International Journal of Innovative Pharmaceutical Sciences and Research
|
|
- Thomas Fox
- 5 years ago
- Views:
Transcription
1 International Journal of Innovative Pharmaceutical Sciences and Research FORMULATION AND EVALUATION OF MODIFIED REALEASE CAPSULES OF BUDESONIDE 1 K.Veera Kumari*, 2 Dr. Appa Rao, 3 Dr.Shaik.Harun Rasheed 1,2 Department of Pharmaceutics, Victoria College of Pharmacy, Nallapadu, Guntur, A.P, INDIA. 3 Department of Pharmaceutics, DCRM College of Pharmacy, Inkollu, Prakasam, A.P, INDIA. Abstract Controlled release formulation of Budesonide modified release capsules was formulated by suspension layering by matrix layer formulation method using aqua coat ECD, acetyl tri butyl citrate, eudragit L30D55 and triethyl citrate. Infrared spectra of the drug along with the polymers reveal that there is no interaction between drug and polymers. Preformulation studies were done initially and found to be within the limits. The study was carried out by solution/suspension matrix layering, first drug and polymer solutions were mixed, coating was done on the sugar spheres and further enteric coating was done on the polymer matrix coated pellets. Different trails were conducted with various percentages of polymers and other excipients in the first (drug loading) and second stage (during enteric coating) and the formulation was finally optimized based on the Cumulative % drug release. The evaluation test results are found to be within pharmacopieal specifications. The in-vitro dissolution tests were performed for all trails. Dissolution profile of formulation F9 matched with the innovator s product and was found to be satisfactory. Stability studies both accelerated and long term stability studies were conducted for two months. During this study, the formulation F9 was found to be stable and no differences in the assay, moisture content and release characteristics were noticed. Keyword: Budesonide, Controlled release formulation, modified release capsules, enteric coating, Aqua coat ECD, Eudragit L30D55 Corresponding Author: K.Veera Kumari Department of Pharmaceutics Victoria College of Pharmacy Nallapadu, Guntur, A.P, INDIA veerakumarikambhampati@gmail.com Mobile: Available online: September Issue 2209
2 INTRODUCTION Pharmaceutical Oral solid dosage forms have been used widely for decades mainly due to their convenience of administration and their suitability for delivery of drugs for systemic effects The salient aspect of conventional methods of drug delivery including tablets, capsules, and liquids is the fluctuation in concentration between dosages [1]. Some drug fluctuations cause no problems, but some drugs that cause toxic reaction when administered above a narrow therapeutic concentration range, such a variation can cause considerable side effects. Thus ideal goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration. i.e., the drug delivery system should deliver the drug at a rate dictated by the needs of the body over a specified period of treatment. The overall action of a drug molecule is dependent on its inherent therapeutic activity and the efficiency with which it is delivered to the site of action. An increasing appreciation of the latter has led to the evolution and development of novel drug delivery systems (NDDS), aimed at performance enhancement of potential drug molecules. Novel drug delivery systems (NDDS) are the key area of pharmaceutical research and development. The reason is relatively low development cost and time required for introducing a NDDS ($20-50 million and 3-4 years, respectively) as compared to new chemical entity (approximately $500 million and years, respectively) [2]. The focus in NDDS includes design of NDDS for new drugs on one hand and on the other NDDS for established drugs to enhance commercial viability. Oral route remains one of the most natural routes of drug administration and has seen remarkable accomplishments in the last couple of decades towards optimization of oral delivery of drug molecules. Oral ingestion is one of the oldest and most extensively used routes of drug administration, providing a convenient method of effectively achieving both local and systemic effects [3]. Available online: September Issue 2210
