STABILITY-INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF NIMESULIDE AND CHLORZOXAZONE IN PHARMACEUTICAL TABLET DOSAGE FORM
|
|
- Marilynn Chandler
- 5 years ago
- Views:
Transcription
1 Page5600 Indo American Journal of Pharmaceutical Research, 2016 ISSN NO: STABILITY-INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF NIMESULIDE AND CHLORZOXAZONE IN PHARMACEUTICAL TABLET DOSAGE FORM Dr. Bhavsar Ankita *, Shah Dhwani Department of Quality assurance, Sat Kaival College of Pharmacy. Gujarat, Anand (Sarsa) India. ARTICLE INFO Article history Received 02/05/2016 Available online 31/05/2016 Keywords Stability Indicating, Hydrolysis, Oxidative, Nimesulide, Chlorzoxazone. Corresponding author Dr. Bhavsar Ankita Department of Quality assurance, Sat Kaival College of Pharmacy, Gujarat, Anand (Sarsa) India ABSTRACT A stability-indicating high performance liquid chromatographic method was developed and validated for quantitative determination of Nimesulide and Chlorzoxazone in tablet dosage form. Isocratic high performance liquid chromatographic method, using a ECO C 8 - (150mm*4.6mm*5μ) (particle size) as stationary phase with mobile phase Methanol: Acetonitrile: 1% Ammonium acetate (25:25:50%v/v/v) with flow rate of 1 ml/min retention time for Nimesulide and Chlorzoxazone were found to be min and 6.223min respectively. Nimesulide and Chlorzoxazone were exposed to acid/base hydrolytic, oxidative, thermal and photolytic stress conditions, and stressed sample were analysed by proposed method. There were no other co-eluting, interfering peaks from excipients, impurities or degradation products due to variable stress conditions. The linearity was obtained in the concentration range of µg/ml for Nimesulide and µg/ml for Chlorzoxazone. Limit of detection was found to be 4.71 μg/ml and μg/ml and data for limit of quantification were found to be μg/ml and μg/ml for Nimesulide and Chlorzoxazone respectively. The mean recoveries were % and % for Nimesulide and Chlorzoxazone, respectively. The accuracy of the method was in compliance with the proposed limits and the precision of the method was satisfactory. The system suitability of the method showed that the performance of the chromatographic system is not significantly influenced by variations of the operational parameters inside an accepted domain. The excellent separation was demonstrated in the chromatograms and no interfering peaks were observed. Hence, the present method was found to be sensitive, rapid, specific, accurate and robust. Please cite this article in press as Dr. Bhavsar Ankita et al. Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Nimesulide and Chlorzoxazone in Pharmaceutical Tablet Dosage Form. Indo American Journal of Pharmaceutical Research.2016:6(05). Copy right 2016 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
2 Page5601 INTRODUCTION Nimesulide (NIM) chemically known as N-(4-nitro-2-phenoxyphenyl) methanesulfonamide (figure: 1). It is a nonsteroidal anti-inflammatory drug (NSAIDs) with broad effects on inflammation and other biochemical processes leading to a multifactorial mode of action. [1-5] NIM is a preferential cyclo-oxygenase-2 (COX-2) inhibitor but its anti-inflammatory and analgesic action also involves activity on a wide range of inflammatory and pain mediators and intracellular pathways including an effect on synovial concentration of substance P (SP) in patients with knee osteoarthritis. [6] NIM is official in British pharmacopeia (BP 2010). [7] Chlorzoxazone (CHZ) chemically known as a 5-chloro-3Hbenzooxazol-2-one (Figure: 2). [8] It is a colourless or white to creamy white crystalline powder, very slightly soluble in water. CHZ is a skeletal muscle relaxant. It acts by inhibiting multi synaptic reflexes involved in producing and maintain skeletal muscle spasm of varied aetiology. It acts on the spinal cord by depressing reflexes. CHZ is a synthetic compound, inhibits antigen-induced broncho spasms and hence, is used to treat asthma and allergic rhinitis. CHZ inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. CHZ may reduce the release of inflammatory leukotrienes. CHZ is used to relieve pain and stiffness caused by muscle strains and sprains [9]. CHZ is official in United States Pharmacopeia (USP 2010) [10]. Literature survey reveals UV, HPLC and stability indicating HPLC methods have been reported for the estimation of NIM or CHZ alone and in combination with other drugs. Currently there is no stability indicating method has been reported for combination of NIM and CHZ till date. So the present study was carried out with the aim to develop simple, accurate, precise and sensitive stability indicating method for simultaneous estimation of NIM and CHZ in combined pharmaceutical dosage form. Figure: 1 Chemical structure of NIM. Figure: 2 Chemical structure of CHZ. MATERIALS AND METHODS Selection of analytical wavelength The standard solution of NIM (10 μg/ml) and CHZ (10 μg/ml) in methanol was scanned in the UV region of nm using methanol as a blank and the overlain spectra were recorded and 290 nm analytical wavelength was selected for estimation of NIM and CHZ. Chromatogram is shown in figure: 3. Selection of mobile phase The mobile phase should be sufficiently transparent at the wavelength of detection methanol: Acetonitrile (ACN), 1% ammonium acetate are the solvents which are tried for selecting solvent for mobile phase. In our studies various mobile phase with different ratio were used. The mobile phase consist of methanol: ACN: 1% ammonium acetate (25:25:50%v/v/v) provided optimum polarity for proper migration, separation and resolution of NIM and CHZ. Preparation of mobile phase A mixture of 25 ml of methanol and 25 ml of ACN in this solution add 50ml volume of 1% ammonium acetate (1gm in 100 ml water) and sonicated for 10 minutes. Preparation of mix standard solution of NIM and CHZ Accurately weighed NIM 50 mg and 125 mg CHZ in 50 ml volumetric flask and make up with methanol from this 2 ml was taken and diluted up to 10ml with methanol. This solution was containing 200 μg/ml of NIM and 500 μg/ml of CHZ. Solution was injected in HPLC chromatogram shown in figure: 4. Preparation of sample solution Twenty tablets were weighed and powdered equivalently to 50 mg of NIM and 125 mg of CHZ which were transferred in 50 ml volumetric flask. 25 ml of methanol was added, sonicated for 20 minute and diluted with methanol up to mark. The solution was filtered. First few ml of filter was discarded. 2 ml of filtrate was diluted to 10 ml with methanol to make 200 μg/ml NIM and 500 μg/ml of CHZ. Chromatogram is shown in figure: 5.
