Urate Deposition in Man and its Clinical Consequences
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2 U. Gresser, N. Zöllner (Eds.) Urate Deposition in Man and its Clinical Consequences With Contributions by R. A. De Abreu, G. van den Berghe, G. Calabrese, D. J. McCarty, B. T. Emmerson, B. Gathof, M. Gonella, U. Gresser, W. Gröbner, I. Kamilli, W. Löffler, W. Mohr, G. Nuki, D. Perrett, 1. G. Puig, F. Roch Ramel, M. Schattenkirchner, K. L. Schmidt, J. T. Scott, H. A. Simmonds, O. Sperling, R. Terkeltaub, R. W. E. Watts, H. F. Woods, N. Zöllner With 53 Figures and 26 Tables Springer -Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
3 Privatdozentin Dr. Ursula Gresser Professor Dr. Nepomuk Zöllner Medizinische Poliklinik der Universität München Pettenkoferstraße 8 a, W München 2 ISBN-13 : e-isbn-13 : DOl: / This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. Springer Verlag, Berlin Heidelberg 1991 Softcover reprint of the hardcover I st edition 1991 Product Liabilitv: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceuticalliterature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. 2127/ Printed on acid-free paper
4 List of Contributors Prof. Dr. R. A. De Abreu Academisch Ziekenhuis Nijmegen, Sint-Radboudziekenhuis, Postbus 9101, NL-6500 HB Nijmegen Prof. Dr. G. van den Berghe International Institute of Cellular and Molecular Pathology, UCL 7539, Avenue Hippocrate 75, B-1200 Bruxelles Dr. G. Calabrese Servizio di Nefrologia e Dialisi, Ente Ospedaliero, Casale Monferrato (Al) Prof. Dr. D. J. McCarty Medical College of Wisconsin, 8700 W. Wisconsin Ave., Milwaukee Wi , USA Prof. Dr. B. T. Emmerson University of Queensland, Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia Dr. B. Gathof Medizinische Poliklinik der Universität München, Pettenkoferstr. 8 a, Prof. Dr. M. Gonella Servizio di Nefrologia e Dialisi, Ente Ospedaliero, Casale Monferrato Priv.-Doz. Dr. Ursula Gresser Medizinische Poliklinik der Universität München, Pettenkoferstr. 8 a, Prof. Dr. W. Gräbner Kreiskrankenhaus Balingen, Tübinger Str. 30, D-7460 Balingen
5 VI List ofcontributors Dr. 1. Kamilli Medizinische Poliklinik der Universität München, Pettenkoferstr. 8 a, Priv.-Doz. Dr. W. Löffler Städt. Krankenhaus M-Bogenhausen, Englschalkinger-Str. 27, D-8000 München 81 Prof. Dr. W. Mohr Abteilung Pathologie der Universität Ulm, Albert-Einstein-Allee 11, D-7900 Ulm Prof. Dr. G. Nuki Rheumatic Diseases Unit, Northern General Hospital, Ferry Road, Edinburgh EHS 2DQ, Großbritannien Dr. D. Perrett Dept. of Medicine, St. Bartholomew's Hospital, London EC I A 7 BE, Great Britain Prof. Dr. J. G. Puig Hospital "La Paz" Costa Brava 2330 D, E Madrid Prof. Dr. F. Roch-Ramel Institut de Pharmacologie et de Toxicologie de I'Universite de Lausanne, Rue de Bugnon 27, CH-lOOS Lausanne Prof. Dr. M. Schattenkirchner Medizinische Poliklinik der Universität München, Pettenkoferstraße 8 a, Prof. Dr. K. Schmidt Klinik für Physikalische Medizin, Balneologie und Rheumatologie am Klinikum der Justus-Liebig-Universität Gießen Bad Nauheim, Ludwigstr , D-63S0 Bad Nauheim Prof. Dr. J. T. Scott Charing Cross Hospital, Department of Rheumatology, Fulham Palace Road, Hammersmith, London W6 8RF, Großbritannien Prof. Dr. H. A. Simmonds Clinical Science Laboratories, Guy's Tower (17th and 18th Floors), Guy's Hospital, London Bridge, SEI 9RT, Großbritannien
6 List of Contributors VII Prof. Dr. O. Sperling Beilinson Medical Center, School ofmedicine, Tel-Aviv University, Petah-Tiqva, Israel Prof. Dr. R. Terkeltaub Rheum. Section, V. A. Medical Center, III-K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA Prof. Dr. R. W. E. Watts 14, Holly Lodge Gardens, Highgate, London N6 6AA, Großbritannien Prof. Dr. H. F. Woods The University of Sheffield, Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Glossop Road, Sheffield S 10 2JF, Großbritanmen Prof. Dr. N. Zöllner Medizinische Poliklinik der Universität München, Pettenkoferstr. 8 a,
7 Contents The Study of Inborn Errors of Metabolism - 40 Years of Experience at the Poliklinik of the University of Munich (N. Zöllner) The Enigma ofurate Deposition (H. F. Woods) Precipitation and Deposition of Monosodium Urate Monohydrate Crystals in Tissues (D. 1. McCarty) Urate Depositions in Tissues (W. Mohr) 24 4 Renal Consequences of Hyperuricemia (M. Gonella, G. Calabrese) Urate and Uric Acid Crystal Reactions Within the Kidney- Clinical and Experimental Studies (B. T. Emmerson) Urate Deposition and Stone Formation in the Kidney in Renal Hypouricemia (0. Sperling) Acute Renal Insufficiency: Which Mechanisms Are Involved? (R. A. De Abreu) Epidemiology of Hyperuricaemia (U. Gresser, B. Gathof) Pathogenesis of Monosodium Urate Crystal-Induced Inflammation (R. Terkeltaub) Crystal-Associated Inflammation: Some Mechanisms of Cellular Activation (G. Nuki) The Course of Chronic Gout with Special Reference to Extra-articular Manifestations and Joints Not Affected by Acute Attacks (1. T. Scott) The Course of Chondroca1cinosis (M. Schattenkirchner)
8 x Contents 10 Round Table Discussion Subject Index
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