Title: Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

Size: px
Start display at page:

Download "Title: Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies"

Transcription

1 Author s response to reviews Title: Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies Authors: Matthew Machin (matthew.machin12@imperial.ac.uk) Andre Amaral (a.amaral@imperial.ac.uk) Matthias Wielscher (m.wielscher@imperial.ac.uk) Faisal Rezwan (F.Rezwan@soton.ac.uk) Medea Imboden (medea.imboden@unibas.ch) Marjo-Riitta Jarvelin (m.jarvelin@imperial.ac.uk) Ian Adcock (ian.adcock@imperial.ac.uk) Nicole Probst-Hensch (Nicole.Probst@unibas.ch) John Holloway (J.W.Holloway@soton.ac.uk) Deborah Jarvis (d.jarvis@imperial.ac.uk) Version: 1 Date: 30 Jan 2017 Author s response to reviews: We would like to thank the editor for this opportunity to present our revised manuscript. Reviewer #1 Machin and colleagues present a systematic review of lung function and COPD. The manuscript is well written and the methods in accordance with PRISMA. In general the work is a good contribution to summarize the growing literature in the field of epigenetics and respiratory health and disease. There are minor issues that need addressing that will improve the manuscript. C1. Update to literature.

2 I note one additional study in an African American cohort of subjects published after the last date of indexing. Busch PUBMED ID This could be considered for inclusion if not burdensome but the cutoff of literature searching is well referenced in the manuscript. R1. The paper by Busch et al. has only been made public on 5 November 2016, during the review process of our manuscript. However, we have mentioned this paper in the discussion. C2. Correction to comments about Qiu et al study. The authors suggest that different criteria were used to define COPD in the Qiu study. This is not the case. The enrollment to the parent study is as stated on page 17 but both ICGN and EOCOPD used cutoff on a ratio of 0.7 to define COPD (published manuscript main text methods). Therefore line 55 on page 17 should be corrected with regard to the suggestion that "there was little consistency in the definition of COPD even within the same report". Also relevant in line 33 page 9. R2. We have corrected it. C3. Minor-please be sure that the first authors last name is spelled correctly as Qiu. (Table 9 legend - Qui, line 24 page 16 Qui) R3. We have corrected it. C4. Minor-the reference for this paper #24 does not include a complete author list or et al). R4. We have corrected it. C5. Page 14 line 29-the focus of the published results was the overlap CpG for COPD and lung function. All of those data are in the supplement of the manuscript. R5. We have deleted this sentence. C6. Grey literature

3 It would be helpful to the reader to have a definition of "grey" literature. R6. We have added it to the text as grey literature (i.e. published in non-commercial form or that falls outside the mainstream of journal and monograph publications). C7. Word choice regarding topic of study. Since the focus of the review is cross sectional methylation the authors might swap out "Epigenetic chnage" with "epigenetic variation" to better convey that change is not being measured in the highlighted studies. R7. We have changed it to epigenetic variation. Reviewer #2 Machen and colleagues reviewed the current literature to identify biomarkers of COPD identified by epigenetic changes linked to lung function. From population-based studies, the authors examined previously published datasets of DNA methylation profiles in peripheral blood from COPD subjects. Of the 1155 articles identified, only 6 papers were further reviewed. Authors found no significant CpG sites were consistently observed following combining these studies. This manuscript addresses a clinically important disease that requires new biomarkers to determine key biological plays in disease. However, in its present state the manuscript is not a research article but a review of the current COPD blood DNA methylation literature. As a review article, the manuscript is descriptive and requires major editing to become a review article. There are several items that require addressing. These are itemized below, not in order of significance, but in order of presentation. Major: C8. The major problem with this article is that its presented as research but it's a review article. As a review article, the layout of the paper would require major editing. Therefore, a methods section would not be needed. This could be removed and condensed into each subsection of the paper. R8. Our manuscript has been prepared following the guidelines for a systematic review, which includes a methods section so that others can replicate our findings. BMC Pulmonary Medicine does not have a specific section for Systematic Reviews, but these have been frequently published under the section of Research Articles (e.g. Hawkins et al doi: /s ; McLean et al doi: /s ; Wang et al doi: /s y). However, we have shortened the methods and moved a table to the supplement.

4 C9. Since epigenetics is a relatively modern technic, why were conference abstracts excluded? R9. As many conference abstracts do not reflect the final conclusion, often require changes/corrections prior to publication, and the amount of information provided on the methods is limited, these are not commonly included in systematic reviews. C10. Many lung tissue epigenetic papers exist that may aid in the discussing of this review. Please discuss the finding from these 6 papers compared to lung tissue epigenetic data. Are any CpG sites relevant compared to the lung data? R10. We aimed to explore the relationship of DNA methylation with lung function and COPD using samples that could realistically be obtained in a usual clinical setting (i.e. peripheral blood). It is beyond the scope of our article to systematically review the lung tissue reports, but we believe that, to date, there are no consistent unambiguous evidence of association with any particular sites in such tissue samples. In addition, we feel that studies using lung tissue may not be comparable to those using peripheral blood. C11. Were there any differences in the adjustment for confounders from study to study? Or were any consistent biomarkers reported between these studies prior to adjusting data to confounders? R11. The adjustment for confounders varied considerably across studies. However, most adjusted for age and smoking, and a few for sex too. We have commented on this issue in the discussion. C12. Authors state that there was a lack of consistency in the definition of COPD. What are the ethnicity breakdown in each of these studies? Please discuss this in greater detail in this lack of consistency section. R12. While some studies reported the proportions of different races/ethnicities in their sample, others did not. Lepeule et al. and Lange et al. reported the proportions of white and non-white participants, and adjusted their analyses for race/ethnicity. Participants in the studies by Qiu et al. and Marioni et al. were all white. Bell et al. and Wieslscher et al. did not provide a race/ethnicity breakdown. We have added this information to the lack of consistency section.

