Pharmaceutical pathology
|
|
- Eugene Harrison
- 5 years ago
- Views:
Transcription
1 Pharmaceutical pathology Livia Vida Necrosis, types, examples. Apoptosis. 2. Adaptations I. Degeneration, atrophy. 3. Adaptations II. Hypertrophy, hyperplasia. 4. Pigments. Calcification. 5. Inflammation I. Acute inflammation. 6. Inflammation II. Chronic inflammation. 7. Circulation I. Thrombosis, embolisation, heart failure, shock. 8. Circulation II. Hypertension. Atherosclerosis. 9. Circulation III. Bleeding diatheses. Oedema, congestion. 10. Immunology I. Immune deficiencies. Hypersensitive reactions. 11. Immunology II. Autoimmunity. Transplantation immunity. 12. Infectology. 13. Oncology I. Nomenclature. Caracteristics of neoplasms. 14. Oncology II. Molecular basis of cancer. Autoimmunity Autoimmune diseases are caused by an immune reaction against self-antigens. They mayinvolve a single organ or be multisystemic. How does autoimmunity develop? Failure of peripheral tolerance Release of sequestered antigens Genetic predisposition may take several forms. Infections by viruses and other microbes may cause autoimmunity because of cross-reactivity. 1
2 SYSTEMIC LUPUS ERYTHEMATOSUS Lupus usually manifests as arthritis, skin changes, kidney damage, inflamed serosal membranes, fever, and mental changes. Most lupus victims look healthy, but they are very sick. Lupus is mostly a disease of young women. At least one woman in 1000 in the US and worldwide has overt lupus. Lupus is a disease of many autoantibodies directed against antigens that are common to most or all cells. Most lupus patients make antibodies against their own DNA. Lupus patients make many other weird antibodies. For example, they tend to develop false-positive syphilis tests. 2
3 SLE Blood vessels: Lupus vasculitis typically involves the small arteries and arterioles. Type III immune complex injury is usually implicated. When acute vasculitis is bad, plasma proteins that have gelled in the walls are called "fibrinoid". If the walls are dead, "fibrinoidnecrosis" is said to be present. More chronic vasculitis leads to fibrosis and narrowing of vessels. Kidney: The glomerulus traps antigens or pre-formed immune complexes as the strainer does in a sink. Several different glomerular syndromes can result. Skin: Patients must avoid sunlight. The famous "butterfly rash" ("acute cutaneous lupus") results from sunlight on the malar area of the face. SLE Joints: Arthritis (inflammation of joint tissues) is common in lupus. It resembles rheumatoid arthritis, though it is seldom mutilating. It is probably due to typeiii immune injury. The histology is acute and chronic synovitis. Heart: The best-known and most typical change is "nonbacterial verrucous endocarditis" (verrucous means warty), also called "Libman- Sacks endocarditis". 3
4 SLE Blood: Patients with lupus have increased total serum gamma globulins("polyclonal gammopathy"; a lab test result). Antibodiesagainstredcells, neutrophils, and platelets can cause the corresponding cytopenias. Patients with"lupus anticoagulant tend to have bleedings and thromboses. Lungs: Only a few patients get pulmonary lesions directly attributable to lupus. 4
5 Rheumatoid arthritis - RA Most patients with arthritis do not know which type they have.yet joint problems are the #1 recognized cause of occupational disability. RA is a common, usually chronic, systemic, dread inflammatory disease. Its outstanding feature is progressive, symmetrical synovitis, with pain and morning stiffness, and which may lead to deformity and destruction of the joints. An acute and chronic inflammatory synovitis leads to proliferation of a vascular connective tissue in the synovium("pannus"). You won't see pus. On arthroscopy, pannus looks like a sea anemone. Pannus spreads over and erodes the articular cartilage and even bone leading to fibrosis of the joint. RA RHEUMATOID FACTOR, present in most RA patients, is polyclonal antibody against the Fc portion of IgG. When present, the patient is said to be "seropositive"; otherwise, "seronegative." Its presence means the disease is more likely to be familial, there is more likely to be vasculitis, there are more likely to be rheumatoid nodules, and there is more likely to be eye involvement. 5
