* I have no disclosures or any

Size: px
Start display at page:

Download "* I have no disclosures or any"

Transcription

1 Howard Rosenthal, M.D. Associate Professor of Orthopedic Surgery University of Kansas Sarcoma Center I have no disclosures or any conflicts related to the content of this presentation. Objectives 1. Describe malignant and benign bone and soft tissue tumors. 2. Analyze treatment options for the patient with a musculoskeletal neoplasm. 1

2 Malignant Bone and Soft Tissue Tumors Neoplastic growths arising from the mesenchymal system (mesoderm) In contrast to carcinoma derived from ectoderm and endoderm Termed Sarcoma (Greek fleshy, or fish flesh) Soft Tissue Sarcoma 40 subtypes Bone Sarcoma 20 subtypes All together, accounting for 1% of all cancers May occur in any part of body Occurs in all age ranges Specific types of tumor occur in specific age ranges No specific risk factors or predisposing features Exceptions include: NF, Li Fraumeni s, Gardner s ) Certain chemical exposures (agent orange) No specific serum markers, signs or symptoms Malignant Bone Tumors 6 % of all childhood malignancies Annual U.S. Incidence 8.7 per million Approx children/year Most common osteosarcoma, Ewing s Sarcoma Carcinomas Annual Incidence Overall 4697 per million Lung 610 per million Breast 633 per million 2

3 Sarcomas are derived from the primitive pluripotential mesenchymal cells These pluripotential mesenchymal stem cells: Bone Cartilage Fat Blood Vessels Nerves Fibrous Tissue Soft tissue and bone viscera (gastrointestinal, genitourinary, and gynecologic organs) nonvisceral soft tissues (muscle, tendon, adipose, pleura, and connective tissue) By differentiation (usually with IHC staining) adipocytic tumors fibroblastic/myofibroblastic tumors fibrohistiocytic tumors smooth muscle tumors pericytic (perivascular) tumors primitive neuroectodermal tumors (PNETs) skeletal muscle tumors vascular tumors osseous tumors tumors of uncertain differentiation 3

4 Telangiectatic OGS Small Cell OGS Osteoblastic Chondroblastic Fibroblastic Defined and described based on the mature tissue that they resemble most. (Pattern of Differentiation) Lipomatous tumor = liposarcoma Fibrous tumor fibrosarcoma BioMolecular Markers are redefining the definition of these cancers MDM2 positive fat cell is liposarcoma EWS round cell is Ewing s Sarcoma Initially starting as a chance mutation coding for specific sarcoma, in given environment Clonal growth in centripetal spherical fashion Pushing aside of normal tissues to form pseudocapsule (which is laden with malignant cells) Enzymatic degradation of BM, vascular walls, followed by hematogenous spread to other organs, most specifically lungs. Both local and distant destruction of adjacent tissues until demise of host. 4

5 Normal Muscle (Tissue) Pseudocapsule Tumor Reactive Zone or Pseudocapsule Tumor Compressing Muscle and Infiltrating between Muscle Fibers 5

6 Local growth obeys fascial borders and compartments Fascial borders are good biological barriers to tumor spread Extent of tumor growth defines stage of disease Size, depth, compartmentalization, and grade all define stage Purpose Defines expectation of tumor biology Determines treatment plans Determines prognosis Enables results of treatments among many patients to be compared and evaluated Delineates extent of local and disseminated disease Based on specific cancer type (sarcoma staging versus carcinoma staging) History Length of time mass has been present Rate of growth Pain, (with exercise, at rest, nocturnal, radiating) Ecchymosis, trauma, injury, N/T/W Physical Examination Size Mobility Location, depth, juxtaposition to other structures Texture 6

7 Radiographic evaluation Plain Films CT Scan (w/wo contrast) MRI Scan (with gadolinium) Nuclear Medicine Studies (Bone Scan, PET Scan) MRA, Angiography, U/S, Thallium (less used now) Staging Studies Biopsy CT CAP 1. Where is the tumor and what is rate of growth? 2. What is tumor doing to surrounding tissues? 3. What are surrounding tissues doing to tumor? 4. What is the matrix or identifiable features of the tumor as determined by radiographic and PE? 7

8 8

9 9

10 Geographic Lesion, diaphyseal, without Matrix, without periosteal reaction, slighty thickened cortices 10

11 Geographic, epiphyseal, without matrix, cortical disruption, but with some increased reactive bone margins - GCT Metaphyseal, expansile, fluid levels cortical disruption ABC! Soft Tissue Sarcomas (Biological Behavior) Tumors that are typically High Grade Round Cell Liposarcoma Intramuscular Leiomyosarcoma Rhabdomyosarcoma Angiosarcoma ES Ewing s Sarcoma ES Osteosarcoma Synovial Sarcoma 11

12 Soft Tissue Sarcomas (Biological Behavior) Tumors that are typically Low Grade Well Differentiated Liposarcoma DermatoFibroSarcoma Protuberans Cutaneous Leiomyosarcoma Desmoid Retroperitoneal Liposarcoma Retroperitoneal Liposarcoma 12