5 C13. Smoking history is unavailable for several of the studies. The studies that do supply a smoking history vary hugely. Please discuss this important factor in greater detail. R13. We have discussed it in further detail. C14. Since the studies primarily focus on leukocytes, was any exacerbation data available for each study cohort? This would greatly alter these profiles. Please discuss in greater detail. R14. None of the studies provided information on whether the samples had been collected during an exacerbation episode or not. We have added this information to the discussion. C15. Expansion of identified CpG sites and genes would be helpful. Why are these sites only listed from 2 papers (Qiu and Wielscher et al)? The 4 other papers must have similar data associated with lung function R15. We have deleted tables 7 through to 9. Minor: C16. On page 5 line 58, remove "(authors DJ and MM)." And again, on page 8 line 2. R16. On page 5, we have changed this sentence to Titles and Abstracts of articles were screened by two authors (DJ and MM) against the predefined inclusion criteria (Table 2) to identify articles for full-text review. On page 8, we have deleted it. Reviewer #3 The authors performed a systematic literature review of studies on DNA methylation with lung outcomes. They did a good job in terms of the systematic review, which I believe was comprehensive. The overall conclusion is that there is too much heterogeneity across study designs and methods; combining the results is not possible. I think this is an important conclusion, not only for the pulmonary DNA methylation studies, but all methylation work in the future. Comments: Abstract:

6 C17. Please name the lung function test (FEV1, FEV1/FVC ratio) earlier in the abstract (methods). R17. We have done it. C18. First sentence of Conclusions is again introduction, please omit. R18. We have deleted this sentence. Introduction: C19. I wouldn t say CpG base-pairs are "rare" R19. We have deleted the word rare and changed the sentence to These CpG base-pairs are concentrated in relatively high densities in areas known as CpG islands (CGIs). Results: C20. When I do = =21, instead of 16. Please correct this (from the figure, I get 1139). R20. We have corrected the text. It now reads as This step excluded 1,139 articles, leaving 16 articles for full-text review. C21, Study approaches: page 8 line is equal to line Please omit the last sentence (Lepeule et al. [26] adopted a candidate-loci approach whereas Lange et al. [27] performed global methylation analysis.) R21. We have deleted it. C22. Cell type corrections: please state whether the cell counts were imputed using Houseman method, or directly measured. R22. We have clarified this in the text ( All other articles adjusting for differing white cells used relative proportions of the cell types, which were directly measured ).

7 C23. Page 17, line 12: the ")" is placed incorrectly. R23. We have corrected it. Discussion: C24. In the second paragraph the authors start with the lack of consistency across studies, which I agree is very important. However, the first example is the COPD definition, which I believe is not the most important inconsistency. I think cell count adjustment and replication of results is crucial. To stress this out, please omit the COPD definition difference from the start of the paragraph. R24. We have deleted it. C25. I believe that the discussion can be more focused on the pitfalls of the published methylation studies. Already in the first paragraph I would stress out the lacks of the prior studies (cell count correction, confounder adjustment, smoking problems, lack of replication (which we know from gwas is crucial!). Furthermore, I think that the discussion can be shortened, for instance the paragraphs on the specific genes are a bit too much, I assume this is also discussed in the individual papers. And the findings are based on suboptimal study designs. R25. We have discussed these points further, and have followed the suggestion of shortening the discussion by deleting the paragraphs on specific genes. Reviewer #4 In "Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies", Machin and colleagues perform a systematic review of the published literature on blood DNA methylation in relation with COPD and lung function, to evaluate if there are any evidence of common CpGs associated with these traits cross-publications. From their analyses they conclude that in the current body of work no consistent findings have been reported for these traits. However, they note that two of the studies report associations at genes in the same pathway. The aim of the study was well defined, however, there remain some issues to be addressed. The heterogeneous nature of the analyses and phenotypes in the included papers are obviously one of the concerns in drawing conclusions from the systemic review of the results.

8 C26. Did the authors try to get access to the full list of significantly associated CpGs for the ICGN cohort in the Qiu et al. paper? I think that it would be useful if you could provide the analysis across all significant CpGs, to be able to draw proper conclusions. R26. We have checked the 349 CpGs listed in the Qiu et al s online supplement and could not find any of the significant hits from the other studies on that list. C27. The authors state (page 12, 18 and Table 5) that batch correction in the three EWAS studies was performed using principle component analysis (should be principal component analysis). While Bell et al. used PCA in identification of technical factors that may be potential confounders, neither Marioni et al. nor Bell et al. used principal components to correct for known confounding factors but rather included these factors directly as covariates in the models. In the third paper by Qiu et al., the authors report that they include indicator variables for batch effects in the linear models. It is unclear what this mean, but they do not mention using PCA. Please clarify. R27. We have reworded these sentences and have deleted the column Batch correction from table 5 (now table 4). C28. In some of the included papers, CpG probes were excluded based on some criteria (not listed), which the authors refer to as a sensitivity analysis (page 12, line 26-27). Can you please explain further what the authors of the original work did, and how this constitutes as a sensitivity analysis? R28. This refers to quality control, rather than statistical sensitivity analysis we have reworded this part of the text. C29. In the candidate studies, are more than one CpG included per loci/genomic region? If you would do the analysis on genomic region/gene basis rather than exact CpG do you observe any overlap between candidate and EWAS studies? R29. We have checked whether the significant genes in the candidate studies overlapped with those of the EWAS, and they did not.