6 RHEUMATOID NODULES occur in maybe 20% of patients with rheumatoid arthritis. These consist of an acellular center of eosinophilic material ("fibrinoid", as before a mix of plasma proteins) surrounded by palisaded histiocytes and other cells. They may occur nearly anywhere; most often about extensor surfaces, sometimes the pericardium, aortic valve (thankfully rare), lung parenchyma. fibrinoid histiocytes RA Small joints are most often affected, especially the proximal interphalangeal joints, metacarpophalangeal joints (ulnar deviation), wrists, knees, ankles. Tendons may rupture, especially those that extend the last two fingers. Whatever the cause, central to today's thinking about rheumatoid arthritis is the understanding that the irreversible destruction of the joints begins with the first symptoms, and is cumulative and progressive. Hence the emphasis on diseasemodifying medications (methotrexate, many others from various classes) early-on, rather than just antiinflammatories. 6
7 7
8 TRANSPLANT REJECTION HYPERACUTE REJECTION happens when the patient gets a allograft and already has (or almost immediately makes) antibodies against it. There is a visible pattern of typeiii immune injury; typeii has also occurred. At removal of the organ, the pathologist will see a vasculitis, lots of neutrophils, complement deposition, and probably little thrombi wherever the endothelial cells got killed. ACUTE CELLULAR REJECTION, which may happen months or years after surgery, is mediated by T-cells. In the kidney (where this is best known) we look for "tubulitis" (lymphocytes in-between tubule cells), and "endotheliitis" (lymphocytes under the endothelium). ACUTE HUMORAL REJECTION, which also can begin months or years after transplantation, is caused by antibodies, with both typeii and typeiii injury. Of course the blood vessel intima take the most severe injury, and we see edema, fibroblast proliferation. We also look for C4d in the capillaries. Making the distinction from acute cellular rejection is very important, of course, because they're treated differently. CHRONIC REJECTION is still rather mysterious, and is usual in old allografts. Mostly you will see fibrosis of the organ and dense fibrous narrowing of the arterial lumens mostly by concentric proliferation of the intima. GRAFT VS. HOST DISEASE ("GVH") Whenbonemarrow(ormuchless often, some other organ containing T- cells) is transplanted into an immunedisabled patient, T-cells in the graft attack the"foreign" histo-compatibility antigens of the recipient. Acutegraftvs. hostdiseasemayoccur days following a transplant, even if HLA antigens appear identical. It involves primarily the skin(exfoliative dermatitis), gut(diarrhea, malabsorption, bloodydiarrhea), and liver(biliaryepithelium jaundice). 8
Types of osteoarthritis
ARTHRITIS Osteoarthritis is a degenerative joint disease is the most common joint disorder. It is a frequent part of aging and is an important cause of physical disability in persons older than 65 years
More informationAOS 3: Rheumatoid Arthritis
AOS 3: Rheumatoid Arthritis Arthritis (General) = inflamed joint - NOT a single disease: covers >100 types - Involves disability + decreased quality of life o Can also occur in young people (not just the
More informationIMMUNE DISORDER. Reference:-Pathophysiology: A 2-in-1 Reference for Nurses. Philadelphia, PA, USA: LWW (PE), 2004.
