Five Years Comprehensive Experience in Proton Radiotherapy in PMRC Tsukuba
|
|
|
- Bernard Jenkins
- 5 years ago
- Views:
Transcription
1 PTCOG 47 Jacksonville, Florida Five Years Comprehensive Experience in Proton Radiotherapy in PMRC Tsukuba Koji Tsuboi M.D., Ph.D. Proton Medical Research Center, University of Tsukuba, JAPAN
2 Where is Tsukuba? Tsukuba Terminal Tsukuba Tsukuba Express Tokyo
3 Mt. Tsukuba and Tsukuba Science City
4 University Hospital of Tsukuba Proton Medical Research Center
5 Layout of the proton therapy facility
6 Cases treated at PMRC during the last 5 years ( ) * *
7 Cases treated at PMRC during the last 5 years ( ) 1024
8 Hepatocellular carcinoma (HCC) 1) 66 GyE / 10 fractions Solitary tumor 10 cm or less in diameter 2 cm away form the port hepatis or the GI tract Child-Pugh A or B 51 cases 2) 72.6GyE / 22 fractions Within 2 cm from the port hepatis 53 cases 3) 70.0 GyE / 35 fractions within 2 cm from the GI tract
9 26 y.o. man 66 GyE/10 fractions Pre-treatment 38 months later Planning
10 Local Control Rate of Patients Treated by 66 GyE/10 fractions 100 Local control rate (%) n = 51 3 years: 93.8 % 5 years: 83.3 % 0 Months
11 Overall Survival of Patients Treated by 66 GyE/10 fractions Overall survival rate (%) n = 51 MST: 35.0 months 3 years: 48.0 % 5 years: 35.2 % Months
12 Hepatocellular carcinoma (HCC) 1) 66 GyE / 10 fractions Solitary tumor 10 cm or less in diameter 2 cm away form the port hepatis or the GI tract Child-Pugh A or B 51 cases 2) 72.6GyE / 22 fractions Within 2 cm from the port hepatis 53 cases 3) 70.0 GyE / 35 fractions within 2 cm from the GI tract
13 Survival of cases with 72.6GyE/ 22 fractions n = 53 Local Control 3 year: 86% Percentage Overall Survival MST: 34 months 3 year: 45.1% 20 Progression-Free Survival MST: 14.4 months 3 year: 25.1% (months)
14 Overall survival of cases with 72.6GyE/ 22 fractions Survival rate Child-Pugh class A, single tumor, and AFP 100 n = 14 3 year: 83.9 % Child-Pugh class B or C, multiple tumors, or AFP 100 n = 39 3 year: 32.9 % (months)
15 A current clinical trials in HCC 1) Phase I-IIa trial of combination of proton radiotherapy and novel immunological adjuvant therapy Proton beam Proton beam HCC + Tumor Specific Immunotherapy Use of a novel adjuvant 2) Phase II clinical trial of proton radiotherapy for HCC with portal vein tumor thrombus. Tumor thrombus at the main portal vein and its first branches 72.6GyE / 22 fractions
16 Non-small cell lung cancers Stage I: 37 cases Phase II trial Peripheral: Tumors in the zone outside of the proximal bronchial tree : 24 cases CTV = GTV mm PTV = CTV mm 66GyE/ 10 fractions Proximal: Tumors in the zone of the proximal bronchial tree defined in RTOG cases CTV = GTV mm proximal PTV = CTV mm 72.6 GyE/22 fractions peripheral Stage II-III: 34 cases Retrospective analysis CTV1 = GTV1 (primary mm CTV2 = GTV2 (LN mm PTV= CTV1 + CTV mm
17 Local control of stage I peripheral type CR: /24 PR: /24 SD: 4.0 1/24 PD: 0 0/24
18 Progression free survival of stage I peripheral type Probability Months 1 year 2 years 3 years 4 years 94.7% 82.1% 73.0% 48.7%
19 Overall survival of stage I peripheral type Median observation time: 22.9 months Alive 23 Dead y.o. woman ct1nomo Died of NSCLC at 39.9 months
20 Non-small cell lung cancers Stage I: 37 cases Phase II clinical study Peripheral: Tumors in the zone outside of the proximal bronchial tree : 24 cases CTV = GTV mm PTV = CTV mm 66GyE/ 10 fractions Proximal: Tumors in the zone of the proximal bronchial tree defined in RTOG cases CTV = GTV mm proximal PTV = CTV mm 72.6 GyE/22 fractions peripheral Stage II-III: 34 cases Retrospective analysis CTV1 = GTV1 (primary mm CTV2 = GTV2 (LN mm PTV= CTV1 + CTV mm
21 Local control rate of stage I proximal type CR: /13 PR: /13 SD: 7.6 1/13 PD: 7.6 1/13
22 Progression free survival of stage I proximal type Probability 1 year 2 years 3 years Months
23 Overall survival of stage I proximal type Median observation time: 15.2 months Alive: 13 cases Dead: none
