Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case.
|
|
- Alyson Osborne
- 6 years ago
- Views:
Transcription
1 ISPUB.COM The Internet Journal of Pathology Volume 10 Number 1 Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case. V Kinnera, R Nandyala, M Yootla, K Mandyam Citation V Kinnera, R Nandyala, M Yootla, K Mandyam. Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case.. The Internet Journal of Pathology Volume 10 Number 1. Abstract Palisaded myofibroblastoma of lymph node is a rare entity and only a few cases have been documented in the literature and atypical palisaded myofibroblastoma is still rare. Till 1989, only 32 cases of palisaded myofibroblastoma or intranodal hemorrhagic spindle cell tumor of lymph node have been reported in the literature. We report a case of 60 year old female who presented with lump in the right inguinal region since fourteen years. Clinically it was considered as tuberculous lymphadenitis. Lymph node biopsy was performed and histopathologically it was diagnosed as atypical palisaded myofibroblastoma of lymph node. INTRODUCTION PATHOLOGICAL FINDINGS Palisaded myofibroblastoma is a benign mesenchymal lymph node tumor characterized by palisaded spindle cells, stellate deposits of collagen(amianthoid fibers) and hemorrhages, first reported simultaneously by Weiss et al[1] and Suster and Rosai[2] in 1989 and described it as a distinctive benign spindle cell tumor, arising exclusively from the lymph nodes. Men are more commonly affected than women with an age predilection between 19 to 67 years, 6th decade being more common age group [1, 2]. Though inguinal area is a common site, in rare cases it was even reported in cervical [3], submandibular [4] and mediastinal lymph nodes. In most of the cases the behavior is completely benign except a single inguinal case which was reported with local recurrence after 9 yrs [5]. MACROSCOPY The lymph node was grey-brown, congested and encapsulated with perinodal adipose tissue measuring 5.0X3.0X2.0 cms and cut-surface was grey-white, solid and multilobulated with focal areas of hemorrhages (Figure.1). Figure 1 Fig.1 Cut- surface of the lymph node - grey-white, solid, multilobulated with focal areas of hemorrhages. CASE REPORT A 60 years old female presented with the history of lump in the right groin for the last fourteen years, which was gradually increasing in size. Initially it was painless and for the past four months it was associated with pain and rapid increase in size. On examination, there was an ovoid, nodular painful and tender lump of 5x3 cms located in the right groin below the inguinal ligament. Skin over the swelling was stretched but there was no infiltration. Preoperatively, other laboratory tests were within normal limits except for mild anemia of normocytic normochromic type. With a clinical the diagnosis of tuberculous lymphadenitis, lymph node biopsy was performed. MICROSCOPY Sections examined from different areas of excised lesional mass revealed the histology of lymph node with welldelineated fibrous encapsulated prominent central lesional component composed of a few reactive follicles at the 1 of 5
2 periphery and mostly replaced by criss-cross, whorly and storiform fasciculi with oval to pleomorphic, vesicular nuclei, a few atypical mitotic figures, repeated nuclear palisades, hyalinized blood vessels with thick collagenous mats (amianthoid fibers) (Figures 2-5), foci of degeneration, edema and lymphoplasmacytic collections. Considering the differential diagnosis of metastatic malignant fibrous histiocytoma, Kaposi s Sarcoma and neurilemmoma, the paraffin blocks were subjected for histochemistry such as vangieson and masson s trichrome and immunohistochemistry such as smooth muscle actin, vimentin, desmin, cytokeratin, factor-viii related antigen, S100 protein, α-1 anti trypsin and chymotrypsin. The collagen stained intensely blue with masson s trichrome and immunohistochemistry revealed positivity for smooth muscle actin and vimentin (Figures 6 and 7) but not for desmin, S-100 protein, factor-viii related antigen and cytokeratin. Basing on these features a diagnosis of atypical palisaded myofibroblastoma of lymph node was made. No primary lesion elsewhere could be seen and the metastatic tumors won t exhibit capsule unlike the primary lesion of lymph node. Figure 2 Fig.2 microphotograph exhibiting well-delineated fibrous encapsulated prominent central lesional component composed of a few reactive follicles at the periphery (H and E, X100). 2 of 5 Figure 3 Fig.3 - microphotograph exhibiting criss-cross, whorly and storiform spindle cell fasciculi (H and E, X200). Figure 4 Fig.4 - microphotograph exhibiting hyalinized blood vessels with thick collagenous mats (amianthoid fibers) (H and E, X 100)