13 13

14 Myxofibrosarcoma of Biceps 14

15 High Grade Liposarcoma with pseudocapsule 15

16 16

17 17

18 18

19 Any soft tissue mass > 5 cm. laying deep the the limiting fascia must raise concern for STS Any soft tissue mass in a child Hematomas have to occur for a reason Lipomas feel and behave like lipomas When you hear hoof beats, look for horses not zebras All zoos have zebras (none have horses) 19

20 No Pain Slowly enlarging Any part of body Any age Any texture No risk factors Not hereditary 20

21 None 21

22 22

23 23

24 24

Introduction to Musculoskeletal Tumors. James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon

Introduction to Musculoskeletal Tumors. James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon Introduction to Musculoskeletal Tumors James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon www.tumorsurgery.org Definitions Primary Bone / Soft tissue tumors Mesenchymally derived tumors (Mesodermal)

More information

Soft Tissue Sarcomas: Questions and Answers

Soft Tissue Sarcomas: Questions and Answers Soft Tissue Sarcomas: Questions and Answers 1. What is soft tissue? The term soft tissue refers to tissues that connect, support, or surround other structures and organs of the body. Soft tissue includes

More information

Musculoskeletal Sarcomas

Musculoskeletal Sarcomas Musculoskeletal Sarcomas Robert C. Orth, M.D., Ph.D. Edward B. Singleton Department of Pediatric Radiology Texas Children s Hospital Page 0 xxx00.#####.ppt 9/23/2012 9:01:18 AM No disclosures Page 1 xxx00.#####.ppt

More information

Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON

Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma

More information

5/10. Pathology Soft tissue tumors. Farah Bhani. Mohammed Alorjani

5/10. Pathology Soft tissue tumors. Farah Bhani. Mohammed Alorjani 5/10 Pathology Soft tissue tumors Mohammed Alorjani Farah Bhani Slides are included in this sheet. Objectives: Soft tissue tumors 1. Describe soft tissue tumors. 2. Understand the classification of soft

More information

Update on Sarcomas of the Head and Neck. Kevin Harrington

Update on Sarcomas of the Head and Neck. Kevin Harrington Update on Sarcomas of the Head and Neck Kevin Harrington Overview Classification and incidence of sarcomas Clinical presentation Challenges to treatment Management approaches Prognostic factors Radiation-induced

More information

Rare Cancers. Andrew J. Wagner, MD, PhD Center for Sarcoma and Bone Oncology Dana-Farber Cancer Institute Sarcoma Patient Symposium October 15, 2017

Rare Cancers. Andrew J. Wagner, MD, PhD Center for Sarcoma and Bone Oncology Dana-Farber Cancer Institute Sarcoma Patient Symposium October 15, 2017 Rare Cancers Andrew J. Wagner, MD, PhD Center for Sarcoma and Bone Oncology Dana-Farber Cancer Institute Sarcoma Patient Symposium October 15, 2017 Why should we care about Rare Cancers? Raise your hand

More information

Neoplasia literally means "new growth.

Neoplasia literally means new growth. NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the

More information

Q&A. Fabulous Prizes. Collecting Cancer Data: Bone and Soft Tissue 1/10/113. NAACCR Webinar Series

Q&A. Fabulous Prizes. Collecting Cancer Data: Bone and Soft Tissue 1/10/113. NAACCR Webinar Series Collecting Cancer Data Bone & Soft Tissue NAACCR 2012 2013 Webinar Series Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this

More information

IAEA Pediatric Radiation Oncology Training Dr Laskar Version 1 June SOFT TISSUE SARCOMA (Non Rhabdomyosarcoma)

IAEA Pediatric Radiation Oncology Training Dr Laskar Version 1 June SOFT TISSUE SARCOMA (Non Rhabdomyosarcoma) SOFT TISSUE SARCOMA (Non Rhabdomyosarcoma) Soft Tissue structures Fat, Muscles, Fibrous tissue, Blood vessels, Supporting cells of peripheral nervous system Soft Tissue Sarcomas:- embryologically arise

More information

APMA 2018 Radiology Track Bone Tumors When to say Gulp!

APMA 2018 Radiology Track Bone Tumors When to say Gulp! APMA 2018 Radiology Track Bone Tumors When to say Gulp! DANIEL P. EVANS, DPM, FACFAOM Professor, Department of Podiatric Medicine and Radiology Dr. Wm. Scholl College of Podiatric Medicine Conflict of

More information

Malignant Bone Tumours. PathoBasic, Daniel Baumhoer

Malignant Bone Tumours. PathoBasic, Daniel Baumhoer Malignant Bone Tumours PathoBasic, 20.03.18 Daniel Baumhoer FNCLCC Grading The differentiation score is defined as the extent to which a tumor resembles adult mesenchymal tissue (score 1), the extent to

More information

Contents Part I Introduction 1 General Description 2 Natural History: Importance of Size, Site, Histopathology

