Advances in Radiation Therapy
|
|
- Marcus Goodwin
- 5 years ago
- Views:
Transcription
1 Advances in Radiation Therapy 2017 Recent Advances in Oncology Michelle Alonso-Basanta, MD PhD Helene Blum Assistant Professor Associate Chief of Clinical Operations Director of Quality Assurance Chief, Central Nervous System April 27, 2017
2 Disclosures IBA speaker 2
3 Radiotherapy: Overview Cancer is a complex disease from an anatomic and biologic standpoint, and therapy often requires a multidisciplinary approach Radiotherapy is a non-invasive form of cancer therapy, focused to a finite anatomic site/region It can be used alone, or in conjunction with other treatment modalities such as surgery, traditional chemotherapy, or with emerging agents such as immunotherapy Innovations in Radiotherapy: leading to improved patient outcomes and new indications for therapy 3
4 Advances in Radiotherapy 1) Radiosurgery: non-invasive, high-dose radiation to treat areas for which surgery would be difficult/morbid 2) Proton therapy: highly-focused radiation, with minimal exposure to surrounding normal tissues/organs Potential for significant improvements in side effect profile normally seen with standard radiation techniques 3) Radiotherapy in combination with immunotherapy: in patients with widespread disease, using radiation to a focused area as a way to stimulate/augment the immune system in order to obtain dramatic responses to immunotherapy agents 4
5 RADIOSURGERY Advances in Radiation Therapy 5
6 Stereotactic Radiosurgery To deliver safe, high doses of radiation to a target with little to no normal tissue exposure Number of machines that can do this 6
7 Trigeminal Neuralgia 40 Gy to the 50% 7
8 8
9 9
10 Graded Prognostic Assessment (GPA) 10
11 Median Survivals 11
12 Stereotactic Radiosurgery Good for treating brain metastases Most mets are small, spherical, and radiographically distinct, making good targets for SRS Minimally invasive and displace normal brain beyond target volume Can usually encompass entire met within target volume Avoids risks of surgery Bleeding Infection Tumor seeding Minimal hospitalization Less costly than surgery 12
13 Does SRS add anything to WBRT? Andrews et al, Lancet 2004;363:
14 Median survival: 7.5 mo vs 8 mo Recurrent rate 46.8% vs 76.4% 14
15 15
16 16
17 17
18 213 patients (34 institutions) from Median follow-up was 7.2 months Clinical characteristics well balanced Decline in cognitive function: SRS: 63.5% SRS+WBRT: 91.7% p = Trend of greater progression of cognitive deterioration for SRS plus WBRT for all cognitive tests, and there were substantial differences for immediate recall, memory, and verbal fluency QOL scores were also worse with WBRT 18
19 NCCTG N0574 Increased intracranial disease progression: 3 mo 6 mo SRS 24.7% 35.4% SRS + WBRT 6.3% 11.6% p < No significant difference in median OS SRS 10.4 mo SRS + WBRT 7.4 mo Trends for worse cognitive function with WBRT persisted in long-term survivors (16%), defined as patients alive 12 months after study entry 19
20 PROTON THERAPY Advances in Radiation Therapy 20
21 Relative Dose (%) The Physics of Protons X-rays deliver a greater dose outside the target for the same dose within the target volume as protons Depth dose curves for protons and photons MeV photons Photons Additional Dose outside the target delivered with Photons compared to Protons 150 Proton Spread Out Bragg Peak Protons Tumor Depth in Water (mm)
22 22
23 Why consider proton therapy: Head and Neck Cancer as an Example Treatment is morbid Side effects Acute Mucositis Dysgeusia Dysphagia Odynophagia (requiring opioids and/or supplemental nutrition) Xerostomia Weight loss, dehydration, malnutrition Chronic Dysgeusia Xerostomia Dysphagia (risk of feeding tube dependence) Fibrosis Lymphedema Dental caries and Osteoradionecrosis RT-induced malignancy Cerebrovascular accident 23
