DT Description Price Category Price change Percentage BNF 1.2 Mebeverine 135mg tablets (100) 702 M %

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1 December 16 No Category M changes so the reductions imposed in May which were only supposed to last until September continue As in November, most changes are Category A lines with a few Category C. Significant price decreases: Again, just one and again, it's aripiprazole where 28x30mg tablets drop a further 15% (503p) to Remember orodispersible 10 and 15mg tablets are almost 50x more expensive than plain release. Significant price increases: What were Predfoam enemas are up 70% to for 14 Three in Chapter 13: -What was Dermovate-NN cream and ointment up 18% to (30g) -All strengths of tacrolimus ointment up 20% so e.g. 30g x 0.03% now Zineryt also up 20% e.g. 30ml now 9.25 Pilocarpine eye drops up again. November 16 No Category M changes as expected but we'll see if any come in next month with the new Community Pharmacy funding arrangements. Thus nearly all changes are Category A lines although a few Category C ones too. Significant price decreases: Just one! (there are others but they're not large volume lines) Aripiprazole 30mg tablets down 17% to (28) Significant price increases: Lithium carbonate 250mg tablets (100) up 81% to 87 The other notable increases are Category C lines so based on brands: Flixotide Accuhalers up 20% Ventolin Accuhaler up 20% Tamsulosin 400microgram / Dutasteride 500microgram capsules (30) i.e. Combodart also up 20% (to 23.76) And most strengths of pilocarpine eye drops now cost more than 10. October 2016 Despite a new quarter, Category M changes are generally slight. Although October is the usual month for major changes to the Community Pharmacy Contract, an announcement is due in the middle of the month to take effect from December 2016 In the meantime, the overall impact of this month's Category M changes seem to be a slight overall reduction. Significant price decreases: Frovatriptan 2.5mg tablets change from Category A to M with a 29% reduction. Rasagiline 1mg tablets make the same move with a 66% reduction. Significant price increases: Isosorbide mononitrate tablets rise 2-3 fold. Alfacalcidol capsules move from Category M to A with price rises. The addition of further generic descriptions into Part VIII is welcomed. DT Description Price Category Price change Percentage BNF 1.2 Mebeverine 135mg tablets (100) 702 M % 1.3 Esomeprazole 20mg gastro-resistant tablets (28) 297 M % Esomeprazole 40mg gastro-resistant tablets (28) 354 M % Lansoprazole 15mg gastro-resistant capsules (28) 94 M unchanged Lansoprazole 15mg orodispersible tablets (28) 232 M unchanged Lansoprazole 30mg gastro-resistant capsules (28) 126 M 3 2.4% Lansoprazole 30mg orodispersible tablets (28) 400 M %

2 Omeprazole 10mg gastro-resistant capsules (28) 90 M % Omeprazole 10mg gastro-resistant tablets (28) 790 A unchanged Omeprazole 20mg gastro-resistant capsules (28) 91 M % Omeprazole 20mg gastro-resistant tablets (28) 596 M % Omeprazole 40mg gastro-resistant capsules (7) 75 M % Omeprazole 40mg gastro-resistant tablets (7) 598 M % Pantoprazole 20mg gastro-resistant tablets (28) 99 M 2 2.1% Pantoprazole 40mg gastro-resistant tablets (28) 116 M unchanged Rabeprazole 10mg gastro-resistant tablets (28) 157 M % Rabeprazole 20mg gastro-resistant tablets (28) 192 M 2 1.1% Ranitidine 150mg tablets (60) 131 M 4 3.1% Ranitidine 300mg tablets (30) 129 M 2 1.6% Ranitidine 75mg/5ml oral solution sugar free (300ml) 645 M % 1.6 Macrogol compound oral powder sachets NPF sugar free (30) 427 C unchanged Senna 7.5mg tablets (60) 298 M % Chapter Bendroflumethiazide 2.5mg tablets (28) 67 M % Bendroflumethiazide 5mg tablets (28) 87 M % Bumetanide 1mg tablets (28) 143 M 6 4.4% Bumetanide 5mg tablets (28) 698 A unchanged Eplerenone 25mg tablets (28) 606 M % Eplerenone 50mg tablets (28) 721 M % Furosemide 40mg tablets (28) 74 M 3 4.2% Indapamide 2.5mg tablets (28) 130 M 1 0.8% 2.4 Atenolol 50mg tablets (28) 83 M % Atenolol 100mg tablets (28) 79 M 6 8.2% Bisoprolol 5mg tablets (28) 76 M unchanged Bisoprolol 10mg tablets (28) 80 M unchanged Carvedilol 12.5mg tablets (28) 96 M unchanged Carvedilol 25mg tablets (28) 119 M 3 2.6% Nebivolol 2.5mg tablets (28) 3218 M % Nebivolol 5mg tablets (28) 140 M 8 6.1% Doxazosin 4mg tablets (28) 83 M 2 2.5% Enalapril 10mg tablets (28) 99 M unchanged Enalapril 20mg tablets (28) 140 M % Lisinopril 10mg tablets (28) 78 M unchanged Lisinopril 20mg tablets (28) 85 M 1 1.2% Perindopril erbumine 2mg tablets (30) 103 M % Perindopril erbumine 4mg tablets (30) 130 M 5 4.0% Perindopril erbumine 8mg tablets (30) 160 M % Ramipril 5mg capsules (28) 126 M % Ramipril 5mg tablets (28) 95 M % Ramipril 10mg capsules (28) 129 M % Ramipril 10mg tablets (28) 106 M % Candesartan 4mg tablets (7) 67 M unchanged Candesartan 8mg tablets (28) 107 M unchanged Candesartan 16mg tablets (28) 128 M % Candesartan 32mg tablets (28) 182 M 5 2.8% Irbesartan 75mg tablets (28) 97 M % Irbesartan 150mg tablets (28) 128 M % Irbesartan 300mg tablets (28) 177 M % Irbesartan 300mg / Hydrochlorothiazide 12.5mg tablets (28) 200 M % Irbesartan 300mg / Hydrochlorothiazide 25mg tablets (28) 665 A % Losartan 12.5mg tablets (28) 2666 A unchanged Losartan 25mg tablets (28) 81 M unchanged

