DERBY-BURTON LOCAL CANCER NETWORK FILENAME R-IVE.DOC CONTROLLED DOC NO: HCCPG B53 CSIS Regimen Name: R-IVE. R-IVE Regimen
|
|
- Rudolf Price
- 5 years ago
- Views:
Transcription
1 R-IVE Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Relapsed/ refractory high grade non-hodgkin s lymphoma Treatment Intent Salvage, or prior to stem cell mobilisation Anti-Emetics Pre-chemotherapy 3 Post-chemotherapy A + Ondansetron 8mg twice daily for 5 days Frequency & Duration Every 21 days(or upon recovery of bone marrow) for a maximum of 6 cycles Day 0 Phenytoin 300mg Oral at night for 6 days Allopurinol 300mg Oral once daily for 1-2 cycles Paracetamol 1g As a single oral dose 30 minutes prior to rituximab Chlorphenamine 10mg As a single intravenous dose 30 minutes prior to rituximab Hydrocortisone 100mg As a single intravenous dose 30 minutes prior to rituximab Prednisolone 100mg As a single oral dose 30 minutes prior to rituximab Rituximab 375mg/m 2 Intravenous infusion in 500ml 0.9% sodium chloride Sodium chloride 1 litre Intravenous infusion over 6 hours 0.9% Sodium chloride 1 litre Intravenous infusion over 6 hours 0.9% Sodium chloride 1 litre Intravenous infusion over 6 hours 0.9% Day 1 Ondansetron 8mg As a single oral or intravenous dose prior Dexamethasone 8mg As a single oral or intravenous dose prior Epirubicin 50mg/m 2 Intravenous bolus Etoposide 200mg/m 2 Intravenous infusion in 1000ml sodium chloride 0.9% over 2 hours Mesna 1800mg/m 2 Intravenous infusion in 100ml sodium chloride 0.9% over 10 minutes REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 1 of 6
2 Ifosfamide & Mesna Intravenous infusion in 2000ml sodium chloride 0.9% (2 x 1000ml infusion bags) over 22 hours Aciclovir 400mg Oral twice daily until lymphocytes >1 x 10 9 /l Cotrimoxazole 480mg Oral ONce daily until lymphocytes >1 x 10 9 /l Omeprazole 20mg Oral once daily for 21 days Metoclopramide 10mg Oral four times daily as required Ondansetron 8mg Oral twice daily for 5 days Day 2 Dexamethasone 8mg As a single oral or intravenous dose prior Etoposide 200mg/m 2 Intravenous infusion in 1000ml sodium chloride 0.9% over 2 hours Ifosfamide & Mesna Intravenous infusion in 2000ml sodium chloride 0.9% (2 x 1000ml infusion bags) over 22 hours Day 3 Dexamethasone 8mg As a single oral or intravenous dose prior Etoposide 200mg/m 2 Intravenous infusion in 1000ml sodium chloride 0.9% over 2 hours Ifosfamide & Mesna Intravenous infusion in 2000ml sodium chloride 0.9% (2 x 1000ml infusion bags) over 22 hours Day 4 Mesna 5400mg/m 2 Intravenous infusion in 1000ml dextrose 4% & sodium chloride 0.18% over 12 hours Day 5 Or Day 8 G-CSF (Lenograstim) G-CSF (Filgrastim) 263 micrograms (BSA <1.8m 2 ) Or 368 micrograms (BSA >1.8m 2 ) 300 micrograms Subcutaneous injection ONCE daily until adequate stem cell harvest Subcutaneous injection ONCE daily until neutrophils > 1.0 x 109/L (non-mobilizing cycle) REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 2 of 6
3 Notes: Baseline investigations It is recommended that patients receive pre-hydration with 3 litres of sodium chloride 0.9% over 18 hours Rituximab This section should be read in conjunction with the Guidelines for the administration of Rituximab. 1. The day 1 dose of prednisolone should be given 30 mins prior to receiving rituximab. Premedication consisting of analgesia and an antihistamine and an intravenous corticosteroid should always be administered 30 minutes before each infusion of rituximab, (e.g. paracetamol 1g oral STAT and chlorphenamine 4mg oral or 10mg IV bolus STAT and hydrocortisone 100mg IV STAT). In addition pethidine 25mg IV should be available in case of a severe infusion reaction 2. Rituximab doses should be rounded to the nearest 100mg Use rituximab rate calculator to assist with rate escalation of rituximab infusion 3. Occurrence of an Infusion Related Event or Hypersensitivity: Stop the infusion and contact a doctor. When symptoms improve, continue the infusion at half the rate prior to the reaction. Accelerate the infusion rate more slowly as tolerated by the patient. Dose modifications and toxicities 1. Haematological toxicity Delay treatment until neutrophils > 1.0x10 9 /l and platelets > 100x10 9 /l unless cytopenias are considered to be disease-related. 2. Renal impairment GFR ml/min Ifosfamide Dose Etoposide Dose > 60 Full dose Full dose % of dose 80% of dose < 40 Clinical decision Clinical decision REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 3 of 6
