Pineal region tumors
|
|
- Ilene Atkinson
- 5 years ago
- Views:
Transcription
1 Case Series Pineal region tumors Meena Patil, Manjiri Karandikar Abstract The pineal gland is located near the center of the brain, between two hemispheres in between the two thalamic bodies. It is activated by light and controls the various bio-rhythms of the body. It also secretes melatonin a potent regulator of gonadotrophic and other endocrine hormonal activity. It is made of cells, called pineocytes and tumors arise from these cells as also from other cells in the pineal region. Pineal tumors account for 1% of all brain tumors. Tumors of pineal parenchymal lineage include germ cell tumors, embryonal pineoblastoma, the mature pineocytoma, and lesions exhibiting mixed histology or intermediate degree of differentiation. During the period January 2008 to December 2011, we encountered three cases of pineal tumors. A brief summary of these cases is given in this case report. Keywords: Papillary tumor of pineal region, pineal gland, pineoblastoma, pineocytoma Introduction Pineal region tumors are derived from cells located in and around the pineal gland. The principle cell of the pineal gland is the pineal parenchymal cell or pineocyte. This cell is a specialized neuron related to retinal rods and cones. These pineocytes are surrounded by a stroma of fibrillary astrocytes, which interact with adjoining blood vessels to form part of the blood - pial barrier. The cells of the pineal gland are unique in that they are not related to the support cells of the brain (astrocytes, etc.) or to the brain neurons, rather they develop on their own. Therefore, the true pineal cell tumors are quite different from other brain tumors. [1] Pineal region tumors make up % of intracranial tumours in adults and % of brain tumors in children. Most children are aged years at Quick Response Code: Access this article online Website: DOI: / presentation with average age at presentation being 13 years. Adults typically are older than 30 years at presentation. [1] Tumors of the pineal region have a varied histology that can generally be divided into germ cell and non-germ cell derivatives. Most tumors are a result of displaced embryonic tissue, malignant transformation of pineal parenchymal cells, or transformation of surrounding astrocytes. [1] During the period January 2008 to December 2011, three cases of pineal tumors got operated at Bharati Hospital. A brief summary of these cases is given below. Case Report 1 An 8 year female child presented with headache, vomiting, neck pain for 1 month, and diminished vision for 15 days. History of midbrain glioma operated 2 years back was reported. MRI brain showed a well-defined lobulated lesion in posterior third ventricular region beneath the splenium Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India Address for correspondence: Asst. Prof. Meena Patil, Flat no. 8, Surya Appt., Kohinoor colony, Sahakarnagar no. 2, Pune , Maharashtra, India. meenipatil@yahoo.co.in
2 101 and corpus callosum and posteriorly upto midbrain. Lesion was causing compression of distal third ventricle with obstructive hydrocephalus. Differential diagnoses of pineal germinoma and midbrain glioma were offered. Tissue was sent for frozen section. Smears from crush cytology and frozen sections showed predominantly uniform round tumour cells with central prominent nuclei and clumped chromatin. Occasional mitotic figures were noted. Tumor was excised from posterior cranial fossa and sent for histopathology. b a c d e Figure 1: H and E 100 Papillary tumor of pineal region, (a) PTPR Vimentin positive, (b) PTPR S-100 Protein positive, (c) PTPR p53 focal positive, (d) PTPR Low MIB 1 index Histopathology showed a cellular tumor comprised very primitive cells with dense, hyperchromatic and some angulated nuclei with very scanty cytoplasm. The tumor cells show perivascular arrangement. A small component of more differentiated cells forming pineocytomatous rosettes was also seen. Areas of necrosis were also noted. Histopathological diagnosis of Pineal parenchymal tumor of intermediate differentiation with mixed embryonal pineoblastoma and pineocytoma [Figure 3]. Case Report 2 A 25 year female presented with headache, nausea, vomiting for one year, watery discharge from both eyes and intermittent giddiness. Figure 2: Frozen section Toludine blue-pineal parenchymal tumor of intermediate differentiation (PPTID) Sagittal and coronal (T1 weighted magnetic resonance) T1W MR images revealed well defined irregular heterogeneously enhancing lesion in the region of the pineal gland effacing the posterior aspect of the third ventricle and compressing the quadrigeminal plate, without causing hydrocephalus. MRI brain was suggestive of pineal gland tumor or germinoma. Crush cytology smears and frozen sections showed round to oval cells showing monomorphism and absence of mitotic activity. Diagnosis of pineocytoma was offered. The tumor from posterior fossa was removed and sent for histopathology [Figure 2]. March 2015 Vol 20 Issue 1 Figure 3: H and E Pineal parenchymal tumor of intermediate differentiation (PPTID) Histopathology showed a tumor composed of small round cells with central hyperchromatic nuclei and scanty eosinophilic cytoplasm, arranged in sheets Journal of Mahatma Gandhi Institute of Medical Sciences