3 Page5602 Table 1: Optimized chromatographic condition. Parameters Conditions Mobile phase Methanol : ACN : 1%ammonium acetate (25:25:50%v/v/v) Stationary Phase ECO-C 8 (15mm*4.6mm*5μ) (particle size) suniest-eco- C 8 Flow rate 1ml/min Run time 20min Volume of injection 20μl Detection wave length 290nm Force degradation study Procedure for preparation of solutions for force degradation study It is a process in which the natural degradation rate of a pharmaceutical formulation is increased by applying the additional stress. The prepared standard solutions (20 mg of NIM and 50 mg of CHZ) and sample solutions (equivalent to 20 mg NIM and 50 mg CHZ) were treated with various degradation conditions, such as acidic (5 ml of 0.1, 1, 2, 5 N HCl, at room temperature for 8, 12, 24, 24 hours), basic (5 ml of 0.1, 1, 2 N NaOH, at room temperature for 8, 12, 24 hours), oxidization (5 ml of 3% H 2 O 2, at room temperature for 24 hours), thermal (20 mg NIM and 50 mg CHZ powder at 105ºC for 24 hours) and photo degradation (20 mg NIM and 50 mg CHZ powder for 24 hours). In above mentioned degradation conditions, each degradation samples were neutralized with respective degradants. Then diluted with 100 ml methanol to achieve the appropriate concentration of 200 μg/ml and 500 μg/ml for NIM and CHZ respectively. This resulting solutions were injected in HPLC. Degradation behaviour: Singh S and Bakshi M, in their article on stress testing suggested a target degradation of % of establishing the stability nature of assay method, as even intermediate degradation product should not interfere at any stage of drug analysis. 11 Although conditions used for force degradation were adjusted to achieve degradation in the range of %, this could not achieve in some cases even after exposures for a prolonged duration. But in basic degradation unknown impurity was found in 2 N NaOH. Figure 6 and 7 showed acidic degradation conditions (5 N HCl) for standard and sample respectively. Figure 8 and 9 showed basic degradation conditions (2N NaOH) for standard and sample respectively and figure 10, 11 showed oxidative degradation conditions for standard and sample respectively. Validation of developed method Validation of the optimized HPLC method was carried out with respect to the following parameters as per ICH Q2 (R1) guidelines. [12] Linearity Stock Solution 50 mg NIM and 125 mg CHZ was transferred in 50 ml volumetric flak add 25 ml methanol and sonicated for 20 min and make up the volume up to the mark. Dilution was done to achieve the appropriate concentration of 1000 μg/ml of NIM and 2500 μg/ml of CHZ. Linearity was prepared as follow. Aliquots from above stock solution (1, 1.5, 2, 2.5, 3) in 10 ml volumetric flask and diluted up to the mark with methanol to give solution having a strength of NIM 100 ppm, 150 ppm, 250 ppm 300 ppm, 350 ppm respectively and for CHZ 250 ppm, 375 ppm, 500 ppm, 650 ppm, 750 ppm respectively. The results are summarized in Table: 3 and calibration curve was shown in figure: 12 and 13 NIM and CHZ respectively. Limit of detection (LOD) and Limit of quantification (LOQ): The detection limit of an analytical method is the lowest amount of analyte in a sample which can be detected but not necessarily quantitated. Limit of quantification is the lowest concentration of analyte in a sample which can be quantitatively determined with acceptable precision and accuracy. DL= 3.3 QL=10 σ =standard deviation of response, S= slope of the calibration curve. The slope S may be estimated from the calibration curve of the analyte. The results are summarized in Table: 4. ACCURACY The accuracy of the test method is demonstrated by % of recovery. The sample preparations are spiked with known amount of standard at three concentration levels and each concentration is injected three times (Like 50% 100% and 150%). Acceptance criteria: The % of recovery should be between 98 to 102%. The results are summarized in Table: 5.
4 Page5603 System suitability parameters Sample solution of NIM and CHZ were injected in triplicates as per the procedure. From the standard chromatogram system suitability parameters like theoretical plates, tailing factor, retention time, area and resolution are evaluated. The results are given in Table: 6. Quantitative estimation of marketed pharmaceutical formulation. The proposed validation method was successfully applied to determine NIM and CHZ injection formulation. 50 mg of NIM and 125 mg of CHZ powdered mixture was transferred in to a 100ml volumetric flask and dissolved in methanol, it was shaken for 30 min and the volume was made up to the mark with methanol, the content was ultra-sonicated for 20 min it contains 1000 μg/ml NIM and 2500 μg/ml of CHZ. The solution was filtered through 0.45μm glass paper. Again from this solution 5ml taken and transferred in to 50 ml volumetric flask and make up with methanol up to the mark. It contain NIM 200 μg/ml and CHZ 500 μg/ml. The assay result obtained for NIM and CHZ was comparable with the corresponding labelled amount. Result are mentioned in Table: 7. RESULTS AND DISCUSSION Selection of analytical wavelength 290 Figure 3: Overlain spectra of NIM and CHZ. From overlain spectra of NIM and CHZ it is observed that Isoabsorptive point of NIM and CHZ is 290nm. Method development In order to develop an isocratic reverse phase HPLC method for the determination of NIM and CHZ in pharmaceutical dosage form the chromatographic conditions were optimized. For better separation and resolution the different solvents were tried. It has been found that methanol: Acetonitrile: and 1% ammonium acetate give better peak shape with ECO-C 8 (15mm*4.6mm*5μ) (particle size) suniest-eco- C 8. The analyte gave better response at 290 nm wavelength using UV detector. The flow rate was kept 1.0 ml/min. There was no peak tailing observed under these optimized chromatographic conditions. The retention times of NIM and CHZ were found to be min for NIM and min for CHZ respectively. Figure4: Chromatogram of NIM, CHZ and mix standard in methanol: ACN: 1%ammonium acetate (25:25:50% v/v/v).
