Antipsychotics. BMF 84 - Antipsychotics

Transcription

1 Antipsychotics BMF 84 - Antipsychotics Antipsychotic medications (neuroleptics) are used for the treatment of psychosis, mainly schizophrenia and manic depression (bipolar disorder). They reduce symptoms such as hallucinations, delusions, and paranoia, and can also be used to help severe anxiety or depression. Antipsychotic medications have been available for the treatment of psychosis for over half a century. The first being chlorpromazine (Thorazine), introduced in the early 1950 s. The list now extends to over 20 different compounds. Antipsychotics act by blocking dopamine receptors in the brain and interfering with dopaminergic transmission. Side effects include movement disorders similar to Parkinson s disease, such as shaking/tremor, involuntary body movements and inner restlessness. These are referred to as extrapyramidal symptoms, and can be controlled with anticholinergic drugs such as orphenadrine and procyclidine. Other side effects include lethargy, weight gain and sexual dysfunction. Longer term there is increased risk of developing type 2 diabetes, high blood pressure, heart problems and osteoporosis. Antipsychotics are may be classified as typical or atypical, or first and second generation respectively. Typical antipsychotics include; Chlorpromazine, Haloperidol, Pimozide, Trifluoperazine, and Sulpiride. Atypical include; Amisulpride, Aripiprazole, Clozapine, Olanzapine, Quetiapine and Risperidone. Atypical antipsychotics, are useful in patients that do not respond to treatment with typical antipsychotics. They cause less extrapyramidal side effects and have a greater efficacy to treat negative symptoms. Atypical antipsychotics also block dopamine, but to a lesser degree than the older drugs. They also work on serotonin. Some antipsychotics are available in depot form, i.e. Haloperidol decanoate, Flupenthixol decanoate, Fluphenazine decanoate, Pipothiazine palmitate and Zuclopenthixol decanoate. These are injected into muscle every 2 to 4 weeks and release slowly over time. This prevents patients forgetting to take their medication. sales@chiron.no Tel.: Fax.: BMF 84 p.1/6, 11_16

2 Chiron offer a range of antipsychotic reference materials and associated internal standards; Catalogue No. Description Cas No. Concentration Solvent Volume Aripiprazole (Abilify) AN Aripiprazole µg/ml acetonitrile 1 ml K-AN Aripiprazole µg/ml acetonitrile 1 ml MG Aripiprazole neat neat 10 mg MG Aripiprazole neat neat 25 mg AN Aripiprazole-d8 (butyl-d8) µg/ml acetonitrile 1 ml K-ME Amisulpride (Solian) Dehydroaripiprazole hydrochloride (Aripiprazole Impurity E) µg base/ml methanol 1 ml MG (+/-)-Amisulpride neat neat 10 mg MG (+/-)-Amisulpride neat neat 50 mg MG (+/-)-Amisulpride neat neat 100 mg Chlorpromazine (Largactil) K-ME Chlorpromazine hydrochloride µg base/ml methanol 1 ml MG Chlorpromazine hydrochloride neat neat 50 mg MG Chlorpromazine hydrochloride neat neat 100 mg ME Clozapine (Clozaril) Chlorpromazine-d6 oxalate (N,N-dimethyl-d6) µg/ml methanol 1 ml ME Clozapine µg/ml methanol 1 ml K-ME Clozapine µg/ml methanol 1 ml MG Clozapine neat neat 10 mg MG Clozapine neat neat 25 mg MG Clozapine neat neat 100 mg ME K-ME MG K-ME Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Norclozapine (N-Desmethylclozapine) µg/ml methanol 1 ml µg/ml methanol 1 ml neat neat 10 mg µg/ml methanol 1 ml ME Clozapine N-oxide µg/ml methanol 1 ml K-ME Clozapine N-oxide µg/ml methanol 1 ml Droperidol MG Droperidol neat neat 10 mg Flupentixol K-ME MG Flupentixol dihydrochloride (cis+trans) Flupentixol dihydrochloride (cis+trans) µg base/ml methanol 1 ml neat neat 10 mg sales@chiron.no Tel.: Fax.: BMF 84 p.2/6, 11_16