3 102 separated by thin fibrocollagenous stroma. At places perivascular arrangement was also seen. Few foci of necroinflammation and psammomatous calcification were noted. Histopathological diagnosis was pineal parenchymal tumor of intermediate differentiation (PPTID) [Figure 3]. After 3 years she presented with metastasis in thoracic and lumbosacral spine. Sagittal T1W MR image of thoracic spine and lumbosacral spine revealed multiple lesions of solid nature with cystic areas of varying sizes dispersed throughout the spinal cord, in the intramedullary and subdural space predominantly involving the thoracic spine [Figures 4 and 5]. Patient was managed with chemotherapy and radiotherapy. Case Report 3 A 60 year old female presented with headache and reduced vision for 2 months, urinary incontinence and giddiness for 1 month. History of pineal gland tumor excised 1 year back. MRI brain showed well demarcated mass in pineal region cm 2 with hydrocephalus and areas of hemorrhage and calcification. Ventricles were normal with a shunt in situ. Excised pineal gland tumor was sent for histopathology. perivascular pseudorosettes and distinctive papillary growth pattern. Blood vessels appeared to be covered by multiple layers of tumor cells. Histopathological diagnosis was Papillary tumor of pineal region [Figure 1a]. Immunohistochemistry (IHC) showed strong reactivity for vimentin, S 100 protein, focal positivity for p53, and low MIB 1 index. EMA, CK 8-18, and GFAP, synaptophysin were negative [Figure 1b]. Discussion Tumors of the pineal region (so called pinealomas ) include germ cell tumors, which are the most common lesions in this region, as well as tumors derived from the pineocytes or their precursors. They exhibit a spectrum of differentiation ranging from tumors consisting of primitive undifferentiated cells to those comprised of mature elements. [1] These neoplasms present as solid contrast-enhancing masses associated with manifestations of obstructive hydrocephalus owing to aqueductal compression. Disturbances of ocular motility resulting from pressure on the mesencephalic tectum is another common symptom. [1] Pineal Parenchymal tumor of Intermediate Differentiation [2] These neoplasms occupy a rather broad middle ground between the mature and embryonal extremes. Histopathology showed cellular neoplasm characterized by eosinophilic cells with indistinct cell borders, large pleomorphic nuclei with columnar and cuboidal morphology. They were arranged in Figure 4: Sagittal and coronal T1W MR images revealed well-defined irregular heterogeneously enhancing lesion in the region of the pineal gland effacing the posterior aspect of the third ventricle and compressing the quadrigeminal plate without causing hydrocephalus Figure 5: PPTID-Sagittal T1W MR image of thoracic spine and lumbosacral spine revealed multiple lesions of solid nature with cystic areas of varying sizes dispersed throughout the spinal cord, in the intramedullary and subdural space predominantly involving the thoracic spine
4 103 Clinical behavior of these tumors is variable. One variant is characterized by a neuroendocrine histologic profile in which small tumor cells are segregated into lobules surrounded by a delicate vasculature and a second by a more sheetlike proliferation of neoplastic elements in a scant fibrillary matrix. These pineocytic neoplasms can achieve relatively dense cellularity, occasional evidence of necrosis and may exhibit mitotic activity, but fall short of frank anaplasia and conspicuous proliferative activity that typifies pineoblastomas. Many behave in a relatively low-grade fashion but cerebrospinal fluid (CSF) born metastasis has been documented as an exceptional occurrence. [2] In one of our case metastasis from previous pineal tumor occurred in thoracic and lumbosacral spine after 3 years. Search for any other primary was done but no other primary lesion was found. Papillary Tumor of Pineal Region (PTPR) [3] Papillary tumor of pineal region is thought to arise from the specialized ependyma of the subcommissural organ. This assumption is based on of histomorphological and ultrastructural features, the characteristic anatomic localization in the posterior third ventricular region, and gene expression data. The sub commisural organ is a conserved brain gland present throughout the vertebrate phylum. It is an active secretory structure of brain in a 3-5 month old fetus. However it appears regressed in 9 month old fetus. This regression continues during childhood so that by 9 years of life, it is seen as few islets of cuboidal, nonsecretory ependyma. Papillary tumor of pineal region arises exclusively in the pineal region and occurs most commonly in adults with slight preponderance in females. Headache