1. CyberKnife Centers of San Diego, CA 2. Coast Urology La Jolla, CA 3. Sletten Cancer Center Great Falls, MT
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1 Donald B. Fuller, M.D. 1, John Naitoh, M.D. 2, Mark Reilly, M.D. 3, Chad Lee, Ph.D CyberKnife Centers of San Diego, CA 2. Coast Urology La Jolla, CA 3. Sletten Cancer Center Great Falls, MT
2 Typically, prostate Cancer is a peripheral zone disease
3 HDR Brachytherapy preferentially treats the peripheral zone
4 CK Dosimetry Model: HDR Brachytherapy: 38Gy/4 fx This has peer reviewed documentation Grills, IS, Martinez, AA, et al; J Urol 2004; 171(3); % PSA-based DFS at 35 mo. median f/u HDR brachytherapy had lower grade 2 GU toxicity incidence HDR brachytherapy had lower grade 2 GU toxicity incidence than 103 Pd seed brachytherapy in this series
5 We like everything about HDR brachytherapy except this...
6 Virtual HDR CyberKnife Working Concept: CK is a non-invasive HDR delivery tool Basic Dosimetry Goal: Recapitulate HDR Brachytherapy
7 VIRTUAL HDR CYBERKNIFE RADIOSURGERY FOR LOCALIZED PROSTATIC CARCINOMA: A PHASE II STUDY Principal Investigator Donald B. Fuller, M. D. Accrual Goal: 100 patients/4 years 40 accrued to date (+ 60 on subsequent Accuray-sponsored study) IRB approval? Yes Approved through Scripps Health IRB, San Diego Primary Objective Toxicity and quality of life evaluation Secondary Objective PSA response and PSA-based DFS evaluation Tertiary Objective Compare Virtual HDR CyberKnife Dosimetry with simulated HDR Dosimetry Accomplished
8 VIRTUAL HDR CYBERKNIFE RADIOSURGERY FOR LOCALIZED PROSTATIC CARCINOMA: A PHASE II STUDY Methods: Eligibility 40 Patients Median F/U 12 mo; Max F/U 2 years Favorable and Intermediate prognosis cases Favorable: <=T2b, Gleason <=6, PSA < 10 ng/ml 28 cases Intermediate: <=T2b, Gleason 7 or PSA ng/ml 12 cases PSA-based relapse-free survival CTCAE Toxicity evaluation Full Scale EPIC QOL evaluation
9 VIRTUAL HDR CYBERKNIFE RADIOSURGERY FOR LOCALIZED PROSTATIC CARCINOMA: A PHASE II STUDY Methods: Treatment 38 Gy/4 fx Favorable: Prostate + 2 mm (shaved to 0 mm at rectal interface) Intermediate: Prostate + 5 mm (shaved to 0 mm at rectal interface) HDR-like dose molding; >95% PTV At least 1% of PTV gets >150% of prescription dose EUD = approximately 48Gy/4fx HDR-like OAR dose constraints Outer rectal wall D max = 38Gy (100% Rx dose) Rectal mucosa D max = 28.5Gy (75% Rx dose) Bladder D max = 45.6 Gy (120% Rx dose) Urethra D max = 45.6 Gy (120% Rx dose) Urethra D 50 = 39.9 Gy (105% Rx dose)
10 Low risk PTV Intermediate risk NVB
11 Low risk Intermediate risk SV coverage
12 Speaking of Extreme Heterogeneity Assume alpha/beta = Gy/4fx; BED = 234 (140Gy/70fx) X 38Gy/4fx; BED = 158 (94Gy/47fx) X 28.5Gy/4fx; BED = 96 (58Gy/29fx)
13 Clinical Results: PSA Response Median PSA (n ng/ml) /- 1 standard deviation Median Pre-CK 1 month 2 months 4 months 6 months 12 months 18 months 24 months
14 PSA nadir: Percent of pts w PSA <= 0.5ng/ml PSA nadir: % <= 0.5 ng/ml 12 mo 18 mo 24 mo 40% 60% 100%
15 Post-CK PSA Bounce: 3 Case Examples 10/24 patients followed >= 12 months have at least one PSA bounce Pre 1 mo 2 mo 4 mo 6 mo 9 mo 12 mo 18 mo 24 mo
16 Virtual HDR IPSS Prostate changes CyberKnife for Virtual-HDR Radiosurgery: CyberKnife treatment PSA-response, of Toxicity and Quality of Life prostate Evaluation cancer IPSS sc core % 100% Post-CK Urinary Morbidity Alpha Blocker Incidence 40-67% 27% initial 2 wks 4 wks 2 mo 4mo 6 mo 12 mo 18 mo Time
17 Sexual function: SHIM Score Low Median High Pre 1 mo 3-4 mo 6 mo 12 mo 18 mo 24 mo
18 Full Scale EPIC QOL Summary n Urinary Bowel Sexual Hormonal 40 Baseline mo mo mo mo
19 Summary of Results: 40 patients Median f/u 1 yr; Max 2 yrs PSA-based DFS 100% (ASTRO and Phoenix) Median PSA 1 year ng/ml 1.5 yr ng/ml 2 yr 0.25 ng/ml Toxicity Grade III or higher - Zero CTCAE Grade 1-2 delayed GU 10% (all Grade 2) CTCAE Grade 1-2 delayed GI -10% (7% Grade 1; 3% Grade 2) EPIC Quality of Life Summary to 18 months Bladder Domain Minimal decrease at 2 months w subsequent recovery Bowel Domain No significant change Sexual Domain Decrease to 12 months followed by Recovery Hormonal Domain No significant change
20 Conclusions Virtual HDR CyberKnife Monotherapy Protocol : Very encouraging PSA response Pending longer-term confirmation it looks like brachytherapy PSA bounces are common within the first 18 months Favorable toxicity profile with typically rapid resolution Zero incidence of grade 3 toxicity to date Some patients require protracted use of alpha blockers QOL outcome is favorable
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