IMMUNE DISORDER Reference:-Pathophysiology: A 2-in-1 Reference for Nurses. Philadelphia, PA, USA: LWW (PE), 2004. Immune system disorders Hypersensitivity is an exaggerated or inappropriate response that
More informationPatient #1. Rheumatoid Arthritis. Rheumatoid Arthritis. 45 y/o female Morning stiffness in her joints >1 hour
Patient #1 Rheumatoid Arthritis Essentials For The Family Medicine Physician 45 y/o female Morning stiffness in her joints >1 hour Hands, Wrists, Knees, Ankles, Feet Polyarticular, symmetrical swelling
More informationMOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism
MOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism SCHMAIEL SHIRDEL CONTENT 2 Introduction Autoimmune diseases Classification Involved components Autoimmune
More informationHistopathology: Vascular pathology
Histopathology: Vascular pathology These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need to learn about these
More informationImmunology. Lecture- 8
Immunology Lecture- 8 Immunological Disorders Immunodeficiency Autoimmune Disease Hypersensitivities Immunodeficiency 1. Immunodeficiency --> abnormal production or function of immune cells, phagocytes,
More informationAutoimmunity & Transplantation. Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel:
Autoimmunity & Transplantation Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel: 4677363 aalshamsan@ksu.edu.sa Learning Objectives By the end of this lecture you will be able to: 1 Recognize
More informationDr Ian Roberts Oxford
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing renal failure Highlight diagnostic pitfalls. Crescentic GN: renal
More information10/25/2018. Autoimmunity and how to treat it. Disclosure. Why do we get autoimmunity? James Verbsky MD/PhD Pediatric Rheumatology/Immunology
Autoimmunity and how to treat it James Verbsky MD/PhD Pediatric Rheumatology/Immunology Disclosure None I will mention drug names and some brand names but I have no financial interest or any other ties
More informationSystemic Lupus Erythematosus
A Patient s Guide to Systemic Lupus Erythematosus 2 kidneys. These changes make it impossible for the kidneys to function normally. The inflammation of SLE can be seen in the lining, covering, and muscles
More informationHow the Innate Immune System Profiles Pathogens
How the Innate Immune System Profiles Pathogens Receptors on macrophages, neutrophils, dendritic cells for bacteria and viruses Broad specificity - Two main groups of bacteria: gram positive, gram-negative
More informationWhat will we discuss today?
Autoimmune diseases What will we discuss today? Introduction to autoimmune diseases Some examples Introduction to autoimmune diseases Chronic Sometimes relapsing Progressive damage Epitope spreading more
More informationSelf-tolerance. Lack of immune responsiveness to an individual s own tissue antigens. Central Tolerance. Peripheral tolerance
Autoimmunity Self-tolerance Lack of immune responsiveness to an individual s own tissue antigens Central Tolerance Peripheral tolerance Factors Regulating Immune Response Antigen availability Properties
More informationRheumatoid Arthritis. Marge Beckman FALU, FLMI Vice President RGA Underwriting Quarterly Underwriting Meeting March 24, 2011
Rheumatoid Arthritis Marge Beckman FALU, FLMI Vice President RGA Underwriting Quarterly Underwriting Meeting March 24, 2011 The security of experience. The power of innovation. www.rgare.com Case Study
More informationWRITTEN BY: Thaer Al-qatish & Sarah Awaisheh
WRITTEN BY: Thaer Al-qatish & Sarah Awaisheh Not all informations in the slides are included in this sheet so please study the slides. 3 kinds of Intracardiac infections: -endocarditis(inflammation of
More informationDr Rodney Itaki Lecturer Anatomical Pathology Discipline. University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology
Vasculitis Dr Rodney Itaki Lecturer Anatomical Pathology Discipline University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology Disease Spectrum Hypersensitivity vasculitis/microscopic
More informationManagement of Rejection
Management of Rejection I have no disclosures Disclosures (relevant or otherwise) Deborah B Adey, MD Professor of Medicine University of California, San Francisco Kidney and Pancreas Transplant Center
More informationRenal Pathology- Transplantation. Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic
Renal Pathology- Transplantation Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic eva.honsova@ikem.cz Kidney has a limited number of tissue reactions by which the kidney
More information- Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ.