5 Page5604 Figure 5: Chromatogram of marketed formulation containing 200μg/ml of NIM 500μg/ml of CHZ using mobile phase methanol: ACN: 1%ammonium acetate: (25:25:50%v/v/v). Above mentioned both the chromatogram showed that both the drugs had good resolution with good pick shape, sufficient retention time and tailing factor is also within the limit. Force degradation study Acid degradation study of 5 N HCl (with 5ml, 24hr) Figure 6: Chromatogram of mix std (NIM and CHZ). Figure 7: Chromatogram of marketed formulation. There was no impurity found in acid degradation so that it can concluded that drug is stable in acid degradation.
6 Page5605 Base degradation Base degradation with 2N NaOH (with 5ml, 24hr) Figure 8: Chromatogram of formulation (NIM and CHZ). Figure 9: Chromatogram of marketed formulation. Base degradation study showed unknown impurity in 2 N NaOH. Hence it can be said that drug is stable in base degradation up to 1 N NaOH but not stable in further base degradation conditions. Oxidative degradation (3% H 2 O 2, 24hr) Figure 10: Chromatogram of mix std (NIM and CHZ).
7 Page5606 Figure 11: Chromatogram of marketed formulation. It was observed from figure 10 and 11 that no interfering peaks were found with 3% H2O2. So drugs were stable in oxidative degradation. Table 2: Summary data of force degradation. Force degradation study Retention Time Result % Degradation Different condition NIM (min) CHZ (min) NIM (%) CHZ (%) 0.1N HCl(8hr) Negative 83.36% % 1N HCl(12hr) Negative 83.42% 68.43% 2N HCl(24hr) Negative 83.64% 68.44% 5N HCl(24hr) Negative 83.78% % 0.1N NaOH(8hr) Negative 77.90% 80.70% 1N NaOH(12hr) Negative 80.96% 80.69% 2N NaOH(24hr) Positive Unknown Impurity Unknown Impurity Oxidative degradation(3%h 2 O 2 24hr) Negative 81.17% 78.97% Thermal degradation Negative 81.17% 81.14% (105 o C 24hr) Photolytic degradation (longer wavelength 24hr) Negative 81.98% 79.98% Validation of the proposed method The proposed method has been validated for the simultaneous determination of NIM and CHZ formulation as per ICH guidelines. Linearity and Range Linear correlation obtained between peak area Vs concentration range of μg/ml for NIM and μg/ml for CHZ. Calibration curve of these two drugs at 290 nm are shown in figure: 13 and 14. Figure 12: Calibration curve of NIM.
8 Page5607 Figure 13: Calibration curve of CHZ. Table 3: Linearity values of NIM and CHZ. NIM(n=5) CHZ(n=5) Concentration (μg/ml) Mean peak area Concentration (μg/ml) Mean peak area Correlation coefficient Correlation coefficient Limit: Correlation coefficient NLT n=number of replicate injection. Correlation coefficient of NIM and CHZ was found to be and respectively which indicate that proposed method is linear. Table: 4 Limit of detection (LOD) and Limit of quantification (LOQ). Parameters NIM CHZ LOD μg/ml 4.71 μg/ml μg/ml LOQ μg/ml μg/ml μg/ml Accuracy (% Recovery) The recovery experiment was performed by the standard addition method. The % recoveries obtained were % and % for NIM and CHZ respectively. The low value of standard deviation indicates that the proposed method is accurate. Result are shown in table: 5 Table: 5 Accuracy data of NIM and CHZ. Drug % level Amount of sample Mean Area Amount of standard % recovery %RSD taken(mg) (n=3) recover(mg) NIM CHZ n= number of replicate injection. The percentage recovery for each level should be between % as per ICH guideline. The percentage recovery of NIM and CHZ were observed % and % respectively which was found within the limit.
9 Page5608 System suitability parameters The column efficiency, resolution and peak asymmetry were calculated for the standard solution. From the chromatogram of standard solution containg 200 μg/ml NIM and 500 μg/ml CHZ. The value obtained demonstrated the suitability of the system for analysis of this drug combination. Chromatogram given in table 6. Table 6: System suitability data of NIM and CHZ. Parameters NIM±RSD CHZ±RSD Acceptance criteria Theoretical plates 5247± ±0.17 >2000 Tailing factor 1.29± ±0.14 <2 Resolution 11.19±0.40 >2 Retention time 6.251± ±1.69 <20 Area ± ± Flow rate 1ml/min 1ml/min - This method showed all the system suitability parameters were within the limits only. Table no: 7 Analysis of marketed formulation. Sr. no. Actual conc. Conc. Found %Assay NIM CHZ NIM CHZ NIM CHZ (%) (mg/ml) (mg/ml) (mg/ml) (mg/ml) (%) Mean SD %RSD (Limit: NMT 2%) The percentage assay should be between % as per ICH guideline. The % assay of NIM and CHZ was found % and % respectively which is within the limit. CONCLUSION Rapid separation of NIM and CHZ was successfully attained with a relatively short retention time, provides outstanding resolution, good peak shape gave reliable and highly reproducible results on C8 HPLC column. Separation of NIM and CHZ mixture was achieved with a total run time less than 20 minutes. Based on the results obtained from the analysis of forced degraded samples using the described method, it can be concluded that there was no other co-eluting peak with the main peaks and the method was specific for the estimation of NIM and CHZ in the presence of degradation product(s) / impurities. Excellent values for linearity and recovery were achieved together with low LOD and LOQ. The ease in preparation of mobile phase and economy of the components of mobile phase showed explicitly the applicability of this method the best choice in routine analysis of NIM and CHZ in pharmaceutical quality control departments for routine analysis. Conflict of interest The authors declared that they have no conflict of interest. ACKNOWLEDGEMENT The authors are indebted to Indica laboratories for providing the sample of CHZ and NIM. We are highly thankful to Aum research laboratories for providing the necessary guidance to carry out this research work.
