Faiez Zannad, MD, PhD, Nancy
|
|
- Melissa Johnston
- 6 years ago
- Views:
Transcription
1 1
2 Biotargets, drug discovery and therapeutic innovation. How French clinical networks can accelerate the discovery of new treatments in the field of cardiovascular and metabolic diseases? Faiez Zannad, MD, PhD, Nancy
3 The network of Clinical Investigation Centers CARDIOVASCULAR Bichat Robert Debré Garches Saint-Louis Lille Necker Enfants Malades HEGP HEGP Cochin Pasteur Les Pitié- Salpêtrière Saint- Antoine Henri Mondor (94 Créteil) Brest Rennes Rouen Nancy Besançon Strasbourg IGR/Curie (Villejuif/Paris) Nantes Tours Dijon Poitiers Pointe-à-Pitre CIC-P (27) CIC-EC (9) Limoges Bordeaux Lyon Clermont- Ferrand Saint-Etienne Grenoble CIC-BT (10) Fort-de-France CIC-IT (8) Toulouse Montpellier Marseille Cayenne Ile de la Réunion
4 The network of Clinical Investigation Centers DIABETES and METABOLIC DISORDERS UMR6061 U620 U522 Rennes EMI9920 EMI9906 U921 Rouen Tours Ile de la Réunion Saint-Pierre Bordeaux Lille Bichat U545 U530 Robert Debré U690 U561 Saint- U383 Antoine U680 U695 Nancy Strasbourg U498 UR545 U499 U308 EMI586 UMR5232 U626 Toulouse Montpellier Marseille U476 U317 IRD U608 EA4188 ESPRI25
5 Academic resources within a basic research and sophisticated technological environment and with immediate access to patients in University Hospitals Databases COHORTS Clinical trials Biobanks Patient organisations Disease Management programs
6 International funding bodies and consortia, with specific schemes of partnering with Industry
7 One solution to coordinate multicenter (multiple countries) trials EDDH, an Academic Research Organisation Advisory Board Faiez Zannad Alain Leizorovicz Gilles Montalescot Gabriel Steg European Drug Development Hub Under the Aegis of a Foundation
8 Academic Research Organization Coordination of 16 cardiovascular CICs National network of technicians and Technical research nurses Experienced Working in hospitals, Physician s office, patient s home Network of private practice Physicians - research practicioners GPs Cardiologists Psychiatrists INSERM label standardized procedures professional clinical researchers EDDH
9 An Industry- Academic collaboration with the aim to Assist Investigators to enroll more patients in clinical trials
10 SUCCESS STORIES How French clinical networks can accelerate discovery in the field of cardiovascular and metabolic diseases? A new class of medication A new potential biomarker
11 Aldosterone blockade prevents myocardial fibrosis Fibrosis % Survival RALES: Trial based Evidence 30% reduction in risk P < Spironolactone Biomarker Substudy Confirms mechanism of action Placebo 0.40 No fibrosis Circulation.1991;83: N Engl J Med. 1999;341: Circulation 2000
12 New Trial in Post MI, New drug (Eplerenone) acquired by Pfizer EPHESUS Cumulative survival rate (%) ACS French Registry; Aldosterone levels at admission are associated with poor outcome. Log-rank p=0.005 Quartile 1 (lowest) Quartile 2 Quartile 3 Quartile 4 (highest) Days N Engl J Med. 2003
13 Twin trials ALBATROSS (academic) and REMINDER (Industry) STEMI, Anterior, LVEF > 40%, HF signs/symptoms, CK- MB>x or Troponin>y orbnp> z, Standard Therapy* Eplerenone 25 mg QD up to week 4 Randomize < 48 hours Placebo From onset of symptoms Primary end points: Death or (MRI) LVEF<30% within 30 days Secondary end points: All-cause mortality CV mortality Length of Stay
14 New drugs : Aldosterone inhibitors Genration Selectivity (sex side effects) potency Vasculra/renal effect Priamry Aldo Antiinflammatory First Spiro Second Eplerenone Third Non steroidal Fourth Non renal
15 Aldosterone inhibitors: Potential indications 1. Primary hyperaldosteronism 2. Glucocorticoid remediable aldosteronism (GRA) 3. Low renin/high aldosterone hypertension 4. Resistant hypertension 5. Congestive heart failure 6. Liver cirrhosis 7. Metabolic syndrome 8. High normal blood pressure
16 LCI699 (Aldo synthase inhibitor) in Patients With Primary aldosteronism : proof of concept study in the CIC CV network Design 4 week, Single-blind, Forced-titration Patients: Hypertensive patients with primary aldosteronism Objectives: to Assess the Hemodynamic and Hormonal Effects, Safety and Tolerability
17 Pharmacological postconditioning (Inhibition of mitochondrial permeability transition) INSERM Unité 886, Lyon Am J Physiol Heart Circ Physiol. 2007
