2016 Coffey - Holden Prostate Cancer Academy Meeting. Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer

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1 2016 Coffey - Holden Prostate Cancer Academy Meeting Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer June 23-26, 2016 Loews Coronado Bay Resort Coronado, CA Program Organizing Committee: Sameek Roychowdhury, MD, PhD, Chair (The Ohio State University) Sangeeta Goswani, MD, PhD (The University of Texas MD Anderson Cancer Center) Joseph Ippolito, MD, PhD (Washington University School of Medicine) Saul Priceman, PhD (City of Hope) Colin Pritchard, MD, PhD (University of Washington) Karen Sfanos, PhD (Johns Hopkins University) Sumit Subudhi, MD, PhD (The University of Texas MD Anderson Cancer Center) 1

2 Loews Coronado Bay Resort 4000 Coronado Bay Road Coronado, CA Thursday, June 23, 2016 THURSDAY, JUNE 23, :00 PM - 5:00 PM Registration Constellation Foyer 5:00 PM - 6:00 PM Welcome Reception Marina Terrace 6:00 PM - 7:15 PM Welcome Dinner Marina Terrace 7:15 PM - 7:30 PM Move to Session I Constellation Ballroom Session I: Introduction 7:30 PM - 7:40 PM Welcome and Opening Remarks Stuart Holden, MD Prostate Cancer Foundation; University of California, Los Angeles 7:40 PM - 8:40 PM Immune Checkpoint Blockade in Cancer Therapy James Allison, PhD The University of Texas MD Anderson Cancer Center 2

3 Friday, June 24, 2016 FRIDAY, JUNE 24, 2016 Friday, June 21, :30 AM Registration Constellation Foyer 6:45 AM - 7:45 AM Breakfast Mistral 7:45 AM - 8:00 AM Move to Session II Constellation Ballroom Session II: Charge to Participants: The Big Questions 8:00 AM - 8:30 AM The Big Questions Kenneth Pienta, MD Johns Hopkins University Session III: Turning to the Host for Answers: Impact of the Microenvironment Sangeeta Goswani, MD, PhD The University of Texas MD Anderson Cancer Center 8:30 AM - 8:50 AM Of Platelets, Their Function, and Their Role in Prostate Cancer Edward Plow, PhD Cleveland Clinic 8:50 AM - 9:10 AM First Question: Akash Patnaik, MD, PhD 9:10 AM - 9:20 AM Diversity of the CD8 T-Cell Response in Human Cancer Haydn Kissick, PhD Emory University School of Medicine 9:20 AM - 9:40 AM First Question: Stephen Plymate, MD 3

4 Friday, June 24, :40 AM 10:00 AM Osteoclast Function in the Metastatic Bone Niche G. David Roodman, MD, PhD Indiana University School of Medicine 10:00 AM 10:20 AM First Question: Andrew Hsieh, MD 10:20 AM - 10:30 AM Tumor Stroma in Cancer Progression and Metastasis Raghu Kalluri, MD, PhD The University of Texas MD Anderson Cancer Center 10:30 AM -10:50 AM First Question: Himisha Beltran, MD 10:50 AM - 11:00 AM Investigation of Cancer Progression and Metastasis at the Single- Cell Level Devon Lawson, PhD University of California, Irvine 11:00 AM - 11:20 AM First Question: John Lee, MD 11:20 AM - 11:40 AM Molecular and Metabolic Control of Osteoblast Differentiation and Functions Gerard Karsenty, MD, PhD Columbia University Medical Center 11:40 AM - 12:00 PM First Question: Ana Aparicio, MD 4