24 Non-small cell lung cancers Stage I: 37 cases Peripheral: Tumors in the zone outside of the proximal bronchial tree : 24 cases CTV = GTV mm PTV = CTV mm 66GyE/ 10 fractions Proximal: Tumors in the zone of the proximal bronchial tree defined in RTOG cases CTV = GTV mm PTV = CTV mm 72.6 GyE/22 fractions Stage II-III: 34 cases These patients did not underwent surgery and chemotherapy for some reasons. CTV1 = GTV1 (primary mm CTV2 = GTV2 (LN mm PTV= CTV1 + CTV mm
25 Prescribed doses to stage II-III (Retrospective analysis) 66 GyE/10 frac 3cases (α/β=3, 108 GyE) 72.6 GyE/22 frac 9 cases (α/β=3, 83.2 GyE) 77 GyE/35 frac 14 cses (α/β=3, 80.1 GyE) 83.6 GyE/38 frac 8 cases (α/β=3, 86.9 GyE)
26 Local control rate of stage II-III
27 Progression free survival of stage II-III MST: 16.4 months Probability Months 1 year 2 years 3 years 4 years 5 years No chemotherapy No surgery
28 A current clinical trials in NSCLC Phase I/II clinical trail of proton radiotherapy with concurrent chemotherapy for stage II, IIIA and IIIb NCSLC Dose escalation form 74GyE/37 frac to 78GyE/39 frac Concurrent administration of cisplatin and vinorelbine
29 Intracranial lesions Malignant gliomas Meningiomas Neurinomas AVM
30 Proton therapy for AVM in PMRC ( ) 33 cases, M/F =23/10, Age: 35.6 y.o. Treatment SRS: 28 cases SRT: 5 cases 2 frac: 2, 3 frac:2, 15 frac:1 Dose 17Gy-25Gy (Av. 22.5Gy 3 6 ports Results Complete cure 21 / 25 (75%) Decrease in size 3 / 25 (11%) No change 2 / 25 (7%) Enlargement 2 / 25 (7%) hemorrhage 1 / 25 (4%) Necrosis 2 / 25 (7%)
31 18 cases with AVM 3 cm at Tsukuba Modality Proton γ-knife Number 11 7 Re-bleeding 1 (9.1%) Cure after 3 years 7 (63.7%) Nidus remaining after 3 4 years (36.4%) Radiation necrosis 1 (9.1%) 2 (28.6%) 1 (14.3%) 6 (85.7%) 1 (14.3%)
32 α/β-values for AVM cure Kocher M, et al. (2004) 3.54 (>3.5 cm) (<3.5 cm) Thus, we assumed that α/β-value for AVM 3 cm obliteration is 3.5.
33 Reported series of fractionated radiotherapy for large AVM Author/Year method cases dose/frac follow cure (%) Redekop/1993 LINAC / Kocher/2004 LINAC 40 50/25 > /4 >2 0 Venzendaroglu/2004 LINAC 7 42/ / Chang/2004 LINAC / Silander/2004 Proton / /4 3 0
34 α/β = 3.5 Fx size Fx (D) BED (Gy) Oblit (%) 8 4 (32) (42) (24) (20) (30) (50) GyE/fx, Total 36 GyE: BED = 97.7 Gy GyE/fx, Total 45 GyE: BED = 83.6 Gy 3.5
35 Recent cases ( ) Age Gender Size (mm) S-M Grade Pretreatment Proton Follow-up 1 23/M Emboli months 2 28/M Emboli months 3 71/M None months 4 28/F None months 5 25/F None months 6 40/M None month
36 23 y.o. man Left occipital AVM with Spezler -Martin grade 5 ( mm) 36 GyE / 6 fractions 36 months later
37 Acknowledgement Dr. Koichi Tokuuye Dr. Hidetsugu Nakayama Dr. Shinji Sugawara At the Campus of the University of Tsukuba, Apr. 2008
38 Thank you for your attention.
Collection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org The Role of Radiosurgery in the Treatment of Gliomas Luis Souhami, MD Professor Department of Radiation
Proton Beam Therapy for Hepatocellular Carcinoma. Li Jiamin, MD Wanjie Proton Therapy Center
Proton Beam Therapy for Hepatocellular Carcinoma Li Jiamin, MD Wanjie Proton Therapy Center 1 1 Hepatocelluar carcinoma (HCC) is one of the most common cancers worldwide It is the eighth most common neoplasm
Radiation Therapy for Liver Malignancies
Outline Radiation Therapy for Liver Malignancies Albert J. Chang, M.D., Ph.D. Department of Radiation Oncology, UCSF March 23, 2014 Rationale for developing liver directed therapies Liver directed therapies
4D Radiotherapy in early ca Lung. Prof. Manoj Gupta Dept of Radiotherapy & oncology I.G.Medical College Shimla
4D Radiotherapy in early ca Lung Prof. Manoj Gupta Dept of Radiotherapy & oncology I.G.Medical College Shimla Presentation focus on ---- Limitation of Conventional RT Why Interest in early lung cancer
11/28/2018. Proton Therapy for Liver Cancer: Who, Why, and How. Disclosures. Michael Chuong, MD. None
Proton Therapy for Liver Cancer: Who, Why, and How Michael Chuong, MD Disclosures None 1 Rationale for proton therapy Hepatic toxicity Biliary toxicity GI toxicity Potentially significant benefit especially
Where are we with radiotherapy for biliary tract cancers?
