AOS 3: Rheumatoid Arthritis
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- Ashlie Dorsey
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1 AOS 3: Rheumatoid Arthritis Arthritis (General) = inflamed joint - NOT a single disease: covers >100 types - Involves disability + decreased quality of life o Can also occur in young people (not just the elderly) - Defined by: Pain, stiffness, swelling General Epidemiology In , 1/6 (~15%, 3.3 million) people had arthritis Prevalence higher in Indigenous populations Estimated in 2050 that 1/3 (7 million) people in Australia will be affected 95% cases accounted for by 1. Osteoarthritis (most common) 2. Rheumatoid arthritis 3. Gout Prevalence increases with age from 45 years onwards, rapid increase of affected Presents significant socio-economic costs Overview of Rheumatoid Arthritis - Chronic, inflammatory, autoimmune disease with underlying cause/trigger unknown - Predominantly disease affecting joints (i.e. articular manifestation) BUT can also affect other organ systems (extra-articular manifestations) Without treatment, get progressive disability - Decreased lifespan (3-10 years) o Leading causes of death = CDV + stroke, lymphomas (from overactive immune system) - Confined to wheelchair in years Epidemiology of RA In Caucasian populations: Incidence: 8-98 cases/100,000 people Prevalence: 0.5-1% Peak onset = 40 years old (between 40-70) Is 2-3x more common in females than males Clinical Features of RA Hallmarks of RA: Inflammation of synovium and destruction of joint tissue (cartilage and bone)
2 Synovitis Primary manifestation (where inflammation starts) of synovium If left unchecked progressive damage of all adjacent structures (erosion) Bone Cartilage Structures around joint Articular Manifestations Hallmark of inflammatory arthritis is stiffness of joint Varying Onset 1. Insidious Onset: Over weeks-months (55-65%) Gradual onset of symptoms may attribute symptoms to another cause - Morning stiffness Takes >1 hour to dispel Can get gel phenomenon if they remain inactive during the day After prolonged rest/during the night, the inflammation (oedema + inflammatory products) within joint stays stagnant = stiffness When they move = resorption of inflammatory products via lymphatics + venules back into circulation (eventually start to loosen up ) - Pain - Swelling of joint 2. Intermediate Onset: Over days-weeks (15-20%) More rapid onset of symptoms
3 3. Acute Onset: Over a few days (8-15%) Can pinpoint date they symptoms occur didn t have ANY prior Distribution of Joint Involvement - Is symmetrical - Upper limbs: o Shoulder joint o Metacarpophalangeal (MCP) o Proximal interphalangeal (PIP) o Wrist - Lower limbs: o Knee joint o Metatarsophalangeal (MTP) Equivalent to knuckle joints in feet 5 th MTP joint most commonly affected (not sure why) most common site of erosion Take x-rays upon suspicion of RA 1/3 people usually have erosions in feet before hands - Has characteristic deformities o Boutonniere o Swan neck o Z deformity o Subluxation + Ulnar deviation at MCP o Radial wrist deviation (radial joint) Basic Hand Anatomy
4 Boutonniere Deformity Mechanism of Boutonniere Deformity: Is a fixed contracture caused by splitting of extensor tendon along back surface of fingers Splitting = tendon slides down along sides of fingers - pulls fingers in contracture position PIP joint protrudes through the ruptured extensor tendon (is flexed) Can t be corrected except with surgery Swan Neck Deformity Mechanism of Swan Neck Deformity: Fixed contracture caused by splitting of flexor tendon Splitting = tendon sits on the extensor surface where it doesn t belong Forces finger into hyperflexed position tendon shortened at the DIP joint
5 MCP Subluxation + Ulnar Deviation Mechanism for MCP subluxation/ulnar deviation: Seen in untreated, long standing RA Chronic inflammation around joints that have damaged surrounding structures around each finger (supporting ligaments) slipped towards the ulnar side Slips to ulnar side because flexor muscles originate from medial epicondyle of elbow (NOTE: medial when palms facing up) - they are stronger Therefore when tendon slips, pulled towards the stronger side ulnar deviation of fingers
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