5/10. Pathology Soft tissue tumors. Farah Bhani. Mohammed Alorjani

Size: px
Start display at page:

Download "5/10. Pathology Soft tissue tumors. Farah Bhani. Mohammed Alorjani"

Transcription

1 5/10 Pathology Soft tissue tumors Mohammed Alorjani Farah Bhani

2 Slides are included in this sheet. Objectives: Soft tissue tumors 1. Describe soft tissue tumors. 2. Understand the classification of soft tissue tumors 3. Understand the importance of cytologic and histologic features of soft tissue tumors in identifying type and behavior 4. Discuss the commonest benign and malignant soft tissue tumors. General Characteristics: Soft tissue tumors are classified according to the tissue of origin, (Some examples of soft tissue tumors do not have a definite tissue or cell of origin ' an example will be mentioned later in this lecture.) Any age; some prefer to occur in young people whereas others prefer to occur in young adults/adults or in the elderly. Present as an enlarging mass May be part of inherited syndromes, like: Neurofibromatosis, type I Li-Fraumeni Syndrome: (Inherited; p53 mutation, associated with osteosarcoma) Some have specific gene lesions Malignant tumors arise de novo or after recurrent Benign tumors SARCOMA Usually benign tumors stay benign, this is the ideal scenario but every rule has an exception, an example is the Tubular adenoma that grows in the colon, also known as the "Tubulovillous adenoma" whether it was sporadic or familial, these adenomas can show low grade dysplasia or high grade dysplasia but they are considered benign lesions that can transform into malignant lesions.

3 Classification of Soft tissue tumors: This is a simplified list of soft tumors, derived from the WHO list of tumors. Notes: -oma is benign and sarcoma is the malignant counterpart. Sarcoma: Malignancy in soft tissue, connective tissue and bones. Adipose tissue: Lipoma - Liposarcoma Fibrous tissue: Fibroma - Fibrosarcoma Fibrohistiocytic tumors: Distinctive tumors in which we find both fibroblasts and macrophage like cells in a part of the lesion. Smooth muscle: Leiomyoma - Leiomyosarcoma Skeletal muscle: Rhabdomyoma - Rhabdomyosarcoma Benign skeletal muscles are rarely encountered, the majority are malignant. Rhabdomyoma: may affect the tongue, heart and rarely the skeletal muscles, so generally speaking it is rare. Vascular tumors: Hemangioma Angiosarcoma (blood vessels) Lymphangioma Angiosarcoma (lymphatic vessels) There are many examples of benign, borderline malignant and malignant vascular tumors, but they won't be covered in this lecture. Peripheral nerve sheath tumors: derived from the sheath of peripheral nerves

4 Ex: Schwannoma: benign peripheral nerve sheath tumor arising from Schwann cells. Ex: Neurofibroma: consists of a collection of Schwann cells, fibroblasts and perineurial cells forming a benign mass. The malignant counterpart is known as: 'Malignant peripheral nerve sheath tumor' 'MPNST'. The last group in this classification are: Tumors of unknown exact cell of origin, these are difficult and have not yet been thoroughly understood and discovered. Malignant soft tissue tumors are graded according to differentiation, mitoses and necrosis into grade I III In the pathology practice there are two systems for grading soft tissue tumors: -American system 'NCI' -French system ' FNCLCC' which is more generally accepted according to the WHO in grading soft tissue tumors. As mentioned above they grade it according to three parameters: Differentiation: which is the degree of resemblance of the tumor cells to the cells of origin The number of Mitoses The presence/absence of Necrosis or the portion of the tumor that is necrotic. You score the patient according to these parameters, sum up the score then grade the patient's case from I-III I being low grade, II being intermediate, III being high. Grade I (Low grade) may recur but rarely metastasizes. Grade III (High grade) high risk or recurrence after excision, and a high risk of spreading away from the area or origin.

5 *The importance of grading malignant tumors lies in the fact that it helps in predicting the behavior and estimating the prognosis of the tumor, if it were Grade I I'd expect it to be locally acting and rarely metastatic, however if it was Grade III I'd expect it to expand from the area it originated. The prognosis depends on: Type; skeletal, fat etc... Grade Stage: whether the tumor had spread locally to adjacent structures or spread distally like to the lymph nodes. One of the most important parameters when it comes to the stage is the size; Tumors <=5cm are more favorable than tumors that are larger in size because smaller tumors are associated with lower metastatic rates generally speaking. Tumors <=5cm Mets rate: 30%. 'Smaller=lower mets rate' Location: superficial better. **If I am talking about tumors in the extremities or subcutaneous fat 'above the fascia' those are considered superficial. Below the fascia into the muscles and deeper soft tissues those are classified as deep. Generally speaking superficial soft tissue tumors are usually benign and have better prognosis, on the other hand deep tumors could be either benign or malignant, but in the case of a large, deep soft tissue tumor, it is more likely to be malignant and I need to do further investigation to confirm this finding. Tumors of Adipose tissue Lipoma: Commonest of soft tissue tumors Most in subcutaneous tissue meaning it is a superficial disease Usually small in size 'Lipoma could be large and deep but statistically speaking it is usually small and superficial' Single or multiple, may be familial No malignant transformation 'generally speaking'

6 Grossly: Circumscribed yellow mass Histologically: Mature fatty tissue Many histological variants: Pathologist must keep this in mind while diagnosing a tumor as it may lead to other possibilities or an erroneous diagnosis. Liposarcoma: Ex: Myxoid Lipomas, Chondroid Lipomas and Pleomorphic Lipomas **Pleomorphic Lipomas contain large Pleomorphic cells and have certain characteristics in terms of their location and their size, but they can be misdiagnosed as Liposarcomas, that is why pathologists should always consider the histological variants. *In some cases the physician may face challenges in which the tumor was identified as a Lipoma but after excision it recurred and was later re-identified into a Liposarcoma, in this case it was found after investigation that this tumor was originally a Liposarcoma but was misdiagnosed. Adults: years Usually occurs in the deep soft tissue of the extremities & retroperitoneum Grossly: Large >5cm, yellow glistening mass Histologically: According to the grade: Low grade 'I': Well differentiated (Amp. 12q, MDM2 gene) **Alteration In the shape of chromosome 12 'giant shape' also Amplification of the MDM2 gene that stimulates proliferation and is controlled by the P53 gene. Intermediate grade 'II': Myxoid type (t(12;16)) **Translocation of chromosome 12, this genetic abnormality involves two genes, forming a fusion gene that ends in the development of this tumor. High grade: Round cell Liposarcoma & Pleomorphic cell liposarcoma.