Contents Part I Introduction 1 General Description 2 Natural History: Importance of Size, Site, Histopathology Contents Part I Introduction 1 General Description... 3 1.1 Introduction... 3 1.2 Incidence and Prevalence... 5 1.3 Predisposing and Genetic Factors... 8 References... 16 2 Natural History: Importance

More information

Épidémiologie des sarcomes en Belgique

Épidémiologie des sarcomes en Belgique 1 Épidémiologie des sarcomes en Belgique Dr. Liesbet Van Eycken 12 es journées annuelles du GSF-GETO Oud Sint-Jan Bruges, 22-24 juin 2016 Overview Introduction Descriptive epidemiology Incidence Age specific

More information

أملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5

أملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5 Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs

More information

DUSTURBANCES OF GROWTH. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa

DUSTURBANCES OF GROWTH. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa DUSTURBANCES OF GROWTH MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa Agnesia: means complete absence of an organ (Kidney). Aplasia: s defined in general as "defective development

More information

Grading of Bone Tumors

Grading of Bone Tumors Grading of Bone Tumors Joon Hyuk Choi, M.D. Department of Pathology College of Medicine, Yeungnam University Introduction to grading system of bone tumor used at Mayo Clinic WHO Histologic Classification

More information

3/27/2017. Disclosure of Relevant Financial Relationships

3/27/2017. Disclosure of Relevant Financial Relationships Ophthalmic Pathology Evening Specialty Conference USCAP 2017 5 th March, 2017 Mukul K. Divatia, MD Assistant Professor Department of Pathology & Genomic Medicine Weill Cornell Medical College Houston Methodist

More information

Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell

Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell counterpart and line of differentiation. Among the

More information

LAC + USC.

LAC + USC. Jeff McDavit,, M.D. LAC + USC mcdavit@usc.edu Clinical History 55 year old male with large, deep, non- tender left thigh mass. Seen at LAC+USC Med Ctr FNA clinic No h/o trauma or radiation Vimentin

More information

Bone Tumors Clues and Cues

Bone Tumors Clues and Cues William Herring, M.D. 2002 Bone Tumors Clues and Cues In Slide Show mode, advance the slides by pressing the spacebar All Photos Retain the Copyright of their Authors Clues by Appearance of Lesion Patterns

More information

STAGING, BIOPSY AND NATURAL HISTORY OF TUMORS SCOTT D WEINER MD

STAGING, BIOPSY AND NATURAL HISTORY OF TUMORS SCOTT D WEINER MD STAGING, BIOPSY AND NATURAL HISTORY OF TUMORS SCOTT D WEINER MD WHAT DO YOU DO WHEN THIS SHOWS UP IN YOUR OFFICE? besides panicking KEY PRINCIPLE!!! Reactive zone is the edema, neovascularity and inflammation

More information

Molecular pathology in soft tissue tumors. Sylvia Höller Pathologie

Molecular pathology in soft tissue tumors. Sylvia Höller Pathologie Molecular pathology in soft tissue tumors Sylvia Höller Pathologie When do we perform molecular testing? Morphology and IHC are not clearly fitting with an entity some translocations are entity specific

More information

Tumors of Adipose Tissue Tumors Epidemiology Clinical Features. Morphology. Mature Adipocytes Separated by delicate fibrous septa

Tumors of Adipose Tissue Tumors Epidemiology Clinical Features. Morphology. Mature Adipocytes Separated by delicate fibrous septa Tumors of Adipose Tissue Lipoma Liposarcoma Most commonly happens in female The most common soft tissue tumor o Originates from matured Adipocytes Most commonly happes at the 4 th and 5 th decade of life

More information

Case Presentation 主治醫師 : 宋文鑫日期 :

Case Presentation 主治醫師 : 宋文鑫日期 : Case Presentation 主治醫師 : 宋文鑫日期 : 2015-2-28 General Data Name:OOO Chart Number:OOOOOOO Date of Admission:2014 年 08 月 04 日 Age: 33 y/o Sex:female Occupation : 會計 Chief Complaint Palpable soft tissue mass

More information

BONES & JOINTS INFECTION BONE TUMOURS

BONES & JOINTS INFECTION BONE TUMOURS BONES & JOINTS INFECTION BONE TUMOURS IMPORTANT SERIOUS CONSEQUENCE PLEASE DON T MISS!! EARLY DIAGNOSIS & PROPER TREATMENT HOW?? AWARE of THEIR EXISTENCE (Knowledge) PREPARE for THEIR OCCURRENCE A HIGH

More information

Financial disclosures

Financial disclosures An update on immunohistochemical markers in mesenchymal neoplasms By Konstantinos Linos MD, FCAP, FASDP Assistant Professor of Pathology Geisel School of Medicine at Dartmouth Dartmouth-Hitchcock Medical

More information

CODING TUMOUR MORPHOLOGY. Otto Visser

CODING TUMOUR MORPHOLOGY. Otto Visser CODING TUMOUR MORPHOLOGY Otto Visser INTRODUCTION The morphology describes the tissue of the tumour closest to normal tissue Well differentiated tumours are closest to normal Undifferentiated tumours show

More information

Case 8 Soft tissue swelling

Case 8 Soft tissue swelling Case 8 Soft tissue swelling 26-year-old female presented with a swelling on the back of the left knee joint since the last 6 months and chronic pain in the calf and foot since the last 2 months. Pain in

More information

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture Neoplasia part I By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 2 nd Lecture Lecture outline Review of structure & function. Basic definitions. Classification of neoplasms. Morphologic features.

