EVIDENCE-BASED DERMATOLOGY: STUDY. Measuring Atopic Eczema Severity Visually
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1 EVIDENCE-BASED DERMATOLOGY: STUDY SECTION EDITOR: MICHAEL BIGBY, MD; ASSISTANT SECTION EDITORS: DAMIANO ABENI, MD, MPH; ROSAMARIA CORONA, DSc, MD; URBÀ GONZÁLEZ, MD, PHD; ARBAR A. QURESHI, MD, MPH; MOYSES SZKLO, MD, MPH, DrPH; HYWEL WILLIAMS, MSc, PhD, FRCP A cooperative effort of the Clinical Epidemiology Unit of the Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of Dermatology Measuring Atopic Eczema Severity Visually Which Variables Are Most Important to Patients? Carolyn R. Charman, BM, BCh, MRCP; Andrea J. Venn, PhD; Hywel Williams, MSc, PhD, FRCP; Michael Bigby, MD Background: There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult. Objective: To provide a rationale for simplifying and standardizing objective atopic eczema scoring by investigating which visual variables provide the best measure of disease severity from the patient s perspective. Setting: The dermatology outpatient department at the Queen s Medical Centre, University Hospital in Nottingham, and 5 local general practices. Patients: One hundred eighty individuals with atopic eczema. Interventions: Clinical examination with scoring of 7 clinical signs and disease extent, followed by regression analyses of visual variable scores against a patient-rated measure of current disease severity. Results: Objective measurements account for only a quarter of the variation in patient-rated disease severity. Three clinical signs were independent predictors of patient-rated disease severity: excoriations, erythema, and edema/papulation. Disease extent measurements do not reflect patient-rated disease severity in a linear manner, with mean severity scores increasing little above 30% body surface area involvement. Conclusions: From the patient s perspective, the measurement of 3 clinical signs excoriations, erythema, and edema/papulation provides as much information about current atopic eczema severity as more complex scoring systems that measure multiple clinical signs and disease extent. The simplicity of the Three Item Severity score, a previously published atopic eczema score based on measurement of these 3 clinical signs, makes it a suitable tool for research studies or clinical practice. Arch Dermatol. 2005;141: Author Affiliations: Department of Dermatology, Queen s Medical Centre (Drs Charman and Williams); and Department of Epidemiology and Public Health, University of Nottingham (Dr Venn); Nottingham, England. MEASURING SKIN DISEASE severity is a central part of dermatologic practice. In the outpatient clinic and in therapeutic trials it is essential to have some method of recording disease activity to ensure that health care interventions are effective. In common with many skin diseases, there are no serologic markers that accurately reflect atopic eczema severity, and, therefore, measurements are primarily based on signs and symptoms. 1 Although management revolves around symptom control, traditionally greater emphasis has been placed on visual assessments of clinical signs and disease extent by physicians, especially in the clinical trial setting. In a recent review 2 of 93 randomized controlled clinical trials of atopic eczema therapy published between 1994 and 2001, scoring of clinical signs was the most widely used form of outcome measure (91% of trials), with disease extent recorded in 67% of trials. Symptoms were assessed in 86% of trials but were frequently combined with clinical signs in composite scoring systems, with relatively low weighting given to patient-rated symptoms compared with physician-rated clinical signs. Furthermore, quality of life was measured in only 3% of the trials. The most widely used clinical scoring system in this review was the SCORAD (SCORing Atopic Dermatitis) index, in which 60% of the total score is based on clinical signs and 20% is based on disease extent, with only 20% weighting for patient symptoms. 3-5 Given that objective scoring systems are playing such a central role in atopic eczema trials, it is essential that the visual variables 1146
2 being measured are important to patients and that they reflect current disease severity in a clinically meaningful way to practicing physicians. From the physician s viewpoint there has been a general lack of consensus as to which visual variables best reflect atopic eczema severity. Given that atopic eczema is one of the most common inflammatory diseases in dermatology, this lack of standardization in disease scoring has been astounding, with more than 50 different clinical scoring systems being identified in the 93 randomized controlled clinical trials published between 1994 and 2001 alone. 2 These scoring systems comprised more than 30 different descriptions of clinical signs and more than 20 different methods of scoring disease extent, with widely variable weighting given to different visual variables across the randomized controlled clinical trials. 