18 From Bench to Bedside Pharmacological postconditioning Cyclosporine A Hôpital Arnaud de Villeneuve, Montpellier, Hospices Civils de Lyon, Service de Cardiologie, Mulhouse NEJM, 2008 PHRC CYCLADE, Post Surgical conditioning
19 Pro-M22: a new biomarker in acute heart failure Discovery: Validation Proteomics, human failing heart plasma of dyspneic patients BNP (ELISA) Pro-M22 (MS) S2 P2 S1 P1 Sensitivity Specificity AUC BNP: 0.86; AUC Pro-M22: 0.88 Pronota, Inserm, AP-HP, Paris 7 GREAT Network (15 countries) A Mebazaa, JL Samuel, A Cohen Solal et al U 942 Inserm
20
21 Derivation to Validation: CV CIC Network
22 The Stanislas Cohort 1006 families, 4295 subjects enrolled in the program 600 demographics and laboratory dataset values 117 original publications «Open access» to international scientific community Feasibility Visit 1 Visit 2 Visit 3 Visit Preventive Medicine Center and Clinical Investigation Center, Nancy
23 Genetic Epidemiology and Biobanks" Aortic stenosis genetics Probst et al, Circulation 2006 One common ancestor born in the XVIth century
24 SYNERGISM
EVATEL Study. Remote follow-up of patients implanted with an ICD The prospective randomized EVATEL study
EVATEL Study Remote follow-up of patients implanted with an ICD The prospective randomized EVATEL study Philippe Mabo, Pascal Defaye, Nicolas Sadoul, Jean Marc Davy, Jean-Claude Deharo, Salem Kacet, Eric
More informationDECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST Novel approaches in hypertension Aldosterone-synthase inhibitors. Faiez Zannad Nancy, France Disclosures Dr Zannad reports receiving Speaker/consultant honoraria from
More information*APHP: Hôpital Beaujon Professor P Bedossa, Dr F Degos, Professor P Marcellin, Professor
APPENDIX 1 LIST OF COINVESTIGATORS *APHP: Hôpital Beaujon Professor P Bedossa, Dr F Degos, Professor P Marcellin, Professor M Vidaud; Hôpital Cochin-Necker: Professor S Pol, Professor Ph Sogni, Professor
More informationFaiez Zannad. Institut Lorrain du Coeur et des Vaisseaux. CIC - Inserm
Faiez Zannad Institut Lorrain du Coeur et des Vaisseaux CIC - Inserm Disclosure Faiez Zannad Grants BG Medicine, Roche Diagnostics. Consultant/Steering committees/event committees/ Data safety Monitoring
More informationObesity, Inflammation and Liver Cancer
Obesity, Inflammation and Liver Cancer Richard Moreau, M.D., 1 INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, 2 Université Denis Diderot Paris 7, 3 Service d Hépatologie, Hôpital Beaujon,
More informationDevelopment of Geriatric Oncology in France
Development of Geriatric Oncology in France Pr Pierre Soubeyran Institut Bergonié, Bordeaux, France Epidemiology French population, 2013 9% older than 75 (10.9% females, 7% males) Number of cancer cases
More informationResearch in viral hepatitis: the French ANRS experience
PARIS HEPATITIS CONFERENCE January 14-15, 2013 Research in viral hepatitis: the French ANRS experience Pr. Jean-François DELFRAISSY Director of ANRS Internal Medicine Department CHU Bicêtre Paris XI -
More informationINI-CRCT (Cardiovascular and Renal Clinical Trialists) Coord: Prof. P. Rossignol, Nancy Inserm 9501 CIC
INI-CRCT (Cardiovascular and Renal Clinical Trialists) Coord: Prof. P. Rossignol, Nancy Inserm 9501 CIC CIC-INSERM, CHU de Nancy- Université de Lorraine UMR Inserm U 1116 Heart failure and Hypertension
More informationGenetic Counselling in a Pulmonary Hypertension Referral Center
Genetic Counselling in a Pulmonary Hypertension Referral Center Marc HUMBERT, MD, PhD DÉPARTEMENT DE Centre National de Référence de l Hypertension Pulmonaire Sévère Hôpital Bicêtre, Assistance Publique
More informationFUnctional Testing Underlying REvascularization The FUTURE trial
FUnctional Testing Underlying REvascularization The FUTURE trial Gilles Rioufol, François Roubille, Thibault Perret, Pascal Motreff, Denis Angoulvant, Yves Cottin, Ludovic Meunier,Nathan Mewton, Michel
More informationTrial and Cost Effectiveness Evaluation of Intra arterial Thrombectomy in Acute Ischemic Stroke
Trial and Cost Effectiveness Evaluation of Intra arterial Thrombectomy in Acute Ischemic Stroke S. Bracard, F. Guillemin, X. Ducrocq for the THRACE investigators Disclosure Personal: No disclosure Study
More informationIs stenting a safe and durable option in the common femoral artery?