of short duration is the common presenting system. PTPR is a rare entity described in WHO 2007 classification of brain tumors and assigned a provisional code (ICD O code of 9395/3). In 2003, Jouvet and colleagues reported six cases under the title Papillary tumor of pineal region. These tumors typically present as relatively large, circumscribed mass lesions of the pineal region. Symptoms are typically related to obstructive hydrocephalus secondary to compression of cerebral aqueduct. Progression occurs in almost 75% of patients. Incomplete resection and increase mitotic activity indicate poor prognosis. PTPR is immunoreactive for broad spectrum of cytokeratins including KL1, AE1/AE3, CAM 5.2 and cytokeratin 18. PTPRs have also been reported to express vimentin, S 100 protein, MAP 2, N CAM and transthyretin. Reactivity for GFAP has been reported in approximately 12% of tumor, typically restricted to perivascular areas of tumor. No immunolabelling for neurofilament protein has been reported. Immunohistochemistry (IHC) of our case showed strong reactivity for vimentin, S 100 protein, focal positivity for p53, and low MIB 1 index. EMA, CK 8-18, and GFAP, synaptophysin were negative. The differential diagnosis of PTPR is broad and includes all pineal region lesions with papillary architecture. These include pineal parenchymal tumors, papillary ependymoma and metastases. Unlike PTPR, pineal parenchymal tumors show strong immunoexpression of neuronal markers. Distinction of PTPR from metastatic papillary carcinoma of unknown primary, is based on very low or absent expression of CK7/CK20 and low MIB 1 labelling indices that are characteristic of PTPR. Both PTPR and choroid plexus papilloma express cytokeratins and transthyretin; however most PTPRs show MAP 2 staining and do not express Kir 7.1, which is marker of choroid plexus tumor. Papillary meningioma can be usually excluded easily due to its CK negativity. Papillary tumors of pineal region are characterized by frequent local recurrence as in our case but spinal dissemination is rare Hence it is taken as a grade II/III tumor in WHO classification. [3] Conclusion Pineal gland once thought to be a vestigeal organ is the site of occurrence of a small percentage of intracranial space occupying lesions. Advanced radiologic techniques and stereotactic surgery definitely make the tumors of pineal region more accessible and amenable to treatment. Immunohistochemistry has been helpful in subclassification of pineal region tumors. March 2015 Vol 20 Issue 1 Journal of Mahatma Gandhi Institute of Medical Sciences
5 104 References 1. Bruce JN, Wyler AR. Pineal Tumors. Available from: workup. [Last accessed on 2013 Apr 17]. 2. Rosai J. Neuromuscular system- Central Nervous System: Primary tumors: Pineal parenchymal tumors. In: Rosai and Ackerman s Surgical Pathology- Vol II. 9 th ed. India; Mosby: p Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114: How to cite this article: Patil M, Karandikar M. Pineal region tumors. J Mahatma Gandhi Inst Med Sci 2015;20: Source of Support: Nil, Conflict of Interest: None declared.
CNS TUMORS. D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria)
CNS TUMORS D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria) CNS TUMORS The annual incidence of intracranial tumors of the CNS ISmore than intraspinal tumors May be Primary or Secondary
More informationAnatomy, Histology and general pathology of the Pineal gland. Uri Shiri 1 st year, Int. medicine B
Anatomy, Histology and general pathology of the Pineal gland Uri Shiri 1 st year, Int. medicine B The Pineal gland A small, ~8mm sized Endocrine gland. The Pineal gland A small, ~8mm sized Endocrine gland.
More informationCNS pathology Third year medical students. Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3
CNS pathology Third year medical students Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3 Pilocytic astrocytoma Relatively benign ( WHO grade 1) Occurs in children and young adults Mostly: in the cerebellum
More informationSPECIAL SLIDE SEMINAR CASE 3
SPECIAL SLIDE SEMINAR CASE 3 Tihana Džombeta, MD Leo Pažanin, MD, PhD Department of Pathology, School of Medicine, University of Zagreb Department of Pathology, Clinical Hospital Centre Sestre milosrdnice
More informationAMERICAN ASSOCIATION OF NEUROPATHOLOGISTS COMPANION SOCIETY MEETING at the 106 th ANNUAL MEETING OF THE USCAP San Antonio, March 4, 2017
AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS COMPANION SOCIETY MEETING at the 106 th ANNUAL MEETING OF THE USCAP San Antonio, March 4, 2017 SYLLABUS Papillary Tumor of the Pineal Region and the Differential
More informationPathologic Analysis of CNS Surgical Specimens
2015 Kenneth M. Earle Memorial Neuropathology Review Pathologic Analysis of CNS Surgical Specimens Peter C. Burger, MD Interdisciplinary Quality Control Familiarity with entities Use of diagnostic algorithm
More informationGeneral: Brain tumors are lesions that have mass effect distorting the normal tissue and often result in increased intracranial pressure.
