DAVID C. KOSEGARTEN, PH.D., R.PH.

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1 MASTERING PHARMACY UCEIMSURE & CERTIFICATION A CASE-RASED REVIEW DAVID C. KOSEGARTEN, PH.D., R.PH. Associate Professor of Pharmacology and Toxicology Massachusetts College of Pharmacy and Health Sciences Boston, Massachusetts DOUGLAS J. PISANO, PH.D., R.PH. Associate Professor of Pharmacy Administration Massachusetts College of Pharmacy and Health Sciences Boston, Massachusetts F. RANDY VOGENBERG, PH.D., R.PH. Director and National Practice Leader ASA Health System Education and Pharmaceutical Consulting Wellesley, Massachusetts Deans' Professor of Pharmacy Management Philadelphia College of Pharmacy Philadelphia, Pennsylvania MCGRAW-HILL, INC. MEDICAL PUBLISHING DIVISION New York San Francisco Washington, D.C. Auckland Bogota Caracas Lisbon London Madrid Mexico City Milan Montreal New Delhi San Juan Singapore Sydney Tokyo Toronto

2 Contents II Part I Case Presentations and Questions Coronary Artery Disease Hypertension Seizure Disorders Buffer Solutions Bacteremia and Sepsis Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) Oncology/Breast Cancer Medicinal Chemistry Case #1 Panic Disorder Renal Transplantation Controlled Substances Act (C.S.A.) Arrhythmias Hypertension Seizure Disorders Antibiotic Suspensions Bacteremia and Sepsis Opportunistic Infections Oncology/Prostate Cancer Medicinal Chemistry Case # II

3 <L Contents 20 Generalized Anxiety Disorder Renal Transplantation Controlled Substances Act (C.S.A.) Arrhythmias Diabetes Mellitus 52 Nicole Turcotte 25 Seizure Disorders Constitution and Flow Rates Bacteremia and Sepsis Sexually Transmitted Diseases Oncology/Colon Cancer Medicinal Chemistry Case # Major Depression Renal Transplantation Controlled Substances Act (C.S.A.) Coronary Artery Disease Diabetes Mellitus Seizure Disorders Radiopharmaceuticals Bacteremia and Sepsis Sexually Transmitted Diseases and Human Immunodeficiency Syndrome (HIV) 82

4 Contents XI Oncology/Lung Cancer Medicinal Chemistry Case #4 Major Depression Urinary Tract Infections Food, Drug, and Cosmetic Act (F.D.C.A.) Coronary Artery Disease Diabetes Mellitus Asthma Antacid Suspensions Respiratory Tract Infections Tuberculosis Oncology/Ovarian Cancer Medicinal Chemistry Case #5 Bipolar Disorder Urinary Tract Infections Food, Drug, and Cosmetic Act (F.D.C.A.) Coronary Artery Disease Asthma Ointments Respiratory Tract Infections Tuberculosis III

5 XII Contents 61 Oncology/Lymphoma (Hodgkin's) Medicinal Chemistry Case # Bipolar Disorder Urinary Tract Infections Prescription Drug Marketing Act (P.D.M.A.) Coronary Artery Disease Hypercholesterolemia Asthma Elixirs Respiratory Tract Infections Dermatology Oncology/ALL (Pediatric) Medicinal Chemistry Case # Schizophrenia Parkinsons Disease Mid-Level Practitioners Congestive Heart Failure Hypercholesterolemia Asthma Compounding Capsules Soft Tissue Infections 166

6 Contents XIM 82 Dermatology/Acne Oncology/CML (Adult) Medicinal Chemistry Case # Schizophrenia Parkinsons Disease Poison Prevention Packaging Act (P.P.P.A.) Congestive Heart Failure Thyroid Disease Chronic Obstructive Lung Disease Parenteral Nutrition Soft Tissue Infections Osteoporosis Oncology/Nausea and Vomiting Control Medicinal Chemistry Case # Opiate Abuse Parkinsons Disease Expiration Dating and NDC Code Arrhythmias Thyroid Disease Chronic Obstructive Lung Disease Eye Drops 206

7 XIV Contents 103 Soft Tissue Infections 104 Osteoporosis 105 Oncology/Pain Control 106 Medicinal Chemistry Case # Alcohol Abuse 108 Over-the-Counter Drugs 109 Congestive Heart Failure/Arrhythmias 110 Thyroid Disease 111 Chronic Obstructive Lung Disease 112 Arrhythmias 113 Hypertension 114 Hypertension Down Chandler-Toufieli 115 Hypertension 116 Anticoagulation 117 Anticoagulation 118 Anticoagulation 119 Hypercholesterolemia 120 Hypercholesterolemia Part II Answers with Explanations and Answers Appendix Subject Index References

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