More information

Introduction to Basic Oncology

Introduction to Basic Oncology Introduction to Basic Oncology Cancer Cell AHS 102 Med Term Dr. Susie Turner 1/3/13 General Oncology Study of Tumors Neoplasms/Tumors Abnormal growth of new tissue Are either; Benign or Malignant Onc/o

More information

BIOL 2457 CHAPTER 4 Part 2 SI All connective tissues arise from, an embryonic tissue.

BIOL 2457 CHAPTER 4 Part 2 SI All connective tissues arise from, an embryonic tissue. BIOL 2457 CHAPTER 4 Part 2 SI 1 1. All connective tissues arise from, an embryonic tissue. 2. Describe the vascularity of connective tissues, which are very diverse. 3. Describe the innervation of connective

More information

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques

More information

COPYRIGHT 2004 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED

COPYRIGHT 2004 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED 84 COPYRIGHT 2004 BY THE JOURNAL BONE AND JOINT SURGERY, INCORPORATED Radiographic Evaluation of Pathological Bone Lesions: Current Spectrum of Disease and Approach to Diagnosis BY BENJAMIN G. DOMB, MD,

More information

Mayo Medical Laboratories

Mayo Medical Laboratories Mayo Medical Laboratories Virtual Lectures 2014 MFMER 2016 MFMER slide-1 Virtual Lectures Planning Committee Disclosure Summary As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo

More information

Methoden / Methods inc. ICCC-3 105

Methoden / Methods inc. ICCC-3 105 Methoden / Methods inc. ICCC-3 105 Internationale Klassifikation der Krebserkrankungen bei Kindern (ICCC-3) Zuordnung von ICD-O-3-Codes für Morphologie und Topographie zu diagnostischen Kategorien International

More information

Pathology Mystery and Surprise

Pathology Mystery and Surprise Pathology Mystery and Surprise Tim Smith, MD Director Anatomic Pathology Medical University of South Carolina Disclosures No conflicts to declare Some problem cases Kidney tumor Scalp tumor Bladder tumor

More information

How accurate is MRI in prediction of musculoskeletal tumors -A prospective evaluation

How accurate is MRI in prediction of musculoskeletal tumors -A prospective evaluation Mary Hazarika Bhuyan and R K Bhuyan / International Journal of Biomedical Research 2015; 6(12): 942-946. 942 International Journal of Biomedical Research ISSN: 0976-9633 (Online); 2455-0566 (Print) Journal

More information

MRI XR, CT, NM. Principal Modality (2): Case Report # 2. Date accepted: 15 March 2013

MRI XR, CT, NM. Principal Modality (2): Case Report # 2. Date accepted: 15 March 2013 Radiological Category: Musculoskeletal Principal Modality (1): Principal Modality (2): MRI XR, CT, NM Case Report # 2 Submitted by: Hannah Safia Elamir, D.O. Faculty reviewer: Naga R. Chinapuvvula, M.D.

More information

Essential Dermatopathology. Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center

Essential Dermatopathology. Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center Essential Dermatopathology Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center OBJECTIVES Review clinical, pathologic and molecular aspects of bone and fat tumors

More information

Ultrasound Evaluation of Masses

Ultrasound Evaluation of Masses Ultrasound Evaluation of Masses Jon A. Jacobson, M.D. Professor of Radiology Director, Division of Musculoskeletal Radiology University of Michigan Disclosures: Consultant: Bioclinica Advisory Panel: GE,

More information

MARK D. MURPHEY MD, FACR. Physician-in-Chief, AIRP. Chief, Musculoskeletal Imaging

MARK D. MURPHEY MD, FACR. Physician-in-Chief, AIRP. Chief, Musculoskeletal Imaging ALPHABET SOUP AND CYSTIC LESIONS OF THE BONE MARK D. MURPHEY MD, FACR Physician-in-Chief, AIRP Chief, Musculoskeletal Imaging ALPHABET SOUP AND CYSTIC LESIONS OF THE BONE Giant cell tumor (GCT) Unicameral

More information

Recommendations for Reporting Soft Tissue Sarcomas

Recommendations for Reporting Soft Tissue Sarcomas A J C P / REPORTING SOFT TISSUE SARCOMAS Recommendations for Reporting Soft Tissue Sarcomas Association of Directors of Anatomic and Surgical Pathology Key Words: Sarcoma; Soft tissue tumors Abstract The

More information

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor

More information

The Radiology Assistant : Bone tumor - ill defined osteolytic tumors and tumor-like lesions

The Radiology Assistant : Bone tumor - ill defined osteolytic tumors and tumor-like lesions Bone tumor - ill defined osteolytic tumors and tumor-like lesions Henk Jan van der Woude and Robin Smithuis Radiology department of the Onze Lieve Vrouwe Gasthuis, Amsterdam and the Rijnland hospital,

More information

Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes

Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes Sarcoma Volume 2015, Article ID 740571, 5 pages http://dx.doi.org/10.1155/2015/740571 Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes Hiroshi Kobayashi,

More information

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D.