24 Time to severe late toxicity (shown in the graph as Treatment Failure Rates): all assessable patients. Mitchell Machtay et al. JCO 2008;26:
25 Contralateral Submandibular Gland PBS Rapid Arc IMRT: Backup plan Stage 4a, T1N2b, HPV+, R tonsil SCCA 25
26 Contralateral Submandibular Gland PBS Rapid Arc IMRT: Backup plan Mean Doses: IMRT (40 Gy), PBS (33 Gy) 26
27 Contralateral Parotid PBS Rapid Arc IMRT: Backup plan Mean Doses: IMRT (18 Gy), PBS (9 Gy) 27
28 Oral Cavity PBS Rapid Arc IMRT: Backup plan Mean Doses: IMRT (19 Gy), PBS (3 Gy) 28
29 Patient-Reported Toxicity/QOL Collected at baseline, 3, 6, 12, and 24 mos 29
30 Mean Dose (Gy) Mean Dose (Gy) UPenn Experience, Adjuvant RT (n=51) Parotid Ipsilateral Parotid (p=0.759) Contralateral Parotid (p<0.0001) VMAT PBS Submandibular Ipsilateral Submandibular (p=0.941) Contralateral Submandibular (p=0.0236) VMAT PBS
31 Mean Dose (Gy) Mean Dose (Gy) Ipsilateral Sublingual (p=0.0007) Sublingual Contralateral Sublingual (p<0.0001) VMAT PBS Buccal Ipsilateral Buccal (p<0.0001) Contralateral Buccal (p<0.0001) VMAT PBS
32 Mean Dose (Gy) Hard Palate (p<0.0001) Soft Palate (p=0.0209) Tongue (p<0.0001) Upper Lip (p<0.0001) Lower Lip (p<0.0001) VMAT PBS
33 Normal Taste (p=0.10) 33% 63% Mild-Severe Appetite Changes (p=0.015) Mild-Severe Sticky Saliva (p=0.853) 13% 53% 50% 53% PBS VMAT Moderate-Severe Xerostomia (p=0.002) 19% 73% 0% 10% 20% 30% 40% 50% 60% 70% 80% 33
34 IMMUNOTHERAPY Advances in Radiation Therapy 34
35 Radiotherapy + Immunotherapy: Case 1 9/2013: Dx w/metastatic NSCLC (R hilar mass with bone mets) carbo/taxol x 6 cycles palliative RT to R lung mass (37.5 Gy) 9/2014 5/2015: nivolumab 1/2015 5/2015: progression 35
36 5/2015: taken off nivolumab and enrolled on RADVAX study Started on pembrolizumab and given 8 Gy x 3 to paraaortic mass (6/2015) Continued on pembro after 6 cycles 36
37 no RT 5/2015 (pre-radvax) 12/ Gy x 3 37
38 Radiotherapy + Immunotherapy: Case 2 9/2013: melanoma of skin of L foot 2014: L groin mass; Bx + for melanoma 9/ /2014: ipilimumab x 4 cycles 12/ /2015: pembrolizumab x 13 cycles 12/2014 3/ /2015: progression 38
39 10/2015: enrolled on RADVAX protocol Given 17 Gy to L inguinal mass 39
40 17 Gy 10/2015 (pre-radvax) 4/2016 no RT 40
41 Summary Numerous options for treatment compared to just 5 years ago PENN has every possible modality of radiation to individualize treatment Multi-disciplinary approach 41
42 42
43 Thank you 43
Squamous Cell Carcinoma of the Oral Cavity: Radio therapeutic Considerations
Squamous Cell Carcinoma of the Oral Cavity: Radio therapeutic Considerations Troy G. Scroggins Jr. MD Chairman, Department of Radiation Oncology Ochsner Health Systems 1 Association of Postoperative Radiotherapy
More informationDemands and Perspectives of Hadron Therapy
Demands and Perspectives of Hadron Therapy Alexander Lin, M.D. Assistant Professor University of Pennsylvania Direction of Operations Roberts Proton Therapy Center Disclosures Teva Pharmaceuticals: Advisory
More informationMinesh Mehta, Northwestern University. Chicago, IL
* Minesh Mehta, Northwestern University Chicago, IL Consultant: Adnexus, Bayer, Merck, Tomotherapy Stock Options: Colby, Pharmacyclics, Procertus, Stemina, Tomotherapy Board of Directors: Pharmacyclics
More informationTreatment of Brain Metastases
1 Treatment of Brain Metastases An Overview and Pending Research Questions To Answer Olav E. Yri, MD, PhD www.ntnu.no/prc European Palliative Care Research Centre (PRC) The brain metastases diagnosis Outline
More informationThe Role of Radiation Therapy in the Treatment of Brain Metastases. Matthew Cavey, M.D.