4 3. Hepatic impairment Epirubicin Serum bilirubin Epirubicin Dose micromol/l 0-20 Full dose % dose % dose >85 Omit Etoposide Bilirubin AST/ALT micromol/l IU/L Etoposide Dose % >51 >180 omit Consider dose reduction of ifosfamide in patients with significant hepatic dysfunction. 4. Neurotoxicity Ifosfamide may cause a reversible encephalopathy at high doses. This usually manifests as decreased rousability and disorientation often leading to somnolence. In severe cases this can progress to irreversible encephalopathy and death. Symptoms may develop within 2 hours of initiation or up to 28 days after treatment; the usual onset is within hours after the initiation of ifosfamide and disappears within hours of discontinuing ifosfamide. Risk factors include: Elevated serum creatinine Previous exposure to cisplatin (cumulative dose >300mg/m 2 ) Low serum albumin Previous exposure to ifosfamide Abdominal lymphoma Short ifosfamide infusions (<6hrs) Prior cranial irradiation Other CNS-active drugs REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 4 of 6
5 If a patient is at risk of developing encephalopathy, consideration should be given to the use of an alternative (non-ifosfamide containing) regimen. Management of ifosfamide-induced encephalopathy 1. Discontinue ifosfamide. 2. Consider use of methylthioninium chloride (methylene blue) (Unlicensed indication): 50mg slow intravenous bolus over 5 minutes. This may need to repeated up to 6 times/day. Methylthioninium chloride is available as a 0.5% solution; 10ml of 0.5% solution is equivalent to 50mg. The 0.5% solution does not require filtering, and is incompatible with sodium chloride 0.9% so will need to be diluted in 5% dextrose if dilution is necessary. 3. In patients who have had a history of ifosfamide-induced encephalopathy and require further doses of ifosfamide, methylthioninium chloride has been used prophylactically (50mg slow intravenous bolus over 5 minutes 4 times daily). 4. Haloperidol & lorazepam have been reported to help with hallucinations and agitation. Use with caution, -no controlled trials exist and these agents may mask the evolution or severity of neurotoxicity. Methylthioninium chloride frequently colours secretions blue, patients should be made aware of this effect 4. Haemorrhagic Cystitis Urine should be dipstick tested for signs of haematuria. If microscopic haematuria is present, an increase in hydration can be used to facilitate the elimination of ifosfamide and its metabolites. Additional mesna appears to have little benefit as its role is in prevention rather than treatment. However, owing to its low toxicity consideration should be given to increasing the dose of mesna (although arbitrary, local practice is to double the dose). In the case of frank haematuria, a urological opinion should be sought. Mesna is of little value at this point as it s role is to prevent haemorrhagic cystitis and not for its treatment. REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 5 of 6
6 Supportive care 1. It is advisable to give allopurinol (300mg) once a day for the first 1 or 2 courses of therapy whilst there is bulky disease. Reduce dose to 100mg daily if GFR <10mls/min. 2. All patients should receive Pneumocystis jiroveci prophylaxis throughout treatment:: Co-trimoxazole 480mg ONCE daily. In cases of allergy to co-trimoxazole, consider dapsone 100mg daily. 3. Aciclovir 400mg twice daily. 4. Omeprazole 20mg once daily. References 1. McQuaker IG et al.; Stem cell mobilization in resistant or relapsed lymphoma: superior yield of progenitor cells following a salvage regimen comprising ifosphamide, etoposide and epirubicin compared to intermediate-dose cyclophosphamide; Br J Haematol.; 1997; 98: REVIEWED BY C.WARD AUTHORISED BY: Dr J Addada PAGE 6 of 6
R-ICE Regimen- Rituximab, Etoposide, Ifosfamide (with MESNA), Carboplatin (+ Depocyte if CNS involvement)
R-ICE Regimen- Rituximab, Etoposide, Ifosfamide (with MESNA), Carboplatin (+ Depocyte if CNS involvement) Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME ESHAP.DOC CONTROLLED DOC NO: HCCPG B44. ESHAP Regimen
ESHAP Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Relapsed/ refractory
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME SMILE.DOC CONTROLLED DOC NO: HCCPG B57 CSIS Regimen Name: SMILE. SMILE chemotherapy
SMILE chemotherapy Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Extranodal
More informationRituximab-CHOP Regimen - ENRICH Study
Rituximab-CHOP Regimen - Study Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma ***See protocol for further details***