3 Losartan 50mg tablets (28) 87 M unchanged Losartan 100mg tablets (28) 104 M unchanged Losartan 50mg / Hydrochlorothiazide 12.5mg tablets (28) 135 M 3 2.3% Losartan 100mg / Hydrochlorothiazide 25mg tablets (28) 163 M 7 4.5% Telmisartan 20mg tablets (28) 108 M 2 1.9% Telmisartan 40mg tablets (28) 128 M % Telmisartan 80mg tablets (28) 160 M % Valsartan 80mg capsules (28) 175 M % Valsartan 160mg capsules (28) 141 M % Valsartan 320mg tablets (28) 1365 A % Valsartan 160mg / Hydrochlorothiazide 12.5mg tablets (28) 242 M % Valsartan 160mg / Hydrochlorothiazide 25mg tablets (28) 1066 A % 2.6 Amlodipine 5mg tablets (28) 73 M unchanged Amlodipine 10mg tablets (28) 78 M 1 1.3% Glyceryl trinitrate 400micrograms/dose pump sublingual spray (180dose) 179 M unchanged Glyceryl trinitrate 400micrograms/dose pump sublingual spray (200dose) 182 M % Isosorbide mononitrate 10mg tablets (56) 697 M % Isosorbide mononitrate 20mg tablets (56) 328 M % Isosorbide mononitrate 40mg tablets (56) 601 M % Naftidrofuryl 100mg capsules (84) 438 M % 2.8 Warfarin 1mg tablets (28) 76 M 2 2.7% Warfarin 3mg tablets (28) 79 M 1 1.3% Warfarin 5mg tablets (28) 83 M 1 1.2% 2.9 Aspirin 75mg dispersible tablets (28) 73 M 4 5.8% Aspirin 75mg gastro-resistant tablets (28) 94 M % Clopidogrel 75mg tablets (28) 144 M % 2.12 Atorvastatin 10mg tablets (28) 89 M % Atorvastatin 20mg tablets (28) 104 M % Atorvastatin 40mg tablets (28) 124 M % Atorvastatin 80mg tablets (28) 203 M % Pravastatin 40mg tablets (28) 137 M 1 0.7% Simvastatin 10mg tablets (28) 67 M unchanged Simvastatin 20mg tablets (28) 76 M 1 1.3% Simvastatin 40mg tablets (28) 84 M unchanged Simvastatin 80mg tablets (28) 168 M % Chapter Montelukast 4mg chewable tablets sugar free (28) 135 M % Montelukast 4mg granules sachets sugar free (28) 416 M 5 1.2% Montelukast 5mg chewable tablets sugar free (28) 165 M % Montelukast 10mg tablets (28) 190 M 9 5.0% 3.4 Cetirizine 10mg tablets (30) 83 M % Desloratadine 5mg tablets (30) 96 M % Loratadine 10mg tablets (30) 87 M 1 1.2% Chapter Temazepam 10mg tablets (28) 232 M % Temazepam 20mg tablets (28) 232 M % Temazepam 10mg/5ml oral solution sugar free (300ml) A % 4.2 Aripiprazole 5mg tablets (28) 172 M % Aripiprazole 10mg tablets (28) 170 M % Aripiprazole 15mg tablets (28) 172 M % Aripiprazole 30mg tablets (28) 4151 A %