The Role of Radiation Therapy in the Treatment of Brain Metastases Matthew Cavey, M.D. Objectives Provide information about the prospective trials that are driving the treatment of patients with brain
More informationClinical Protontherapy Head and Neck cancer
Clinical Protontherapy Head and Neck cancer Coen Rasch Department of Radiation Oncology Academic Medical Center Amsterdam No disclosures 1 Introduction Proton vsphotonin the literature Model basedindicationprotocol
More informationOral complications: an overview DR ANDREW DAVIES FRCP CONSULTANT IN PALLIATIVE MEDICINE ROYAL SURREY COUNTY HOSPITAL, GUILDFORD, UK
Oral complications: an overview DR ANDREW DAVIES FRCP CONSULTANT IN PALLIATIVE MEDICINE ROYAL SURREY COUNTY HOSPITAL, GUILDFORD, UK Introduction Introduction Outline: Epidemiology Aetiology Clinical features
More informationPalliative radiotherapy near the end of life for brain metastases from lung cancer: a populationbased
Palliative radiotherapy near the end of life for brain metastases from lung cancer: a populationbased analysis Roel Schlijper Fellow Radiation Oncology BC Cancer, Prince George Disclosures No conflicts
More information3/12/2018. Head & Neck Cancer Review INTRODUCTION
Head & Neck Cancer Review Joseph Rosales, MD March 12, 2018 INTRODUCTION Epidemiology/Risk Factors Anatomy Presentation/Workup Treatment Surgery vs Radiation Chemotherapy Side effects Special circumstances
More informationRevisiting the Role of Radiation Therapy in Advanced Disease
Revisiting the Role of Radiation Therapy in Advanced Disease Abigail T. Berman, MD, MSCE Dept. of Radiation Oncology Perelman School of Medicine of University of Pennsylvania 6/21/18 2018 New Advances
More informationHot topics in Radiation Oncology for the Primary Care Providers
Hot topics in Radiation Oncology for the Primary Care Providers Steven Feigenberg, MD Professor Chief, Thoracic Oncology Vice Chair of Clinical Research April 19, 2018 Disclosures NONE 2 Early Stage Disease
More informationSarcoma and Radiation Therapy. Gabrielle M Kane MB BCh EdD FRCPC Muir Professorship in Radiation Oncology University of Washington
Sarcoma and Radiation Therapy Gabrielle M Kane MB BCh EdD FRCPC Muir Professorship in Radiation Oncology University of Washington Objective: Helping you make informed decisions Introduction Process Radiation
More informationOptimal Management of Isolated HER2+ve Brain Metastases
Optimal Management of Isolated HER2+ve Brain Metastases Eliot Sims November 2013 Background Her2+ve patients 15% of all breast cancer Even with adjuvant trastuzumab 10-15% relapse Trastuzumab does not
More informationAlleinige Radiochirurgie und alleinige Systemtherapie zwei «extreme» Entwicklungen in der Behandlung von Hirnmetastasen?
Department of Radiation Oncology Chairman: Prof. Dr. Matthias Guckenberger Alleinige Radiochirurgie und alleinige Systemtherapie zwei «extreme» Entwicklungen in der Behandlung von Hirnmetastasen? Matthias
More informationUPDATE ON RADIOTHERAPY
1 Miriam Kleiter UPDATE ON RADIOTHERAPY Department for Companion Animals and Horses, Plattform Radiooncology and Nuclear Medicine, University of Veterinary Medicine Vienna Introduction Radiotherapy has
More informationMehmet Ufuk ABACIOĞLU Neolife Medical Center, İstanbul, Turkey
Updated Oncology 2015: State of the Art News & Challenging Topics CURRENT STATUS OF STEREOTACTIC RADIOSURGERY IN BRAIN METASTASES Mehmet Ufuk ABACIOĞLU Neolife Medical Center, İstanbul, Turkey Bucharest,
More informationRadiation Therapy and Immunotherapy: New Frontiers
Radiation Therapy and Immunotherapy: New Frontiers Nevada Oncology Society Fall Meeting November 16 th, 2017 Anshu K. Jain, MD Radiation Oncologist, Ashland Bellefonte Cancer Center Assistant Clinical
More informationSociety for Immunotherapy of Cancer (SITC) Immunotherapy for the Treatment of Brain Metastases
Society for Immunotherapy of Cancer (SITC) Immunotherapy for the Treatment of Brain Metastases Geoffrey T. Gibney, MD Georgetown-Lombardi Comprehensive Cancer Center Medstar-Georgetown University Hospital
More informationRadiotherapy and Brain Metastases. Dr. K Van Beek Radiation-Oncologist BSMO annual Meeting Diegem
Radiotherapy and Brain Metastases Dr. K Van Beek Radiation-Oncologist BSMO annual Meeting Diegem 24-02-2017 Possible strategies Watchful waiting Surgery Postop RT to resection cavity or WBRT postop SRS
More informationGamma Knife Radiosurgery A tool for treating intracranial conditions. CNSA Annual Congress 2016 Radiation Oncology Pre-congress Workshop
Gamma Knife Radiosurgery A tool for treating intracranial conditions CNSA Annual Congress 2016 Radiation Oncology Pre-congress Workshop ANGELA McBEAN Gamma Knife CNC State-wide Care Coordinator Gamma Knife
More informationProtons for Head and Neck Cancer. William M Mendenhall, M.D.
