Chordoid Glioma Originating in the Intrasellar and Suprasellar Regions: Case Report

Size: px
Start display at page:

Download "Chordoid Glioma Originating in the Intrasellar and Suprasellar Regions: Case Report"

Transcription

1 pissn eissn imri 2015;19: Chordoid Gliom Originting in the Intrsellr nd Suprsellr Regions: Cse Report Jisun Hwng 1, Aleum Lee 1, Kee-Hyun Chng 1, Ah Rim Moon 2, Sun-Chul Hwng 3, Hyun Sook Hong 1 1 Deprtment of Rdiology, Soonchunhyng University Bucheon Hospitl, Bucheon, Kore 2 Deprtment of Pthology, Soonchunhyng University Bucheon Hospitl, Bucheon, Kore 3 Deprtment of Neurosurgery, Soonchunhyng University Bucheon Hospitl, Bucheon, Kore Cse Report Received: April 2, 2015 Revised: April 22, 2015 Accepted: My 10, 2015 Correspondence to: Aleum Lee, M.D. Deprtment of Rdiology, Soonchunhyng University Bucheon Hospitl, Soonchunhyng University College of Medicine, 170 Jomruro, Wonmi-gu, Bucheon , Kore. Tel Fx Emil: leerd@schmc.c.kr This is n Open Access rticle distriuted under the terms of the Cretive Commons Attriution Non-Commercil License ( y-nc/3.0/) which permits unrestricted non-commercil use, distriution, nd reproduction in ny medium, provided the originl work is properly cited. Copyright 2015 Koren Society of Mgnetic Resonnce in Medicine (KSMRM) Chordoid gliom is rre, low-grde rin neoplsm typiclly locted in the third ventricle. Herein, we report n unusul cse of histologiclly confirmed chordoid gliom locted in the pituitry foss nd suprsellr region, not ttched to the third ventricle. A 57-yer-old womn presented with 2-month history of hedche nd visul disturnce. Mgnetic resonnce imging reveled n ovoid mss in the pituitry foss nd suprsellr region, compressing the optic chism without involvement of the third ventricle. The tumor showed low signl intensity on T1- weighted imges nd iso- to high signl intensity on T2-weighted imges, with strong nd homogenous contrst enhncement. Sutotl resection ws performed vi the trnscrnil pproch, nd the ptient susequently received djuvnt gmm knife rdiosurgery. However, the residul mss showed disese progression 5 months fter the initil surgery. Keywords: Chordoid gliom; Third ventricle; Rdiologicl feture; Mgnetic resonnce imging INTRODUCTION Chordoid gliom (CG) is n uncommon, slow-growing primry rin neoplsm, first descried s distinct clinicopthologic entity y Brt et l. (1) in CG ws nmed for its histologic fetures, which resemle those of chordoms expressing glil firillry cidic protein (GFAP) (1). It ws incorported into the World Helth Orgniztion clssifiction s grde 2 lesion under the ctegory of glil tumor of uncertin origin. CG exclusively involves res of the nterior portion of the third ventricle ner the hypothlmus (2). The tumor is termed s CG of the third ventricle ecuse of this stereotypicl loction, nd only few cses of extrventriculr CG hve een reported (3, 4). To the est of our knowledge, 23 cses of suprsellr CG hve een reported to dte, including the current cse. Of these, only few cses of CG were loclized to the suprsellr region without ventriculr involvement (4). Although few previous reports hve descried the typicl rdiologic nd histopthologic fetures of CG, none of the reports focused on the rdio-pthologicl correltion. This is the first report providing comprehensive rdio-pthologicl correltion of pituitry mcrodenom-like 117

2 Chordoid Gliom in the Intr- nd Supr-sellr Regions Jisun Hwng, et l. extrventriculr CG unusully locted in the sellr nd suprsellr regions. CASE REPORT A 57-yer-old womn presented with 2-month history of hedches nd visul disturnce. Neurologicl exmintion reveled itemporl heminopsi. Hed computed tomogrphy (CT) demonstrted well-circumscried ovl mss without clcifiction or cystic components in the sellr nd suprsellr regions. It ppered hyperdense nd showed strong homogenous enhncement (Fig. 1, ). Mgnetic resonnce imging (MRI) reveled cm mss in the pituitry foss nd suprsellr region, which ws elevting nd compressing the optic chism nd the floor of the third ventricle superiorly without tumor extension. The norml pituitry glnd nd stlk were not discernile. The tumor ws hypointense on T1-weighted imges, iso- to hyperintense on T2-weighted imges, nd hyperintense fter gdolinium dministrtion (Fig. 2d). Presumptive dignoses were pituitry mcrodenom, meningiom, or crniophryngiom. The ptient underwent surgery vi the trnscllosl pproch. During surgery, the mss ppered to originte from the diphrgm selle ehind the optic chism, nd it ws not utting the third ventricle. Moreover, the pituitry stlk ws encsed y the tumor. The mss ws prtilly resected ecuse of the difficult surgicl pproch to the posterior portion of the mss. Histologiclly, the tumor ws composed of epithelioid-to-spindle cells rrnged in clusters nd cords, emedded in myxoid mtrix (Fig. 3). The neoplstic cells showed strong diffuse immunorectivity for GFAP (Fig. 3), CD34, nd vimentin. A smll suset of neoplstic cells stined positive for S100, cytokertin, nd epithelil memrne ntigen; however, stining for synptophysin ws negtive. The Ki-67 index ws pproximtely 15%. The differentil dignoses sed on tumor histology were CG, chordoid meningiom, nd chordom. Meningiom nd chordom were excluded sed on the strong GFAP expression; CD34 immunorectivity lso supported the dignosis of CG. The Ki-67 index reflected reltively high prolifertion rte, compred to previously reported rtes. Prtil improvement in visul function ws noted postopertively; however, the ptient developed memory nd git disturnce. Postopertive CT reveled residul mss nd hydrocephlus. The ptient underwent ventriculoperitonel shunt plcement nd received djuvnt gmm knife rdiosurgery. The hydrocephlus stilized, ut the lst ville follow-up MRI scn otined 5 months fter the initil resection reveled disese progression with tumor growth. DISCUSSION First, Brt et l. (1) identified tumor of the third ventricle presenting with oth glil nd chordoid fetures in 1998, nd new rre clinicopthologicl entity ws nmed Fig. 1. An xil precontrst () nd contrst-enhnced () computed tomogrphy scn show n ovl, well-defined, nd hyperdense mss with strong nd homogenous enhncement in the sellr nd suprsellr regions. 118