Where are we with radiotherapy for biliary tract cancers? Professor Maria A. Hawkins Associate Professor in Clinical Oncology MRC Group Leader/Honorary Consultant Clinical Oncologist CRUK MRC Oxford Institute
Stereotactic Body Radiotherapy (SBRT) For HCC T A R E K S H O U M A N P R O F. R A D I A T I O N O N C O L O G Y N C I, C A I R O U N I V.
Stereotactic Body Radiotherapy (SBRT) For HCC T A R E K S H O U M A N P R O F. R A D I A T I O N O N C O L O G Y N C I, C A I R O U N I V. Hepatocellular carcinoma (HCC), is a major health problem worldwide.
Chapter 13 Proton Therapy for Thoracoabdominal Tumors
Chapter 13 Proton Therapy for Thoracoabdominal Tumors Hideyuki Sakurai, Toshiyuki Okumura, Shinji Sugahara, Hidetsugu Nakayama, and Koichi Tokuuye Abstract In advanced-stage disease of certain thoracoabdominal
Status of H 1 and C 12
Status of H 1 and C 12 Herman Suit No Conflict of Interest 1 Goal of a New Treatment Modality Tumor Control Probability or No in Complication Rate 2 Truism No Advantage to: any Patient for any Radiation
Non-small cell lung cancer (NSCLC) is a common cause
ORIGINAL ARTICLE Results of Proton Beam Therapy without Concurrent Chemotherapy for Patients with Unresectable Stage III Non-small Cell Lung Cancer Yoshiko Oshiro, MD,* Masashi Mizumoto, MD,* Toshiyuki
RTOG Lung Cancer Committee 2012 Clinical Trial Update. Wally Curran RTOG Group Chairman
RTOG Lung Cancer Committee 2012 Clinical Trial Update Wally Curran RTOG Group Chairman 1 RTOG Lung Committee: Active Trials Small Cell Lung Cancer Limited Stage (Intergroup Trial) Extensive Stage (RTOG
Clinical Report for Wanjie Proton Therapy Center. Li Jiamin, MD Wanjie Proton Therapy Center
Clinical Report for Wanjie Proton Therapy Center Li Jiamin, MD Wanjie Proton Therapy Center General Information Wanjie Proton Therapy Center was founded in June 2001 The first patient was treated in Dec.
Might Adaptive Radiotherapy in NSCLC be feasible in clinical practice?
Might Adaptive Radiotherapy in NSCLC be feasible in clinical practice? E.Molfese, P.Matteucci, A.Iurato, L.E.Trodella, A.Sicilia, B.Floreno, S.Ramella, L.Trodella Radioterapia Oncologica, Università Campus
肺癌放射治療新進展 Recent Advance in Radiation Oncology in Lung Cancer 許峰銘成佳憲國立台灣大學醫學院附設醫院腫瘤醫學部
肺癌放射治療新進展 Recent Advance in Radiation Oncology in Lung Cancer 許峰銘成佳憲國立台灣大學醫學院附設醫院腫瘤醫學部 Outline Current status of radiation oncology in lung cancer Focused on stage III non-small cell lung cancer Radiation
Fractionated Stereotactic Radiotherapy. Rationale, indications, & treatment techniques
Fractionated Stereotactic Radiotherapy Rationale, indications, & treatment techniques Radiobiological principles The BED (Gy) = D(1 + d/α/β) Assume BED 1 = BED 2 for tissue of an unknown α/β: Optic
Tecniche Radioterapiche U. Ricardi
Tecniche Radioterapiche U. Ricardi UNIVERSITA DEGLI STUDI DI TORINO Should we always rely on stage? T4N0M0 Stage IIIB T2N3M0 Early stage NSCLC The treatment of choice for early-stage NSCLC is anatomic
Radiation Technology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo, JAPAN
Analysis of Visual Loss Due to Radiation- Induced Optic Neuropathy After Particle Therapy for Head and Neck and Skull Base Tumors Adjacent to Optic Nerves Y. Demizu 1, M. Murakami 1, D. Miyawaki 1, Y.
