Recurrent Glioblastoma Multiforme (GBM) - Pipeline Review, H1 2016

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1 Published on Market Research Reports Inc. ( Home > Recurrent Glioblastoma Multiforme (GBM) - Pipeline Review, H Recurrent Glioblastoma Multiforme (GBM) - Pipeline Review, H Publication ID: GMD Publication April 20, 2016 Date: Pages: 434 Publisher: Global Markets Direct Countries: Global [1] $2, Publication Type * - Select - Please choose the suitable license type from above. More details are at given under tab "Report License Types" below. Add to cart Diseases [2] Pharma & Healthcare [3]

2 Description: Recurrent Glioblastoma Multiforme (GBM) - Pipeline Review, H Summary Global Markets Direct s, Recurrent Glioblastoma Multiforme (GBM) - Pipeline Review, H1 2016, provides an overview of the Recurrent Glioblastoma Multiforme (GBM) pipeline landscape. The report provides comprehensive information on the therapeutics under development for Recurrent Glioblastoma Multiforme (GBM), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Recurrent Glioblastoma Multiforme (GBM) and features dormant and discontinued projects. Global Markets Direct s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data. Scope - The report provides a snapshot of the global therapeutic landscape of Recurrent Glioblastoma Multiforme (GBM) - The report reviews pipeline therapeutics for Recurrent Glioblastoma Multiforme (GBM) by companies and universities/research institutes based on information derived from company and industry-specific sources - The report covers pipeline products based on various stages of development ranging from preregistration till discovery and undisclosed stages - The report features descriptive drug profiles for the pipeline products which includes, product

3 description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved Recurrent Glioblastoma Multiforme (GBM) therapeutics and enlists all their major and minor projects - The report assesses Recurrent Glioblastoma Multiforme (GBM) therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type - The report summarizes all the dormant and discontinued pipeline projects - The report reviews latest news related to pipeline therapeutics for Recurrent Glioblastoma Multiforme (GBM) Reasons to buy - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies - Identify emerging players with potentially strong product portfolio and create effective counterstrategies to gain competitive advantage - Identify and understand important and diverse types of therapeutics under development for Recurrent Glioblastoma Multiforme (GBM) - Identify potential new clients or partners in the target demographic - Develop strategic initiatives by understanding the focus areas of leading companies - Plan mergers and acquisitions effectively by identifying key players and it s most promising pipeline therapeutics - Devise corrective measures for pipeline projects by understanding Recurrent Glioblastoma Multiforme (GBM) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline Table Of Contents: Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Recurrent Glioblastoma Multiforme (GBM) Overview 9 Therapeutics Development 10 Pipeline Products for Recurrent Glioblastoma Multiforme (GBM) Overview 10 Pipeline Products for Recurrent Glioblastoma Multiforme (GBM) Comparative Analysis 11

4 Recurrent Glioblastoma Multiforme (GBM) Therapeutics under Development by Companies 12 Recurrent Glioblastoma Multiforme (GBM) Therapeutics under Investigation by Universities/Institutes 15 Recurrent Glioblastoma Multiforme (GBM) Pipeline Products Glance 16 Late Stage Products 16 Clinical Stage Products 17 Early Stage Products 18 Recurrent Glioblastoma Multiforme (GBM) Products under Development by Companies 19 Recurrent Glioblastoma Multiforme (GBM) Products under Investigation by Universities/Institutes 23 Recurrent Glioblastoma Multiforme (GBM) Companies Involved in Therapeutics Development 24 AbbVie Inc. 24 Agenus, Inc. 25 Amgen Inc. 26 AngioChem Inc. 27 Apogenix GmbH 28 AstraZeneca Plc 29 Axelar AB 30 BeiGene, Ltd. 31 Boehringer Ingelheim GmbH 32 Boston Biomedical, Inc. 33 Bristol-Myers Squibb Company 34 Cantex Pharmaceuticals, Inc. 35 Cavion LLC 36 Celldex Therapeutics, Inc. 37 Coherus BioSciences, Inc. 38 Cortice Biosciences, Inc. 39 Eisai Co., Ltd. 40 Eli Lilly and Company 41 EnGeneIC Ltd 42 ERC Belgium SA 43 GenSpera, Inc. 44 Genzyme Corporation 45 GW Pharmaceuticals Plc 46 ImmunoCellular Therapeutics, Ltd. 47 Karyopharm Therapeutics, Inc. 48 Les Laboratoires Servier SAS 49 Medicenna Therapeutics, Inc. 50 Merck & Co., Inc. 51 Novartis AG 52