3 Catalogue No. Description Cas No. Concentration Solvent Volume K-ME MG Fluphenazine cis-(z)-flupentixol dihydrochloride cis-(z)-flupentixol dihydrochloride µg base/ml methanol 1 ml neat neat 10 mg K-ME Fluphenazine dihydrochloride µg base/ml methanol 1 ml MG Fluphenazine dihydrochloride neat neat 10 mg Fluspirilene MG Fluspirilene neat neat 10 mg Haloperidol (Haldol) K-ME Haloperidol µg/ml methanol 1 ml MG Haloperidol neat neat 50 mg ME Haloperidol-d4 (4-chlorophenyl-d4) µg/ml methanol 1 ml Olanzapine (Zyprexa) K-ME Levomepromazine maleate µg base/ml methanol 1 ml MG Levomepromazine maleate neat neat 10 mg MG Levomepromazine maleate neat neat 50 mg Olanzapine (Zyprexa) AN Olanzapine µg/ml acetonitrile 1 ml K-AN Olanzapine µg/ml acetonitrile 1 ml MG Olanzapine neat neat 10 mg MG Olanzapine neat neat 25 mg MG Olanzapine neat neat 100 mg MG Olanzapine neat neat 250 mg G Olanzapine neat neat 1 g AN Olanzapine-d3 (N-methyl-d3) µg/ml acetonitrile 1 ml ME Olanzapine 10-N-β-D-glucuronide µg/ml methanol 1 ml K-AN Perphenazine N-Demethylolanzapine (4 -Desmethylolanzapine, Olanzapine Impurity A) µg/ml acetonitrile 1 ml MG Perphenazine neat neat 10 mg MG Prochloroperazine Perphenazine-d4 (phenothiazine-1,3,7,9-d4) neat neat 10 mg MG Prochloroperazine maleate neat neat 10 mg Promazine K-ME Promazine hydrochloride µg base/ml methanol 1 ml MG Promazine hydrochloride neat neat 10 mg sales@chiron.no Tel.: Fax.: BMF 84 p.3/6, 11_16

4 Catalogue No. Description Cas No. Concentration Solvent Volume K-ME MG Quetiapine 2-(1-Hydroxypropyl)promazine (10H-Phenothiazine-2-methanol) 2-(1-Hydroxypropyl)promazine (10H-Phenothiazine-2-methanol) µg/ml methanol 1 ml neat neat 10 mg K-ME Quetiapine hemifumarate µg base/ml methanol 1 ml MG Quetiapine hemifumarate neat neat 10 mg Risperidone K-ME Risperidone µg/ml methanol 1 ml MG Risperidone neat neat 10 mg MG Risperidone neat neat 25 mg K-ME MG MG Thioridazine (+/-)-9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) 9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) 9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) µg/ml methanol 1 ml neat neat 10 mg neat neat 25 mg K-ME Thioridazine hydrochloride µg base/ml methanol 1 ml Trifluoperazine K-ME Trifluoperazine dihydrochloride µg base/ml methanol 1 ml MG Trifluoperazine dihydrochloride neat neat 10 mg Triflupromazine K-ME MG Trimipramine Triflupromazine hydrochloride (Trifluopromazine HCl) Triflupromazine hydrochloride (Trifluopromazine HCl) µg base/ml methanol 1 ml neat neat 10 mg K-ME Trimipramine maleate µg/ml methanol 1 ml MG Trimipramine maleate neat neat 10 mg ME MG Zuclopenthixol Trimipramine-d3 maleate (N-methyl-d3) Trimipramine-d3 maleate (N-methyl-d3) µg/ml methanol 1 ml neat neat 10 mg MG Zuclopenthixol (cis+trans) neat neat 10 mg MG Zuclopenthixol acetate (cis+trans) neat neat 10 mg MG cis-(z)-zuclopenthixol succinate (free base) neat neat 1 mg MG cis-(z)-zuclopenthixol-d4 succinate (N-hydroxyethyl-d4) (as trans-isomer) neat neat 1 mg sales@chiron.no Tel.: Fax.: BMF 84 p.4/6, 11_16

5 Catalogue No. Description Cas No. Concentration Component part Antipsychotic & Antidepressant Mix 7 Compounds at 25 μmol/l (0.025 μmol/ml) (freebase) Haloperidol [ ] 25 µmol/l Olanzapine [ ] 25µmol/L N-Desmethylolanzapine [ ] 25 µmol/l Risperidone [ ] 25 µmol/l Hydroxyrisperidone [ ] 25 µmol/l Mirtazapine [ ] 25 µmol/l Desmethylmirtazapine hydrochloride [ ] 25 µmol/l S uM-ME S uM-MEx5 1 x 1 ml ampoule 5 x 1 ml ampoules! Chiron AS is an authorised distributor of ACQ Science. Please contact us for information on ACQ Science antipsychotic (Neuroleptic) accuracy controls in serum. sales@chiron.no Tel.: Fax.: BMF 84 p.5/6, 11_16

6 For ordering and information about prices and delivery in your country, please contact your local distributor: Tel.: Fax.: BMF 84 p.6/6, 11_16