7 (The Round cell liposarcoma is the end of the spectrum of the myxoid liposarcoma, it shows many round cells and is given a high grade classification because its behavior shows aggressive tendencies in comparison with the myxoid, although both are them are considered the same disease in terms of genetics (t(12;16))and biology but the difference is in the aggressive nature of the Round cell Liposarcoma.) Diagnosis depends on identification of lipoblasts, because liposarcomas are tumors of immature cells unlike lipomas, which consist of mature fatty tissue. In some cases other findings are searched for to make a Liposarcoma diagnosis. Prognosis depends on type and sight: Well differentiated Liposarcoma likes to occur in two sights: 1. Deep parts of the extremities such as the deep soft tissue of the thigh 2. Peritoneum **It behaves similarly in both sights but since the peritoneum is somewhat hidden and spacious, the tumor reaches a large size up to 20 cm before it gets discovered, that is why I expect it to have a worse prognosis in the peritoneum, although they only differ in the terms of location. **Well differentiated liposarcomas in the peritoneum could be dedifferentiated at the time of discovery or after excision and recurrence.

8 Lipoma: Mature fat cells. These fat cells seem mature, but if we take a second look we will notice the presence of occasional lipoblasts, hyalinized fibrous stroma and atypical spindle cells indicating that this is a diseased lipoma sight.

9 **Myxoid liposarcoma: background is myxoid, there are some lipoblast, and you can also notice chicken wire vascular spaces. **Pleomorphic Liposarcoma, Pleomorphic lipoblasts are abundant

10 Fibrous Tumors & Reactive Proliferations: 1- Nodular fasciitis: reactive lesion Fasciitis: inflammation of the fascia, although it is a proliferative lesion. Morphology: Reactive fibroblastic proliferation frequently misdiagnosed as sarcoma, because it is rapid in proliferation and can show numerous mitoses Mostly affects young adults and presents as rapidly enlarging sometimes painful mass. Location: subcutaneous fat, dermis, in or below the fascia in the muscle Many have history of local trauma. Self-limiting. Whether you choose to excise it or not it causes no harm. Similar reactive lesion in muscle is Myositis Ossificans, contains bone. ** Myositis Ossificans: a form of nodular fasciitis that happens in the muscles and involves ossification 'bone formation'. Grossly: Unencapsulated < 3 cm mass in subcutaneous tissue, fascia or muscle. Micro: immature appearing fibroblasts with numerous mitoses, but no pleomorphism, with a myxoid background. Myxoid background, spindle and stellate fibroblasts, numerous mitosis (doesn't always indicate malignancy).

11 2- Fibromatosis: A group of fibroblastic proliferations Grow in an infiltrative fashion, but in superficial cases it is well circumscribed ** (nodular fasciitis: well circumscribed but not necessarily encapsulated) Recur after surgical excision but do not metastasize (deep cases) Various age groups Various types Two types: Superficial: Palmar (Dupuytren s contracture) in which it fixes one or more of the finger forward by developing a fibrous connection between the tendon and the skin. It can also occur in the plantar aspect of foot or on the penis. Deep: called Desmoid tumors: Arise in the abdominal wall Inside the abdomen Muscles of trunk and extremities Tend to be more aggressive Could be single or multiple Could happen as part of Gardner syndrome; APC/B-Catenin pathway abnormality. Dupuytren s contracture: patient can't extend finger well

12 Desmoid tumor: infiltrative; you can see spindle cells infiltrating the muscle and the fat. Fibromatosis is locally aggressive especially if it was deep seated, but it does not metastasize. 3-Fibrosarcoma: Malignant form of fibrous lesions. Mostly affects adults Sites: Deep soft tissues (thighs), knees and retroperitoneum. They tend to grow slowly. Gross: solitary, infiltrative or well-circumscribed. Micro: Fasicles of fibroblasts arranged in herringbone pattern Recurrence and metastatic rates depend on the grade. **as the grade goes higher the risk of metastasis goes up**

13 Its pattern resembles the way bones of fish are assembled. Fibrosarcoma / Herringbone pattern: Histological pattern.

14 Fibrohistiocytic Tumors: Several types Benign, borderline & malignant Mostly occurs in adults Usually benign in superficial lesions. Deep lesions are often malignant, larger, highly pleomorphic and can metastasize. Treatment is by excision Examples: Benign Fibrous Histiocytoma (Dermatofibroma): Common tumor Occurs in the dermis hence its name. Circumscribed tumor in the dermis or in subcutaneous tissue usually < 1 cm. Histology: lesion composed of Spindle cells & histiocytes Dermatofibrosarcoma Protruberance: (DFSP) Borderline malignant lesion As the above, it also occurs in the dermis and subcutaneous fat, but is larger and deeper. Infiltrative in nature, Mitoses is present and the tumor cells (fibrospindle cells) are CD34 positive. (CD34: vascular endothelial marker) Testing for this marker helps us to differentiate between the benign and malignant lesions of fibrohistiocytic origin. Recurs after excision Pleomorphic undifferentiated sarcoma Tumors of Smooth Muscle: Benign: Leiomyoma, mainly occurs in the uterus but could arise from vascular smooth muscles also. Malignant: Leiomyosarcoma (10-20% of STS) Also arises from the uterus or soft tissue. Better prognosis when superficial (easier to detect than deep) Large and deep lesions found in extremities or in retroperitoneum.

