ANESTHESIA AND RESPIRATORY DEVICES: GLOBAL MARKETS. HLC167A February Vijay Laxmi Project Analyst ISBN:

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1 ANESTHESIA AND RESPIRATORY DEVICES: GLOBAL MARKETS HLC167A February 2014 Vijay Laxmi Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA , Custom Reports: carol.laverty@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY AND OBJECTIVE 2 TITLE DESCRIPTION 2 SCOPE OF THE REPORT 3 MARKET STRUCTURE 3 INTENDED AUDIENCE 3 RESEARCH METHODOLOGY 3 ANALYST CREDENTIALS 4 RELATED BCC RESEARCH REPORTS 4 BCC RESEARCH ONLINE SERVICES 4 DISCLAIMER 4 CHAPTER 2 EXECUTIVE SUMMARY 6 SUMMARY TABLE GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES, THROUGH 2018 ($ SUMMARY FIGURE GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES, ($ 7 7 CHAPTER 3 MARKET OVERVIEW 10 MARKET SEGMENTATION 10 FIGURE 1 SEGMENTATION OF THE ANESTHESIA DEVICES AND DRUGS MARKET 10 MARKET DYNAMICS FOR ANESTHESIA AND RESPIRATORY DEVICES 11 FIGURE 2 TECHNOLOGICAL INNOVATIONS IN ANESTHESIA AND RESPIRATORY DEVICES INCREASE IN THE NUMBER OF HOSPITALS 13 INCREASE IN THE RATE OF INCIDENCE OF COPD 13 RISING EXPENDITURE OF GOVERNMENT ON HEALTHCARE IN DEVELOPING COUNTRIES GROWING OBSTRUCTIVE SLEEP APNEA PATIENT POPULATION 14 GROWING DEMAND FOR HOME HEALTHCARE EQUIPMENT 14 REIMBURSEMENT FOR WIDE RANGE OF ANESTHESIA AND RESPIRATORY DEVICES HI-TECH SOFTWARE FOR ANESTHESIA AND RESPIRATORY MACHINES PROVIDE BETTER DELIVERY METHODS INTEGRATION OF IT WITH ANESTHESIA AND RESPIRATORY DEVICES 16 RESTRAINTS FOR THE ANESTHESIA AND RESPIRATORY DEVICES MARKET 16 COMPETITIVE PRICING BY ORIGINAL EQUIPMENT MANUFACTURER (OEM) 16 U.S. HEALTH REFORMS TO IMPACT THE MARKET FOR ANESTHESIA AND RESPIRATORY DEVICES OPPORTUNITIES FOR ANESTHESIA AND RESPIRATORY DEVICES MARKET 17 MEDICAL TOURISM 17 NEW DEVICES WITH BETTER FEATURES 18 MARKET OVERVIEW OF ANESTHESIA DRUGS 18 DRIVERS FOR ANESTHESIA DRUGS MARKET 19 Increased Life Expectancy, Therefore Increased Number of Surgeries 19 Rising Number of Emergency Surgeries 19 Growing Use of Conscious Sedation in Ambulatory Settings

3 Anesthesia-Related Treatments for Depression and Sleep Disorders 20 RESTRAINTS FOR ANESTHESIA DRUGS MARKET 20 Undertrained Nurses and Other Non-Specialists Administering Drugs in Ambulatory Settings Delays in FDA Approval of Drugs 20 OPPORTUNITIES FOR THE ANESTHESIA DRUGS MARKET 21 Growing Home Healthcare 21 New Drugs with Fewer Side Effects 21 FDA'S ROLE IN ANESTHETIC DRUGS 22 REGULATIONS AND LEGISLATION PERTAINING TO ANESTHESIA AND RESPIRATORY DEVICES UNITED STATES 22 EUROPEAN UNION 23 ASIA 24 India 25 China 26 Japan 26 ASEAN 27 Russia 28 FUTURE TRENDS 28 TECHNOLOGY AND INNOVATIONS 28 