2 In an era of patient-centered and evidence-based medicine, such lack of standardization not only makes the comparison of results and the production of systematic reviews difficult but also challenges the meaningful interpretation of individual studies because researchers are selecting their own combination of signs in the absence of formal validity testing. 6 Given the lack of consensus on which clinical signs are most important from the dermatologist s perspective, the aim of this study is to investigate which visual variables provide the best measure of atopic eczema severity from the patient s perspective, around which management ultimately revolves. METHODS PATIENTS A total of 180 patients (age range, 1-67 years; median age, 11 years; 51% female) with atopic eczema were recruited for the study. Of these, 110 patients were recruited consecutively from the dermatology outpatient department at the University Hospital in Nottingham. Another 70 patients were recruited from 5 local general practices by writing to all patients listed with a diagnosis of atopic eczema and arranging local interviews in the general practice at a convenient time for the patients. The ethnicity of the 180 patients was as follows: 153 (85.0%) were white, 15 (8.3%) were Asian, and 12 (6.7%) were Afro-Caribbean. All the patients satisfied the UK Working Party s refinement of the diagnostic criteria of Hanifin and Rajka for atopic eczema. 7 Ethical permission for the study was obtained from the local ethics committee before commencement of the study. ASSESSMENTS All the patients were examined by a single dermatologist (C.R.C.). For practical purposes, 7 clinical signs were recorded: erythema, edema/papulation, oozing/crusting, excoriations, lichenification, dryness, and cracking. We selected these clinical signs because they are measured in 3 of the most widely used and validated atopic eczema scoring systems currently available: the SCORAD index (erythema, edema/papulation, oozing/ crusting, excoriations, lichenification, and dryness), 3 the Eczema Area and Severity Index (erythema, edema/papulation, excoriations, and lichenification), 8,9 and the Six-Area, Six-Sign Atopic Dermatitis severity score (erythema, excoriations, oozing/ crusting, lichenification, dryness, and cracking). 10 The average intensity of each clinical sign was graded on a scale from 0 to 3 (0=absent, 1=mild, 2=moderate, and 3=severe) at a representative body site, per the SCORAD protocol. 3 Dryness was assessed in noninflamed skin. Disease extent was measured using the rule of nines and was drawn directly on the SCORAD evaluation sheet for calculation, per the SCORAD protocol. The objective SCORAD index (possible score of 0-83) was calculated as A/5 7B/2, where A is the percentage disease extent (0-100) and B is the sum of 6 clinical signs (possible score of 0-18). 3,4 To assess current atopic eczema severity from the patient s perspective, a variety of questions were pilot tested before the study. The question How much bother has your/your child s eczema caused over the last 3 days? (scale of 0-10) was found to be more acceptable and meaningful to patients than asking them to directly rate their disease severity. The bother caused by the eczema provides a good reflection of the overall impact of the disease and patients requirements for health care intervention. The term bother has previously been used successfully in the development of symptom-based outcome measures for eczema and asthma, 11,12 and it was easily understood by all patients when pilot tested before the study. Alternative phrases, such as How much trouble has your eczema caused? may have provided similar information, but such terms have not, to our knowledge, been used previously in published outcome measure studies. Three days is the period for subjective assessment used in the SCORAD index, and it was used to minimize fluctuations in the visual variables under assessment. To provide construct validity for the measurement of bother, quality of life and itch were also measured. Quality of life was assessed using the Dermatology Life Quality Index (DLQI) 13 for patients older than 16 years (n=68) and the Children s Dermatology Life Quality Index (CDLQI) 14 for children aged 4 to 16 years (n=76). Itch is a dominant symptom in atopic eczema, and it was assessed on a visual analog scale raging from 0 to 10 during the previous 3 days, per the SCORAD protocol. For young children, information about disease severity, itch, and quality of life was obtained from the child and the parents depending on the child s age and understanding. STATISTICAL ANALYSIS Statistical analysis was performed using a software program (SPSS for Windows version 11.0; SPSS Inc, Chicago, IL). The mean patient-rated disease severity score (on a scale from 0-10) was computed for each level of the clinical sign scores (grades 0-3) and was compared using 1-way analysis of variance. A test for trend across the levels was performed to assess whether each relation was linear. A scatterplot was used to assess the univariate relation between disease extent and patient-rated disease severity, and a correlation coefficient (r) was computed. Multiple linear regression analyses were performed to determine how