4 Olanzapine 10mg orodispersible tablets sugar free (28) 232 A % Olanzapine 10mg tablets (28) 109 M % Olanzapine 15mg orodispersible tablets sugar free (28) 284 A % Olanzapine 15mg tablets (28) 127 M % Olanzapine 20mg orodispersible tablets sugar free (28) 413 A % Olanzapine 20mg tablets (28) 155 M 8 5.4% Quetiapine 100mg tablets (60) 150 M % Quetiapine 150mg tablets (60) 209 M % Quetiapine 200mg tablets (60) 235 M 3 1.3% Quetiapine 300mg tablets (60) 306 M % Risperidone 3mg tablets (60) 154 M % Risperidone 3mg orodispersible tablets sugar free (28) 3350 A unchanged Risperidone 4mg tablets (60) 199 M 2 1.0% Risperidone 4mg orodispersible tablets sugar free (28) 3795 A unchanged Risperidone 6mg tablets (28) 358 A % 4.3 Citalopram 20mg tablets (28) 86 M 3 3.6% Citalopram 40mg tablets (28) 90 M % Duloxetine 30mg gastro-resistant capsules (28) 290 M % Duloxetine 60mg gastro-resistant capsules (28) 334 M % Escitalopram 10mg tablets (28) 147 M % Escitalopram 20mg tablets (28) 166 M % Fluoxetine 20mg capsules (30) 94 M 1 1.1% Fluoxetine 20mg/5ml oral solution (70ml) 296 M % Fluoxetine 60mg capsules (30) 899 M % Mirtazapine 30mg orodispersible tablets (30) 146 M unchanged Mirtazapine 30mg tablets (28) 124 M 5 4.2% Mirtazapine 45mg orodispersible tablets (30) 200 M % Mirtazapine 45mg tablets (28) 150 M unchanged Nortriptyline 10mg tablets (100) 3930 M % Nortriptyline 25mg tablets (100) 4144 M % Sertraline 50mg tablets (28) 123 M % Sertraline 100mg tablets (28) 138 M % 4.5 Orlistat 120mg capsules (84) 1844 M % 4.6 Ondansetron 4mg tablets (10) 119 M 3 2.6% Ondansetron 8mg tablets (10) 227 M % Co-codamol 8mg/500mg capsules (100) 1356 M % Co-codamol 8mg/500mg effervescent tablets (100) 741 M % Co-codamol 8mg/500mg tablets (100) 303 M unchanged Co-codamol 30mg/500mg capsules (100) 350 M % Co-codamol 30mg/500mg effervescent tablets (100) 878 M % Co-codamol 30mg/500mg tablets (100) 403 M 3 0.8% Paracetamol 500mg capsules (100) 284 M % Paracetamol 500mg soluble tablets (100) 742 M % Paracetamol 500mg tablets (100) 228 M % Frovatriptan 2.5mg tablets (6) 1160 A to M % Naratriptan 2.5mg tablets (6) 203 M % Rizatriptan 10mg tablets (3) 140 M % Sumatriptan 50mg tablets (6) 128 M 6 4.9% Sumatriptan 100mg tablets (6) 146 M % Zolmitriptan 2.5mg orodispersible tablets sugar free (6) 142 M 9 6.8% Zolmitriptan 2.5mg tablets (6) 138 M % 4.8 Gabapentin 300mg capsules (100) 291 M % Gabapentin 400mg capsules (100) 444 M % Gabapentin 600mg tablets (100) 850 M % Gabapentin 800mg tablets (100) 2847 A 2 0.1%

5 Lamotrigine 100mg dispersible tablets sugar free (56) 448 M % Lamotrigine 100mg tablets (56) 184 M % Lamotrigine 200mg tablets (56) 245 M 4 1.7% Levetiracetam 250mg tablets (60) 210 M % Levetiracetam 500mg tablets (60) 276 M % Levetiracetam 750mg tablets (60) 402 M % Levetiracetam 1g tablets (60) 561 M % Topiramate 25mg capsules (60) 1463 M 8 0.5% Topiramate 25mg tablets (60) 185 M % Topiramate 50mg capsules (60) 5584 A % Topiramate 50mg tablets (60) 209 M 8 4.0% Topiramate 100mg tablets (60) 274 M 5 1.9% Topiramate 200mg tablets (60) 1400 A % 4.9 Entacapone 200mg tablets (30) 580 M % Rasagiline 1mg tablets (28) 1338 A to M % Riluzole 50mg tablets (56) 1626 M % 4.11 Donepezil 5mg tablets (28) 104 M % Donepezil 10mg tablets (28) 154 M % Memantine 10mg tablets (28) 136 M 1 0.7% Memantine 20mg tablets (28) 150 M % Rivastigmine 3mg capsules (28) 285 M unchanged Rivastigmine 4.5mg capsules (28) 1437 A % Rivastigmine 6mg capsules (28) 1680 A % Rivastigmine 9.5mg/24hours transdermal patches (30) 3030 A % Chapter Amoxicillin 250mg capsules (21) 108 M 7 6.9% Amoxicillin 500mg capsules (21) 126 M % Clarithromycin 250mg tablets (14) 135 M % Clarithromycin 500mg tablets (14) 221 M % Co-amoxiclav 250mg/125mg tablets (21) 203 M % Erythromycin 250mg gastro-resistant tablets (28) 133 M % Flucloxacillin 125mg/5ml oral solution (100ml) 560 M % Flucloxacillin 125mg/5ml oral solution sugar free (100ml) 2197 M % Flucloxacillin 250mg capsules (28) 135 M 5 3.8% Flucloxacillin 250mg/5ml oral solution sugar free (100ml) 2648 M % Flucloxacillin 500mg capsules (28) 214 M % Metronidazole 200mg tablets (21) 212 M % Metronidazole 400mg tablets (21) 147 M % Nitrofurantoin 50mg tablets (28) 1062 M % Nitrofurantoin 100mg tablets (28) 416 M % Oxytetracycline 250mg tablets (28) 129 M % Phenoxymethylpenicillin 250mg tablets (28) 104 M % Tetracycline 250mg tablets (28) 205 M 7 3.5% Trimethoprim 200mg tablets (14) 73 M % 5.2 Terbinafine 250mg tablets (14) 118 M % 5.3 Aciclovir 400mg tablets (56) 302 M % Aciclovir 800mg dispersible tablets (35) 1098 A 1 0.1% Aciclovir 800mg tablets (35) 332 M 6 1.8% Famciclovir 250mg tablets (21) A 8 0.1% Famciclovir 500mg tablets (14) A % Valaciclovir 500mg tablets (10) 318 M % Chapter Metformin 500mg tablets (28) 86 M unchanged Metformin 500mg/5ml oral solution sugar free (150ml) 1565 M % Metformin 850mg tablets (56) 120 M %