Protons for Head and Neck Cancer William M Mendenhall, M.D. Protons for Head and Neck Cancer Potential Advantages: Reduce late complications via more conformal dose distributions Likely to be the major
More informationStereotactic Ablative Radiotherapy for Prostate Cancer
Stereotactic Ablative Radiotherapy for Prostate Cancer Laurie Cuttino, MD Associate Professor of Radiation Oncology VCU Massey Cancer Center Director of Radiation Oncology Sarah Cannon Cancer Center at
More informationUse of radiation to kill diseased cells. Cancer is the disease that is almost always treated when using radiation.
Radiation Therapy Use of radiation to kill diseased cells. Cancer is the disease that is almost always treated when using radiation. One person in three will develop some form of cancer in their lifetime.
More informationCollection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org The Management of Brain Metastases Dr. Luis Souhami Professor Department of Radiation Oncology University,
More informationFROM ICARO1 TO ICARO2: THE MEDICAL PHYSICS PERSPECTIVE. Geoffrey S. Ibbott, Ph.D. June 20, 2017
FROM ICARO1 TO ICARO2: THE MEDICAL PHYSICS PERSPECTIVE Geoffrey S. Ibbott, Ph.D. June 20, 2017 1 DISCLOSURES My institution holds Strategic Partnership Research Agreements with Varian, Elekta, and Philips
More informationNew Radiation Treatment Modalities in the Treatment of Lung Cancer
New Radiation Treatment Modalities in the Treatment of Lung Cancer David Perry, M.D. Chief, Radiation Oncology Medical Director, CyberKnife Radiosurgery Center Medstar Franklin Square Medical Center Definitions
More informationCancer of the Head and Neck and. HPV Infection. Andrew Urquhart MD, FACS Dept. Otolaryngology/Head and Neck Surgery Marshfield Clinic
Cancer of the Head and Neck and HPV Infection Andrew Urquhart MD, FACS Dept. Otolaryngology/Head and Neck Surgery Marshfield Clinic Disclaimer I have no relevant financial relationships with the manufacturer(s)
More informationPaolo Bossi Head and Neck Medical Oncology Unit Istituto Nazionale Tumori Milan, Italy
Orphan Symptoms: XEROSTOMIA Paolo Bossi Head and Neck Medical Oncology Unit Istituto Nazionale Tumori Milan, Italy Conflict of Interest Participation in Advisory Boards: Roche, Merck, Mundipharma, Astrazeneca,
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: charged_particle_radiotherapy 3/12/96 5/2017 5/2018 5/2017 Description of Procedure or Service Charged-particle
More informationFINE NEEDLE ASPIRATION OF ENLARGED LYMPH NODE: Metastatic squamous cell carcinoma
Case Scenario 1 HNP: A 70 year old white male presents with dysphagia. The patient is a current smoker, current user of alcohol and is HPV positive. A CT of the Neck showed mass in the left pyriform sinus.
More informationDisclosures. Overview 8/3/2016. SRS: Cranial and Spine
SRS: Cranial and Spine Brian Winey, Ph.D. Department of Radiation Oncology Massachusetts General Hospital Harvard Medical School Disclosures Travel and research funds from Elekta Travel funds from IBA
More informationPalliative radiotherapy in lung cancer
New concepts and insights regarding the role of radiation therapy in metastatic disease Umberto Ricardi University of Turin Department of Oncology Radiation Oncology Palliative radiotherapy in lung cancer
More informationEVERYTHING YOU WANTED TO KNOW ABOUT. Robin Billet, MA, CTR, Head & Neck CTAP Member May 9, 2013
EVERYTHING YOU WANTED TO KNOW ABOUT. Robin Billet, MA, CTR, Head & Neck CTAP Member May 9, 2013 Head and Neck Coding and Staging Head and Neck Coding and Staging Anatomy & Primary Site Sequencing and MPH
More informationHong Kong Hospital Authority Convention 2018
Hong Kong Hospital Authority Convention 2018 Stereotactic Radiosurgery in Brain Metastases - Development of the New Treatment Paradigm in HA, Patients Profiles and Their Clinical Outcomes 8 May 2018 Dr
More informationCase Scenario. 7/13/12 Anterior floor of mouth biopsy: Infiltrating squamous cell carcinoma, not completely excised.
Case Scenario 7/5/12 History A 51 year old white female presents with a sore area on the floor of her mouth. She claims the area has been sore for several months. She is a current smoker and user of alcohol.