3 Figure 5 Figure 7 Fig.5 - microphotograph exhibiting storiform fasciculi with oval to pleomorphic, vesicular nuclei, tumor giant cells and a few atypical mitotic figures (H and E, X200). Fig.7 - microphotograph exhibiting intense cytoplasmic positivity for vimentin (IHC, X400) DISCUSSION Figure 6 Fig.6 - microphotograph exhibiting intense cytoplasmic positivity for smooth muscle actin (IHC, X400). Palisaded myofibroblastoma of lymph node is extremely rare, with only a few cases being reported in the literature. In 1989, Weiss et al., [1] and Suster and Rosai[2] described simultaneously, the palisaded myofibroblastoma is a distinctive benign spindle cell tumor arising exclusively from the lymph nodes and bearing an unmistakable similarity to a schwannoma. It is also known as intranodal hemorrhagic spindle cell tumor with amianthoid fibers. In fact, so striking is the resemblance that these lesions were originally reported as schwannoma of the lymphnode [6]. Because cells derived from smooth muscle usually contain desmin, the absence of desmin in palisaded myofibroblastoma initially suggested a cell type other than smooth muscle [1-2]. On the other hand, vascular or capsular smooth muscle cells could also give rise to the spindle cells of palisaded myofibroblastoma as evidenced by immunohistochemical positivity for smooth muscle actin, vimentin and myosin [7]. Though most patients present with a solitary, unilateral nodular mass, yet a single case of multicentric intranodal palisaded myofibroblastoma was reported in 1994 by Lioe TF et al [5]. This tumor usually occurs in the inguinal region and rarely in cervical [3] submandibular [4] and mediastinal regions. The predilection of this tumor to occur in the groin was supposed to be increased smooth muscle content in inguinal lymph nodes in contrast to lymph nodes of other areas [1]. Almost all of the cases reported in the literature have behaved in a benign fashion, with no recurrence or metastasis [1-2] except a single case which was reported with local recurrence after 9 years of excision [5]. The possibility of recurrence of the present case reported also 3 of 5
4 was intimated to the concerned for follow-up. CONCLUSION It is important to recognize that this lesion represents a primary benign, mesenchymal lesion which carries good prognosis and not a metastatic sarcoma exhibiting poor prognosis. These tumors are quite well-differentiated and have low levels of mitotic activity in contrast to the present case which is exhibiting atypical nuclear features with the presence of mitotic figures arising difficulty to differentiate from metastatic sarcomas. More over, sarcomas infrequently metastasize to lymph nodes, and when they do so it is usually an expression of disseminated disease and rarely an initial presentation. This case is being reported because of its rarity, clinical, prognostic significance and to avoid misinterpretation as sarcomatous metastasis. References 4 of 5 1. Weiss SW, Gnepp DR, Bratthauer GL. Palisaded myofibroblastoma: a benign mesenchymal tumor of lymph node. Am J Surg Pathol 1989; 13: Suster S, Rosai J. Intranodal hemorrhagic spindle cell tumor with amianthoid fibers: report of six cases of distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi s sarcoma, Am J Surg Pathol 1989; 13: Michal M, Chlumska A, Povysilova V. Intranodal amianthoid myofibroblastoma. Report of six cases: immunohistochemical and electron microscopical study. Pathol Res Pract 1992; 188: Fletcher CD, Stirling RW. Intranodal myofibroblastoma presenting in the submandibular region: evidence of a broader clinical and histological spectrum. Histopathology 1990; 16: Lioe TF, Allen DC, Bell JC. A case of multicentric intranodal palisaded myofibroblastoma. Histopathology1994; 24: Katz D. Neurilemmoma with calcerosiderotic nodules Isr J Med Sci 1974; 10: Tanda F, Massarelli G, Cossu A et al. Primary spindle cell tumor of lymph node with amianthoid fibers: a histological, immunohistochemical and ultrastructural study. Ultrastruct Pathol 1993; 17:
5 Author Information Vijay Sreedhar Babu Kinnera, MD Assistant Professor, Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati Rukmangadha Nandyala Assistant Professor, Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati Mutheeswaraiah Yootla, MS Associate Professor, Department of General Surgery, Sri Venkateswara Institute of Medical Sciences, Tirupati Kumaraswamy Reddy Mandyam, MD Professor & Head, Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati 5 of 5
ISPUB.COM. Salivary duct carcinoma of parotid gland. V Kinnera, R Nandyala, M Yootla, K Mandyam INTRODUCTION CASE REPORT
ISPUB.COM The Internet Journal of Pathology Volume 10 Number 1 V Kinnera, R Nandyala, M Yootla, K Mandyam Citation V Kinnera, R Nandyala, M Yootla, K Mandyam.. The Internet Journal of Pathology. 2008 Volume
More informationDesmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC
R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o
More informationA 25 year old female with a palpable mass in the right lower quadrant of her abdomen
May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and
More informationIN THE NAME OF GOD Dr. Kheirandish Oral and maxillofacial pathology
IN THE NAME OF GOD Dr. Kheirandish Oral and maxillofacial pathology ORAL FOCAL MUCINOSIS Uncommon Tumorlike Cutaneous myxoid cyst Overproduction of hyaluronic acid by firoblasts Young adults Female Gingiva
More informationأملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5
Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs
More informationCASE REPORT Benign epithelioid peripheral nerve sheath tumour resembling schwannoma
Malaysian J Pathol 2014; 36(3) : 217 221 CASE REPORT Benign epithelioid peripheral nerve sheath tumour resembling schwannoma Thejasvi KRISHNAMURTHY MD and SR NIVEDITHA MD, DNB Department of Pathology,
More informationAll authors abide by the Association for Medical Ethics (AME) ethical rules of disclosure.
Longo F, Musumeci G, Parenti R, Vecchio G, Magro G. Atypical cell leiomyoma of the uterus with amianthoid-like fibers: A case report. OA Case Reports 2013 Nov 15;2(14):137. Licensee OA Publishing London
More informationCase 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is:
Case 27 Male 42. Painless, static, well-circumscribed, subcutaneous nodule right lower leg,?lipoma. The best diagnosis is: A. Angiosarcoma B. Haemangiopericytoma C.Myopericytoma D.Myofibroma E. Angioleiomyoma
More informationA case of giant benign localized fibrous tumor of the pleura
Turkish Journal of Cancer Vol.30 / No. 4/2000 A case of giant benign localized fibrous tumor of the pleura ALİ KEMAL UZUNLAR 1, MEHMET YALDIZ 1, İBRAHİM H. ÖZERCAN 2, FAHRİ YILMAZ 1, AKIN E. BALCI 3 1
More informationThe Relevance of Cytologic Atypia in Cutaneous Neural Tumors
The Relevance of Cytologic Atypia in Cutaneous Neural Tumors Recent Findings - New Developments New Problems Zsolt B. Argenyi, M.D. Professor of Pathology & Dermatology Director of Dermatopathology Department
More informationDiplomate of the American Board of Pathology in Anatomic and Clinical Pathology
A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory
More informationSpindle Cell Lesions Of The Breast. Emad Rakha Professor of Breast Pathology and Consultant Pathologist
Spindle Cell Lesions Of The Breast Emad Rakha Professor of Breast Pathology and Consultant Pathologist * SCLs comprise a wide spectrum of diseases, ranging from reactive processes to aggressive malignant
More informationEnterprise Interest Nothing to declare
Enterprise Interest Nothing to declare Diagnoses one would not like to miss in soft tissue pathology early in your career Marta Sbaraglia, MD Department of Pathology Hospital of Treviso University of Padua
More informationUniversity Journal of Pre and Para Clinical Sciences
ISSN 2455 2879 Volume 2 Issue 1 2016 Metaplastic carcinoma breast a rare case report Abstract : Metaplastic carcinoma of the breast is a rare malignancy with two distinct cell lines described as a breast
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationCellular Neurothekeoma
Cellular Neurothekeoma Scott W Binder, MD Pritzker Professor of Pathology & Dermatology Sr. Vice Chair Director, Pathology Clinical Services Chief, Dermatopathology Geffen/UCLA School of Medicine Clinical
More informationDivision of Pathology
Case 38 Adult woman with a 35mm right breast lump at the 10 o clock position. Excision performed. (Case contributed by Dr Mihir Gudi, KKH) Division of Pathology Merlion, One Fullerton Singapore Diagnosis
More informationCase: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on
Case: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on imaging. There is no significant past medical history.
More informationSarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia
Case Report Sarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia Jagtap Sunil V. 1, Shukla Dhirajkumar B. 2, Jagtap Swati S. 3, Havle Abhay D. 4 1 Associate Professor, Department
More informationSolitary Fibrous Tumor of the Kidney with Massive Retroperitoneal Recurrence. A Case Presentation
246) Prague Medical Report / Vol. 113 (2012) No. 3, p. 246 250 Solitary Fibrous Tumor of the Kidney with Massive Retroperitoneal Recurrence. A Case Presentation Sfoungaristos S., Papatheodorou M., Kavouras
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationAn Overview of Genital Stromal Tumors
An Overview of Genital Stromal Tumors By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel School of Medicine
More informationA case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1
A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 1 Animal Health Trust, Newmarket, UK 2 608 Equine and Farm Vets, Rowington, UK Signalment: Horse,
More information3/27/2017. Disclosure of Relevant Financial Relationships
Ophthalmic Pathology Evening Specialty Conference USCAP 2017 5 th March, 2017 Mukul K. Divatia, MD Assistant Professor Department of Pathology & Genomic Medicine Weill Cornell Medical College Houston Methodist
More informationACCME/Disclosures ALK FUSION-POSITIVE MESENCHYMAL TUMORS. Tumor types with ALK rearrangements. Anaplastic Lymphoma Kinase. Jason L.
Companion Meeting of the International Society of Bone and Soft Tissue Pathology The Evolving Concept of Mesenchymal Tumors ALK FUSION-POSITIVE MESENCHYMAL TUMORS Jason L. Hornick, MD, PhD March 13, 2016
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationFinancial disclosures
Mesenchymal Neoplasms with Melanocytic Differentiation By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel
More informationSelected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis
Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN folpe.andrew@mayo.edu 2016 MFMER slide-1
More informationMalignant Peripheral Nerve Sheath Tumor
C H A P T E R 120 Malignant Peripheral Nerve Sheath Tumor Currently, malignant peripheral nerve sheath tumor (MPNST) is the most commonly used generic name for the neoplasms known in the past as neurosarcoma,
More informationNewer soft tissue entities
Newer soft tissue entities Examples among fibroblastic tumors Turku, May 6, 2010 Markku Miettinen, M.D. AFIP, Washington, DC Fibroblastic neoplasms Solitary fibrous tumor /Hemangiopericytoma Low-grade
More informationMyxo-inflammatory Fibroblastic sarcoma
AKA Myxo-inflammatory Fibroblastic sarcoma Acral Myxoinflammatory fibroblastic sarcomaam.j.surg.path1998; 22; 911-924 Inflammatory myxoid tumour of soft parts with bizarre giant cells [Pathol.Res.Pract.
More informationencapsulated thyroid nodule with a follicular architecture and some form of atypia. The problem is when to diagnose
Histological Spectrum of Papillary Carcinoma of Thyroid A Two Years Study Gomathi Srinivasan 1, M. Vennila 2 1 Associate Professor Pathology, Government Medical College, Omandurar Estate, Chennai 600 002
More informationPleomorphic Rhabdomyosarcoma Of The Urinary Bladder?mitating A Pelvic Mass: A Case Report
ISPUB.COM The Internet Journal of Urology Volume 11 Number 2 Pleomorphic Rhabdomyosarcoma Of The Urinary Bladder?mitating A Pelvic Mass: A Case Report C Ceylan, T A Serel, A Albayrak, O G Doluoglu Citation
More information57th Annual HSCP Spring Symposium 4/16/2016
An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no
More informationEvening Specialty Conference Bone and Soft Tissue Pathology. Diagnostic pitfalls in bone and soft tissue pathology
Evening Specialty Conference Bone and Soft Tissue Pathology. Case 1 Elizabeth G Demicco, MD, PhD Mount Sinai Hospital, New York Disclosure of Relevant Financial Relationships USCAP requires that all planners
More information3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:
Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position
More informationNormal thyroid tissue
Thyroid Pathology Overview Normal thyroid tissue Normal thyroid tissue with follicles filled with colloid. Thyroid cells form follicles, spheres of epithelial cells (always single layered in health, usually
More informationImmunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD
Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor
More informationPapillary Lesions of the Breast A Practical Approach to Diagnosis. (Arch Pathol Lab Med. 2016;140: ; doi: /arpa.