5 Ono Pharmaceutical Co., Ltd. 53 Oryx GmbH & Co. KG 54 Pfizer Inc. 55 Stemline Therapeutics, Inc. 56 Threshold Pharmaceuticals, Inc. 57 Tocagen Inc. 58 TRACON Pharmaceuticals, Inc. 59 Vascular Biogenics Ltd. 60 Vaximm AG 61 Virttu Biologics Limited 62 Recurrent Glioblastoma Multiforme (GBM) Therapeutics Assessment 63 Assessment by Monotherapy Products 63 Assessment by Combination Products 64 Assessment by Target 65 Assessment by Mechanism of Action 69 Assessment by Route of Administration 72 Assessment by Molecule Type 74 Drug Profiles 76 (GWP GWP-42003) - Drug Profile 76 abemaciclib - Drug Profile 77 acalabrutinib - Drug Profile 79 afatinib dimaleate - Drug Profile 82 AMG Drug Profile 87 asinercept - Drug Profile 89 AU Drug Profile 91 AU Drug Profile 92 axitinib - Drug Profile 93 AXL Drug Profile 97 AZD Drug Profile 99 bevacizumab biosimilar - Drug Profile 100 BGB Drug Profile 101 bosutinib - Drug Profile 103 buparlisib hydrochloride - Drug Profile 106 capmatinib - Drug Profile 110 Cellular Immunotherapy for Recurrent Glioblastoma Multiforme - Drug Profile 113 Cellular Immunotherapy to Target Interleukein 13 Receptor Alpha-2 for Acute Myelocytic Leukemia and Glioblastoma Multiforme - Drug Profile 114 CX-02 - Drug Profile 115 dacomitinib - Drug Profile 116 dasatinib - Drug Profile 119

6 depatuxizumab mafodotin - Drug Profile 122 DNX Drug Profile 124 ERC Drug Profile 127 evofosfamide - Drug Profile 129 flucytosine ER + vocimagene amiretrorepvec - Drug Profile 137 G Drug Profile 140 galunisertib - Drug Profile 142 golvatinib + lenvatinib - Drug Profile 144 golvatinib tartrate - Drug Profile 146 HSV Drug Profile 148 ICT Drug Profile 151 infigratinib - Drug Profile 153 lenvatinib mesylate - Drug Profile 154 lonafarnib - Drug Profile 160 MDNA-55 - Drug Profile 162 mibefradil dihydrochloride - Drug Profile 163 mipsagargin - Drug Profile 165 nabiximols - Drug Profile 167 napabucasin - Drug Profile 171 NEO Drug Profile 174 nilotinib - Drug Profile 176 nivolumab - Drug Profile 180 ofranergene obadenovec - Drug Profile 188 ONC Drug Profile 190 Oncolytic Virus for Oncology - Drug Profile 193 Oncolytic Virus to Target Carcinoembryonic Antigen for Oncology - Drug Profile 194 Oncolytic Virus to Target IL-12 for Oncology - Drug Profile 196 OS Drug Profile 197 p28 - Drug Profile 198 paclitaxel trevatide - Drug Profile 200 Parvoryx - Drug Profile 202 pazopanib hydrochloride - Drug Profile 203 pembrolizumab - Drug Profile 209 ramucirumab - Drug Profile 219 rilotumumab - Drug Profile 225 rindopepimut - Drug Profile 227 S Drug Profile 229 selinexor - Drug Profile 230 SGT-53 - Drug Profile 236 SL Drug Profile 238

7 sonidegib phosphate - Drug Profile 240 TPI Drug Profile 244 TRC Drug Profile 247 trebananib - Drug Profile 249 vandetanib - Drug Profile 252 VEDVDox - Drug Profile 258 vorinostat - Drug Profile 259 VXM-01 - Drug Profile 263 Recurrent Glioblastoma Multiforme (GBM) Recent Pipeline Updates 265 Recurrent Glioblastoma Multiforme (GBM) - Dormant Projects 415 Recurrent Glioblastoma Multiforme (GBM) Discontinued Products 417 Recurrent Glioblastoma Multiforme (GBM) Product Development Milestones 418 Featured News & Press Releases 418 Appendix 428 Methodology 428 Coverage 428 Secondary Research 428 Primary Research 428 Expert Panel Validation 428 Contact Us 428 Disclaimer 429 List of Tables Number of Products under Development for Recurrent Glioblastoma Multiforme (GBM), H Number of Products under Development for Recurrent Glioblastoma Multiforme (GBM) Comparative Analysis, H Number of Products under Development by Companies, H Number of Products under Development by Companies, H (Contd..1) 18 Number of Products under Development by Companies, H (Contd..2) 19 Number of Products under Investigation by Universities/Institutes, H Comparative Analysis by Late Stage Development, H Comparative Analysis by Clinical Stage Development, H Comparative Analysis by Early Stage Development, H Products under Development by Companies, H Products under Development by Companies, H (Contd..1) 25 Products under Development by Companies, H (Contd..2) 26 Products under Development by Companies, H (Contd..3) 27 Products under Investigation by Universities/Institutes, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by AbbVie Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Agenus, Inc., H

