Laser CO2: una terapia ambulatoriale innovativa nel trattamento delle disfunzioni sessuali femminili
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1 Obstetrics and Gynaecology Unit Functional Unit of Urogynaecology Vita-Salute San Raffaele University and San Raffaele Hospital Milan Italy Laser CO2: una terapia ambulatoriale innovativa nel trattamento delle disfunzioni sessuali femminili Stefano Salvatore
2 Vaginal changes after menopause Senile changes in the vagina involve: Reduced vaginal blood flow Vaginal walls become thinner, less elastic, with loss of rugation Vaginal surface becomes friable with petechiae, ulcerations, and bleeding often occurring after minimal trauma. Shortening and narrowing of the vaginal canal Loss of glycogen content Loss of Lactobacilli easily replaced by pathogenic bacteria Increase of vaginal ph from to Changes in the quantity and quality of vaginal secretions Obstetrics and Gynaecology Unit Vita-Salute San Raffaele University and San Raffaele Hospital Milan, Italy
3 VVA & LUTS Urinary frequency Urgency Urge incontinence Dysuria Recurrent UTIs Obstetrics and Gynaecology Unit Vita-Salute San Raffaele University and San Raffaele Hospital Milan, Italy
4 VVA- EPIDEMIOLOGY Background To The Health Issue During , the average life expectancy of a woman in Australia was 50.8 years, ie., The end of their childbearing years Now life expectancy is 84.3 years. The average age for menopause is 51 years old. Women now have 30+ years to live after menopause Data from: Australian Bureau of Statistics
5 Managing a woman with GSM Treatment options: AJOG, 2016 Moisturizers and lubricants Estrogen therapy Selective estrogen receptor modulator (SERM) Laser therapies Synthetic steroid (tibolone) Oxytocin gel Intravaginal dehydroepiandrosterone Homeopathic remedies (black cohosh, dong quai, phytomedicines, nettle, comfrey root, motherwort, soy foods, chaste tree extract, etc.) Lifestyle modifications (increased sexual activity, stress reduction therapy and psychological counseling, cessation of smoking, etc.) Obstetrics and Gynaecology Unit Vita-Salute San Raffaele University and San Raffaele Hospital Milan, Italy
6 An almost untreated condition Postmenopausal women with vaginal atrophy worldwide 1 Key trends 75% 25% 294 million women 294 million women worldwide with symptoms of VA 221 million women untreated worldwide Treated Untreated Average duration of treatment: 43% > 1 year 2 1. The World Bank 2. Market Research: Market Landscape & Pricing; Hall & Partners Healthcare, 2008 Obstetrics and Gynaecology Unit Vita-Salute San Raffaele University and San Raffaele Hospital Milan, Italy
7 IRCCS Ospedale San Raffaele Milano Università Vita-Salute San Raffaele - Italy The VIVA (Vaginal Health: Insights, Views & Attitudes) - online survey 80% considered it to negatively affect their lives 75% reported negative consequences on sex life 68% reported that it makes them feel less sexual 36% reported that it makes them feel old 33% reported negative consequences on marriage/ relationship 26% reported a negative effect on self-esteem 25% reported that it lowers QOL 1. Nappi RE, Kokot-Kierepa M. Vaginal Health: Insights, Views & Attitudes (VIVA)Vresults from an international survey. Climacteric 2012; 15: Simon JA, Kokot-Kierepa M, Goldstein J, Nappi RE. Vaginal health in the United States: results from the Vaginal Health: Insights, Views & Attitudes survey [published online ahead of print April 15, 2013]. Menopause doi: /GME.0b013e d.
8 IRCCS Ospedale San Raffaele Milano Università Vita-Salute San Raffaele - Italy Vulvo-Vaginal Atrophy - Epidemiology Parish SJ, Nappi RE et al International Journal of Women s Health 2013:
9 Laser basics (2/5) Wavelength: expressed in nanometer (nm) Wavelengths of medical lasers UV Visible 10600nm (IR) 9 16/04/2018
10 Laser basics (3/5) Reflection Absorption: light is transformed in heat => Selective Photothermolysis Scatter Target Absorption Transmission 10 16/04/2018
11 FRACTIONAL CO2 LASER Spacing 1000 µm 11 16/04/2018
12 MICROABLATIVE FRACTIONAL CO2 LASER EP 200 μm CT 200 μm CT Postmenopausal vaginal mucosa Postmenopausal vaginal mucosa 1 month after fractional CO 2 laser treatment
13 Treatment Applicators 360 probe Standard 90 probe Narrow 16mm 90 probe
14 QUALITY OF LIFE Climacteric Feb;17(1):3-9. Impact of vulvovaginal atrophy on sexual health and quality of life at postmenopause.