Immunology Lecture num. (21) Transplantation - Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ. Types of Graft (4 types): Auto Graft - From a person
More informationTransplantation. Immunology Unit College of Medicine King Saud University
Transplantation Immunology Unit College of Medicine King Saud University Objectives To understand the diversity among human leukocyte antigens (HLA) or major histocompatibility complex (MHC) To know the
More informationRheumatoid Arthritis. Manish Relan, MD FACP RhMSUS Arthritis & Rheumatology Care Center. Jacksonville, FL (904)
Rheumatoid Arthritis Manish Relan, MD FACP RhMSUS Arthritis & Rheumatology Care Center. Jacksonville, FL (904) 503-6999. 1 Disclosures Speaker Bureau: Abbvie 2 Objectives Better understand the pathophysiology
More informationGlomerular pathology in systemic disease
Glomerular pathology in systemic disease Lecture outline Lupus nephritis Diabetic nephropathy Glomerulonephritis Associated with Bacterial Endocarditis and Other Systemic Infections Henoch-Schonlein Purpura
More informationBiopsy Features of Kidney Allograft Rejection Banff B. Ivanyi, MD Department of Pathology, University of Szeged, Szeged, Hungary
Biopsy Features of Kidney Allograft Rejection Banff 2017 B. Ivanyi, MD Department of Pathology, University of Szeged, Szeged, Hungary Treatment of allograft dysfunction should rely on the biopsy findings
More informationHistopathology: Glomerulonephritis and other renal pathology
Histopathology: Glomerulonephritis and other renal pathology These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you
More informationEditing file. Color code: Important in red Extra in blue. Autoimmune Diseases
Editing file Color code: Important in red Extra in blue Autoimmune Diseases Objectives To know that the inflammatory processes in autoimmune diseases are mediated by hypersensitivity reactions (type II,
More informationCHRONIC INFLAMMATION
CHRONIC INFLAMMATION Chronic inflammation is an inflammatory response of prolonged duration often for months, years or even indefinitely. Its prolonged course is proved by persistence of the causative
More informationAUTOIMMUNITY CLINICAL CORRELATES
AUTOIMMUNITY CLINICAL CORRELATES Pamela E. Prete, MD, FACP, FACR Section Chief, Rheumatology VA Healthcare System, Long Beach, CA Professor of Medicine, Emeritus University of California, Irvine Colonel
More informationAUTOIMMUNITY TOLERANCE TO SELF
AUTOIMMUNITY CLINICAL CORRELATES Pamela E. Prete, MD, FACP, FACR Section Chief, Rheumatology VA Healthcare System, Long Beach, CA Professor of Medicine, Emeritus University of California, Irvine Colonel
More informationAUTOIMMUNE DISORDERS IN THE ACUTE SETTING
AUTOIMMUNE DISORDERS IN THE ACUTE SETTING Diagnosis and Treatment Goals Aimee Borazanci, MD BNI Neuroimmunology Objectives Give an update on the causes for admission, clinical features, and outcomes of
More informationThe Diagnosis of Lupus
The Diagnosis of Lupus LUPUSUK 2017 This information booklet has been produced by LUPUS UK 2017 LUPUS UK LUPUS UK is the registered national charity for people with systemic lupus erythematosus (SLE) and
More informationThe Rheumatoid Hand Deformities & Management. Dr. Anirudh Sharma Resident Department of Orthopedics
+ The Rheumatoid Hand Deformities & Management Dr. Anirudh Sharma Resident Department of Orthopedics + Why is Rheumatoid Arthritis important? + RA is a very debilitating disease median life expectancy
More informationHYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
More informationCase Presentation VASCULITIS. Case Presentation. Case Presentation. Vasculitis
Case Presentation VASCULITIS The patient is a 24 year old woman who presented to the emergency room with left-sided weakness. She was confused and complained of a severe headache. She was noted to have
More informationJuvenile Chronic Arthritis
Juvenile Chronic Arthritis Dr. Christa Visser MBChB MMed (Med Phys) Diploma Musculoskeletal Medicine (UK), Member Society of Orthopaedic Medicine (UK) Childhood Arthritis JCA/JIA/JRA Remember Acute rheumatic
More informationPulmonary Vascular Disease in Systemic Lupus Erythematosus
Pulmonary Vascular Disease in Systemic Lupus Erythematosus A. OLUSEGUN FAYEMI, M.D.* Department of Pathology, The Mount Sinai School of Medicine of the City University of New York, New York, New York 129
More informationEtiology: Pathogenesis Clinical manifestation Investigation Treatment Prognosis
Etiology: Pathogenesis Clinical manifestation Investigation Treatment Prognosis JIA is the most common rheumatic disease in childhood and a major cause of chronic disability. Etiology: Unknown, but may
More informationDr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Plan of attack: Diagnostic approach to the renal biopsy Differential diagnosis of the clinical syndromes of renal disease Microscopy Step
More informationLupus. Fast facts. What is lupus? What causes lupus? Who gets lupus?
Lupus Systemic lupus erythematosus, referred to as SLE or lupus, is sometimes called the "great imitator." Why? Because of its wide range of symptoms, people often confuse lupus with other health problems.