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME R-GCVP.DOC CONTROLLED DOC NO: HCCPG B12 CSIS Regimen Name: R-GCVP. R-GCVP Regimen
R-GCVP Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication CD 20 positive
More informationRituximab, Gemcitabine, Dexamethasone and Cisplatin RGDP Regimen
Rituximab, Gemcitabine, Dexamethasone and Cisplatin RGDP Regimen Available for Routine Use in Burton in-patient N/A Derby in-patient Burton day-case Derby day-case Burton outreach chemotherapy clinic N/A
More informationNordic Protocol (MaxiCHOP/R-MaxiCHOP plus R-HDAraC)
Nordic Protocol (MaxiCHOP/R-MaxiCHOP plus R-HDAraC) Available for Routine Use in Burton in-patient Derby in-patient (First cycle if bulky disease & risk of tumour lysis syndrome) Burton day-case Derby
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME R-CODOX-M.DOC CONTROLLED DOC NO: HCCPG B115 CSIS Regimen Name: R-CODOXM. Rituximab + CODOX-M
Rituximab + CODOX-M Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Burkitt
More informationFludarabine + Cyclophosphamide + Rituximab (FCR) - FLAIR Study
Fludarabine + Cyclophosphamide + Rituximab (FCR) - FLAIR Study Front-Line therapy in CLL: Assessment of Ibrutinib-containing Regimes. ***See protocol for further details*** Available for Routine Use in
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME CEOP.DOC CONTROLLED DOC NO: HCCPG B21 CSIS Regimen Name: CEOP. CEOP Regimen
CEOP Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication T-cell non-hodgkin
More informationR-BAC-500 (Rituximab, Bendamustine, Cytarabine) for Mantle Cell Lymphoma
R-BAC-500 (Rituximab, Bendamustine, Cytarabine) for Mantle Cell Lymphoma Not routinely commissioned, each case requires prior documented approval before offering & commencing therapy from NHS England Cancer
More informationGemcitabine, Dexamethasone and Cisplatin GDP Regimen
Gemcitabine, Dexamethasone and Cisplatin GDP Regimen Available for Routine Use in Burton in-patient N/A Derby in-patient Burton day-case Derby day-case Burton outreach chemotherapy clinic N/A Derby outreach
More informationIBRUTINIB + Rituximab, Treatment Period - ENRICH Study
IBRUTINIB + Rituximab, Treatment Period - Study Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma ***See protocol for further
More informationHigh Dose Cytarabine plus high dose Methotrexate for CNS Lymphoma
High Dose Cytarabine plus high dose Methotrexate for CNS Lymphoma Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton
More informationFLAG-Ida + Gemtuzumab Ozogamicin Regimen (Also known as FLAG-Ida + GO3x2) (AML19 Trial Course 1)
FLAG-Ida + Gemtuzumab Ozogamicin Regimen (Also known as FLAG-Ida + GO3x2) (AML19 Trial Course 1) AML19 Adults with Acute Myeloid Leukaemia or High-Risk Myelodysplastic Syndrome ***Refer to trial protocol
More informationE 90 C followed by Weekly Paclitaxel
E 90 C followed by Weekly Paclitaxel Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient
More informationTIP Paclitaxel, Ifosfamide and Cisplatin
Systemic Anti Cancer Treatment Protocol TIP Paclitaxel, Ifosfamide and Cisplatin PROTOCOL REF: MPHATIPGC (Version No: 1.0) Approved for use in: Second line treatment of germ cell tumours Dosage: Drug Dosage
More informationDERBY-BURTON CANCER NETWORK CONTROLLED DOC NO:
OBINUTUZUMAB+CHLORAMBUCIL Regimen RDH; Day 1 and 2 Dose to be given on Ward Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community
More informationObinutuzumab+Bendamustine followed by Obinutuzumab Maintenance Burton in-patient Derby in-patient Burton day-case Derby day-case
Obinutuzumab+Bendamustine followed by Obinutuzumab Maintenance Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Available
More informationX M/ (R) Dose adjusted (DA)-EPOCH-R
X M/ (R) adjusted (DA)-EPOCH-R Indication High-risk CD20+ diffuse large B cell lymphoma especially C-MYC and BCL-2 activated (i.e. double hit lymphoma) and mediastinal sclerosing (thymic) large B cell
More informationVincristine Ifosfamide Doxorubicin Etoposide (VIDE) Sarcoma
Systemic Anti Cancer Treatment Protocol Vincristine Ifosfamide Doxorubicin Etoposide (VIDE) Sarcoma PROTOCOL REF: MPHAVIDE (Version No: 1.0) Approved for use in: Ewings sarcoma Desmoplastic small round
More informationR-GDP: Rituximab, Gemcitabine, Dexamethasone &Cisplatin
: Rituximab, &Cisplatin INDICATION Relapsed or refractory Hodgkin and non-hodgkin lymphoma. Omit Rituximab for patients with Hodgkin Lymphoma. TREATMENT INTENT Palliative or curative depending on context.
