SCIENTIFIC PROGRAMME SNOLA THE STATE OF THE ART ON NEURO-ONCOLOGY th March

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1 SCIENTIFIC PROGRAMME SNOLA THE STATE OF THE ART ON NEURO-ONCOLOGY th March 13h 13h45 ROOM 1 ROOM 2 ROOM 3 Imaging and pathology case discussion Lymphomas case discussion- Meningeomas Moderator: XXX experts: XXXX 13:30-13:35h Meeting expert (35 ) - Posterior fossa tumor 13h45 16h Advanced Imaging for CNS lymphomas 15 min Update of PETscan CT/MRI for CNS lymphomas challenges in lymphoma pathology and genetics Role of CSF analisys and liquid biopsy for lymphomas update in the diagnosis, risk factors and treatment of secondary CNS lymphomas Cavernous sinus anatomy review update of Pathology and genetics in meningeomas Correlation of Meningioma behavior and pathology with MRI imaging Surgical approaches for paraselar meningeomas Endoscopic approaches for paraselar and clivus meningiomas 13:35-14:05h Posterior fossa tumors: Radiology (15 ) and Pathology (15 ) interaction 14:10h - 14:55h Cerebellar mutism syndrome. Is it possible to avoid? (20 ) What are the consequences? Psico(10 )Fono(10 ) 15:00-15:30h Keynote Medulloblastoma in children and adolescentspresent and future (30 ) current role of radiotherapy for CNS lymphomas radiotherapy strategy for skull base meningiomas 15:30-15:45h Radiotherapy for medulloblastoma in the new era(15 )

2 State of art of primary CNS lymphoma treatment TRAMS Treatment Response Assessment Maps update on systemic treatment for recurrent meningiomas and chordomas The role of radiosurgery for meningeomas Discussion 15:50-16:10h 2x Oral Presentation (8 2 ) 16h15-16h45 16h45-17h05 17h05-17h25 17h25-17h45 17h45-18:30h Integrative treatment for meningeomas: from diagnosis to recurrence Integrative treatment for ependimomas: from diagnosis to recurrence Clinical integrative treatment of medulloblastoma in the molecular ERA FIRING SQUAD SESSION JUDGES: MODERATORS: Session on meningeomas Session on ependimomas Session on meduloblatomas

3 16th March 8h-8h40 ROOM 1 ROOM 2 ROOM 3 Imaging and pathology of chordomas discussion case discussion Eloquent area glioma Moderator: XXX experts: XXXX 8-8:35h case discussion: Pediatric craniopharyngioma 8h40-10h30 Imaging pitfills in chordoma diagnosis pathology and molecular markers for chordomas Palliative care approach in neurooncology Multidisciplinary approach for oncology pain 8:35-9:40h The role of treatment for craniopharyngioma: Surgery (10 ) systemic (10 ) or radiotherapy (10 ) Surgery for skull base chordomas Radiotherapy strategy for chordomas? Photons X protons Insular tumors classifications and surgical strategies Role of DTI and hot spot identification for radiotherapy planning Neuroendocrinological effects in craniopharyngioma: how we can deal with? (15 ) Ophthalmic evaluation in suprasellar lesionsalways necessary? (15 ) Questions (5 ) Systemic treatment options for chordomas The current role of PET-CT in brain tumors 9:40-10:20h Ependymoma: future perspectives in terms of treatment (20 ) Surgery and LITT for spinal chordomas Integrative treatment for malignant nerve sheath tumors How to define tumor progression X treatment effect Perpectives of nanotherapy in neurooncology Radiation therapy for ependymoma, is always necessary? (15 ) Perguntas(5 ) 10:20h-10:30h 1x Oral Presentation (8 2 ) Understanding NF1 and NF 2 patients:

4 from genetics to treatment 10h30-11h 11h-11h20 11h20-11h50 11h50-12h10 Perspectives of proton therapy for brain tumor Opening ceremony and awards Surgery for brain metastasis: the now and the next? 12h10-13h10 13h10-13h50 LUNCH ROOM 1 ROOM 2 Firing Squad Session on Spinal metastasis Moderators: XXX JUDGES: XXX Judged: XXX Oral presentations 7 min each 1 min reply Moderators: XXX 13:10-13:45h Keynote Low grade glioma in the new era (30') 13h50-16h30 imaging advances in intra-medular tumors BBB and drugs: myth or reality 13:45-14:35h Gliomas: Learning from the Radiology (15 ) Advances in intramedular tumor surgery BBB and immunotherapy: myth or reality and Pathology (15 ) perspectives State of art in compressive multiple mieloma treatment Role of ctdna and CTC in the CSF evaluation for gliomas Hypothalamic LGGwhen the surgery should be considered? (15 ) Questions(5 ) Surgical indication and technic for multiple mieloma fracture Cognitive evaluation in neuro-oncology: how useful is it? 14:35h 15:30h High-grade glioma: Are any lessons to learn from the adult world? (20 ) Role of radiotherapy in spinal cord tumor WBRT cognitive protection update Brainstem glioma: should we always biopsy? (15 ) State of art in Stereotectic When the disease