Is stenting a safe and durable option in the common femoral artery? (TECCO randomized clinical trial, NCT01353651) Y. Gouëffic, N. Della Schiava, F. Thaveau, E. Rosset, J.P. Favre, L. Salomon du Mont,
More informationAdministration of research
Julian Tugaut Resume Experience 01/12/2015 Habilitation, Saint-Étienne. 2013 Associate Professor, Télécom - Institut Camille Jordan, Saint-Étienne (France). 2010 2013 Postdoc, Bielefeld (Germany). two
More informationPosition Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE
Position Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE Over 8,000 patients have been studied in two well-designed placebo-controlled outcome-driven clinical trials to evaluate the
More informationDrug eluting therapies: Just do it! Y. Gouëffic, MD, PhD Department of vascular surgery, University hospital of Nantes, France
Drug eluting therapies: Just do it! Y. Gouëffic, MD, PhD Department of vascular surgery, University hospital of Nantes, France Disclosure Speaker name: Yann Gouëffic X I have the following potential conflicts
More informationAldosterone Antagonism in Heart Failure: Now for all Patients?
Aldosterone Antagonism in Heart Failure: Now for all Patients? Inder Anand, MD, FRCP, D Phil (Oxon.) Professor of Medicine, University of Minnesota, Director Heart Failure Program, VA Medical Center 111C
More informationMolecular portraits/landscape of lung cancer in France
Molecular portraits/landscape of lung cancer in France Jean-Charles SORIA Frédérique NOWAK Fabien CALVO U981 2 Disclosure Slide Member of the SAB of the french NCI (INCA). Appointed by the Ministry of
More informationA randomized comparison of endovascular versus surgery treatment of common femoral artery disease: Results from the TECCO trial
A randomized comparison of endovascular versus surgery treatment of common femoral artery disease: Results from the TECCO trial (TECCO randomized clinical trial, NCT01353651) Y. Gouëffic, N. Della Schiava,
More informationSupplemental material
Supplemental material 1. Clinical trial steering committee 2. Independent data and safety monitoring committee 3. Contributors 4. List of other investigators and members of the GEMRITUX study group 5.
More informationThe BATTLE Trial Comparing Bare Metal to Drug Eluting Stents for Intermediate Length Lesions of the SFA
The BATTLE Trial Comparing Bare Metal to Drug Eluting Stents for Intermediate Length Lesions of the SFA BATTLE RCT investigators: Y. Gouëffic, A. Sauguet, P. Desgranges, P. Feugier, E. Rosset, E. Ducasse,
More informationRHU ivasc: CONSTANCES et la recherche cardiovasculaire. Ph.Gabriel STEG DHU FIRE Hôpital Bichat; AP-HP INSERM U1148 Université Paris Diderot
RHU ivasc: CONSTANCES et la recherche cardiovasculaire Ph.Gabriel STEG DHU FIRE Hôpital Bichat; AP-HP INSERM U1148 Université Paris Diderot ivasc: Innovations in atherothrombosis science Atherothrombosis:
More informationDECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST TAKE HOME MESSAGES FROM RECENT HEART FAILURE CLINICAL TRIALS How to use aldosterone blockers? Faiez Zannad INSERM, U961 and Clinical Investigation Center CHU, Heart
More informationRolling out personalised medicine for cancer in France
Rolling out personalised medicine for cancer in France Frédérique NOWAK Head of Department for Biology, Transfer & Innovations Institut National du Cancer (INCa) Personalised Medicine Conference 2016 1,2
More informationThe SEPTAL CRT study (NCT: )
Comparison of right ventricular septal pacing and right ventricular apical pacing in patients receiving cardiac resynchronization therapy defibrillators The SEPTAL CRT study (NCT: 00833352) Christophe
More informationHistorical perspective (2)
Experience from Public Health System : French CECOS experience Dominique ROYERE Médecine et Biologie de la Reproduction Cecos de Tours, France Historical perspective (2) To understand what was the context
More informationOptimal management of auto-immune
collaborations des équipes impliquées dans l' explorati en charge des ef ets indésirables des immunothérapies INSCRIPTIONS BLIC : cialistes d organe, Chercheur s, ovigilants ns l es toxicités es anti-cancéreuses.