AUTOMATED SEDATION OF COLONOSCOPY SURGERY PATIENTS 28 SMARTPHONE TECHNOLOGY AND MOBILE OXIMETERS 29 INTEGRATION OF ANESTHESIA MACHINES AND CARDIAC MONITORS IN OPERATING ROOMS DISTRIBUTION NETWORK 29 HOSPITAL BUDGETARY SCENARIO 30 EUROPE 30 Scandinavia - Market Growth Based on New Hospitals 31 European Hospital Financing 31 UNITED STATES 31 Healthcare Reforms to Influence Hospitals' Purchasing Decisions Regarding Medical Devices Healthcare Reform Initiatives and Recommendations for Medical Device Manufacturers Changing Sales Models Between Hospitals and Medical Device Manufacturers ASIA 33 ISSUES AFFECTING REVENUE MODELS 33 GEOGRAPHIC ANALYSIS 34 ANALYSIS, CONCLUSIONS AND RECOMMENDATIONS 34 ANALYSIS OF THE EXPECTED EXPANSION OF THE MARKET 34 CONCLUSIONS AND RECOMMENDATIONS 35 RESEARCH AND DEVELOPMENT (R&D) INITIATIVES 35 INVESTING IN DEVELOPING ECONOMIES CHAPTER 4 PRODUCTS INCLUDED IN THE GLOBAL ANESTHESIA DEVICE MARKET 37 OVERVIEW 37 ANESTHESIA DEVICES 37

4 TABLE 1 GLOBAL ANESTHESIA DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 2 GLOBAL ANESTHESIA DEVICE MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA MACHINES 39 TABLE 3 GLOBAL ANESTHESIA MACHINE MARKET BY TYPE, THROUGH 2018 ($ TABLE 4 GLOBAL ANESTHESIA MACHINE MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA WORKSTATION 40 TABLE 5 GLOBAL ANESTHESIA WORKSTATION MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA DELIVERY MACHINES 41 TABLE 6 GLOBAL ANESTHESIA DELIVERY MACHINE MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA VENTILATORS 42 TABLE 7 GLOBAL ANESTHESIA VENTILATOR MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA MONITORS 43 TABLE 8 GLOBAL ANESTHESIA MONITOR MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA DISPOSABLES 43 TABLE 9 GLOBAL ANESTHESIA DISPOSABLES MARKET BY TYPE, THROUGH 2018 ($ ANESTHESIA MASKS 44 TABLE 10 GLOBAL ANESTHESIA MASK MARKET BY REGION, THROUGH 2018 ($ ANESTHESIA ACCESSORIES 45 TABLE 11 GLOBAL ANESTHESIA ACCESSORIES MARKET BY REGION, THROUGH 2018 ($ CHAPTER 5 GLOBAL RESPIRATORY DEVICE MARKET BY PRODUCT 47 INCREASED PATIENT PREFERENCE TOWARDS REDUCED HOSPITAL STAYS HAS PROPELLED GROWTH RISE IN INCIDENCE OF CHRONIC PULMONARY DISEASE 47 RESPIRATORY DEVICES 48 TABLE 12 GLOBAL RESPIRATORY DEVICE MARKET, THROUGH 2018 ($ 48 TABLE 13 GLOBAL RESPIRATORY DEVICE MARKET BY REGION, THROUGH 2018 ($ RESPIRATORY PRODUCTS 49 TABLE 14 GLOBAL RESPIRATORY PRODUCT MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 15 GLOBAL RESPIRATORY PRODUCT MARKET BY REGION, THROUGH 2018 ($ Respiratory Humidifiers 50 TABLE 16 GLOBAL RESPIRATORY HUMIDIFIER MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 17 GLOBAL RESPIRATORY HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ Heated Humidifiers