9 C30. Were the CpGs tested in the candidate studies all included on either the 27k (or 450k) array used in the EWAS studies? R30. The CpGs tested by Wielscher et al. are present in the 450k array. However, Lepeule et al. and Lange et al. did not examine CpG sites as in the arrays they examined positions in the promoter region of genes (Lepeule et al.) and repetitive elements (i.e. Alu and LINE1; Lange et al.), which are not comparable to the CpG sites tested in by Qiu et al., Marioni et al. and Bell et al. C31. The authors state that Bell et al. account for probes with a SNP (page 18, line 26). Please explain. R31. We have deleted this sentence. C32. Is blood the correct tissue for addressing questions of causality for these traits? Besides studies looking at longitudinal changes would it not also be useful with larger studies, using denser arrays/sequencing, of lung function and COPD? R32. The use of lung tissue may be more informative than peripheral blood in terms of assessing causality between a risk factor and COPD. However, our interest is in identifying markers of abnormal lung function and COPD in samples that can be collected easily in a clinical/primary care setting these may inform future studies evaluating temporal changes in these markers in relation to lung function decline and disease progression and even before clinical signs are evident. C33. Please add a list of the abbreviations to the manuscript (as per requirements). R33. We have added a list of abbreviations and acronyms. C34. What is Table 7 showing? Please clarify in the legend or footnote whether the p-values are from analysis in the ICGN or EOCOPD cohort, meta-analysis of both? R34. We have deleted this table. C35. The authors write that pack years "..varied widely between individuals and possibly between studies". Did pack year vary between studies or not?

10 R35. Smoking history varied across studies. We have corrected this sentence. C36. How many significant associations did Qiu et al report in models adjusted for confounding factors? R36. This information is not clear in Qiu et al. s paper. In their supplement, only the top 100 CpGs for model II (adjusted for confounders) in ICGN were listed. They also presented a list of 349 hits for both ICGN and EOCOPD for COPD and lung function, but these are from the unadjusted analyses. C37. Are the two CpG sites in the SERPINA1 gene (reported in Qiu et al.) in the same CGI or different CGIs? R37. Neither cg nor cg are part of a CGI. C38. As a different p-value threshold was used in the replication in Qui et al. (page 14, line 39-41) state both p-values in the text. R38. We have added these to the text. C39. When discussing Leupele et al study, please also state if any of these are associated in the other studies (page 17, line 23)? R39. Lepeule et al. examined the levels of methylation in several positions in the promoter region of a specific group of genes. Their sites were not coded as CpG sites and could not be compared to those of the other studies. We have modified the text to make this clear. Some minor comments/spelling mistakes C40. Include et al either as italic or as normal font (not both). R40. We have corrected it. C41. Page 3, line 55: Use defined abbreviation for CpG islands

11 R41. We have corrected it. C42. Page 14, line 22: Missing word. "Qiu et al. reported COPD was associated with" R42. We have corrected it. C43. Page 14, line 55: Missing full stop after "from the Qiu et al report" R43. We have corrected it. C44. Page 17, lines 1-14: parenthesis in the wrong place. If possible split the sentence to improve readability. R44. We have corrected it and made the sentence easier to read. C45. Page 17, line 19: two --> too R45. We have corrected it. C46. Additional File: Remove the duplicate entry for the paper by Barret et al. R46. We have corrected it.

Author's response to reviews

Author's response to reviews Author's response to reviews Title:Does the 2013 GOLD classification improve the ability to predict lung function decline, exacerbations and mortality? A post-hoc analysis of the 4-year UPLIFT trial Authors:

More information

Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka

Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka Author s response to reviews Title: Use of food labels by adolescents to make healthier choices on snacks: a cross sectional study from Sri Lanka Authors: Ishanka Talagala (drmaheshkeerthi@gmail.com;drishanka@gmail.com)

More information

2) Cases and controls were genotyped on different platforms. The comparability of the platforms should be discussed.

2) Cases and controls were genotyped on different platforms. The comparability of the platforms should be discussed. Reviewers' Comments: Reviewer #1 (Remarks to the Author) The manuscript titled 'Association of variations in HLA-class II and other loci with susceptibility to lung adenocarcinoma with EGFR mutation' evaluated

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Pneumococcal vaccination and otitis media in Australian Aboriginal infants: comparison of two birth cohorts before and after introduction of vaccination Authors: Grant

More information

Title: Reporting and Methodologic Quality of Cochrane Neonatal Review Group Systematic Reviews

Title: Reporting and Methodologic Quality of Cochrane Neonatal Review Group Systematic Reviews Author's response to reviews Title: Reporting and Methodologic Quality of Cochrane Neonatal Review Group Systematic Reviews Authors: Khalid M. AlFaleh (kmfaleh@hotmail.com) Mohammed AlOmran (m_alomran@hotmail.com)

More information

Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer

Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer Author's response to reviews Title: The effect of Breast Cancer Awareness Month on Internet search activity - a comparison with awareness campaigns for lung and prostate cancer Authors: Ronan W Glynn (ronanglynn@doctors.net.uk)

More information

Please revise your paper to respond to all of the comments by the reviewers. Their reports are available at the end of this letter, below.

Please revise your paper to respond to all of the comments by the reviewers. Their reports are available at the end of this letter, below. Dear editor and dear reviewers Thank you very much for the additional comments and suggestions. We have modified the manuscript according to the comments below. We have also updated the literature search

More information

Epigenetics. Jenny van Dongen Vrije Universiteit (VU) Amsterdam Boulder, Friday march 10, 2017

Epigenetics. Jenny van Dongen Vrije Universiteit (VU) Amsterdam Boulder, Friday march 10, 2017 Epigenetics Jenny van Dongen Vrije Universiteit (VU) Amsterdam j.van.dongen@vu.nl Boulder, Friday march 10, 2017 Epigenetics Epigenetics= The study of molecular mechanisms that influence the activity of

More information

Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival.

Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival. Author's response to reviews Title: Survival endpoints in colorectal cancer. The effect of second primary other cancer on disease free survival. Authors: Helgi Birgisson (helgi.birgisson@surgsci.uu.se)

More information

Author s response to reviews

Author s response to reviews Author s response to reviews Title: The validity of a professional competence tool for physiotherapy students in simulationbased clinical education: a Rasch analysis Authors: Belinda Judd (belinda.judd@sydney.edu.au)

More information

UNIVERSITY OF CALIFORNIA, LOS ANGELES

UNIVERSITY OF CALIFORNIA, LOS ANGELES UNIVERSITY OF CALIFORNIA, LOS ANGELES BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO UCLA SANTA BARBARA SANTA CRUZ DEPARTMENT OF EPIDEMIOLOGY SCHOOL OF PUBLIC HEALTH CAMPUS

More information

MJ - Decision on Manuscript ID BMJ

MJ - Decision on Manuscript ID BMJ MJ - Decision on Manuscript ID BMJ.2018.044966 Body: 12-Jul-2018 Dear Dr. Khandwala Manuscript ID BMJ.2018.044966 entitled "The Association of Paternal Age and Perinatal Outcomes between 2007 and 2016

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Specific Gene Expression Profiles and Unique Chromosomal Abnormalities are Associated with Regressing Tumors Among Infants with Dissiminated Neuroblastoma. Authors:

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Diabetes duration and health-related quality of life in individuals with onset of diabetes in the age group 15-34 years - a Swedish population-based study using EQ-5D

More information

Title: Home Exposure to Arabian Incense (Bakhour) and Asthma Symptoms in Children: A Community Survey in Two Regions in Oman

Title: Home Exposure to Arabian Incense (Bakhour) and Asthma Symptoms in Children: A Community Survey in Two Regions in Oman Author's response to reviews Title: Home Exposure to Arabian Incense (Bakhour) and Asthma Symptoms in Children: A Community Survey in Two Regions in Oman Authors: Omar A Al-Rawas (orawas@squ.edu.om) Abdullah

More information

Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach

Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach Author's response to reviews Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in Gastric Cancer: A Comprehensive Profiling Approach Authors: Marie Loh (m.loh@imperial.ac.uk) Natalia

More information

MEMO TO: Author FROM: Lauren Montemurri DATE: March 28, 2011 RE: CAM utilization study edits

MEMO TO: Author FROM: Lauren Montemurri DATE: March 28, 2011 RE: CAM utilization study edits MEMO TO: Author FROM: Lauren Montemurri DATE: March 28, 2011 RE: CAM utilization study edits The purpose of this memo is to discuss the developmental edits needed for the CAM utilization study article.

More information

Publishing Your Study: Tips for Young Investigators. Learning Objectives 7/9/2013. Eric B. Bass, MD, MPH

Publishing Your Study: Tips for Young Investigators. Learning Objectives 7/9/2013. Eric B. Bass, MD, MPH Publishing Your Study: Tips for Young Investigators Eric B. Bass, MD, MPH Learning Objectives To apply a logical approach to organizing & presenting your work in a manuscript To recognize the importance

More information

Conflict of interest in randomised controlled surgical trials: Systematic review, qualitative and quantitative analysis

Conflict of interest in randomised controlled surgical trials: Systematic review, qualitative and quantitative analysis Reviewer Assessment Open Access P. Probst, K. Grummich, U. Klaiber, P. Knebel, A.Ulrich, M. W. Büchler, and M. K. Diener* Conflict of interest in randomised controlled surgical trials: Systematic review,

More information

Title: Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study

Title: Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study Author's response to reviews Title: Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study Authors: Marie F Sorbo (marie.flem.sorbo@ntnu.no) Hilde Grimstad (hilde.grimstad@ntnu.no)

More information

Reviewers' comments: Reviewer #1 (Remarks to the Author):

Reviewers' comments: Reviewer #1 (Remarks to the Author): Reviewers' comments: Reviewer #1 (Remarks to the Author): Major claims of the paper A well-designed and well-executed large-scale GWAS is presented for male patternbaldness, identifying 71 associated loci,

More information

Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter?

Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter? Author's response to reviews Title:Modern contraceptive use among sexually active men in Uganda: Does discussion with a health worker matter? Authors: Allen Kabagenyi Ms. (allenka79@yahoo.com) Patricia

More information

Jose Merino (Chair), Georg Roeggla, Tiago Villaneuva, John Fletcher. Amy Price, Elisabeth Loder. Jamie Kirhham (statisticians), Rubin Minhas

Jose Merino (Chair), Georg Roeggla, Tiago Villaneuva, John Fletcher. Amy Price, Elisabeth Loder. Jamie Kirhham (statisticians), Rubin Minhas BMJ.2017.037871 "Efficacy of drugs used in preventive chemotherapy against soil-transmitted helminths: systematic review and network meta-analysis" *********************************************************************************************************

More information

2. Could you insert a reference, proving your statement on p. 5, l. 66/67?

2. Could you insert a reference, proving your statement on p. 5, l. 66/67? Author s response to reviews Title: Representative survey on idiopathic environmental intolerance attributed to electromagnetic fields in Taiwan and comparison with the international literature Authors:

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title:Mental health problems in the 10th grade and non-completion of upper secondary school: the mediating role of grades in a population-based longitudinal study Authors:

More information

Title:Prediction of poor outcomes six months following total knee arthroplasty in patients awaiting surgery