More informationSimultaneous Integrated Boost or Sequential Boost in the Setting of Standard Dose or Dose De-escalation for HPV- Associated Oropharyngeal Cancer
Simultaneous Integrated Boost or Sequential Boost in the Setting of Standard Dose or Dose De-escalation for HPV- Associated Oropharyngeal Cancer Dawn Gintz, CMD, RTT Dosimetry Coordinator of Research and
More informationDe-Escalate Trial for the Head and neck NSSG. Dr Eleanor Aynsley Consultant Clinical Oncologist
De-Escalate Trial for the Head and neck NSSG Dr Eleanor Aynsley Consultant Clinical Oncologist 3 HPV+ H&N A distinct disease entity Leemans et al., Nature Reviews, 2011 4 Good news Improved response to
More informationStereotactic Radiosurgery for Brain Metastasis: Changing Treatment Paradigms. Overall Clinical Significance 8/3/13
Stereotactic Radiosurgery for Brain Metastasis: Changing Treatment Paradigms Jason Sheehan, MD, PhD Departments of Neurosurgery and Radiation Oncology University of Virginia, Charlottesville, VA USA Overall
More informationStereotactic Radiosurgery for Intracranial Metastases
Stereotactic Radiosurgery for Intracranial Metastases Michelle Alonso-Basanta, MD PhD Helene Blum Assistant Professor Chief, Central Nervous System Section Associate Chief of Clinical Operations Department
More informationCase Scenario 1. 7/13/12 Anterior floor of mouth biopsy: Infiltrating squamous cell carcinoma, not completely excised.
Case Scenario 1 7/5/12 History A 51 year old white female presents with a sore area on the floor of her mouth. She claims the area has been sore for several months. She is a current smoker and user of
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM BRAIN METASTASES CNS Site Group Brain Metastases Author: Dr. Norm Laperriere Date: February 20, 2018 1. INTRODUCTION
More informationTania Kaprealian, M.D. Assistant Professor UCLA Department of Radiation Oncology August 22, 2015
Tania Kaprealian, M.D. Assistant Professor UCLA Department of Radiation Oncology August 22, 2015 Most common brain tumor, affecting 8.5-15% of cancer patients. Treatment options: Whole brain radiation
More informationOverview: Immunotherapy in CNS Metastases
Overview: Immunotherapy in CNS Metastases Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland Clinic Disclosures Consultant- Monteris
More informationRADIO- AND RADIOCHEMOTHERAPY OF HEAD AND NECK TUMORS. Zoltán Takácsi-Nagy PhD Department of Radiotherapy National Institute of Oncology, Budapest 1.
RADIO- AND RADIOCHEMOTHERAPY OF HEAD AND NECK TUMORS Zoltán Takácsi-Nagy PhD Department of Radiotherapy National Institute of Oncology, Budapest 1. 550 000 NEW PATIENTS/YEAR WITH HEAD AND NECK CANCER ALL
More informationAdvances in external beam radiotherapy
International Conference on Modern Radiotherapy: Advances and Challenges in Radiation Protection of Patients Advances in external beam radiotherapy New techniques, new benefits and new risks Michael Brada
More informationMANAGEMENT OF LOCALLY ADVANCED OROPHARYNGEAL CANER: HPV AND NON-HPV MEDIATED CANCERS
MANAGEMENT OF LOCALLY ADVANCED OROPHARYNGEAL CANER: HPV AND NON-HPV MEDIATED CANCERS Kyle Arneson, MD PhD Avera Medical Group Radiation Oncology Avera Cancer Institute 16 th Annual Oncology Symposium September
More informationCombined treatment of Brain metastases: Radiosurgery and Targeted therapy
Combined treatment of Brain metastases: Radiosurgery and Targeted therapy Stephanie Kroeze, MD PhD OVERVIEW Introduction brain metastases Targeted therapy as monotherapy Efficacy of SRS combined with Targeted
More informationNCCN GUIDELINES ON PROTON THERAPY (AS OF 4/23/18) BONE (Version , 03/28/18)
BONE (Version 2.2018, 03/28/18) NCCN GUIDELINES ON PROTON THERAPY (AS OF 4/23/18) Radiation Therapy Specialized techniques such as intensity-modulated RT (IMRT); particle beam RT with protons, carbon ions,
More informationPrinciples of Management of Head & Neck Cancer. Jinka Sathya Associate professor of Oncology
Principles of Management of Head & Neck Cancer Jinka Sathya Associate professor of Oncology Oral cavity Oro-pharynx Larynx Hypopharynx Nasophaynx Major sites of Mucosal H&N Cancers Head & Neck Cancer Oral
More informationBrain mets under I.O.
Brain mets under I.O. Bernard Escudier Gustave Roussy, Villejuif, France Disclosure Honorarium received from BMS, Novartis, Pfizer, Bayer, Roche, Exelixis, Ipsen, Eisai, Calithera Travel Grant from BMS,
More informationFuture of Radiation Therapy
Future of Radiation Therapy JP Morgan Healthcare Conference January 12, 2016 Deepak Khuntia, MD, VP of Medical Affairs Patrick Kupelian, MD, VP of Clinical Affairs Cancer as a cause of death CANCER TREATMENT
More informationDiagnosis and what happens after referral
Diagnosis and what happens after referral Dr Kate Newbold Consultant in Clinical Oncology The Royal Marsden Women's cancers Breast cancer introduction 1 Treatment Modalities Early stage disease -larynx
More informationRola brachyterapii w leczeniu wznów nowotworów języka i dna jamy ustnej. The role of brachytherapy in recurrent. oral cavity
Rola brachyterapii w leczeniu wznów nowotworów języka i dna jamy ustnej The role of brachytherapy in recurrent tumours of the tongue and fundus of the oral cavity Janusz Skowronek, MD, PhD, Ass. Prof.