6 Gliclazide 80mg tablets (28) 87 M 3 3.6% Glimepiride 2mg tablets (30) 96 M 5 5.5% Glimepiride 3mg tablets (30) 100 M 6 6.4% Glimepiride 4mg tablets (30) 97 M % Pioglitazone 15mg tablets (28) 823 M % Pioglitazone 30mg tablets (28) 1089 M % Pioglitazone 45mg tablets (28) 1171 M % 6.2 Carbimazole 5mg tablets (100) 6812 M % Carbimazole 20mg tablets (100) M % Levothyroxine sodium 25microgram tablets (28) 285 M % Levothyroxine sodium 50microgram tablets (28) 165 M % Levothyroxine sodium 100microgram tablets (28) 165 M % 6.3 Hydrocortisone 10mg tablets (30) 7440 M % Hydrocortisone 20mg tablets (30) A % Prednisolone 2.5mg gastro-resistant tablets (28) 120 M % Prednisolone 5mg gastro-resistant tablets (28) 121 M % Prednisolone 5mg tablets (28) 87 M 1 1.2% 6.4 Finasteride 5mg tablets (28) 112 M unchanged Raloxifene 60mg tablets (28) 377 M 4 1.1% 6.5 Desmopressin 100microgram tablets (90) 6307 A 1 0.0% Desmopressin 10micrograms/dose nasal spray (60dose) 2316 M % Desmopressin 200microgram tablets (30) 741 M % 6.6 Alendronic acid 10mg tablets (28) 176 M % Alendronic acid 70mg tablets (4) 78 M 1 1.3% Ibandronic acid 50mg tablets (28) 627 M % Ibandronic acid 150mg tablets (1) 110 M % Risedronate sodium 35mg tablets (4) 89 M 2 2.3% Chapter 7 Desogestrel 75microgram tablets (84) 193 M 2 1.0% Duloxetine 20mg gastro-resistant capsules (28) 399 M % Duloxetine 40mg gastro-resistant capsules (56) 661 M % Oxybutynin 2.5mg tablets (56) 125 M % Oxybutynin 5mg tablets (56) 170 M % Sildenafil 25mg tablets (4) 82 M % Sildenafil 50mg tablets (4) 86 M % Sildenafil 100mg tablets (4) 98 M 3 3.2% Tolterodine 1mg tablets (56) 191 M % Tolterodine 2mg tablets (56) 208 M 7 3.5% Trospium chloride 20mg tablets (60) 580 M % Chapter 8 Anastrozole 1mg tablets (28) 119 M % Azathioprine 25mg tablets (28) 201 M 1 0.5% Azathioprine 50mg tablets (56) 221 M % Bicalutamide 50mg tablets (28) 189 M 6 3.3% Bicalutamide 150mg tablets (28) 436 M 3 0.7% Exemestane 25mg tablets (30) 575 M % Letrozole 2.5mg tablets (14) 132 M % Mycophenolate mofetil 500mg tablets (50) 664 M % Tamoxifen 20mg tablets (30) 273 M % Tamoxifen 40mg tablets (30) 3343 A 8 0.2% Chapter 9 Alfacalcidol 250nanogram capsules (30) 230 M to A % Alfacalcidol 500nanogram capsules (30) 518 M to A % Alfacalcidol 1microgram capsules (30) 640 M to A %

7 Hydroxocobalamin 1mg/1ml solution for injection ampoules (5) 711 M % Sevelamer 800mg tablets (180) 7411 M % Sodium bicarbonate 500mg capsules (56) 222 M % Chapter 10 Celecoxib 100mg capsules (60) 225 M % Celecoxib 200mg capsules (30) 198 M 6 3.1% Diclofenac sodium 25mg gastro-resistant tablets (28) 247 M % Diclofenac sodium 50mg gastro-resistant tablets (28) 329 M 2 0.6% Diclofenac sodium 75mg modified-release tablets (56) 1131 C % Diclofenac sodium 100mg modified-release tablets (28) 810 C % Ibuprofen 400mg tablets (84) 312 M % Ibuprofen 600mg tablets (84) 577 M % Ibuprofen 5% gel (100g) 462 A unchanged Ketoprofen 2.5% gel (100g) 328 M % Leflunomide 10mg tablets (30) 470 M % Leflunomide 20mg tablets (30) 459 M % Naproxen 500mg gastro-resistant tablets (56) 734 M % Naproxen 500mg tablets (28) 142 M % Piroxicam 0.5% gel (112g) 517 M % Chapter Chloramphenicol 0.5% eye drops (10ml) 182 M % Chloramphenicol 1% eye ointment (4g) 193 M % Fusidic acid 1% modified-release eye drops (5g) 2906 C unchanged 11.4 Sodium cromoglicate 2% eye drops (13.5ml) 172 M % 11.6 Brimonidine 0.2% eye drops (5ml) 168 M % Brinzolamide 10mg/ml eye drops (5ml) 224 M % Dorzolamide 2% / Timolol 0.5% eye drops (5ml) 194 M 2 1.0% Dorzolamide 2% eye drops (5ml) 196 M % Latanoprost 50micrograms/ml / Timolol 5mg/ml eye drops (2.5ml) 273 M % Latanoprost 50micrograms/ml eye drops (2.5ml) 148 M % Timolol 0.25% eye drops (5ml) 107 M 4 3.9% Timolol 0.5% eye drops (5ml) 101 M % 11.8 Hypromellose 0.3% eye drops (10ml) 121 M % Chapter 12 Beclometasone 50micrograms/dose nasal spray (200dose) 193 M % Budesonide 64micrograms/dose nasal spray (120dose) 477 A unchanged Ipratropium bromide 21micrograms/dose nasal spray (180dose) 654 C unchanged Mometasone 50micrograms/dose nasal spray (140dose) 231 M 8 3.6% Nystatin 100,000units/ml oral suspension (30ml) 209 M % Chapter Betamethasone valerate 0.1% cream (30g) 333 M 9 2.8% Betamethasone valerate 0.1% ointment (30g) 244 M 5 2.1% Hydrocortisone 1% cream (30g) 188 M 6 3.3% Hydrocortisone 1% ointment (30g) 226 M % Hydrocortisone 2.5% cream (15g) 568 M % Mometasone 0.1% cream (30g) 187 M % Mometasone 0.1% ointment (30g) 177 M % 13.6 Co-cyprindiol 2000microgram/35microgram tablets (63) 570 A 1 0.2% Aciclovir 5% cream (2g) 109 M 1 0.9% Amorolfine 5% medicated nail lacquer (5ml) 777 M % Aqueous cream (500g) 455 M %