More informationMISTRAL. Myocardial Infarction with ST-elevation Treated by Primary Percutaneous Intervention Facilitated by Early Reopro Administration in ALsace
Les Hôpitaux Universitaires de STRASBOURG MISTRAL Myocardial Infarction with ST-elevation Treated by Primary Percutaneous Intervention Facilitated by Early Reopro Administration in ALsace Pre-hospital
More informationRepositioning of the Mineralocorticoid Receptor Antagonists in renal diseases: pathophysiological basis and therapeutic issues
# 3 Frédéric Jaisser 1 MD, PhD Professor in Physiology, INSERM Head of the Department Integrative Physiology and Pathophysiology, Cordeliers Research Center, Paris, France Repositioning of the Mineralocorticoid
More informationGeographic Optimization of Liver Allocation in Transplantation
1 1 Geographic Optimization of Liver Allocation in Transplantation Esri Health GIS Conference Florian Bayer, Dr. Christian Jacquelinet, Benoit Audry, Dr. Corinne Antoine 2 2 a - Introduction Study Objectives
More informationSafety surveillance of influenza A(H1N1)v monovalent vaccines during the mass vaccination. campaign in France
Safety surveillance of influenza A(H1N1)v monovalent vaccines during the 2009-2010 mass vaccination campaign in France Céline Caillet, Genevieve Durrieu, Alexis Jacquet, Angeline Faucher, Scheherazade
More informationNew in Heart Failure SGK autumn session 2012
New in Heart Failure SGK autumn session 2012 Roger Hullin Cardiology Department of Internal Medicine Centre Universitaire Hospitaler Vaudois University of Lausanne ESC Heart Failure Guidelines 2012 Classes
More informationAldosterone synthase inhibitors. John McMurray BHF Cardiovascular Research Centre University of Glasgow
Aldosterone synthase inhibitors John McMurray BHF Cardiovascular Research Centre University of Glasgow Inhibition of aldosterone synthesis is hypothesized to be of benefit to patients with cardiovascular
More informationRIC-Mel Network - Network for Research and Clinical Investigation on Melanoma - French national cohort of
RIC-Mel Network - Network for Research and Clinical Investigation on Melanoma - French national cohort of melanoma patients Head : Pr Dreno Brigitte, INSERM Unité U892 Equipe 2 «Recherche clinique et translationnelle
More informationDoes heparin impregnated graft improve patency and reduce the cost of lower limb bypass? The REPLACE trial Y. Gouëffic, MD, PhD
Does heparin impregnated graft improve patency and reduce the cost of lower limb bypass? The REPLACE trial Y. Gouëffic, MD, PhD Department of vascular surgery, University hospital of Nantes, France Disclosure
More informationFrench Networks for Sarcoma and GIST. O Mir, JY Blay
French Networks for Sarcoma and GIST O Mir, JY Blay Introduction Since 2009 a network of 26 reference multidisciplinary centers aiming to improve the quality of care for sarcoma patients in France was
More informationTitle: Real-life use of inhaled corticosteroids in COPD patients vs. GOLD proposals: a paradigm shift in GOLD 2011?
ERJ Express. Published on October 31, 2013 as doi: 10.1183/09031936.00162313 Letter to the Editor Title: Real-life use of inhaled corticosteroids in COPD patients vs. GOLD proposals: a paradigm shift in
More informationThe study was sponsored by MSD
A Phase 3, French Multicenter, Open-Label Study to Investigate the Efficacy of Elbasvir/Grazoprevir Fixed-Dose Combination for 8 Weeks in Treatment-Naïve HCV GT1b-Infected Patients, with non-severe fibrosis
More informationF-CRIN, TOGETHER TO SUPPORT CLINICAL RESEARCH IN FRANCE
F-CRIN, TOGETHER TO SUPPORT CLINICAL RESEARCH IN FRANCE 1 F-CRIN : HOW AND WHY? A national and European challenge to Strengthen the most promising of French Clinical Research to Europe A structure funded
More informationSUPPLEMENTARY DATA. Telediab Study Group :
Telediab Study Group : Guillaume Charpentier, MD, Department of Diabetes, Sud-Francilien Hospital, Corbeil-Essonnes, France Centre d Études et de Recherches pour l Intensification du Traitement du Diabète
More informationA new look at left ventricular remodeling definition by cardiac imaging
A new look at left ventricular remodeling definition by cardiac imaging Loïc Bière, Erwan Donal, Alexis Jacquier, Pierre Croisille, Olivier Genée, Luc Christiaens, Fabrice Prunier, Pascal Gueret, Louis
More informationTP53 mutational profile in CLL : A retrospective study of the FILO group.