15 Tumors of Skeletal Muscle Almost all are malignant Rhabdomyosarcoma: Most common sarcoma of children, adolescents & young adults. (Important) Associated with chromosomal translocation t (2; 13) that produces a fusion gene PAX3-FKHR controlling muscle differentiation (alveolar type) Sites: Soft tissue, head & neck, genito-urinary tract Aggressive tumor Types: Embryonal: most common type mainly in head & neck, genitourinary & retroperitoneum. Alveolar: in extremities of adolescent Pleomorphic: usually in the deep soft tissues of adults. All three types are +ve for: Desmin, Myogenin & MYOD-1. Diagnostic cell is the Rhabdomyoblast which is Tadpole or Strap cell Prognosis worsens in this order: Embryonal pleomorphic alveolar **Desmin: intermediate fibers seen within the cytoplasm, aid in the differentiation of muscles regardless of their type (not specific for skeletal muscles) Myogenin & MYOD-1 (specific markers for skeletal muscles) so they will stain the nuclei of skeletal muscle fibers but will come back negative for smooth muscles.

16 You can notice Spindle cells in loose myxoid stroma, microphages and more primitive cells which are small round blue cells in this example. In the examples below you can notice an abundance of Rhabdomyoblasts (strap cells) in which some show cross striation 'maturation' Distinctive pink cytoplasms Round blue cells that are an indicative of: Ewing's Sarcoma, in this case if you suspect Rhabdomyosarcoma, test for Desmin, Myogenin & MYOD-1, if possitive then rhabdomyo. If for any reason you couldn't make a verdict after testing, you should test for genes associated in translocation.

17

18 SYNOVIAL SARCOMA Cell of origin is unknown Occurs in ages yrs. 10% of STS. Most are in deep soft tissue, adjacent to joints (Knee commonest) Rarely intra-articular (<10%) Specific translocation: t(x;18) fusion gene involved in transcription and the proliferation of tumor cells The name of this Sarcoma indicates that it occurs inside joints, but it actually doesn't except in rare cases. Morphology: Produces a mass, usually in the deep soft tissue Histologic findings: Biphasic (can show dual cell population which are spindle and epithelial structures) or monophasic (only spindle) it rarely only consists of epithelial structures. +ve for CK (cytokeratin epithelial marker) EMA (epithelial membrane antigen marker) ** It is a sarcoma but it is positive for epithelial markers which helps us to differentiate it from other sarcomas** Aggressively treated with limb-sparing surgery and chemotherapy Metastasizes through the blood to the lungs and bone, through lymphatic to the lymph nodes (sarcomas usually only metastasize through blood, but here it takes both routes of metastasis, blood and lymph) 5 year survival rate: 25-62%. But only 10-30% live > 10 yrs.

19 Biphasic synovial Sarcoma: You can see spindle stromal cells and epithelial elements forming gland like structures.

Tumors of Adipose Tissue Tumors Epidemiology Clinical Features. Morphology. Mature Adipocytes Separated by delicate fibrous septa

Tumors of Adipose Tissue Tumors Epidemiology Clinical Features. Morphology. Mature Adipocytes Separated by delicate fibrous septa Tumors of Adipose Tissue Lipoma Liposarcoma Most commonly happens in female The most common soft tissue tumor o Originates from matured Adipocytes Most commonly happes at the 4 th and 5 th decade of life

More information

أملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5

أملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5 Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs

More information

Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology

Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory

More information

Contents Part I Introduction 1 General Description 2 Natural History: Importance of Size, Site, Histopathology

Contents Part I Introduction 1 General Description 2 Natural History: Importance of Size, Site, Histopathology Contents Part I Introduction 1 General Description... 3 1.1 Introduction... 3 1.2 Incidence and Prevalence... 5 1.3 Predisposing and Genetic Factors... 8 References... 16 2 Natural History: Importance

More information

3/27/2017. Disclosure of Relevant Financial Relationships

3/27/2017. Disclosure of Relevant Financial Relationships Ophthalmic Pathology Evening Specialty Conference USCAP 2017 5 th March, 2017 Mukul K. Divatia, MD Assistant Professor Department of Pathology & Genomic Medicine Weill Cornell Medical College Houston Methodist

More information

Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON

Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma

More information

Soft Tissue Sarcomas: Questions and Answers

Soft Tissue Sarcomas: Questions and Answers Soft Tissue Sarcomas: Questions and Answers 1. What is soft tissue? The term soft tissue refers to tissues that connect, support, or surround other structures and organs of the body. Soft tissue includes

More information

Malignant Peripheral Nerve Sheath Tumor

Malignant Peripheral Nerve Sheath Tumor C H A P T E R 120 Malignant Peripheral Nerve Sheath Tumor Currently, malignant peripheral nerve sheath tumor (MPNST) is the most commonly used generic name for the neoplasms known in the past as neurosarcoma,

More information

Rhabdomyomas and Rhabdomyosarcomas (RMS) David M. Parham, MD Chief of Anatomic Pathology

Rhabdomyomas and Rhabdomyosarcomas (RMS) David M. Parham, MD Chief of Anatomic Pathology Rhabdomyomas and Rhabdomyosarcomas (RMS) David M. Parham, MD Chief of Anatomic Pathology Tumors of skeletal muscle: Rhabdomyomas and rhabdomyosarcomas Embryonal muscle 2 3 4 5 6 7 8 Rhabdomyoma Benign