3 c d s "chordoid gliom of the third ventricle" (3). Since then, to our knowledge, pproximtely 84 cses hve een reported. The tumor develops minly in dults, with 1.7:1 femle predominnce, nd men ge t presenttion is 44.9 yers (5). The most common symptom is hedche; other symptoms include visul disturnce, memory disturnce, nd endocrine dysfunction. CGs exhiit remrkly similr chrcteristics on rin imging (2); the tumor exclusively involves res of the nterior portion of the third ventricle ner the hypothlmus. A few exceptionl cses with unusul loctions such s the juxtventriculr region, left temporoprietl cortex, nd thlmic pulvinr re (3) hve een reported. On CT, the lesions re well circumscried nd hyperttenuting, with uniform contrst enhncement. On MRI, CGs re isointense on T1-weighted imges, with vid nd uniform contrst enhncement fter gdolinium dministrtion, nd iso- to hyperintense on T2-weighted Fig. 2. Mgnetic resonnce imges of the tumor. () Sgittl T1weighted imge shows low signl intensity of the mss. () Coronl T2-weighted imge shows isoto high signl intensity of the mss. Coronl (c) nd sgittl (d) contrst-enhnced T1-weighted imges of the rin revel strong, homogeneously enhncing solid sellr nd suprsellr mss, not connected to the third ventricle. The norml pituitry glnd nd stlk re not discernile. The epicenter of the mss ppers to originte in the sell, nd not in the lmin terminlis of the nterior third ventricle. imges. This significnt contrst enhncement of CG is thought to rise from lood-rin rrier rekdown nd the ensuing extrvstion of contrst medium, rther thn tumor ngiogenesis, which is confirmed y the lck of vsculr prolifertion on histologicl exmintion (6). On sgittl imges, infundiulum shows posterior displcement y the tumor nd gretest dimeter of this tumor is usully oserved in the superoinferior orienttion (2). Intrlesionl clcifiction is rre. Cystic chnges re occsionlly oserved (2). CGs re typiclly well-circumscried nd noninfiltrtive tumors tht re confined to the ventricle, ut rre cse of tumor invsion into the optic chism hs een reported (7). Typicl histopthologic findings of CG include the following: 1) clusters nd cords of ovl-to-polygonl epithelioid tumor cells with undnt eosinophilic cytoplsm, emedded in PAS-positive mucinous mtrix; 2) prominent lymphoplsmcytic infiltrtes nd Russell 119

4 Chordoid Gliom in the Intr- nd Supr-sellr Regions Jisun Hwng, et l. Fig. 3. Histologicl fetures of the tumor. () The tumor shows clusters nd cords of epithelioid-to-spindle cells emedded in myxoid mtrix nd inflmmtory cells (Hemtoxylin & Eosin stining, originl mgnifiction 100). () The positive immunorectivity for glil firillry cidic protein expression re visulized s rown (originl mgnifiction 200). odies throughout the tumor; 3) mitotic ctivity nd nplstic fetures (nucler polymorphism, endothelil prolifertion, necrosis) re sent or rre; nd 4) minor tendency to infiltrte the surrounding rin prenchym; however, rective strocytes, Rosenthl fiers, nd chronic inflmmtory cells re present in djcent rin tissue (1). Although mny pulished cses hve shown consistent histopthologic nd rdiologicl fetures of CG, no report hs specificlly discussed the correltion etween typicl imging fetures nd the histologicl fetures of CG. The CGs re usully hyperdense on non-enhnced CT imges. We elieve tht the hyperdensity is proly relted to the incresed cellulrity of these lesions, owing to prominent lymphoplsmcytic infiltrtes. Moreover, the reltive iso-to hyperintensity of CGs on T2-weighted imges my reflect the presence of undnt eosinophilic cytoplsm in tumor cells nd the undnt mucinous mtrix. The precise pthogenesis of CGs remins uncler. However, severl recent ultrstructurl studies hve proposed n ependyml origin for these tumors (3, 5, 8). In the 3 cses studied y Cencchi et l. (8), the uthors suggest tht CGs my e n ependymom sutype, sed on the ultrstructurl similrities etween CGs nd the specilized ependyml cells of the sucommissurl orgn, which is prominent during emryologic life ut undergoes progressive involution. Psquier et l. (5) proposed the term chordoid ependymom of the lmin terminlis re, sed on the ultrstructurl findings nd remrkly consistent ntomic loction of this tumor in the nterior prt of the third ventricle, closely ssocited with the lmin terminlis, ner severl circumventriculr orgns. Of note, in the current cse, neuroimging studies reveled tht the tumor ppered s solid sellr nd suprsellr mss, independent of the third ventricle, nd ppered to mimic pituitry mcrodenoms. Moreover, the epicenter of the mss s ppered to originte in the sell, nd not from the lmin terminlis in the nterior third ventricle. To the est of our knowledge, 23 cses of suprsellr CG hve een reported. Of these, only few cses of CG were loclized to the suprsellr region without ventriculr involvement (4), s seen in this cse. Furthermore, only one cse ws reported to e loclized to the sellr nd suprsellr regions without ventriculr involvement, mimicking pituitry mcrodenom, s oserved in our cse (4). On MRI, clssic CG cn e clerly distinguished from the pituitry glnd nd stlk, excluding the possiility of pituitry denom (6). However, in the current cse, the tumor could not e distinguished from the pituitry glnd nd stlk, prompting the preopertive dignosis of pituitry mcrodenom. This unique loction of current tumor leds to confusion with other sell nd suprsell pthologies. Vrious pthologic entities cn rise in the sellr or suprsellr region, nd common etiologies of msses involving oth the sellr nd suprsellr spces include pituitry mcrodenom, crniophryngiom, Rthke cleft 120

