; antifungal medicine--itraconazole, ketoconazole; a blood thinner--warfarin, Coumadin, Jantoven; HIV/AIDS medication--atazanavir, indinavir, nelfinavir, ritonavir, saquinavir; medicine to prevent organ transplant rejection--cyclosporine, sirolimus, tacrolimus; seizure medication--carbamazepine, phenobarbital, phenytoin; or stomach acid reducers--cimetidine, esomeprazole, famotidine, lansoprazole, omeprazole, ranitidine, Prevacid, Prilosec, Pepcid, Zantac, and others. This list is not complete and many other drugs can interact with dasatinib. This includes prescription and over-thecounter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Where can I get more information? Your pharmacist can provide more information about dasatinib. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
5 Copyright Cerner Multum, Inc. Version: Revision Date: , 6:23:03 AM.
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More informationMethotrexate. About This Drug. Possible Side Effects. Warnings and Precautions
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More informationFor the Patient: GIPAJGEM Other Names: Adjuvant chemotherapy for pancreatic cancer using Gemcitabine
For the Patient: GIPAJGEM Other Names: Adjuvant chemotherapy for pancreatic cancer using Gemcitabine GI = GastroIntesntinal P = Pancreatic AJ = Adjuvant GEM = Gemcitabine ABOUT THIS MEDIATION What is this
More informationORAL CHEMOTHERAPY EDUCATION
Name of your medication Generic name abiraterone acetate (A-bih-RA-the-rone A-seh-tayt) Brand name Zytiga (zye-tee-ga) Approved uses Abiraterone acetate is used in combination with prednisone to treat
More informationFor the Patient: Rituximab injection Other names: RITUXAN
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More informationFor the Patient: Cyclosporine injection Other names: SANDIMMUNE I.V.
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More informationFor the Patient: ULUAVPMTN
ABOUT THIS MEDICATION For the Patient: ULUAVPMTN Other Names: Maintenance Therapy of Advanced n-small Cell Lung Cancer (NSCLC) with Pemetrexed U = Undesignated (requires special approval) LU = LUng AV
More informationFor the Patient: Amsacrine Other names: AMSA PD
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More informationIt may be g iven to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take this drug?
PATIENT & CAREGIVER EDUCATION Pregabalin Brand Names: US Lyrica; Lyrica CR Brand Names: Canada Lyrica What is this drug used for? It is used to help control certain kinds of seizures. It is used to treat
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More informationIt is used to treat breast cancer in women after chang e of life. It may be g iven to you for other reasons. Talk with the doctor.
PATIENT & CAREGIVER EDUCATION Letrozole Brand Names: US Femara Brand Names: Canada CCP-Letrozole; Femara What is this drug used for? It is used to treat breast cancer in women after chang e of life. It
More informationAmlodipine and Celecoxib
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More informationREAD THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION. PIFELTRO doravirine tablets
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PATIENT & CAREGIVER EDUCATION Bendamustine Brand Names: US Bendeka; Treanda Brand Names: Canada Treanda What is this drug used for? It is used to treat a type of leukemia. It is used to treat a type of
More informationAcetylcysteine Injection; Acetylcysteine Solution; Mucomyst; Parvolex. It is used to thin mucus so it can be taken from the body by coughing.
PATIENT & CAREGIVER EDUCATION Acetylcysteine Brand Names: US Acetadote; Cetylev Brand Names: Canada Acetylcysteine Injection; Acetylcysteine Solution; Mucomyst; Parvolex What is this drug used for? It
More informationDo not g ive this drug if your child has an infection or any inflammation.
PATIENT & CAREGIVER EDUCATION Tisagenlecleucel Brand Names: US Kymriah Warning A very bad health problem called cytokine release syndrome (CRS) has happened with this drug. Sometimes, this has been life-threatening
More informationWhat do I need to tell my doctor BEFORE I take this drug? If you have an allerg y to ofatumumab or any other part of this drug.
PATIENT & CAREGIVER EDUCATION Ofatumumab Brand Names: US Arzerra Brand Names: Canada Arzerra Warning If you have had hepatitis B before or carry the virus, this drug can cause the virus to become active.
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More informationFor the Patient: LUAJPC
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PATIENT & CAREGIVER EDUCATION Ulipristal Brand Names: US Ella Brand Names: Canada Ella; Fibristal What is this drug used for? It is used to prevent pregnancy. It is used to treat fibroids of the uterus.
More informationValsartan and Hydrochlorothiazide
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