1 Lecture Objectives Know the histologic features of the most common tumors of the CNS. Know the differences in behavior of the different tumor types. Be aware of the treatment modalities in the various
More informationAnaplastic Pilocytic Astrocytoma: The fusion of good and bad
Anaplastic Pilocytic Astrocytoma: The fusion of good and bad Alexandrina Nikova 1, Charalampos-Chrysovalantis Chytoudis-Peroudis 2, Penelope Korkolopoulou 3 and Dimitrios Kanakis 4 Abstract 5 Pilocytic
More informationTumors of the Nervous System
Tumors of the Nervous System Peter Canoll MD. PhD. What I want to cover What are the most common types of brain tumors? Who gets them? How do they present? What do they look like? How do they behave? 1
More informationBrain Tumors. Medulloblastoma. Pilocytic astrocytoma: Ahmed Koriesh, MD. Pathological finding
NeuroPathology Page 8 Brain Tumors Pathological finding Pseudorosette Rosenthal fibers Rosettes Wet Keratin Psammoma bodies Fried egg Tumor Ependymoma, SEGA Pilocytic astrocytoma Medulloblastoma Craniopharyngioma
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationPeter Canoll MD. PhD.
Tumors of the Nervous System Peter Canoll MD. PhD. What I want to cover What are the most common types of brain tumors? Who gets them? How do they ypresent? What do they look like? How do they behave?
More informationCase Report Papillary Tumor of the Pineal Region: MR Signal Intensity Correlated to Histopathology
Case Reports in Neurological Medicine Volume 2015, Article ID 315095, 4 pages http://dx.doi.org/10.1155/2015/315095 Case Report Papillary Tumor of the Pineal Region: MR Signal Intensity Correlated to Histopathology
More informationImportance of initial aggressive treatment for pineal parenchymal tumor of intermediate differentiation: A case report and review of literature
Practical Radiation Oncology (2013) 3, e29 e34 www.practicalradonc.org Teaching Case Importance of initial aggressive treatment for pineal parenchymal tumor of intermediate differentiation: A case report
More informationPapillary Lesions of the Breast A Practical Approach to Diagnosis. (Arch Pathol Lab Med. 2016;140: ; doi: /arpa.
Papillary Lesions of the Breast A Practical Approach to Diagnosis (Arch Pathol Lab Med. 2016;140:1052 1059; doi: 10.5858/arpa.2016-0219-RA) Papillary lesions of the breast Span the spectrum of benign,
More informationNote: The cause of testicular neoplasms remains unknown
- In the 15- to 34-year-old age group, they are the most common tumors of men. - Tumors of the testis are a heterogeneous group of neoplasms that include: I. Germ cell tumors : 95%; all are malignant.
More informationSymtomatic Subependymoma Of The Lateral Ventricle: A Rare Entity A Case report and review of literature
ISPUB.COM The Internet Journal of Neurosurgery Volume 7 Number 1 Symtomatic Subependymoma Of The Lateral Ventricle: A Rare Entity A Case report and review of M Sharma, V Velho, P Ghodgaonkar, D Palande
More informationDisclosures. The Thin Red Line Between Neuropathology and Head & Neck Pathology. Introduction CASE 1. Current Issues Tihan
Disclosures I have nothing to disclose The Thin Red Line Between Neuropathology and Head & Neck Pathology Tarik Tihan, MD, PhD UCSF, Department of Pathology Neuropathology Division Introduction Three cases
More informationHistopathological Study and Categorisation of Brain Tumors
Histopathological Study and Categorisation of Brain Tumors Ruchira Wadhwa 1*, Purvi Patel 2, Hansa Goswami 3 1 Third Year Resident, 2 Assistant Professor, 3 Professor and Head, Department of Pathology,
More informationTumors of the Central Nervous System
Tumors of the Central Nervous System 1 Financial Disclosures I have NO SIGNIFICANT FINANCIAL, GENERAL, OR OBLIGATION INTERESTS TO REPORT Introduction General: Brain tumors are lesions that have mass effect
More informationProliferative Epithelial lesions of the Breast. Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London
Proliferative Epithelial lesions of the Breast Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London Amman, November2013 Proliferative Epithelial Lesions of the Breast Usual type