5 cyst, nd meningiom (9). Pituitry denoms re the most common lesion involving the suprsellr region. Although their chrcteristics of signl intensity or enhncement re not distinctive, fetures such s sellr enlrgement nd erosion, cvernous sinus invsion, nd loulted mrgins re helpful in dignosing pituitry denoms (9). Crniophryngioms often hve degenertive clcifiction nd prominent cystic component. In ddition, In ddition, one-third of crniophryngioms re heterogeneously hyperintense on T1-weighted MRI scns nd show heterogeneous contrst enhncement in the solid portions nd cyst wll. In contrst, CGs rrely show clcifiction, nd stereotypiclly show homogenous contrst enhncement (9). On CT, CG my e confused with meningiom owing to its hyperdensity, nd homogenous strong enhncement fter contrst dministrtion. Moreover, the reltive isointensity of CG is similr to tht of meningiom in T2- weighted imges. However, the ilterlly symmetric posterior extension of vsogenic edem into the optic trcts my fcilitte the differentil dignosis (2). Moreover, meningioms frequently crete n otuse ngle with the tuerculum or dorsum selle (67%), show the durl til sign or meningel enhncement (68%), nd re commonly ssocited with hyperostosis when the sell is involved (34%) (9). CGs re reported to hve poor prognosis. It ws reported tht 74% of ptients with CG died from postopertive complictions or tumor recurrence; the most common cuse of deth ws pulmonry emolism (10). Sutotl resection is ssocited with the risk of recurrence. Adjuvnt rdition therpy hs een performed in limited numer of cses; Koyshi et l. (10) reported effective residul tumor control with gmm knife rdiosurgery in three ptients. We present n unusul cse of CG locted in the pituitry foss nd suprsellr region without involvement of the third ventricle, which ppered to mimic pituitry mcrodenom. We recommend tht the differentil dignoses for lesions in the sellr nd suprsellr regions should e extended to include CGs in the list of possile etiologies. Acknowledgments This work ws supported in prt y the Soonchunhyng University Reserch Fund. REFERENCES 1. Brt DJ, Scheithuer BW, Stugitis SM, Cortez SC, Brecher K, Burger PC. Third ventriculr chordoid gliom: distinct clinicopthologic entity. J Neuropthol Exp Neurol 1998;57: Pomper MG, Psse TJ, Burger PC, Scheithuer BW, Brt DJ. Chordoid gliom: neoplsm unique to the hypothlmus nd nterior third ventricle. AJNR Am J Neurordiol 2001;22: Kim JW, Kim JH, Choe G, Kim CY. Chordoid gliom: cse report of unusul loction nd neurordiologicl chrcteristics. J Koren Neurosurg Soc 2010;48: Suh YL, Kim NR, Kim JH, Prk SH. Suprsellr chordoid gliom comined with Rthke's cleft cyst. Pthol Int 2003;53: Psquier B, Peoc'h M, Morrison AL, et l. Chordoid gliom of the third ventricle: report of two new cses, with further evidence supporting n ependyml differentition, nd review of the literture. Am J Surg Pthol 2002;26: Grnd S, Psquier B, Gy E, Kremer S, Remy C, Le Bs JF. Chordoid gliom of the third ventricle: CT nd MRI, including perfusion dt. Neurordiology 2002;44: Al Hini QS, Petrecc K. Rrest of the rre: chordoid gliom infiltrting the optic chism. Surg Neurol Int 2011;2:53 8. Cencchi G, Roncroli F, Cersoli S, Ficrr G, Merli GA, Gingspero F. Chordoid gliom of the third ventricle: n ultrstructurl study of three cses with histogenetic hypothesis. Am J Surg Pthol 2001;25: Donovn JL, Nesit GM. Distinction of msses involving the sell nd suprsellr spce: specificity of imging fetures. AJR Am J Roentgenol 1996;167: Koyshi T, Tsugw T, Hshizume C, et l. Therpeutic pproch to chordoid gliom of the third ventricle. Neurol Med Chir (Tokyo) 2013;53:

A Rare Manifestation of Solitary Primary Bone Lymphoma of the Finger: a Case Report

A Rare Manifestation of Solitary Primary Bone Lymphoma of the Finger: a Case Report pissn 2384-1095 eissn 2384-1109 imri 2018;22:240-244 A Rre Mnifesttion of Solitry Primry Bone Lymphom of the Finger: Cse Report Jeong A Yeom 2, You Seon Song 1 *, In Sook Lee 1, Kyung Un Choi 3, Jeung

More information

Seeding Metastasis of Chromophobe Renal Cell Carcinoma after Robot-Assisted Laparoscopic Partial Nephrectomy

Seeding Metastasis of Chromophobe Renal Cell Carcinoma after Robot-Assisted Laparoscopic Partial Nephrectomy pissn 2384-1095 eissn 2384-1109 imri 2017;21:119-124 https://doi.org/10.13104/imri.2017.21.2.119 Seeding Metstsis of Chromophoe Renl Cell Crcinom fter Root-Assisted Lproscopic Prtil Nephrectomy Knghun

More information

Intraventricular CNS lesions: A pictorial essay

Intraventricular CNS lesions: A pictorial essay s_s_nner Journl of Medicl Imging nd Rdition Oncology 59 (2015) 453 460 MEDICAL IMAGING PICTORIAL ESSAY Intrventriculr CNS lesions: A pictoril essy Jne Wtts, 1 Kelvin K Yp, 1 Dniel Ou, 2 Con Trtgli, 1 Nichols

More information

Anus,Rectum and Colon

Anus,Rectum and Colon JOURNAL OF THE Anus,Rectum nd Colon http://journl-rc.jp CASE REPORT Anl Cnl Dupliction Associted with Prescrl Cyst in n Adult Tkyuki Toyong 1), Hiromitsu Mtsud 1), Ryuichi Miu 1), Yohei Toming 1), Keiji

More information

Analysis of 18 F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

Analysis of 18 F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions ORIGINAL ARTICLE Koren J Intern Med 2013;28:81-88 http://dx.doi.org/10.3904/kjim.2013.28.1.81 Anlysis of F-fluorodeoxyglucose positron emission tomogrphy findings in ptients with pituitry lesions Hnnh

More information

General Microscopic Changes

General Microscopic Changes Generl Microscopic Chnges 2 This chpter covers collection of microscopic chnges tht lck dignostic specificity ut occur in different specific diseses, s will ecome pprent in susequent chpters. Almost ll

More information

Symptomatic Remote Cyst after BCNU Wafer Implantation for Malignant Glioma

Symptomatic Remote Cyst after BCNU Wafer Implantation for Malignant Glioma Cse Report doi: 10.2176/nmc.cr.2017-0218 Neurol Med Chir (Tokyo) 58, 270 276, 2018 Symptomtic Remote Cyst fter BCNU Wfer Implnttion for Mlignnt Gliom Online My 21, 2018 Hideki MATSUMURA, 1 Eiichi ISHIKAWA,

More information

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus Chpter 2 The Dynmics of Vricell-Zoster Virus Epithelil Kertitis in Herpes Zoster Ophthlmicus The morphology of n individul VZV lesion reflects sequence of events triggered y the virus impct on cornel epithelil

More information

Fundamentals of Spine MRI and Essential Protocols

Fundamentals of Spine MRI and Essential Protocols Fundmentls of Spine MRI nd Essentil Protocols A. C. Dougls-Akinwnde, MD Octoer 13, 2009 Fundmentls of Spine MRI Lerning Ojectives: 1. List the essentil sequences for Spine MRI exmintion 2. Discuss the