15 WHAT IS THE EVIDENCE? Efficacy? Vulvovaginal Atrophy (VVA) Sexual Dysfunction Lower Urinary Tract Symptoms (LUTS)
16 FRACTIONAL CO2 LASER Vaginal dryness Dyspareunia Itching Burning Efficacy? VVA Visual analogue scale (VAS) 0 Absence of symptoms 10 Worst possible
17 Efficacy? VVA Observational studies 1-month after 3 laser sessions (1 session/month) n= 255
18 Female Sexual Function Index (FSFI) Lubrication Orgasm Domains Arousal Efficacy? VVA Sexual Dysfunction Sexual satisfaction Desire Pain Dyspareunia (VAS 0-10) Overall sexual satisfaction (VAS 0-10)
19 2017;5: Efficacy? VVA Sexual Dysfunction Observational studies 1-month after 3 laser sessions (1 session/month) n= 273
20 Dyspareunia 2017;5: Efficacy? VVA Sexual Dysfunction Overall satisfaction
21 HOW MANY LASER SESSIONS? Resumption of sexual intercourse? Improvement of symptoms? Complete resolution of symptoms? Efficacy?
22 HOW MANY LASER SESSIONS? Baseline After 1 session After 3 sessions Efficacy? Resumption of sexual intercourse? 1 SESSION?
23 HOW MANY LASER SESSIONS? ,1 8,3 Dryness 5,7 Dyspareunia Efficacy? ,5 4,5 3,4 3,3 2,7 Improvement of symptoms? 1 0 Baseline After 1 session After 2 sessions After 3 sessions
24 HOW MANY LASER SESSIONS? 3-5 SESSIONS? Complete resolution of symptoms? (VAS zero) Dryness Dyspareunia Baseline After 3 sessions After 4 sessions After 5 sessions Baseline After 3 sessions After 4 sessions After 5 sessions
25 HOW MANY LASER SESSIONS? Normal Sexual Function 4 41 Baseline After 3 sessions 69 After 4 sessions 84 After 5 sessions Efficacy? Normal Sexual Function? (Total FSFI> 26.55) 3-5 SESSIONS?
26 FRACTIONAL CO2 LASER Postmenopausal women Efficacy? VVA Sexual dysfunction LUTS (UTIs) Decrease in Lactobacilli Increase ph Loss of vaginal defense mechanisms Predisposition to infections High incidence of UTIs (8%) and recurrence
27 2016 Efficacy? VVA VVA Sexual dysfunction LUTS (UTIs) Observational study 1-month after 3 laser sessions (1 session/month) n=53
28 A double-blind randomised controlled trial of microablative fractional CO 2 laser vs sham therapy on patients with vaginal dryness linked sexual function limitations: an interim analysis S. Girardelli, E. Pitsouni, E. Marotta, M. Parma, M. Candiani, S. Athanasiou, S. Salvatore
29 Vaginal Dryness Burning 5 9 4, , active sham 2,5 2 1,5 active sham ,5 0 baseline t1 0 baseline T4 Vaginal Dryness Baseline T4 p - value Active < 0.05 Sham > 0.05
30 Changes in dyspareunia 9 VAS dyspareunia before and after treatment dyspareunia sham dyspareunia active Dispareunia before After p - value Sham > 0.05 active < 0.05
31 Changes in FSFI 25 FSFI changes before and after treatment FSFI active FSFI sham 5 0 before after
32 FRACTIONAL CO2 LASER Safety? No serious adverse events Pain at the probe insertion Mild irritation of the vulva and introitus Mild to moderate lower pelvic pain Minor bleeding Vaginal discharge Recommendation to avoid intercourse for 3 days
33 CO 2 -laser improves all GSM symptoms Persistence of positive effect on long-term follow-up 3-5 laser sessions No serious adverse events
34 Thank you for your attention! Obstetrics and Gynaecology Unit Vita-Salute San Raffaele University and San Raffaele Hospital Milan, Italy
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