5 TABLE 18 GLOBAL HEATED HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ Heated Wire Breathing Circuits 51 TABLE 19 GLOBAL HEATED WIRE BREATHING CIRCUIT MARKET BY REGION, THROUGH 2018 ($ Heated Exchangers 52 TABLE 20 GLOBAL HEATED EXCHANGER MARKET BY REGION, THROUGH 2018 ($ Passover Humidifiers 52 TABLE 21 GLOBAL PASSOVER HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ Nebulizers 53 TABLE 22 GLOBAL NEBULIZER MARKET BY PRODUCT, THROUGH 2018 ($ 53 TABLE 23 GLOBAL NEBULIZER MARKET BY REGION, THROUGH 2018 ($ 54 Pneumatic Nebulizers 54 TABLE 24 GLOBAL PNEUMATIC NEBULIZER MARKET BY REGION, THROUGH 2018 ($ Intermittent Positive Pressure Breathing Nebulizers 55 TABLE 25 GLOBAL INTERMITTENT POSITIVE PRESSURE BREATHING NEBULIZER MARKET BY REGION, THROUGH 2018 ($ Ultrasonic Nebulizers 55 TABLE 26 GLOBAL ULTRASONIC NEBULIZER MARKET BY REGION, THROUGH 2018 ($ Positive Airway Pressure Devices 56 TABLE 27 GLOBAL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 28 GLOBAL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ Continuous Positive Airway Pressure Devices 57 TABLE 29 GLOBAL CONTINUOUS POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ Bilevel Positive Airway Pressure Devices 57 TABLE 30 GLOBAL BI-LEVEL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ Oxygen Concentrators 58 TABLE 31 GLOBAL OXYGEN CONCENTRATOR MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 32 GLOBAL OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ Fixed Oxygen Concentrators 59 TABLE 33 GLOBAL FIXED OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ Portable Oxygen Concentrators 59 TABLE 34 GLOBAL PORTABLE OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ Reusable Resuscitators 60 TABLE 35 GLOBAL REUSABLE RESUSCITATOR MARKET BY REGION, THROUGH 2018 ($ Ventilators 61 TABLE 36 GLOBAL VENTILATOR MARKET BY PRODUCT, THROUGH 2018 ($

6 TABLE 37 GLOBAL VENTILATOR MARKET BY REGION, THROUGH 2018 ($ 61 Adult Ventilators 62 TABLE 38 GLOBAL ADULT VENTILATOR MARKET BY REGION, THROUGH 2018 ($ Neonatal Ventilators 62 TABLE 39 GLOBAL NEONATAL VENTILATOR MARKET BY REGION, THROUGH 2018 ($ Respiratory Inhalers 63 TABLE 40 GLOBAL RESPIRATORY INHALER MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 41 GLOBAL RESPIRATORY INHALER MARKET BY REGION, THROUGH 2018 ($ Dry Powdered Inhalers 64 TABLE 42 GLOBAL DRY POWDERED INHALER MARKET BY REGION, THROUGH 2018 ($ Metered Dose Inhalers 64 TABLE 43 GLOBAL METERED DOSE INHALER MARKET BY REGION, THROUGH 2018 ($ RESPIRATORY DISPOSABLES 65 TABLE 44 GLOBAL RESPIRATORY DISPOSABLES MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 45 GLOBAL RESPIRATORY DISPOSABLES