TP53 mutational profile in CLL : A retrospective study of the FILO group. Fanny Baran-Marszak Hopital Avicenne Bobigny France 2nd ERIC workshop on TP53 analysis in CLL, Stresa 2017 TP53 abnormalities :
More informationMedical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece
Medical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece Disclosures Grants: ALARM investigator received research grants
More informationESC Guidelines for the Diagnosis and Treatment of Chronic Heart Failure
ESC Guidelines for the Diagnosis and Treatment of Chronic Heart Failure - 2005 Karl Swedberg Professor of Medicine Department of Medicine Sahlgrenska University Hospital/Östra Göteborg University Göteborg
More informationBiomarkers for the diagnosis of emerging invasive fungal infections :
Biomarkers for the diagnosis of emerging invasive fungal infections : Challenges, Perspectives Example of Mucorales infections Laurence Millon Parasitologie-Mycologie, CHU Besançon UMR CNRS 3249 Chrono
More informationTreatment of Rare Cancers Academic perspective
Treatment of Rare Cancers Academic perspective JY Blay Medical Oncology, Lyon EORTC Eurosarc Issues Recognition Management Fragmentation Solutions Pathology review! Brussels 25 5 2012 Rate of concordance
More informationESC Guidelines for diagnosis and management of HF 2012: What s new? John Parissis, MD Athens, GR
ESC Guidelines for diagnosis and management of HF 2012: What s new? John Parissis, MD Athens, GR Disclosures ALARM INVESTIGATOR RESEARCH GRANTS BY ABBOTT USA AND ORION PHARMA The principal changes from
More informationDamien Logeart. Disclosure: none
Damien Logeart Disclosure: none 13/1/211 HEART FAILURE AND MYOCARDIOPATHIES Best of 21 Damien Logeart Hôpital Lariboisière, Paris Service Cardiologie INSERM U942 Cliquez pour modifier le style des sous-titres
More informationHeart Failure: Combination Treatment Strategies
Heart Failure: Combination Treatment Strategies M. McDonald MD, FRCP State of the Heart Symposium May 28, 2011 None Disclosures Case 69 F, prior MIs (LV ejection fraction 25%), HTN No demonstrable ischemia
More informationThe French national network of 28 hospital molecular genetics platforms: summary of the activity in 2009
Measure 21 care and life of patients The French national network of 28 hospital molecular genetics platforms: summary of the activity in 2009 COLLECTION reports & summaries ACCESS TO INNOVATIVE MOLECULAR
More informationAJRCCM Articles. Published on February 23, 2012
Fever Control Using External Cooling in Septic Shock: A Randomized Controlled Trial Frédérique Schortgen, Karine Clabault, Sandrine Katsahian, Jerome Devaquet, Alain Mercat, Nicolas Deye, Jean Dellamonica,
More informationDECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST Safety and Effectiveness of ICD Followup using Remote Monitoring ECOST Study (Effectiveness and Cost Of ICD follow-up Schedule with Telecardiology) Salem Kacet, Laurence
More informationWe are most delighted to welcome you in Paris.
10 th CardioVascular Clinical Trialists Workshop Paris, December 6 th, 2007 Board of Chairmen : Faiez ZANNAD (Nancy) Desmond JULIAN (London) Bertram PITT (Ann Arbor) David GORDON (Bethesda) Ray LIPICKY
More informationLong-Term Post Transplantation Care. Pathogenesis and Management of Long Term Cardiovascular and Metabolic Complications in Renal Transplantation
3 rd ERA-EDTA CME COURSE Long-Term Post Transplantation Care Pathogenesis and Management of Long Term Cardiovascular and Metabolic Complications in Renal Transplantation What the Non Transplant-Nephrologists
More informationThe Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery: The SYNTAX Study
The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery: The SYNTAX Study Five-Year Results in the French Subset René Koning, MD On behalf of the SYNTAX investigators Three-year
More informationCIC-P Nancy. Disclosures
Pr Patrick Rossignol Inserm 1433 Clinical Investigation Center Hypertension and Heart Failure Unit Association Lorraine pour le Traitement de l Insuffisance Rénale (ALTIR) CHRU, Lorraine University Nancy,
More informationPaul Calabresi Award. From suboptimal to optimal treatment in older patients with cancer. Pierre Soubeyran, MD, PhD
Paul Calabresi Award From suboptimal to optimal treatment in older patients with cancer Pierre Soubeyran, MD, PhD Institut Bergonié, Université Bordeaux Segalen Health status-adapted cancer care Balance
More informationTherapeutic Targets and Interventions
Therapeutic Targets and Interventions Ali Valika, MD, FACC Advanced Heart Failure and Pulmonary Hypertension Advocate Medical Group Midwest Heart Foundation Disclosures: 1. Novartis: Speaker Honorarium
More informationANRS CO12 CIRVIR - Prospective cohort involving patients with viral cirrhosis B and C
ANRS CO12 CIRVIR - Prospective cohort involving patients with viral cirrhosis B and C Head : Nahon Pierre, Service d'hépatologie, Hôpital Jean Verdier Roudot-thoraval Françoise, Service de santé publique,
More informationNo conflict of interest to declare
Switch and Non-Switch in P2Y12 Inhibition: The Real-Life Use of Clopidogrel and Prasugrel in Patients with Acute Myocardial Infarction. Insights from the FAST MI 2010 Registry. F. Schiele (Besançon), E.
