NOTE: PODCAST/MP3 PROGRAM 1

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1 PODCAST/MP3 PROGRAM 1 I N S T R U C T I O N S This program consists of a podcast/mp3 audio file and a printable PDF of the post-test that can be submitted for credit and/or used to assist learning. You may play the audio online or download the file to an MP3 audio player, such as an ipod. You will also need Adobe Acrobat Reader to view and print the PDF post-test and evaluation. Credit is awarded to participants who complete the evaluation and answer the post-test questions correctly. There is no fee to participate and receive credit. 1. Download the podcast or MP3 audio file to your player. 2. Listen to the presentation before filling out the post-test and evaluation. It should take approximately 15 minutes to listen to the audio file and complete the post-test and evaluation. 3. To receive CME/CE credit, use the link to the online test or print the post-test and evaluation pages found at the end of this PDF file. 4. Follow the provided instructions to complete and submit the CME/CE post-test and evaluation. NOTE: The post-test and evaluation for this program is available online at Please complete the test and evaluation online to immediately receive a statement of CME/CE credit.

2 Release Date: August 27, 2007 Credit Expiration Date: August 31, 2008 F A C U L T Y Kenneth D. Aldape, MD Associate Professor Pathology/Neuropathology University of Texas MD Anderson Cancer Center Houston, TX Terri S. Armstrong, DSN, APRN Neuro-Oncology Nurse Practitioner University of Texas MD Anderson Cancer Center Houston, TX Arnab Chakravarti, MD Director, Laboratory of Molecular & Cellular Radiation Neuro-Oncology Associate Professor of Radiation Oncology Massachusetts General Hospital Harvard Medical School Boston, MA Mark R. Gilbert, MD Professor & Deputy Chair Department of Neuro-Oncology University of Texas MD Anderson Cancer Center Houston, TX Minesh P. Mehta, MD Professor, Department of Human Oncology University of Wisconsin-Madison Madison, WI Michael A. Vogelbaum, MD, PhD Associate Director, Brain Tumor and Neuro-Oncology Center Director, Center for Translational Therapeutics Cleveland Clinic Cleveland, OH C O N F L I C T O F I N T E R E S T S T A T E M E N T S It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflict of interest is resolved by AKH prior to accreditation of the activity. Dr. Armstrong discloses research and grant funding from Schering-Plough. Dr. Gilbert discloses participation on advisory committees for Genentech and Schering-Plough and speakers bureau participation for Schering-Plough. Dr. Mehta discloses product consultation for Allos and speakers bureau participation for Schering-Plough and Tomotherapy. Dr. Vogelbaum discloses participation on advisory board committees for MGI Pharma, Neopharm, and Schering-Plough. He is also a speakers bureau participant for Schering-Plough. Drs. Aldape and Chakravarti indicate they have no actual or potential conflict of interest to this program. This educational activity may contain discussion of investigational uses of pharmaceutical agents or surgical devices. Some of these agents/devices may not have been approved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