10 Page5609 REFERENCES 1. Rainsford KD. Nimesulide a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med. Res. Opin. 2006; 22(3): Warner TD, Giuliano F, Vojnovic I. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc. Natl. Acad. Sci. U S A. 1999; 96(2): Bennett A, Villa G. Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities. Expert Opin Pharmacother 2000; 1: Suleyman H, Cadirci E, Albayrak A. Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug. Curr Med Chem. 2008; 15: Dogan MD, Ataoglu H, Akarsu ES. Nimesulide and Diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats. Fundam. Clin. Pharmacol. 2002; 16(5): Bianchi M, Broggini M, Balzarini P. Effects of Nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib. Int. J. Clin. Pract. 2007; 61: British pharnacopoiea;6th Edn; the stationary office, London medicines and health care product Regulatory Agency,2009,vil II, pp Neil M J. drugs and biological.14th ed. USA: Merck Research Laboratories: pp Rang H P. Dale M M. Ritter J M. Pharmacology. 6th Ed. Churchill Livingston: New York: pp United state oharmacopoiea-34 and national formulary-29; Asia; United States Pharmacopoeia convention, Rockville MD, USA, 2011 vol II, pp Singh S, Bakshi M. Development of validated stability-indicating assay methods-critical review. J. Pharm. Biomed. Anal. 2002; 24: Validation of analytical procedure Methodology ICH Q2 (R1) ICH Harmonized Tripartite Guidelines,
World Journal of Pharmaceutical Research
World Journal of Pharmaceutical ReseaRch Volume 3, Issue 3, 4527-4535. Research Article ISSN 2277 715 DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF RAMOSETRON Zarana
More informationJ Pharm Sci Bioscientific Res (4): ISSN NO
Development and Validation of Analytical Methods for Simultaneous Estimation of Pregabalin and Amitriptyline Hydrochloride in their Combined Marketed Dosage form ABSTRACT: Nikhilkumar Patel, Gurjit Kaur,
More informationISSN (Print)
Scholars Academic Journal of Pharmacy (SAJP) Sch. Acad. J. Pharm., 2014; 3(3): 240-245 Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources) www.saspublisher.com
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2015, 6(4): 30-37 ISSN: 0976-8688 CODEN (USA): PSHIBD Development and validation of stability indicating RP-HPLC method for simultaneous
More informationPankti M. Shah et al, Asian Journal of Pharmaceutical Technology & Innovation, 04 (17); 2016; 07-16
Asian Journal of Pharmaceutical Technology & Innovation ISSN: 2347-8810 Research Article Received on: 30-03-2016 Accepted on: 01-04-2016 Published on: 15-04-2016 Corresponding Author: *Pankti M. Shah,
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(1):138-144 Simultaneous RP HPLC determination of Latanoprost
More informationStability indicating RP-HPLC method development and validation of Etizolam and Propranolol hydrochloride in pharmaceutical dosage form
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationA New Stability-Indicating and Validated RP-HPLC Method for the Estimation of Liraglutide in Bulk and Pharmaceutical Dosage Forms
OPEN ACCESS Eurasian Journal of Analytical Chemistry ISSN: 1306-3057 2017 12(2):31-44 DOI 10.12973/ejac.2017.00152a A New Stability-Indicating and Validated RP-HPLC Method for the Estimation of Liraglutide
More informationMETHOD DEVELOPMENT AND VALIDATION BY RP-HPLC FOR ESTIMATION OF ZOLPIDEM TARTARATE
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Ramalakshmi et al. SJIF Impact Factor 6.647 Volume 7, Issue 2, 1010-1018 Research Article ISSN 2278 4357 METHOD DEVELOPMENT AND VALIDATION BY RP-HPLC
More informationInternational Journal of Drug Research and Technology
Int. J. Drug Res. Tech. 2016, Vol. 6 (2), 34-42 ISSN 2277-1506 International Journal of Drug Research and Technology Available online at http://www.ijdrt.com Original Research Paper DEVELOPMENT AND VALIDATION
More informationDevelopment and Validation for Simultaneous Estimation of Sitagliptin and Metformin in Pharmaceutical Dosage Form using RP-HPLC Method
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.4, pp 1736-1744, Oct-Dec 2013 Development and Validation for Simultaneous Estimation of Sitagliptin and Metformin
More informationSimultaneous estimation of Metformin HCl and Sitagliptin in drug substance and drug products by RP-HPLC method
International Journal of Chemical and Pharmaceutical Sciences 2017, Mar., Vol. 8 (1) ISSN: 0976-9390 IJCPS Simultaneous estimation of Metformin HCl and Sitagliptin in drug substance and drug products by
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS OF TRAMADOL IN PURE AND PHARMACEUTICAL FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 2039-2047 ISSN 0972-768X www.sadgurupublications.com DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS OF TRAMADOL IN PURE AND PHARMACEUTICAL FORMULATIONS
More informationF. Al-Rimawi* Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, East Jerusalem. Abstract
JJC Jordan Journal of Chemistry Vol. 4 No.4, 2009, pp. 357-365 Development and Validation of Analytical Method for Fluconazole and Fluconazole Related Compounds (A, B, and C) in Capsule Formulations by
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2015, 6(1):6-10 ISSN: 0976-8688 CODEN (USA): PSHIBD Validated RP-HPLC method for simultaneous estimation of metformin hydrochloride
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS TOLBUTAMIDE IN PURE AND PHARMACEUTICAL FORMULATIONS
Int. J. Chem. Sci.: 11(4), 2013, 1607-1614 ISSN 0972-768X www.sadgurupublications.com DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS TOLBUTAMIDE IN PURE AND PHARMACEUTICAL FORMULATIONS
More informationRP-HPLC Analysis of Temozolomide in Pharmaceutical Dosage Forms
Asian Journal of Chemistry Vol. 22, No. 7 (2010), 5067-5071 RP-HPLC Analysis of Temozolomide in Pharmaceutical Dosage Forms A. LAKSHMANA RAO*, G. TARAKA RAMESH and J.V.L.N.S. RAO Department of Pharmaceutical
More informationHyderabad, India. Department of Pharmaceutical Chemistry, Glocal University, Saharanpur, India.
