HIV MEDICATIONS AT A GLANCE. Atripla 600/200/300 mg tablet tablet daily. Complera 200/25/300 mg tablet tablet daily

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Patience Sullivan
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HIV MEDICATIONS AT A GLANCE Generic Name Trade Name Strength

Efavirenz/ Emtricitabine/ rilpivirine/ elvitegravir/

elvitegravir/ cobicistat/ abacavir/ dolutegravir/ CCR5

200/25/300 mg 02374129 1 daily Genvoya 150/150 mg/200/10 mg

1 daily Stribild Triumeq 150/150 mg/200/300 mg abacavir 600mg,

maraviroc Celsentri (US: Selzentry) 150 mg and 300 mg 02299844

dolutegravir Tivicay 50 mg 02414945 50 mg daily (naïve) or BID

mg) raltegravir Isentress 400 mg raltegravir/ NRTIs:

02301881 Dutrebis 300 mg/150 mg Licensed but not commercially

1 HIV MEDICATIONS AT A GLANCE Generic Name Trade Name Strength DIN Usual Dosage Single Tablet Regimen (STR) Products Efavirenz/ Emtricitabine/ rilpivirine/ elvitegravir/ cobicistat/ alafenamide Emtricitabine/ rilpivirine/ alafenamide elvitegravir/ cobicistat/ abacavir/ dolutegravir/ CCR5 Inhibitor Atripla 600/200/300 mg daily Complera 200/25/300 mg daily Genvoya 150/150 mg/200/10 mg daily Odefsey 200/25/25 mg Available in the U.S. 1 daily Stribild Triumeq 150/150 mg/200/300 mg abacavir 600mg, dolutegravir 50mg and 300mg daily daily maraviroc Celsentri (US: Selzentry) 150 mg and 300 mg (150 mg) (300 mg) Integrase Inhibitor dolutegravir Tivicay 50 mg mg daily (naïve) or BID (experienced) elvitegravir Vitekta 85 and 150 mg (85 mg) raltegravir Isentress 400 mg raltegravir/ NRTIs: Combination Products 100 mg, 25 mg chewable (150 mg) Dutrebis 300 mg/150 mg Licensed but not commercially available in U.S mg daily based on weight (pediatric) Abacavir, Kivexa (US: Epzicom) 600/300 mg daily

2 Tenofovir disoproxil, emtricitabine Tenofovir alafenamide, emtrictabine zidovudine/ zidovudine/ / abacavir Truvada 300/200 mg daily Descovy Combivir Lamivudine- Zidovudine 25/200 mg 10/200 mg 300 mg/150 mg daily 1 BID Trizivir 300/150/300 mg BID NRTIs (nucleos(t)ide reverse transcriptase inhibitors) abacavir Ziagen 300 mg or 600 mg QD AZT, zidovudine Retrovir 300 mg (100 mg) 300, or 200 mg TID 3TC, Zidovudine Novo-AZT TC 150, 300 mg (150 mg) (300 mg) Lamivudine 150, 300 mg (150 mg) (300 mg) 150 or 300 mg QD ddi, didanosine Videx 2g, 4 g bottles pediatric powder for oral solution ddi, didanosine Videx EC 125, 200, 250, 400 mg enteric coated capsules (4g) 400 mg daily, or (125 mg) (200 mg) (250 mg) (400 mg) d4t, stavudine Zerit 15, 20, 30, 40 mg capsule (30 mg); (40 mg) 400 mg daily FTC, Emtricitabine Emtriva 200 mg capsule 10 mg/ml oral solution Viread 300 mg 150, 200, 250 mg 40 mg/1g oral powder NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitors) delavirdine Rescriptor 100 mg (200 mg in U.S.) ; Available in U.S. 200 mg once a day 300 mg once daily mg TID

) nevirapine Viramune Auro- Nevirapine Viramune XR 200 mg 200 mg (generic) 400 mg 02306778 (100 mg), 02375931 (200 mg) 02238748 02318601 02367289 200 200 mg daily x 14 days, then 200 mg BID 400 mg QD