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D. NEOPLASIA-I CANCER Nam Deuk Kim, Ph.D. 1 2 Tumor in the hieroglyphics of the Edwin Smith papyrus (1,600 B.C., Breasted s translation 1930) 3 War on Cancer (National Cancer Act, 1971) 4 Cancer Acts in Korea

More information

Disclosures. Giant Cell Rich Tumors of Bone. Outline. The osteoclast. Giant cell rich tumors 5/21/11

Disclosures. Giant Cell Rich Tumors of Bone. Outline. The osteoclast. Giant cell rich tumors 5/21/11 Disclosures Giant Cell Rich Tumors of Bone Andrew Horvai, MD, PhD Associate Clinical Professor, Pathology This lecture discusses "off label" uses of a number of pharmaceutical agents. The speaker is describing

More information

Review Course «Musculoskeletal Oncology» October 6, 2011 UNIKLINIK BALGRIST. Imaging of Bone and Soft Tissue. Tumors

Review Course «Musculoskeletal Oncology» October 6, 2011 UNIKLINIK BALGRIST. Imaging of Bone and Soft Tissue. Tumors Imaging of Bone and Soft Tissue Tumors Approach from a radiologist s point of view Florian Buck Radiology Radio- Radio- Oncologist Oncologist Orthopedist Orthopedist Patient Management Oncologist Oncologist

More information

Dr Sneha Shah Tata Memorial Hospital, Mumbai.

Dr Sneha Shah Tata Memorial Hospital, Mumbai. Dr Sneha Shah Tata Memorial Hospital, Mumbai. Topics covered Lymphomas including Burkitts Pediatric solid tumors (non CNS) Musculoskeletal Ewings & osteosarcoma. Neuroblastomas Nasopharyngeal carcinomas

More information

Radio-Pathologic Workup of a Retroperitoneal Abdominal Mass

Radio-Pathologic Workup of a Retroperitoneal Abdominal Mass Radio-Pathologic Workup of a Retroperitoneal Abdominal Mass Joe Carlson Advanced Radiology Clerkship Harvard Medical School Year IV September 12, 2002 84 year old Male Presented to PCP With Abdominal Pain

More information

The Cytology of Soft Tissue Tumours

The Cytology of Soft Tissue Tumours The Cytology of Soft Tissue Tumours Monographs in Clinical Cytology Vol.16 Series Editor Svante R. Orell Kent Town The Cytology of Soft Tissue Tumours Måns Åkerman, Patologisk/Cytologisk Klinik, Lund Henryk

More information

Principles of Surgical Oncology. Winnie Achilles Tierklinik Hollabrunn Lastenstrasse Hollabrunn

Principles of Surgical Oncology. Winnie Achilles Tierklinik Hollabrunn Lastenstrasse Hollabrunn Principles of Surgical Oncology Winnie Achilles Tierklinik Hollabrunn Lastenstrasse 2 2020 Hollabrunn boexi@gmx.de The first surgery provides the best chance for a cure in an animal with a tumor Clinical

More information

Bone, soft tissue and skin tumors. By: Shefaa qa qa

Bone, soft tissue and skin tumors. By: Shefaa qa qa Bone, soft tissue and skin tumors By: Shefaa qa qa Bone tumors Most bone neoplasms develop during the first several decades of life and have a propensity for the long bones of the extremities. The occurrence

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Magn Reson Imaging Clin N Am 12 (2004) 185 189 Index Note: Page numbers of article titles are in boldface type. A Acromioclavicular joint, MR imaging findings concerning, 161 Acromion, types of, 77 79

More information

Ultrasonography. Methods. Brief Description. Indications. Device-related Prerequisites. Technical Requirements. Evaluation Criteria

Ultrasonography. Methods. Brief Description. Indications. Device-related Prerequisites. Technical Requirements. Evaluation Criteria 1 Ultrasonography Brief Description Imaging modality using sound waves Tissue-specific wave reflection. Indications Evaluation of palpable breast nodules Evaluation of clinically occult mammographic findings

More information

I sarcomi dei tessuti molli

I sarcomi dei tessuti molli Novità e sequenze terapeutiche nelle neoplasie ginecologiche, melanoma e tumori rari: I sarcomi dei tessuti molli Giacomo G. Baldi Oncologia Medica Sandro Pitigliani Nuovo Ospedale S.Stefano Azienda USL