More informationmonotonous, stippled, round, smoothcontoured nuclei and scanty acidophilic or
monotonous, stippled, round, smoothcontoured nuclei and scanty acidophilic or vacuolated cytoplasm. The cells are surrounded by a loose fibrillary stroma that is traversed by delicate capillaries. Ill
More informationFrom a suspicious cystic pineal gland to pineoblastoma in a patient with familial unilateral retinoblastoma
From a suspicious cystic pineal gland to pineoblastoma in a patient with familial unilateral retinoblastoma Marcus C de Jong, Annette C Moll, Sophia Göricke, Paul van der Valk, Wijnanda A Kors, Jonas A
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationEvaluation of the Squash Smear Technique in the Rapid Diagnosis of Central Nervous System Tumors: A Cytomorphological Study
ISPUB.COM The Internet Journal of Pathology Volume 11 Number 1 Evaluation of the Squash Smear Technique in the Rapid Diagnosis of Central Nervous System Tumors: A N Pawar, K Deshpande, S Surase, G D costa,
More informationRapid recurrence of a malignant meningioma: case report
Romanian Neurosurgery Volume XXXI Number 2 2017 April-June Article Rapid recurrence of a malignant meningioma: case report Oguz Baran, Sima Sayyahmeli, Taner Tanriverdi, Pamir Erdincler TURKEY DOI: 10.1515/romneu-2017-0027
More informationintracranial anomalies
Chapter 5: Fetal Central Nervous System 84 intracranial anomalies Hydrocephaly Dilatation of ventricular system secondary to an increase in the amount of CSF. Effects of hydrocephalus include flattening
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationProtocol for management of patients with pineal region tumours v1
Protocol for management of patients with pineal region tumours v1 West Midlands Cancer Alliance Coversheet for Cancer Alliance Expert Advisory Group Agreed Documentation This sheet is to accompany all
More informationPineal Parenchymal Tumors
isclosure of elevant Financial elationships US requires that all faculty in a position to influence or control the content of disclose any relevant financial relationship WH SS which they or their spouse/partner
More informationAria Fallah MD, MSc, FRCSC
Aria Fallah MD, MSc, FRCSC Department of Neurosurgery David Geffen School of Medicine at UCLA Pineal Region Tumors Brain Tumor Symposium August 22, 2015 Disclosures None Pineal Gland Arises from an invagination
More informationLesions of the Pineal Region: A Practical Approach
Lesions of the Pineal Region: A Practical Approach Poster No.: C-0937 Congress: ECR 2013 Type: Educational Exhibit Authors: C. Calles Blanco, J. A. Guzman de Villoria ; Madrid/ES, Madrid, Ma/ES Keywords:
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM MEDULLOBLASTOMA AND PNET CNS Site Group Medulloblastoma and PNET Author: Dr. Norm Laperriere 1. INTRODUCTION 3 2. PREVENTION
More informationCYSTIC TUMORS OF THE KIDNEY JOHN N. EBLE, M.D. CYSTIC NEPHROMA
Page 1 CYSTIC TUMORS OF THE KIDNEY JOHN N. EBLE, M.D. Department of Pathology & Laboratory Medicine Phone (317) 274-4806 Medical Science A-128 FAX: (317) 278-2018 635 Barnhill Drive jeble @iupui.edu Indianapolis,
More informationCase Report Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge
Hindawi Volume 2017, Article ID 6343709, 4 pages https://doi.org/10.1155/2017/6343709 Case Report Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge Mary Anne Brett, Samih Salama,
More informationUniversity Journal of Pre and Para Clinical Sciences
ISSN 2455 2879 Volume 2 Issue 1 2016 Metaplastic carcinoma breast a rare case report Abstract : Metaplastic carcinoma of the breast is a rare malignancy with two distinct cell lines described as a breast
More informationEssentials of Clinical MR, 2 nd edition. 51. Primary Neoplasms
51. Primary Neoplasms As with spinal central canal neoplasms in other regions, those of the lumbar spine may be classified as extradural, intradural extramedullary, and medullary. If an extradural lesion
More informationFive Most Common Problems in Surgical Neuropathology
Five Most Common Problems in Surgical Neuropathology If the brain were so simple that we could understand it, we would be so simple that we couldn t Emerson Pugh What is your greatest difficulty in neuropathology?