Stereotactic radiotherapy
Stereotactic radiotherapy Influence of patient positioning and fixation on treatment planning - clinical results Frank Zimmermann Institut für Radioonkologie Universitätsspital Basel Petersgraben 4 CH
Clinical Session 3 Liver Cancer. Toshiyuki Okumura M.D. Takayuki Hashimoto M.D. Proton Medical Research Center University of Tsukuba
Clinical Session 3 Liver Cancer Toshiyuki Okumura M.D. Takayuki Hashimoto M.D. Proton Medical Research Center University of Tsukuba Liver Cancer: Topics for today Anatomy Epidemiology Risk factors of liver
Radiotherapy for liver cancer
Received: 7 November 2015 Accepted: 10 March 2016 DOI: 10.1002/jgf2.19 REVIEW ARTICLE Radiotherapy for liver cancer Nobuyoshi Fukumitsu MD Toshiyuki Okumura MD Hideyuki Sakurai MD Proton Medical Research
SBRT in early stage NSCLC
SBRT in early stage NSCLC Optimal technique and tumor dose Frank Zimmermann Clinic of Radiotherapy and Radiation Oncology University Hospital Basel Petersgraben 4 CH 4031 Basel radioonkologiebasel.ch Techniques
Targeted Radiation +/- Biologics News Briefing
Targeted Radiation +/- Biologics News Briefing Wednesday, October 31, 2012 7:00 a.m. 7:45 a.m. Catherine Park, MD Vice-chairman of the ASTRO Education Committee Eric Chang, MD ASTRO Annual Meeting Scientific
Therapy of Non-Operable early stage NSCLC
SBRT Stage I NSCLC Therapy of Non-Operable early stage NSCLC Dr. Adnan Al-Hebshi MD, FRCR(UK), FRCP(C), ABR King Faisal Specialist Hospital & Research Centre This is our territory Early Stages NSCLC Surgical
DOES RADIOTHERAPY TECHNIQUE / DOSE / FRACTIONATION REALLY MATTER? YES
DOES RADIOTHERAPY TECHNIQUE / DOSE / FRACTIONATION REALLY MATTER? YES Marco Krengli Radiotherapy, Department of Translational Medicine, University of Piemonte Orientale A. Avogadro THE STANDARD OF CARE
Otolaryngologist s Perspective of Stereotactic Radiosurgery
Otolaryngologist s Perspective of Stereotactic Radiosurgery Douglas E. Mattox, M.D. 25 th Alexandria International Combined ORL Conference April 18-20, 2007 Acoustic Neuroma Benign tumor of the schwann
American College of Radiology ACR Appropriateness Criteria
American College of Radiology ACR Criteria Thyroid Carcinoma Variant 1: T1a N0 M0 papillary thyroid cancer: 40-year-old woman. 30 mci with thyrotropin 100 mci with thyrotropin 30 mci with thyroid hormone
Medical Policy Manual. Topic: Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy. Date of Origin: January 1996
Medical Policy Manual Topic: Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy Date of Origin: January 1996 Section: Surgery Last Reviewed Date: June 2014 Policy No: 16 Effective Date:
Results of Stereotactic radiotherapy for Stage I and II NSCLC Is There a Need for Image Guidance?
Results of Stereotactic radiotherapy for Stage I and II NSCLC Is There a Need for Image Guidance? Frank Zimmermann Institute of Radiation Oncolgy University Clinic Basel Petersgraben 4 CH 4031 Basel radioonkologiebasel.ch
PTCOG 46. Educational Workshop Session IV. Head & Neck CLINICAL. J. Mizoe (NIRS, Japan)
PTCOG 46 Educational Workshop Session IV CLINICAL Head & Neck J. Mizoe (NIRS, Japan) Photon X-Ray γ-ray Fast Neutron Non-Charged Radiation Electron Proton Helium Light Ion Heavy Particle Carbon Neon Argon
Protons for Head and Neck Cancer. William M Mendenhall, M.D.
Protons for Head and Neck Cancer William M Mendenhall, M.D. Protons for Head and Neck Cancer Potential Advantages: Reduce late complications via more conformal dose distributions Likely to be the major
Radiation Therapy: From Fallacy to Science
27 th Annual Management of Colon and Rectal Diseases 2.23.2019 Radiation Therapy: From Fallacy to Science Hadi Zahra, MD, DABR Radiation Oncologist CHI Health Henry Lynch Cancer Center Assistant Clinical
Linac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR
Linac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR PhD, FAAPM, FACR, FASTRO Department of Radiation Oncology Indiana University School of Medicine Indianapolis, IN, USA Indra J. Das,
Hamad Alsuhaibani,MD KING FAISAL SPECIALIST HOSPITAL &RESEARCH CENTRE.
Hamad Alsuhaibani,MD KING FAISAL SPECIALIST HOSPITAL &RESEARCH CENTRE. YTTRIUM-90( 90 Y) TRANSARTERIAL HEPATIC RADIOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA EFFICACY AND SAFETY OF YTTRIUM-90 RADIO- EMBOLIZATION
Hypofractionated RT in Cervix Cancer. Anuja Jhingran, MD
Hypofractionated RT in Cervix Cancer Anuja Jhingran, MD Hypofractionated RT in Cervix Cancer: Clinicaltrials.gov 919 cervix trials 134 hypofractionated RT trials Prostate, breast, NSCLC, GBM 0 cervix trials
Proton beam therapy for liver tumors
Proton beam therapy for liver tumors University of Tsukuba, Japan Hideyuki Sakurai, Toshiyuki Okumura, Nobuyoshi Fukumitsu, Hitoshi Ishikawa, Kayoko Ohnishi, Masashi Mizumoto, Keiko Murofushi, Haruko Numajiri,
Review of Workflow NRG (RTOG) 1308: Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Chemoradiation Therapy for
Review of Workflow NRG (RTOG) 1308: Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Chemoradiation Therapy for Inoperable Stage II-IIIB NSCLC 1 Co-Chairs Study Chair: Zhongxing
Protocolos de consenso: MTS Cerebrales Resumen ASTRO. Javier Aristu y Germán Valtueña Servicio Oncología Rad. Depart.