More informationSubcutaneous Rituximab with or without Ibrutinib, Maintenance Period - ENRICH Study
Subcutaneous Rituximab with or without Ibrutinib, Maintenance Period Study Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma
More informationTIP: Paclitaxel / Ifosfamide / Cisplatin in Relapsed Germ Cell Tumour
TIP: Paclitaxel / Ifosfamide / Cisplatin in Relapsed Germ Cell Tumour Indication: Second line therapy in Relapsed Germ Cell Tumours Regimen details: Paclitaxel 175mg/m 2 IV Cisplatin 20mg/m 2 IV - D5 Ifosfamide
More informationDoxorubicin and Ifosfamide Sarcoma
Systemic Anti Cancer Treatment Protocol Doxorubicin and Ifosfamide Sarcoma PROTOCOL REF: MPHADOXIFO (Version No:.0) Approved for use in: Soft tissue sarcoma Dosage: Drug Dosage Route Frequency Doxorubicin
More informationSUBCUTANEOUS Bortezomib + Thalidomide +Dexamethasone Available for Routine Use in
SUBCUTANEOUS Bortezomib + Thalidomide +Dexamethasone Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby
More informationCD20-positive high-grade non-hodgkin Lymphoma in patients in which R-CHOP is not indicated
INDICATION CD20-positive high-grade non-hodgkin Lymphoma in patients in which R-CHOP is not indicated TREATMENT INTENT Curative or Disease Modification. PRE-ASSESSMENT 1. Ensure histology is confirmed
More informationThis is a controlled document and therefore must not be changed or photocopied L.80 - R-CHOP-21 / CHOP-21
R- / INDICATION Lymphoma Histiocytosis Omit rituximab if CD20-negative. TREATMENT INTENT Disease modification or curative depending on clinical circumstances PRE-ASSESSMENT 1. Ensure histology is confirmed
More informationR-IDARAM. Dexamethasone is administered as an IV infusion in 100mL sodium chloride 0.9% over 30 minutes.
R-IDARAM Indication Secondary CNS lymphoma ICD-10 codes Codes with a prefix C85 Regimen details Day Drug Dose Route 1 Rituximab 375mg/m 2 IV infusion 1 Methotrexate 12.5mg Intrathecal 1 Cytarabine 70mg
More informationR-GDP: Rituximab, Gemcitabine, Dexamethasone &Cisplatin
: Rituximab, Gemcitabine, Dexamethasone &Cisplatin INDICATION Relapsed or refractory Hodgkin and non-hodgkin lymphoma. Omit Rituximab for patients with Hodgkin Lymphoma or high grade T cell non-hodgkin
More information(R) CHOEP. May be used for stage IA - IV Diffuse Large B Cell non-hodgkin lymphoma in combination with rituximab.
(R) CHOEP Indication Treatment of stage IA - IV T cell non-hodgkin lymphoma as an alternative to CHOP in younger, fitter patients with normal LDH level. May be used for stage IA - IV Diffuse Large B Cell
More information(R) CODOX M / (R) IVAC
(R) CODOX M / (R) IVAC Indication Burkitt's or Burkitt's-like lymphoma, especially those with 1 or more of the following poor risk criteria: - Raised LDH level - WHO performance status 2-4 - Ann Arbor
More informationBurkitt lymphoma, double hit lymphoma or high IPI diffuse large B-cell lymphoma.
INDICATION Burkitt lymphoma, double hit lymphoma or high IPI diffuse large B-cell lymphoma. TREATMENT INTENT Curative. PRE-ASSESSMENT 1. Ensure histology is confirmed prior to administration of chemotherapy
More informationVIP (Etoposide, Ifosfamide and Cisplatin)
VIP (Etoposide, Ifosfamide and Cisplatin) Indication First line treatment for metastatic seminoma, non seminoma or combined tumours where bleomycin is contra-indicated. Usually used for patients with intermediate
More informationDA-EPOCH-R (Etoposide/Inpatient)
DA- (Etoposide/Inp) INDICATION High grade lymphoma. Omit rituximab if CD20 negative. PRE-ASSESSMENT 1. Ensure histology is confirmed prior to administration of chemotherapy and document in notes. 2. Record
More informationBevacizumab + Paclitaxel + Cisplatin
Bevacizumab + Paclitaxel + Cisplatin Available for Routine Use in Not routinely commissioned, each case requires prior documented approval before offering & commencing therapy from the Cancer Drugs Fund
More informationMATRIX (Methotrexate, Cytarabine, Thiotepa and Rituximab)
MATRIX (Methotrexate, Cytarabine, Thiotepa and Rituximab) Indication First line treatment of primary CNS lymphoma. ICD-10 codes Codes with a prefix C85 Regimen details Day Drug Dose Route 1 and 6 Rituximab
More informationBurkitt s Lymphoma or DLBCL with adverse features PATIENTS WITH GOOD PERFORMANCE STATUS
Regimen R-CODOX M Indication Burkitt s Lymphoma or DLBCL with adverse features Therapeutic Intent Radical/Curative PATIENTS WITH GOOD PERFORMANCE STATUS Day Medication Dose Route Administration Details
More informationGemcitabine + Cisplatin Regimen
Gemcitabine + Cisplatin Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication
More informationO-CVP with maintenance Obinutuzumab
with maintenance Obinutuzumab INDICATION Follicular Lymphoma: 1 st line treatment in advanced symptomatic patients (NICE TA513 for FLIPI score 2 or higher - BLUETEQ required) TREATMENT INTENT Disease modification.