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our

More information

GIANT CELL-RICH OSTEOSARCOMA: A CASE REPORT

GIANT CELL-RICH OSTEOSARCOMA: A CASE REPORT Nagoya J. Med. Sci. 59. 151-157, 1996 CASE REPORTS GIANT CELL-RICH OSTEOSARCOMA: A CASE REPORT KEIJI SATO!, SHIGEKI YAMAMURA!, HISASHI IWATA!, HIDESHI SUGIURA 2, NOBUO NAKASHIMA 3 and TETSURO NAGASAKA

More information

Multidisciplinary management of retroperitoneal sarcomas

Multidisciplinary management of retroperitoneal sarcomas Multidisciplinary management of retroperitoneal sarcomas Eric K. Nakakura, MD UCSF Department of Surgery UCSF Comprehensive Cancer Center San Francisco, CA 7 th Annual Clinical Cancer Update North Lake

More information

Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology

Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory

More information

Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden. Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4

Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden. Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4 Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4 Modified April, 2009 Scandinavian Sarcoma Group & Oncologic Center, Lund,

More information

CASE REPORT PLEOMORPHIC LIPOSARCOMA OF PECTORALIS MAJOR MUSCLE IN ELDERLY MAN- CASE REPORT & REVIEW OF LITERATURE.

CASE REPORT PLEOMORPHIC LIPOSARCOMA OF PECTORALIS MAJOR MUSCLE IN ELDERLY MAN- CASE REPORT & REVIEW OF LITERATURE. PLEOMORPHIC LIPOSARCOMA OF PECTORALIS MAJOR MUSCLE IN ELDERLY MAN- CASE REPORT & REVIEW OF LITERATURE. M. Madan 1, K. Nischal 2, Sharan Basavaraj. C. J 3. HOW TO CITE THIS ARTICLE: M. Madan, K. Nischal,

More information

Financial disclosures

Financial disclosures Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchc Geisel School of

More information

Plain Film CT. Principal Modality (2): Case Report # [] Date accepted: 15 March 2014

Plain Film CT. Principal Modality (2): Case Report # [] Date accepted: 15 March 2014 Radiological Category: Musculoskeletal Principal Modality (1): Principal Modality (2): Plain Film CT Case Report # [] Submitted by: Dr. Jason E. Lally, M.D. Faculty reviewer: Dr. Naga Ramesh Chinapuvvula,

More information

Advertisement. Osteochondroma

Advertisement. Osteochondroma Advertisement Osteochondroma An osteochondroma is a benign (noncancerous) tumor that develops during childhood or adolescence. It is an abnormal growth that forms on the surface of a bone near the growth

More information

MRI Of Locally Recurrent Soft Tissue Tumors Of The Musculoskeletal System

MRI Of Locally Recurrent Soft Tissue Tumors Of The Musculoskeletal System ISPUB.COM The Internet Journal of Radiology Volume 5 Number 2 MRI Of Locally Recurrent Soft Tissue Tumors Of The Musculoskeletal System C Costelloe, A Yasko, W Murphy, R Kumar, V Lewis, P Lin, R Stafford,

More information

Mark D. Murphey, MD, FACR

Mark D. Murphey, MD, FACR Fundamental Concepts of Musculoskeletal Neoplasm: CT and MRI Mark D. Murphey, MD, FACR Important Features in Evaluation of Musculoskeletal Masses Differential diagnosis Preoperative assessment and staging

More information

Hsin-Nung Shih M.D. Soft Tissue Tumor

Hsin-Nung Shih M.D. Soft Tissue Tumor Soft Tissue Tumor Hsin-Nung Shih M.D. PROFESSOR DIVISION OF JOINT RECONSTRUCTION DEPARTMENT OF ORTHOPEADIC CHANG GUNG MEMORIAL HOSPITAL CHANG GUNG UNIVERSITY,COLLEGE OF MEDICINE TAIWAN Soft Tissue Tumor

More information

Soluble CD155 As A Biomarker For Malignant Bone And Soft Tissue Tumors

Soluble CD155 As A Biomarker For Malignant Bone And Soft Tissue Tumors Soluble CD155 As A Biomarker For Malignant Bone And Soft Tissue Tumors Mikinobu Goto, MD, Akihiko Matsumine, MD,PhD, Tomoki Nakamura, MD PhD, Takao Matsubara, MD PhD, Kunihiro Asanuma, MD,PhD, Toru Oi,

More information

Case 9087 Retropharyngeal nodular fasciitis

Case 9087 Retropharyngeal nodular fasciitis Case 9087 Retropharyngeal nodular fasciitis Santiago I 1; Cavalheiro F 2; Noruégas MJ 3; Sanches MC3 1 Hospital Infante D. Pedro, Aveiro, Portugal 2 Hospitais da Universidade de Coimbra, Portugal 3 Hospital

More information

UK Musculoskeletal Oncology: Something for All Ages. Lars Wagner, MD Pediatric Hematology/Oncology University of Kentucky