8 Terbinafine 1% cream (30g) 256 M % Other sizes of tubes of creams / ointments available; prices in direct proportion to those listed above. September 2016 Again, no Category M changes at all this month as would be expected "mid-quarter". Despite continuing upward drift of many Category A prices, the overall impact is very small. Price decreases: Continuing the recent trend, the price of aripiprazole 30mg tablets falls, this time by 21% to (28) Rivastigmine 9.5mg/24hour patches are down 11% to Price increases: Otrivine eye drops are up 43% to 3.35 Some price rises for Concordia lines are noted: Dicycloverine tablets up 16% to and for 28x10mg and 28x20mg respectively 90 Nefopam 30mg tablets up 4% to Trimipramine 50mg capsules up 27% to 190 (28) Trimipramine 10mg and 25mg tablets up 16% to and respectively (28) The addition of more generic descriptions into Part VIII is welcomed. August 2016 No Category M changes at all this month so some mid-quarter stability and a return to "normality". Nevertheless, the general upward drift of many Category A prices continues. Most notable price increase is the 29% rise in the price of rivastigmine patches to for 30. The most significant decrease is the 14% reduction in the price of aripiprazole 30mg tablets to for 28 Overall budgetary impact is slight. The addition of a number of generic descriptions to Part VIII will further reduce the potential for inflated non-part VIII charges. July 2016 Further Category M changes (both decreases and increases) and a few more limes worth reporting this month so another report. Price changes are in comparison to June. Some chapter classification errors and other bits from June also corrected / tidied up. Overall there appears to be a further small saving on June. DT Description Price Category Price change Percentage BNF 1.2 Mebeverine 135mg tablets (100) 688 M % 1.3 Esomeprazole 20mg gastro-resistant tablets (28) 310 M % Esomeprazole 40mg gastro-resistant tablets (28) 377 M % Lansoprazole 15mg gastro-resistant capsules (28) 94 M % Lansoprazole 15mg orodispersible tablets (28) 232 M % Lansoprazole 30mg gastro-resistant capsules (28) 123 M % Lansoprazole 30mg orodispersible tablets (28) 418 M unchanged Omeprazole 10mg gastro-resistant capsules (28) 92 M unchanged Omeprazole 10mg gastro-resistant tablets (28) 790 A unchanged Omeprazole 20mg gastro-resistant capsules (28) 91 M % Omeprazole 20mg gastro-resistant tablets (28) 605 M % Omeprazole 40mg gastro-resistant capsules (7) 78 M unchanged Omeprazole 40mg gastro-resistant tablets (7) 609 M % Pantoprazole 20mg gastro-resistant tablets (28) 97 M 1 1.0% Pantoprazole 40mg gastro-resistant tablets (28) 116 M 1 0.9% Rabeprazole 10mg gastro-resistant tablets (28) 160 M % Rabeprazole 20mg gastro-resistant tablets (28) 190 M 3 1.6% Ranitidine 150mg tablets (60) 127 M % Ranitidine 300mg tablets (30) 127 M % Ranitidine 75mg/5ml oral solution sugar free (300ml) 646 M 1 0.2% 1.6 Macrogol compound oral powder sachets NPF sugar free (30) 427 C unchanged Senna 7.5mg tablets (60) 299 M % Chapter 2 2.2