More informationULYRICE. Protocol Code. Lymphoma. Tumour Group. Dr. Laurie Sehn. Contact Physician
BCCA Protocol Summary for the Treatment of Relapsed or Refractory Advanced Stage Aggressive B-Cell Non-Hodgkin s Lymphoma with Ifosfamide, CARBOplatin, Etoposide and rituximab Protocol Code Tumour Group
More informationBreast Pathway Group EC x 4 Paclitaxel x 4 (3-weekly): Epirubicin & Cyclophosphamide x 4 followed by Paclitaxel x 4 (3-weekly) in Early Breast Cancer
Breast Pathway Group EC x 4 Paclitaxel x 4 (3-weekly): Epirubicin & Cyclophosphamide x 4 followed by Paclitaxel x Indication: Neoadjuvant or adjuvant therapy for moderate to high risk node positive breast
More informationNote: There are other bendamustine protocols, ensure this is the correct one for a given patient.
INDICATIONS 1 st line treatment for follicular lymphoma with FLIPI score 2 or higher: (NICE TA513- BLUETEQ required) Rituximab refractory follicular lymphoma (progression on R-chemo, R-maintenance or within
More informationNCCP Chemotherapy Regimen. TICE - Autologous Conditioning Germ Cell Tumour Regimen
TICE - Autologous INDICATIONS FOR USE: Regimen INDICATION ICD10 Code Treatment of metastatic relapsed/refractory germ cell tumours C62 00437a *Reimbursement Indicator If a reimbursement indicator (e.g.
More informationNB. This version combines both previous inpatient and ambulatory protocols. See DRUG REGIMEN section for details.
DA- INDICATION High grade lymphoma. Omit rituximab if CD20 negative. NB. This version combines both previous inpatient and ambulatory protocols. See DRUG REGIMEN section for details. TREATMENT INTENT Curative
More informationLung Pathway Group Cisplatin & IV Vinorelbine in Non- Small Cell Lung Cancer (NSCLC)
Lung Pathway Group Cisplatin & IV Vinorelbine in Non- Small Cell Lung Cancer (NSCLC) Indication: First line in radical/induction treatment in locally advanced NSCLC First line palliative treatment in advanced/metastatic
More informationBreast Pathway Group EC x 4 Docetaxel x 4: Epirubicin & Cyclophosphamide followed by Docetaxel in Early Breast Cancer
Breast Pathway Group EC x 4 Docetaxel x 4: Epirubicin & Cyclophosphamide followed by Docetaxel in Early Breast Indication: Neoadjuvant therapy for high risk and fit breast cancer patients suitable for
More informationGemcitabine & Cisplatin
Gemcitabine & Cisplatin Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Advanced
More informationBevacizumab + Paclitaxel & Carboplatin
Bevacizumab + Paclitaxel & Carboplatin Available for Routine Use in Not routinely commissioned, each case requires prior documented approval before offering & commencing therapy from NHS England Cancer
More informationNCCP Chemotherapy Regimen
DOXOrubicin, Cyclophosphamide (AC 60/600) 21 day followed by weekly PACLitaxel (80) Therapy (AC-T) Note: There is an option for Dose Dense DOXOrubicin, cyclophosphamide PACLitaxel (DD AC T) therapy described
More informationR-GemOx. Lymphoma group INDICATION. Relapsed or Refractory Lymphoma, for patients unsuitable for R-GDP regimen. Omit rituximab if CD20- negative
R-GemOx INDICATION Relapsed or Refractory Lymphoma, for patients unsuitable for R-GDP regimen. Omit rituximab if CD20- negative TREATMENT INTENT Disease modification PRE-ASSESSMENT 1. Ensure histology
More informationCisplatin Vinorelbine (Oral) therapy +/- radiotherapy
1 REGIMEN TITLE: Cisplatin Vinorelbine (Oral) therapy +/- radiotherapy Page 1 of 5 Indication: First line in Radical/ Induction, Adjuvant and Advanced & Palliative treatment of Non-small cell lung cancer
More informationGemcitabine + Capecitabine (ESPAC-4 Trial)
Gemcitabine + Capecitabine (ESPAC-4 Trial) European Study Group For Pancreatic Cancer - Trial 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and ampullary cancers. ***
More informationEC (Epirubicin Cyclophosphamide) Adjuvant/Neo-adjuvant regimen
y Systemic Anti Cancer Treatment Protocol EC (Epirubicin Cyclophosphamide) Adjuvant/Neo-adjuvant regimen PROTOCOL REF: MPHAECANBR (Version No: 1.0) Approved for use in: ER positive, HER2 negative ( Luminal
More information(High dose METHOTREXATE, high dose CYTARABINE, RITUXIMAB and THIOTEPA)
MATRix (High dose METHOTREXATE, high dose CYTARABINE, RITUXIMAB and THIOTEPA) INDICATION CNS Lymphoma. TREATMENT INTENT Curative. PRE-ASSESSMENT 1. Ensure histology is confirmed and documented in the notes.