8 Recurrent Glioblastoma Multiforme (GBM) Pipeline by Amgen Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by AngioChem Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Apogenix GmbH, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by AstraZeneca Plc, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Axelar AB, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by BeiGene, Ltd., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Boehringer Ingelheim GmbH, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Boston Biomedical, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Bristol-Myers Squibb Company, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Cantex Pharmaceuticals, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Cavion LLC, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Celldex Therapeutics, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Coherus BioSciences, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Cortice Biosciences, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Eisai Co., Ltd., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Eli Lilly and Company, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by EnGeneIC Ltd, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by ERC Belgium SA, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by GenSpera, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Genzyme Corporation, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by GW Pharmaceuticals Plc, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by ImmunoCellular Therapeutics, Ltd., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Karyopharm Therapeutics, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Les Laboratoires Servier SAS, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Medicenna Therapeutics, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Merck & Co., Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Novartis AG, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Ono Pharmaceutical Co., Ltd., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Oryx GmbH & Co. KG, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Pfizer Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Stemline Therapeutics, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Threshold Pharmaceuticals, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Tocagen Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by TRACON Pharmaceuticals, Inc., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Vascular Biogenics Ltd., H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Vaximm AG, H Recurrent Glioblastoma Multiforme (GBM) Pipeline by Virttu Biologics Limited, H Assessment by Monotherapy Products, H Assessment by Combination Products, H

9 Number of Products by Stage and Target, H Number of Products by Stage and Mechanism of Action, H Number of Products by Stage and Route of Administration, H Number of Products by Stage and Molecule Type, H Recurrent Glioblastoma Multiforme (GBM) Therapeutics Recent Pipeline Updates, H Recurrent Glioblastoma Multiforme (GBM) Dormant Projects, H Recurrent Glioblastoma Multiforme (GBM) Dormant Projects (Contd..1), H Recurrent Glioblastoma Multiforme (GBM) Discontinued Products, H List of Figures Number of Products under Development for Recurrent Glioblastoma Multiforme (GBM), H Number of Products under Development for Recurrent Glioblastoma Multiforme (GBM) Comparative Analysis, H Number of Products under Development by Companies, H Number of Products under Investigation by Universities/Institutes, H Comparative Analysis by Clinical Stage Development, H Assessment by Monotherapy Products, H Assessment by Combination Products, H Number of Products by Top 10 Targets, H Number of Products by Stage and Top 10 Targets, H Number of Products by Top 10 Mechanism of Actions, H Number of Products by Stage and Top 10 Mechanism of Actions, H Number of Products by Top 10 Routes of Administration, H Number of Products by Stage and Top 10 Routes of Administration, H Number of Products by Top 10 Molecule Types, H Number of Products by Stage and Top 10 Molecule Types, H Companies Mentioned: AbbVie Inc. Agenus, Inc. Amgen Inc. AngioChem Inc. Apogenix GmbH AstraZeneca Plc Axelar AB BeiGene, Ltd. Boehringer Ingelheim GmbH Boston Biomedical, Inc. Bristol-Myers Squibb Company Cantex Pharmaceuticals, Inc.

10 Cavion LLC Celldex Therapeutics, Inc. Coherus BioSciences, Inc. Cortice Biosciences, Inc. Eisai Co., Ltd. Eli Lilly and Company EnGeneIC Ltd ERC Belgium SA GenSpera, Inc. Genzyme Corporation GW Pharmaceuticals Plc ImmunoCellular Therapeutics, Ltd. Karyopharm Therapeutics, Inc. Les Laboratoires Servier SAS Medicenna Therapeutics, Inc. Merck & Co., Inc. Novartis AG Ono Pharmaceutical Co., Ltd. Oryx GmbH & Co. KG Pfizer Inc. Stemline Therapeutics, Inc. Threshold Pharmaceuticals, Inc. Tocagen Inc. TRACON Pharmaceuticals, Inc. Vascular Biogenics Ltd. Vaximm AG Virttu Biologics Limited License Types: Single User License (PDF) This license allows for use of a publication by one person. This person may print out a single copy of the publication. This person can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. This person cannot share the publication (or any information contained therein) with any other person or persons. Unless a Enterprise License is purchased, a Single User License must be purchased for every person that wishes to use the publication within the same organization. Customers who infringe these license terms are liable for a Global license fee.

11 Site License (PDF)* This license allows for use of a publication by all users within one corporate location, e.g. a regional office. These users may print out a single copy of the publication. These users can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. These users cannot share the publication (or any information contained therein) with any other person or persons outside the corporate location for which the publication is purchased. Unless a Enterprise License is purchased, a Site User License must be purchased for every corporate location by an organization that wishes to use the publication within the same organization. Customers who infringe these license terms are liable for a Global license fee. Global License (PDF)* This license allows for use of a publication by unlimited users within the purchasing organization e.g. all employees of a single company. Each of these people may use the publication on any computer, and may print out the report, but may not share the publication (or any information contained therein) with any other person or persons outside of the organization. These employees of purchasing organization can include information given in the publication in presentations and internal reports by providing full copyright credit to the publisher. *If Applicable. Source URL: Links [1] [2] [3]

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