much variability in patient-rated disease severity each variable explained and to determine which variables were independent predictors of patient-rated disease severity. Variables that did not display a linear relation with patient-rated disease severity were fitted as categorical factors, and coefficients were obtained for each level of the factor relative to the lowest. Residual plots were produced to check the model assumptions held. Correlation coefficients (Spearman or Pearson r) were calculated for patient-rated disease severity against total objective scores, quality of life, and itch. RESULTS CLINICAL SIGNS The distribution of patient-rated disease severity scores is shown in Figure 1. All 7 clinical signs were significantly associated with current disease severity from the patient s perspective. Patient-rated disease severity increased in a linear manner with increasing severity of ery- 1147
3 30 Table 1. Results of Univariate Regression Analysis of Clinical Signs and Patient-Rated Disease Severity* Patients, No Clinical Sign Effect Estimate (95% CI) P Value Adjusted R 2 Excoriations 1.25 ( ) Edema and papulation 1.04 ( ) Erythema 1.48 ( ) Cracking 1.08 ( ) Oozing and crusting 0.96 ( ) Lichenification 0.54 ( ) Patient-Rated Disease Severity Score Figure 1. Distribution of patient-rated disease severity scores (N=180). 10 Abbreviation: CI, confidence interval. *Dryness fitted as a categorical variable. Effect estimates for dryness grades 1, 2, and 3 were 1.72 (95% CI, ), 2.46 (95% CI, ), and 1.79 (95% CI, ), respectively, compared with grade 0 (adjusted R 2 = 0.05; P =.005). Indicates the unit increase in patient-rated disease severity score (possible score of 0-10) predicted by each unit increase in clinical sign grade (grades 0-3) or, as in the case of dryness, for each grade of the score relative to grade 0 dryness. The proportion of variation in patient-rated disease severity predicted by the measurement of each clinical sign. 9 Mean Patient-Rated Disease Severity Score (0-10) Excoriations Edema and Papulation Erythema Cracking Oozing and Crusting Lichenification Dryness Clinical Sign Grade (0-3) Figure 2. Relationship between clinical sign grades and current patient-rated disease severity scores. thema, edema/papulation, oozing/crusting, excoriations, lichenification, and cracking (Figure 2). Dryness was the only clinical sign that did not display a linear trend, with patient-rated disease severity increasing from dryness grade 0 to grade 2 but decreasing slightly in patients with grade 3 dryness. The results of univariate regression analysis given in Table 1 demonstrate how much variability in patientrated disease severity can be explained by each clinical sign separately. Individually, each clinical sign accounts for only a small proportion of the overall variation (adjusted R 2 ). Measurements of excoriations provided the best predictor of current disease severity from the patient s perspective, accounting for almost a fifth Table 2. Results of Multiple Regression Analysis Showing Variables Independently Associated With Patient-Rated Disease Severity Clinical Sign Effect Estimate (95% CI)* P Value Adjusted R 2 Excoriations 0.95 ( ) Edema and papulation 0.50 ( ).03 Erythema 0.68 ( ).03 Abbreviation: CI, confidence interval. *Indicates the unit increase in patient-rated disease severity score (possible score of 0-10) predicted by each unit increase in clinical sign grade (grades 0-3). The proportion of variation in patient-rated disease severity predicted by the measurement of all 3 clinical signs. (19.0%) of the variation in patient-rated disease severity scores. For every 1-point increase in erythema and excoriations, patient-rated disease severity increased on average by 1.5 and 1.25, respectively (effect estimate). In a multiple linear regression model, all 7 clinical signs together predicted only a quarter of the variation in patientrated disease severity (adjusted R 2 =0.25). Three variables were identified as independent predictors of patientrated disease severity: excoriations, edema/papulation, and erythema (Table 2). Measurement of these 3 clinical signs accounted for a similar amount of variation (adjusted R 2 =0.25). These 3 variables remained significant independent predictors of patient-rated disease severity with similar effect estimates after adjustment for age and sex. DISEASE EXTENT Patient-rated disease severity was positively correlated with disease extent, although Figure 3 suggests a nonlinear relation (Spearman r=0.44; P.001). To investigate this correlation further, we categorized disease extent into 5 groups representing 0% to 10% (n=56), 11% to 20% (n=69), 21% to 30% (n=22), 31% to 50% (n=17), and 51% 1148