MARKET BY REGION, THROUGH 2018 ($ Disposables Oxygen Masks 66 TABLE 46 GLOBAL DISPOSABLES - OXYGEN MASK MARKET BY REGION, THROUGH 2018 ($ Resuscitators 66 TABLE 47 GLOBAL RESUSCITATOR MARKET BY REGION, THROUGH 2018 ($ Tracheostomy Tubes 67 TABLE 48 GLOBAL TRACHEOSTOMY TUBE MARKET BY REGION, THROUGH 2018 ($ Oxygen Cannula 68 TABLE 49 GLOBAL OXYGEN CANNULA MARKET BY REGION, THROUGH 2018 ($ RESPIRATORY MEASUREMENT DEVICES 68 TABLE 50 GLOBAL RESPIRATORY MEASUREMENT DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 51 GLOBAL RESPIRATORY MEASUREMENT DEVICE MARKET BY REGION, THROUGH 2018 ($ Pulse Oximeter Systems 69 TABLE 52 GLOBAL PULSE OXIMETER SYSTEM MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 53 GLOBAL PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($ Handheld Pulse Oximeter 70 TABLE 54 GLOBAL HANDHELD PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($ Table Top Pulse Oximeter 71 TABLE 55 GLOBAL TABLE TOP PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($

7 Pulse Oximeter Sensors 71 TABLE 56 GLOBAL PULSE OXIMETER SENSOR MARKET BY REGION, THROUGH 2018 ($ Capnographs 72 TABLE 57 GLOBAL CAPNOGRAPH MARKET BY REGION, THROUGH 2018 ($ Spirometers 72 TABLE 58 GLOBAL SPIROMETER MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 59 GLOBAL SPIROMETER MARKET BY REGION, THROUGH 2018 ($ 73 Mechanical Volume Spirometer 73 TABLE 60 GLOBAL MECHANICAL VOLUME SPIROMETER MARKET BY REGION, THROUGH 2018 ($ Automated Flow Spirometer 74 TABLE 61 GLOBAL AUTOMATED FLOW SPIROMETER MARKET BY REGION, THROUGH 2018 ($ Peak Flow Meters 74 TABLE 62 GLOBAL PEAK FLOW METER MARKET BY REGION, THROUGH 2018 ($ CHAPTER 6 GLOBAL ANESTHESIA DRUG MARKET BY SEGMENT 77 GENERAL ANESTHESIA 77 INHALATION ANESTHETIC DRUGS 77 INTRAVENOUS ANESTHETICS DRUGS 77 LOCAL ANESTHESIA (SPINAL AND EPIDURAL) 78 SPINAL AND EPIDURAL ANESTHESIA 78 DRUGS USED FOR SPINAL AND EPIDURAL ANESTHESIA 79 DRUGS UNDER DEVELOPMENT 80 MARKET DYNAMICS 80 MARKET SIZE AND GROWTH 80 ISSUES AND TRENDS 81 CHAPTER 7 DENTAL ANESTHESIA 83 LOCAL ANESTHESIA COMPRISES AL ANESTHESIA AND INJECTABLE LOCAL ANESTHESIA AL ANESTHETICS 84 INJECTABLE LOCAL ANESTHESIA 84 SEDATIVES 85 Minimal Sedation 85 Moderate Sedation 85 Deep Sedation 85 Inhalation Sedation 85 IV Sedation 85 ISSUES 86 PATIENT ISSUES 86 SURGICAL ISSUES 86 ADMINISTRATION OF ANESTHETIC SOLUTIONS IN DENTISTRY 86 INTRAORAL ROUTE 87 EXTRAORAL ROUTE ON CERTAIN AREAS OF THE FACE 87 83