3 efavirenz Sustiva 200, 100, 50 mg capsule, 600 mg (50 mg), (100 mg), (200 mg), (600 mg) 600 mg daily etravirine Intelence 100, 200 mg (25 mg in U.S.) nevirapine Viramune Auro- Nevirapine Viramune XR 200 mg 200 mg (generic) 400 mg (100 mg), (200 mg) mg daily x 14 days, then 200 mg BID 400 mg QD rilpivirine Edurant 25 mg mg QD Protease Inhibitors atazanavir Reyataz 150, 200, 300 mg capsule (150 mg); (200 mg); (300 mg) atazanavir/ cobicistat 400 mg QD, or 300 mg with 100 mg ritonavir QD Evotaz 300 mg/150 mg daily darunavir Prezista 75, 150, 400, 600, 800 mg darunavir/ cobicistat fosamprenavir (100 mg/ml oral suspension in U.S.) (75 mg); (150 mg); (400 mg); (600 mg); (800 mg) 600 mg plus 100 mg ritonavir BID or 800/100 mg QD for naive subjects Prezcobix 800 mg/150 mg daily Telzir (US: Lexiva) 700 mg 50 mg/ml oral suspension (700 mg), (susp) indinavir Crixivan 200, 400 mg capsules (200 mg); (400 mg) 700 mg plus 100 mg ritonavir BID, or 1400 mg plus mg ritonavir QD 800 mg q8h lopinavir/ ritonavir Kaletra 200/50 mg 100/25 mg 80mg/20 mg per ml solution /100 or 800/200 mg QD (naïve subjects) nelfinavir Viracept 250 mg (blue), 625 mg (white) (250 mg); (625 mg) 1250 or 750 mg TID ritonavir Norvir 100 mg 80 mg/ml solution saquinavir Invirase 200 mg hard gel capsule 500 mg film-coated mg QD/BID as booster 1000 mg/100 mg rtv BID

tipranavir Aptivus 250 mg capsule 02273322 500 mg/200 mg ritonavir BID Fusion Inhibitor enfuvirtide Fuzeon 108 mg/vial (powder for injection) 02247725

4 tipranavir Aptivus 250 mg capsule mg/200 mg ritonavir BID Fusion Inhibitor enfuvirtide Fuzeon 108 mg/vial (powder for injection) mg SC BID Pharmacokinetic Enhancer cobicistat Tybost 150 mg mg daily A. Tseng, Pharm.D., FCSHP, AAHIVP, Toronto General Hospital May 2016

DISCONTINUED HIV MEDICATIONS Generic Name Trade Name Strength DIN Usual Dosage NRTIs (nucleoside reverse transcriptase inhibitors) ddi, didanosine Videx 25, 50, 100, 150 mg ddc, zalcitabine 01940546

5 DISCONTINUED HIV MEDICATIONS Generic Name Trade Name Strength DIN Usual Dosage NRTIs (nucleoside reverse transcriptase inhibitors) ddi, didanosine Videx 25, 50, 100, 150 mg ddc, zalcitabine (100 mg) (150 mg) D/C February 2006 Hivid 0.75 mg (0.75 mg) D/C February 28, mg daily, or mg TID Protease Inhibitors amprenavir Agenerase 50, 150 mg capsule (50 mg), (150 mg) D/C December darunavir Prezista 300 mg Replaced by 600 mg nelfinavir Viracept Oral powder 50mg/g (1g= level scoopful) (D/C 2006) saquinavir Fortovase 200 mg soft gel capsule lopinavir/ ritonavir (D/C 2006) Kaletra 133mg/33 mg capsule (d/c July 11, 2008) 1200 mg TID or /100 or 800/200 mg QD (naïve subjects)

HIV Drugs and the HIV Lifecycle

HIV Drugs and the HIV Lifecycle Together, we can change the course of the HIV epidemic one woman at a time. #onewomanatatime #thewellproject All HIV drugs work by interrupting different steps in HIV's