More information

Ambiguity in the Dural Tail Sign on MRI

Ambiguity in the Dural Tail Sign on MRI SNI: Unique Cse Oservtions OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Ather Enm, M.D., Ag Khn University, Krchi, Sindh, Pkistn Cse Report Amiguity in the Durl

More information

Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer

Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer CASE REPORT Loclized IgG4-relted Cholecystitis Mimicking Gllldder Cncer Tdhis Inoue 1, Fumihiro Okumur 1, Tkshi Mizushim 1, Hirotd Nishie 1, Hiroysu Iwski 1, Kiki Ane 1, Tknori Ozeki 1, Kent Kchi 1, Shigeki

More information

Thallium-201 chloride scintigraphy in soft tissue tumors

Thallium-201 chloride scintigraphy in soft tissue tumors 136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment

More information

Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy

Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy Cse Report doi: 10.5146/tjpth.2017.01411 Concomitnt Introculr Retinoblstom nd Choroidl Hemngiom in 1-Yer-Old oy Ycoub A. Yousef 1, Mys Al-Hussini 2, Freed H. rkt 2, Al Sleh 3, Mon Mohmmd 1, Rsh Deebjh

More information

Findings Regarding an Intracranial Hemorrhage on the Phase Image of a Susceptibility-Weighted Image (SWI), According to the Stage, Location, and Size

Findings Regarding an Intracranial Hemorrhage on the Phase Image of a Susceptibility-Weighted Image (SWI), According to the Stage, Location, and Size pissn 2384-1095 eissn 2384-1109 imri 2015;19:107-113 http://dx.doi.org/10.13104/imri.2015.19.2.107 Findings Regrding n Intrcrnil Hemorrhge on the Phse Imge of Susceptiility-Weighted Imge (SWI), According

More information

Surgical Neurology International

Surgical Neurology International Surgicl Neurology Interntionl OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Jmes I. Ausmn, MD, PhD University of Cliforni, Los Angeles, CA, USA Originl Article

More information

Case Report Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor

Case Report Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor Cse Reports in Medicine Volume 2013, Article ID 235698, 5 pges http://dx.doi.org/10.1155/2013/235698 Cse Report Surgicl Resection of Leiomyosrcom of the Inferior Ven Cv Mimicking Heptic Tumor Junji Ued,

More information

The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report

The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report Hiroshim J. Med. Sci. Vol. 65, No. 1, 13~17, Mrch, 2016 HIJM 65 3 13 The Selective Arteril Clcium Injection Test is Vlid Dignostic Method for Invisile Gstrinom with Duodenl Ulcer Stenosis: A Cse Report

More information

Case report. Primary squamous cell carcinoma of the stomach

Case report. Primary squamous cell carcinoma of the stomach 136 Gstric Cncer (1999) 2: 136 141 S. Mrushi et l.: Primry squmous cell crcinom of the stomch 1999 y Interntionl nd Jpnese Gstric Cncer Associtions Cse report Primry squmous cell crcinom of the stomch

More information

A Vital Role of Magnetic Resonance Imaging in Pregnancy-Related Neurological Complications

A Vital Role of Magnetic Resonance Imaging in Pregnancy-Related Neurological Complications Originl Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/125 A Vitl Role of Mgnetic Resonnce Imging in Pregnncy-Relted Neurologicl Complictions Prveen Kumr Mgudeeswrn 1, Aucker

More information

Intrachiasmatic craniopharyngioma: Assessment of visual outcome with optical coherence tomography after complete surgical removal

Intrachiasmatic craniopharyngioma: Assessment of visual outcome with optical coherence tomography after complete surgical removal SNI: Unique Cse Observtions OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: S. Ather Enm, M.D., Ph.D., Ag Khn University, Krchi, Sindh, Pkistn Cse Report Intrchismtic

More information

University of Cape Town

University of Cape Town .. I i I II I I The copyright of this thesis vests in the uthor. No quottion from it or informtion derived from it is to be published without full cknowledgement of the source. The thesis is to be used

More information

Calcifying nested stromal-epithelial tumor (CNSET) of the liver

Calcifying nested stromal-epithelial tumor (CNSET) of the liver Cse report (CNSET) of the liver Victor Inole 1, Loredn Betrice Ungurenu *,1, Eugeni Moroșn 1, Cristin Dumitru Lupșcu 1,2 1 Grigore T. Pop University of Medicine nd Phrmcy, Isi, Romni; 2 Deprtment of Surgery,

More information

Hyperplastic dental follicle or peri-follicle fibrosis, is. Hyperplastic Dental Follicle Review of Literature and Report of Two Cases in One Family

Hyperplastic dental follicle or peri-follicle fibrosis, is. Hyperplastic Dental Follicle Review of Literature and Report of Two Cases in One Family Puliction Hyperplstic Dentl Follicle Review of Literture nd Report of Two Cses in One Fmily Chun Xio SUN 1, Crig RIRIE 1, Jeffrey M HENKIN 1 Hyperplstic dentl follicle is n extremely rre lesion. The prctitioner

More information

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report CASE REPORT J. Trnsl. Med. Res 2016;21(3):210-214 DOI: 10.21614/jtmr-21-3-96 Recurrent Gint Phyllodes Tumour in Young Femle: A Cse Report Mhim Koshriy 1, Ashish Shrm 1, Ajy Gehlot 1, Surhi Grg 1, M.C.

More information

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation Lepr Rev (2018) 89, 301 305 CASE REPORT Identicl twins with orderline lepromtous leprosy mimicking extensive lopeci ret: A rre presenttion RUBINA JASSI*, KRISHNA DEB BURMAN**, BHAVYA SWARNKAR** & RADHIKA

More information

Neuroendocrine Carcinoma with an Adenocarcinoma Component on the Ampulla of Vater Causing Acute Pancreatitis: A Case Report

Neuroendocrine Carcinoma with an Adenocarcinoma Component on the Ampulla of Vater Causing Acute Pancreatitis: A Case Report CASE REPORT Neuroendocrine Crcinom with n Adenocrcinom Component on the Ampull of Vter Cusing Acute Pncretitis: A Cse Report Reiko Ymd 1, Kenichiro Nishikw 2, Msshi Kishiwd 3, Hiroyuki Inoue 1, Tkshi Skuno

More information

Surgical Neurology International

Surgical Neurology International Surgicl Neurology Interntionl OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Jmes I. Ausmn, MD, PhD University of Cliforni, Los Angeles, CA, USA Cse Report Chnge

More information

CONCURRENT VASCULOGENESIS AND ANGIOGENESIS IN THE NORMAL HUMAN EMBRYO

CONCURRENT VASCULOGENESIS AND ANGIOGENESIS IN THE NORMAL HUMAN EMBRYO ORIGINAL ARTICLES CONCURRENT VASCULOGENESIS AND ANGIOGENESIS IN THE NORMAL HUMAN EMBRYO Anc Cimpen 1, Johnnes Achench 2, Mrius Ric 1 ABSTRACT Four humn emryos were investigted (5, 7, 7 nd 8 weeks old).

