Tumor Grade Improves the Prognostic Ability of American Joint Committee on Cancer Stage in Patients With Penile Carcinoma
|
|
- Alison Cameron
- 5 years ago
- Views:
Transcription
1 Tumor Grade Improves the Prognostic Ability of American Joint Committee on Cancer Stage in Patients With Penile Carcinoma Rodolphe Thuret,* Maxine Sun,* Firas Abdollah, Lars Budaus, Giovanni Lughezzani, Daniel Liberman, Monica Morgan, Rupinder Johal, Claudio Jeldres, Mathieu Latour, Shahrokh F. Shariat, François Iborra, Jacques Guiter, Jean-Jacques Patard, Paul Perrotte and Pierre I. Karakiewicz From the Cancer Prognostics and Health Outcomes Unit (RT, MS, FA, LB, GL, DL, MM, RJ, CJ, SFS, PIK) and Departments of Urology (DL, MM, RJ, CJ, PP, PIK) and Pathology (ML), University of Montreal, Montreal, Quebec, Canada, Departments of Urology, Centre Hospitalier Universitaire de Montpellier (RT, FI, JG), Montpellier and Rennes University (JJP), Rennes, France, and Vita-Salute San Raffaele University (FA, GL), Milan, Italy, and Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf (LB), Hamburg, Germany Purpose: Penile cancer is rare. Thus, predicting cancer specific mortality may be difficult. We devised an accurate and yet easily applicable predictive rule that compares favorably with 2 previous models (73.8% and 74.7% accuracy, respectively). Materials and Methods: We identified patients treated with primary tumor excision for all stages of penile squamous cell carcinoma between 1998 and Disease stage definitions using Surveillance, Epidemiology and End Results stage, American Joint Committee on Cancer stage and TNM classification, and tumor grade were used to predict cancer specific mortality. Predictive accuracy estimates were compared using the DeLong method for related AUCs. Results: Surveillance, Epidemiology and End Results stage alone (1 predictor variable) was least accurate (74.5%). American Joint Committee on Cancer stage with tumor grade (2 predictor variables) was the most simple and most accurate (80.9%, p 0.001). A benefit similar to that of American Joint Committee on Cancer stage with tumor grade was seen for TNM classification and TG (80.7%, p 0.8). However, this rule (4 predictor variables) was more complex than American Joint Committee on Cancer stage and tumor grade. Conclusions: American Joint Committee on Cancer stage combined with tumor grade is the simplest, most accurate cancer specific mortality prediction rule after primary tumor excision for penile squamous cell carcinoma. This method is also more accurate than 2 previous cancer specific mortality prediction rules. Key Words: penis; carcinoma, squamous cell; mortality; nomograms; neoplasm staging PENILE cancer is an uncommon malignancy in the Western world with an incidence of 0.1 to 0.9 new cases per 100,000 males yearly. 1 This rate is lower than in developing countries, such as in some African and South American countries, where penile cancer represents up to 10% of malignant diseases. 2 Of all penile cancers 95% are squamous cell variants. 3 Due to the rarity of SCCP in 2006 Kattan et al devised a nomogram for the standardized prediction of CSM after treatment for primary SCCP in Abbreviations and Acronyms AJCC American Joint Committee on Cancer CSM cancer specific mortality EAU European Association Urology ILND inguinal lymph node dissection PTE primary tumor excision SCCP penile squamous cell carcinoma SEER Surveillance, Epidemiology and End Results TG tumor grade Submitted for publication June 22, Supported by the University of Montreal Health Center Urology Specialists, Fonds de la Recherche en Santé du Quebec, University of Montreal Department of Surgery, University of Montreal Health Center Foundation (PIK) and Association Française d Urologie (RT). Supplementary material for this article can be obtained at staging.html. * Equal study contribution. Correspondence: Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, 1058, rue St-Denis, Montréal, Québec, Canada, H2X 3J4 (telephone: ; FAX: ; pierre. karakiewicz@umontreal.ca) /11/ /0 Vol. 185, , February 2011 THE JOURNAL OF UROLOGY Printed in U.S.A by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC. DOI: /j.juro