Title:Prediction of poor outcomes six months following total knee arthroplasty in patients awaiting surgery Author's response to reviews Title:Prediction of poor outcomes six months following total knee arthroplasty in patients awaiting surgery Authors: Eugen Lungu (eugen.lungu@umontreal.ca) François Desmeules

More information

Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study

Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Author's response to reviews Title: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Authors: Atsuko Sekita (atsekita@med.kyushu-u.ac.jp)

More information

Title:The self-reported health of U.S. flight attendants compared to the general population

Title:The self-reported health of U.S. flight attendants compared to the general population Author's response to reviews Title:The self-reported health of U.S. flight attendants compared to the general population Authors: Eileen McNeely (emcneely@hsph.harvard.edu) Version:4Date:30 January 2014

More information

Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles Author's response to reviews Title: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles Authors: Julia Tchou (julia.tchou@uphs.upenn.edu) Andrew V Kossenkov (akossenkov@wistar.org)

More information

Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey

Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey Author's response to reviews Title:Continuity of GP care is associated with lower use of complementary and alternative medical providers A population-based cross-sectional survey Authors: Anne Helen Hansen

More information

Manuscript ID BMJ R1 entitled "Education and coronary heart disease: a Mendelian randomization study"

Manuscript ID BMJ R1 entitled Education and coronary heart disease: a Mendelian randomization study BMJ - Decision on Manuscript ID BMJ.2017.03 7504.R1 Body: 11-May-2017 Dear Dr. Tillmann Manuscript ID BMJ.2017.037504.R1 entitled "Education and coronary heart disease: a Mendelian randomization study"

More information

GENOME-WIDE ASSOCIATION STUDIES

GENOME-WIDE ASSOCIATION STUDIES GENOME-WIDE ASSOCIATION STUDIES SUCCESSES AND PITFALLS IBT 2012 Human Genetics & Molecular Medicine Zané Lombard IDENTIFYING DISEASE GENES??? Nature, 15 Feb 2001 Science, 16 Feb 2001 IDENTIFYING DISEASE

More information

BMJ - Decision on Manuscript ID BMJ

BMJ - Decision on Manuscript ID BMJ BMJ - Decision on Manuscript ID BMJ.2018.043414 Body: 19-Feb-2018 Dear Mr. Lee Manuscript ID BMJ.2018.043414 entitled "Predicted lean body mass, fat mass, and all-cause and cause-specific mortality in

More information

Blood Pressure and Complications in Individuals with Type 2 Diabetes and No Previous Cardiovascular Disease. ID BMJ

Blood Pressure and Complications in Individuals with Type 2 Diabetes and No Previous Cardiovascular Disease. ID BMJ 1 Blood Pressure and Complications in Individuals with Type 2 Diabetes and No Previous Cardiovascular Disease. ID BMJ 2016.033440 Dear Editor, Editorial Committee and Reviewers Thank you for your appreciation

More information

Title: The size of the population potentially in need of palliative care in Germany - An estimation based on death registration data

Title: The size of the population potentially in need of palliative care in Germany - An estimation based on death registration data Author s response to reviews Title: The size of the population potentially in need of palliative care in Germany - An estimation based on death registration data Authors: Nadine Scholten (nadine.scholten@uk-koeln.de)

More information

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL) PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL) PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Physiotherapy interventions in scientific physiotherapy publications focusing on interventions for children with cerebral palsy: A qualitative phenomenographic approach.

More information

Reviewer s report. Version: 0 Date: 17 Dec Reviewer: Julia Marcus. Reviewer's report:

Reviewer s report. Version: 0 Date: 17 Dec Reviewer: Julia Marcus. Reviewer's report: Reviewer s report Title: Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with human immunodeficiency virus (HIV)?: a cohort collaboration

More information

EFFECTIVE MEDICAL WRITING Michelle Biros, MS, MD Editor-in -Chief Academic Emergency Medicine

EFFECTIVE MEDICAL WRITING Michelle Biros, MS, MD Editor-in -Chief Academic Emergency Medicine EFFECTIVE MEDICAL WRITING Michelle Biros, MS, MD Editor-in -Chief Academic Emergency Medicine Why We Write To disseminate information To share ideas, discoveries, and perspectives to a broader audience

More information

Title:Environmental footprints of Mediterranean versus Western Dietary Patterns: Beyond the health benefits of the Mediterranean Diet

Title:Environmental footprints of Mediterranean versus Western Dietary Patterns: Beyond the health benefits of the Mediterranean Diet Author's response to reviews Title:Environmental footprints of Mediterranean versus Western Dietary Patterns: Beyond the health benefits of the Mediterranean Diet Authors: Sara Sáez Almendros (sara.saez.almendros@gmail.com)

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Comparison of two Bayesian methods to detect mode effects between paper-based and computerized adaptive assessments: A preliminary Monte Carlo study Authors: Barth B.

More information

Title:Impaired renal function and associated risk factors in newly diagnosed HIV-infected Adults in Gulu Hospital, Northern Uganda

Title:Impaired renal function and associated risk factors in newly diagnosed HIV-infected Adults in Gulu Hospital, Northern Uganda Author's response to reviews Title:Impaired renal function and associated risk factors in newly diagnosed HIV-infected Adults in Gulu Hospital, Northern Uganda Authors: Pancras Odongo (odongopancras@gmail.com)

More information

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (see an example) and are provided with free text boxes to

More information

Title: Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study

Title: Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study Author s response to reviews Title: Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study Authors: Jin Young Nam (jynam@yuhs.ac) Juyoung Kim

More information

RE: Title: Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis

RE: Title: Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis September 10, 2018 Professor Xue-Jiao Wang, MD Science Editor Editorial Office 'World Journal of Gastroenterology' RE: 40814 Title: Practical fecal calprotectin cut-off value for Japanese patients with

