The use of mobile-device data to better estimate dynamic population size for wastewater-based epidemiology
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1 Supporting Information for: The use of mobile-device data to better estimate dynamic population size for wastewater-based epidemiology Kevin V. Thomas a,b, Arturo Amador c, Jose Antonio Baz-Lomba a, Malcolm Reid a a Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-349 Oslo, Norway b Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 39 Keesels Road, Coopers Plains, Queensland, 418 Australia c Telenor ASA, Snarøyveien 3, NO-136 Fornebu, Norway
2 SI 1. Instrumental parameters for analysis of illicit drugs and pharmaceutical Chromatographic separation was carried out using a Waters Acquity UPLC BEH C8 column, 1.7µm, 2.1 x 1 mm (Milford, MA, USA). The column temperature was kept at C and the temperature of the sample manager was 4 C. A constant flow rate of.4 ml min -1 was used with a mobile phase consisting of.1% ammonium hydroxide (solvent A) and acetonitrile (solvent B). The elution gradient changed as follows: min (3% B); 4.9 min (3% B);.1 min (4% B); 8. min (6% B); 9 min (9% B); 1 min (9% B); 1. min (3% B); 11 min (3% B). The sample injection volume was 37 µ. LC MS/MS parameters using Waters Acquity UPLC system (Milford, MA, USA) coupled to a Waters Quattro Premier XE Micromass triple quadrupole mass spectrometer (Milford, MA, USA) with a T- wave collision cell and electrospray ionization interface (ESI), operated in positive ionization mode. The cone and desolvation gas used was nitrogen with flow rates of L hr -1 and 8 L hr -1, respectively. The collision gas used was argon with a flow rate of.1 ml min -1. Other operational parameters were capillary voltage, 3.2 kv; source temperature, 1 C and desolvation temperature, 4 C. Table SI 1. MS/MS optimized conditions for selected compounds. Quantitation Confirmation Compound Retention time MRM (Q1 > Q3) Cone (V) Collision (V) MRM (Q1 > Q3) Amphetamine > >118 Amphetamine-d > Methamphetamine > >118 Methamphetamine-d > MDMA > >14 MDMA-d > Cocaine > >1 Cocaine-d > Benzoylecgonine > >14 Benzoylecgonine-d > Cocaethylene > >82.1 Cocaethylene-d > Atenolol > ,2>14 Atenolol-d > Carbamazepine > >192.1 Citalopram > >19.2 Fexofenadine > > Fexofenadine-d > Methylphenidate > >174.1 Metoprolol > >191 Metoprolol-d > Lidocaine > > 8.1 Lidocaine-d >
3 Table SI 2. Method validation results in influent wastewater. Wastewater Relative recovery (RSD) Absolute recovery (RSD) Repeatibility (RSD) Matrix Effects LOQ Both in % Both in % % % ng L -1 [1 ng L -1 ] n=3 [1 ng L -1 ] n=3 [2 ng L -1 ] n=6 n=3 ILIS used for correction Amphetamine 1 (14) 36 (18) Amphetamine-d8 Methamphetamine 94 (1) 9 (3) Methamphetamine-d11 MDMA 99 (3) 86 () MDMA-d Cocaine 11 (8) 79 (1) Cocaine-d3 Benzoylecgonine 13 () 86 (14) Benzoylecgonine-d3 Cocaethylene 98 (3) 86 (1) Cocaethylene-d3 Atenolol 14 (12) 87 (3) Atenolol-d7 Citalopram 92 (1) 87 (7) Cocaethylene-d3 Carbamazepine 14 (9) 93 (1) Metoprolol-d7 Fexofenadine 96 (8) 9 (12) Fexofenadine-d6 Methylphenidate 1 (7) 91 (11) Cocaine-d3 Metoprolol 19 (16) 94 (3) Metoprolol-d7 Lidocaine 1 (3) 92 () Lidocaine-d6
4 2 Absolute and population-normalised loads of cocaine in Population Normalized Loads - mg/day/1 people Figure S1. Absolute and population-normalised loads of cocaine in Absolute and population-normalised loads of cocaethylene in Population Normalized Loads - mg/day/1 people Figure S2. Absolute and population-normalised loads of cocaethylene in
5 3 Absolute and population-normalised loads of citalopram in Population Normalized Loads - mg/day/1 people Figure S3. Absolute and population-normalised loads of citalopram in Absolute and population-normalised loads of atenolol in Population Normalized Loads - mg/day/1 people Figure S4. Absolute and population-normalised loads of atenolol in
6 8 7 Absolute and population-normalised loads of fexofenidine in Population Normalized Loads - mg/day/1 people Figure S. Absolute and population-normalised loads of fexofenidine in 14 Absolute and population-normalised loads of lidocaine in Population Normalized Loads - mg/day/1 people Figure S6. Absolute and population-normalised loads of lidocaine in
7 Absolute and population-normalised loads of methylphenidate in Population Normalized Loads - mg/day/1 people Figure S7. Absolute and population-normalised loads of methylphenidate in Absolute and population-normalised loads of carbamazepine in Population Normalized Loads - mg/day/1 people Figure S8. Absolute and population-normalised loads of carbamazepine in
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