More information

imri 2015;19:

imri 2015;19: pissn 2384-1095 eissn 2384-1109 imri 2015;19:241-247 http://dx.doi.org/10.13104/imri.2015.19.4.241 Pncretic Arteriovenous Mlformtion s n Unusul Cuse of Chronic Gstrointestinl Bleeding in Ptient with Erly

More information

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

Magnetic Resonance Imaging (MRI) in Syringomyelia

Magnetic Resonance Imaging (MRI) in Syringomyelia Act Neurochir (Wien)(1995) 134:93-99 :Act. _ N urochlrurgc 9 Springer-Verlg t995 Printed in Austri Mgnetic Resonnce Imging (MRI) in Syringomyeli H. L. J. Tnghe Deprtment of Rdiodignostics, University Hospitl

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

A large mediastinal benign myoepithelioma effacing the entire hemithorax: case report with literature review

A large mediastinal benign myoepithelioma effacing the entire hemithorax: case report with literature review Hshmi et l. Dignostic Pthology (2015) 10:100 DOI 10.1186/s13000-015-0340-y CASE REPORT A lrge medistinl enign myoepitheliom effcing the entire hemithorx: cse report with literture review Atif Ali Hshmi

More information

BENIGN ulceration along the greater curvature of the pars media of the

BENIGN ulceration along the greater curvature of the pars media of the BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the

More information

Case Report Acute Zonal Occult Outer Retinopathy with Atypical Findings

Case Report Acute Zonal Occult Outer Retinopathy with Atypical Findings Cse Reports in Medicine Volume 24, Article ID 29696, 7 pges http://dx.doi.org/.55/24/29696 Cse Report Acute Zonl Occult Outer Retinopthy with Atypicl Findings Dimitrios Krginnis, Georgios A. Kontdkis,

More information

Successful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases

Successful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases CASE REPORT Successful Dignosis of Thymom y Endoronchil Ultrsound-guided Trnsronchil Needle Aspirtion: A Report of Two Cses Ysushi Yoshid 1, Msto Singyoji 1, Hironori Ashinum 1, Meiji Itkur 1, Toshihiko

More information

Multilocular cystic clear cell renal cell carcinoma imaging with histopathologic correlation

Multilocular cystic clear cell renal cell carcinoma imaging with histopathologic correlation CASE REPORT J. Trnsl. Med. Res 2015;20(4):253-257 Multiloculr cystic cler cell renl cell crcinom imging with histopthologic correltion Emi Mrinel Pred 1,3, Ion Griel Lupescu 1,3, Adrin Dijmrescu 3, Gelu

More information

Intraductal Papillary Mucinous Neoplasm With Extensive Mural Osseous Metaplasia and Calcification

Intraductal Papillary Mucinous Neoplasm With Extensive Mural Osseous Metaplasia and Calcification CASE REPORT Intrductl Ppillry Mucinous Neoplsm With Extensive Murl Osseous Metplsi nd Clcifiction Runjn Chetty 1, Sngeeth N Klimuthu 1, Korosh Khlili 2 Deprtments of Pthology 1 nd Joint Deprtment of Medicl

More information

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul

More information

Primary extramedullary plasmacytoma of the sigmoid colon with perforation: a case report

Primary extramedullary plasmacytoma of the sigmoid colon with perforation: a case report Kitmur et l. Surgicl Cse Reports (2018) 4:28 https://doi.org/10.1186/s40792-018-0437-0 CASE REPORT Open Access Primry extrmedullry plsmcytom of the sigmoid colon with perfortion: cse report Fumims Kitmur

More information

Papillary squamous cell carcinoma of the oral mucosa: immunohistochemical comparison with other carcinomas of oral mucosal origin

Papillary squamous cell carcinoma of the oral mucosa: immunohistochemical comparison with other carcinomas of oral mucosal origin 165 Journl Orl Science, Vol. 43, No. 3, 165-169, 2001 Ppillry orl mucos: immunohistochemicl comprison with or s orl mucosl origin Astrct: Ppillry (PSCC) is poorly descried vrint, nd my e confused with

More information

Pulmonary langerhans cell histiocytosis: Two cases with varied radiologic findings

Pulmonary langerhans cell histiocytosis: Two cases with varied radiologic findings CASE REPORT Est J Med 21(1): 45-49, 2016 Pulmonry lngerhns cell histiocytosis: Two cses with vried rdiologic findings Huly Guntr 1,*, Alpsln Yvuz 2, Bunymin Sertogullrindn 1, Selmi Ekin 1, Selvi Asker

More information

Computed Tomography for Localization of Intra- Abdominally Dislocated Intrauterine Devices

Computed Tomography for Localization of Intra- Abdominally Dislocated Intrauterine Devices Act Rdiologic ISSN: 0284-1851 (Print) 1600-0455 (Online) Journl homepge: https://www.tndfonline.com/loi/ird20 Computed Tomogrphy for Locliztion of Intr- Adominlly Dislocted Intruterine Devices Esjörn Hederström,

More information

Case Report INTRODUCTION CASE REPORT. pissn eissn X

Case Report INTRODUCTION CASE REPORT. pissn eissn X pissn 2287-2728 eissn 2287-285X Cse Report Clinicl nd Moleculr Heptology 2018;24:424-429 Complete cure of dvnced heptocellulr crcinom with right drenl glnd metstsis nd portl vein thrombosis by multiple

More information

A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy

A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy Shinozki et l. BMC Cncer (2018) 18:620 https://doi.org/10.1186/s12885-018-4549-5 CASE REPORT A cse of pulmonry denocrcinom showing rpid progression of peritonel dissemintion fter immune checkpoint inhiitor

More information

HISTORY. Surgical Neurology International 2015, 6:174.