More informationType III Hypersensitivity. Immune Complex Mediated Reaction
Type III Hypersensitivity Immune Complex Mediated Reaction Type III: Immune Complex Mediated Reaction *When antibodies (Ig G or Ig M) and antigen coexist immune complexes are formed *Immune complexes are
More informationVASCULITIS. Case Presentation. Case Presentation
VASCULITIS Case Presentation The patient is a 24 year old woman who presented to the emergency room with left-sided weakness. She was confused and complained of a severe headache. She was noted to have
More informationHistopathology: Hypertension and diabetes in the kidney These presentations are to help you identify basic histopathological features.
Histopathology: Hypertension and diabetes in the kidney These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need
More informationRheumatoid arthritis
Rheumatoid arthritis 1 Definition Rheumatoid arthritis is one of the most common inflammatory disorders affecting the population worldwide. It is a systemic inflammatory disease which affects not only
More informationSystemic forms of stiffness
Systemic forms of stiffness ANNA LITWIC CONSULTANT RHEUMATOLOGIST SALISBURY DISTRICT HOSPITAL CLINICAL RESEARCH FELLOW MRC LIFECOURSE EPIDEMIOLOGY UNIT Overview Rheumatoid arthritis Know it when you see
More information. Autoimmune disease. Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology
. Autoimmune disease Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology, Paul Ehrich The term coined by the German immunologist paul Ehrich ( 1854-1915) To describe the bodys innate aversion to immunological
More informationHistopathology: Cell necrosis and cytoplasmic accumulations
Histopathology: Cell necrosis and cytoplasmic accumulations These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you
More informationAutoimmune diseases. SLIDE 3: Introduction to autoimmune diseases Chronic
SLIDE 3: Introduction to autoimmune diseases Chronic Autoimmune diseases Sometimes relapsing : and remitting. which means that they present as attacks Progressive damage Epitope spreading more and more
More informationHths 2231 Laboratory 7 Infection
Watch Movie: Meningitis Answer the movie questions on the worksheet. Complete activities 1-3. Activity #1: Go to the patho web page and click on activity 1. Click on Tutorials Click on Immunopathology
More informationOverview. Barriers help animals defend against many dangerous pathogens they encounter.
Immunity Overview Barriers help animals defend against many dangerous pathogens they encounter. The immune system recognizes foreign bodies and responds with the production of immune cells and proteins.
More informationAnaphylactic response in rabbit Part II
Anaphylactic response in rabbit Part II Introduction Four types of hypersensitivity reactions: Type I: allergy Type II: antibodies Type III: immune complex Type IV: T-cells Type I Hypersensitivity ALLERGY
More informationDISCLOSURE. Relevant relationships with commercial entities none. Potential for conflicts of interest within this presentation none
AUTOIMMUNITY DISCLOSURE Relevant relationships with commercial entities none Potential for conflicts of interest within this presentation none Steps taken to review and mitigate potential bias N/A MODULE
More informationMedical Immunology Dr. Hassan Abul Raghib Lecture 16
Medical Immunology Dr. Hassan Abul Raghib Lecture 16 Autoimmunity: Natural Auto-Antibodies: - Autoimmunity is not very uncommon; because there are auto-antibodies in all of us (natural auto-antibodies).