More information

Spindle Cell Lesions Of The Breast. Emad Rakha Professor of Breast Pathology and Consultant Pathologist

Spindle Cell Lesions Of The Breast. Emad Rakha Professor of Breast Pathology and Consultant Pathologist Spindle Cell Lesions Of The Breast Emad Rakha Professor of Breast Pathology and Consultant Pathologist * SCLs comprise a wide spectrum of diseases, ranging from reactive processes to aggressive malignant

More information

Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis

Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN folpe.andrew@mayo.edu 2016 MFMER slide-1

More information

IN THE NAME OF GOD Dr. Kheirandish Oral and maxillofacial pathology

IN THE NAME OF GOD Dr. Kheirandish Oral and maxillofacial pathology IN THE NAME OF GOD Dr. Kheirandish Oral and maxillofacial pathology ORAL FOCAL MUCINOSIS Uncommon Tumorlike Cutaneous myxoid cyst Overproduction of hyaluronic acid by firoblasts Young adults Female Gingiva

More information

Musculoskeletal Sarcomas

Musculoskeletal Sarcomas Musculoskeletal Sarcomas Robert C. Orth, M.D., Ph.D. Edward B. Singleton Department of Pediatric Radiology Texas Children s Hospital Page 0 xxx00.#####.ppt 9/23/2012 9:01:18 AM No disclosures Page 1 xxx00.#####.ppt

More information

PLEOMORPHIC ADENOMA ( BENIGN MIXED TUMOR )

PLEOMORPHIC ADENOMA ( BENIGN MIXED TUMOR ) ( BENIGN MIXED TUMOR ) Grossly, the tumor is freely movable, solid, sometimes lobulated and occasionally cystic. If recurrent, multinodular masses are common. Histologically, within a fibrous capsule,

More information

Desmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC

Desmoplastic Melanoma R/O BCC. Clinical Information. 74 y.o. man with lesion on left side of neck r/o BCC R/O BCC Sabine Kohler, M.D. Professor of Pathology and Dermatology Dermatopathology Service Stanford University School of Medicine Clinical Information 74 y.o. man with lesion on left side of neck r/o

More information

57th Annual HSCP Spring Symposium 4/16/2016

57th Annual HSCP Spring Symposium 4/16/2016 An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no

More information

* I have no disclosures or any

* I have no disclosures or any Howard Rosenthal, M.D. Associate Professor of Orthopedic Surgery University of Kansas Sarcoma Center I have no disclosures or any conflicts related to the content of this presentation. Objectives 1. Describe

More information

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques

More information

number Done by Corrected by Doctor Maha Shomaf

number Done by Corrected by Doctor Maha Shomaf number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation

More information

The Relevance of Cytologic Atypia in Cutaneous Neural Tumors

The Relevance of Cytologic Atypia in Cutaneous Neural Tumors The Relevance of Cytologic Atypia in Cutaneous Neural Tumors Recent Findings - New Developments New Problems Zsolt B. Argenyi, M.D. Professor of Pathology & Dermatology Director of Dermatopathology Department

More information

Grading of Bone Tumors

Grading of Bone Tumors Grading of Bone Tumors Joon Hyuk Choi, M.D. Department of Pathology College of Medicine, Yeungnam University Introduction to grading system of bone tumor used at Mayo Clinic WHO Histologic Classification

More information

Special slide seminar

Special slide seminar Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance

More information

Aspen conference on pediatric disease. July through August Bone and Soft Tissue Update. David M. Parham, MD. Rhabdomyoma and rhabdomyosarcoma

Aspen conference on pediatric disease. July through August Bone and Soft Tissue Update. David M. Parham, MD. Rhabdomyoma and rhabdomyosarcoma Aspen conference on pediatric disease July through August 2014 Bone and Soft Tissue Update David M. Parham, MD Rhabdomyoma and rhabdomyosarcoma Embryonic rhabdomyogenesis is a highly conserved process

More information

Update On Lipomatous Tumors: Old Standbys and New Concepts

Update On Lipomatous Tumors: Old Standbys and New Concepts Update On Lipomatous Tumors: Old Standbys and New Concepts John R. Goldblum, M.D. Chairman, Department of Anatomic Pathology Cleveland Clinic Professor of Pathology Cleveland Clinic Lerner College of Medicine

More information

Financial disclosures

Financial disclosures An update on immunohistochemical markers in mesenchymal neoplasms By Konstantinos Linos MD, FCAP, FASDP Assistant Professor of Pathology Geisel School of Medicine at Dartmouth Dartmouth-Hitchcock Medical

More information

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture Neoplasia part I By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 2 nd Lecture Lecture outline Review of structure & function. Basic definitions. Classification of neoplasms. Morphologic features.

More information

Klinisch belang van chromosomale translocatie detectie in sarcomen

Klinisch belang van chromosomale translocatie detectie in sarcomen Translocations in sarcomas Klinisch belang van chromosomale translocatie detectie in sarcomen Judith V.M.G. Bovée, M.D., Ph.D. Department of Pathology Leiden University Medical Center RNA binding DNA binding

More information

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction

Disclosures. An update on ancillary techniques in the diagnosis of soft tissue tumors. Ancillary techniques. Introduction Disclosures An update on ancillary techniques in the diagnosis of soft tissue tumors. I have nothing to disclose. Andrew Horvai, MD, PhD Clinical Professor, Pathology Introduction Ancillary techniques

More information

Newer soft tissue entities

Newer soft tissue entities Newer soft tissue entities Examples among fibroblastic tumors Turku, May 6, 2010 Markku Miettinen, M.D. AFIP, Washington, DC Fibroblastic neoplasms Solitary fibrous tumor /Hemangiopericytoma Low-grade

More information

Neoplasia literally means "new growth.