3 Modified release drug delivery system: The oral route of drug delivery is typically considered the preferred and most patient convenient means of drug administration. Consequently, much effort is directed during drug discovery to identify orally active candidates that will provide reproducible and effective plasma concentrations in vivo. The reality is that many compounds are either incompletely or ineffectively absorbed after oral administration (i.e. bioavailability is an issue), or that the required dosing frequency is too short to enable once or twice daily administration (ie. Pharmacokinetic half-life is an issue) [5]. Modified release formulation technologies offer an effective means to optimize the bioavailability and resulting blood concentration time profiles of drugs that otherwise suffer from limitations. Modified release refers to controlled, delayed and extended release systems for oral administration as well as oral delivery system s designed specifically to modify the release of poorly water soluble drugs [4]. Sustained release systems include any drug delivery system that achieves slow release of drug over an extended period of time. If the system can provide some control, whether this is of a temporal or spatial nature, or both of drug release in the body, or in other words, the system is successful maintaining constant drug levels in the target cells or tissues, it is considered a controlled release system [6]. Potential advantages of controlled drug therapy All controlled release products share the common goal of improving drug therapy over that achieved with their non-controlled counter parts. This improvement in drug therapy is represented by several potential advantages, which include: Avoid patient compliance problems. Reduction in frequency of dosing. Employ minimum total drug. Minimize or eliminate local side effects. Minimize or eliminate systemic side effects. Cure or control condition more promptly. Available online: September Issue 2211
4 Reduce fluctuations in drug level. Improve bioavailability of some drugs. Minimize drug accumulation with chronic dosing. Improve efficacy in treatment. Make use of special effects e.g. sustained release aspirin for morning relief of arthritis by dosing before bedtime. Mups for CR Systems Oral modified drug delivery systems can be classified into two broad groups: 1. Single Unit dosage forms. 2. Multiple unit particles. Multiple unit particles (MUPS), such as granules, pellets, or mini tablets The concept of MUPS was initially introduced in 1950s. The production of MUPS is a common strategy to control the release of drug as shown by the reproducibility of the release profiles when compared to the ones obtained with SUDFS. The concept of MUPS is characterized by the fact that the dose is administered as a number of sub units, each one containing the drug. Then the dose is sum of the quantity of the drug in each sub unit and the functionality of individual sub-units. In contrast to Monolithic dosage forms multiple unit dosage forms offer several advantages. Controlled release systems can be developed by multi-unit dosage forms. The capsule comprised of a multiple unit pellets when administered, freely disperse in the GIT as a sub unit, each pellet acting as a separate drug delivery unit. Thus, maximizing drug absorption and reducing the peak plasma fluctuations, consequently, potential side effects can be minimized without imparting drug bioavailability [7]. Methods of preparation of multiple unit dosage forms To understand the complete strategy of the multiple unit dosage forms, it is necessary to have a brief idea regarding how pellets are prepared and principles involved in it. Pelletization This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small, free flowing, spherical or semi spherical pellets Available online: September Issue 2212
5 where size range typically from mm [8]. The most widely used Pelletization processes in pharmaceutical industries are, Extrusion Spheronization Spherical Agglomeration Liquid-induced agglomeration Spray drying and spray congealing Melt-induced agglomeration. Cryopelletization MATERIALS Aquacoat ECD (30%), Acetyl tributyl citrate, Eudragit L30 D55, Triethyl citrate, Tween 80, Talc, and Sugar spheres. METHOD Standard Calibration Curve of Budesonide A 100 mg of Budesonide was transferred to a 100 ml of standard flask and then dissolved in to the required quantity of phosphate buffer ph 7.5 and then make up to the volume in 100 ml of standard flask. From this stock solution the aliquots of 5µg, 10µg, 15µg, 20µg, and 25µg/ml were withdrawn and volume made up to 10ml. The absorbance of the concentration was measured at 244nm using UV- spectrophotometer. Drug excipients compatibility study: In this study, the active pharmaceutical ingredient and excipients were mixed separately and stored at different conditions for a time period of 1 month. The physical properties (colour change) were monitored regularly. The change in the colour in any mixture was the basis for disregarding the study. Available online: September Issue 2213