Papillary Lesions of the Breast A Practical Approach to Diagnosis (Arch Pathol Lab Med. 2016;140:1052 1059; doi: 10.5858/arpa.2016-0219-RA) Papillary lesions of the breast Span the spectrum of benign,
More informationAN AUTOPSY CASE OF PARATHYROID CARC. Matsumoto, Koji; Ito, Masahiro; Sek. Citation Acta medica Nagasakiensia. 1989, 34
NAOSITE: Nagasaki University's Ac Title Author(s) AN AUTOPSY CASE OF PARATHYROID CARC Hsu, Chao-Tien; Naito, Shinji; Shik Matsumoto, Koji; Ito, Masahiro; Sek Citation Acta medica Nagasakiensia. 1989, 34
More informationLow-Grade Periductal Stromal of Breast: a case report
Low-Grade Periductal Stromal of Breast: a case report Rosanna Nenna 1 Cosimo Damiano Inchingolo 1 Domenico Palmieri 2 Annalisa De Lucia 1 Giusy Elicio 1 Pina Miscioscia 1 ( 1 ) U.O.C. di Anatomia Patologica,
More informationAngiomatoid Fibrous Histiocytoma : A Case Report
영남의대학술지제24권제2호 Yeungnam Univ. J. of Med. Vol.24 No.2 p315-321, Dec. 2007 증례 Angiomatoid Fibrous Histiocytoma : A Case Report Joon Hyuk Choi, Woo Jung Sung, Nam Hyuk Lee* Department of Pathology, and *Department
More informationCASE REPORT PLEOMORPHIC LIPOSARCOMA OF PECTORALIS MAJOR MUSCLE IN ELDERLY MAN- CASE REPORT & REVIEW OF LITERATURE.
PLEOMORPHIC LIPOSARCOMA OF PECTORALIS MAJOR MUSCLE IN ELDERLY MAN- CASE REPORT & REVIEW OF LITERATURE. M. Madan 1, K. Nischal 2, Sharan Basavaraj. C. J 3. HOW TO CITE THIS ARTICLE: M. Madan, K. Nischal,
More informationEvening specialty conference: Liver
Evening specialty conference: Liver Joseph Misdraji, M.D. Disclosure of Relevant Financial Relationships Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee)
More informationDermatopathology. Dr. Rafael Botella Estrada. Hospital La Fe de Valencia
Dermatopathology Dr. Rafael Botella Estrada. Hospital La Fe de Valencia DERMATOPATHOLOGY CASE CHALLENGE: RECOGNIZING MIMIS AND MASQUERADERS Rosalie Elenitsas. University of Pennsylvania Spectrum Lupus
More informationGUT-C 11/30/2017. Debasmita Das, M.D. PGY-1 Danbury Hospital
GUT-C 11/30/2017 Debasmita Das, M.D. PGY-1 Danbury Hospital CLINICAL SUMMARY 8/2017 59 year old female Presented to the ED with 1 month history of general malaise, fever and weight loss PMH: Significant
More informationWorld Articles of Ear, Nose and Throat Page 1
World Articles of Ear, Nose and Throat ---------------------Page 1 Primary Malignant Melanoma of the Tongue: A Case Report Authors: Nanayakkara PR*, Arudchelvam JD** Ariyaratne JC*, Mendis K*, Jayasekera
More informationSmooth Muscle and Similar Lesions. Disclosure Statement. Smooth Muscle Tumors. Elizabeth Montgomery
Smooth Muscle and Similar Lesions Elizabeth Montgomery Disclosure Statement Dr. Montgomery reports no relevant financial relationships with commercial interests. Smooth Muscle Tumors Most are leiomyomas
More informationISPUB.COM. A Rare Bednar Tumour Of Neck. R P Singh, J Singh INTRODUCTION CASE REPORT
ISPUB.COM The Internet Journal of Pathology Volume 15 Number 1 R P Singh, J Singh Citation R P Singh, J Singh.. The Internet Journal of Pathology. 2013 Volume 15 Number 1. Abstract Bednar tumour ( pigmented
More informationUpdate in Salivary Gland Pathology. Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016
Update in Salivary Gland Pathology Benjamin L. Witt University of Utah/ARUP Laboratories February 9, 2016 Objectives Review the different appearances of a selection of salivary gland tumor types Establish
More informationIntroduction. Results. Discussion. Histopathologic and immunohistochemical findings. Results. conclusions,
1/5 2/5 Carcinoma distinctive carcinoma. form erysipeloides (CE), metastasis. which clinically Itfrom has resembles been termed erysipelas, is an uncommon, but may extend It164 toclassically back, presents
More informationNo financial or other disclosures
Case 2014-5 Esther N. Bit-Ivan, DO Northwestern University Jason Wang, MD Jason Park, MD Korgun Koral, MD Children s Medical Center Charles Timmons, MD Veena Rajaram, MD No financial or other disclosures
More informationOcular Neoplasia What s Common? What s New? Richard R Dubielzig
Ocular Neoplasia What s Common? What s New? Richard R Dubielzig Orbit 288 6% Tumors of the globe make up 3225 out of 6110 total neoplasms = 53%. Tumors of the conjunctiva make up 1192 out of 6110 total
More informationImmunohistochemical Expression Of Cytokeratin 8 And 18 In Breast Carcinoma.