9 Bendroflumethiazide 2.5mg tablets (28) 68 M 1 1.5% Bendroflumethiazide 5mg tablets (28) 89 M % Bumetanide 1mg tablets (28) 137 M % Bumetanide 5mg tablets (28) 698 A unchanged Eplerenone 25mg tablets (28) 808 M % Eplerenone 50mg tablets (28) 870 M % Furosemide 40mg tablets (28) 71 M 1 1.4% Indapamide 2.5mg tablets (28) 129 M % 2.4 Atenolol 50mg tablets (28) 68 M % Atenolol 100mg tablets (28) 73 M unchanged Bisoprolol 5mg tablets (28) 76 M unchanged Bisoprolol 10mg tablets (28) 80 M 1 1.3% Carvedilol 12.5mg tablets (28) 96 M % Carvedilol 25mg tablets (28) 116 M 1 0.9% Nebivolol 2.5mg tablets (28) 4041 M % Nebivolol 5mg tablets (28) 132 M % Doxazosin 4mg tablets (28) 81 M unchanged Enalapril 10mg tablets (28) 99 M % Enalapril 20mg tablets (28) 144 M 2 1.4% Lisinopril 10mg tablets (28) 78 M 2 2.6% Lisinopril 20mg tablets (28) 84 M % Perindopril erbumine 2mg tablets (30) 115 M % Perindopril erbumine 4mg tablets (30) 125 M 9 7.8% Perindopril erbumine 8mg tablets (30) 141 M % Ramipril 5mg capsules (28) 106 M 9 9.3% Ramipril 5mg tablets (28) 97 M 3 3.2% Ramipril 10mg capsules (28) 113 M % Ramipril 10mg tablets (28) 109 M 5 4.8% Candesartan 4mg tablets (7) 67 M % Candesartan 8mg tablets (28) 107 M 2 1.9% Candesartan 16mg tablets (28) 130 M 4 3.2% Candesartan 32mg tablets (28) 177 M % Irbesartan 75mg tablets (28) 99 M % Irbesartan 150mg tablets (28) 130 M unchanged Irbesartan 300mg tablets (28) 180 M % Irbesartan 300mg / Hydrochlorothiazide 12.5mg tablets (28) 157 M % Irbesartan 300mg / Hydrochlorothiazide 25mg tablets (28) 643 A % Losartan 12.5mg tablets (28) 2666 A % Losartan 25mg tablets (28) 81 M % Losartan 50mg tablets (28) 87 M % Losartan 100mg tablets (28) 104 M % Losartan 50mg / Hydrochlorothiazide 12.5mg tablets (28) 132 M % Losartan 100mg / Hydrochlorothiazide 25mg tablets (28) 156 M 5 3.3% Telmisartan 20mg tablets (28) 106 M % Telmisartan 40mg tablets (28) 107 M % Telmisartan 80mg tablets (28) 137 M % Valsartan 80mg capsules (28) 88 M % Valsartan 160mg capsules (28) 89 M % Valsartan 320mg tablets (28) 1431 A % Valsartan 160mg / Hydrochlorothiazide 12.5mg tablets (28) 245 M % Valsartan 160mg / Hydrochlorothiazide 25mg tablets (28) 1081 A 4 0.4% 2.6 Amlodipine 5mg tablets (28) 73 M 1 1.4% Amlodipine 10mg tablets (28) 77 M unchanged Glyceryl trinitrate 400micrograms/dose pump sublingual spray (180dose) 179 M % Glyceryl trinitrate 400micrograms/dose pump sublingual spray (200dose) 185 M % Isosorbide mononitrate 10mg tablets (56) 150 M % Isosorbide mononitrate 20mg tablets (56) 119 M % Isosorbide mononitrate 40mg tablets (56) 172 M %

10 Naftidrofuryl 100mg capsules (84) 469 M % 2.8 Warfarin 1mg tablets (28) 74 M % Warfarin 3mg tablets (28) 78 M % Warfarin 5mg tablets (28) 82 M unchanged 2.9 Aspirin 75mg dispersible tablets (28) 69 M 1 1.5% Aspirin 75mg gastro-resistant tablets (28) 74 M 1 1.4% Clopidogrel 75mg tablets (28) 154 M 6 4.1% 2.12 Atorvastatin 10mg tablets (28) 92 M % Atorvastatin 20mg tablets (28) 109 M % Atorvastatin 40mg tablets (28) 127 M % Atorvastatin 80mg tablets (28) 211 M % Pravastatin 40mg tablets (28) 136 M % Simvastatin 10mg tablets (28) 67 M unchanged Simvastatin 20mg tablets (28) 75 M % Simvastatin 40mg tablets (28) 84 M % Simvastatin 80mg tablets (28) 182 M % Chapter Montelukast 4mg chewable tablets sugar free (28) 139 M 4 3.0% Montelukast 4mg granules sachets sugar free (28) 411 M 6 1.5% Montelukast 5mg chewable tablets sugar free (28) 169 M % Montelukast 10mg tablets (28) 181 M % 3.4 Cetirizine 10mg tablets (30) 86 M 5 6.2% Desloratadine 5mg tablets (30) 103 M % Loratadine 10mg tablets (30) 86 M unchanged Chapter Temazepam 10mg tablets (28) 278 M % Temazepam 20mg tablets (28) 272 M % Temazepam 10mg/5ml oral solution sugar free (300ml) A % 4.2 Aripiprazole 5mg tablets (28) 283 M % Aripiprazole 10mg tablets (28) 277 M % Aripiprazole 15mg tablets (28) 274 M % Aripiprazole 30mg tablets (28) 7341 A % Olanzapine 10mg orodispersible tablets sugar free (28) 237 A % Olanzapine 10mg tablets (28) 111 M % Olanzapine 15mg orodispersible tablets sugar free (28) 295 A % Olanzapine 15mg tablets (28) 132 M 1 0.8% Olanzapine 20mg orodispersible tablets sugar free (28) 441 A % Olanzapine 20mg tablets (28) 147 M % Quetiapine 100mg tablets (60) 186 M 7 3.9% Quetiapine 150mg tablets (60) 210 M % Quetiapine 200mg tablets (60) 232 M % Quetiapine 300mg tablets (60) 312 M % Risperidone 3mg tablets (60) 177 M % Risperidone 3mg orodispersible tablets sugar free (28) 3350 A unchanged Risperidone 4mg tablets (60) 197 M 3 1.5% Risperidone 4mg orodispersible tablets sugar free (28) 3795 A unchanged Risperidone 6mg tablets (28) 386 A unchanged 4.3 Citalopram 20mg tablets (28) 83 M 1 1.2% Citalopram 40mg tablets (28) 94 M % Duloxetine 30mg gastro-resistant capsules (28) 481 M % Duloxetine 60mg gastro-resistant capsules (28) 439 M %