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationAnna Maria Buccoliero Department of Biomedicine, Careggi Hospital Florence
PEDIATRIC RHABDOID MENINGIOMA Anna Maria Buccoliero Department of Biomedicine, Careggi Hospital Florence CLINICAL HISTORY A 3-year-old boy, with a recent history of seizures, was admitted to the Neurosurgery
More informationRosette-forming glioneuronal tumor in the pineal gland and the third ventricle: a case with radiological and clinical implications
Case Report Rosette-forming glioneuronal tumor in the pineal gland and the third ventricle: a case with radiological and clinical implications Junqing Xu 1, Yong Yang 1, Ying Liu 1, Mengqi Wei 1, Jing
More informationPediatric Brain Tumors: Updates in Treatment and Care
Pediatric Brain Tumors: Updates in Treatment and Care Writer Classroom Rishi R. Lulla, MD MS Objectives Introduce the common pediatric brain tumors Discuss current treatment strategies for pediatric brain
More informationPleomorphic Xanthoastrocytoma
Pleomorphic Xanthoastrocytoma Christine E. Fuller Keywords Pleomorphic xanthoastrocytoma; Pleomorphic xanthoastrocytoma with anaplastic features 2.1 OVERVIEW Pleomorphic xanthoastrocytoma (PXA) is an uncommon
More informationSynonyms. Nephrogenic metaplasia Mesonephric adenoma
Nephrogenic Adenoma Synonyms Nephrogenic metaplasia Mesonephric adenoma Definition Benign epithelial lesion of urinary tract with tubular, glandular, papillary growth pattern Most frequently in the urinary
More informationEmbryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
745208SCO0010.1177/2050313X17745208SAGE Open Medical Case ReportsTariq et al. case-report2017 Case Report SAGE Open Medical Case Reports Embryonal tumor with multilayered rosettes, C19MC-altered: Report
More informationCase 7391 Intraventricular Lesion
Case 7391 Intraventricular Lesion Bastos Lima P1, Marques C1, Cabrita F2, Barbosa M2, Rebelo O3, Rio F1. 1Neuroradiology, 2Neurosurgery, 3Neuropathology, Coimbra University Hospitals, Portugal. University
More information1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma
2016 MFMER slide-1 2016 MFMER slide-2 2016 MFMER slide-3 Soft Tissue Tumors Showing Melanocytic Differentiation Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester,
More informationMammary analogue secretory carcinoma of salivary gland A case report of new entity
Case Report Mammary analogue secretory carcinoma of salivary gland A case report of new entity Vaibhav Bhika Bari 1*, Sandhya Unmesh Bholay 2 1 Assistant Professor, 2 Associate Professor Rajiv Gandhi Medical
More informationNeurocytoma a Rare Intraventricular Tumor
Neurocytoma a Rare Intraventricular Tumor J. A. Mallick,S. A. Ali ( Department of Oncology, Liaquat National Postgraduate Medical Centre, Karachi. ) Introduction Central neurocytoma was first recognized
More informationCASE year old male with a PET avid nodule in the left adrenal gland
CASE 1 55 year old male with a PET avid nodule in the left adrenal gland Case 1 Adrenal gland parenchyma partly replaced by a spindle cell tumour with mild nuclear pleomorphism Atypical mitoses present
More informationSolid pseudopapillary tumour of the pancreas: Report of five cases
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Solid pseudopapillary tumour of the pancreas: Report of five cases P Srilatha, V Manna, P Kanthilatha Citation P Srilatha, V Manna, P Kanthilatha..
More informationPathological Classification of Hepatocellular Carcinoma
3 rd APASL Single Topic Conference: HCC in 3D Pathological Classification of Hepatocellular Carcinoma Glenda Lyn Y. Pua, M.D. HCC Primary liver cancer is the 2 nd most common cancer in Asia HCC is the
More information04/09/2018. Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances
Salivary Gland Pathology in the Molecular Era Old Friends, Old Foes, & New Acquaintances Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory
More informationAmerican Journal of. Medical Case Reports. CAM5.2 Expression in Metastatic Tumours of CNS: A Diagnostic Tool
American Journal of American Journals of Medical Case Reports http://ivyunion.org/index.php/ajmcr/index Medical Case Reports Mathur SK et al. American Journal of Medical Case Reports 2014, 2:1-8 Vol 2,
More informationCase 1. Maysa Al-Hussaini MD FRCPath
Case 1 Maysa Al-Hussaini MD FRCPath MAYSA King AL-HUSSAINI Hussein Cancer MD Center MRCPATH KING HUSSEIN Amman CANCER Jordan CENTER Clinical history 4 year old boy History of frontal headache, sleepiness.
More informationOptic Pathway Gliomas, Germinomas, Spinal Cord Tumours. Colin Kennedy March 2015
Optic Pathway Gliomas, Germinomas, Spinal Cord Tumours Colin Kennedy March 2015 Glioma of the optic chiasm. T1-weighted MRI with gadolinium enhancement, showing intense irregular uptake of contrast. The
More informationCase Report Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child
Case Reports in Oncological Medicine Volume 2013, Article ID 815923, 4 pages http://dx.doi.org/10.1155/2013/815923 Case Report Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child Y. T.