UK Musculoskeletal Oncology: Something for All Ages. Lars Wagner, MD Pediatric Hematology/Oncology University of Kentucky UK Musculoskeletal Oncology: Something for All Ages Lars Wagner, MD Pediatric Hematology/Oncology University of Kentucky Pediatric-Type Sarcomas of Bone and Soft Tissue The incidence of sarcoma continues

More information

Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat version (downloaded 3/23/2017)

Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat version (downloaded 3/23/2017) APPENDIX I. SEER Search criteria and exclusion criteria. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat version 8.3.4 (downloaded 3/23/2017) SEER*Stat Database:

More information

A neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after

A neoplasm is defined as an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a

More information

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques

More information

Bone Tumours - a synopsis. Dr Zena Slim SpR in Histopathology QAH 2009

Bone Tumours - a synopsis. Dr Zena Slim SpR in Histopathology QAH 2009 Bone Tumours - a synopsis Dr Zena Slim SpR in Histopathology QAH 2009 Aims General approach to diagnosis Common entities.and not so common ones. Mini quiz Challenge of bone tumour diagnosis Bone tumours

More information

MSK Interesting Cases. Dr Yap Sheau Huey

MSK Interesting Cases. Dr Yap Sheau Huey MSK Interesting Cases Dr Yap Sheau Huey Case 1: History 41 y.o man, surf skier C/o pain over anterior left 5 th to 8 th ribs. Worse after sport activity. Chest Radiograph US Periostitis and early callus

More information

An Overview of Genital Stromal Tumors

An Overview of Genital Stromal Tumors An Overview of Genital Stromal Tumors By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel School of Medicine

More information

USCAP COMPANION MEETING INTERNATIONAL SOCIETY OF BONE AND SOFT TISSUE PATHOLOGY DENVER, March 2 nd 2008

USCAP COMPANION MEETING INTERNATIONAL SOCIETY OF BONE AND SOFT TISSUE PATHOLOGY DENVER, March 2 nd 2008 1 USCAP COMPANION MEETING INTERNATIONAL SOCIETY OF BONE AND SOFT TISSUE PATHOLOGY DENVER, March 2 nd 2008 THE EVOLUTION OF SOFT TISSUE TUMOUR TAXONOMY: WHAT STILL NEEDS TO BE DONE? Christopher D.M. Fletcher,

More information

Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors

Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors Original Article DOI: 10.21276/APALM.1637 Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors Sridevi. V*., Susruthan Muralitharan., and Thanka. J Dept of Pathology, SriMuthukumaran Medical

More information

Conceptual Evolution of Soft Tissue Tumors Classification

Conceptual Evolution of Soft Tissue Tumors Classification Conceptual Evolution of Soft Tissue Tumors Classification Angelo P. Dei Tos M.D. Departments of Pathology & Oncology Treviso, Italy How WHO classification was reshaped Pathologists and Cytogeneticists

More information

Soft Tissue Sarcoma. Presley Regional Trauma Center Department of Surgery University of Tennessee Health Science Center Memphis, Tennessee

Soft Tissue Sarcoma. Presley Regional Trauma Center Department of Surgery University of Tennessee Health Science Center Memphis, Tennessee Soft Tissue Sarcoma Presley Regional Trauma Center Department of Surgery University of Tennessee Health Science Center Memphis, Tennessee Soft Tissue Sarcoma Collective term for an unusual and diverse

More information

Primary Breast Liposarcoma

Primary Breast Liposarcoma Primary Breast Liposarcoma Bhagyam Nagarajan 1*, GayatriAutkar 1, Keyuri Patel 1, Meghal Sanghvi 1 1. Department of Radiology, Wockhardt Hospital, Mumbai, India * Correspondence: Dr Bhagyam Nagarajan,

More information

Retroperitoneal Sarcomas - A pictorial review

Retroperitoneal Sarcomas - A pictorial review Retroperitoneal Sarcomas - A pictorial review Poster No.: C-1409 Congress: ECR 2013 Type: Educational Exhibit Authors: D. Douraghi-Zadeh, K. L. Shahabuddin, R. H. Thomas, E. Moskovic; London/UK Keywords:

More information

Fun with Fat. General Rules. Case

Fun with Fat. General Rules. Case Fun with Fat General Rules Imaging: location (deep vs. superficial) Superficial lesions are seldom liposarcomas Deep lesions may be benign or malignant Myxoid stroma is common in benign and malignant lesions

More information

Malignant bone tumors. Incidence Myeloma 45% Osteosarcoma 24% Chondrosarcoma 12% Lyphoma 8% Ewing s Sarcoma 7%

Malignant bone tumors. Incidence Myeloma 45% Osteosarcoma 24% Chondrosarcoma 12% Lyphoma 8% Ewing s Sarcoma 7% Malignant bone tumors Incidence Myeloma 45% Osteosarcoma 24% Chondrosarcoma 12% Lyphoma 8% Ewing s Sarcoma 7% Commonest primary bone sarcoma is osteosarcoma X ray Questions to ask 1. Solitary or Multiple

More information

Mesothelioma: diagnostic challenges from a pathological perspective. Naseema Vorajee August 2016