6 Solution/suspension layering by matrix layer formulation Drug and polymer matrix layering on sugar spheres: The required quantity of sugar spheres (18/20#) were weighed and transferred into a fluidized bed processor and required quantity of acetyl tributyl citrate and talc were dissolved in specified volume of water. Required volume of aqua coat ECD was added to above solution under continuous stirring. Later required quantity of budesonide was dispersed in above suspension by stirring. This suspension was sprayed on sugar spheres by bottom spray technique. This drug-polymer layered pellets were further used for enteric coating. Enteric Coating by Using Eudragit L30 D55 The required quantity of drug-polymer matrix layered pellets were loaded into the FBC and required quantity of triethyl citrate, tween 80 and eudragit L30 D55 were dissolved in specified volume of water under continuous stirring for 20 min. Later required quantity of talc was added to the above solution and sprayed on drug-polymer matrix layered pellets in bottom spray FBC. Table:1 Composition of drug and polymer matrix coated pellets for the formulation trial (F1-F9) Name of the excipient Weight of the Excipients (gm/500gm batch) % of polymer F1 F2 F3 F4 F5 F6 F7 F8 F9 Budesonide Aqua coat ECD 30% Acetyl tri butyl citrate Talc Sugar spheres Purified water q.s q.s q.s q.s q.s q.s q.s q.s q.s Note: # the material balance would become 600gm only after enteric coating step. Available online: September Issue 2214
7 * Aquacoat ECD is a 30% suspension contained ethyl cellulose (30%), sodium lauryl sulphate ( %), cetyl alcohol ( %), (FMC Biopolymers). Table:2 Composition of enteric coated pellets for the formulation trials (F1-F9) Name of the excipient Weight of the Excipients (gm/500gm batch) % of polymer F1 F2 F3 F4 F5 F6 F7 F8 F9 Eudragit D30 L Tri ethyl citrate Talc Tween Water q.s q.s q.s q.s q.s q.s q.s q.s q.s Evaluation of formulation (capsules): Average Fill Weight of Capsule: Weigh an intact capsule. Open the capsule without losing any part of the shell and remove the contents as completely as possible. Weigh the shell. The weight of the contents is the difference between the weighings. Repeat the procedure with a further 19 capsules. Determination of the average weight = (Weight of 20 capsules (g)/20)*1000=...mg Dissolution studies: Dissolution studies were carried out by using USP Type-2 (Paddles with sinker) with 0.1N HC1 and ph 7.5 phosphate buffers as a dissolution medium. The samples were withdrawn for 2hours for 0.1N Hcl as a dissolution medium and 1-8 hours for ph 7.5 phosphate buffer and samples were analyzed by using HPLC and dissolution data was compared with the innovator product. Available online: September Issue 2215
8 RESULTS AND DISCUSSION Table:3 Calibration curve of Budesonide Figure:1 Calibration curve of Budesonide in Phosphate Buffer in ph 7.5 S. Concentration Absorbance at Figure:2 FT-IR spectrum of Budesonide Figure :3 FTIR Spectrum of Eudragit D30 L55 Available online: September Issue 2216
9 Figure :4 FTIR Spectrum of F9 Table: 4 drug excipients compatibility study: S.No Drug + Excipient Initial After 1 month After 1 month Compatible at at 1. Drug White powder NCC NCC Yes 2. Drug +Aquacoat ECD White suspension NCC NCC Yes 3. Drug+ Talc White powder NCC NCC Yes 4. Drug+ Acetyl tri butyl citrate White suspension NCC NCC Yes 5. Drug+ Eudragit L30 D55 6. Drug+ Triethyl citrate White suspension White suspension NCC NCC Yes NCC NCC Yes 7. Drug+ Tween 80 White powder NCC NCC Yes * NCC-No Colour Change Compatibility studies at different temperatures and relative humidity showed that the drug itself was stable at higher temperature and relative humidity, as well as compatible with all the above excipients Average fill weight: Weight of 20 capsules /20*1000 The Average fill weight of capsule was found to be= mg/20 = 359.7mg Available online: September Issue 2217
10 Dissolution studies: Table: 5 cumulative% drug release of budesonide MR capsules in the formulation trails and innovator product (3mg): Fig: 5 Dissolution Profile comparison of Formulation F1-F3 Fig: 6 Dissolution Profile comparison of Formulation F4-F6 Available online: September Issue 2218