5 Friday, June 24, :00 PM 1:00 PM Lowering Cost While Improving Care Steven A. Burd Founder & CEO, Burd Health LLC PCF Board Member 1:00 PM 1:50 PM Lunch Mistral 1:50 PM - 2:00 PM Move to Session IV Constellation Ballroom Session IV: Immuno-Oncology and the Tumor Microenvironment Saul Priceman, PhD City of Hope 2:00 PM - 2:10 PM Prostate Cancer Vaccines Based on Attenuated Listeria Monocytogenes Charles Drake, MD, PhD John Hopkins University 2:10 PM 2:30 PM First Question: Michael Haffner, MD, PhD 2:30 PM - 2:40 PM Epigenetic Changes in T cells in Response to Checkpoint Blockade Sangeeta Goswami, MD, PhD The University of Texas MD Anderson Cancer Center 2:40 PM - 3:00 PM First Question: Christina Jamieson, PhD 3:00 PM - 3:10 PM Myeloids Cells in Cancer Therapy Brian Ruffell, PhD H. Lee Moffitt Cancer Center & Research Institute 3:10 PM - 3:30 PM First Question: Andrew Armstrong, MD 3:30 PM - 3:40 PM From the Clinic to the Lab: What Does the Immunologic Landscape Look Like in Patients With Prostate Cancer? Padmanee Sharma, MD, PhD The University of Texas MD Anderson Cancer Center 3:40 PM - 4:00 PM First Question: Nima Sharifi, MD 5

6 Friday, June 24, :00 PM - 4:20 PM Molecular Mechanisms of Tumor and Bone Interactions Katherine Weilbaecher, MD Washington University School of Medicine 4:20 PM 4:40 PM First Question: Ashley Ross, MD, PhD Session V: Exceptional Non-Responders and the New Landscape of Metastatic Prostate Cancer Sameek Roychowdhury, MD, PhD The Ohio State University 4:40 PM - 4:50 PM The NCI s Exceptional Responder Program William Dahut, MD National Cancer Institute 4:50 PM 5:10 PM First Question: Sean McGuire, MD, PhD 5:10 PM - 5:20 PM Exceptional Non-Responders: Turning the Tide Won Kim, MD University of California, San Francisco 5:20 PM - 5:40 PM First Question: William Nelson, MD, PhD 5:40 PM 5:50 PM Actionable Alterations in Advanced Prostate Cancer: Towards an Umbrella Trial for mcrpc Felix Feng, MD University of California, San Francisco 5:50 PM - 6:10 PM First Question: Steven Cho, MD 6:10 PM 7:10 PM Dinner Marina Terrace 7:10 PM 7:20 PM Move to Session VI Constellation Ballroom 6

7 Friday, June 24, 2016 Session VI: Does the Microbiome Play a Role in Prostate Cancer? Insights from Current Microbiome Research Karen Sfanos, PhD Johns Hopkins University 7:20 PM - 7:30 PM The Sterile Bladder: A Dogma Debunked Alan Wolfe, PhD Loyola University Chicago 7:30 PM - 7:50 PM First Question: Christopher Barbieri, MD, PhD 7:50 PM 8:00 PM Microbiota and Prostate Disease Karen Sfanos, PhD Johns Hopkins University 8:00 PM - 8:20 PM First Question: Wassim Abida, MD, PhD 8:20 PM - 8:30 PM Gut Microbiota Modulate Prostate Cancer Susan Erdman, DVM, MPH Massachusetts Institute of Technology 8:30 PM - 8:50 PM First Question: Adam Dicker, MD, PhD 8:50 PM 9:00 PM Microbiota and Cancer Therapy Romina Goldszmid, PhD National Cancer Institute 9:00 PM - 9:20 PM First Question: William Redmond, PhD 7

8 Saturday, June 25, 2016 SATURDAY, JUNE 25, :45 AM - 7:45 AM Breakfast Mistral 7:45 AM - 8:00 AM Move to Session VII Constellation Ballroom Session VII: DNA Repair Deficiency in Advanced Prostate Cancer Colin Pritchard, MD, PhD University of Washington 8:00 AM 8:20 AM DNA Repair Deficiency and Radiosensitivity in Prostate Cancer Robert Bristow, MD, PhD Princess Margaret Cancer Centre, Canada 8:20 AM - 8:40 AM First Question: Todd Morgan, MD 8:40 AM - 8:50 AM PARP Inhibition in DNA Repair Deficient Advanced Prostate Cancer Joaquin Mateo, MD Institute of Cancer Research, UK 8:50 AM - 9:10 AM First Question: John Isaacs, PhD 9:10 AM - 9:20 AM Germline DNA Repair Gene Mutations in Metastatic Prostate Cancer Heather Cheng, MD, PhD University of Washington 9:20 AM - 9:40 AM First Question: Mark Rubin, MD 8