HISTORY. Surgical Neurology International 2015, 6:174. Surgicl Neurology Interntionl OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Jmes I. Ausmn, MD, PhD University of Cliforni, Los Angeles, CA, USA Cse Report Intrcrnil

More information

CT and MRI appearances of cystic lesions in the suprahyoid neck: a pictorial review

CT and MRI appearances of cystic lesions in the suprahyoid neck: a pictorial review Dentomxillofcil Rdiology (2007) 36, 1 9 q 2007 The British Institute of Rdiology http://dmfr.irjournls.org REVIEW CT nd MRI ppernces of cystic lesions in the suprhyoid neck: pictoril review EK Woo*,1 nd

More information

Copy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2

Copy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2 Copy Numer Copy Numer Copy Numer Copy Numer DIPG38 DIPG49 ID2 MYCN ID2 MYCN c DIPG01 d DIPG29 ID2 MYCN ID2 MYCN e STNG2 f MYCN DIPG01 Chr. 2 DIPG29 Chr. 1 MYCN DDX1 Chr. 2 ID2 KIDINS220 MBOAT2 ID2 Supplementry

More information

Giant insulinoma: report of a case and review of published reports

Giant insulinoma: report of a case and review of published reports Ued et l. Surgicl Cse Reports (2016) 2:136 DOI 10.1186/s40792-016-0265-z CASE REPORT Gint insulinom: report of cse nd review of pulished reports Open Access Kzumitsu Ued *, Tetsuro Tir, Hiroyuki Hkod,

More information

A rare case of a spontaneously ruptured secondary hepatic malignant lymphoma

A rare case of a spontaneously ruptured secondary hepatic malignant lymphoma Oshit et l. Surgicl Cse Reports (2018) 4:44 https://doi.org/10.1186/s40792-018-0451-2 CASE REPORT Open Access A rre cse of spontneously ruptured secondry heptic mlignnt lymphom Ko Oshit 1, Toshiyuki Itmoto

More information

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel Met nd Food Sfety Needle-Free Injection Enhncement of Beef Strip Loins with Phosphte nd Slt Hs Potentil to Improve Yield, Tenderness, nd Juiciness ut Hrm Texture nd Flvor B.A. Crow, M.E. Dikemn, L.C. Hollis,

More information

Rare case of a rapidly enlarging symptomatic arachnoid cyst of the posterior fossa in an infant: A case report and review of the literature

Rare case of a rapidly enlarging symptomatic arachnoid cyst of the posterior fossa in an infant: A case report and review of the literature SNI: Peditric Neurosurgery OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Sndi Lm, MD University of Chicgo Medicl Center, Chicgo, IL, USA Cse Report Rre cse of

More information

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION 27 June 1964 Bmnly MEDICAL JOURNAL L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION x 1,638.) FIG. 2.-Foci of sme tumour s in Fig. 1 contining vible tumour cells with scnty cytoplsm, reltively

More information

The dynamics of diagnosis of salivary gland tumours: histopathology matters

The dynamics of diagnosis of salivary gland tumours: histopathology matters Interntionl Journl of Reserch in Medicl Sciences Venugopl M et l. Int J Res Med Sci. 2016 Jun;4(6):1855-1861 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Reserch Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161442

More information

Check your understanding 3

Check your understanding 3 1 Wht is the difference etween pssive trnsport nd ctive trnsport? Pssive trnsport is the movement of prticles not requiring energy. Movement of prticles in ctive trnsport uses energy. 2 A gs tp in the

More information

Postinfective physeal bars MRI features and choice of management

Postinfective physeal bars MRI features and choice of management Postinfective physel rs MRI fetures nd choice of mngement Murry Hyes, MB ChB Svvs Andronikou, MB BCh, FC Rd, FRCR, PhD Crey Mckenzie, MB ChB, FCRd Jco du Plessis, MB ChB Reen George, MB BS, MMed Rd Slomine

More information

Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible

Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible Interntionl Journl of Orl Science (2013) 5, 115 119 ß 2013 WCSS. All s reserved 1674-2818/13 www.nture.com/ijos CASE REPORT Cler-cell vrint of clcifying epithelil odontogenic tumor (Pindorg tumor) in the

More information

Sertoli-Leydig Cell Tumor of the Ovary in a Young Female: A Case Report and Literature Review

Sertoli-Leydig Cell Tumor of the Ovary in a Young Female: A Case Report and Literature Review Cse Report Sertoli-Leydig Cell Tumor of the Ovry in Young Femle: A Cse Report nd Literture Review Mdn M. Gupt, Nndini U. Bhri, Rthod Ketn Deprtment of Rdiodignosis nd Imging, Gurugovind Singh Hospitl,

More information

Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia

Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia Mgn Reson Med Sci 2017; 16; 61 65 doi:10.2463/mrms.mp.2016-0039 Pulished Online: July 12, 2016 MAJOR PAPER Gd-sed Contrst Enhncement of the Perivsculr Spces in the Bsl Gngli Shinji Ngnw *, Toshiki Nkne,

More information

Esophageal carcinoma is the eighth most common cancer

Esophageal carcinoma is the eighth most common cancer ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION TM TM tip link horizontl top connectors 1 leucine-rich (21 %) otoncorin-like 1809 ntigenic peptides B D signl peptide hydrophoic segment proline/threonine-rich (79 %) Supplementry Figure 1. () The outer

More information

Prosthetic Valve Dysfunction 35 Years after Mitral Valve Replacement with a Starr-Edwards Caged-disc Valve

Prosthetic Valve Dysfunction 35 Years after Mitral Valve Replacement with a Starr-Edwards Caged-disc Valve CASE REPORT Prosthetic Vlve Dysfunction 35 Yers fter Mitrl Vlve Replcement with Strr-Edwrds Cged-disc Vlve Tetsuro Yokokw 1, Tkhiro Ohr 1, Seiji Tkshio 1, Mri Skmoto 1,YukoWd 1, Kenji Nkmur 1, Hiroyuki

More information

Mantle Cell Lymphoma with Atypical Radiologic Presentation: Case Report

Mantle Cell Lymphoma with Atypical Radiologic Presentation: Case Report Mntle Cell Lymphom with Atypicl Rdiologic Presenttion: Cse Report Linfom de céluls del mnto con presentción rdiológic típic: Presentción de cso Key words (MeSH) Lymphom, mntle-cell Lyphom Tomogrphy, X-ry

More information

HIROATSU NAKASHIMA, MASAHIRO YOSHIDA & KENTARO MIYAMOTO. Department of Orthopedic Surgery, Aichi Hospital, Aichi Cancer Center, Okazaki, Japan

HIROATSU NAKASHIMA, MASAHIRO YOSHIDA & KENTARO MIYAMOTO. Department of Orthopedic Surgery, Aichi Hospital, Aichi Cancer Center, Okazaki, Japan Upsl Journl of Medicl Sciences. 2012; 117: 460 464 CASE REPORT Antomicl reconstruction of the ptellr tendon using the fsci lt ttched to the ilic one following resection for soft tissue srcom: A cse report

More information

Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features

Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features The Koren Journl of Pthology 2014; 48: 201-208 ORIGINAL ARTICLE Clssic Ppillry Thyroid Crcinom with Tll Cell Fetures nd Tll Cell Vrint Hve Similr Clinicopthologic Fetures Woo Jin Oh 1 Young Sub Lee 1 Uiju

More information

MRI of Intraspinal Cysticercosis 1

MRI of Intraspinal Cysticercosis 1 Jou rn l of the Koren Rdiologicl Society, 1995 ; 32( 1) : 33-37 MRI of Intrspinl Cysticercosis 1 Seung Cheol Kim, M.D., Kee-Hyun Chng, M.D., Moon Hee Hn M.D., Gi Seok Hn, M.D., HeeYoung Hwng, M.D.2 Purpose

More information

Breast carcinomas: why are they missed?

