Comparison of representative topical corticosteroid preparations (classified according to the US system)

Transcription

1 Comparison of representative topical corticosteroid preparations (classified according to the US system) Potency group* Corticosteroid Vehicle type/form Trade names (United States) Available strength(s), percent (except as noted) Super-high potency (group ) di, augmented Clobetasol Ointment, optimized Diprolene Lotion Diprolene Gel Diprolene Ointment Temovate Temovate, emollient base Temovate E Gel Temovate Lotion Clobex Foam aerosol Olux-E Foam aerosol (scalp) Olux Shampoo Clobex Solution (scalp) Temovate, Cormax Spray aerosol Clobex Diflucortolone (not available in United States) Ointment, oily cream Nerisone Forte (United Kingdom, others) 0.3 Fluocinonide Vanos Flurandrenolide Tape (roll) Cordran 4 mcg/cm 2 Halobetasol Ointment Ultravate Ultravate High potency (group 2) Lotion Ultravate Amcinonide Ointment Cyclocort, Amcort di Ointment Diprosone, augmented formulation (AF) Diprolene AF Clobetasol Impoyz Desoximetasone Ointment Topicort 0.25 Topicort 0.25 Spray Topicort 0.25 Gel Topicort

2 Diflorasone diacetate Ointment ApexiCon, Florone, emollient ApexiCon E Fluocinonide Ointment Lidex Gel Lidex anhydrous Lidex Solution Lidex Halcinonide Ointment Halog High potency (group 3) Halog Amcinonide Cyclocort, Amcort Lotion Amcort di, hydrophilic emollient Diprosone Ointment Valisone Foam Luxiq 2 Desoximetasone Topicort LP Diflorasone diacetate Florone Diflucortolone (not available in United States) Fluocinonide, oily cream, ointment aqueous emollient Nerisone (Canada, United Kingdom, others) Lidex-E Fluticasone Ointment Cutivate Mometasone furoate Ointment Elocon Medium potency (group 4) di Ointment Kenalog 0.5 Triderm, Aristocort HP 0.5 Spray Sernivo Clocortolone pivalate Cloderm Fluocinolone Ointment Synalar Flurandrenolide Ointment Cordran Ointment Westcort 0.2 Mometasone furoate Elocon Lotion Elocon Solution Elocon Kenalog Ointment Kenalog

3 Lower-mid potency (group 5) di Aerosol spray Kenalog 0.2 mg per 2 second spray Lotion Diprosone Beta-Val, Valisone Desonide Ointment DesOwen, Tridesilon Fluocinolone Gel Desonate Synalar Flurandrenolide Cordran Lotion Cordran Fluticasone butyrate Cutivate Lotion Cutivate Ointment Locoid Locoid, Locoid Lipocream Lotion, spray Cortizone 0 maximum Lotion Locoid Solution Locoid probutate Pandel Westcort 0.2 Prednicarbate, emollient Dermatop Ointment Dermatop Low potency (group 6) Alclometasone di Lotion Kenalog Ointment Kenalog Ointment Aclovate Aclovate Lotion Beta-Val, Valisone Desonide DesOwen, Tridesilon Lotion DesOwen, LoKara Fluocinolone Foam Verdeso Synalar Solution Synalar Shampoo Capex Oil (scalp) Derma-Smoothe/FS Scalp

4 Least potent (group 7) (base, 2%) Oil (body) Derma-Smoothe/FS Body Kenalog, Aristocort Lotion Kenalog Ointment Hytone 2.5 Hytone, Nutracort 2.5 Lotion Hytone, Ala Scalp, Scalacort 2.5 or 2 Solution Texacort 2.5 (base, <2%) Ointment Cortaid, Hytone, Nutracort Cortaid, Hytone, Synacort Lotion Aquanil HC, Sarnol- HC, Cortizone 0 Spray Cortaid Solution Cortaid, Noble, Scalp relief Ointment Cortaid 0.5 Cortaid 0.5 acetate with pramoxine % combination Ointment Pramosone or 2.5 Lotion Pramosone, Analpram-HC Pramosone, Analpram-HC or 2.5 or 2.5 Aerosol foam Epifoam US: United States. * Listed by potency according to the US classification system: group is the most potent, group 7 is the least potent. Other countries use a different classification system with only four or five groups. Inactive United States trade name for specific product; brand may be available outside United States. 48% refined peanut oil. Data from:. Lexicomp Online. Copyright Lexicomp, Inc. All Rights Reserved. 2. Tadicherla S, Ross K, Shenefelt D. Topical corticosteroids in dermatology. Journal of Drugs in Dermatology 2009; 2: U.S. Food & Drug Administration Approved Drug Products with Therapeutic Equivalence (Orange Book). Available at: (Accessed on June 8, 207). Graphic Version 46.0

5 GRAPHICS Topical antifungal agents Azoles Drug Dose How supplied* Clotrimazole Twice per day % Ointment % Solution % Econazole Once per day (twice per day for candidiasis) % Foam % Efinaconazole Once per day Solution 0% Ketoconazole Once per day (shampoo is usually one use) 2% Shampoo 2% (% shampoo is available overthe-counter) Gel 2% Foam 2% Luliconazole Once per day % Miconazole Twice per day 2% Ointment 2% Solution 2% Lotion 2% Powder 2% Aerosol solution 2% Aerosol powder 2% Oxiconazole Once to twice per day % Lotion % Sertaconazole Twice per day 2% Sulconazole Once or twice per day % Allylamines Solution % Naftifine Once per day (cream), twice per day (gel) % 2% Gel % Gel 2% Terbinafine Once to twice per day % Benzylamine Gel % Spray solution % Butenafine Once per day (twice per day for tinea pedis) % Polyene: Treats Candida infections only Nystatin Two to three times per day 00,000 units/gram

6 Other Ointment 00,000 units/gram Powder 00,000 units/gram Ciclopirox Twice per day 0.77% Gel 0.77% Suspension 0.77% Shampoo % Solution 8% Tolnaftate Twice per day % Powder % Aerosol: Liquid % Powder % Solution % * Preparations available in United States and some other countries. Azoles have activity against dermatophytes, tinea versicolor, and Candida. Sulconazole, oxiconazole, and luliconazole may be less effective for Candida infection than other azoles. Available in over-the-counter (nonprescription) preparations in the United States and some other countries. Indicated for onychomycosis. Can treat Candida in addition to dermatophytes and tinea versicolor but may be less effective than azoles and ciclopirox for Candida infection. Treats dermatophytes, tinea versicolor, and Candida. Does not treat Candida; less effective than other options for dermatophytes. Prepared with data from: US Food & Drug Administration (FDA) approved product information. US National Library of Medicine. (Available online at: Graphic 7648 Version.0