More informationUpdate on management of metastatic brain disease. Peter Hoskin Mount Vernon Cancer Centre Northwood UK
Update on management of metastatic brain disease Peter Hoskin Mount Vernon Cancer Centre Northwood UK Incidence 15-30% of patients with solid tumours will develop brain metastases Most common primary sites
More informationProton and heavy ion radiotherapy: Effect of LET
Proton and heavy ion radiotherapy: Effect of LET As a low LET particle traverses a DNA molecule, ionizations are far apart and double strand breaks are rare With high LET particles, ionizations are closer
More informationThierry M. Muanza, MSc, MD, FRCPC,, McGill University Segal Cancer Centre, Jewish General Hospital Montreal, QC, Canada
Thierry M. Muanza, MSc, MD, FRCPC,, McGill University Segal Cancer Centre, Jewish General Hospital Montreal, QC, Canada Déclarations Aucun conflit d intérêt Objectifs d apprentissage Évolution de la radiothérapie
More informationRadiation Therapy: From Fallacy to Science
27 th Annual Management of Colon and Rectal Diseases 2.23.2019 Radiation Therapy: From Fallacy to Science Hadi Zahra, MD, DABR Radiation Oncologist CHI Health Henry Lynch Cancer Center Assistant Clinical
More informationTreating Multiple. Brain Metastases (BM)
ESTRO 36 5-9 May 2017, Vienna Austria, Accuray Symposium Treating Multiple Brain Metastases (BM) with CyberKnife System Frederic Dhermain MD PhD, Radiation Oncologist Gustave Roussy University Hospital,
More informationHead and Neck Cancer in FA: Risks, Prevention, Screening, & Treatment Options David I. Kutler, M.D., F.A.C.S.
Head and Neck Cancer in FA: Risks, Prevention, Screening, & Treatment Options David I. Kutler, M.D., F.A.C.S. Associate Professor Division of Head and Neck Surgery Department of Otolaryngology-Head and
More informationThoracic Recurrences. Soft tissue recurrence
Stereotactic body radiotherapy for thoracic and soft malignancies Alexander Gottschalk, M.D., Ph.D. Associate Professor Director of CyberKnife Radiosurgery Department of Radiation Oncology University of
More informationSelecting the Optimal Treatment for Brain Metastases
Selecting the Optimal Treatment for Brain Metastases Clinical Practice Today CME Co-provided by Learning Objectives Upon completion, participants should be able to: Understand the benefits, limitations,
More informationOutline. WBRT field. Brain Metastases. Whole Brain RT Prophylactic WBRT Stereotactic radiosurgery (SRS) 1 fraction Stereotactic frame
Radiation Therapy for Advanced NSC Lung Ca Alexander Gottschalk, M.D., Ph.D. Associate Professor Director of CyberKnife Radiosurgery Department of Radiation Oncology University of California San Francisco
More informationLung Cancer. Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD
Lung Cancer Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD Objectives Describe risk factors, early detection & work-up of lung cancer. Define the role of modern treatment options, minimally invasive
More informationFirst, how does radiation work?
Hello, I am Prajnan Das, Faculty Member in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. We are going to talk today about some of the basic principles regarding
More informationReflex Testing Guidelines for Immunotherapy in Non-Small Cell Lung Cancer
Reflex Testing Guidelines for Immunotherapy in Non-Small Cell Lung Cancer Jimmy Ruiz, MD Assistant Professor Thoracic Oncology Program Wake Forest Comprehensive Cancer Center Disclosures I have no actual
More informationPalliative RT in Ovarian cancer
Outline Palliative RT in Ovarian cancer Case discussion Palliative treatment Radiation Techniques Asst Prof Pittaya Dankulchai, MD. Division of Radiation Oncology, Department of Radiology, Faculty of Medicine
More informationThe role of chemoradiotherapy in GE junction and gastric cancer. Karin Haustermans
The role of chemoradiotherapy in GE junction and gastric cancer Karin Haustermans Overview Postoperative chemoradiotherapy Preoperative chemoradiotherapy Palliative radiation Technical aspects Overview
More informationConcurrent Chemo- and Radiotherapy for Ororpharynx Cancer
Concurrent Chemo- and Radiotherapy for Ororpharynx Cancer Faye Johnson MD, PhD Associate Professor Thoracic/Head and Neck Medical Oncology August 2017 Objectives Review data that support concurrent chemo-
More informationWHAT S HOT IN MELANOMA CNS METASTASES?