Neoplasia literally means new growth. NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the

More information

Update on Cutaneous Mesenchymal Tumors. Thomas Brenn

Update on Cutaneous Mesenchymal Tumors. Thomas Brenn Update on Cutaneous Mesenchymal Tumors Thomas Brenn Cutaneous Mesenchymal Tumours Wide morphological and biological spectrum Myofibroblastic, smooth muscle, neural, vascular, apidocytic, undifferentiated;

More information

Introduction to Musculoskeletal Tumors. James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon

Introduction to Musculoskeletal Tumors. James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon Introduction to Musculoskeletal Tumors James C. Wittig, MD Orthopedic Oncologist Sarcoma Surgeon www.tumorsurgery.org Definitions Primary Bone / Soft tissue tumors Mesenchymally derived tumors (Mesodermal)

More information

Mayo Medical Laboratories

Mayo Medical Laboratories Mayo Medical Laboratories Virtual Lectures 2014 MFMER 2016 MFMER slide-1 Virtual Lectures Planning Committee Disclosure Summary As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo

More information

Neoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath

Neoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand

More information

A 25 year old female with a palpable mass in the right lower quadrant of her abdomen

A 25 year old female with a palpable mass in the right lower quadrant of her abdomen May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and

More information

Enterprise Interest Nothing to declare

Enterprise Interest Nothing to declare Enterprise Interest Nothing to declare Diagnoses one would not like to miss in soft tissue pathology early in your career Marta Sbaraglia, MD Department of Pathology Hospital of Treviso University of Padua

More information

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, 2008 9:30am - 11:30am FACULTY COPY GOAL: Describe the basic morphologic (structural) changes which occur in various pathologic conditions.

More information

Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement

Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center

More information

1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma

1/10/2018. Soft Tissue Tumors Showing Melanocytic Differentiation. Overview. Desmoplastic/ Spindle Cell Melanoma 2016 MFMER slide-1 2016 MFMER slide-2 2016 MFMER slide-3 Soft Tissue Tumors Showing Melanocytic Differentiation Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester,

More information

Classification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al.

Classification (1) Classification (3) Classification (2) Spindle cell lesions. Spindle cell lesions of bladder (Mills et al. Non-epithelial tumours and nonepithelial tumour-like lesions of the bladder Dr Jonathan H Shanks The Christie NHS Foundation Trust, Manchester, UK Classification (1) Myofibroblastic proliferations and

More information

Fun with Fat. General Rules. Case

Fun with Fat. General Rules. Case Fun with Fat General Rules Imaging: location (deep vs. superficial) Superficial lesions are seldom liposarcomas Deep lesions may be benign or malignant Myxoid stroma is common in benign and malignant lesions

More information

Update on Sarcomas of the Head and Neck. Kevin Harrington

Update on Sarcomas of the Head and Neck. Kevin Harrington Update on Sarcomas of the Head and Neck Kevin Harrington Overview Classification and incidence of sarcomas Clinical presentation Challenges to treatment Management approaches Prognostic factors Radiation-induced

More information

Prognostic Significance of Grading and Staging Systems using MIB-1 Score in Adult Patients with Soft Tissue Sarcoma of the Extremities and Trunk

Prognostic Significance of Grading and Staging Systems using MIB-1 Score in Adult Patients with Soft Tissue Sarcoma of the Extremities and Trunk 843 Prognostic Significance of Grading and Staging Systems using MIB-1 Score in Adult Patients with Soft Tissue Sarcoma of the Extremities and Trunk Tadashi Hasegawa, M.D. 1 Seiichiro Yamamoto, Ph.D. 2

More information

Part 1. Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013

Part 1. Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013 Part 1 Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013 Pediatric Pathology Soft Tissue Tumors AN UPDATE Rita Alaggio Azienda Ospedaliera Università di Padova Soft Tissue Tumors More

More information

INDEX. in this web service Cambridge University Press

INDEX. in this web service Cambridge University Press actin 14 adamantinoma 202, 290 292, 297 adenocarcinoma 136 adipocytes in hibernoma 149, 150 in lipoblastoma 148 in lipoma 141, 142, 145 in liposarcoma 152 in myelolipoma 151 adrenal gland tumors see myelolipoma

More information

Gross appearance of peritoneal cysts. They have a thin, translucent wall and contain a clear fluid.

Gross appearance of peritoneal cysts. They have a thin, translucent wall and contain a clear fluid. Gross appearance of peritoneal cysts. They have a thin, translucent wall and contain a clear fluid. So-called multicystic benign mesothelioma. A, Gross appearance. So-called multicystic benign mesothelioma.

More information

Histopathological Pattern of Soft Tissue Tumours in 200 Cases.

Histopathological Pattern of Soft Tissue Tumours in 200 Cases. DOI: 10.21276/aimdr.2016.2.6.PT2 Original Article ISSN (O):2395-2822; ISSN (P):2395-2814 Histopathological Pattern of Soft Tissue Tumours in 200 Cases. Singh Harpal 1, Richika 2, Kundal Ramesh 3 1 Associate

More information

Financial disclosures

Financial disclosures Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchc Geisel School of

More information

Financial disclosures

Financial disclosures Mesenchymal Neoplasms with Melanocytic Differentiation By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel

More information

PROBLEMS OF PROGNOSTICATION IN SOFT TISSUE TUMOURS. Christopher D.M. Fletcher Brigham and Women s Hospital and Harvard Medical School Boston, MA

PROBLEMS OF PROGNOSTICATION IN SOFT TISSUE TUMOURS. Christopher D.M. Fletcher Brigham and Women s Hospital and Harvard Medical School Boston, MA PROBLEMS OF PROGNOSTICATION IN SOFT TISSUE TUMOURS Christopher D.M. Fletcher Brigham and Women s Hospital and Harvard Medical School Boston, MA Dr. Fletcher has no conflict of interest or disclosures to

More information

ACCME/Disclosures ALK FUSION-POSITIVE MESENCHYMAL TUMORS. Tumor types with ALK rearrangements. Anaplastic Lymphoma Kinase. Jason L.