2 502 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER a cohort of 175 Italian men. 4 This model relied on 8 predictors and was between 72.8% and 74.7% accurate depending on whether clinical or pathological N substage was used. Several predictors represented detailed pathological variables, ie tumor thickness, growth pattern or venous and/or lymphatic embolization. In 2009 Zini et al devised a simpler model in a North American cohort of 856 men. 5 Only 2 variables were used, including SEER stage and TG, and 73.8% accuracy was recorded. Despite the merits of this model it may have oversimplified the determinants of the SCCP CSM rate. Thus, we revisited the subject of SCCP CSM prediction and tested the ability of 2002 AJCC stage, the 2002 TNM classification, and the combination of AJCC stage or the TNM classification with TG to predict CSM. Our hypothesis was that more detailed and yet universally available information would result in better ability to predict CSM. MATERIALS AND METHODS Study Population In 17 SEER registries we identified all men treated for primary SCCP between 1988 and PTE consisted of excisional biopsy, or partial or total penectomy. The 2 diagnostic coding systems used were ICD-O-2 (C ) and ICD-O-3 codes for histological subtype (squamous cell carcinoma type, ICD-O-3, ). The SEER database includes approximately 26% of the American population and is considered representative of the United States in regard to demographic composition, and cancer incidence and mortality. 6 Only patients with squamous cell histology were included in analysis. TG was stratified according to the SEER database as grades I to III. Cases of confirmed distant metastasis were included and considered M1 even when tumor or nodal stage was unknown. Five patients treated in Alaskan and 2 treated in rural Georgian SEER registries were excluded from study due to exceedingly few observations. Disease stage was tabulated in 3 ways. 1) We relied on SEER stage (localized vs regional vs distant). 2) We used AJCC stage. 3) We relied on the 2002 TNM classification. 7 In patients treated with ILND pathological N substage was used in analysis vs clinical N substage in patients not treated with ILND. All stage assignment was obtained from the SEER database. PTE was considered the start of observation. The cause of death was defined according to the SEER specific cause of death code (28030). For the purpose of analysis death from another cause was considered a censored event or as other cause mortality on competing risks analysis. Statistical Analysis We relied on Kaplan-Meier plots to graphically illustrate CSM-free survival rates in the overall population, and after stratifying by SEER and AJCC stage as well as according to the TNM classification and TG. Three Cox regression models were used to test the accuracy of SEER stage vs AJCC stage vs TNM classification to predict CSM. An additional 3 Cox regression models were fitted using the same disease stages with the addition of TG. Multivariate Cox regression coefficients of the 3 models that relied on disease stage alone as well as of the 3 additional models that relied on disease stage and on TG were then used to generate nomograms. The prognostic ability of nomograms was quantified with ROC derived AUC estimates. 8,9 In Cox regression models the AUC was substituted for by Harrell s concordance index, 10,11 which was used in the current analysis. The prognostic ability of the 3 staging systems with and without TG was tested for predicting the 5-year CSM-free rate. We chose this time point based on the observation that virtually all cancer related events occurred within 5 years after PTE. We tested the statistical significance of the differences in accuracy estimates using the method of DeLong et al to compare related AUCs. 12 We then graphically explored the calibration of all models using the val.surv method. A separate plot was generated for each model without (data not shown) or with the inclusion of TG. Since a proportion of patients with SCCP die of other causes, we used univariate and multivariate competing risks regression models, as described by Fine and Gray, 13 Table 1. Characteristics of 1,324 patients diagnosed with SCCP between 1988 and 2006 in 15 SEER registries No. Pts (%) Race: White 1,134 (85.6) Black 126 (9.5) Other 64 (4.8) Treatment type: Excisional biopsy 286 (21.6) Partial penectomy 835 (63.1) Radical penectomy 203 (15.3) Tumor grade: I 410 (31.0) II 606 (45.8) III 308 (23.3) SEER stage : Localized 729 (55.1) Regional 515 (38.9) Metastatic 80 (6.0) AJCC stage: I 697 (52.6) II 301 (22.7) III 189 (14.3) IV 137 (10.3) 2002 TNM substage : T T1 763 (57.6) T2 334 (25.2) T3 163 (12.3) T4 28 (2.1) TX 36 (2.7) N cn0 948 (71.6) cn1 3/X 72 (5.4) pn0 127 (9.6) pn1 58 (4.4) pn2 62 (4.7) pn3 57 (4.3) M M0 1,273 (96.1) M1 51 (3.9)