More informationPathophysiology of Cardiovascular System. Dr. Hemn Hassan Othman, PhD
Pathophysiology of Cardiovascular System Dr. Hemn Hassan Othman, PhD hemn.othman@univsul.edu.iq What is the circulatory system? The circulatory system carries blood and dissolved substances to and from
More informationRENAL HISTOPATHOLOGY
RENAL HISTOPATHOLOGY Peter McCue, M.D. Department of Pathology, Anatomy & Cell Biology Sidney Kimmel Medical College There are no conflicts of interest. 1 Goals and Objectives! Goals Provide introduction
More informationRECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT. J. H. Helderman,MD,FACP,FAST
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT J. H. Helderman,MD,FACP,FAST Vanderbilt University Medical Center Professor of Medicine, Pathology and Immunology Medical Director, Vanderbilt Transplant
More informationRequirements in the Development of an Autoimmune Disease Amino Acids in the Shared Epitope
+ T cell MHC/self-peptide MHC/Vβ Induction of + T H 1 mediated autoimmunity: A paradigm for the pathogenesis of rheumatoid arthritis, multiple sclerosis and type I diabetes APC Activated autoreactive +
More informationNOTES: CH 43, part 2 Immunity; Immune Disruptions ( )
NOTES: CH 43, part 2 Immunity; Immune Disruptions (43.3-43.4) Activated B & T Lymphocytes produce: CELL-MEDIATED IMMUNE RESPONSE: involves specialized T cells destroying infected host cells HUMORAL IMMUNE
More informationArthritis & Rheumatology Clinics of Kansas PATIENT EDUCATION SYSTEMIC LUPUS ERYTHEMATOSUS
Arthritis & Rheumatology Clinics of Kansas PATIENT EDUCATION SYSTEMIC LUPUS ERYTHEMATOSUS Introduction: There is perhaps no rheumatic disease that evokes so much fear and confusion among both patients
More informationInterpretation of Renal Transplant Biopsy. Arthur H. Cohen Wake Forest University School of Medicine Winston-Salem, North Carolina USA
Interpretation of Renal Transplant Biopsy Arthur H. Cohen Wake Forest University School of Medicine Winston-Salem, North Carolina USA Renal Transplant Biopsies Tissue Processing Ideal world process as
More informationFoundations in Microbiology Seventh Edition
Lecture PowerPoint to accompany Foundations in Microbiology Seventh Edition Talaro Chapter 16 To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn
More informationRheumatoid Arthritis
Rheumatoid Arthritis What is rheumatoid arthritis? Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Rheumatoid arthritis can also cause inflammation of
More information3.Autoimmunity. a. Self-recognition of all body components. a. Auto-antibody directed against a self antigen.
3.Autoimmunity I. Introduction A. Introduction 1. Normal individuals do not produce destructive immune responses to their own tissues due to immune tolerance. a. Self-recognition of all body components.
More informationINFLAMMATION. 5. Which are the main phases of inflammation in their "sequence": 1. Initiation, promotion, progression.
INFLAMMATION 1. What is inflammation: 1. Selective anti-infective pathological reaction. 2. Pathological process, typical for vascularized tissues. 3. Self-sustained pathological condition. 4. Disease
More informationCase reports CASE 1. A 67-year-old white man had back pain since the age. our clinic several years later with progressive symptoms.
Annals of the Rheumatic Diseases, 1982, 41, 574-578 Late-onset peripheral joint disease in ankylosing spondylitis MARC D. COHEN AND WILLIAM W. GINSBURG From the Division ofrheumatology and Internal Medicine,
More informationand immune cells Dr Leanne Gardner Dr Carol Pridgeon Imperial College London
and immune cells Dr Leanne Gardner Dr Carol Pridgeon Imperial College London What causes this? http://www.bioan.dk/projekter/methicillin _Resistente_S.aureus.htm www.thesahara.net/ feet_foot_nail_care.htm
More informationWhat are bacteria? Microbes are microscopic(bacteria, viruses, prions, & some fungi etc.) How do the sizes of our cells, bacteria and viruses compare?
7.1 Microbes, pathogens and you Chp. 7 Lymphatic System & Immunity The interaction between microbes and humans? Microbes are very abundant in the environment and as well as in and on our bodies GOOD: We
More informationHypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host.
Hypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host. Hypersensitivity vs. allergy Hypersensitivity reactions require a pre-sensitized
More informationYear 2004 Paper one: Questions supplied by Megan
QUESTION 53 Endothelial cell pathology on renal biopsy is most characteristic of which one of the following diagnoses? A. Pre-eclampsia B. Haemolytic uraemic syndrome C. Lupus nephritis D. Immunoglobulin
More informationGeneral Pathology Theory Syllabus for II B.D.S.