8 MARKET DYNAMICS 87 BABY BOOMERS AT HIGHER RISK FOR TOOTH-RELATED PROBLEMS 87 COSMETIC DENTISTRY IS BECOMING POPULAR WITH THE MASSES 87 ADVANCES IN DENTAL PAIN CONTROL 88 METHOD FOR BUFFERING LOCAL ANESTHETIC SOLUTIONS 88 ADVANCES IN INSTRUMENTATION 88 NEW DRUGS 89 CONCLUSION 90 CHAPTER 8 ROUTES OF ADMINISTRATION OF ANESTHESIA 92 INHALATION 92 INTRAVENOUS 92 AL 93 CHAPTER 9 ANESTHESIA AND RESPIRATORY DEVICE MARKET BY REGION 95 INTRODUCTION 95 TABLE 63 GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES BY REGION, THROUGH 2018 ($ UNITED STATES 95 EUROPE 96 ASIA 97 CHINA 97 THE PHILIPPINES 97 INDIA 98 VIETNAM 98 ROW CHAPTER 10 THE COMPETITIVE LANDSCAPE 100 FIGURE 3 STRATEGIES FOLLOWED IN THE ANESTHETIC DEVICES AND DRUGS MARKET BY MARKET PLAYERS 2011 TO SEPTEMBER 2013 (NO.) TABLE 64 PRODUCT LAUNCHES AND APPROVALS IN MEDICAL DEVICES AND DRUGS MARKET, 2012 AND 2013 TABLE 65 MERGERS AND ACQUISITIONS IN THE MEDICAL DEVICES AND DRUGS MARKET, TABLE 66 AGREEMENT, JOINT VENTURE, DIVESTMENT AND INVESTMENT IN MEDICAL DEVICES AND DRUGS MARKET, TABLE 67 EXPANSION, REORGANIZATION AND R&D FACILITIES IN MEDICAL DEVICES & DRUGS MARKET, ($ TABLE 68 CERTIFICATION AND SERVICE IN MEDICAL DEVICES AND DRUGS MARKET, CHAPTER 11 COMPANY PROFILES 108 ACUTRONIC MEDICAL SYSTEMS AG 108 TABLE 69 ACUTRONIC PRODUCTS 108 AIR LIQUIDE MEDICAL SYSTEMS S.A. 110 TABLE 70 AIR LIQUIDE PRODUCTS 110 TABLE 71 RECENT DEVELOPMENTS, ASTRAZENECA 111 TABLE 72 ASTRAZENECA PRODUCT 112

9 TABLE 73 RECENT DEVELOPMENTS, B. BRAUN 112 TABLE 74 B. BRAUN PRODUCTS 113 TABLE 75 RECENT DEVELOPMENTS, BAXTER INTERNATIONAL INC. 113 TABLE 76 BAXTER PRODUCTS 114 TABLE 77 RECENT DEVELOPMENTS, BECTON, DICKINSON AND COMPANY 114 TABLE 78 BECTON DICKINSON PRODUCTS 115 CAREFUSION CORP 115 TABLE 79 CAREFUSION PRODUCTS 116 TABLE 80 RECENT DEVELOPMENTS, CLARIS LIFESCIENCES 117 TABLE 81 CLARIS PRODUCTS 117 TABLE 82 RECENT DEVELOPMENTS, COVIDIEN PLC 119 TABLE 83 COVIDIEN PRODUCTS 119 TABLE 84 RECENT DEVELOPMENTS, DRAEGERWERK AG 122 TABLE 85 DRAEGERWERK PRODUCTS 123 TABLE 86 RECENT DEVELOPMENTS, FISHER & PAYKEL HEALTHCARE LIMITED 124 TABLE 87 FISHER & PAYKEL PRODUCTS 124 TABLE 88 RECENT DEVELOPMENTS ( ) 125 GE HEALTHCARE 125 TABLE 89 GE HEALTHCARE PRODUCTS 125 TABLE 90 RECENT DEVELOPMENTS, HALOCARBON PRODUCTS CORP. 128 TABLE 91 HALOCARBON PRODUCTS 128 TABLE 92 RECENT DEVELOPMENTS, HOSPIRA INC. 129 TABLE 93 HOSPIRA PRODUCTS 129 TABLE 94 RECENT DEVELOPMENTS ( ) 131 INTERSURGICAL LTD. 131 TABLE 95 INTERSURGICAL PRODUCTS 132 TABLE 96 RECENT DEVELOPMENTS, KING SYSTEMS CORPORATION 132 TABLE 97 KING SYSTEMS PRODUCTS 133 TABLE 98 RECENT DEVELOPMENTS, LMA INTERNATIONAL N.V. 134 TABLE 99 LMA INTERNATIONAL PRODUCTS 134 TABLE 100 RECENT DEVELOPMENTS, MASIMO CORP 137 TABLE 101 MASIMO PRODUCTS 137 TABLE 102 RECENT DEVELOPMENTS, PALL CORPORATION 138 TABLE 103 PALL PRODUCTS 138