11 Escitalopram 10mg tablets (28) 123 M 6 5.1% Escitalopram 20mg tablets (28) 126 M % Fluoxetine 20mg capsules (30) 93 M 1 1.1% Fluoxetine 20mg/5ml oral solution (70ml) 306 M % Fluoxetine 60mg capsules (30) 998 M % Mirtazapine 30mg orodispersible tablets (30) 146 M % Mirtazapine 30mg tablets (28) 119 M % Mirtazapine 45mg orodispersible tablets (30) 204 M % Mirtazapine 45mg tablets (28) 150 M % Nortriptyline 10mg tablets (100) 4756 M % Nortriptyline 25mg tablets (100) 4961 M % Sertraline 50mg tablets (28) 125 M % Sertraline 100mg tablets (28) 148 M 9 6.5% 4.5 Orlistat 120mg capsules (84) 1867 M % 4.6 Ondansetron 4mg tablets (10) 116 M % Ondansetron 8mg tablets (10) 228 M % Co-codamol 8mg/500mg capsules (100) 1122 M % Co-codamol 8mg/500mg effervescent tablets (100) 647 M % Co-codamol 8mg/500mg tablets (100) 303 M % Co-codamol 30mg/500mg capsules (100) 350 M % Co-codamol 30mg/500mg effervescent tablets (100) 781 M % Co-codamol 30mg/500mg tablets (100) 400 M % Paracetamol 500mg capsules (100) 297 M % Paracetamol 500mg soluble tablets (100) 717 M % Paracetamol 500mg tablets (100) 231 M unchanged Naratriptan 2.5mg tablets (6) 190 M 9 5.0% Rizatriptan 10mg tablets (3) 146 M % Sumatriptan 50mg tablets (6) 122 M 2 1.7% Sumatriptan 100mg tablets (6) 136 M % Zolmitriptan 2.5mg orodispersible tablets sugar free (6) 133 M % Zolmitriptan 2.5mg tablets (6) 141 M % 4.8 Gabapentin 300mg capsules (100) 307 M % Gabapentin 400mg capsules (100) 407 M % Gabapentin 600mg tablets (100) 674 M % Gabapentin 800mg tablets (100) 2841 A % Lamotrigine 100mg dispersible tablets sugar free (56) 428 M % Lamotrigine 100mg tablets (56) 163 M % Lamotrigine 200mg tablets (56) 241 M % Levetiracetam 250mg tablets (60) 213 M % Levetiracetam 500mg tablets (60) 335 M % Levetiracetam 750mg tablets (60) 425 M % Levetiracetam 1g tablets (60) 641 M % Topiramate 25mg capsules (60) 1455 M % Topiramate 25mg tablets (60) 169 M 5 3.0% Topiramate 50mg capsules (60) 5414 A % Topiramate 50mg tablets (60) 201 M % Topiramate 100mg tablets (60) 269 M 6 2.3% Topiramate 200mg tablets (60) 1402 A % 4.9 Entacapone 200mg tablets (30) 537 M % Rasagiline 1mg tablets (28) 5853 A % Riluzole 50mg tablets (56) 1881 M % 4.11 Donepezil 5mg tablets (28) 107 M % Donepezil 10mg tablets (28) 135 M %

12 Memantine 10mg tablets (28) 135 M % Memantine 20mg tablets (28) 168 M % Rivastigmine 3mg capsules (28) 285 M % Rivastigmine 4.5mg capsules (28) 1457 A % Rivastigmine 6mg capsules (28) 1558 A % Rivastigmine 9.5mg/24hours transdermal patches (30) 2496 A % Chapter Amoxicillin 250mg capsules (21) 101 M % Amoxicillin 500mg capsules (21) 127 M unchanged Clarithromycin 250mg tablets (14) 138 M % Clarithromycin 500mg tablets (14) 228 M % Co-amoxiclav 250mg/125mg tablets (21) 234 M % Erythromycin 250mg gastro-resistant tablets (28) 150 M 6 4.2% Flucloxacillin 125mg/5ml oral solution (100ml) 522 M % Flucloxacillin 125mg/5ml oral solution sugar free (100ml) 2252 M % Flucloxacillin 250mg capsules (28) 130 M 1 0.8% Flucloxacillin 250mg/5ml oral solution sugar free (100ml) 2724 M 1 0.0% Flucloxacillin 500mg capsules (28) 222 M 3 1.4% Metronidazole 200mg tablets (21) 136 M % Metronidazole 400mg tablets (21) 113 M % Nitrofurantoin 50mg tablets (28) 750 M 8 1.1% Nitrofurantoin 100mg tablets (28) 246 M % Oxytetracycline 250mg tablets (28) 90 M % Phenoxymethylpenicillin 250mg tablets (28) 92 M 1 1.1% Tetracycline 250mg tablets (28) 198 M % Trimethoprim 200mg tablets (14) 182 M % 5.2 Terbinafine 250mg tablets (14) 119 M % 5.3 Aciclovir 400mg tablets (56) 308 M % Aciclovir 800mg tablets (35) 326 M % Famciclovir 250mg tablets (21) A % Famciclovir 500mg tablets (14) A % Valaciclovir 500mg tablets (10) 291 M % Chapter Metformin 500mg tablets (28) 86 M unchanged Metformin 500mg/5ml oral solution sugar free (150ml) 1647 M % Metformin 850mg tablets (56) 132 M 2 1.5% Gliclazide 80mg tablets (28) 84 M % Glimepiride 2mg tablets (30) 91 M % Glimepiride 3mg tablets (30) 94 M 2 2.2% Glimepiride 4mg tablets (30) 112 M 6 5.7% Pioglitazone 15mg tablets (28) 1331 M % Pioglitazone 30mg tablets (28) 1481 M % Pioglitazone 45mg tablets (28) 1729 M % 6.2 Carbimazole 5mg tablets (100) 7588 M % Carbimazole 20mg tablets (100) M % Levothyroxine sodium 25microgram tablets (28) 270 M % Levothyroxine sodium 50microgram tablets (28) 172 M % Levothyroxine sodium 100microgram tablets (28) 171 M % 6.3 Hydrocortisone 10mg tablets (30) 8211 M % Hydrocortisone 20mg tablets (30) A % Prednisolone 2.5mg gastro-resistant tablets (28) 122 M % Prednisolone 5mg gastro-resistant tablets (28) 126 M % Prednisolone 5mg tablets (28) 86 M %