Protocolos de consenso: MTS Cerebrales Resumen ASTRO Javier Aristu y Germán Valtueña Servicio Oncología Rad. Depart. ASTRO 2013 Brain met SRS Abstracts 97. Comparative Effectiveness of SRS versus WBRT
Chemo-radiotherapy in non-small cell lung cancer. HARMESH R NAIK, MD. September 25, 2002
Chemo-radiotherapy in non-small cell lung cancer HARMESH R NAIK, MD. September 25, 2002 Epidemiology Estimated 170000 new cases Estimated 157,000 deaths Second commonest cancer diagnosis in men and women
Dose escalation for NSCLC using conformal RT: 3D and IMRT. Hasan Murshed
Dose escalation for NSCLC using conformal RT: 3D and IMRT. Hasan Murshed Take home message Preliminary data shows CRT technique in NSCLC allows dose escalation to an unprecedented level maintaining cancer
A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors
A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors The Harvard community has made this article openly available. Please share how this access benefits you. Your story
THE ROLE OF RADIATION THERAPY IN MANAGEMENT OF PANCREATIC ADENOCARCINOMA. TIMUR MITIN, MD, PhD
THE ROLE OF RADIATION THERAPY IN MANAGEMENT OF PANCREATIC ADENOCARCINOMA TIMUR MITIN, MD, PhD RESECTABLE DISEASE MANAGEMENT: RESECTABLE DISEASE Resection offers the only possibility of long term survival
ES-SCLC Joint Case Conference. Anthony Paravati Adam Yock
ES-SCLC Joint Case Conference Anthony Paravati Adam Yock Case 57 yo woman with 35 pack year smoking history presented with persistent cough and rash Chest x-ray showed a large left upper lobe/left hilar
The Role of Radiation Therapy in the Treatment of Brain Metastases. Matthew Cavey, M.D.
The Role of Radiation Therapy in the Treatment of Brain Metastases Matthew Cavey, M.D. Objectives Provide information about the prospective trials that are driving the treatment of patients with brain
ONCOLOGY LETTERS 10: , 2015
ONCOLOGY LETTERS 10: 201-205, 2015 Proton beam therapy for locally advanced and unresectable (T4bN0M0) squamous cell carcinoma of the ethmoid sinus: A report of seven cases and a literature review TAKASHI
News Release. Embargoed until 1:45 p.m. ET, Sunday, October 28, 2012
News Release Embargoed until 1:45 p.m. ET, Sunday, October 28, 2012 Contact: Michelle Kirkwood 703-286-1600 michellek@astro.org Concurrent use of sorafenib and stereotactic body radiotherapy for advanced
Questions may be submitted anytime during the presentation.
Understanding Radiation Therapy and its Role in Treating Patients with Pancreatic Cancer Presented by Pancreatic Cancer Action Network www.pancan.org August 18, 2014 If you experience technical difficulty
Radiotherapy Planning (Contouring Lung Cancer for Radiotherapy dose prescription) Dr Raj K Shrimali
Radiotherapy Planning (Contouring Lung Cancer for Radiotherapy dose prescription) Dr Raj K Shrimali Let us keep this simple and stick to some basic rules Patient positioning Must be reproducible Must be
IGRT Protocol Design and Informed Margins. Conflict of Interest. Outline 7/7/2017. DJ Vile, PhD. I have no conflict of interest to disclose
IGRT Protocol Design and Informed Margins DJ Vile, PhD Conflict of Interest I have no conflict of interest to disclose Outline Overview and definitions Quantification of motion Influences on margin selection
Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We
Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We Edward Garon, MD, MS Associate Professor Director- Thoracic Oncology Program David
Combined Modality Therapy State of the Art. Everett E. Vokes The University of Chicago
Combined Modality Therapy State of the Art Everett E. Vokes The University of Chicago What we Know Some patients are cured (20%) Induction and concurrent chemoradiotherapy are each superior to radiotherapy
Radiation Therapy in the 21 st Century Competing Technologies
Radiation Therapy in the 21 st Century Competing Technologies 2 nd Workshop on Hadron Beam Therapy of Cancer Stephen M. Hahn May 21, 2011 The Evolution of Radiation Therapy 1960 s The First Clinac Standard
Stage III Non-Small Cell Lung Cancer, Is There Any Progress? HARMESH R NAIK, MD. KARMANOS CANCER INSTITUTE 2/24/99
Stage III Non-Small Cell Lung Cancer, Is There Any Progress? HARMESH R NAIK, MD. KARMANOS CANCER INSTITUTE 2/24/99 Introduction 1/3 of the total lung cancer cases few patients are cured with single modality
Proton beam therapy with concurrent chemotherapy for glioblastoma multiforme: comparison of nimustine hydrochloride and temozolomide
J Neurooncol DOI 1.17/s11-1-2228-4 CLINIcAL STUDY Proton beam therapy with concurrent chemotherapy for glioblastoma multiforme: comparison of nimustine hydrochloride and temozolomide Masashi Mizumoto 1
Quality Variation and Clinical Impact in Head and Neck IMRT