Breast carcinomas: why are they missed? O r i g i n l A r t i c l e Singpore Med J 2006; 47(10) : 851 Brest crcinoms: why re they missed? Muttrk M, Pojchmrnwiputh S, Chiwun B ABSTRACT Introduction: Mmmogrphy hs proven to e n effective modlity

More information

Skull fracture vs. accessory sutures: how can we tell the difference?

Skull fracture vs. accessory sutures: how can we tell the difference? Emerg Rdiol (2010) 17:413 418 DOI 10.1007/s10140-010-0877-8 PICTORIAL ESSAY Skull frcture vs. ccessory sutures: how cn we tell the difference? Thoms Snchez & Deorh Stewrt & Mtthew Wlvick & Leonrd Swischuk

More information

Cardiovascular magnetic resonance imaging is becoming a routine diagnostic technique.

Cardiovascular magnetic resonance imaging is becoming a routine diagnostic technique. Crdic mgnetic resonnce imging Crdiovsculr mgnetic resonnce imging is ecoming routine dignostic technique. BRUCE S SPOTTISWOODE, PhD MRC/UCT Medicl Imging Reserch Unit, University of Cpe Town, nd Division

More information

Original Research. Oral mucocutaneous lesions - Histopathological and immunofluorescence study Rameshkumar A et al

Original Research. Oral mucocutaneous lesions - Histopathological and immunofluorescence study Rameshkumar A et al Received: 18 th Septemer 2014 Accepted: 20 th Decemer 2014 Conflicts of Interest: None Source of Support: Nil Originl Reserch Orl Mucocutneous Lesions A Comprtive Clinicopthologicl nd Immunofluorescence

More information

Adnexal Tumors of Skin: An Experience at a Tertiary Care Center at Delhi

Adnexal Tumors of Skin: An Experience at a Tertiary Care Center at Delhi [Downloded free from http://www.mhsr.org] Originl Article Adnexl Tumors of Skin: An Experience t Tertiry Cre Center t Delhi Pujni M, Mdn GB 1, Jirjpuri ZS 2, Jetley S 2, Hssn MJ 2, Khn S 2 Deprtment of

More information

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma doi: 10.2169/internlmedicine.0737-18 Intern Med 57: 3249-3254, 2018 http://internmed.jp CASE REPORT Methotrexte-ssocited Lymphoprolifertive Disorder of the Stomch Presumed to Be Mucos-ssocited Lymphoid

More information

Findings in spontaneous intramural intestinal hematoma imaging

Findings in spontaneous intramural intestinal hematoma imaging Brief report Findings in spontneous intrmurl intestinl hemtom imging F. Mirs Azcón, A. Mrtínez Mrtínez, A. Sntigo Chinchill*, A. Medin Benítez, E. Ochndo Pulido nd M.A. Pérez Rosillo Imging deprtment,

More information

Lucas Ezequiel Serrano Sponton, Ali Ayyad, Eleftherios Archavlis, Florian Alexander Ringel

Lucas Ezequiel Serrano Sponton, Ali Ayyad, Eleftherios Archavlis, Florian Alexander Ringel SNI: Unique Cse Oservtions OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Editor: Ather Enm, M.D., Ag Khn University, Krchi, Sindh, Pkistn Cse Report Unique cse of trigeminl

More information

An autopsy case of rapid progressive atypical carcinoid of the lung discovered with multiple nodular shadows

An autopsy case of rapid progressive atypical carcinoid of the lung discovered with multiple nodular shadows 142 CASE REPORT An utopsy cse of rpid progressive typicl crcinoid of the lung discovered with multiple nodulr shdows Yoshio Okno*, Mmi Inym*, Nouo Htkeym*, Hiroyuki Hino*, Yoshito Iwhr*, Tokuji Motoki*,

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

Neuroradiology and headaches

Neuroradiology and headaches J Hedche Pin (2006) 7:422 432 DOI 10.1007/s10194-006-0347-6 TUTORIAL Andre Romno Vlentin Ciprini Alessndro Bozzo Neurordiology nd hedches Received: 25 Octoer 2006 Accepted in revised form: 6 Novemer 2006

More information

CASE REPORT. Abstract. Introduction. Case Report

CASE REPORT. Abstract. Introduction. Case Report CASE REPORT Pulmonry Tumor Thromotic Microngiopthy Cused y Urothelil Crcinom Expressing Vsculr Endothelil Growth Fctor, Pltelet-derived Growth Fctor, nd Osteopontin Ysushi Wkyshi 1, Mi Iwy 2, Myo Akit

More information

Invasive Pneumococcal Disease Quarterly Report July September 2018

Invasive Pneumococcal Disease Quarterly Report July September 2018 Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.

More information

A Case of Intraductal Papillary Mucinous Carcinoma in the Head of the Pancreas Associated With Absence of the Duct of Wirsung

A Case of Intraductal Papillary Mucinous Carcinoma in the Head of the Pancreas Associated With Absence of the Duct of Wirsung CASE REPORT A Cse of Intrductl Ppillry Mucinous Crcinom in the Hed of the Pncres Associted With Asence of the Duct of Wirsung Ismu Mkino, Tkhis Ymguchi, Mitsuyoshi Okzki, Tomohru Miyshit, Hidehiro Tjim,

More information

Jie Wu 1, Wentao Fang 2, Gang Chen 1. Introduction

Jie Wu 1, Wentao Fang 2, Gang Chen 1. Introduction Review Article The enlightenments from ITMIG Consensus on WHO histologicl clssifiction of thymom nd thymic crcinom: refined definitions, histologicl criteri, nd reporting Jie Wu 1, Wento Fng 2, Gng Chen