More information

Title: What 'outliers' tell us about missed opportunities for TB control: a cross-sectional study of patients in Mumbai, India

Title: What 'outliers' tell us about missed opportunities for TB control: a cross-sectional study of patients in Mumbai, India Author's response to reviews Title: What 'outliers' tell us about missed opportunities for TB control: a cross-sectional study of patients in Authors: Anagha Pradhan (anp1002004@yahoo.com) Karina Kielmann

More information

Hypomagnesemia May Lead to Insulin Resistance

Hypomagnesemia May Lead to Insulin Resistance Hypomagnesemia May Lead to Insulin Resistance Nutritional Biochemistry NDFS 435 21 February 2013 Heidi Washburn Dr. Parker Hypomagnesaemia has been associated with increased insulin resistance. It is thought

More information

Title: Socioeconomic conditions and number of pain sites in women

Title: Socioeconomic conditions and number of pain sites in women Author's response to reviews Title: Socioeconomic conditions and number of pain sites in women Authors: Finn E Skjeldestad (fisk@fhi.no) Toril Rannestad (Toril.Rannestad@hist.no) Version: 2 Date: 17 January

More information

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW. Adrian Barnett Queensland University of Technology, Australia 10-Oct-2014

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW. Adrian Barnett Queensland University of Technology, Australia 10-Oct-2014 PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

Title: Epidemiology of breast cancer in Cyprus: a population based case control study

Title: Epidemiology of breast cancer in Cyprus: a population based case control study Author's response to reviews Title: Epidemiology of breast cancer in Cyprus: a population based case control study Authors: Andreas Hadjisavvas (ahsavvas@cing.ac.cy) Maria A Loizidou (loizidou@cing.ac.cy)

More information

Amare Nigatu

Amare Nigatu Author s response to reviews Title: Self-reported acute pesticide intoxication in Ethiopia. Authors: Amare Nigatu (Amare.Nigatu@uib.no;Amare.Nigatu@igs.uib.no) Magne Bråtveit (Magne.Bratveit@uib.no) Bente

More information

VARIED THRUSH MANUSCRIPT REVIEW HISTORY REVIEWS (ROUND 2) Editor Decision Letter

VARIED THRUSH MANUSCRIPT REVIEW HISTORY REVIEWS (ROUND 2) Editor Decision Letter 1 VARIED THRUSH MANUSCRIPT REVIEW HISTORY REVIEWS (ROUND 2) Editor Decision Letter Thank you for submitting your revision to the Journal of Consumer Research. The manuscript and the revision notes were

More information

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers.

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Author's response to reviews Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and Authors: Helen Cavanagh (helen21987@hotmail.com) Katherine MA Rogers (k.rogers@qub.ac.uk) Version:3Date:1

More information

Title:Chlamydia trachomatis infection rates among a cohort of mobile soldiers stationed at Fort Bragg, North Carolina,

Title:Chlamydia trachomatis infection rates among a cohort of mobile soldiers stationed at Fort Bragg, North Carolina, Author's response to reviews Title:Chlamydia trachomatis infection rates among a cohort of mobile soldiers stationed at Fort Bragg, North Carolina, 2005-2010. Authors: Shilpa Hakre (shakre@hivresearch.org)

More information

Title: Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study

Title: Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study Author's response to reviews Title: Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study Authors: Delia Goletti (d.goletti@tiscali.it)

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Validation of Doloplus-2 among nonverbal nursing home patients - An evaluation of Doloplus-2 in a clinical setting An evaluating of Doloplus-2 in a clinical setting

More information

Standards for the reporting of new Cochrane Intervention Reviews

Standards for the reporting of new Cochrane Intervention Reviews Methodological Expectations of Cochrane Intervention Reviews (MECIR) Standards for the reporting of new Cochrane Intervention Reviews 24 September 2012 Preface The standards below summarize proposed attributes

More information

Title: Identifying work ability promoting factors for home care aides and assistant nurses

Title: Identifying work ability promoting factors for home care aides and assistant nurses Author's response to reviews Title: Identifying work ability promoting factors for home care aides and assistant nurses Authors: Agneta Larsson (agneta.larsson@ltu.se) Lena Karlqvist (lena.karlqvist@ltu.se)

More information

Reviewer: 1 Comment Response Comment Response Comment Response Comment Response

Reviewer: 1 Comment Response Comment Response Comment Response Comment Response Reviewer: 1 This paper reports a Mendelian randomisation study of LDL cholesterol on endpoints including Alzheimer's dementia and Parkinson's disease. Low LDL levels are causally associated with reduced

More information

MATERNAL INFLUENCES ON OFFSPRING S EPIGENETIC AND LATER BODY COMPOSITION

MATERNAL INFLUENCES ON OFFSPRING S EPIGENETIC AND LATER BODY COMPOSITION Institute of Medicine & National Research Council Food and Nutrition Board & Board on Children, Youth & Families Examining a Developmental Approach to Childhood Obesity: The Fetal & Early Childhood Years

More information

Scientific Editing Report

Scientific Editing Report Acknowledge editing support International publication guidelines such as ICMJE guidelines state that all non-author contributions, including editing, should be acknowledged. If you are satisfied with the

More information

Title:Bounding the Per-Protocol Effect in Randomized Trials: An Application to Colorectal Cancer Screening

Title:Bounding the Per-Protocol Effect in Randomized Trials: An Application to Colorectal Cancer Screening Author's response to reviews Title:Bounding the Per-Protocol Effect in Randomized Trials: An Application to Colorectal Cancer Screening Authors: Sonja A Swanson (sswanson@hsph.harvard.edu) Oyvind Holme

More information

Title:Video-confidence: a qualitative exploration of videoconferencing for psychiatric emergencies