More informationLung Pathway Group Cisplatin & PO Vinorelbine in Non- Small Cell Lung Cancer (NSCLC)
Lung Pathway Group Cisplatin & PO Vinorelbine in Non- Small Cell Lung Cancer (NSCLC) Indication: First line in radical/induction treatment in locally advanced NSCLC First line palliative treatment in advanced/metastatic
More informationIVE for relapsed or primary refractory Hodgkin s lymphoma / Diffuse Large B Cell Lymphoma (LYMWOS004/1)
West of Scotland Cancer Network Chemotherapy Protocol IVE for relapsed or primary refractory Hodgkin s lymphoma / Diffuse Large B Cell Lymphoma (LYMWOS004/1) Indication Salvage chemotherapy for relapsed
More informationFludarabine-Cyclophosphamide plus Rituximab (FC-R) for Chronic Lymphocytic Leukaemia
DRUG ADMINISTRATION SCHEDULE First Cycle Only: Day Drug Dose Route Diluent Rate 1 Paracetamol 1gram Oral 1 Hydrocortisone 100mg IV bolus 1 Chlorphenamine 10mg IV bolus 1 Rituximab 375mg/m 2 IV infusion
More informationPVACE-BOP (Hodgkin s Lymphoma)
DRUG ADMINISTRATION SCHEDULE Day Drug Dose Route Diluent Rate 1 Ondansetron 8mg IV / Oral vinblastine 6mg/m 2 (Max: 10mg) IV Infusion Etoposide 100mg/m 2 IV infusion Patients over 65 years by 15 min infusion
More informationNCCP Chemotherapy Regimen. Dose Dense DOXOrubicin, Cyclophosphamide (AC 60/600) 14 day followed by PACLItaxel (175) 14 day Therapy (DD AC-T)
Dose Dense DOXOrubicin, Cyclophosphamide (AC 60/600) 14 day followed by PACLItaxel (175) 14 day Therapy (DD AC-T) Note: There is an option for DOXOrubicin, cyclophosphamide followed by weekly PACLItaxel
More informationNCCP Chemotherapy Protocol. CHOEP Therapy 21 days. Treatment of T-cell Non-Hodgkins Lymphoma C a
CHOEP Therapy 21 days INDICATIONS FOR USE: INDICATION ICD10 Protocol Code Treatment of T-cell Non-Hodgkins Lymphoma C85 00396a ELIGIBILTY: Indication as above Age < 60 years Adequate haematological, renal
More informationPaclitaxel/Carboplatin with dose dense EC Neoadjuvant Regimen
Systemic Anti Cancer Treatment Protocol Paclitaxel/Carboplatin with dose dense EC Neoadjuvant Regimen PROTOCOL REF: MPHAPCECBR (Version No: 1.0) Approved for use in: Neoadjuvant treatment of operable,
More informationDTPACE. Myeloma group INDICATION
INDICATION Relapsed or refractory myeloma patients suitable for intensive salvage chemotherapy. Plasma cell leukaemia or presentation with extra-medullary disease. TREATMENT INTENT Disease Modification
More informationCarboplatin + Paclitaxel Cancer of the Cervix
Carboplatin + Paclitaxel Cancer of the Cervix Background: Topotecan in combination with cisplatin is recommended as a treatment option for women with recurrent or stage IVB cervical cancer only if they
More information2.07 Protocol Name: CHOP & Rituximab
2.07 Protocol Name: CHOP & Rituximab Indication Intermediate and high grade, B-cell non-hodgkins lymphoma expressing CD20. Second or third line therapy for low grade, B cell non- Hodgkins lymphoma expressing
More information4.05 Protocol name: Alemtuzumab (MabCampath ), intravenous
4.05 Protocol name: (MabCampath ), intravenous Indication Treatment of CLL refractory to fludarabine (either primary i.e. 17p deletion, or secondary i.e. following previous fludarabine treatment), without
More informationBreast Pathway Group EC x 4: Epirubicin & Cyclophosphamide in Early Breast Cancer
Breast Pathway Group EC x 4: & in Early Breast Cancer Indication: Neoadjuvant or adjuvant treatment for moderate to high risk breast cancer Regimen details: 90 mg/m 2 IV Day 1 600 mg/m 2 IV Day 1 Administration:
More information1 Acute Lymphoblastic Leukaemia
1 Acute Lymphoblastic Leukaemia 1.05 Intensification - Philadelphia Negative Patients Indication ALL Philadelphia negative patients Pre-treatment Evaluation The intensification module begins two weeks
More informationSMILE (Etoposide, Ifosfamide, Methotrexate and Dexamethasone)
SMILE (Etoposide, Ifosfamide, Methotrexate and Dexamethasone) INDICATION Natural Killer/T-cell lymphoma TREATMENT INTENT Curative SPECIAL PRECAUTIONS This protocol causes marked myelosuppression despite
More informationGuidelines for the administration of Rituximab
the administration of 1. Introduction Administration of the anti-cd20 monoclonal antibody is associated with severe hypersensitivity reactions, potentially life threatening cytokine release syndrome, and
More informationADULT Updated: September 4, 2018
Updated: September 4, 2018 Regimen Reference Order ARIA: LYMP [R-CHOP alt. R-DHAP] Planned Course: Indication for Use: Every 21 days for 6 cycles (R-CHOP given on cycles 1, 3 and 5; R-DHAP given on cycles