11 Fig : 7 Dissolution Profile comparison of Formulation F1-F3 Fig:8 Dissolution Profile comparison of Optimized Formulation F9 and Innovator CONCLUSION The study was undertaken with an aim to formulate budesonide modified release capsules. The drug budesonide is corticosteroid and currently used for the treatment of Crohn s disease. Before going to develop the formulation, a detail product literature review was carried out to know about the innovator s type of dosage form available in market, weights, all other parameters and excipients used product and the patent status of the drug. The study was carried out by solution/suspension matrix layering, first drug and polymer solutions were mixed, coating was done on the sugar spheres; further enteric coating was done on the polymer matrix coated pellets. Different trails were conducted with various percentages of polymers and other excipients in the first (drug loading) and second stage (during enteric coating) and the formulation was finally optimized based on the Cumulative % drug release. The optimized pellets were evaluated for tests like average fill weight, assay and content uniformity. The in-vitro dissolution tests were performed for all trails. Dissolution profile of formulation F9 matched with the innovator s product and was found to be satisfactory. Stability studies were also performed; both accelerated and long term stability studies were conducted for two months. During this study, the formulation F9 was found to be stable and no differences in the assay, moisture content and release characteristics were noticed. Available online: September Issue 2219
12 REFERENCES 1. Vyas.P, Kharr, R.K., Controlled drug delivery- Concept and Advances. 1 st ed. Delhi: Vallabh Prakashan Publishers; Joseph, R.R., Vincent, H.L.L., editors. Controlled drug delivery: Fundamentals and applications. 2 nd ed. New York. Marcel Decker, Inc: : Florence, Juergen.S, Mathias.W- ph sensitive polymer blends used as coating materials to control drug release from spherical beads: Elucidation of the underlying Mass Transport Mechanisms. Pharma. Res.2005: 22:7. 4. Ghebre-Selassie. Pharmaceutical Pelletization Technology. New York. Marcel Deckker Inc.1989: 37: Thomas W.Y.L, Joseph, R.R. Controlled release drug delivery system. In: Alfonso, R.G. editor. Remingtons: The science and practice of pharmacy, 20 th ed. Philadelphia; Lippincott Williams and Wilkilns; 2000; 1: Schaefer, T. Holm, P.Kristensen, H.G., Melt Pelletization in a high shear mixer. Effect of Process variables and binder. Acta. Pharm. Nord. 1992; 4: Chien, Y.W. Novel Drug delivery Systems, 2 nd ed. New York: Marcel Dekker, Inc; 1992 : 50: Gamlen M.J. Pellet manufacture for controlled release. Manuf. Chem. 1985; 56: David, M.S., Chang, S.K. Dinesh, V.P., James, A.w., Diffuse- interface theory for structure formation and release behavior in controlled drug delivery system. 2007: 3: Available online: September Issue 2220
FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationFormulation and Development of Sustained Release Tablets of Valsartan Sodium
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of
More informationSTABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS
Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF ph INDEPENDENT TABLETS OF ATENOLOL 1 S. Mahaboob Basha*, 2 N. Srinivas Department of
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationskim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR
Available Online through ISSN: 0975-766X CODEN: IJPTFI Research Article www.ijptonline.com ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF LAMOTRIGINE BY KNEADING METHOD Gadhave M.V*, Mahakal A. J., Gaikwad
More informationFormulation and evaluation of sublingual tablets of lisinopril
Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets
More informationSTUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College
More informationFORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS
International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya
More informationPreparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules
Research Article Preparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules *Surya Kiran Vuddisa, Subramanian S., Sindhu Raavi Department of Pharmaceutics, PSG College
More information7. SUMMARY, CONCLUSION AND RECOMMENDATIONS
211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability
More informationFORMULATION DEVELOPMENT - A QbD Approach to Develop Extended Release Softgels
Seite 1 von 8 Share this story: Issue: April 2015, Posted Date: 3/30/2015 FORMULATION DEVELOPMENT - A QbD Approach to Develop Extended Release Softgels INTRODUCTION Soft gelatin capsules (softgels) continue
More informationPreparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums
1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue
More informationTransdermal Delivery of Newer Atypical Antipsychotics ABSTRACT
Transdermal Delivery of Newer Atypical Antipsychotics ABSTRACT Abstract Risperidone and olanzapine, newer atypical antipsychotics are highly effective and safer in the treatment of psychosis. A low dose
More informationFORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN
FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012
STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college
More informationFROM SOLVENT TO AQUEOUS COATINGS. (Out of the Frying Pan...) Ralph E. Pondell. Coating Place, Inc. P.O. Box
84-1 FROM SOLVENT TO AQUEOUS COATINGS (Out of the Frying Pan...) Ralph E. Pondell Coating Place, Inc. P.O. Box 930310 Verona, WI 53593 A number of reasons exist for the current high level of interest in
More informationFACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS
JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):348-352 Formulation and in vitro evaluation of modified
More informationEVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data
EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In
More informationThe Nitrofurantoin Capsules Revision Bulletin supersedes the currently official monograph.
Nitrofurantoin Capsules Type of Posting Revision Bulletin Posting Date 28 Dec 2018 Official Date 01 Jan 2019 Expert Committee Chemical Medicines Monographs 1 Reason for Revision Compliance In accordance
More informationAsian Journal of Research in Biological and Pharmaceutical Sciences Journal home page:
Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com DESIGN, DEVELOPMENT AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM
More informationAsian Journal of Research in Biological and Pharmaceutical Sciences
Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com APPLICATION OF FACTORIAL DESIGN AND OPTIMIZATION OF GLIMEPIRIDE SUSTAINED
More informationInternational Journal of Drug Research and Technology
Int. J. Drug Res. Tech. 2016, Vol. 6 (3), 141-149 ISSN 2277-1506 International Journal of Drug Research and Technology Available online at http://www.ijdrt.com Original Research Paper FORMULATION AND EVALUATION
More informationFORMULATION AND EVALUATION OF THEOPHYLLINE BILAYERED TABLETS USING HPC AS MATRIX MATERIAL
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF THEOPHYLLINE BILAYERED TABLETS USING HPC AS MATRIX MATERIAL
More informationFormulation and Evaluation
Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the
More informationBiopharmaceutics Dosage form factors influencing bioavailability Lec:5
Biopharmaceutics Dosage form factors influencing bioavailability Lec:5 Ali Y Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School of Pharmacy University of Sulaimani 09/01/2019
More informationFABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS
Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.
More informationLipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study)
Lipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study) Presented by Dr. AHMED ATEF DONIA, PH. D., Lecturer of Pharmaceutical Technology, Faculty of Pharmacy, Tanta
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF BILAYER TABLETS OF AMLODIPINE BESYLATE AND GLIMEPIRIDE 1 V.D.T. Basavaraju*, 2 Dr N.
More informationA STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE FORMS
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009 Research Article A STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE
More informationFeasibility of using natural gums for development of sustained release matrix tablet of itopride
Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 215, 7 (3):114-123 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Feasibility
More informationCHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR
CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral
More informationMEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON
Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY
More informationFormulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride.
Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 3(4), 105-109 Research Article ISSN: 0976-822X Formulation and Evaluation of Gastroretentive Dosage
More informationTENOFOVIR TABLETS: Final text for addition to The International Pharmacopoeia (June 2010)
June 2010 TENOFOVIR TABLETS: Final text for addition to The International Pharmacopoeia (June 2010) This monograph was adopted at the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com ENHANCEMENT OF SOLUBILITY OF RITONAVIR BY USING SOLID DISPERSION TECHNIQUE 1 K.Sai Saran*, 2 M.Srujan Kumar, 3 Dr.K.V.Subrahmanyam
More informationFormulation and evaluation of immediate release salbutamol sulphate
5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely
More informationFORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT OF COUGH
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Patel et al. Volume 3, Issue 5, 822-834. Research Article ISSN 2278 4357 FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT
More informationJournal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011
ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE
More informationCHAPTER-I DRUG CHARACTERIZATION & DOSAGE FORMS
CHAPTER-I DRUG CHARACTERIZATION & DOSAGE FORMS by: j. jayasutha lecturer department of pharmacy practice Srm college of pharmacy srm university DRUG CHARACTERIZATION: Pre-formulation studies will attempt
More informationNew formulas for successful drug delivery Hot-melt extrusion for enhanced solubility and bioavailability
New formulas for successful drug delivery Hot-melt extrusion for enhanced solubility and bioavailability Andreas Gryczke, an enabler in excipients Pharma Ingredients & Services. Welcome to more opportunities.
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com COMPARARISSION OF SOLUBILITY IMPROVEMENT OF CEFIXIME
More informationREVISION OF MONOGRAPH ON TABLETS. Tablets
March 2011 REVISION OF MONOGRAPH ON TABLETS Final text for addition to The International Pharmacopoeia This monograph was adopted by the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationGranulation Aggregation
Granulation Aggregation Wet granulation Solvent granulation (crust granules) Binder granulation (sticked granules) Granulation liquid Water Water + alcohol mixture Macromolecular colloidal solution i.e.:
More informationFormulation and evaluation of fast dissolving tablet of aceclofenac
International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj
More informationIon Exchange Resins. Unique Solutions to Formulation Problems
Ion Exchange Resins Unique Solutions to Formulation Problems Lyn Hughes Some of the common problems faced by formulators and how using ion exchange resins may be able to solve them are discussed. PHOTODISC,
More informationFORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
More informationENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP
Int. J. Chem. Sci.: 9(2), 20, 637-646 ISSN 0972-768X www.sadgurupublications.com ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP K. P. R. CHOWDARY *, K.
More informationPreparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5901-5907 Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release K.P.R. CHOWDARY* and MALLURU SUBBA
More informationFormulation and Evaluation of Acyclovir Liposomes
Krishna Mohan Chinnala and Rabinarayan Panigrahy., 217/ Formulation and evaluation of acyclovir RESEARCH ARTICLE International Research Journal of Pharmaceutical and Biosciences Pri -ISSN: 2394-5826 http://www.irjpbs.com
More informationFormulation and In Vivo Evaluation of Immediate Release Glimepiride Coated Pellets Using 3 2 Full Factorial design by Novel Liquid Layering Technology
Research Article ISSN: 0974-6943 Available online through http://jprsolutions.info Formulation and In Vivo Evaluation of Immediate Release Glimepiride Coated Pellets Using 3 2 Full Factorial design by
More informationRITONAVIRI COMPRESSI RITONAVIR TABLETS. Final text for addition to The International Pharmacopoeia (July 2012)
July 2012 RITONAVIRI COMPRESSI RITONAVIR TABLETS Final text for addition to The International Pharmacopoeia (July 2012) This monograph was adopted at the Forty-sixth WHO Expert Committee on Specifications
More informationChemate and Chowdary, IJPSR, 2012; Vol. 3(7): ISSN:
IJPSR (2012), Vol. 3, Issue 07 (Research Article) Received on 18 March, 2012; received in revised form 25 April, 2012; accepted 22 June, 2012 A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION
More informationRP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form
RP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form S. LAVANYA* 1, SK. MANSURA BEGUM 1, K. NAGAMALLESWARA RAO 2, K. GAYATHRI DEVI 3 Department of pharmaceutical
More informationThe Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation
METHOCEL Premium Cellulose Ethers Application Data The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation INTRODUCTION Hydrophilic matrices
More informationVolume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL
Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya
More informationARTESUNATE TABLETS: Final text for revision of The International Pharmacopoeia (December 2009) ARTESUNATI COMPRESSI ARTESUNATE TABLETS