10 TABLE 104 RECENT DEVELOPMENTS, PENLON 139 TABLE 105 PENLON PRODUCTS 140 TABLE 106 RECENT DEVELOPMENTS, PHILLIPS RESPIRONICS 142 TABLE 107 PHILLIPS PRODUCTS 142 TABLE 108 RECENT DEVELOPMENTS, PIRAMAL HEALTHCARE 143 TABLE 109 PIRAMAL PRODUCTS 144 RESMED CORP. 144 TABLE 110 RESMED PRODUCTS 145 TABLE 111 RECENT DEVELOPMENTS, SKYEPHARMA INC. 146 TABLE 112 SKYEPHARMA PRODUCTS 146 SMITHS MEDICAL 146 TABLE 113 SMITHS PRODUCTS 147 TABLE 114 RECENT DEVELOPMENTS, TELEFLEX INC. 148 TABLE 115 TELEFLEX PRODUCTS 149 TABLE 116 RECENT DEVELOPMENTS, TEVA PHARMACEUTICAL INDUSTRIES LTD. 150 TABLE 117 TAVA PRODUCTS 151 TABLE 118 RECENT DEVELOPMENTS, CHAPTER 12 PATENT ANALYSIS 153 FIGURE 4 PATENTS BY REGION, 2010 (NUMBER) 153 LIST OF PATENTS 154 UNITED STATES 154 TABLE 119 U.S. PATENTS 154 EUROPE PATENTS 157 TABLE 120 EUROPE PATENTS 157 JAPAN PATENTS 159 TABLE 121 JAPAN PATENTS 159

11 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES, THROUGH 2018 ($ TABLE 1 GLOBAL ANESTHESIA DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 2 GLOBAL ANESTHESIA DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 3 GLOBAL ANESTHESIA MACHINE MARKET BY TYPE, THROUGH 2018 ($ TABLE 4 GLOBAL ANESTHESIA MACHINE MARKET BY REGION, THROUGH 2018 ($ TABLE 5 GLOBAL ANESTHESIA WORKSTATION MARKET BY REGION, THROUGH 2018 ($ TABLE 6 GLOBAL ANESTHESIA DELIVERY MACHINE MARKET BY REGION, THROUGH 2018 ($ TABLE 7 GLOBAL ANESTHESIA VENTILATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 8 GLOBAL ANESTHESIA MONITOR MARKET BY REGION, THROUGH 2018 ($ TABLE 9 GLOBAL ANESTHESIA DISPOSABLES MARKET BY TYPE, THROUGH 2018 ($ TABLE 10 GLOBAL ANESTHESIA MASK MARKET BY REGION, THROUGH 2018 ($ TABLE 11 GLOBAL ANESTHESIA ACCESSORIES MARKET BY REGION, THROUGH 2018 ($ TABLE 12 GLOBAL RESPIRATORY DEVICE MARKET, THROUGH 2018 ($ 48 TABLE 13 GLOBAL RESPIRATORY DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 14 GLOBAL RESPIRATORY PRODUCT MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 15 GLOBAL RESPIRATORY PRODUCT MARKET BY REGION, THROUGH 2018 ($ TABLE 16 GLOBAL RESPIRATORY HUMIDIFIER MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 17 GLOBAL RESPIRATORY HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ TABLE 18 GLOBAL HEATED HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ TABLE 19 GLOBAL HEATED WIRE BREATHING CIRCUIT MARKET BY REGION, THROUGH 2018 ($ TABLE 20 GLOBAL HEATED EXCHANGER MARKET BY REGION, THROUGH 2018 ($ TABLE 21 GLOBAL PASSOVER HUMIDIFIER MARKET BY REGION, THROUGH 2018 ($ TABLE 22 GLOBAL NEBULIZER MARKET BY PRODUCT, THROUGH 2018 ($ 53 TABLE 23 GLOBAL NEBULIZER MARKET BY REGION, THROUGH 2018 ($ 54 TABLE 24 GLOBAL PNEUMATIC NEBULIZER MARKET BY REGION, THROUGH 2018 ($ TABLE 25 GLOBAL INTERMITTENT POSITIVE PRESSURE BREATHING NEBULIZER MARKET BY REGION, THROUGH 2018 ($ TABLE 26 GLOBAL ULTRASONIC NEBULIZER MARKET BY REGION, THROUGH 2018 ($