ISPUB.COM The Internet Journal of Pathology Volume 13 Number 3 Immunohistochemical Expression Of Cytokeratin 8 And 18 In Breast Carcinoma. B Rattan, A Baghla, M Manjari, P Kakkar, S Kahlon, S Paul Citation
More informationClassification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al.
Non-epithelial tumours and nonepithelial tumour-like lesions of the bladder Dr Jonathan H Shanks The Christie NHS Foundation Trust, Manchester, UK Classification (1) Myofibroblastic proliferations and
More informationDiagnostic problems in uterine smooth muscle tumors
Diagnostic problems in uterine smooth muscle tumors Marina Kos Ljudevit Jurak Clinical Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb Institute of Pathology, University of
More informationFollicular Derived Thyroid Tumors
Follicular Derived Thyroid Tumors Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical Sciences
More informationCase Report Multiple intranodal leiomyomas in a patient with human immunodeficiency virus infection
Int J Clin Exp Med 2018;11(4):4242-4246 www.ijcem.com /ISSN:1940-5901/IJCEM0062351 Case Report Multiple intranodal leiomyomas in a patient with human immunodeficiency virus infection Bo-Nien Chen 1,2,
More informationTitleSarcomatoid carcinoma of the bladde.
TitleSarcomatoid carcinoma of the bladde Author(s) Takashi, Munehisa; Sakata, Takao; N Tatsuya; Miyake, Koji Citation 泌尿器科紀要 (1992), 38(1): 67-70 Issue Date 1992-01 URL http://hdl.handle.net/2433/117446
More informationPathology of Mediastinal Tumors
SAMO Meeting Lucerne 2009 Pathology of Mediastinal Tumors Alex Soltermann Most common lesions (adults) Clinical presentation 50% of the patients are asymptomatic, lesion discovered incidentally Symptoms
More information1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma
2016 MFMER slide-1 2016 MFMER slide-2 2016 MFMER slide-3 Soft Tissue Tumors Showing Melanocytic Differentiation Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester,
More informationUSCAP 2011: ASDP companion meeting. Steven D. Billings 1
USCAP 2011: ASDP companion meeting. Steven D. Billings (billins@ccf.org) 1 Spindle cell tumors that make you say, Oh $*&%! This lecture will focus on examples of cutaneous tumors that present particular
More informationKidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
More informationOncocytic carcinoma: A rare malignancy of the parotid gland
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Oncocytic carcinoma: A rare malignancy of the parotid gland K Mardi, J Sharma Citation K Mardi, J Sharma.. The Internet Journal of Pathology.