More informationWeekly Cisplatin + Radiotherapy - Interlace study -
Weekly Cisplatin + Radiotherapy - Interlace study - A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with
More informationNCCP Chemotherapy Regimen. Dose Dense DOXOrubicin, Cyclophosphamide (AC 60/600) 14 day followed by PACLitaxel (80) 7 day Therapy (DD AC-T)
Dose Dense DOXOrubicin, Cyclophosphamide (AC 60/600) 14 day followed by PACLitaxel (80) 7 day Therapy (DD AC-T) INDICATIONS FOR USE: INDICATION Adjuvant Treatment of High Risk Node Negative or Node Positive
More informationECX. Anti-emetics: Day 1: highly emetogenic Days 2 21: mildly emetogenic
Page 1 of 5 As an alternative to ECF: For locally advanced (inoperable) or metastatic oesophageal or gastric cancer; peri-operative use in oesophageal or gastric cancer; adenocarcinoma of unknown primary
More informationBEAM. Lymphoma group OxBMT SCHEDULE SUMMARY. Date:
xbt SCHEDULE SUARY Date: Day DRUG -7-6 -5-4 -3-2 -1 0 +1 Admission Carmustine (BCNU) Etoposide Cytarabine (Ara-C) elphalan Stem cell infusion Pentamidine* To prevent a specific pneumonia called PCP Cyclizine
More informationDurvalumab (previously known as MEDI 4736) Maintenance (Arm A3) PLATFORM study
Durvalumab (previously known as MEDI 4736) Maintenance (Arm A3) PLATFORM study PLAnning Treatment For Oesophago-gastric cancer: a Randomised Maintenance therapy trial. ***See Protocol for further details***
More informationNECN CHEMOTHERAPY HANDBOOK PROTOCOL
DRUG ADMINISTRATION SCHEDULE Day Drug Dose Route Diluent Rate 1* to 5 Prednisolone 40mg/m 2 Oral Once Daily For 5 days 1 Paracetamol 1gram Oral Once Only Chlorphenamine 10mg IV bolus Ondansetron 8mg IV
More informationDocetaxel + Nintedanib
Docetaxel + Nintedanib Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Second
More informationALL Phase 2 Induction (25-60 years)
ALL Phase 2 (25-60 years) INDICATION of remission in Adult Acute Lymphoblastic Leukaemia (ALL) patients This protocol is suitable for patients aged 25-60 years. It may sometimes be used in older patients
More informationNCCP Chemotherapy Regimen. DOXOrubicin, Cyclophosphamide (AC 60/600) 21 day followed by weekly PACLitaxel (80) and weekly Trastuzumab Therapy (AC-TH)
DOXOrubicin, Cyclophosphamide (AC 60/600) 21 day followed by weekly PACLitaxel (80) and weekly Trastuzumab Therapy (AC-TH) Note: There is an option for Dose Dense DOXOrubicin, cyclophosphamide PACLitaxel
More informationCISPLATIN Chemo-radiation regimen Gynaecological Cancer
Systemic Anti Cancer Treatment Protocol CISPLATIN Chemo-radiation regimen Gynaecological Cancer PROCTOCOL REF: MPHAGYNCIX (Version No: 1.0) Approved for use in: Locally advanced cervical cancer (adjuvant/curative)
More informationO-CHOP with Obinutuzumab maintenance
O-CHOP with Obinutuzumab maintenance Indication Adult patients with untreated advanced follicular lymphoma with Follicular Lymphoma International Prognostic Index (FLIPI) score of 2 or above. (NICE TA513)
More informationBreast Pathway Group Epirubicin & Cyclophosphamide x 4 followed by Carboplatin & Paclitaxel x 4 for Early Breast Cancer
Breast Pathway Group Epirubicin & Cyclophosphamide x 4 followed by Carboplatin & Paclitaxel x 4 for Early Breast Cancer Indication: Neoadjuvant therapy for patients with BRCA1/2 mutations EC Regimen details:
More informationBEACOPP-14/ BEACOPP- Escalated
BEACOPP-14/ BEACOPP- Escalated INDICATION Early Stage Classical Hodgkin Lymphoma with positive interim PET-CT (Deauville 3 or more) Advanced Classical Hodgkin lymphoma This protocol should normally be
More informationR-FC for Chronic Lymphocytic Leukaemia LKWOS-005/01
West of Scotland Cancer Network Chemotherapy Protocol R-FC for Chronic Lymphocytic Leukaemia LKWOS-005/01 Indication B cell Chronic Lymphocytic Leukaemia First line therapy in patients under 70 years of
More information5-FU & Cisplatin + Cetuximab
5-FU & Cisplatin + Cetuximab Available for Routine Use in Not routinely commissioned, each case requires prior documented approval before offering & commencing therapy from either: a) the relevant PCT
More informationSAALT3W Sarcoma Dr. Meg Knowling. Protocol Code Tumour Group Contact Physician
BCCA Protocol Summary for Etoposide, Ifosfamide-Mesna (SAIME) Alternating with vincristine, DOXOrubicin and Cyclophosphamide (with or without Mesna)(SAVAC or SAVACM) with Filgrastim Support at a THREE
More informationStRs and CT doctors in haematology. September Folinic acid dose modified.