4 or greater (n=16). Comparison of the means indicates a greater increase in patient-rated disease severity with disease extent across the lower values (0%-30% area involvement) than across the higher values (means, 3.64, 4.59, 6.05, 6.88, and 6.06, respectively; P.001 for betweengroup effect). Of the patients with 20% or less skin involvement, almost a quarter (29/125;23.2%) rated the bother causedbytheireczemaas7orgreater(onascalefrom0-10). The median age of these 29 patients with 0% to 20% skin involvement was 8.6 years (range, years; 62% female), and the main body sites involved were the hands or feet (12/29; 41%), the limbs (11/29; 38%), and the head and neck (6/29; 21%). In contrast, the hands or feet and head and neck were the main site of involvement in only 16% and 14% of the total sample, respectively. Disease extent on its own explained 14.0% of the variability in patient-rated disease severity (adjusted R 2 =0.14; P.001). However, when included in the multiple linear regression model with the clinical signs, disease extent added no statistically significant extra information about patientrated disease severity vs measuring excoriations, edema/ papulation, and erythema alone (adjusted R 2 =0.26 vs 0.25). OBJECTIVE SCORAD INDEX The sum of scores for excoriations, erythema, and edema/ papulation (possible score of 0-9) was at least as closely correlated with patient-rated disease severity as the objective component of the SCORAD index (excoriations, erythema, edema/papulation, oozing/crusting, lichenification, dryness, and disease extent: possible score of 0-83) (Pearson r=0.51 and 0.49 and adjusted R 2 =0.25 and 0.23, respectively; P.001). QUALITY-OF-LIFE AND ITCH SCORES Correlation between patient-rated disease severity (possible score of 0-10) and quality-of-life scores (possible score of 0-30) was high (Spearman r=0.65, n=86 for the CDLQI and Spearman r=0.64, n=54 for the DLQI; P.001 for both). Similarly, correlation between patient-rated disease severity and itch (possible score of 0-10) was high (Spearman r=0.86, n=200; P.001). The sum of scores for excoriations, erythema, and edema/papulation correlated as highly with the CDLQI as the more complex objective SCORAD (Spearman r=0.65 and 0.69, respectively; P.001 for both), although correlation coefficients against the DLQI did not reach statistical significance (Spearman r=0.20 and 0.11; P=.16 and.42, respectively). Similarly, the sum of scores for excoriations, erythema, and edema/papulation correlated as highly with itch as the more complex objective SCORAD (Spearman r=0.48 and 0.49, respectively; P.001 for both). COMMENT MAIN STUDY FINDINGS Patient-Rated Disease Severity Score Body Surface Area Involved, % Figure 3. Relationship between disease extent and patient-rated disease severity scores (r=0.44). Physicians have traditionally placed great emphasis on visual assessments to grade atopic eczema severity, and such measurements have formed the basis of therapeutic trials in recent years. 2 However, this study demonstrates that visual skin changes predict only a quarter of the variation in patient-rated disease severity seen in hospital and community patients, emphasizing the need for inclusion of more patient-based assessments to provide a comprehensive and clinically meaningful picture of disease severity. 2,11,13,14 With the confusing array of objective atopic eczema scoring systems in current use, this study provides a rationale for the simplification of visual variable measurements and improves our understanding of how these measurements translate into clinical practice. Although the assignment of equal weighting to clinical signs is preferred to keep scoring systems simple, this study demonstrates that the commonly measured clinical signs are not of equal importance to patients and that many visual variables change in parallel with each other, making complicated scoring systems unnecessary from the patient s perspective. Finally, although disease extent is commonly included in atopic eczema scoring systems, this study demonstrates that it does not reflect patient-rated disease severity in a linear manner; when assessing the relevance of numerical changes in such scores, this finding needs to be taken into account. THE THREE ITEM SEVERITY SCORE Three clinical signs provide the best measure of current disease severity from the patient s perspective: excoriations, erythema, and edema/papulation. Excoriations provide a visual reflection of pruritus, and erythema and edema/ papulation reflect acute inflammation. A simple scoring system comprising a measurement of these 3 variables (total score, 0-9) has previously been described in the literature as a simplified version of the SCORAD index called the Three Item Severity (TIS) score, 15 although the 3 variables were originally chosen on clinical grounds rather than on patient assessments. Other clinical signs in this study included cracking and oozing/crusting, both of which were associated with high severity scores. However, severe cracking was uncommon in our patient population, and this clinical sign added no significant extra information about current disease severity. Similarly, oozing/crusting was sufficiently related to other acute variables in the regression analysis to make its measurement redundant. Lichenification is one of the more difficult clinical signs to grade accurately, 3,4,16 but it is often included in clinical scoring systems to provide a measure of disease chronicity. How- 1149