Title:Video-confidence: a qualitative exploration of videoconferencing for psychiatric emergencies Author's response to reviews Title:Video-confidence: a qualitative exploration of videoconferencing for psychiatric emergencies Authors: Marianne V Trondsen (marianne.trondsen@telemed.no) Stein Roald Bolle

More information

Term Paper Step-by-Step

Term Paper Step-by-Step Term Paper Step-by-Step As explained in the Syllabus, each student will submit an 6-8 page (1250-2000 words) paper that examines and discusses current thinking in psychology about explanations and treatments

More information

Title: Increased incidence of traffic accidents in RhD-negative, Toxoplasma gondii-infected military drivers revealed by a prospective cohort study

Title: Increased incidence of traffic accidents in RhD-negative, Toxoplasma gondii-infected military drivers revealed by a prospective cohort study Author's response to reviews Title: Increased incidence of traffic accidents in RhD-negative, Toxoplasma gondii-infected military drivers revealed by a prospective cohort study Authors: Jaroslav Flegr

More information

Response: We thank the reviewer for his thoughtful and thorough review and believe his input has been invaluable to make our review more balanced

Response: We thank the reviewer for his thoughtful and thorough review and believe his input has been invaluable to make our review more balanced Response to Reviewers Editors 1. Thank you for your work in revising your paper, and patience while we have sent it back out for review and discussed it among the editorial team. Editors feel it sets out

More information

Title: Healthy snacks at the checkout counter: A lab and field study on the impact of shelf arrangement and assortment structure on consumer choices

Title: Healthy snacks at the checkout counter: A lab and field study on the impact of shelf arrangement and assortment structure on consumer choices Author's response to reviews Title: Healthy snacks at the checkout counter: A lab and field study on the impact of shelf arrangement and assortment structure on consumer choices Authors: Ellen van Kleef

More information

Standards for reporting Plain Language Summaries (PLS) for Cochrane Diagnostic Test Accuracy Reviews (interim guidance adapted from Methodological

Standards for reporting Plain Language Summaries (PLS) for Cochrane Diagnostic Test Accuracy Reviews (interim guidance adapted from Methodological s for reporting Plain Language Summaries (PLS) for Cochrane Diagnostic Test Accuracy Reviews (interim guidance adapted from Methodological Expectations of Cochrane Intervention Reviews (MECIR) guidance

More information

Below, we included the point-to-point response to the comments of both reviewers.

Below, we included the point-to-point response to the comments of both reviewers. To the Editor and Reviewers: We would like to thank the editor and reviewers for careful reading, and constructive suggestions for our manuscript. According to comments from both reviewers, we have comprehensively

More information

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL) PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

RESPONSE TO DECISION LETTER

RESPONSE TO DECISION LETTER RESPONSE TO DECISION LETTER Dear Editor-in-chief, We are grateful to the editors and reviewers for their time and constructive comments on our manuscript. We have implemented their comments and suggestions

More information

Title: Quality of life in childhood epilepsy with lateralized focus

Title: Quality of life in childhood epilepsy with lateralized focus Author's response to reviews Title: Quality of life in childhood epilepsy with lateralized focus Authors: Krystyna A. Mathiak (krystyna.mathiak@psych.uw.edu.pl) Malgorzata Luba (malgosia.luba@gmail.com)

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled

More information

Title: Vitamin D Receptor Gene Associations with Pulmonary Tuberculosis in a Tibetan Chinese population

Title: Vitamin D Receptor Gene Associations with Pulmonary Tuberculosis in a Tibetan Chinese population Author s response to reviews Title: Vitamin D Receptor Gene Associations with Pulmonary Tuberculosis in a Tibetan Chinese population Authors: Qunying Hu (huqunying15@163.com) Zhengshuai Chen (zshuaichen@163.com)

More information

CS2220 Introduction to Computational Biology

CS2220 Introduction to Computational Biology CS2220 Introduction to Computational Biology WEEK 8: GENOME-WIDE ASSOCIATION STUDIES (GWAS) 1 Dr. Mengling FENG Institute for Infocomm Research Massachusetts Institute of Technology mfeng@mit.edu PLANS

More information

Title: Prognostic factors for non-success in patients with sciatica and disc herniation

Title: Prognostic factors for non-success in patients with sciatica and disc herniation Author's response to reviews Title: Prognostic factors for non-success in patients with sciatica and disc herniation Authors: Anne J Haugen (annhau@so-hf.no) Jens I Brox (j.i.brox@medisin.uio.no) Lars

More information

TABLE OF CONTENTS. Introduction

TABLE OF CONTENTS. Introduction TABLE OF CONTENTS Introduction Level 5 exemplar 1 Level 5 exemplar 2 Level 4 exemplar 1 Level 4 exemplar 2 Level 3 exemplar 1 Level 3 exemplar 2 Level 2 exemplar 1 Level 2 exemplar 2 Level 1 exemplar 1

More information

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly Manuscript EMBO-2015-91176 Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly Camino De Juan Romero, Carl Bruder, Ugo Tomasello, Jose Miguel Sanz-Anquela

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Wnt1 is epistatic to Id2 in modeling mammary gland development and in causing mammary tumors Authors: Susan Marino (smarino@cmgm.stanford.edu) Claire Romelfanger (clairefrog@yahoo.com)

More information

Title: Co-morbidities, complications and causes of death among people with femoral neck fracture - A three-year follow-up study.