High dose Methotrexate and folinic acid rescue Full Title of Guideline: Author (include email and role): Division & Speciality: Clinical Guideline Review Date September 2018 GUIDELINE FOR THE USE OF HIGH
More informationBreast Pathway Group TC (Docetaxel / Cyclophosphamide) in Early Breast Cancer
Breast Pathway Group TC (Docetaxel / Cyclophosphamide) in Early Breast Cancer Indication: Neoadjuvant or adjuvant treatment for patients in whom anthracyclines are contraindicated or inappropriate Regimen
More informationCisplatin / Paclitaxel Gynaecological Cancer
Systemic Anti Cancer Treatment Protocol Cisplatin / Paclitaxel Gynaecological Cancer PROCTOCOL REF: MPHAGYNCIP (Version No: 1.0) Approved for use in: First line treatment for stage Ib-IV with minimal residual
More informationBEACOPP-14/ Escalated BEACOPP
BEACOPP-14/ Escalated BEACOPP Indication Advanced stage Hodgkin Lymphoma where escalated therapy is indicated. Early Stage Classical Hodgkin Lymphoma with positive interim PET-CT (Deauville 3 or more).
More informationCisplatin and Vinorelbine and radiotherapy (NSCLC)
Cisplatin and Vinorelbine and radiotherapy (NSCLC) Indication First-line chemotherapy for use with concomitant radical radiotherapy for early or locally advanced non-small cell carcinoma (NSCLC) ICD-10
More informationNetwork Chemotherapy Regimens
Thames Valley Network Chemotherapy Regimens Urological Cancer Network Chemotherapy Protocols Urological Cancer 1 Notes from the editor Thames Valley These protocols are available on the Network website
More informationCisplatin and Vinorelbine and radiotherapy (NSCLC)
Cisplatin and Vinorelbine and radiotherapy (NSCLC) Indication First-line chemotherapy for use with concomitant radical radiotherapy for early or locally advanced non-small cell carcinoma (NSCLC) ICD-10
More informationNCCP Chemotherapy Regimen
Dose Dense DOXOrubicin, Cyclophosphamide (AC 60/600) 14 day followed by PACLitaxel (175) 14 day and Trastuzumab Therapy (DD AC-TH) Note: There is an option for Dose Dense DOXOrubicin, cyclophosphamide
More informationCisplatin Doxorubicin Sarcoma
Systemic Anti Cancer Treatment Protocol Cisplatin Doxorubicin Sarcoma PROCEDURE REF: MPHACISDOX (Version No. _1.0) Approved for use in: Osteosarcoma Palliative / advanced disease Not suitable for PAM schedule
More informationTHE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST. Systemic Anti Cancer Treatment Protocol. EDP + mitotane
Systemic Anti Cancer Treatment Protocol EDP + mitotane PROCEDURE REF: MPHAHANEDP (Version No: 1.0) Approved for use in: Symptomatic treatment for advanced (unresectable, metastatic or relapsed) adrenocortical
More informationCisplatin + Etoposide IV / Oral therapy followed by Chemo-radiotherapy in Small Cell Carcinoma of the Cervix
Cisplatin + Etoposide IV / Oral therapy followed by Chemo-radiotherapy in Small Cell Carcinoma of the Cervix Indication: Neoadjuvant chemotherapy followed by Chemo-radiotherapy in Small Cell Carcinoma
More informationR-CODOX-M Therapy (Patients greater than 65 years)
R-CODOX-M Therapy (Patients greater than 65 years) INDICATIONS FOR USE: Regimen Code 00403a *Reimbursement Indicator INDICATION ICD10 Treatment of Burkitt Lymphoma in patients aged greater than 65 C83
More information(primary CNS lymphoma)
(primary CNS lymphoma) INDICATION CNS Lymphoma TREATMENT INTENT Curative PRE-ASSESSMENT 1. Ensure histology is confirmed and documented in the notes. Although it is sometimes difficult to obtain tissue
More information