ACCME/Disclosures ALK FUSION-POSITIVE MESENCHYMAL TUMORS. Tumor types with ALK rearrangements. Anaplastic Lymphoma Kinase. Jason L. Companion Meeting of the International Society of Bone and Soft Tissue Pathology The Evolving Concept of Mesenchymal Tumors ALK FUSION-POSITIVE MESENCHYMAL TUMORS Jason L. Hornick, MD, PhD March 13, 2016

More information

Case 8 Soft tissue swelling

Case 8 Soft tissue swelling Case 8 Soft tissue swelling 26-year-old female presented with a swelling on the back of the left knee joint since the last 6 months and chronic pain in the calf and foot since the last 2 months. Pain in

More information

21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells

21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells UPDATE IN CUTANEOUS VASCULAR S DERMATOPATHOLOGY SESSION BELFAST PATHOLOGY JUNE 21/2017 Dr E Calonje St John s Institute of Dermatology, London, United Kingdom THE FAMILY OF VASCULAR S WITH EPITHELIOID

More information

Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors

Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors Original Article DOI: 10.21276/APALM.1637 Diagnostic Value of Immunohistochemistry in Soft Tissue Tumors Sridevi. V*., Susruthan Muralitharan., and Thanka. J Dept of Pathology, SriMuthukumaran Medical

More information

SOFT TISSUE TUMOR PATHOLOGY: AN UPDATE

SOFT TISSUE TUMOR PATHOLOGY: AN UPDATE SOFT TISSUE TUMOR PATHOLOGY: AN UPDATE Jason L. Hornick, MD, PhD July 18, 2013 Department of Pathology Brigham and Women s Hospital Harvard Medical School Boston, MA, USA I have no disclosures. New Soft

More information

Myxo-inflammatory Fibroblastic sarcoma

Myxo-inflammatory Fibroblastic sarcoma AKA Myxo-inflammatory Fibroblastic sarcoma Acral Myxoinflammatory fibroblastic sarcomaam.j.surg.path1998; 22; 911-924 Inflammatory myxoid tumour of soft parts with bizarre giant cells [Pathol.Res.Pract.

More information

Diagnostic Approach to Soft Tissue Tumors

Diagnostic Approach to Soft Tissue Tumors SECTION 2 Diagnostic Approach to Soft Tissue Tumors Overview Biopsy and Resection of Soft Tissue Tumors 20 Clinical Approach Age- and Location-Based Approach to Diagnosis 24 Histologic Approach Pattern-Based

More information

Table 1 Histiogenic Classification and Metastatic Potential of Canine Soft Tissue Sarcomas Tissue of Origin Benign Malignant Primary Sites

Table 1 Histiogenic Classification and Metastatic Potential of Canine Soft Tissue Sarcomas Tissue of Origin Benign Malignant Primary Sites Soft Tissue Sarcomas Incidence and Risk Factors Soft tissue sarcomas are a heterogeneous population of mesenchymal tumours representing 15% of skin and subcutaneous tumours in the dog and 7% in the cat.

More information

A neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after

A neoplasm is defined as an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a

More information

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D.

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D. NEOPLASIA-I CANCER Nam Deuk Kim, Ph.D. 1 2 Tumor in the hieroglyphics of the Edwin Smith papyrus (1,600 B.C., Breasted s translation 1930) 3 War on Cancer (National Cancer Act, 1971) 4 Cancer Acts in Korea

More information

DUSTURBANCES OF GROWTH. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa

DUSTURBANCES OF GROWTH. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa DUSTURBANCES OF GROWTH MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L8 Uz: Musa Agnesia: means complete absence of an organ (Kidney). Aplasia: s defined in general as "defective development

More information

An Overview of Genital Stromal Tumors

An Overview of Genital Stromal Tumors An Overview of Genital Stromal Tumors By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel School of Medicine

More information

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD

Immunohistochemistry in Bone and Soft Tissue Tumors. Sahar Rassi Zankoul, MD Immunohistochemistry in Bone and Soft Tissue Tumors Sahar Rassi Zankoul, MD Introduction Bone tumors represent a wide variety of tumors of various origins and malignant potentials. These different tumor

More information

Note: The cause of testicular neoplasms remains unknown

Note: The cause of testicular neoplasms remains unknown - In the 15- to 34-year-old age group, they are the most common tumors of men. - Tumors of the testis are a heterogeneous group of neoplasms that include: I. Germ cell tumors : 95%; all are malignant.

More information

Slide Seminar Spanish Society of Pathology

Slide Seminar Spanish Society of Pathology Slide Seminar Spanish Society of Pathology John R. Goldblum, M.D. Chairman, Department of Anatomic Pathology Cleveland Clinic Professor of Pathology Cleveland Clinic Lerner College of Medicine 1921 Original

More information

Surgical Pathology Evening Specialty Conference USCAP 2015

Surgical Pathology Evening Specialty Conference USCAP 2015 Surgical Pathology Evening Specialty Conference USCAP 2015 John R. Goldblum, M.D. Chairman, Department of Pathology, Cleveland Clinic Professor of Pathology, Cleveland Clinic Lerner College of Medicine

More information

Pediatric Soft-Tissue Sarcomas. Beth McCarville, MD St. Jude Children s Research Hospital Memphis, Tn