9 Saturday, June 25, :40 AM 10:00 AM Unmet Needs In Breast Cancer: Implications For Other Diseases Clifford Hudis, MD Memorial Sloan Kettering Cancer Center 10:00 AM 10:20 AM First Question: Andrew Goldstein, PhD 10:20 AM 11:50 AM Session VIII: Big Ideas Part 1: Developing Time Magazine Cover Concepts Moderator: Sameek Roychowdhury, MD, PhD The Ohio State University 11:50 AM Group Pictures 12:00 PM 1:30 PM Lunch Mistral Free Afternoon 1:15 PM 2:15 PM Personal Training Session (RSVP required, limited availability) Lunch available immediately following training session 5:45 PM 6:45 PM Dinner Marina Terrace 6:45 PM 7:00 PM Move to Lecture Session Constellation Ballroom 9

10 Saturday, June 25, :00 PM 7:20 PM Molecular Pathology of Metastatic Prostate Cancer: A Changing Landscape? Angelo De Marzo, MD, PhD Johns Hopkins University 7:20 PM 7:40 PM First Question: Won Kim, MD Session IX: Novel Biomarkers and Applications Sameek Roychowdhury, MD, PhD The Ohio State University 7:40 PM - 7:50 PM Orthogonal Endpoints in CTC Biomarkers: Prediction, Pharmacodynamics, Discovery Joshua Lang, MD University of Wisconsin Carbone Cancer Center 7:50 PM - 8:10 PM First Question: Martin Pomper, MD, PhD 8:10 PM - 8:20 PM Novel Clinical Grade RNAseq Applications for Patient Care Sameek Roychowdhury, MD, PhD The Ohio State University 8:20 PM - 8:40 PM First Question: Martin Gleave, MD 8:40 PM - 8:50 PM Deep Sequencing of Circulating Tumor DNA for Personalized Cancer Detection and Monitoring Maximillian Diehn, MD, PhD Stanford University 8:50 PM - 9:10 PM First Question: Lu Yang, MD 10

11 Sunday, June 26, 2016 SUNDAY, JUNE 26, :00 AM - 6:45 AM Breakfast Mistral 6:45 AM - 7:00 AM Move to Session X Constellation Ballroom 7:00 AM 7:20 AM Molecular Heterogeneity of Primary and Metastatic Prostate Cancer: Implications for Treatment Selection Peter Nelson, MD Fred Hutchinson Cancer Research Center 7:20 AM 7:40 AM First Question: John Kellogg-Parsons, MD Session X: Imaging the Tumor Microenvironment From Micro to Macro Joseph Ippolito, MD, PhD Washington University School of Medicine 7:40 AM - 7:50 AM Single Domain Antibody Fragments as an Imaging and Delivery Platform Hidde Ploegh, PhD Whitehead Institute for Biomedical Research 7:50 AM - 8:10 AM First Question: Robert Den, MD 8:10 AM - 8:20 AM Molecular Profiling of Glycosylation in the Tumor Microenvironment in FFPE Prostate Cancer Tissues by MALDI Mass Spectrometry Imaging Richard Drake, PhD Medical University of South Carolina 8:20 AM - 8:40 AM First Question: Joshi Alumkal, MD 11

12 Sunday, June 26, :40 AM - 8:50 AM Targeted and Functional Imaging of Prostate Cancer: Localized to Metastatic Disease Baris Turkbey, MD National Cancer Institute 8:50 AM - 9:10 AM First Question: Rohit Bose, MD, PhD 9:10 AM - 9:20 AM Hyperpolarized MR Potential for Measuring Metabolism and Microenvironment in Metastatic Prostate Cancer John Kurhanewicz, PhD University of California, San Francisco 9:20 AM - 9:40 AM First Question: Howard Scher, MD 9:40 AM - 10:40 AM Session XI: Big Ideas Part 2: Presenting Challenge Posters Moderator: Sameek Roychowdhury, MD, PhD The Ohio State University Session XII: Closing Remarks 10:40 AM - 11:00 AM Meeting Debrief Kenneth Pienta, MD Johns Hopkins University Howard Soule, PhD Prostate Cancer Foundation Departures - Boxed Lunches Provided 12