Properties of Nerve Fibres. Dr. Ayisha Qureshi Professor MBBS, MPhil

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1 Properties of Nerve Fibres Dr. Ayisha Qureshi Professor MBBS, MPhil

2 1. PROPAGATION OF AN ACTION POTENTIAL

4 Does the action potential become weak (decremental) as it travels down the nerve fiber?

5 Does the action potential become weak (decremental) as it travels down the nerve fiber? NO, the action potential does NOT become weak as it travels down the nerve fiber. In fact, the AP does NOT travel down the nerve fiber but triggers a NEW AP in every new part of the membrane. It is like a wave at a stadium. Each section of spectators stands up (the rising phase of an action potential), then sits down (the falling phase) in sequence one after another as the wave moves around the stadium. The wave, not individual spectators, travels around the stadium. Thus, the last action potential at the end of the axon is identical to the original one, no matter how long the axon is. In this way, action potentials can serve as long-distance signals without becoming weak or distorted or decremental.

6 2. CONDUCTION OF AP IN A MYELINATED & UNMYELINATED NERVE FIBRE:

7 Which do you think has a faster rate of AP conduction myelinated or unmyelinated axons?

8 Continuous Conduction in Unmyelinated fibers Point to Point Continuous conduction occurs in unmyelinated axons. In this situation, the wave of de- and repolarization simply travels from one patch of membrane to the next adjacent patch.

9 Saltatory Conduction in Myelinated fibres In a Myelinated Nerve Fibre an Action Potential travels by SALTATORY Conduction, which is in a jumping manner from one Node of Ranvier to the next Node of Ranvier. Saltatory conduction is faster because the current leak is minimized. The unmyelinated axon has low resistance to current leak because the entire axon membrane is in contact with the extracellular fluid and has ion channels through which current can leak.

11 Which do you think has a faster rate of AP conduction myelinated or unmyelinated axons? Myelinated Axon

12 Myelination increases speed of nerve impusle conduction Action potentials race along myelinated nerve fibres at rates of up to 100 metres/second or more, while in unmyelinated fibers they have a speed of 1 metre/second only. Very, very important!

13 3. CONDUCTION OF AP IN A LARGE & SMALL DIAMETER NERVE FIBER

14 Which do you think would conduct an AP faster: an axon with a large diameter or an axon with a small diameter?

15 Which do you think would conduct an AP faster: an axon with a large diameter or an axon with a small diameter? Axon with a large diameter.

16 4. ALL OR NONE LAW

17 ALL OR NONE LAW (also called the All or Nothing Law) On application of a stimulus, an excitable membrane either responds with a maximal or full-fledged action potential that spreads along the nerve fiber, or it does not respond with an action potential at all. This property is called the all-or-none law. (This is in direct proportion to the strength of the stimulus applied.) e.g: This is similar to firing a gun. Either the trigger is NOT pulled sufficiently to fire the gun (subthreshold stimulus) OR it is pulled hard enough to fire the gun (threshold is reached). Squeezing the trigger harder does not produce a greater explosion, just as pulling the trigger halfway does not cause the gun to fire halfway.

18 Some Action Potential Questions 1. Can you ever have ½ an AP? 2. Will one AP ever be bigger than another? Why or why not? 3. If all action potentials are the same, how does the neuron transmit information about the strength and duration of the stimulus that started the action potential?

19 Because all action potentials are the same, the CNS differentiates between the strength of different stimuli by the frequency of the action potentials. The more the number of action potentials, the stronger the stimulus. Similarly, the duration can be known by the simple fact: as long as the action potentials are firing, the stimulus is still there.

21 5. Refractory period: Once an Action Potential has begun, a second action potential cannot be started. It is of 2 main types: - ABSOLUTE REFRACTORY PERIOD - RELATIVE REFRACTORY PERIOD

22 ABSOLUTE REFRACTORY PERIOD Definition: Once an action potential has begun, the time period during which even a suprathreshold stimulus will fail to produce a new action potential is called the Absolute Refractory period. During this time the membrane becomes completely refractory ( unresponsive ) to any further stimulation. It is the entire Depolarization phase & most of the Repolarization phase. ADVANTAGE: Due to Absolute refractory period, one AP must be over before another can be initiated at the same site. A second action potential cannot occur before the first has finished, thus, action potentials moving from trigger zone to axon terminal CANNOT overlap and CANNOT travel backward.

23 BASIS OF AN ABSOLUTE REFRACTORY PERIOD: During the depolarization phase of AP, the voltagegated Sodium channels have still NOT reset to their original position. For the Sodium channels to respond to a stimulus, 2 events are important: 1. Sodium channels be reset to their resting position. i.e: inactivation gates open and activation gates closed. 2. The Resting membrane potential must be reestablished.

24 Relative Refractory Period Definition: During an action potential, there is a short duration of time during which a second action potential CAN be produced, if the triggering event is a suprathreshold stimulus. This period is called the Relative Refractory Period. It corresponds to the last half of the Repolarization phase.

25 Basis of a Relative Refractory Period: An action potential can be produced by a suprathreshold stimulus because of the following reasons: 1. By the end of repolarization phase, some Na channels have reset. These Na channels will respond to a larger than normal stimulus. 2. Thus, a greater than normal triggering event (suprathreshold stimulus) is required to produce an AP.

27 In this figure, what do the red and blue box represent? V M TIME

28 What is the significance of the REFRACTORY PERIOD (both absolute & relative): 1. It sets an upper limit on the maximum numbers of APs that can be produced in a nerve fibre in a given period of time. 2. It prevents fatigue in a nerve fibre. This intermittent, (ie. Not continuous) conduction of nerve impulses is one of the reasons why a nerve fibre can respond to continuous stimulation for hours without getting tired. 3. A new AP is produced in each part of the nerve fibre. This ensures that the AP does not die out as it is conducted along the membrane. 4. The absolute refractory period also ensures one-way travel of an action potential from cell body to axon terminal by preventing the action potential from traveling backward.

29 6. COMPOUND ACTION POTENTIAL:

31 Compound Action Potential is seen in a nerve trunk & NOT a nerve fibre: An action potential having more than one peak/spike is called a Compound action potential. CAUSE: A nerve trunk contains many nerve fibres differing widely in their excitability & different speeds of conduction of AP. Multiple peaks are recorded with the AP from fastest conducting nerve fibre first to be recorded followed by the slower ones...

32 Strength duration curve is obtained by plotting the voltage (current strength) of the stimulus against the duration of the stimulus. STRENGTH DURATION CURVE

34 Rheobase: It is the minimum voltage value of the stimulus which when applied for an adequately prolonged time will give rise to an action potential. Utilization time: It is the time needed by the threshold stimulus (rheobase) to give a response. Chronaxie: It is the minimum duration for which a stimulus equal to twice the Rheobase value has to be applied in order to be effective in obtaining a response. (Chronaxie is a measure of excitability: Tissues which are more excitable will have a shorter chronaxie and vice versa.)

35 PROPERTIES OF AN ACTION POTENTIAL 1. Propagation of an AP 2. Conduction in myelinated & Unmyelinated fibres. 3. Conduction in large and small diameter fibres. 4. All or none Law. 5. Absolute & Relative Refractory period. 6. Compound Action Potential. 7. Strength duration curve

Nerve. (2) Duration of the stimulus A certain period can give response. The Strength - Duration Curve

Nerve. (2) Duration of the stimulus A certain period can give response. The Strength - Duration Curve Nerve Neuron (nerve cell) is the structural unit of nervous system. Nerve is formed of large numbers of nerve fibers. Types of nerve fibers Myelinated nerve fibers Covered by myelin sheath interrupted