More informationΚΑΡΔΙΑΚΗ ΑΝΕΠΑΡΚΕΙΑ ΚΑΙ ΑΝΤΑΓΩΝΙΣΤΕΣ ΑΛΔΟΣΤΕΡΟΝΗΣ ΣΠΥΡΟΜΗΤΡΟΣ ΓΕΩΡΓΙΟΣ MD, FESC. E.Α Κ/Δ Γ.Ν.ΚΑΤΕΡΙΝΗΣ
ΚΑΡΔΙΑΚΗ ΑΝΕΠΑΡΚΕΙΑ ΚΑΙ ΑΝΤΑΓΩΝΙΣΤΕΣ ΑΛΔΟΣΤΕΡΟΝΗΣ ΣΠΥΡΟΜΗΤΡΟΣ ΓΕΩΡΓΙΟΣ MD, FESC. E.Α Κ/Δ Γ.Ν.ΚΑΤΕΡΙΝΗΣ Aldosterone is a mineralocorticoid hormone synthesized by the adrenal glands that has several regulatory
More informationA patient with decompensated HF
A patient with decompensated HF Professor Michel KOMAJDA University Pierre & Marie Curie Pitie Salpetriere Hospital Department of Cardiology Paris (France) Declaration Of Interest 2010 Speaker : Servier,
More informationTiming of angiography for high- risk ACS
Timing of angiography for high- risk ACS Christian Spaulding, MD, PhD, FESC, FACC Cardiology Department Cochin Hospital, Inserm U 970 Paris Descartes University Paris, France A very old story. The Interventional
More informationWe re inventing the cancerology of tomorrow
We re inventing the cancerology of tomorrow UNICANCER GROUP OF THE FRENCH CANCER CENTRES Innovating together for patients UNICANCER unites all of the Cancer Centres in France: these private non-profit
More informationEmergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011.
Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011. Sophie Vaux, Anne Carbonne, Jean-Michel Thiolet, Vincent Jarlier, Bruno Coignard, the RAISIN and Expert Laboratories Group
More informationHFpEF, Mito or Realidad?
HFpEF, Mito or Realidad? Ileana L. Piña, MD, MPH Professor of Medicine and Epidemiology/Population Health Associate Chief for Academic Affairs -- Cardiology Montefiore-Einstein Medical Center Bronx, NY
More informationFlorian Bayer Dr. Christian Jacquelinet Benoit Audry
1 Using a gravity model for allocation o of livers to transplant Florian Bayer Dr. Christian Jacquelinet Benoit Audry 2 a -Introduction Study Objectives Global context : What can be the contribution of
More informationS. CHASSAING4 P. DEQUENNE5
#10899 - OP013 Importance of delay for management of STEMI: does the helicopter HEMS is better than ground transport with MICU ambulance? Analyze of the French region Centre Registry of Acute Coronary
More informationST2 in Heart Failure. ST2 as a Cardiovascular Biomarker. Competitive Model of ST2/IL-33 Signaling. ST2 and IL-33: Cardioprotective
ST2 as a Cardiovascular Biomarker Lori B. Daniels, MD, MAS, FACC Professor of Medicine Director, Coronary Care Unit University of California, San Diego ST2 and IL-33: Cardioprotective ST2: member of the
More informationI have the following potential conflicts of interest to report: Other(s): Proctor for Medtronic for TAVI cases using the CoreValve/Evolut R devices
Transcatheter aortic valve implantation for failed surgical aortic bioprostheses using a selfexpanding device: early results from the prospective VIVA post-market study Prof. Ran Kornowski, Rabin Medical
More informationDES in primary PCI for STEMI: contra
DES in primary PCI for STEMI: contra Philippe Gabriel Steg Department of Cardiology Hôpital Bichat Claude Bernard, AP-HP Université Paris VII Denis Diderot INSERM U-698 Paris, France Ph. Gabriel Steg -
More informationN.U.A.G.E.S: A survey of nebulisation practice in France with regard to ERS guidelines
Respiratory Medicine (2007) 101, 2561 2565 SHORT COMMUNICATION N.U.A.G.E.S: A survey of nebulisation practice in France with regard to ERS guidelines M. de Monte a, J. Scruignec a, J.C. Dubus b,c, J.P.