3 T A R G E T A U D I E N C E This program, developed by experts in radiation oncology, neuro-oncology, neurosurgery, molecular biology, pathology, and neuro-oncology nursing has been designed for physicians and advance practice nurses who interact with oncology patients. L E A R N I N G O B J E C T I V E S Upon completion of this program, the participant should be able to: 1. Identify the histologic subtypes of primary gliomas and the prognosis typical of each. 2. Discuss the importance of clinical and molecular biomarkers in identifying prognostic variables. 3. Review the clinical trial evidence that led to defining combination chemoradiotherapy as the new standard of care for some malignant gliomas. A B B R E V I A T I O N S & D R U G N A M E S C I T E D 1p/19q = specific chromosomes BCNU = carmustine BCNU polymer wafer (Gliadel ) EORTC = European Organization for Research in the Treatment of Cancer MGMT = methyl-guanine methyltransferase O 6 -BG = O 6 -benzylguanine RPA = recursive partitioning analysis RTOG = Radiation Therapy Oncology Group temozolomide (Temodar ) C R E D I T S T A T E M E N T S Physicians: This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of AKH Inc. and Medical Communications Media. AKH Inc. is accredited by the ACCME to provide continuing medical education for physicians. AKH Inc. designates this educational activity for a maximum of 0.25 AMA PRA Category 1 Credit. Physicians should only claim credit commensurate with the extent of their participation in the activity. Nurses: AKH Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. AKH Inc. designates this educational activity for 0.25 contact hour (0.025 CEU). Supported through an educational grant from 2007 Medical Communications Media, Inc. All rights reserved. This publication is designed for use with an audio recording. None of the contents may be reproduced in any form without prior written permission from the publisher. The opinions expressed in the audio recording are those of the presenters and do not necessarily reflect the opinions or recommendations of their affiliated institutions, the publisher, AKH Inc., or Schering-Plough. Any medications, diagnostic procedures, or treatments discussed by the program presenters should not be used by clinicians or other healthcare professionals without first evaluating their patients conditions, considering possible contraindications or risks, reviewing any applicable manufacturer s product information, and comparing any therapeutic approach with the recommendations of other authorities.

4 Release Date: August 27, 2007 Credit Expiration Date: August 31, 2008 C M E / C E P O S T - T E S T Please complete the post-test and evaluation online at One retake is allowed. Please print and mail the PDF forms only if you do not have an internet connection. If you do not have internet access: To receive credit, please print or type the required information below, complete the following post-test and program evaluation and mail the forms in an envelope to: Medical Communications Media, 54 Friends Lane, Suite 125, Newtown, PA A CME/CE statement will be awarded for answering the post-test questions correctly and completing the evaluation. Statements of credit will be mailed within 6 weeks for mailed submissions or can be generated immediately for online submissions. Credit requested: MD/DO (AMA) I am claiming AMA PRA Category 1 Credit (maximum 0.25). Nurse (ANCC) Other (AMA) Name (last) (first) (middle) Degree/title Specialty Hospital or Practice Name Address City State Zip Phone FAX Please circle the most appropriate answer to the following questions: 1. Combination chemoradiation using temozolomide is currently considered standard treatment for which tumor grade(s)? a) Low-grade b) Grade III c) Grade IV d) Grades III & IV 2. Loss of heterozygosity on chromosomes 1p and 19q has so far been observed to be a key distinguishing prognostic factor in which type of tumor? a) glioblastoma b) anaplastic oligodendroglioma c) anaplastic astrocytoma 07 SC BRN POD1

5 Release Date: August 27, 2007 Credit Expiration Date: August 31, 2008 P R O G R A M E V A L U A T I O N Please complete this program evaluation so that we may continue to provide you with high-quality educational activities. Please indicate your answer by circling the appropriate number. Strongly Agree Strongly Disagree 1) As a result of my participation in this activity, I am better able to: Identify the histologic subtypes of primary gliomas and the prognosis typical of each Discuss the importance of clinical and molecular biomarkers in identifying prognostic variables Explain the value of developing clinical translational studies and establishing new treatment paradigms Review the clinical trial evidence that led to defining combination chemoradiotherapy as the new standard of care for some malignant gliomas ) This activity increased my awareness and understanding of the subject matter ) The information provided in this activity will be useful to me professionally ) Do you anticipate any changes in your diagnosis or management of malignant gliomas as a result of this program? Yes No Please explain: 5) Was the content clear and well organized? Yes No 6) Was the faculty up-to-date and knowledgeable? Yes No 7) Was the activity objective, scientifically balanced, and free of commercial bias? Yes No 8) The audio podcast format is an effective way to learn about this subject matter. Yes No 9) What clinical problems related to brain tumors are you or your colleagues facing about which you would like to learn more? 10) Additional comments: 07 SC BRN POD1

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