International Journal On Engineering Technology and Sciences IJETS RP-HPLC Method development and validation for the Simultaneous Estimation of Metformin and Empagliflozine in Tablet Dosage Form Shaik
More informationJournal of Chemical and Pharmaceutical Research, 2017, 9(9): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(9):70-80 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and Validation of Stability Indicating
More informationAMERICAN JOURNAL OF BIOLOGICAL AND PHARMACEUTICAL RESEARCH
AMERICAN JOURNAL OF BIOLOGICAL AND PHARMACEUTICAL RESEARCH e-issn - 2348-2184 Print ISSN - 2348-2176 Journal homepage: www.mcmed.us/journal/ajbpr VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF
More informationIntroductionn Ilaprazole (ILA) is
Prajapathi et al: Simultaneous Estimation of IIaprazole and Domperi Internatio idone in Pharm maceutical Dosage Form 3549 onal Journal of Pharmaceutical Sciences and Nanotechnology Volume 9 Issue 6 November
More informationAvailable online at Scholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (3):157-161 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationCHAPTER INTRODUCTION OF DOSAGE FORM AND LITERATURE REVIEW
132 CHAPTER 6 DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF PARACETAMOL, TRAMADOL HYDROCHLORIDE AND DOMPERIDONE IN A COMBINED DOSAGE FORM 6.1 INTRODUCTION
More informationAsian Journal of Pharmaceutical Analysis and Medicinal Chemistry Journal home page:
Research Article CODEN: AJPAD7 ISSN: 2321-0923 Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry Journal home page: www.ajpamc.com ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF GEFITINIB
More informationIJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page:
IJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page: ISSN: 2320-2831 Research article Open Access Method development and validation of tenofovir disoproxil fumerate and emtricitabine in combined tablet
More informationDevelopment and Validation of a Simultaneous HPLC Method for Quantification of Amlodipine Besylate and Metoprolol Tartrate in Tablets
Journal of PharmaSciTech 0; ():- Research Article Development and Validation of a Simultaneous HPLC Method for Quantification of Amlodipine Besylate and Metoprolol Tartrate in Tablets * Sayyed Hussain,
More informationRP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form
RP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form S. LAVANYA* 1, SK. MANSURA BEGUM 1, K. NAGAMALLESWARA RAO 2, K. GAYATHRI DEVI 3 Department of pharmaceutical
More informationDevelopment and validation of stability indicating RP-LC method for estimation of calcium dobesilate in pharmaceutical formulations
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (11):236-242 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationJournal of Chemical and Pharmaceutical Research, 2013, 5(1): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2013, 5(1):180-184 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 A simple and sensitive RP-HPLC method for estimation
More informationDevelopment and Validation of Stability Indicating HPTLC Method for Estimation of Seratrodast
ARC Journal of Pharmaceutical Sciences (AJPS) Volume 2, Issue 3, 2016, PP 15-20 ISSN 2455-1538 DOI: http://dx.doi.org/10.20431/2455-1538.0203004 www.arcjournals.org Development and Validation of Stability
More informationA stability indicating RP-HPLC method for simultaneous estimation of darunavir and cobicistat in bulk and tablet dosage form
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (12):89-96 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEX: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS
More informationVolume 2 (6), 2014, Page CODEN (USA)-IJPRUR, e-issn: International Journal of Pharma Research and Health Sciences
CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Simultaneous Determination of Salbutamol
More informationInt. J. Pharm. Sci. Rev. Res., 30(1), January February 2015; Article No. 32, Pages:
Research Article Development and Validation of Stability Indicating RP-HPLC Method for the Estimation of Cilnidipine in Bulk and Pharmaceutical Dosage Form. Atul Kadam* 1, Dr. (Mrs.) Purnima Hamrapurkar
More information438 Full Text Available On
International Journal of Universal Pharmacy and Bio Sciences 2(3): May-June 2013 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES Pharmaceutical Sciences Research Article!!! Received: 17-05-2013;
More informationDETERMINATION OF LOTEPREDNOL ETABONATE AND TOBRAMYCIN IN COMBINED DOSAGE FORM USING RP-HPLC METHOD
280 P a g e e-issn: 2248-9126 Vol 5 Issue 4 2015 280-284. Print ISSN: 2248-9118 Indian Journal of Pharmaceutical Science & Research www.ijpsrjournal.com DETERMINATION OF LOTEPREDNOL ETABONATE AND TOBRAMYCIN