5 leptomeningeal disease treatment VHL: treatment options for hemangioblastomas. Systemic treatment for recurrent schwanomas and skull base sarcoma Single X Fractionated Radiosurgery Why surgery for acoustic schawanoma? Why radiosurgery for acoustic??? radiotherapy for recurrent gliomas LITT for gliomas: useful? Convection intratumoral therapy for gliomas: useful? State of art of Ultrasound in glioma surgery wins, how should we proceed? (15 ) 15:30-15:50h Choroid plexus tumors. How to conduct? (15 ) 15:50-16:10h Treating CNS tumors in low and middleincome countries. (15 ) Questions(5 ) 2x Oral Presentation (8 2 ) 16h30-17h 17h-17h20 17h20-17h40 17h40-18h 18h-18h20 18h20-18h30 20h TTF is the new standard of care for glioblastoma? Chemobrain and radiotherapy cognitive impairment for gliomas: How real is it? current standard of care for low grade gliomas Current role of extent of resection for gliomas in molecular era Discussion President s Dinner

6 17 th March ROOM 1 ROOM 2 ROOM 3 8h-8h40 case discussion Pituitary adenoma Moderators: XXX Experts: XXX Oral presentations Moderators: XXX 8:00-8:35h Keynote Radiotherapy avoiding treatment for young children (30 ) 8h40-10h20 Moderators: XXX Supraselar adenomas: when endoscopic surgery is not enough? MODERATORS: XXX How to achieve and measure gross total resection in gliomas 8:35-9:10h The Atypical theratoid/rabdoid tumors should be treated differently? (15 ) Clinical treatment for pituitary adenomas Adult brainstem intrinsic glioma: diagnosis pitfalls and current treatment, Embryonal tumors in the new classification, how should we conduct? (15 ) Radiosurgery pitfalls for pituitary adenomas EGFR analysis: should we do it? 9:10-9:30h Outcome measures in children with neuropsychological impairments after intensive treatment (15 ) Future directions of radiosurgery for pituitary adenomas Current role of MGMT analysis for low and high grade gliomas 9:30-9:50h Relapsed medulloblastoma is it possible to rescue? (15 ) Principles of CNS immunology? Promising molecular markers in gliomas 9:50h-10:20h Adaptive hybrid surgery Supratotal resection for GBM? 15 min Meeting expert- clinical case of ABMT 10h20-10h50

7 10h50-11h10 11h10-11h30 11h30-11h50 11h50-12h10 12h10-13h10 13h10-13h50 13h50-16h10 Massive genetic sequence in GBM: are we going anywhere? Perspectives in Immunotherapy for GBM State of art of 5-ALA guided surgery New perspectives of treatment for spinal metastasis LUNCH ROOM 1 ROOM 2 ROOM 3 Firing Squad session on Brain metastasis MODERATORS: Stratification for brain metastasis: still useful? Abscopal effect of radiotherapy and immunotherapy Current Integrative treatment for lung brain metastasis Current Integrative treatment for breast brain metastasis Oral presentations Moderators XXX MODERATORS: Pathology review for gliomas: why should we do it? When pathology does not match imaging: Neuroradiologist point of view 15 min When pathology does not match imaging: Neuropathologist point of view correlation between molecular markers and imaging 13:10-13:50h case discussion: Pineal region tumors or firing squad 13:50-14:25h Pineal tumors: Is it possible to make diagnosis by image? (15) Pineal tumors Pathology in and liquid biopsy, is it possible to make diagnosis? (15 ) 14:25-15:15h How should be conduct a pineal tumor lesion (pineal parenchyma tumor and embryonal) in terms of surgery. (15 ) When surgery is necessary for CNSGCT? (15 ) Current integrative treatment for melanoma brain metastasis Radiotherapy for eloquent brain metastasis Surgery for eloquent area brain metastasis Brain metastasis: when should palliative care be Low grade glioma recurrence: treatment options Current status of bevacizumab in HGG Reoperation in high grade gliomas: why do it? What should we do when GBM progress Is it possible to avoid RT in CNSGCT nowadays? (15 ) 15:15-15:40h Neurocognitive and Psychological functioning of patients after CNSGCT treatment (20 )

8 involved? Current status of radiosurgery for spinal metastasis 5 ala X imri: what is the best? after bevacizumab? current integrative treatment of GBM in elderly 15:40-16:10h 3x Oral Presentations 16h10-16h40 16h40-17h 17h-17h20 17h20-17h40 17h40-18h 18H-18H20 18h20-18h40 LITT for brain metastasis Protocol X personalized treatment in patients with brain metastasis? The role of radiosurgery to surgical bed in brain metastasis Is the hypo fractionated radiotherapy the future of LGG and HGG treatment? CNSGCT a multidisciplinary tumor Poster and oral presentation awards and MEETING ADJOURN (CLOSURE)