You submitted this quiz on Sun 19 May :32 PM IST (UTC +0530). You got a score of out of

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1 Feedback Ex6 You submitted this quiz on Sun 19 May :32 PM IST (UTC +0530). You got a score of out of Question 1 What is common to Parkinson, Alzheimer and Autism? Electrical (deep brain) stimulation of the basal ganglia improves the patients' quality of life Mutations in the same gene are responsible for all the three diseases The electrical activity of the brain is different comparing with a non sick brain. All the three diseases emerge in adults Total / Question 2 Mammals are different from other animals by having the neocortex. Mark the correct sentences: Only in the neocortex one finds pyramidal cells In different brain regions, the neocortex is specialized in different computational tasks The neocortex typically consists of 6 layers The neocortex in all regions shows clear structural partition into columns 1/6

2 Total / Question 3 In a cubic mm of a mammalian cortex There are ~ 300,000 neurons and ~ synapses There are ~ 3,000 neurons and ~ synapses 10 8 There are ~ 30,000 neurons and ~ synapses There are ~ 3,000 neurons and ~ synapses Total / Question 4 Layer 5 pyramidal cell in a mammalian neocortex: Receives input from different types of cells Its dendritic tree resides only at layer 5 of the neocortex Receives input from different layers in the cortex May receive input also from neurons outside the cortex, sending their axon to the cortex Receive only excitatory input from layer 4 spiny stellate cells Total / 2/6

3 Question 5 In the mouse barrel cortex: The sensory information that reaches each column remains sensory throughout the whole brain of the mouse There is a clear anatomical separation among the columns Each column receives primary input from a particular whisker The computations performed within each column are isolated from those of other columns Total / Question 6 Input (axon) from the thalamus to the mouse barrel cortex: There is no direct connection between the thalamus (subcortical area) and the cortex Impinges only onto layer 4 of the cortex Impinges mainly onto layer 4 of the cortex Impinges mainly with layer 5 Total / Question 7 3/6

4 Mark the correct sentences: The orientation of the column is defined by its physical orientation with respect to the skull Cells in cat V1 are plastic experience can change the orientation selectivity of the column In cat V1 there are functional columns most of the cells in the column respond to the same orientation of the visual input As in the mouse whisker system, cat V1 also consists of anatomically-identified columns Total / Question 8 Different types of cells in the cortical column are different from each other in: Their electrical characteristics Different cells have significantly different spike shape. Their anatomy By their target output and by their synaptic effect (e.g., inhibitory/excitatory) Different cell types have a different DNA sequence Total / Question 9 4/6

5 Models of a cells in the blue brain project (BBP) include: The cell morphology the size and the location of its dendrites and axon Simulations also include the activity of various genes and proteins The cell electrical properties a set of equations that replicates the firing properties of a similar cell in the cortex The synaptic properties impinging on other neurons in the network Each cell is represented as a single compartment cell ( point neuron ) Total / Question 10 Simulation of a particular disease in the BBP means That the dynamic properties of the simulated network replicate closely to that of the corresponding disease That we can repair the disease via interaction between the computer simulation and the sick brain That the simulation enables the identification of possible (synaptic, excitable or anatomical) changes underlying the disease That the spiking activity of different electrical-neuron types is replicated closely in the simulations That the genes expressed in that disease are simulated in details Total / 5/6

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