12 TABLE HEADING TABLE 27 GLOBAL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 28 GLOBAL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 29 GLOBAL CONTINUOUS POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 30 GLOBAL BI-LEVEL POSITIVE AIRWAY PRESSURE DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 31 GLOBAL OXYGEN CONCENTRATOR MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 32 GLOBAL OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 33 GLOBAL FIXED OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 34 GLOBAL PORTABLE OXYGEN CONCENTRATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 35 GLOBAL REUSABLE RESUSCITATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 36 GLOBAL VENTILATOR MARKET BY PRODUCT, THROUGH 2018 ($ 61 TABLE 37 GLOBAL VENTILATOR MARKET BY REGION, THROUGH 2018 ($ 61 TABLE 38 GLOBAL ADULT VENTILATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 39 GLOBAL NEONATAL VENTILATOR MARKET BY REGION, THROUGH 2018 ($ TABLE 40 GLOBAL RESPIRATORY INHALER MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 41 GLOBAL RESPIRATORY INHALER MARKET BY REGION, THROUGH 2018 ($ TABLE 42 GLOBAL DRY POWDERED INHALER MARKET BY REGION, THROUGH 2018 ($ TABLE 43 GLOBAL METERED DOSE INHALER MARKET BY REGION, THROUGH 2018 ($ TABLE 44 GLOBAL RESPIRATORY DISPOSABLES MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 45 GLOBAL RESPIRATORY DISPOSABLES MARKET BY REGION, THROUGH 2018 ($ TABLE 46 GLOBAL DISPOSABLES - OXYGEN MASK MARKET BY REGION, THROUGH 2018 ($ TABLE 47 GLOBAL RESUSCITATOR MARKET BY REGION, THROUGH 2018 ($ 67 TABLE 48 GLOBAL TRACHEOSTOMY TUBE MARKET BY REGION, THROUGH 2018 ($ TABLE 49 GLOBAL OXYGEN CANNULA MARKET BY REGION, THROUGH 2018 ($ TABLE 50 GLOBAL RESPIRATORY MEASUREMENT DEVICE MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 51 GLOBAL RESPIRATORY MEASUREMENT DEVICE MARKET BY REGION, THROUGH 2018 ($ TABLE 52 GLOBAL PULSE OXIMETER SYSTEM MARKET BY PRODUCT, THROUGH 2018 ($ TABLE 53 GLOBAL PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($

13 TABLE HEADING TABLE 54 GLOBAL HANDHELD PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($ TABLE 55 GLOBAL TABLE TOP PULSE OXIMETER SYSTEM MARKET BY REGION, THROUGH 2018 ($ TABLE 56 GLOBAL PULSE OXIMETER SENSOR MARKET BY REGION, THROUGH 2018 ($ TABLE 57 GLOBAL CAPNOGRAPH MARKET BY REGION, THROUGH 2018 ($ 72 TABLE 58 GLOBAL SPIROMETER MARKET BY PRODUCT, THROUGH 2018 ($ 72 TABLE 59 GLOBAL SPIROMETER MARKET BY REGION, THROUGH 2018 ($ 73 TABLE 60 GLOBAL MECHANICAL VOLUME SPIROMETER MARKET BY REGION, THROUGH 2018 ($ TABLE 61 GLOBAL AUTOMATED FLOW SPIROMETER MARKET BY REGION, THROUGH 