Title: Co-morbidities, complications and causes of death among people with femoral neck fracture - A three-year follow-up study. Author s response to reviews Title: Co-morbidities, complications and causes of death among people with femoral neck fracture - A three-year follow-up study. Authors: Monica Berggren (monica.langstrom@umu.se)

More information

BMJ - Decision on Manuscript ID BMJ

BMJ - Decision on Manuscript ID BMJ BMJ - Decision on Manuscript ID BMJ.2017.040049 Body: 14-Sep-2017 Dear Dr. Jaja Manuscript ID BMJ.2017.040049 entitled "Development and external validation of outcome prediction models for aneurysmal subarachnoid

More information

Title: The Limitations of Voluntary Medical Male Circumcision and the Importance of Sustained Condom Use: A Kenyan Newspaper Analysis

Title: The Limitations of Voluntary Medical Male Circumcision and the Importance of Sustained Condom Use: A Kenyan Newspaper Analysis Author's response to reviews Title: The Limitations of Voluntary Medical Male Circumcision and the Importance of Sustained Condom Use: A Kenyan Newspaper Analysis Authors: Charlene N Muzyka (charlene.muzyka@gmail.com)

More information

Title: Depression in Medical Students: insights from a longitudinal study

Title: Depression in Medical Students: insights from a longitudinal study Author s response to reviews Title: Depression in Medical Students: insights from a longitudinal study Authors: Vanessa Silva (avcrsilva@gmail.com) Patricio Costa (pcosta@ecsaude.uminho.pt) Inês Pereira

More information

Title: Use of Beta-blockers and Mortality Following Ovarian Cancer Diagnosis: A Population-Based Cohort Study

Title: Use of Beta-blockers and Mortality Following Ovarian Cancer Diagnosis: A Population-Based Cohort Study Author's response to reviews Title: Use of Beta-blockers and Mortality Following Ovarian Cancer Diagnosis: A Population-Based Cohort Study Authors: Sigrun A Johannesdottir (saj@dce.au.dk) Morten Schmidt

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1 Authors: J.

More information

PEER REVIEW HISTORY ARTICLE DETAILS

PEER REVIEW HISTORY ARTICLE DETAILS PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers.

Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Author's response to reviews Title:The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Authors: Helen Cavanagh (helen21987@hotmail.com) Katherine MA Rogers (k.rogers@qub.ac.uk)

More information

Title: Built environment and physical activity: domain- and activity-specific associations among Brazilian adolescents

Title: Built environment and physical activity: domain- and activity-specific associations among Brazilian adolescents Author s response to reviews Title: Built environment and physical activity: domain- and activity-specific associations among Brazilian adolescents Authors: Inacio da Silva (inacio_cms@yahoo.com.br) Adriano

More information

TITLE. Author name Author address (school address) INTRODUCTION

TITLE. Author name Author address (school address) INTRODUCTION SCIENTIFIC WRITING Dr. Craig 5/5/12 Skillful scientific writing involves using precise, concise language. Use primarily the first person and active voice (e.g. I conducted the trials, not the trials were

More information

Enclosed you will find our revised manuscript, entitled Sunlight for better or for worse?. One version with, one without track changes.

Enclosed you will find our revised manuscript, entitled Sunlight for better or for worse?. One version with, one without track changes. Noordwijk, 03-02-2016 Dear Editor, Enclosed you will find our revised manuscript, entitled Sunlight for better or for worse?. One version with, one without track changes. In response to the reviewers constructive

More information

Title: Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization

Title: Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization Author s response to reviews Title: Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization Authors: Margarita Riera-Montes (margarita.riera@p-95.com)

More information

Title:Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study

Title:Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study Author's response to reviews Title:Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study Authors: Anne Stine Kvehaugen (akvehaugen@yahoo.no)

More information

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW

PEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW PEER REVIEW HISTORY BMJ Paediatrics Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form and are provided with free text boxes to elaborate

More information

논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기

논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기 Apr 28, 2018 9:20-9:40 JGO Workshop 논문투고및투고후소통하기 : 영문교정작업, 실제논문투고하기, revision 답변달기, query form 작성하기 연세의대이정윤 좋은아이디어를얻기위하여, 타인으로부터유익한암시를받을때가있음. 새로운아이디어는두사람이상의지식및아이디어를함께모을때생겨나는경우가있음. 토론은잘못의발견에유익한방법임. 혼자독립하여동료와이야기를나누지않는연구자는틀린길을걸어가다많은시간을낭비하게되는경우가있음.

More information

Author's response to reviews

Author's response to reviews Author's response to reviews Title: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection

More information

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL)

PEER REVIEW HISTORY ARTICLE DETAILS TITLE (PROVISIONAL) PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/checklist.pdf)

More information

Answer to Anonymous Referee #1: Summary comments

Answer to Anonymous Referee #1:  Summary comments Answer to Anonymous Referee #1: with respect to the Reviewer s comments, both in the first review and in the answer to our answer, we believe that most of the criticisms raised by the Reviewer lie in the

More information

Title:Mixed-strain Housing for Female C57BL/6, DBA/2, and BALB/c Mice: Validating a Split-plot Design that promotes Refinement and Reduction

Title:Mixed-strain Housing for Female C57BL/6, DBA/2, and BALB/c Mice: Validating a Split-plot Design that promotes Refinement and Reduction Author's response to reviews Title:Mixed-strain Housing for Female C57BL/6, DBA/2, and BALB/c Mice: Validating a Split-plot Design that promotes Refinement and Reduction Authors: Michael Walker Mr (mwalk04@uoguelph.ca)

More information

Title: High muscular fitness has a powerful protective cardiometabolic effect in adults: Influence of weight status

Title: High muscular fitness has a powerful protective cardiometabolic effect in adults: Influence of weight status Author s response to reviews Title: High muscular fitness has a powerful protective cardiometabolic effect in adults: Influence of weight status Authors: Robinson Ramírez-Vélez (robin640@hotmail.com) Jorge

More information