More informationRP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR CILOSTAZOL IN TABLET DOSAGE FORM
IJPAR Vol.5 Issue 4 Oct - Dec -2016 Journal Home page: ISSN:2320-2831 Research article Open Access RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR CILOSTAZOL IN TABLET DOSAGE FORM *1 M. Swapna *, 2 M.Vijay
More informationIsocratic Reversed Phase Liquid Chromatographic Method Validation for the Determination of Cilostazol in Pure and Formulations
Human Journals Research Article October 2015 Vol.:4, Issue:3 All rights are reserved by Rambabu K et al. Isocratic Reversed Phase Liquid Chromatographic Method Validation for the Determination of Cilostazol
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2010, 2(2): 294-299 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationAvailable online Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(9):951-960 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Analytical method development and validation for
More informationInternational Journal of Pharma and Bio Sciences
International Journal of Pharma and Bio Sciences RESEARCH ARTICLE PHARMACEUTICAL ANALYSIS DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF ESCITALOPRAM OXALATE IN TABLET DOSAGE
More informationCHAPTER 2 SIMULTANEOUS DETRMINATION OF ANASTROZOLE AND TEMOZOLOMIDE TEMOZOLOMIDE CAPSULES 20 MG AND ANASTROZOLE TABLETS 1 MG
CHAPTER 2 SIMULTANEOUS DETRMINATION OF ANASTROZOLE AND TEMOZOLOMIDE IN TEMOZOLOMIDE CAPSULES 20 MG AND ANASTROZOLE TABLETS 1 MG ANALYTICAL METHOD VALIDATION REPORT FOR ASSAY 43 2.1 Introduction Analytical
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(2):770-775 Validation of Rapid Liquid Chromatographic
More informationScholars Research Library. Der Pharmacia Lettre, 2015, 7 (5):44-49 (
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):44-49 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationCorresponding Author:
Adv J Pharm Life sci Res, 2017 5;3:1-8 ISSN 2454 3535 (On-line) RP-HPLC Method for Estimation of Mupirocin in Bulk and Pharmaceutical Formulation S.K.Attar 1 *, M.S.Kalshetti 2, N. A. Jadhao 3, N. R. Patel
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2014, 5(5):91-98 ISSN: 0976-8688 CODEN (USA): PSHIBD A novel RP-HPLC method development and validation of Perindopril Erbumine in
More informationA simple validated RP-HPLC method for quantification of sumatriptan succinate in bulk and pharmaceutical dosage form
IJPAR Vol.4 Issue 1 Jan-Mar-2015 Journal Home page: ISSN: 2320-2831 Research article Open Access A simple validated RP-HPLC method for quantification of sumatriptan succinate in bulk and pharmaceutical
More informationAvailable online Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):171-176 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Reverse phase high performance liquid chromatography
More informationDevelopment and Validation of Area Under Curve Method for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form
Development and Validation of Area Under Curve Method for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form ABSTRACT: A Patel* 1, B Shah 2 1 Research Scholar, Dpt. of Pharmacy,
More information36 J App Pharm Vol. 6; Issue 1: 36-42; January, 2014 Rao et al., 2014
36 J App Pharm Vol. 6; Issue 1: 36-42; January, 2014 Rao et al., 2014 Original Research Article SIMPLE AND RAPID LIQUID CHROMATOGRAPHIC METHOD FOR REAL-TIME QUANTIFICATION OF NAPROXEN / ESOMEPRAZOLE MAGNESIUM
More informationSimultaneous Estimation of Gemcitabine Hydrochloride and Capecitabine Hydrochloride in Combined Tablet Dosage Form by RP-HPLC Method
ISSN: 0973-4945; CODEN ECJHAO E- Chemistry http://www.e-journals.net 2011, 8(3), 1212-1217 Simultaneous Estimation of Gemcitabine Hydrochloride and Capecitabine Hydrochloride in Combined Tablet Dosage
More informationRao and Gowrisankar: Stability-indicating RP-HPLC Method for Pseudoephedrine, Ambroxol and Desloratadine
Research Paper Development and Validation of Stability-indicating RP- HPLC Method for the Estimation of Pseudoephedrine, Ambroxol and Desloratadine in Bulk and Tablet Dosage Forms N. MALLIKARJUNA RAO*
More informationJournal of Pharmacreations
Journal of Pharmacreations ISSN: 2348-6295 Pharmacreations Vol.5 Issue 1 Jan- Mar- 2018 Journal Home page: www.pharmacreations.com Research article Open Access Method development and validation of apixaban
More informationReverse Phase HPLC Analysis of Atomoxetine in Pharmaceutical Dosage Forms
Asian Journal of Chemistry Vol. 21, No. 2 (2009), 829-833 Reverse Phase HPLC Analysis of Atomoxetine in Pharmaceutical Dosage Forms B.V.V.S. JAGADEESH, S. SATYANARAYANA RAJU, V.JAYATHIRTHA RAO and J.V.L.N.