More informationMonophasic Synovial Carcinoma of knee joint- A Case Report and Review of Literature
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 17, Issue 3 Ver.5 March. (2018), PP 13-17 www.iosrjournals.org Monophasic Synovial Carcinoma of knee
More informationPathological Classification of Hepatocellular Carcinoma
3 rd APASL Single Topic Conference: HCC in 3D Pathological Classification of Hepatocellular Carcinoma Glenda Lyn Y. Pua, M.D. HCC Primary liver cancer is the 2 nd most common cancer in Asia HCC is the
More information21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells
UPDATE IN CUTANEOUS VASCULAR S DERMATOPATHOLOGY SESSION BELFAST PATHOLOGY JUNE 21/2017 Dr E Calonje St John s Institute of Dermatology, London, United Kingdom THE FAMILY OF VASCULAR S WITH EPITHELIOID
More informationInvasive Papillary Breast Carcinoma
410 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license), applicable to the online version of the
More informationEndometrial Stromal Tumors
Endometrial Stromal Tumors WHO Categories: Endometrial Stromal Nodule (ESN) Endometrial Stromal Sarcoma, low grade (LGESS) Endometrial Stromal Sarcoma, high grade (HGESS) Undifferentiated Uterine Sarcoma
More information04/10/2018. Intraductal Papillary Neoplasms Of Breast INTRADUCTAL PAPILLOMA
Intraductal Papillary Neoplasms Of Breast Savitri Krishnamurthy MD Professor of Pathology Deputy Division Head The University of Texas MD Anderson Cancer Center 25 th Annual Seminar in Pathology Pittsburgh,
More informationPart 1. Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013
Part 1 Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013 Pediatric Pathology Soft Tissue Tumors AN UPDATE Rita Alaggio Azienda Ospedaliera Università di Padova Soft Tissue Tumors More
More informationPitfalls in thyroid tumor pathology. Prof.Valdi Pešutić-Pisac MD, PhD
Pitfalls in thyroid tumor pathology Prof.Valdi Pešutić-Pisac MD, PhD Too many or... Tumour herniation through a torn capsule simulating capsular invasion fibrous capsule with a sharp discontinuity, suggestive
More informationSESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY
SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, 2008 9:30am - 11:30am FACULTY COPY GOAL: Describe the basic morphologic (structural) changes which occur in various pathologic conditions.
More informationUpdate on Cutaneous Mesenchymal Tumors. Thomas Brenn
Update on Cutaneous Mesenchymal Tumors Thomas Brenn Cutaneous Mesenchymal Tumours Wide morphological and biological spectrum Myofibroblastic, smooth muscle, neural, vascular, apidocytic, undifferentiated;
More informationNote: The cause of testicular neoplasms remains unknown
- In the 15- to 34-year-old age group, they are the most common tumors of men. - Tumors of the testis are a heterogeneous group of neoplasms that include: I. Germ cell tumors : 95%; all are malignant.
More informationDisclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012
Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features
More informationIntussuception due to gastrointestinal stromal tumor with neural differentiation in a patient with. Von Recklinghausen Neurofibromatosis,
Turkish Journal of Cancer Vol 31/ No.4 /2001 Intussuception due to gastrointestinal stromal tumor with neural differentiation in a patient with Von Recklinghausen Neurofibromatosis (NF-1): A case report
More informationA Report of a Rare Case of Anaplastic Large Cell Lymphoma of the Oral Cavity
AJMS Al Ameen J Med Sci (2 0 1 2 )5 (1 ):9 8-1 0 2 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G CASE REPORT A Report of a Rare Case of Anaplastic
More informationCase 8 Soft tissue swelling
Case 8 Soft tissue swelling 26-year-old female presented with a swelling on the back of the left knee joint since the last 6 months and chronic pain in the calf and foot since the last 2 months. Pain in
More informationMammary analogue secretory carcinoma of salivary gland A case report of new entity
Case Report Mammary analogue secretory carcinoma of salivary gland A case report of new entity Vaibhav Bhika Bari 1*, Sandhya Unmesh Bholay 2 1 Assistant Professor, 2 Associate Professor Rajiv Gandhi Medical
More informationHemangioendothelioma with a Prominent Lymphoid Infiltrate Mimicking Follicular Dendritic Cell Tumor: Report of a Case
Journal of Cancer Research Updates, 2013, 2, 135-139 135 Hemangioendothelioma with a Prominent Lymphoid Infiltrate Mimicking Follicular Dendritic Cell Tumor: Report of a Case Justin Kerstetter 1, Mia Perez
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationMyoepithelial Carcinoma: A Rare Case Report with Review
Review article: Myoepithelial Carcinoma: A Rare Case Report with Review Dr. Shilpa Parikh 1, *Dr. Bhavik Mavani 2, Dr. Jigna Shah 3,Dr.Sheetal Sharma 4 1 Professor, Dept of Oral Medicine & Radiology, Govt.
