APOKYN (apomorphine hydrochloride)
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- Diana Hardy
- 5 years ago
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1 APOKYN (apomorphine hydrochloride) Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Medical Coverage Guideline must be read in its entirety to determine coverage eligibility, if any. This Medical Coverage Guideline provides information related to coverage determinations only and does not imply that a service or treatment is clinically appropriate or inappropriate. The provider and the member are responsible for all decisions regarding the appropriateness of care. Providers should provide BCBSAZ complete medical rationale when requesting any exceptions to these guidelines. The section identified as Description defines or describes a service, procedure, medical device or drug and is in no way intended as a statement of medical necessity and/or coverage. The section identified as Criteria defines criteria to determine whether a service, procedure, medical device or drug is considered medically necessary or experimental or investigational. State or federal mandates, e.g., FEP program, may dictate that any drug, device or biological product approved by the U.S. Food and Drug Administration (FDA) may not be considered experimental or investigational and thus the drug, device or biological product may be assessed only on the basis of medical necessity. Medical Coverage Guidelines are subject to change as new information becomes available. For purposes of this Medical Coverage Guideline, the terms "experimental" and "investigational" are considered to be interchangeable. BLUE CROSS, BLUE SHIELD and the Cross and Shield Symbols are registered service marks of the Blue Cross and Blue Shield Association, an association of independent Blue Cross and Blue Shield Plans. All other trademarks and service marks contained in this guideline are the property of their respective owners, which are not affiliated with BCBSAZ. Description: Apokyn is a non-ergoline dopamine agonist. The precise mechanism of action as a treatment for Parkinson s disease is unknown, although it is believed to be due to stimulation of post-synaptic dopamine D2-type receptors within the caudate-putamen in the brain. O docx Page 1 of 6
2 Description: (cont.) Oral medications containing levodopa are the most commonly prescribed treatment for Parkinson s disease (PD). These medications usually work quite well when first given. After some time individuals may start experiencing decreased on time and may have what are known as off episodes. Being on is when the oral levodopa medication is working well, PD symptoms are at a minimum and the individual is moving and able to go about daily activities. Being off is when the oral levodopa medication hasn t taken effect or its effects have worn off and PD symptoms re-emerge and are at or near their worst. Off episodes may be characterized by muscle stiffness, slow movements, or difficulty starting movements. Off episodes are common in PD and can happen at any time. Definitions: Adult: Age 18 years and older Criteria: See Resources section for FDA-approved dosage. Apokyn for the acute, intermittent treatment of adults with advanced Parkinson s disease is considered medically necessary with documentation of ALL of the following: 1. Individual is experiencing hypomobility or off episodes ( end-of-dose wearing off and unpredictable on/off episodes) 2. Individual is receiving maximal therapy of at least ONE of the following medications, to include, but not limited to: Benztropine Carbidopa/levodopa Pramipexole Ropinirole 3. Treatment with trimethobenzamide, starting 3 days prior to the first dose of Apokyn, and for as long as needed to control nausea and vomiting (generally no longer than two months) 4. Absence of ALL of the following contraindications: Concomitant use with 5-HT3 antagonists, including antiemetics (e.g., ondansetron, granisetron, dolasetron, palonosetron) and alosetron Hypersensitivity reaction to Apokyn, its excipients or sodium metabisulfite O docx Page 2 of 6
3 Criteria: (cont.) Apokyn for all other indications not previously listed or if above criteria not met is considered experimental or investigational based upon: 1. Insufficient scientific evidence to permit conclusions concerning the effect on health outcomes, and 2. Insufficient evidence to support improvement of the net health outcome, and 3. Insufficient evidence to support improvement of the net health outcome as much as, or more than, established alternatives, and 4. Insufficient evidence to support improvement outside the investigational setting. These indications include, but are not limited to: Treatment with dosing or frequency outside the FDA-approved dosing and frequency O docx Page 3 of 6
4 Resources: Literature reviewed 11/14/17. We do not include marketing materials, poster boards and nonpublished literature in our review. Apokyn Package Insert: - FDA-approved indication and dosage: Indication For the acute, intermittent treatment of hypomobility, off episodes ( end-of-dose wearing off and unpredictable on/off episodes) in individuals with advanced Parkinson s disease It is unknown whether this drug is excreted in human milk. A decision should be made as to whether to discontinue nursing or to discontinue the drug Safety and effectiveness in pediatric patients have not been established Recommended Dose Apokyn is indicated for subcutaneous administration only and only by a multiple-dose Apokyn Pen with supplied cartridges. (Multi-dose glass cartridges, 30 mg/3 ml (10 mg/ml) for use with a multiple-dose pen injector) (Apokyn Pen). The starting dose is 0.2 ml (2mg); give the first dose under medical supervision; titrate the dose to effect and tolerance; the maximum recommended dose is 0.6 ml. Treatment with a concomitant antiemetic, e.g., trimethobenzamide, is recommended, starting 3 days prior to the first dose of Apokyn. Treatment with trimethobenzamide should only be continued as long as necessary to control nausea and vomiting, and generally no longer than two months. If a single dose is ineffective for a particular off period, a second dose should not be given for that off episode. Do not administer a repeat dose sooner than 2 hours after the last dose. For mild and moderate renal impairment: reduce test dose, and reduce starting dose to 0.1 ml (1 mg) O docx Page 4 of 6
5 Non-Discrimination Statement: Blue Cross Blue Shield of Arizona (BCBSAZ) complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability or sex. BCBSAZ provides appropriate free aids and services, such as qualified interpreters and written information in other formats, to people with disabilities to communicate effectively with us. BCBSAZ also provides free language services to people whose primary language is not English, such as qualified interpreters and information written in other languages. If you need these services, call (602) for Spanish and (877) for all other languages and other aids and services. If you believe that BCBSAZ has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability or sex, you can file a grievance with: BCBSAZ s Civil Rights Coordinator, Attn: Civil Rights Coordinator, Blue Cross Blue Shield of Arizona, P.O. Box 13466, Phoenix, AZ , (602) , TTY/TDD (602) , crc@azblue.com. You can file a grievance in person or by mail or . If you need help filing a grievance BCBSAZ s Civil Rights Coordinator is available to help you. You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at or by mail or phone at: U.S. Department of Health and Human Services, 200 Independence Avenue SW., Room 509F, HHH Building, Washington, DC 20201, , (TDD). Complaint forms are available at Multi-Language Interpreter Services: O docx Page 5 of 6
6 Multi-Language Interpreter Services: (cont.) O docx Page 6 of 6
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