Quality Variation and Clinical Impact in Head and Neck IMRT 6 th IMRT Symposium, New York Sep. 20, 2010 K.S. Clifford Chao, MD Chairman, Combined Radiation Oncology, New York Presbyterian Hospital Chairman,
ARROCase: Borderline Resectable Pancreatic Cancer
ARROCase: Borderline Resectable Pancreatic Cancer Resident: Jordan Kharofa, MD Staff: Beth Erickson, MD 8/2012 Medical College of Wisconsin Department of Radiation Oncology Case Presentation: 60 year old
ANALYSIS OF TREATMENT OUTCOMES WITH LINAC BASED STEREOTACTIC RADIOSURGERY IN INTRACRANIAL ARTERIOVENOUS MALFORMATIONS
ANALYSIS OF TREATMENT OUTCOMES WITH LINAC BASED STEREOTACTIC RADIOSURGERY IN INTRACRANIAL ARTERIOVENOUS MALFORMATIONS Dr. Maitri P Gandhi 1, Dr. Chandni P Shah 2 1 Junior resident, Gujarat Cancer & Research
Comparison of IMRT and VMAT Plan for Advanced Stage Non-Small Cell Lung Cancer Treatment
Research Article imedpub Journals www.imedpub.com Archives in Cancer Research DOI: 10.21767/2254-6081.100185 Comparison of IMRT and VMAT Plan for Advanced Stage Non-Small Cell Lung Cancer Treatment Abstract
Jefferson Digital Commons. Thomas Jefferson University. Maria Werner-Wasik Thomas Jefferson University,
Thomas Jefferson University Jefferson Digital Commons Department of Radiation Oncology Faculty Papers Department of Radiation Oncology May 2008 Increasing tumor volume is predictive of poor overall and
Specification of Tumor Dose. Prescription dose. Purpose
Specification of Tumor Dose George Starkschall, Ph.D. Department of Radiation Physics U.T. M.D. Anderson Cancer Center Prescription dose What do we mean by a dose prescription of 63 Gy? Isocenter dose
THORACIC MALIGNANCIES
THORACIC MALIGNANCIES Summary for Malignant Malignancies. Lung Ca 1 Lung Cancer Non-Small Cell Lung Cancer Diagnostic Evaluation for Non-Small Lung Cancer 1. History and Physical examination. 2. CBCDE,
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy Policy Number: 6.01.10 Last Review: 11/2013 Origination: 1/1989 Next Review: 11/2014 Policy Blue Cross and Blue Shield of Kansas City (Blue
NRG Oncology Lung Cancer Portfolio 2016
NRG Oncology Lung Cancer Portfolio 2016 Roy Decker, MD PhD Yale Cancer Center Walter J Curran, Jr, MD Winship Cancer Institute of Emory University NRG Oncology Lung Cancer Selected Discussion Stage III
Institute of Oncology & Radiobiology. Havana, Cuba. INOR
Institute of Oncology & Radiobiology. Havana, Cuba. INOR 1 Transition from 2-D 2 D to 3-D 3 D conformal radiotherapy in high grade gliomas: : our experience in Cuba Chon. I, MD - Chi. D, MD - Alert.J,
and Strength of Recommendations
ASTRO with ASCO Qualifying Statements in Bold Italics s patients with T1-2, N0 non-small cell lung cancer who are medically operable? 1A: Patients with stage I NSCLC should be evaluated by a thoracic surgeon,
Tania Kaprealian, M.D. Assistant Professor UCLA Department of Radiation Oncology August 22, 2015
Tania Kaprealian, M.D. Assistant Professor UCLA Department of Radiation Oncology August 22, 2015 Most common brain tumor, affecting 8.5-15% of cancer patients. Treatment options: Whole brain radiation
Sacral Chordoma: The Loma Linda University Radiation Medicine Experience. Kevin Yiee MD, MPH Resident Physician
Sacral Chordoma: The Loma Linda University Radiation Medicine Experience Kevin Yiee MD, MPH Resident Physician What is a chordoma? 1 st chordoma discovered in clivus by Virchow and Luschka 1856 Rare tumor
CALGB Thoracic Radiotherapy for Limited Stage Small Cell Lung Cancer
CALGB 30610 Thoracic Radiotherapy for Limited Stage Small Cell Lung Cancer Jeffrey A. Bogart Department of Radiation Oncology Upstate Medical University Syracuse, NY Small Cell Lung Cancer Estimated 33,000
Proton Therapy: Where Are We Now and Where Are We Going? Erin Davis MSN, CRNP, ACNP BC Lead Nurse Practitioner
Proton Therapy: Where Are We Now and Where Are We Going? Erin Davis MSN, CRNP, ACNP BC Lead Nurse Practitioner Genevieve Hollis MSN, CRNP, ANP-BC, AOCN Oncology Nurse Practitioner Advanced Senior Lecturer-B
Outline. WBRT field. Brain Metastases. Whole Brain RT Prophylactic WBRT Stereotactic radiosurgery (SRS) 1 fraction Stereotactic frame
Radiation Therapy for Advanced NSC Lung Ca Alexander Gottschalk, M.D., Ph.D. Associate Professor Director of CyberKnife Radiosurgery Department of Radiation Oncology University of California San Francisco
Adjuvant Radiotherapy for completely resected NSCLC
Adjuvant Radiotherapy for completely resected NSCLC ESMO Preceptorship on lung Cancer Manchester February 2017 Cécile Le Péchoux Radiation Oncology Department IOT Institut d Oncologie Thoracique Local
Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón
Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Santiago Ponce Aix Servicio Oncología Médica Hospital Universitario 12 de Octubre Madrid Stage III: heterogenous disease
Radiotherapy in NSCLC: What are the ESMO Guidelines?