Pediatric Soft-Tissue Sarcomas. Beth McCarville, MD St. Jude Children s Research Hospital Memphis, Tn Pediatric Soft-Tissue Sarcomas Beth McCarville, MD St. Jude Children s Research Hospital Memphis, Tn Overview Histologic classifications Characteristic imaging features Helpful clinical characteristics

More information

BREAST PATHOLOGY. Fibrocystic Changes

BREAST PATHOLOGY. Fibrocystic Changes BREAST PATHOLOGY Lesions of the breast are very common, and they present as palpable, sometimes painful, nodules or masses. Most of these lesions are benign. Breast cancer is the 2 nd most common cause

More information

ASCP Resident Review Mini-Course Series Session 2: Renal and Soft Tissue Pathology. Carole Vogler MD, FASCP Ema Dragoescu MD

ASCP Resident Review Mini-Course Series Session 2: Renal and Soft Tissue Pathology. Carole Vogler MD, FASCP Ema Dragoescu MD 178 2011 ASCP Resident Review Mini-Course Series Session 2: Renal and Soft Tissue Pathology Carole Vogler MD, FASCP Ema Dragoescu MD 2011 Annual Meeting Las Vegas, NV AMERICAN SOCIETY FOR CLINICAL PATHOLOGY

More information

-The cause of testicular neoplasms remains unknown

-The cause of testicular neoplasms remains unknown - In the 15- to 34-year-old age group, they are the most common tumors of men. - include: I. Germ cell tumors : (95%); all are malignant. II. Sex cord-stromal tumors: from Sertoli or Leydig cells; usually

More information

Cellular Neurothekeoma

Cellular Neurothekeoma Cellular Neurothekeoma Scott W Binder, MD Pritzker Professor of Pathology & Dermatology Sr. Vice Chair Director, Pathology Clinical Services Chief, Dermatopathology Geffen/UCLA School of Medicine Clinical

More information

USCAP Pediatrics Evening Subspecialty Conference 2015

USCAP Pediatrics Evening Subspecialty Conference 2015 USCAP Pediatrics Evening Subspecialty Conference 2015 Sunday 22 March 2015 Alexander Lazar MD/PhD Department of Pathology S Section of Bone Soft TIssue Pathology Sarcoma Research Center The Case Patient

More information

General: Brain tumors are lesions that have mass effect distorting the normal tissue and often result in increased intracranial pressure.

General: Brain tumors are lesions that have mass effect distorting the normal tissue and often result in increased intracranial pressure. 1 Lecture Objectives Know the histologic features of the most common tumors of the CNS. Know the differences in behavior of the different tumor types. Be aware of the treatment modalities in the various

More information

ACCME/Disclosures. Everything is spindle - how far can we go with limited FNA material? Everything is spindle how far can we go? Everything is spindle

ACCME/Disclosures. Everything is spindle - how far can we go with limited FNA material? Everything is spindle how far can we go? Everything is spindle ACCME/Disclosures The USCAP requires that anyone in a position to influence or control the content of CME disclose any relevant financial relationship WITH COMMERCIAL INTERESTS which they or their spouse/partner

More information

GUT-C 11/30/2017. Debasmita Das, M.D. PGY-1 Danbury Hospital

GUT-C 11/30/2017. Debasmita Das, M.D. PGY-1 Danbury Hospital GUT-C 11/30/2017 Debasmita Das, M.D. PGY-1 Danbury Hospital CLINICAL SUMMARY 8/2017 59 year old female Presented to the ED with 1 month history of general malaise, fever and weight loss PMH: Significant

More information

Lung Tumor Cases: Common Problems and Helpful Hints

Lung Tumor Cases: Common Problems and Helpful Hints Lung Tumor Cases: Common Problems and Helpful Hints Brandon T. Larsen, MD, PhD Senior Associate Consultant Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Arizona Society of Pathologists

More information

WHO Classification of Soft Tissue Tumours

WHO Classification of Soft Tissue Tumours WHO Classification of Soft Tissue Tumours This new WHO classification of soft tissue tumours, in line with other volumes in this new series, incorporates detailed clinical, histological and genetic data.

More information

Pathology Mystery and Surprise

Pathology Mystery and Surprise Pathology Mystery and Surprise Tim Smith, MD Director Anatomic Pathology Medical University of South Carolina Disclosures No conflicts to declare Some problem cases Kidney tumor Scalp tumor Bladder tumor

More information

Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell

Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell Primary bone tumors > metastases from other sites Primary bone tumors widely range -from benign to malignant. Classified according to the normal cell counterpart and line of differentiation. Among the

More information

MVST BOD & NST PART IB Thurs. 2 nd & Fri. 3 rd March 2017 Pathology Practical Class 23

MVST BOD & NST PART IB Thurs. 2 nd & Fri. 3 rd March 2017 Pathology Practical Class 23 MVST BOD & NST PART IB Thurs. 2 nd & Fri. 3 rd March 2017 Pathology Practical Class 23 Neoplasia I Neoplasia I: Benign and malignant neoplasms in glandular epithelium and mesenchyme 1.0. Aims 1. To understand

More information

Q&A. Fabulous Prizes. Collecting Cancer Data: Bone and Soft Tissue 1/10/113. NAACCR Webinar Series

Q&A. Fabulous Prizes. Collecting Cancer Data: Bone and Soft Tissue 1/10/113. NAACCR Webinar Series Collecting Cancer Data Bone & Soft Tissue NAACCR 2012 2013 Webinar Series Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this

More information

Diagnostic Cytology of Cancer Cases

Diagnostic Cytology of Cancer Cases Diagnostic Cytology of Cancer Cases Somporn Techangamsuwan Companion Animal Cancer Research Unit (CAC-RU) Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University 1 Tumor or Non-tumor