More information

Magnetic resonance imaging of solid urethral and peri-urethral lesions

Magnetic resonance imaging of solid urethral and peri-urethral lesions Insights Imging (2013) 4:461 469 DOI 10.1007/s13244-013-0259-3 PICTORIAL REVIEW Mgnetic resonnce imging of solid urethrl nd peri-urethrl lesions Andrew Del Gizo & Alvin C. Silv & Dor M. Lm-Himlin & Brin

More information

Granular cell tumors: a report of six cases

Granular cell tumors: a report of six cases Aoym et l. World Journl of Surgicl Oncology 2012, 10:204 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Grnulr cell tumors: report of six cses Kei Aoym *, Tkko Kmio, Azus Hirno, Akiyoshi Seshimo nd Shingo

More information

Histometry of thyroids containing few and multiple

Histometry of thyroids containing few and multiple J Clin Pthol 1986;39:483-488 Histometry of thyroids contining few nd multiple nodules M AL-MOUSSA, J SWANSON BECK From the Deprtment ofpthology, The University ofdundee, Ninewells Hospitl nd Medicl School,

More information

The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel

The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel Gut, 1971, 12, 11-15 The effects of diversion of intestinl contents on the progress of Crohn's disese of the lrge owel J. H. BURMAN, H. THOMPSON, W. T. COOKE, AND J. ALEXANDER WILLIAMS From the Nutritionl

More information

Radiological appearances of gynaecological emergencies

Radiological appearances of gynaecological emergencies Insights Imging (2012) 3:265 275 DOI 10.1007/s13244-012-0157-0 PICTORIAL REVIEW Rdiologicl ppernces of gynecologicl emergencies Orn Roche & Nikit Chvn & Joseph Aquilin & Andre Rockll Received: 5 Octoer

More information

8 Liver Hemangioma. 8.1 Introduction. 8.2 Sonography. Valérie Vilgrain and Giuseppe Brancatelli

8 Liver Hemangioma. 8.1 Introduction. 8.2 Sonography. Valérie Vilgrain and Giuseppe Brancatelli Liver Hemngiom 101 8 Liver Hemngiom Vlérie Vilgrin nd Giuseppe Brnctelli CONTENTS 8.1 Introduction 101 8.2 Sonogrphy 101 8.3 Computed Tomogrphy 102 8.4 Mgnetic Resonnce 104 8.5 Scintigrphy 107 8.6 Percutneous

More information

Pancreatic Adenocarcinoma Presenting as Acute Large Bowel Obstruction: Case Report

Pancreatic Adenocarcinoma Presenting as Acute Large Bowel Obstruction: Case Report IMAGES IN CLINICAL MEDICINE Surg. Gstroenterol. Oncol. 2018;23(3):204-208 DOI: 10.21614/sgo-23-3-204 Pncretic Adenocrcinom Presenting s Acute Lrge Bowel Ostruction: Cse Report Inês Cmpos Gil 1, Din Prente

More information

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T- lymphocytes

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T- lymphocytes Supporting Online Mteril for Heprnse promotes tumor infiltrtion nd ntitumor ctivity of -redirected T- lymphocytes IgnzioCrun, Brr Svoldo, VlentinHoyos, Gerrit Weer, Ho Liu, Eugene S. Kim, Michel M. Ittmnn,

More information

Colonoscopic decompression of childhood sigmoid and cecal volvulus

Colonoscopic decompression of childhood sigmoid and cecal volvulus CASE REPORT Colonoscopic decompression of childhood sigmoid nd cecl volvulus Irj Shhrmin 1, Ali Bzi 1,2, Dnil Edti 3, Krim Rostmi 3, Mojt Delrmns 1,2 1 Peditric Digestive nd Heptic Reserch Center, Zol

More information

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION DOI: 10.1038/nc2824 Hcn4 Tx5 Mlc2 c Hcn4- ISH d Tx5- ISH e Mlc2-ISH Hcn4-ISH f e Tx5-ISH f -ISH Figure S1 Section in situ hyridistion nlysis of crescent stge mouse emryos (E7.5). () More nterior section

More information

Factors Affecting Concordance between Radiological and Histological Findings in Invasive Lobular Carcinoma Experience from a National Cancer Centre

Factors Affecting Concordance between Radiological and Histological Findings in Invasive Lobular Carcinoma Experience from a National Cancer Centre Originl Article DOI: 10.1159/000455066 Published online: Februry 7, 2017 Fctors Affecting Concordnce between Rdiologicl nd Histologicl Findings in Invsive Lobulr Crcinom Experience from Ntionl Cncer Centre

More information

Visual Cortex in Humans

Visual Cortex in Humans Visul Cortex in Humns 251 Visul Cortex in Humns B A Wndell, S O Dumoulin, nd A A Brewer, Stnford University, Stnford, CA, USA ã 2009 Elsevier Ltd. All rights reserved. Humn visul cortex comprises 4 6 illion

More information

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer Curr Oncol, Vol. 21, pp. e394-399; doi: http://dx.doi.org/10.3747/co.21.1768 CLINICAL MANIFESTATIONS IN AFP PRODUCING GASTRIC CANCER ORIGINAL ARTICLE Clinicl mnifesttions in ptients with lph-fetoprotein

More information

Chapter. Imaging of SARS in North America. Introduction. Clinical Manifestations of SARS in North America

Chapter. Imaging of SARS in North America. Introduction. Clinical Manifestations of SARS in North America content Chpter 13 Nestor L. Müller, Hrry Shulmn Introduction Clinicl Mnifesttions of SARS in North Americ Rdiogrphic Mnifesttions of SARS in North Americ High Resolution CT Findings of SARS in North Americ

More information

Indirect magnetic resonance arthrography of the shoulder; a reliable diagnostic tool for investigation of suspected labral pathology

Indirect magnetic resonance arthrography of the shoulder; a reliable diagnostic tool for investigation of suspected labral pathology Skeletl Rdiol (2013) 42:1225 1233 DOI 10.1007/s00256-013-1644-1 SCIENTIFIC ARTICLE Indirect mgnetic resonnce rthrogrphy of the shoulder; relile dignostic tool for investigtion of suspected lrl pthology

More information

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide Agilent G6825AA MssHunter Pthwys to PCDL Softwre Quick Strt Guide Wht is Agilent Pthwys to PCDL? Fetures of Pthwys to PCDL Agilent MssHunter Pthwys to PCDL converter is stnd-lone softwre designed to fcilitte

More information

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms

More information

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus 2013 67 1 5560 Severe Gummy Smile with Clss II Mlocclusion Treted with LeFort I Osteotomy Comined with Horseshoe Osteotomy nd Introrl Verticl Rmus Osteotomy * 56 Shimo et l. Act Med. Okym Vol. 67, No.

More information