5 ever, lichenification can take several weeks to resolve, even after successful treatment has brought the acute inflammation and symptoms under control, and, therefore, does not provide an accurate measure of current disease activity, as demonstrated in this study. Dryness alone is associated with less bother than other variables and does not show a linear relationship with patient-rated disease severity, possibly reflecting increased emollient application in patients with the most severe symptoms or decreased dryness in acute exudative disease. Given that the median randomized controlled clinical trial duration in recent years was only 6 weeks, 2 the inclusion of these long-term variables to assess short-term changes in disease severity can make interpretation of results difficult and could potentially dilute any patient benefit detected. DO WE NEED TO MEASURE DISEASE EXTENT? Patient-rated disease severity increases as disease extent increases, but the relationship is nonlinear. A threshold effect is observed whereby mean severity scores show little increase above approximately 30% body surface area involvement. Whether the high severity scores seen in patients with limited disease reflect the limits of those patients experience is unclear from this cross-sectional study. Nevertheless, patients perceptions of their disease severity ultimately dictate their demand for treatment, regardless of their disease severity relative to other patients. Disease extent and intensity were highly correlated in this study, and from the patient s perspective, disease extent measurements added no significant information to that obtained by measuring the 3 clinical signs mentioned herein because the latter reflected disease severity more closely. From a measurement perspective, accurate assessments of percentage of skin involvement are time-consuming and are subject to wide interobserver variation. 4,17 More important, although percentage of skin involvement may provide a tidy quantitative figure for analysis, the human body is not a uniform structure but consists of body sites of varying size and functional importance to patients. In clinical practice, the location of skin involvement is often more important to patients than is percentage of involvement per se, with involvement of small but functionally and cosmetically important areas, such as the hands, feet, and face, frequently being associated with significant morbidity. In this study, patients with limited disease and high patient-rated severity scores were more likely to have hand or foot eczema as the main site of involvement compared with the total sample of patients, reflecting the functional importance of these sites, particularly in young children. IMPLICATIONS FOR MEASURING ATOPIC ECZEMA SEVERITY IN CLINICAL TRIALS AND DAILY PRACTICE Although patient-based assessments, such as quality-oflife measurements, 13,14 patient global assessments, 2 and the patient-oriented eczema measure 11 (POEM), provide the most pragmatic measure of atopic eczema severity, objective measures are likely to remain widely used because they can provide useful information when comparing patients across different cultural backgrounds, which may affect subjective reporting. In the clinical trial setting, researchers may want to use a validated scoring system, such as the SCORAD index or the Eczema Area and Severity Index, to provide detailed information about the disease process and to capture small changes in visible disease severity. However, additional information about visible skin changes does not necessarily translate into additional information about the illness experienced by the patient. When using such complex scoring systems it is often difficult to interpret whether a small change, such as 8 of a possible 103 points, is of real meaning to the patient rather than of academic interest only, or even simply a reflection of observer variation. It is also important to recognize that scoring systems that incorporate measurements of disease extent and skin dryness do not reflect patient-rated disease severity in a linear manner. Therefore, we suggest that researchers who use these composite scoring systems present the data for changes in individual variables (clinical signs and disease extent) alongside the total score to enable more meaningful interpretation by practicing physicians. Depending on the study design, researchers not wanting to use a complex scoring system can record as much clinically meaningful information from the patient s perspective by using the TIS score, the validity of which has been confirmed in this study. Because the TIS score is derived from elements of the SCORAD index, it is not surprising that it has showed high correlation with the SCORAD index in the original description of the index (r=0.86) 15 and in the present study (r=0.82). The 3 clinical signs are graded as in the SCORAD index, and standardization of scoring can be improved by using the definitions and photographs in the SCORAD protocol (available at 3 Reliability data for the 3 clinical signs in the TIS score have been documented previously during validation of the SCORAD index and vary among studies, although the measurement of edema and papulation is most likely to vary between or within observers. 