Mesothelioma: diagnostic challenges from a pathological perspective. Naseema Vorajee August 2016 Mesothelioma: diagnostic challenges from a pathological perspective Naseema Vorajee August 2016 Naseema.vorajee@nhls.ac.za Pleural diseases (whether neoplastic, reactive or infective) may have similar

More information

The Completeness of Soft Tissue Sarcoma Data in the National Cancer Data Repository

The Completeness of Soft Tissue Sarcoma Data in the National Cancer Data Repository The Completeness of Soft Tissue Sarcoma Data in the National Cancer Data Repository Tumours diagnosed between 2006 and 2008 West Midlands Cancer Intelligence Unit Completeness of cancer data 2008 Soft

More information

Evening Specialty Conference Bone and Soft Tissue Pathology. Diagnostic pitfalls in bone and soft tissue pathology

Evening Specialty Conference Bone and Soft Tissue Pathology. Diagnostic pitfalls in bone and soft tissue pathology Evening Specialty Conference Bone and Soft Tissue Pathology. Case 1 Elizabeth G Demicco, MD, PhD Mount Sinai Hospital, New York Disclosure of Relevant Financial Relationships USCAP requires that all planners

More information

University Journal of Surgery and Surgical Specialities

University Journal of Surgery and Surgical Specialities University Journal of Surgery and Surgical Specialities Volume 1 Issue 1 2015 EXTRA SKELETAL MESENCHYMAL CHONDROSARCOMA :A CASE REPORT Rajaraman R Subbiah S Navin Naushad Kilpaulk Medical College Abstract:

More information

A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1

A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 1 Animal Health Trust, Newmarket, UK 2 608 Equine and Farm Vets, Rowington, UK Signalment: Horse,

More information

ORIGINAL ARTICLE Histopathological diagnoses in soft tissue tumours: an experience from a tertiary centre in Malaysia

ORIGINAL ARTICLE Histopathological diagnoses in soft tissue tumours: an experience from a tertiary centre in Malaysia Malaysian J Pathol 2017; 39(3) : 209 216 ORIGINAL ARTICLE Histopathological diagnoses in soft tissue tumours: an experience from a tertiary centre in Malaysia Nur Dini JALALUDIN MB Bch BAO, Noraini MOHD

More information

INDEX. in this web service Cambridge University Press

INDEX. in this web service Cambridge University Press actin 14 adamantinoma 202, 290 292, 297 adenocarcinoma 136 adipocytes in hibernoma 149, 150 in lipoblastoma 148 in lipoma 141, 142, 145 in liposarcoma 152 in myelolipoma 151 adrenal gland tumors see myelolipoma

More information

Primary Bone Tumors: Spine Surgery Live -Video Techniques Mobile Spine

Primary Bone Tumors: Spine Surgery Live -Video Techniques Mobile Spine Primary Bone Tumors: Spine Surgery Live -Video Techniques Mobile Spine Christopher Ames MD Professor of Neurosurgery and Orthopedic Surgery Director of Spine Tumor And Deformity Surgery UCSF Department

More information

DOWNLOAD OR READ : TUMORS AND TUMOR LIKE CONDITIONS OF THE LUNG AND PLEURA PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : TUMORS AND TUMOR LIKE CONDITIONS OF THE LUNG AND PLEURA PDF EBOOK EPUB MOBI DOWNLOAD OR READ : TUMORS AND TUMOR LIKE CONDITIONS OF THE LUNG AND PLEURA PDF EBOOK EPUB MOBI Page 1 Page 2 tumors and tumor like conditions of the lung and pleura tumors and tumor like pdf tumors and

More information

ONCOLOGY. Csaba Bödör. Department of Pathology and Experimental Cancer Research november 19., ÁOK, III.

ONCOLOGY. Csaba Bödör. Department of Pathology and Experimental Cancer Research november 19., ÁOK, III. ONCOLOGY Csaba Bödör Department of Pathology and Experimental Cancer Research 2018. november 19., ÁOK, III. bodor.csaba1@med.semmelweis-univ.hu ONCOLOGY Characteristics of Benign and Malignant Neoplasms

More information

Cancer Fundamentals. Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource

Cancer Fundamentals. Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource Cancer Fundamentals Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource Cancer Overview Leading cause of death in US 1.2 million diagnosed each year More common after age

More information

57th Annual HSCP Spring Symposium 4/16/2016

57th Annual HSCP Spring Symposium 4/16/2016 An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no

More information

Imaging Evaluation of Malignant Chest Wall Neoplasms 1

Imaging Evaluation of Malignant Chest Wall Neoplasms 1 This copy is for personal use only. To order printed copies, contact reprints@rsna.org Imaging Evaluation of Malignant Chest Wall Neoplasms 1 1285 CHEST IMAGING Brett W. Carter, MD Marcelo F. Benveniste,

More information

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, 2008 9:30am - 11:30am FACULTY COPY GOAL: Describe the basic morphologic (structural) changes which occur in various pathologic conditions.

More information