WHAT S HOT IN MELANOMA CNS METASTASES? GIUSEPPE MINNITI, MD, PHD Radiation Unit, UPMC, Hillman Cancer Center, San Pietro Hospital, Rome, and IRCCS Neuromed, Pozzilli (IS), Italy Marseille, September 21-22,
More informationManagement of Brain Metastases Sanjiv S. Agarwala, MD
Management of Brain Metastases Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA, USA Incidence (US):
More informationState of the Art Radiotherapy for Pediatric Tumors. Suzanne L. Wolden, MD Memorial Sloan-Kettering Cancer Center
State of the Art Radiotherapy for Pediatric Tumors Suzanne L. Wolden, MD Memorial Sloan-Kettering Cancer Center Introduction Progress and success in pediatric oncology Examples of low-tech and high-tech
More informationInmunoterapia Desarrollo clínico: oportunidades entorno a SBRT
Inmunoterapia Desarrollo clínico: oportunidades entorno a SBRT Felipe A. Calvo Hospital General Universitario Gregorio Marañon Madrid, España ALATRO 2017 Radio-inmunotherapy: clinical update 2017 From
More informationCancer of the Oral Cavity
The International Federation of Head and Neck Oncologic Societies Current Concepts in Head and Neck Surgery and Oncology Cancer of the Oral Cavity Ashok Shaha Principals of Management of Oral Cancer A)
More informationRadiotherapy What are our options and what is on the horizon. Dr Kevin So Specialist Radiation Oncologist Epworth Radiation Oncology
Radiotherapy What are our options and what is on the horizon Dr Kevin So Specialist Radiation Oncologist Epworth Radiation Oncology Outline Advances in radiotherapy technique Oligo - disease Advancements
More informationAdjuvant Therapy in Locally Advanced Head and Neck Cancer. Ezra EW Cohen University of Chicago. Financial Support
Adjuvant Therapy in Locally Advanced Head and Neck Cancer Ezra EW Cohen University of Chicago Financial Support This program is made possible by an educational grant from Eli Lilly Oncology, who had no
More informationOral Cavity Cancer Combined modality therapy
Oral Cavity Cancer Combined modality therapy Dr. Christos CHRISTOPOULOS Radiation Oncologist Head and Neck Cancers Centre Hospitalier Universitaire (C.H.U.) de Limoges, France Disclosure slide I have no
More informationMetastasi cerebrali La Radioterapia: tecnica, frazionamento, radiosensibilizzanti
Metastasi cerebrali La Radioterapia: tecnica, frazionamento, radiosensibilizzanti Brain Metastases Radiation Therapy of multiple brain metastases Is treatment appropriate? - Survival - QoL Brain Metastases
More informationShyana Sadiq DFM 484: MNT Case Study 33: Esophageal Cancer Treated with Surgery and Radiation 10/14/2013
Shyana Sadiq DFM 484: MNT Case Study 33: Esophageal Cancer Treated with Surgery and Radiation 10/14/2013 I. Understanding the Disease and Pathophysiology 1. Mr. Seyer has been diagnosed with adenocarcinoma
More informationLung Cancer Radiotherapy
Lung Cancer Radiotherapy Indications, Outcomes, and Impact on Survivorship Care Malcolm Mattes, MD Assistant Professor WVU Department of Radiation Oncology When people think about radiation, they think
More informationEmerging Role of Immunotherapy in Head and Neck Cancer
Emerging Role of Immunotherapy in Head and Neck Cancer Jared Weiss, MD Associate Professor of Medicine and Section Chief of Thoracic and Head/Neck Oncology UNC Lineberger Comprehensive Cancer Center Copyright
More informationIs it cost-effective to treat brain metastasis with advanced technology?