- The role of radiation in early stage - RT/CT for unresectable NSCLC - Brain metastasis - Oligometastatic disease Radiotherapy in NSCLC: What are the ESMO Guidelines? Jean-Yves DOUILLARD MD PhD Chief
Gynecologic Cancer InterGroup Cervix Cancer Research Network. Management of Cervical Cancer in Resource Limited Settings.
Management of Cervical Cancer in Resource Limited Settings Linus Chuang MD Conflict of Interests None Cervical cancer is the fourth most common malignancy in women worldwide 530,000 new cases per year
PEDIATRIC ORBITAL TUMORS RADIOTHERAPY PLANNING
PEDIATRIC ORBITAL TUMORS RADIOTHERAPY PLANNING ANATOMY ANATOMY CONT ANATOMY CONT. ANATOMY CONT. EYE OF A CHILD Normal tissue tolerance doses (in conventional #) TD 5/5 TD 50/5 Endpoint Gy Gy Optic nerve
Case Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions.
Case Scenario 1 1/3/11 A 57 year old white female presents for her annual mammogram and is found to have a suspicious area of calcification, spread out over at least 4 centimeters. She is scheduled to
Si Hyun Bae, 1,2,3 Do Seon Song, 1,2,3 Myeong Jun Song, 1,4 Woo Jin Chung, 1,5
Comparison of efficacy between hepatic arterial infusion chemotherapy and sorafenib in advanced hepatocellular carcinoma with portal vein tumor thrombosis 1,2,3 Si Hyun Bae, 1,2,3 Do Seon Song, 1,2,3 Myeong
Toramatsu et al. Radiation Oncology 2013, 8:48
Toramatsu et al. Radiation Oncology 2013, 8:48 RESEARCH Open Access What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning
Treatment results of proton beam therapy with chemo-radiotherapy for stage I-III esophageal cancer
Treatment results of proton beam therapy with chemo-radiotherapy for stage I-III esophageal cancer Nobukazu Fuwa 1, Akinori Takada 2 and Takahiro Kato 3 1;Departments of Radiology, Hyogo Ion Beam Medical
Carbon Ion Radiotherapy for Skull Base and Paracervical Chordomas
Carbon Ion Radiotherapy for Skull Base and Paracervical Chordomas Azusa Hasegawa, Jun-etsu Mizoe and Hirohiko Tsujii Research Center Hospital for Charged Particle Therapy National Institute of Radiological
Illawarra Cancer Care Centre
The Audience Who? No apologies! Radiation Oncologists State of Mind Our business Our business is medical Our records are medical records Our information system is electronic medical record Primacy of our
The Evolution of SBRT and Hypofractionation in Thoracic Radiation Oncology
The Evolution of SBRT and Hypofractionation in Thoracic Radiation Oncology (specifically, lung cancer) 2/10/18 Jeffrey Kittel, MD Radiation Oncology, Aurora St. Luke s Medical Center Outline The history
Hepatocellular Carcinoma: A major global health problem. David L. Wood, MD Interventional Radiology Banner Good Samaritan Medical Center
Hepatocellular Carcinoma: A major global health problem David L. Wood, MD Interventional Radiology Banner Good Samaritan Medical Center Hepatocellular Carcinoma WORLDWIDE The #2 Cancer Killer Overall cancer
Head and Neck Reirradiation: Perils and Practice
Head and Neck Reirradiation: Perils and Practice David J. Sher, MD, MPH Department of Radiation Oncology Dana-Farber Cancer Institute/ Brigham and Women s Hospital Conflicts of Interest No conflicts of
Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 7, NUMBER 2, SPRING 2006 Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas Thomas Samuel Ram, a Paul B. Ravindran,
Hypofractionated radiotheapy using helical tomotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis
Kim et al. Radiation Oncology 2013, 8:15 RESEARCH Open Access Hypofractionated radiotheapy using helical tomotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis Ji-Yoon Kim
The Egyptian Journal of Hospital Medicine (October 2017) Vol.69(1), Page
The Egyptian Journal of Hospital Medicine (October 2017) Vol.69(1), Page 1674-1679 Radioembolization in Treatment of Hepatocellular Carcinoma with Portal Vein Invasion Elsahhar Ahmed Hetta, Osama Mohamed