More informationL Bonello, L Camoin-Jau, S Arques, C Boyer, D Panagides, O Wittenberg, MC Siméoni, P Barragan, F Dignat-George, F Paganelli.
Adjusted Clopidogrel Loading Doses According to VASP Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel low response: A Multicentre Randomized Prospective
More informationThe benefit of treatment with -blockers in heart failure is
Heart Rate and Cardiac Rhythm Relationships With Bisoprolol Benefit in Chronic Heart Failure in CIBIS II Trial Philippe Lechat, MD, PhD; Jean-Sébastien Hulot, MD; Sylvie Escolano, MD, PhD; Alain Mallet,
More informationBiomarkers in the Age of Sacubitril/Valsa rten: Has the PARADIGM Changed
Biomarkers in the Age of Sacubitril/Valsa rten: Has the PARADIGM Changed Alan S. Maisel MD FACC Professor of Medicine, University of California, San Diego, Director, CCU and Heart Failure Program San Diego
More informationPasteur course MODELING OF INFECTIOUS DISEASES
Pasteur course MODELING OF INFECTIOUS DISEASES PROGRAM 2017-2018 Modeling of Infectious Diseases 2017-2018 CO-DIRECTORS OF THE COURSE Pierre -Yves BOËLLE Université Pierre et Marie Curie Hôpital Saint
More informationAccepted Manuscript. Letter to the Editor. Reply to: From the CUPIC study: Great times are not coming (?)
Accepted Manuscript Letter to the Editor Reply to: From the CUPIC study: Great times are not coming (?) Christophe Hezode, Helene Fontaine, Yoann Barthe, Fabrice Carrat, Jean-Pierre Bronowicki PII: S0-()00-
More informationDr. Khairy Abdel Dayem. Professor of Cardiology Ain-Shams University
Dr. Khairy Abdel Dayem Professor of Cardiology Ain-Shams University RALES Randomized Aldactone Evaluation Study 1. NEJM 1999 2. Bertram Pitt 3. 1660 Class III and IV HF patients 4. EF 35% 5. 841 placebo
More informationHEART FAILURE PATIENT MANAGEMENT. To The Power of 2!
HEART FAILURE PATIENT MANAGEMENT To The Power of 2! Put The Power of 2 To Work For You! THE PRESAGE ST2 ASSAY is a simple blood test that aids physicians in risk assessment of heart failure patients. Elevated
More informationA Multicenter Randomized Trial of Immediate Versus Delayed Invasive Strategy in Patients with Non-ST Elevation ACS
Angioplasty to Blunt the rise Of troponin in Acute coronary syndromes Randomized for an immediate or Delayed intervention A Multicenter Randomized Trial of Immediate Versus Delayed Invasive Strategy in
More informationSoFOG and the French Connection. Hervé CURÉ, MD, PhD President of the French Society of Geriatric Oncology
SoFOG and the French Connection Hervé CURÉ, MD, PhD President of the French Society of Geriatric Oncology 11 th Meeting of the ISGO Paris-France 11 Meeting of the ISGO, Paris-France November 4-5, 2011
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Le Gouill S, Thieblemont C, Oberic L, et al. Rituximab after
More informationDrugs acting on the reninangiotensin-aldosterone
Drugs acting on the reninangiotensin-aldosterone system John McMurray Eugene Braunwald Scholar in Cardiovascular Diseases, Brigham and Women s Hospital, Boston & Visiting Professor, Harvard Medical School
More informationUpdate on pharmacological treatment of heart failure. Aldo Pietro Maggioni, MD, FESC ANMCO Research Center Firenze, Italy
Update on pharmacological treatment of heart failure Aldo Pietro Maggioni, MD, FESC ANMCO Research Center Firenze, Italy Presenter Disclosures Dr. Maggioni : Serving in Committees of studies sponsored
More informationheart failure John McMurray University of Glasgow.