More information

Gastrointestinal stromal tumor

Gastrointestinal stromal tumor Gastrointestinal stromal tumor 영남의대병리학교실 최준혁 Classification of gastrointestinal mesenchymal tumor Gastrointestinal stromal tumor(gist) Smooth muscle tumors : leiomyoma, leiomyosarcoma Neurogenic tumors

More information

Chondroid lipoma: A rare recently described benign lipomatous tumor

Chondroid lipoma: A rare recently described benign lipomatous tumor Al-Malki et al. 7 case report peer Reviewed open OPEN ACCESS Chondroid lipoma: A rare recently described benign lipomatous tumor Salman T. Al-Malki, Abdullah S. Al-Khamiss Abstract Introduction: lipomatous

More information

Differential Diagnosis of Oral Masses. Palatal Lesions

Differential Diagnosis of Oral Masses. Palatal Lesions Differential Diagnosis of Oral Masses Palatal Lesions Palatal Masses Periapical Abscess Torus Palatinus Mucocele Lymphoid Hyperplasia Adenomatous Hyperplasia Benign Salivary Neoplasms Malignant Salivary

More information

Evening Specialty Conference Bone and Soft Tissue Pathology. Diagnostic pitfalls in bone and soft tissue pathology

Evening Specialty Conference Bone and Soft Tissue Pathology. Diagnostic pitfalls in bone and soft tissue pathology Evening Specialty Conference Bone and Soft Tissue Pathology. Case 1 Elizabeth G Demicco, MD, PhD Mount Sinai Hospital, New York Disclosure of Relevant Financial Relationships USCAP requires that all planners

More information

Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes

Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes Sarcoma Volume 2015, Article ID 740571, 5 pages http://dx.doi.org/10.1155/2015/740571 Research Article A Clinicopathological Analysis of Soft Tissue Sarcoma with Telangiectatic Changes Hiroshi Kobayashi,

More information

Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden. Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4

Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden. Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4 Scandinavian Sarcoma Group and Oncologic Center, Lund, Sweden Centralized Registration of Sarcoma Patients in Scandinavia SSG VII:4 Modified April, 2009 Scandinavian Sarcoma Group & Oncologic Center, Lund,

More information

LAC + USC.

LAC + USC. Jeff McDavit,, M.D. LAC + USC mcdavit@usc.edu Clinical History 55 year old male with large, deep, non- tender left thigh mass. Seen at LAC+USC Med Ctr FNA clinic No h/o trauma or radiation Vimentin

More information

A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1

A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 1 Animal Health Trust, Newmarket, UK 2 608 Equine and Farm Vets, Rowington, UK Signalment: Horse,

More information

Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case.

Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case. ISPUB.COM The Internet Journal of Pathology Volume 10 Number 1 Atypical Palisaded Myofibroblastoma of Lymph Node: Report of a rare case. V Kinnera, R Nandyala, M Yootla, K Mandyam Citation V Kinnera, R

More information

Conceptual Evolution of Soft Tissue Tumors Classification

Conceptual Evolution of Soft Tissue Tumors Classification Conceptual Evolution of Soft Tissue Tumors Classification Angelo P. Dei Tos M.D. Departments of Pathology & Oncology Treviso, Italy How WHO classification was reshaped Pathologists and Cytogeneticists

More information

Case 1. Disclosure. Imaging. Clinical history 5/10/2016. USCAP 2016 Annual Meeting Evening Specialty Conference Bone and Soft tissue Pathology

Case 1. Disclosure. Imaging. Clinical history 5/10/2016. USCAP 2016 Annual Meeting Evening Specialty Conference Bone and Soft tissue Pathology Disclosure Dr. Agaram has nothing to disclose Case 1 Narsi Agaram, MBBS USCAP 2016 Annual Meeting Evening Specialty Conference Bone and Soft tissue Pathology Clinical history Imaging 1998 A three month

More information

From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology. Songlin Zhang, MD, PhD LSUHSC-Shreveport

From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology. Songlin Zhang, MD, PhD LSUHSC-Shreveport From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology Songlin Zhang, MD, PhD LSUHSC-Shreveport I have no Conflict of Interest. FNA on Lymphoproliferative

More information

Index. J Juvenile hyaline fibromatosis, 27 Juvenile xanthogranuloma, 57 Juxta-articular myxoma, 152

Index. J Juvenile hyaline fibromatosis, 27 Juvenile xanthogranuloma, 57 Juxta-articular myxoma, 152 A Adenomatoid tumor, 76, 77 Adipose tissue tumors benign tumors angiolipoma, 6 chondroid lipoma, 9 fibrolipoma, 5 hibernoma, 8 lipoblastoma, 9 lipoma (see Lipoma) myelolipoma, 6 pleomorphic lipoma, 8 spindle

More information

Case 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset

Case 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or

More information

My Journey into the World of Salivary Gland Sebaceous Neoplasms

My Journey into the World of Salivary Gland Sebaceous Neoplasms My Journey into the World of Salivary Gland Sebaceous Neoplasms Douglas R. Gnepp Warren Alpert Medical School at Brown University Rhode Island Hospital Pathology Department Providence RI Asked to present

More information

Essential Dermatopathology. Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center

Essential Dermatopathology. Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center Essential Dermatopathology Jinah Kim, MD, PhD Department of Pathology and Dermatology Stanford University Medical Center OBJECTIVES Review clinical, pathologic and molecular aspects of bone and fat tumors

More information

Notice of Faculty Disclosure

Notice of Faculty Disclosure Mesenchymal Tumors of the Vulva: Old, New, Something(s) Different Napa Valley Conference Pathology Education Partners Inc May 15, 2018 Teri A. Longacre, M.D. longacre@stanford.edu Stanford University,

More information

DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV

DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV NEOPLASMS A) Epithelial I. Benign Pleomorphic adenoma( Mixed tumour) Adenolymphoma (Warthin s tumour) Oxyphil adenoma (Oncocytoma)

More information