December 2009 ARTESUNATE TABLETS: Final text for revision of The International Pharmacopoeia (December 2009) This monograph was adopted at the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationCONTROLLED-RELEASE & SUSTAINED-RELEASE DOSAGE FORMS. Pharmaceutical Manufacturing-4
CONTROLLED-RELEASE & SUSTAINED-RELEASE DOSAGE FORMS Pharmaceutical Manufacturing-4 The improvement in drug therapy is a consequence of not only the development of new chemical entities but also the combination
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationInternational Journal of Medicine and Pharmaceutical Research
International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating
More informationA FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN AND SOLUTOL HS15
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN
More informationResearch Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form
Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Gowekar NM, Lawande YS*, Jadhav DP, Hase RS and Savita N. Gowekar Department
More informationContinuous Granulation Using a Twin-Screw Extruder. Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016
Continuous Granulation Using a Twin-Screw Extruder Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016 What is a twin screw extruder and how to use it for continuous granulation? Dry feed:
More informationFormulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers
Pharm Methods, 2017; 8(1): 45-53 A multifaceted peer reviewed journal in the field of Pharm Analysis and Pharmaceutics www.phmethods.net www.journalonweb.com/phm Research Article Formulation development
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VALSARTAN
More informationFormulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium
Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast
More informationFormulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting
Human Journals Research Article May 2015 Vol.:3, Issue:2 All rights are reserved by Srilakshmi N et al. Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting Keywords:
More information3.1 Background. Preformulation Studies
Preformulation Studies 3.1 Background Delivery of any drug requires a suitable dosage form to get optimum therapeutic effects. The development of such dosage forms fundamental properties of the drug molecule
More informationAvailable Online through Research Article
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND DEVELOPMENT OF VALSARTAN IMMEDIATE RELEASE TABLET 1 M.Usha*, 2 Y.Raya Jaya Rao, 3 P.Prem Kumar, 4
More informationTable 1. Coating Parameters
ACRYL-EZE Aqueous Acrylic Enteric System Application Data Performance Characteristics of Acryl-EZE, Aqueous Acrylic Enteric System Eudragit L1-55 is a copolymer of methacrylic acid and ethyl acrylate (1:1
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF ZOLMITRIPTAN 1 Jalendhar Nakka *, 2 M.Srujan Kumar, 3 Dr.K.V.Subrahmanyam
More informationSENTRY TM POLYOX Water Soluble Resins
SENTRY TM POLYOX Water Soluble Resins Technical Information on Stability Introduction Key Points Antioxidants SENTRY POLYOX WSR resins consist of a family of high molecular weight polyethers with nominal
More informationFORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao
More informationMixed Hydrotropy: Novel Science of Solubility Enhancement
Research Paper Mixed Hydrotropy: Novel Science of Solubility Enhancement R. K. MAHESHWARI* AND Y. JAGWANI Shri G. S. Institute of Technology and Science, 23-Park Road, Indore-452 003, Madhya Pradesh, India
More informationLubriTose Mannitol Michael Crowley, Director of R&D, Excipients
LubriTose Mannitol Michael Crowley, Director of R&D, Excipients Introduction Michael Crowley Director of R&D Excipients 158 St. Highway 320 Norwich, NY 13815 PH 315-802-5970 Michael.Crowley@Kerry.com 2
More informationPharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs
Mansoura University Faculty of Pharmacy Department of Pharmaceutics Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Thesis presented by Ali Saeed
More informationINTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Development and characterization of valsartan and hydrochlorothiazide film coated tablet Satyam Pandey*, Aditya Nath Pandey, Dinesh singh, Ankit mishra
More informationGlobal College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India
IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS
More informationIJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page:
IJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page: ISSN: 2320-2831 Research article Open Access Method development and validation of tenofovir disoproxil fumerate and emtricitabine in combined tablet
More informationInternational Journal of Pharma Sciences and Scientific Research
Research Article International Journal of Pharma Sciences and Scientific Research ISSN 2471-6782 Open Access Formulation, development and evaluation of rivaroxaban tablets by using solubility enhancement
More informationDESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and
More informationMaisammaguda, Dulapally, Secundrabad.