General Pathology Theory Syllabus for II B.D.S. Sr. No. Topic (Must Know) (Desirable to know) 1.Introduction to Pathology - Different sections in pathology - The Cell in health - Normal cell structure
More informationMyositis and Your Lungs
Myositis and Your Lungs 2013 TMA Annual Patient Meeting Louisville, Kentucky Chester V. Oddis, MD University of Pittsburgh Director, Myositis Center Myositis Heterogeneous group of autoimmune syndromes
More informationUnderstanding Rheumatoid Arthritis
Understanding Rheumatoid Arthritis Understanding Rheumatoid Arthritis What Is Rheumatoid Arthritis? 1,2 Rheumatoid arthritis (RA) is a chronic autoimmune disease. It causes joints to swell and can result
More informationImmune Responses KEY CONCEPT The immune system has many responses to pathogens and foreign cells.
SECTION 31.3 Immune Responses KEY CONCEPT The immune system has many responses to pathogens and foreign cells. Student text pages 950 954 SC.912.L.14.52 Many body systems work to produce nonspecific responses.
More informationAll animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity
1 2 3 4 5 6 7 8 9 The Immune System All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity Figure 43.2 In innate immunity, recognition and
More informationTest Name Results Units Bio. Ref. Interval
135091662 Age 45 Years Gender Male 29/8/2017 120000AM 29/8/2017 100215AM 29/8/2017 110825AM Ref By Final RHEUMATOID AUTOIMMUNE COMREHENSIVE ANEL ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF), SERUM ----- 20-60
More informationAMR in Liver Transplantation: Incidence
AMR in Liver Transplantation: Incidence Primary AMR 1/3 to 1/2 of ABO-incompatible transplants Uncommon with ABO-compatible transplant Secondary AMR Unknown incidence: rarely tested Why is AMR uncommon
More informationDiseases of cardiavascular system
Diseases of cardiavascular system Ph.D Wei Zhang ( 张伟 ) Associate Professor Institute of Pathology & Forensic Medicine, Zhejiang University, School of Medicine zwei72@zju.edu.cn Hypertension Introduction
More informationThe Immune System: The Mind Body Connection. Presented by Margaret Kemeny, Ph.D. Department of Psychiatry, University of California, San Francisco
The Immune System: The Mind Body Connection Presented by Margaret Kemeny, Ph.D. Department of Psychiatry, University of California, San Francisco Psychoneuroimmunology Investigation of the bidirectional
More informationRheumatic heart disease
Rheumatic heart disease What will we discuss today? Etiology and epidemiology of rheumatic heart disease Pathogenesis of rheumatic heart disease Morphological changes in rheumatic heart disease Clinical
More informationRheumatoid Arthritis
Rheumatoid Arthritis Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Autoimmune diseases are illnesses that occur when the body's tissues are mistakenly
More informationA clinical syndrome, composed mainly of:
Nephritic syndrome We will discuss: 1)Nephritic syndrome: -Acute postinfectious (poststreptococcal) GN -IgA nephropathy -Hereditary nephritis 2)Rapidly progressive GN (RPGN) A clinical syndrome, composed
More informationElements for a Public Summary
VI.2 Elements for a Public Summary VI.2.1 Overview of disease epidemiology Osteoarthritis Osteoarthritis is the most common type of joint disease. It represents a group of conditions that result in changes
More informationChapter 16 Lymphatic System and Immunity. Lymphatic Pathways. Lymphatic Capillaries. network of vessels that assist in circulating fluids
Chapter 16 Lymphatic System and Immunity network of vessels that assist in circulating fluids closely associated with the cardiovascular system transports excess fluid away from interstitial spaces transports
More informationVasculitis local: systemic
Vasculitis Inflammation of the vessel wall. Signs and symptoms: 1- local: according to the involved tissue 2- systemic:(fever, myalgia, arthralgias, and malaise) Pathogenesis 1- immune-mediated 2- infectious
More informationSome renal vascular disorders
Some renal vascular disorders Introduction Nearly all diseases of the kidney involve the renal blood vessels secondarily We will discuss: -Hypertension (arterionephrosclerosis in benign HTN & hyperplastic
More informationReporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation
Reporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation Marcelo C. Pasquini, MD, MSc HVD05_1.ppt Outline Review of autoimmune diseases (AID). Role of transplantation for AID Data collection:
More informationBSD Self Assessment Workshop 7 th July 2013 CASE 27 RAC6123
BSD Self Assessment Workshop 7 th July 2013 CASE 27 RAC6123 M55. 4/7 tender lesions on knee, legs and arms. Also iritis/ weight loss/headache, synovitis.?vasculitis. Sarcoidosis. Biopsy from left elbow
More informationExtracellular degeneration
Extracellular degeneration By Dr. Hemn Hassan Othman PhD, Pathology Fall 2016 1/17/2017 1 Extracellular Degenerations I / Hyaline Degeneration (Hyalinization): The ward hyaline is derived from the Latin
More informationAmino acid sequences in the β chain HLA- DRB*0401 molecules dictate susceptibility to RA Amino Acids in the Shared Epitope
MHC/self-peptide MHC/Vβ TCR Vβx + Vβx T cell Induction of + TH1 mediated autoimmunity: A paradigm for the pathogenesis of rheumatoid arthritis, multiple sclerosis and APC type I diabetes TCR Vβx Activated
More informationVascular pathology. dr. Budiana Tanurahardja.,SpPA
Vascular pathology dr. Budiana Tanurahardja.,SpPA DEPARTMENT of ANATOMIC PATHOLOGY FACULTY of MEDICINE UNIVERSITY of INDONESIA Center of Anatomic Pathology Studies Vascular Pathology Normal blood vessels.