More information5/10. Pathology Soft tissue tumors. Farah Bhani. Mohammed Alorjani
5/10 Pathology Soft tissue tumors Mohammed Alorjani Farah Bhani Slides are included in this sheet. Objectives: Soft tissue tumors 1. Describe soft tissue tumors. 2. Understand the classification of soft
More informationESS: Pathologic Insights
GEIS XVI INTERNATIONAL SYMPOSIUM Seville 4th October 2018 ESS: Pathologic Insights Sílvia Bagué The Royal Marsden Hospital London (United Kingdom) I have no conflicts of interest Endometrial stromal sarcoma
More informationLeiomyosarcoma Of The Intestine With Osseous Differentiation- A Rare Presentation
International Journal Of Medical Science And Clinical Inventions Volume 2 issue 04 2015 page no. 866-871 ISSN: 2348-991X Available Online At: http://valleyinternational.net/index.php/our-jou/ijmsci Leiomyosarcoma
More informationObjectives. Atypical Glandular Cells. Atypical Endocervical Cells. Reactive Endocervical Cells
2013 California Society of Pathologists 66 th Annual Meeting San Francisco, CA Atypical Glandular Cells to Early Invasive Adenocarcinoma: Cervical Cytology and Histology Christina S. Kong, MD Associate
More informationDiagnostic Value of Immunohistochemistry in Soft Tissue Tumors
Original Article DOI: 10.21276/APALM.1637 Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors Sridevi. V*., Susruthan Muralitharan., and Thanka. J Dept of Pathology, SriMuthukumaran Medical
More information3/24/2017 DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS. Disclosure of Relevant Financial Relationships
DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason L. Hornick, M.D., Ph.D. Director of Surgical Pathology and Immunohistochemistry Brigham and Women s Hospital Professor
More informationAmong the benign intraepithelial melanocytic proliferations, Inflamed Conjunctival Nevi. Histopathological Criteria. Resident Short Reviews
Resident Short Reviews Inflamed conjunctival nevi (ICN) may suggest malignancy because of their rapid growth and atypical histology. The objective of this study was to characterize the diagnostic features
More informationRetroperitoneal schwannoma mimickin metastasis of seminoma. Author(s) Masahumi; Shimoji, Toshio; Miyake, Citation 泌尿器科紀要 (1991), 37(3):
Title Retroperitoneal schwannoma mimickin metastasis of seminoma Author(s) Takashi, Munehisa; Sakata, Takao; Z Masahumi; Shimoji, Toshio; Miyake, Citation 泌尿器科紀要 (1991), 37(3): 255-258 Issue Date 1991-03
More informationA Histologic, Immunohistochemical and Ultrastructural Study of Fibroma, Myofibroblastoma, Leiomyoma and Hemangiopericytoma in Cattle
JARQ 38 (3), 191 197 (2004) http://www.jircas.affrc.go.jp A Histologic, Immunohistochemical and Ultrastructural Study of Fibroma, Myofibroblastoma, Leiomyoma and Hemangiopericytoma in Cattle Hikaru TAKAI
More informationCase Report Inflammatory Myofibroblastic Tumor of the Nasal Septum
Case Reports in Otolaryngology Volume 2013, Article ID 670105, 4 pages http://dx.doi.org/10.1155/2013/670105 Case Report Inflammatory Myofibroblastic Tumor of the Nasal Septum Yuri Okumura, 1 Kazuhiro
More informationResearch Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes
Sarcoma Volume 2015, Article ID 740571, 5 pages http://dx.doi.org/10.1155/2015/740571 Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes Hiroshi Kobayashi,
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationProliferative Epithelial lesions of the Breast. Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London
Proliferative Epithelial lesions of the Breast Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London Amman, November2013 Proliferative Epithelial Lesions of the Breast Usual type
More informationPATHOLOGICAL COMPARATIVE ASSESSMENT OF TWO CASES OF THYMIC CYST AND CYSTIC THYMOMA AND REVIEW OF THE LITERATURE
Rev. Med. Chir. Soc. Med. Nat., Iaşi 2012 vol. 116, no. 3 INTERNAL MEDICINE - PEDIATRICS CASE REPORTS PATHOLOGICAL COMPARATIVE ASSESSMENT OF TWO CASES OF THYMIC CYST AND CYSTIC THYMOMA AND REVIEW OF THE
More information(Iteceived for publication December 3, 1915)
TRANSPLANTABLE SARCOMATA OF THE RAT LIVER ARISING IN THE WALLS OF PARASITIC CYSTS G. L. ROHDENBURG, M.D., AND F. D. BULLOCK, M.D. From Colurnbia University, George Crocker Special Re-search Fund, F. C.
More informationNeoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath
Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand
More information