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD ESTIMATION OF TOLVAPTAN IN BULK PHARMACEUTICAL FORMULATION
http://www.rasayanjournal.com Vol.4, No.1 (2011), 165-171 ISSN: 0974-1496 CODEN: RJCABP DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR AND ITS PHARMACEUTICAL FORMULATION V. Kalyana Chakravarthy * and
More informationDevelopment and validation of related substances method for Varenicline and its impurities
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (1):304-309 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationISSN: ; CODEN ECJHAO E-Journal of Chemistry 2011, 8(3),
ISSN: 0973-4945; CODEN ECJHAO E- Chemistry http://www.e-journals.net 2011, 8(3), 1275-1279 Simultaneous Determination of Paracetamol, Phenylephrine Hydrochloride, Oxolamine Citrate and Chlorpheniramine
More informationMethod Development and Validation for the Estimation of Saroglitazar in Bulk and Pharmaceutical Dosage Form by RP-HPLC
Original Research Method Development and Validation for the Estimation of Saroglitazar in Bulk and Pharmaceutical Dosage Form by RP-HPLC Hanumantha Rao K 1, Lakshmana Rao A 2,*, Chandra Sekhar KB 3 1 Assistant
More informationS. G. Talele, D. V. Derle. Department of Pharmaceutics, N.D.M.V.P. College of Pharmacy, Nashik, Maharashtra, India
ORIGINAL ARTICLE Stability-indicating high-performance liquid chromatography (HPLC) method development and validation for the determination of quetiapine fumarate in bulk and dosage form S. G. Talele,
More informationDEVELOPMENT AND STABILITY INDICATING HPLC METHOD FOR DAPAGLIFLOZIN IN API AND PHARMACEUTICAL DOSAGE FORM
International Journal of Applied Pharmaceutics ISSN- 0975-7058 Vol 9, Issue 5, 2017 Original Article DEVELOPMENT AND STABILITY INDICATING HPLC METHOD FOR DAPAGLIFLOZIN IN API AND PHARMACEUTICAL DOSAGE
More informationDevelopment and Validation of Stability Indicating HPLC method for Determination of Eperisone HCL in Bulk and in Formulation
Development and Validation of Stability Indicating HPLC method for Determination of Eperisone HCL in Bulk and in Formulation Sanjay Patil 1, Suvarna Vanjari 2, Rajendra Patil 3, Tushar Deshmukh 4 1 TSSM
More informationDEVELOPMENT AND VALIDATION OF NEW HPLC METHOD FOR THE ESTIMATION OF PALIPERIDONE IN PHARMACEUTICAL DOSAGE FORMS
ISSN: 0974-1496 e-issn: 0976-0083 CODEN: RJCABP http://www.rasayanjournal.com http://www.rasayanjournal.co.in DEVELOPMENT AND VALIDATION OF NEW HPLC METHOD FOR THE ESTIMATION OF PALIPERIDONE IN PHARMACEUTICAL
More informationNew RP-HPLC Method for the Determination of Fludarabine in Pharmaceutical Dosage Forms
Online : ISSN 2349-669X Print : ISSN 0973-9874 New RP-HPLC Method for the Determination of Fludarabine in Pharmaceutical Dosage Forms LAKSHMI B 1, *, RAMA KRISHNA K 2 AND JAYAVEERA K N 3 1. Department
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ASSAY AND DISSOLUTION OF METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS
Innovare Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 6, Issue 5, 2014 Original Article DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ASSAY AND
More informationAvailable online at Scholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2014, 6 (6):322-330 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationThe present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective First derivative
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF
More informationAsian Journal of Pharmaceutical Analysis and Medicinal Chemistry Journal home page:
Research Article CODEN: AJPAD7 ISSN: 2321-0923 Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry Journal home page: www.ajpamc.com VALIDATED RP-HPLC METHOD FOR DETERMINATION OF BROMHEXINE
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF LACOSAMIDE IN BULK AND ITS PHARMACEUTICAL FORMULATION
http://www.rasayanjournal.com Vol.4, No.3 (2011), 666-672 ISSN: 0974-1496 CODEN: RJCABP DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR IN BULK AND ITS PHARMACEUTICAL FORMULATION V.Kalyan Chakravarthy*
More informationResearch Article Simultaneous Estimation of DL-Methionine and Pyridoxine Hydrochloride in Tablet Dosage Form by RP-HPLC
Research Article Simultaneous Estimation of DL-Methionine and Pyridoxine Hydrochloride in Tablet Dosage Form by RP-HPLC Shinde Prashanti 1 *, Mane Aruna 2, Palled Mahesh 1, Bhat AR 1 and Karagane Swapna
More informationIAJPS 2018, 05 (01), J. Amutha Iswarya Devi et al ISSN Available online at:
CODEN [USA]: IAJPBB ISSN: 2349-7750 INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES http://doi.org/10.5281/zenodo.1174186 Available online at: http://www.iajps.com Research Article ANALYTICAL METHOD DEVELOPMENT
More informationRP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF BACLOFEN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Int. J. Chem. Sci.: 11(1), 2013, 390-398 ISSN 0972-768X www.sadgurupublications.com RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF BACLOFEN IN BULK AND PHARMACEUTICAL DOSAGE FORMS SAROJ
More informationL. Sriphong, A. Chaidedgumjorn, and K. Chaisuroj
World Academy of Science, Engineering and Technology 55 9 Derivative Spectrophotometry Applied to the Determination of Triprolidine Hydrochloride and Pseudoephedrine Hydrochloride in Tablets and Dissolution
More informationMEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON
Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY
More informationAnalytical Method Development and Validation for the Estimation of Guaifenesin and Dextromethorphan by RP-HPLC
Human Journals Research Article September 2018 Vol.:13, Issue:2 All rights are reserved by Ramya Sree Borra et al. Analytical Method Development and Validation for the Estimation of Guaifenesin and Dextromethorphan
More informationStress Degradation Studies And Validation Method For Quantification Of Aprepitent In Formulations By Using RP-HPLC
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.5, No.4, pp 1462-1468, April-June 2013 Stress Degradation Studies And Validation Method For Quantification Of Aprepitent
More informationDEVELOPMENT OF RP-HPLC METHOD FOR ESTIMATION OF DROTAVERINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
Int. J. Chem. Sci.: 6(4), 2008, 2055-2061 DEVELOPMENT OF RP-HPLC METHOD FOR ESTIMATION OF DROTAVERINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS B. S. SASTRY a, S. GANANADHAMU and G. DEVALA RAO K. V.