3,4,15,16 In the original description of the TIS score, the total score showed fair interobserver agreement ( =0.58). 15 The 3 clinical signs have shown sensitivity to change in clinical trials using the SCORAD index, 16 although further trials are needed to confirm the sensitivity of the TIS score in different patient populations. The TIS score was originally described for routine clinical practice and for prescreening for clinical trials, but it has been used successfully as a primary outcome measure in a recent randomized, double-blind, parallel-group study 18 of topical corticosteroid use, using a score of 4 or higher (of a possible 9) to indicate a relapse and 1 or lower to indicate remission. In addition to its potential use for screening and monitoring in clinical trials, the simplicity of the TIS score makes it suitable for use in the outpatient clinic or general practice, particularly for clinical audit. The limitations of all forms of visual scoring systems should be recognized. Visual assessments reflect a single snapshot in time and do not comprehensively capture the chronic, fluctuating nature of the atopic eczema. Furthermore, accurate grading of clinical signs and disease extent can be time-consuming and subject to wide interobserver 1150
6 Section Editor s Note Although the statistical methods used in this study are complicated, the conclusion is simple. Determining the degree of excoriations, erythema, and edema and papulation of a representative area in patients with atopic dermatitis correlates bests with the patient s perception of his or her disease severity. Scoring these signs of disease activity provides as much information about current atopic eczema severity from the patient s perspective as more complex scoring systems that measure multiple clinical signs and disease extent. A1-wayanalysisofvarianceislikeattestinwhich1variable is related to multiple independent variables. Correlation coefficients range from 1 (perfect inverse correlation) to 1 (perfect positive correlation), with 0 representing no correlation. The tests of significance for correlation coefficients measure the likelihood that the correlation is due to chance. Linear regression is used to determine the best slope of the line that relates 2 variables. Readers interested in beginning to understand the statistical methods used in this article should read Glantz SA. Primer of Bio-Statistics. 3rd ed. New York, NY: McGraw-Hill; variation, which could potentially overshadow small changes in disease severity. 16,17 The assessment of erythema can be particularly difficult in black skin, despite being one of the most widely measured clinical signs. 19 CONCLUSIONS Michael Bigby, MD Objective clinical scoring systems have a defined but limited role in the assessment and monitoring of disease severity in children and adults with atopic eczema. From the patient s perspective, the current array of visual measurements is not necessary to provide a clinically meaningful reflection of disease severity, and visual scoring can be simplified without losing important information. From the physician s perspective, standardization and simplification of scoring will allow improved interpretation and comparison of disease outcomes. In a disease dominated by symptoms, visual assessments should be used to supplement but notreplacepatient-basedsymptommeasures 2,11 andqualityof-life scores, 13,14 which have remained underused in recent years and can ultimately provide more valuable information about day-to-day disease severity from the patient s perspective, around which management revolves. Accepted for Publication: March 22, Correspondence: Carolyn R. Charman, BM, BCh, MRCP, Department of Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, England Author Contributions: Study concept and design: Charman and Williams. Acquisition of data: Charman. Analysis and interpretation of data: Charman, Venn, and Williams. Drafting of the manuscript: Charman. Critical revision of the manuscript for important intellectual content: Charman, Venn, and Williams. Statistical analysis: Charman and Venn. Obtained funding: Charman and Williams. Administrative, technical, and material support: Charman. Study supervision: Williams. Financial Disclosure: None. Funding/Support: This work was supported by a Health Services Research Training Fellowship funded by the former National Health Service Research and Development Board, Trent Region, Sheffield, England. Role of the Sponsor: The sponsor had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript. Disclaimer: Dr Charman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Acknowledgment: We are indebted to the patients and the outpatient reception staff who helped with this study and to the Trent Focus Group and general practices for their time and administrative assistance. REFERENCES 1. Finlay AY. Measurement of disease activity and outcome in atopic dermatitis. Br J Dermatol. 1996;135: Charman C, Chambers C, Williams H. Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring? J Invest Dermatol. 