A to Z of RAAS blockade in heart failure John McMurray BHF Cardiovascular Research Centre University of Glasgow. RAAS inhibition in CHF ACE inhibition in patients with low LVEF CHF CONSENSUS Enalapril
More informationSECONDARY OBJECTIVES:
Study No.: 112 419 Title: Retrospective study using the NADIS database of the reasons for discontinuing the Abacavir-Lamivudine combination in HIV-infected patients treated by an antiretroviral regimen
More informationCardiotoxicity from Chemotherapy : From Early Predictors to Therapeutics
Cardiotoxicity from Chemotherapy : From Early Predictors to Therapeutics Richard Sheppard MD FRCPC Director of Heart Failure Research Heart Function Clinic Jewish General hospital Objectives 1. Discuss
More informationTechniques innovantes pour un ttt minimal invasif : le cas de la valve mitrale
Techniques innovantes pour un ttt minimal invasif : le cas de la valve mitrale Lyon Cardiothoracic and Vascular Surgery Department Hôpital Louis Pradel LYON France Affiliation/Financial Relationship List
More informationHeart Failure. GP Update Refresher 18 th January 2018
GP Update Refresher 18 th January 2018 Heart Failure Dr. Alexander Lyon Senior Lecturer and Consultant Cardiologist Clinical Lead in Cardio-Oncology Royal Brompton Hospital, London UK President of British
More informationStatistical Table 13: Prevalence of HIV infection (%) among injecting drug users under age 25, in the EU (sample sizes between brackets)
Statistical Table 3: Prevalence of HIV infection (%) among injecting drug users under, in the EU (sample sizes between brackets) HIV IDUs under Belgium, French Community 99 992 993 994 995 996 997 998
More informationCT Academy of Family Physicians Scientific Symposium October 2012 Amit Pursnani, MD
CT Academy of Family Physicians Scientific Symposium October 2012 Amit Pursnani, MD Clinical syndrome resulting from a structural or functional cardiac disorder that impairs the ability of the heart to
More informationProfessor Maurice Tubiana
Professor Maurice Tubiana The French way of life Dr. Odile Schweisguth Pediatric Radiation Oncology Daniele Sarrazin Pediatric Radiation Oncology Stanford Visitors from France A Massiot 1958 Courbevoie
More informationAntialdosterone treatment in heart failure
Update on the Treatment of Chronic Heart Failure 2012 Antialdosterone treatment in heart failure 전남의대윤현주 Chronic Heart Failure Prognosis of Heart failure Cecil, Text book of Internal Medicine, 22 th edition
More informationHôpital Lariboisière in Paris. I am really grateful to the European Society of Cardiology for
Giuseppe Vergaro, MD Division of Cardiovascular Medicine Fondazione Toscana Gabriele Monasterio Via Moruzzi, 1 56127 - Pisa To the ESC Council Members European Society of Cardiology 2035, Route des Colles
More informationHépatite auto-immune. aigue sévère
9 eme journée des Centres de Reference et de Compétence des Maladies Inflammatoires des Voies Biliaires et des Hépatites Auto-Immune (MIVB-H) llaborat ions des équipes impliquées dans l' ex plora char
More informationTitle: Usefulness of Kaposi sarcoma-associated herpesvirus (KSHV)-DNA viral. load in whole blood for the diagnosis and monitoring of KSHV-associated
JCM Accepted Manuscript Posted Online 11 April 2018 J. Clin. Microbiol. doi:10.1128/jcm.00569-18 Copyright 2018 American Society for Microbiology. All Rights Reserved. 1 2 3 Title: Usefulness of Kaposi
More informationAtrial Fibrillaiton and Heart Failure: Anticoagulation therapy in all cases?
Atrial Fibrillaiton and Heart Failure: Anticoagulation therapy in all cases? Nicolas Lellouche Fédération de Cardiologie Hôpital Henri Mondor Créteil Disclosure Statement of Financial Interest I currently
More informationHeart Failure Update. Michael Fu. Professor, Överläkare
Heart Failure Update Michael Fu Professor, Överläkare Update in Diagnosis Update in Pharmacological Treatment Update in Device Therapy Heart Failure in the Elderly Put Guidelines into Clinical Practice
More informationBrentuximab vedotin in refractory or relapsed Peripheral T-cell Lymphomas: The French named patient program experience in 56 patients
Published Ahead of Print on December 24, 2015, as doi:10.3324/haematol.2015.135400. Copyright 2015 Ferrata Storti Foundation. Brentuximab vedotin in refractory or relapsed Peripheral T-cell Lymphomas:
More informationOCTOBER 2015 FRENCH NATIONAL CANCER INSTITUTE SCIENTIFIC REPORT
OCTOBER 2015 FRENCH NATIONAL CANCER INSTITUTE SCIENTIFIC REPORT / 2014-2015 FRENCH NATIONAL CANCER INSTITUTE SCIENTIFIC REPORT / 2014-2015 The French National Cancer Institute is the health and science
More informationHypersensitivity Reactions to Contrast Media : - New concepts - Practical implications - Comparison of guidelines
Hypersensitivity Reactions to Contrast Media : - New concepts - Practical implications - Comparison of guidelines Olivier Clément, MD, PhD Hôpital Européen Georges Pompidou Paris, France Conflicts of Interest
More information