More informationHAEMANGIOBLASTOMA CASE REPORT
HAEMANGIOBLASTOMA Pages with reference to book, From 113 To 115 Saleem Sadiq, K.C. Kyriacou ( Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. ) Z.B. Jamjoom (
More informationPleomorphic adenoma of breast - a case report and distinction with metaplastic carcinoma D Gupta, S Agrawal, N Trivedi, A Tewari
of breast - a case report and distinction with metaplastic carcinoma D Gupta, S Agrawal, N Trivedi, A Tewari Introduction, also known as mixed tumour, is a benign tumour which typically presents as a painless,
More informationJoana Ramalho, MD C. Ryan Miller, MD, PhD
Joana Ramalho, MD C. Ryan Miller, MD, PhD Case 1 3 month old baby girl Presented with new onset of seizures Newborn. Questionable blurring of the gray-white junction within the right occipital lobe. Findings
More informationInvasive Papillary Breast Carcinoma
410 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license), applicable to the online version of the
More informationRare Presentation Of Adenoidcystic Carcinoma Of External Auditory Canal With Subcutaneous Metastasis In Temporal Region
ISPUB.COM The Internet Journal of Otorhinolaryngology Volume 13 Number 2 Rare Presentation Of Adenoidcystic Carcinoma Of External Auditory Canal With Subcutaneous Metastasis In Temporal Region S Kaushik,
More information04/10/2018. Intraductal Papillary Neoplasms Of Breast INTRADUCTAL PAPILLOMA
Intraductal Papillary Neoplasms Of Breast Savitri Krishnamurthy MD Professor of Pathology Deputy Division Head The University of Texas MD Anderson Cancer Center 25 th Annual Seminar in Pathology Pittsburgh,
More information-The cause of testicular neoplasms remains unknown
- In the 15- to 34-year-old age group, they are the most common tumors of men. - include: I. Germ cell tumors : (95%); all are malignant. II. Sex cord-stromal tumors: from Sertoli or Leydig cells; usually
More informationCase Report Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male
Case Reports in Radiology Volume 2016, Article ID 6434623, 4 pages http://dx.doi.org/10.1155/2016/6434623 Case Report Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male Jordan Nepute,
More informationSite Specific Coding Rules MALIGNANT CENTRAL NERVOUS SYSTEM TUMORS
Multiple Primary and Histology Site Specific Coding Rules MALIGNANT CENTRAL NERVOUS SYSTEM TUMORS 1 Prerequisites 2 Completion of Multiple Primary and Histology General Coding Rules 3 There are many ways
More informationAstroblastoma: Radiologic-Pathologic Correlation and Distinction from Ependymoma
AJNR Am J Neuroradiol 23:243 247, February 2002 Case Report Astroblastoma: Radiologic-Pathologic Correlation and Distinction from Ependymoma John D. Port, Daniel J. Brat, Peter C. Burger, and Martin G.
More informationRecurrent adamantinoma of the tibia and lymph node metastasis
Case Report Recurrent adamantinoma of the tibia and lymph node metastasis Sunil B Gudaganatti, Meena N Jadhav, Rashmi K Patil, Shreekant K Kittur Department of Pathology, Belgaum Institute of Medical Sciences,
More informationBrief History. Identification : Past History : HTN without regular treatment.
Brief History Identification : Name : 陳 x - Admission : 94/10/06 Gender : male Age : 75 y/o Chief Complaint : Urinary difficulty for months. Past History : HTN without regular treatment. Brief History
More informationUpdate on Pediatric Brain Tumors
Update on Pediatric Brain Tumors David I. Sandberg, M.D. Director of Pediatric Neurosurgery & Associate Professor Dr. Marnie Rose Professorship in Pediatric Neurosurgery Pre-talk Questions for Audience
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationPapillary Tumor of the Pineal Region: A Case Report
Case Report Middle East Journal of Cancer; April 2018; 9(2): 165-169 Papillary Tumor of the Pineal Region: A Case Report Hamid Nasrollahi*, Bita Geramizadeh**, Mansour Ansari***, Seyed Hassan Hamedi*,
More informationObjectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells
2013 California Society of Pathologists 66 th Annual Meeting San Francisco, CA Atypical Glandular Cells to Early Invasive Adenocarcinoma: Cervical Cytology and Histology Christina S. Kong, MD Associate
More informationDisclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012
Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features
More informationDisorders of Cell Growth & Neoplasia. Histopathology Lab
Disorders of Cell Growth & Neoplasia Histopathology Lab Paul Hanna April 2010 Case #84 Clinical History: 5 yr-old, West Highland White terrier. skin mass from axillary region. has been present for the
More informationCase Report Disseminated Cerebrospinal Embryonal Tumor in the Adult
Case Reports in Pathology Volume 2016, Article ID 6785459, 5 pages http://dx.doi.org/10.1155/2016/6785459 Case Report Disseminated Cerebrospinal Embryonal Tumor in the Adult Alessandro Caporlingua, 1 Daniele
More informationPrepared By Jocelyn Palao and Layla Faqih
Prepared By Jocelyn Palao and Layla Faqih The structure of the suspected atypical cell should always be compared to the structure of other similar, benign, cells which are present in the smears. The diagnosis
More informationImaging Spectrum of Unusual Pineal Region Masses: A Short Series of Four Cases
THIEME Case Report 135 Imaging Spectrum of Unusual Pineal Region Masses: A Short Series of Four Cases Anandamoyee Dhar 1 Ruchi Jain 1 Bipin Walia 2 Urmi Mukherjee 3 Bharat Aggarwal 1 1 Department of Radio-Diagnosis,
More informationDiseases of the breast (1 of 2)
Diseases of the breast (1 of 2) Introduction A histology introduction Normal ducts and lobules of the breast are lined by two layers of cells a layer of luminal cells overlying a second layer of myoepithelial
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationDISCUSSION: PLGA accounts for about 2% of all salivary gland tumours and occurs almost exclusively in the minor salivary glands.