2003;120: European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD index. Dermatology. 1993;186: Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1997;195: Gelmetti C, Colonna C. The value of SCORAD and beyond: towards a standardized evaluation of severity? Allergy. 2004;59(suppl 78): Chren MM. Giving scale new meaning in dermatology [editorial]. Arch Dermatol. 2000;136: Williams HC, Burney PG, Hay RJ, et al. The UK Working Party s diagnostic criteria for atopic dermatitis, I: derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131: Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M; EASI Evaluator Group. The Eczema Area and Severity Index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10: Barbier N, Paul C, Luger T, et al. Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme. Br J Dermatol. 2004;150: Berth-Jones J. Six-area, six-sign atopic dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis. Br J Dermatol. 1996;135(suppl 48): Charman CR, Venn AJ, Williams HC. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients perspective. Arch Dermatol. 2004;140: Steen N, Hutchinson A, McColl E, et al. Development of a symptom based outcome measure for asthma. BMJ. 1994;309: Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI): a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19: Lewis-Jones MS, Finlay AY. The Children s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132: Wolkerstorfer A, De Waard Van Der Spek FB, Glazenburg EJ, Mulder PGH, Oranje AP. Scoring the severity of atopic dermatitis: three item severity score as a rough system for daily practice and as a pre-screening tool for studies. Acta Derm Venereol. 1999;79: Charman C, Williams H. Outcome measures of disease severity in atopic eczema. Arch Dermatol. 2000;136: Charman CR, Venn AJ, Williams HC. Measurement of body surface area involvement in atopic eczema: an impossible task? Br J Dermatol. 1999;140: Berth-Jones J, Damstra RJ, Golsch S, et al. Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study. BMJ. 2003;326: Ben-Gashir MA, Hay RJ. Reliance on erythema scores may mask severe atopic dermatitis in black children compared with their white counterparts. Br J Dermatol. 2002;147:
7 the risk-benefit ratio. This case illustrates the benefits of thalidomide therapy for patients with NL, and further studies are needed to understand the full potential of this unique drug. Accepted for Publication: April 28, Correspondence: Tarun Kukreja, MD, Center for Dermatological and Cosmetic Surgery, Washington University, 969 Mason Rd, Suite 200, St Louis, MO Financial Disclosure: None. REFERENCES 1. Muller SA, Winkelmann RK. Necrobiosis lipoidica diabeticorum. Arch Dermatol. 1966;93: Goldstein BG, Goldstein AO. Practical Dermatology. St Louis, Mo: Mosby Year Book Inc; Lowitt MH, Dover JS. Necrobiosis lipoidica. J Am Acad Dermatol. 1991;25: Dahl MV. Immunofluorescence, necrobiosis lipoidica, and blood vessels. Arch Dermatol. 1988;124: Perri AJ III, Hsu S. A review of thalidomide s history and current dermatological applications. Dermatol Online J. 2003;9:5. 6. Franks ME, Macpherson GR, Figg WD. Thalidomide. Lancet. 2004;363: Laffitte E, Revuz J. Thalidomide: an old drug with new clinical applications. Expert Opin Drug Saf. 2004;3: Lagueny A, Rommel A, Vignolly B, et al. Thalidomide neuropathy: an electrophysiologic study. Muscle Nerve. 1986;9: Bastuji-Garin S, Ochonisky S, Bouche P, et al. Incidence and risk factors for thalidomide neuropathy: a prospective study of 135 dermatologic patients. J Invest Dermatol. 2002;119: Joglekar S, Levin M. The promise of thalidomide: evolving indications. Drugs Today (Barc). 2004;40: Submissions Clinicians, residents, and fellows are invited to submit cases of challenges in management and therapeutics to this section. Cases should follow the established pattern. Manuscripts should be prepared double-spaced with right margins nonjustified. Pages should be numbered consecutively with the title page separated from the text (see Instructions for Authors for information about preparation of the title page). Clinical photographs, photomicrographs, and illustrations must be sharply focused and submitted as separate JPG files with each file numbered with the manuscript number (eg, Fig 1_DCE00001.jpg). Material must be accompanied by the required copyright transfer statement (see Instructions for Authors). Preliminary inquiries regarding submissions for this feature may be submitted to George J. Hruza, MD (ghruza@aol.com). Manuscripts should be submitted electronically to archdermatol@jama-archives.org. Please indicate in your that the manuscript is a submission to Cutting Edge. Correction Error in Byline. In the Evidence-Based Dermatology Study by Charman et al titled Measuring Atopic Eczema Severity Visually: Which Variables Are Most Important to Patients? published in the September issue of the ARCHIVES (2005;141: ), Michael Bigby, MD, was mistakenly added to the byline. (REPRINTED) ARCH DERMATOL/ VOL 142, JAN American Medical Association. All rights reserved.
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