Is it cost-effective to treat brain metastasis with advanced technology? Cost-effectiveness analysis of whole brain RT, stereotactic radiosurgery and craniotomy in HA setting Lam, Tai-Chung, Choi CW Horace,
More informationPlace of tumor bed radiosurgery and focal radiotherapy following resec7on of brain metastases: A new paradigm Lucyna Kepka
Place of tumor bed radiosurgery and focal radiotherapy following resec7on of brain metastases: A new paradigm Lucyna Kepka Department of Radia7on Oncology; M. Sklodowska- Curie Memorial Cancer Center and
More informationACOSOG (NCCTG, CALGB) Alliance Thoracic Committee Kemp H. Kernstine, MD PhD
ACOSOG (NCCTG, CALGB) Alliance Thoracic Committee Kemp H. Kernstine, MD PhD 7-12-12 ACOSOG Thoracic Committee Chair: Bryan Meyers, M.D., MPH Vice Chairs: Malcolm Brock, MD Tom DiPetrillo, M.D. Ramaswamy
More informationIndex. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Ablative therapy, nonsurgical, for pulmonary metastases of soft tissue sarcoma, 279 280 Adipocytic tumors, atypical lipomatous tumor vs. well-differentiated
More informationManagement of the patient with Lymph Node Involvement. Michael A Henderson Peter MacCallum Cancer Center Univ of Melbourne
Management of the patient with Lymph Node Involvement Michael A Henderson Peter MacCallum Cancer Center Univ of Melbourne Lymph Node Field Recurrence Most important prognostic factor for early stage melanoma
More informationPotential benefits of intensity-modulated proton therapy in head and neck cancer van de Water, Tara Arpana
University of Groningen Potential benefits of intensity-modulated proton therapy in head and neck cancer van de Water, Tara Arpana IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationHDR Brachytherapy for Skin Cancers. Joseph Lee, M.D., Ph.D. Radiation Oncology Associates Fairfax Hospital
HDR Brachytherapy for Skin Cancers Joseph Lee, M.D., Ph.D. Radiation Oncology Associates Fairfax Hospital No conflicts of interest Outline Case examples from Fairfax Hospital Understand radiation s mechanism
More informationSalivary Glands. The glands are found in and around your mouth and throat. We call the major
Salivary Glands Where Are Your Salivary Glands? The glands are found in and around your mouth and throat. We call the major salivary glands the parotid, submandibular, and sublingual glands. They all secrete
More informationHead and Neck Reirradiation: Perils and Practice
Head and Neck Reirradiation: Perils and Practice David J. Sher, MD, MPH Department of Radiation Oncology Dana-Farber Cancer Institute/ Brigham and Women s Hospital Conflicts of Interest No conflicts of
More informationRe-irradiation with or without chemotherapy. Jozsef Lövey National Institute of Oncology, Budapest, Hungary
Re-irradiation with or without chemotherapy Jozsef Lövey National Institute of Oncology, Budapest, Hungary Disclosures Occasional advisory board and educational activity to Merck, Roche, Nutricia, Takeda,
More informationTrimodality Therapy for Muscle Invasive Bladder Cancer
Trimodality Therapy for Muscle Invasive Bladder Cancer Brita Danielson, MD, FRCPC Radiation Oncologist, Cross Cancer Institute Assistant Professor, Department of Oncology University of Alberta Edmonton,
More informationBrain metastases and meningitis carcinomatosa: Prof. Rafal Dziadziuszko Medical University of Gdańsk, Poland
Brain metastases and meningitis carcinomatosa: a palliative situation? Prof. Rafal Dziadziuszko Medical University of Gdańsk, Poland SAMO, Lucerne, February 1-2, 2013 Treatment options for NSCLC patients
More informationRefresher Course EAR TUMOR. Sasikarn Chamchod, MD Chulabhorn Hospital
Refresher Course EAR TUMOR Sasikarn Chamchod, MD Chulabhorn Hospital Reference: Perez and Brady s Principles and Practice of radiation oncology sixth edition Outlines Anatomy Epidemiology Clinical presentations
More informationHead and Neck Radiation Treatment and Your Oral Health
Head and Neck Radiation Treatment and Your Oral Health This booklet focuses on preventing and managing oral complications of cancer therapy. Developed by the Oral Health Center, College of Dental Medicine,
More informationMANAGEMENT OF CA HYPOPHARYNX
MANAGEMENT OF CA HYPOPHARYNX GENERAL TREATMENT RECOMMENDATIONS BASED ON HYPOPHARYNX TUMOR STAGE For patients presenting with early-stage definitive radiotherapy alone or voice-preserving surgery are viable
More informationTreating Brain Metastases in the Changing World of Oncology: Matthew Ewend, MD Kay and Van Weatherspoon Professor Chair, Department of Neurosurgery
Treating Brain Metastases in the Changing World of Oncology: Matthew Ewend, MD Kay and Van Weatherspoon Professor Chair, Department of Neurosurgery Disclosures Consultant: None Stock Holdings: None Paid
More informationFlattening Filter Free beam
Dose rate effect in external radiotherapy: biology and clinic Marta Scorsetti, M.D. Radiotherapy and Radiosurgery Dep., Istituto Clinico Humanitas, Milan, Italy Brescia October 8th/9th, 2015 Flattening
More informationAdjuvant therapy for thyroid cancer
Carcinoma of the thyroid Adjuvant therapy for thyroid cancer John Hay Department of Radiation Oncology Vancouver Cancer Centre Department of Surgery UBC 1% of all new malignancies 0.5% in men 1.5% in women
More informationTargeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care
Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland
More informationNICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36
Cancer of the upper aerodigestive e tract: assessment and management in people aged 16 and over NICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36 NICE 2018. All rights reserved. Subject
More information