RF Ablation: indication, technique and imaging follow-up
RF Ablation: indication, technique and imaging follow-up Trongtum Tongdee, M.D. Radiology Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Objective Basic knowledge
Simultaneous Integrated Boost or Sequential Boost in the Setting of Standard Dose or Dose De-escalation for HPV- Associated Oropharyngeal Cancer
Simultaneous Integrated Boost or Sequential Boost in the Setting of Standard Dose or Dose De-escalation for HPV- Associated Oropharyngeal Cancer Dawn Gintz, CMD, RTT Dosimetry Coordinator of Research and
Hepatocelluar Carcinoma Clinical Pathways
Hepatocelluar Carcinoma Clinical Pathways The following pathways have been developed through multidisciplinary efforts with physicians from the Mary Bird Perkins Our Lady of the Lake Cancer Center. These
SBRT TREATMENT PLANNING: TIPS + TRICKS. Rachel A. Hackett CMD, RT(T)
SBRT TREATMENT PLANNING: TIPS + TRICKS Rachel A. Hackett CMD, RT(T) OUTLINE Brief radiobiology review 3D CRT Tx Planning VMAT Tx Planning Protocols Other Sites Oligomets Spine Liver Kidney Adrenal Gland
Radiotherapy for NSCLC: Review of conventional and new treatment techniques
Journal of Infection and Public Health (2012) 5, S45 S49 Radiotherapy for NSCLC: Review of conventional and new treatment techniques Ahmed Saadeddin Riyadh Military Hospital, Riyadh, Saudi Arabia KEYWORDS
Clinical Results of Carbon Ion Radiotherapy: The Heidelberg Experience
Clinical Results of Carbon Ion Radiotherapy: The Heidelberg Experience Stephanie E. Combs, MD Department of Radiation Oncology University of Heidelberg, Germany Carbon ion RT at GSI Active beam delivery
Collection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org High Dose Rate Brachytherapy in Cervix Cancer Luis Souhami, MD Professor Department of Radiation Oncology
Outline. Contour quality control. Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT)
Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT) James Kavanaugh, MS DABR Department of Radiation Oncology Division of Medical Physics Outline Importance
Phase II study of FFF-SBRT in 5 fractions for low and intermediate risk prostate cancer
Phase II study of FFF-SBRT in 5 fractions for low and intermediate risk prostate cancer Ciro Franzese, G D Agostino, E Clerici, E Villa, A Tozzi, T Comito, C Iftode, AM Ascolese, F De Rose, S Pentimalli,
COX-2 inhibitor and irradiation. Saitama Cancer Center Kunihiko Kobayashi MD, PhD
COX-2 inhibitor and irradiation Saitama Cancer Center Kunihiko Kobayashi MD, PhD Synthesis of prostaglandins from arachidonic acid by cyclooxygenase (COX) enzymes JNCI 95:1440, 2003 Difference between
Society for Immunotherapy of Cancer (SITC) Immunotherapy for the Treatment of Brain Metastases
Society for Immunotherapy of Cancer (SITC) Immunotherapy for the Treatment of Brain Metastases Geoffrey T. Gibney, MD Georgetown-Lombardi Comprehensive Cancer Center Medstar-Georgetown University Hospital
Nordic Society for Gynecological Oncology Advisory Board of Radiotherapy
Nordic Society for Gynecological Oncology Advisory Board of Radiotherapy Guidelines for postoperative irradiation of cervical cancer Contents: 1. Treatment planning for EBRT. 2 2. Target definition for
RADIOTHERAPY IN THE MANAGEMENT OF CANCERS OF THE URINARY BLADDER
RADIOTHERAPY IN THE MANAGEMENT OF CANCERS OF THE URINARY BLADDER INTRODUCTION Incidence: Mortality: 20/100000/year (Europe) 8-9/100000/year Worldwide fourth most common cancer in men Incidence: 31.1 mortality:
Some Seminal Studies. Chemotherapy Alone is Inadequate. Bladder Cancer Role of Radiation in Bladder Sparing. Primary Radiation for Bladder Cancer
Bladder Cancer Role of Radiation in Bladder Sparing David C. Beyer M.D., FACR, FACRO, FASTRO Arizona Oncology Services Phoenix, Arizona Primary Radiation for Bladder Cancer No modern surgery / XRT randomized