2018 ($ TABLE 62 GLOBAL PEAK FLOW METER MARKET BY REGION, THROUGH 2018 ($ TABLE 63 GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES BY REGION, THROUGH 2018 ($ TABLE 64 PRODUCT LAUNCHES AND APPROVALS IN MEDICAL DEVICES AND DRUGS MARKET, 2012 AND 2013 TABLE 65 MERGERS AND ACQUISITIONS IN THE MEDICAL DEVICES AND DRUGS MARKET, TABLE 66 AGREEMENT, JOINT VENTURE, DIVESTMENT AND INVESTMENT IN MEDICAL DEVICES AND DRUGS MARKET, TABLE 67 EXPANSION, REORGANIZATION AND R&D FACILITIES IN MEDICAL DEVICES & DRUGS MARKET, ($ TABLE 68 CERTIFICATION AND SERVICE IN MEDICAL DEVICES AND DRUGS MARKET, TABLE 69 ACUTRONIC PRODUCTS 108 TABLE 70 AIR LIQUIDE PRODUCTS 110 TABLE 71 RECENT DEVELOPMENTS, TABLE 72 ASTRAZENECA PRODUCT 112 TABLE 73 RECENT DEVELOPMENTS, TABLE 74 B. BRAUN PRODUCTS 113 TABLE 75 RECENT DEVELOPMENTS, TABLE 76 BAXTER PRODUCTS 114 TABLE 77 RECENT DEVELOPMENTS, TABLE 78 BECTON DICKINSON PRODUCTS 115 TABLE 79 CAREFUSION PRODUCTS 116 TABLE 80 RECENT DEVELOPMENTS, TABLE 81 CLARIS PRODUCTS 117 TABLE 82 RECENT DEVELOPMENTS, TABLE 83 COVIDIEN PRODUCTS 119 TABLE 84 RECENT DEVELOPMENTS, TABLE 85 DRAEGERWERK PRODUCTS 123 TABLE 86 RECENT DEVELOPMENTS, TABLE 87 FISHER & PAYKEL PRODUCTS 124 TABLE 88 RECENT DEVELOPMENTS ( ) 125 TABLE 89 GE HEALTHCARE PRODUCTS 125 TABLE 90 RECENT DEVELOPMENTS, TABLE 91 HALOCARBON PRODUCTS

14 TABLE HEADING TABLE 92 RECENT DEVELOPMENTS, TABLE 93 HOSPIRA PRODUCTS 129 TABLE 94 RECENT DEVELOPMENTS ( ) 131 TABLE 95 INTERSURGICAL PRODUCTS 132 TABLE 96 RECENT DEVELOPMENTS, TABLE 97 KING SYSTEMS PRODUCTS 133 TABLE 98 RECENT DEVELOPMENTS, TABLE 99 LMA INTERNATIONAL PRODUCTS 134 TABLE 100 RECENT DEVELOPMENTS, TABLE 101 MASIMO PRODUCTS 137 TABLE 102 RECENT DEVELOPMENTS, TABLE 103 PALL PRODUCTS 138 TABLE 104 RECENT DEVELOPMENTS, TABLE 105 PENLON PRODUCTS 140 TABLE 106 RECENT DEVELOPMENTS, TABLE 107 PHILLIPS PRODUCTS 142 TABLE 108 RECENT DEVELOPMENTS, TABLE 109 PIRAMAL PRODUCTS 144 TABLE 110 RESMED PRODUCTS 145 TABLE 111 RECENT DEVELOPMENTS, TABLE 112 SKYEPHARMA PRODUCTS 146 TABLE 113 SMITHS PRODUCTS 147 TABLE 114 RECENT DEVELOPMENTS, TABLE 115 TELEFLEX PRODUCTS 149 TABLE 116 RECENT DEVELOPMENTS, TABLE 117 TAVA PRODUCTS 151 TABLE 118 RECENT DEVELOPMENTS, TABLE 119 U.S. PATENTS 154 TABLE 120 EUROPE PATENTS 157 TABLE 121 JAPAN PATENTS 159

15 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL MARKET FOR ANESTHETIC AND RESPIRATORY DEVICES, ($ FIGURE 1 SEGMENTATION OF THE ANESTHESIA DEVICES AND DRUGS MARKET 10 FIGURE 2 TECHNOLOGICAL INNOVATIONS IN ANESTHESIA AND RESPIRATORY DEVICES FIGURE 3 STRATEGIES FOLLOWED IN THE ANESTHETIC DEVICES AND DRUGS MARKET BY MARKET PLAYERS 2011 TO SEPTEMBER 2013 (NO.) FIGURE 4 PATENTS BY REGION, 2010 (NUMBER)