13 6.4 Finasteride 5mg tablets (28) 112 M % Raloxifene 60mg tablets (28) 373 M % 6.5 Desmopressin 100microgram tablets (90) 6298 A % Desmopressin 10micrograms/dose nasal spray (60dose) 2166 M % Desmopressin 200microgram tablets (30) 750 M % 6.6 Alendronic acid 10mg tablets (28) 156 M % Alendronic acid 70mg tablets (4) 77 M % Ibandronic acid 50mg tablets (28) 628 M % Ibandronic acid 150mg tablets (1) 113 M % Risedronate sodium 35mg tablets (4) 87 M % Chapter 7 Desogestrel 75microgram tablets (84) 191 M % Duloxetine 20mg gastro-resistant capsules (28) 558 M % Duloxetine 40mg gastro-resistant capsules (56) 1001 M % Oxybutynin 2.5mg tablets (56) 126 M % Oxybutynin 5mg tablets (56) 191 M unchanged Sildenafil 25mg tablets (4) 83 M unchanged Sildenafil 50mg tablets (4) 88 M % Sildenafil 100mg tablets (4) 95 M % Tolterodine 1mg tablets (56) 195 M unchanged Tolterodine 2mg tablets (56) 201 M % Trospium chloride 20mg tablets (60) 506 M % Chapter 8 Anastrozole 1mg tablets (28) 122 M % Azathioprine 25mg tablets (28) 200 M % Azathioprine 50mg tablets (56) 228 M % Bicalutamide 50mg tablets (28) 183 M % Bicalutamide 150mg tablets (28) 433 M % Exemestane 25mg tablets (30) 595 M % Letrozole 2.5mg tablets (14) 140 M % Mycophenolate mofetil 500mg tablets (50) 698 M % Tamoxifen 20mg tablets (30) 306 M % Tamoxifen 40mg tablets (30) 3285 A % Chapter 9 Alfacalcidol 250nanogram capsules (30) 124 M % Alfacalcidol 500nanogram capsules (30) 398 M 2 0.5% Alfacalcidol 1microgram capsules (30) 421 M 2 0.5% Hydroxocobalamin 1mg/1ml solution for injection ampoules (5) 728 M % Sevelamer 800mg tablets (180) 8398 M % Sodium bicarbonate 500mg capsules (56) 233 M % Chapter 10 Celecoxib 100mg capsules (60) 235 M % Celecoxib 200mg capsules (30) 192 M % Diclofenac sodium 25mg gastro-resistant tablets (28) 260 M % Diclofenac sodium 50mg gastro-resistant tablets (28) 327 M % Ibuprofen 400mg tablets (84) 315 M % Ibuprofen 600mg tablets (84) 561 M % Ibuprofen 5% gel (100g) 462 A unchanged Ketoprofen 2.5% gel (100g) 336 M 8 2.4% Leflunomide 10mg tablets (30) 585 M % Leflunomide 20mg tablets (30) 480 M % Naproxen 500mg gastro-resistant tablets (56) 754 M % Naproxen 500mg tablets (28) 124 M 2 1.6% Piroxicam 0.5% gel (112g) 549 M unchanged

14 Chapter Chloramphenicol 0.5% eye drops (10ml) 133 M % Chloramphenicol 1% eye ointment (4g) 206 M % Fusidic acid 1% modified-release eye drops (5g) 2906 C unchanged 11.4 Sodium cromoglicate 2% eye drops (13.5ml) 189 M % 11.6 Brimonidine 0.2% eye drops (5ml) 170 M % Brinzolamide 10mg/ml eye drops (5ml) 256 M % Dorzolamide 2% / Timolol 0.5% eye drops (5ml) 192 M % Dorzolamide 2% eye drops (5ml) 217 M % Latanoprost 50micrograms/ml / Timolol 5mg/ml eye drops (2.5ml) 222 M % Latanoprost 50micrograms/ml eye drops (2.5ml) 154 M % Timolol 0.25% eye drops (5ml) 103 M 1 1.0% Timolol 0.5% eye drops (5ml) 104 M unchanged 11.8 Hypromellose 0.3% eye drops (10ml) 102 M 3 3.0% Chapter 12 Beclometasone 50micrograms/dose nasal spray (200dose) 194 M % Budesonide 64micrograms/dose nasal spray (120dose) 477 A unchanged Ipratropium bromide 21micrograms/dose nasal spray (180dose) 654 C unchanged Mometasone 50micrograms/dose nasal spray (140dose) 201 M % Nystatin 100,000units/ml oral suspension (30ml) 273 M % Chapter Betamethasone valerate 0.1% cream (30g) 324 M % Betamethasone valerate 0.1% ointment (30g) 239 M % Hydrocortisone 1% cream (30g) 182 M % Hydrocortisone 1% ointment (30g) 212 M 2 1.0% Hydrocortisone 2.5% cream (15g) 523 M % Mometasone 0.1% cream (30g) 211 M 4 1.9% Mometasone 0.1% ointment (30g) 189 M % 13.6 Co-cyprindiol 2000microgram/35microgram tablets (63) 563 A 7 1.3% Aciclovir 5% cream (2g) 108 M 3 2.9% Amorolfine 5% medicated nail lacquer (5ml) 800 M % Aqueous cream (500g) 440 M % Terbinafine 1% cream (30g) 262 M unchanged Other sizes of tubes of creams / ointments available; prices in direct proportion to those listed above.

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