More informationArticular disease of the hand - the target joint approach
Articular disease of the hand - the target joint approach Poster No.: C-1817 Congress: ECR 2016 Type: Educational Exhibit Authors: R. R. Domingues Madaleno 1, A. P. Pissarra 1, I. Abreu 2, A. Canelas 1,
More informationThe Lymphatic System and Body Defenses
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College The Lymphatic System and Body Defenses 12PART B Adaptive Defense System: Third Line of Defense Immune
More informationHENOCH SCHÖNLEIN PURPURA (VASCULAR PURPURA, ANAPHYLACTOID PURPURA) IN CHILDREN Single choice tests (SC)
HENOCH HÖNLEIN PURPURA (VAULAR PURPURA, ANAPHYLACTOID PURPURA) IN CHILDREN Single choice tests () 1. Choose the type of bleeding characteristic for the Henoch Schönlein purpura (vascular purpura, anaphylactoid
More informationFourth Practical Pathology. Circulatory disturbances
Fourth Practical Pathology Circulatory disturbances 12.12.2018 1 Organ: Lung (40X, low power) 1) The blood capillaries within the alveolar septa are engorged with blood 2) Pinkish proteinaceous fluid,
More informationRHEUMATOLOGY OVERVIEW. Carmelita J. Colbert, MD Assistant Professor of Medicine Division of Rheumatology Loyola University Medical Center
RHEUMATOLOGY OVERVIEW Carmelita J. Colbert, MD Assistant Professor of Medicine Division of Rheumatology Loyola University Medical Center What is Rheumatology? Medical science devoted to the rheumatic diseases
More informationDisruptions in the Immune
Disruptions in the Immune System Bởi: OpenStaxCollege A functioning immune system is essential for survival, but even the sophisticated cellular and molecular defenses of the mammalian immune response
More informationMedical Immunology Practice Questions-2016 Autoimmunity + Case Studies
Medical Immunology Practice Questions-2016 Autoimmunity + Case Studies Directions: Each of the numbered items or incomplete statements in this section is followed by answers or by completions of the statement.
More informationChapter 13 Lecture Outline
Chapter 13 Lecture Outline See separate PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction
More informationnumber Done by Corrected by Doctor Mousa Al-Abbadi
number 11 Done by Husam Abu-Awad Corrected by Muhammad Tarabieh Doctor Mousa Al-Abbadi The possible outcomes of an acute inflammation are the following: 1- A complete resolution in which the tissue returns
More informationCrescentic Glomerulonephritis (RPGN)
Crescentic Glomerulonephritis (RPGN) Background Rapidly progressive glomerulonephritis (RPGN) is defined as any glomerular disease characterized by extensive crescents (usually >50%) as the principal histologic
More informationDEGENERATION NECROSIS AND INFILTRATION
DEGENERATION NECROSIS AND INFILTRATION Cellular Degenerations and Infiltrations 1. Cloudy swelling and hydropic degeneration Cloudy swelling and hydropic degeneration occur when the regulatory mechanisms
More information