More informationInternational Journal of Pharma and Bio Sciences DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF STRONTIUM RANELATE IN SACHET
International Journal of Pharma and Bio Sciences RESEARCH ARTICLE ANALYTICAL CHEMISTRY DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF STRONTIUM RANELATE IN SACHET K.MYTHILI *, S.GAYATRI,
More informationAsian Journal of Chemistry Vol. 21, No. 1 (2009),
Asian Journal of Chemistry Vol. 21, o. 1 (2009), 176-182 imultaneous Estimation of Related Impurities of Tizanidine Hydrochloride in its Active Pharmaceutical Ingradient by Reversed-Phase Liquid Chromatography
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2010, 2(2): 217-222 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationRP-HPLC method development and validation of Rilpivirine
Yasodha A et al / Int. J. of Pharmacy and Analytical Research Vol-6(1) 217 [18-38] IJPAR Vol.6 Issue 1 Jan - Mar -217 Journal Home page: ISSN:232-2831 Research article Open Access RP-HPLC method development
More informationVol-3, Issue-4, Suppl-2, Nov 2012 ISSN: Sheth et al PHARMA SCIENCE MONITOR
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND MITIGLINIDE CALCIUM DIHYDRATE
More informationInternational Journal of Pharmacy and Pharmaceutical Sciences. Research Article
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 6 suppl 2, 2014 Research Article STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE
More informationInternational Journal of Farmacia
International Journal of Farmacia Journal Home page: www.ijfjournal.com Stability indicating analytical method development and validation for estimation of Sacubitril and Valsartan in bulk and pharmaceutical
More informationScholars Research Library. Der Pharmacia Lettre, 2016, 8 (6): (http://scholarsresearchlibrary.com/archive.html)
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (6):217-223 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More information10 Kadam V. N. et al. Ijppr.Human, 2014; Vol. 1(2): 10-21 (Research Article) DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR SIMULTANEOUS ESTIMATION OF VOGLIBOSE, GLIMEPIRIDE AND METFORMIN HYDROCHLORIDE
More informationDhull Rohit, Kumar Sanjay, Jalwal Pawan Department of Chemistry, OPJS Churu, Rajasthan, India
International Journal of Advanced Science and Research ISSN: 2455-4227, Impact Factor: RJIF 5.12 www.allsciencejournal.com Volume 2; Issue 2; March 2017; Page No. 31-40 Validated gradient stability indicating
More informationASSAY AND IMPURITY METHOD FOR DURACOR TABLETS BY HPLC
ASSAY AND IMPURITY METHOD FOR DURACOR TABLETS BY HPLC METHOD APPROVALS Norvin Pharma Inc. Author Analytical Laboratory Approver Analytical Laboratory Group Leader Approver Manager Quality Control Chemistry
More informationDevelopment and validation of UV spectrophotometric estimation of lisinopril dihydrate in bulk and tablet dosage form using area under curve method
Journal of Innovations in Applied Pharmaceutical Sciences www.jiapsonline.com ISSN: 2455-5177 Research article Development and validation of UV spectrophotometric estimation of lisinopril dihydrate in
More informationvii LIST OF TABLES TABLE NO DESCRIPTION PAGE 1.1 System Suitability Parameters and Recommendations Acidic and Alkaline Hydrolysis 15
vii LIST OF TABLES TABLE NO DESCRIPTION PAGE CHAPTER- 1 1.1 System Suitability Parameters and Recommendations 07 1.2 Acidic and Alkaline Hydrolysis 15 1.3 Oxidative Degradation Study 16 1.4 Hydrolysis
More informationA Reverse Phase HPLC Method Development and Validation for the Determination of Paliperidone in Pure and Dosage Forms
Chem Sci Trans., 2013, 2(1), 41-46 Chemical Science Transactions DOI:10.7598/cst2013.268 ISSN/E-ISSN: 2278-3458/2278-3318 RESEARCH ARTICLE A Reverse Phase HPLC Method Development and Validation for the
More informationVALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DEXAMETHASONE AND GRANISETRON IN COMBINED DOSAGE FORMS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DEXAMETHASONE AND GRANISETRON IN COMBINED
More informationValidation of Developed Analytical Method for Balofloxacin Floating Tablets by Reverse Phase High Performance Liquid Chromatography
International Journal of ChemTech Research CODEN (USA): IJCRGG, ISSN: 0974-4290, ISSN(Online):2455-9555 Vol.10 No.10, pp 145-155, 2017 Validation of Developed Analytical Method for Balofloxacin Floating
More informationDevelopment and validation of RP-HPLC method for simultaneous estimation of gliclazide and metformin in pure and tablet dosage form
ISSN: 2320-2831 IJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page: Research article Open Access Development and validation of RP-HPLC method for simultaneous estimation of gliclazide and metformin in
More informationUV-visible derivative spectroscopic method for simultaneous estimation of cefoperazone and tazobactam in injection dosage form
Patel et al. Int J Res Pharm Sci 2017, 7(3); 16 22 ISSN 2249-3522 International Journal of Research in Pharmacy and Science Research Article UV-visible derivative spectroscopic method for simultaneous
More informationResearch Article. ISSN Available online at 746
ISSN 2395-3411 Available online at www.ijpacr.com 746 Research Article Development and Validation of New Analytical Methods for Simultaneous Estimation of Ramipril and Metoprolol succinate by HPLC method
More informationDevelopment and Validation of RP-HPLC Method for the Estimation of Gemigliptin
Human Journals Research Article September 2018 Vol.:13, Issue:2 All rights are reserved by Hajera Khan et al. Development and Validation of RP-HPLC Method for the Estimation of Gemigliptin Keywords: Gemigliptin,
More informationNOVEL RP-HPLC METHOD. B.Lakshmi et a. concentration range KEY INTRODUCTION. Diltiazem is used to. . It works by of contractionn of the. (dilate).
B.Lakshmi et a ISSN-2319-2119 al, The Experiment, January. 2013 Vol..6(4), 365-371 A NOVEL RP-HPLC METHOD FOR THE DETERMINATION OF DILTIAZEM IN PHARMACEUTICAL DRUG PRODUCTS ABSTRACT High resolution RP-HPLC
More informationAbstract. G. D. Patil 1, P. G. Yeole 1, Manisha Puranik 1 and S. J. Wadher 1 *
International Journal of ChemTech Research ISSN : 0974-4290 Vol.1,No.1,pp 16-26, Jan March 2009 A Validated Specific Reverse Phase Liquid Chromatographic Method for the Determination of Valacyclovir in
More informationDevelopment of a Validated RP-HPLC Method for the Analysis of Citicoline Sodium in Pharmaceutical Dosage Form using Internal Standard Method
Research Article Development of a Validated RP-HPLC Method for the Analysis of Citicoline Sodium in Pharmaceutical Dosage Form using Internal Standard Method * S. M. Sandhya, G. Jyothisree, G. Babu Department
More informationMethod Development and Validation for Simultaneous Estimation of Atorvastatin and Ezetimibe in Pharmaceutical Dosage Form by HPLC
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More information