SWELLING ON THE HARD PALATE PRESENTING AS POLYMORPHOUS LOW GRADE ADENOCARCINOMA: A AND REVIEW OF LITERATURE Swapnil D. Chandekar 1, Sunita S. Dantkale 2, Rahul R. Narkhede 3, Snehal V. Chavhan 4, Khushboo
More informationStructural and functional imaging for the characterization of CNS lymphomas
Structural and functional imaging for the characterization of CNS lymphomas Cristina Besada Introduction A few decades ago, Primary Central Nervous System Lymphoma (PCNSL) was considered as an extremely
More informationInternational Journal of Pharma and Bio Sciences CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY.
Case Report Pathology International Journal of Pharma and Bio Sciences ISSN 0975-6299 CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY. DR.MAMATHA K*, DR. ARAKERI
More informationAstroblastoma : A Case Report
J Korean Med Sci 2004; 19: 772-6 ISSN 1011-8934 Copyright The Korean Academy of Medical Sciences Astroblastoma : A Case Report Astroblastoma is one of the very unusual type of tumors, whose histogenesis
More informationOMICS PUBLISHING GROUP/Clinical Meningioma with remarkable multiple rosette formation: A diagnostically difficult case
OMICS PUBLISHING GROUP/Clinical Meningioma with remarkable multiple rosette formation: A diagnostically difficult case --Manuscript Draft-- Manuscript Number: Full Title: Short Title: Article Type: Section/Category:
More informationSTUDY OFPAEDIATRIC CNS TUMORS IN TERTIARY CARE CENTER
IJCRR Section: Healthcare Sci. Journal Impact Factor 4.016 Original Article STUDY OFPAEDIATRIC CNS TUMORS IN TERTIARY CARE CENTER Grishma P. Jobanputra Tutor, Department of Pathology, B.J. Medical College,
More informationCase Report Tackling a Recurrent Pinealoblastoma
Case Reports in Oncological Medicine, Article ID 135435, 4 pages http://dx.doi.org/10.1155/2014/135435 Case Report Tackling a Recurrent Pinealoblastoma Siddanna Palled, 1 Sruthi Kalavagunta, 1 Jaipal Beerappa
More informationOncocytic carcinoma: A rare malignancy of the parotid gland
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Oncocytic carcinoma: A rare malignancy of the parotid gland K Mardi, J Sharma Citation K Mardi, J Sharma.. The Internet Journal of Pathology.
More informationTriple Negative Breast Cancer
Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional
More informationTesticular Germ Cell Tumors; A Simplistic Approach
Testicular Germ Cell Tumors; A Simplistic Approach Merce Jorda, MD, PhD, MBA Professor and Vice Chair, Director of Anatomic Pathology Director of Genitourinary Pathology Service Interim Director of Cytopathology
More information3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:
Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position
More informationKidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationA 25 year old female with a palpable mass in the right lower quadrant of her abdomen
May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and
More informationFinancial Disclosures I have no financial interests to disclose. Templar Eye Foundation Oppenheimer Family Foundation
Financial Disclosures I have no financial interests to disclose. Templar Eye Foundation Oppenheimer Family Foundation 2 Case 7 year old girl Initially parents noticed photophobia Then started to complain
More informationRecommendations for cross-sectional imaging in cancer management, Second edition
www.rcr.ac.uk Recommendations for cross-sectional imaging in cancer management, Second edition Tumours of the spinal cord Faculty of Clinical Radiology www.rcr.ac.uk Contents Primary spinal cord tumours
More informationDisclosure. Relevant Financial Relationship(s) None. Off Label Usage None MFMER slide-1
Disclosure Relevant Financial Relationship(s) None Off Label Usage None 2013 MFMER slide-1 Case Presentation A 43 year old male, with partial nephrectomy for a right kidney mass 2013 MFMER slide-2 2013
More informationBrain tumors: tumor types
Brain tumors: tumor types Tumor types There are more than 120 types of brain tumors. Today, most medical institutions use the World Health Organization (WHO) classification system to identify brain tumors.
More information