121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY
More informationImmediate Release Formulation of Valsartan Capsule and Evaluation of its Compatibility by Nonthermal Methods
American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Immediate Release Formulation of Valsartan Capsule and Evaluation of its Compatibility by Nonthermal Methods Sudhir. Maddela
More informationFLORITER. New Technology for Innovative Formulation Design.
FLORITER New Technology for Innovative Formulation Design www.tomitaph.co.jp FLORITE Dramatically Change Your Formulation FLORITE is synthetic Calcium Silicate with exceptional liquid absorbency and excellent
More informationA Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac
Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*
More informationDevelopment and Validation of a New Uv Method for the Analysis of Rebamipide
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.3, No.3, pp1270-1274, July-Sept 2011 Development and Validation of a New Uv Method for the Analysis of Rebamipide Praveen
More informationFormulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets
Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets M. Sunitha Reddy 1, B. Sharath Reddy 1, S. Muhammed Fazal Ul Haq 1 Centre of Pharmaceutical Sciences, Jawaharlal Nehru Technological
More informationVIVAPHARM PVP/VA. Copovidone, Ph.Eur. USP/NF, JPE, E. The Ultimate Tablet Binder for All Processing Technologies
VIVAPHARM PVP/VA Copovidone, Ph.Eur. USP/NF, JPE, E 1208, FCC The Ultimate Tablet Binder for All Processing Technologies Direct Compression Dry Granulation Hot Melt Extrusion Wet Granulation VIVAPHARM
More informationTablet is a major category of solid dosage forms which are widely used worldwide. Extensive information is required to prepare tablets with good
TABLET PRODUCTİON Tablet is a major category of solid dosage forms which are widely used worldwide. Extensive information is required to prepare tablets with good quality at high standards. Based on preformulation
More informationFormulation and evaluation of valsartan pulsincap drug delivery system
IJPAR Vol.4 Issue 1 Jan-Mar-2015 Journal Home page: ISSN: 2320-2831 Research article Open Access Formulation and evaluation of valsartan pulsincap drug delivery system Anil Babu G*, V.Vau Naik, Ankarao
More informationFormulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting
Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,
More informationFormulation and evaluation of oral dispersible tablets of aripiprazole
IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,
More informationDirect Compression. With the right ingredients it s a simple, cost-effective manufacturing process
Direct With the right ingredients it s a simple, cost-effective manufacturing process TM Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Speed and savings sounds good to us
More informationCompliance. Should you have any questions, please contact Behnaz Almasi, Associate Scientific Liaison ( or
Extended-Release Tablets Type of Posting Revision Bulletin Posting Date 30 Mar 2018 Official Date 01 Apr 2018 Expert Committee Chemical Medicines Monographs 3 Reason for Revision Compliance In accordance
More informationIJRPB 1(5) September October 2013 Page 629
FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ANTI- HYPERTENSIVE DRUG METOPROLOL SUCCINATE Koteswararao P 1*, Duraivel S 1, Sampath Kumar KP 2, Debjit Bhowmik 3 1. Nimra College Of Pharmacy,Vijayawada,
More informationImproving Micromeritic Properties of Ibuprofen: An Agglomeration Approach
Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017 Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach Md. Sazzadul Islam and Md. Saiful Islam Pathan Department of Pharmacy, State
More informationFormulation and evaluation of oro-dispersible tablets of lafutidine
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationInnovations in Design: NIA-West. Missy Lowery, MSc Head of Integrated Marketing Capsugel, now a Lonza company 11/13/2017
Innovations in Design: NIA-West Missy Lowery, MSc Head of Integrated Marketing Capsugel, now a Lonza company 11/13/2017 1 Innovations in Design: How Do You Stand Out? If all other competitors are the same
More information