3 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER 503 to test the significance of the variables in predicting CSM. Competing risks regression models allow us to account for the effect of other cause mortality. All tests were 2 sided with significance considered at RESULTS Between 1988 and 2006 we identified a total of 1,324 patients with SCCP in 15 SEER registries (table 1). Average age was 66.3 years (median 68.0, range 22 to 102) and 85.6% of the men were white. Partial penectomy, excisional biopsy and radical penectomy were done in 63.1%, 21.6% and 15.3% of patients, respectively. SCCP was grades I to III in 410 (31.1%), 606 (45.8%) and 308 men (23.3%), respectively. According to SEER stage 729 patients (55.1%) had localized, 515 (38.9%) had regional and 80 (6.0%) had distant disease. AJCC stage was I to IV in 697 (52.6%), 301 (22.7%), 189 (14.3%) and 137 patients (10.3%), respectively. When the TNM classification was used, T stage was T1 to T4 in 763 (57.6%), 334 (25.2%), 163 (12.3%) and 28 patients (2.1%), respectively. Of all patients 304 (23.0%) underwent ILND. Pathological N substage was pn0 in 127 patients (9.6%), pn1 in 58 (4.4%), pn2 in 62 (4.7%) and pn3 in 57 (4.3%). Of the 1,020 patients who did not undergo ILND clinical N substage was cn0 in 948 (71.6%) and cn1-3/x in 72 (5.4%). Figure 1, A and B show cumulative CSM incidence-free rates according to Fine and Gray, 13 and CSM-free rates according to the Kaplan-Meier method, respectively. The 2 curves could be virtually superimposed. At 5 years the cumulative incidencefree CSM rate was 83.3% vs 81.1% by the Kaplan- Meier method. After stratifying by SEER stage the 5-year CSMfree survival rate was 91.1%, 75.8% and 18.1% for localized, regional and distant stage, respectively (fig. 1, C). After stratification by AJCC stage the 5-year CSM-free survival rate was 91.4%, 82.7%, 69.4% and 33.0% for stages I to IV, respectively (fig. 1, D). Figure 2 shows stratification by T, N and M stages, and TG. The 5-year CSM-free survival rate was 80.3%, 88.7%, 83.7% and 78.2% in patients with T2 any N any M, pn0 any T any M, M0 any T any N and TG II any T any N any M stage, respectively (fig. 2). In Cox regression models all examined variables achieved statistical significance (p 0.001, table 2). SEER stage, AJCC stage and TNM classification Figure 1. Cumulative incidence plots show CSM-free and other cause mortality-free rates in overall population of 1,324 men (A). Kaplan-Meier survival curve reveals CSM-free rate in overall cohort (B). Kaplan-Meier survival curve shows CSM-free rate by localized vs regional vs distant SEER stage (C). Kaplan-Meier survival curve demonstrates CSM-free rate by AJCC stages I vs II vs III vs IV (D).
4 504 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER Figure 2. Kaplan-Meier plots show CSM-free rate after stratification by T (A), N(B) and M(C) stages, and TG (D) had 74.5%, 77.2% and 78.0% predictive accuracy, respectively (fig. 3). TG as a single predictor of CSM had 66.1% accuracy. The accuracy gain related to the inclusion of TG with SEER stage, AJCC stage and TNM classification was 3.3%, 3.7% and 2.7%, respectively. All accuracy gains were statistically significant (each p 0.02) and resulted in an estimated predictive accuracy of 77.8%, 80.9% and Table 2. Univariate and multivariate Cox regression analysis to predict CSM in 1,324 patients Staging System Alone Staging System Grade* Predictors (stage) HR (95% CI) p Value % AUC HR (95% CI) p Value % AUC SEER: Localized vs regional 3.0 ( ) 2.6 ( ) Localized vs distant 19.5 ( ) 16.1 ( ) AJCC: II vs I 2.0 ( ) 1.8 ( ) III vs I 4.0 ( ) 3.2 ( ) IV vs I 13.4 ( ) 11.0 ( ) TNM T: T2 vs T1 1.9 ( ) 1.3 ( ) T3 vs T1 3.8 ( ) 2.1 ( ) T4 vs T1 3.0 ( ) 1.5 ( ) TX vs T ( ) 1.6 ( ) N: cn1-3/x vs cn0 9.3 ( ) 3.2 ( ) pn0 vs cn0 1.1 ( ) 0.9 ( ) pn1 vs cn0 4.0 ( ) 2.5 ( ) pn2 vs cn0 4.6 ( ) 2.7 ( ) pn3 vs cn0 8.4 ( ) 4.6 ( ) M M1 vs M ( ) 4.8 ( ) * Tumor grade variable not shown.
5 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER 505 Figure 3. Accuracy by concordance index of 5-year CSM-free results of SEER and AJCC stages, and TNM classification without and with TG using method of DeLong et al 12 for related AUCs. Reported p values represent statistical significance of accuracy comparisons using method of DeLong et al. 80.7% for SEER stage, AJCC stage and TNM classification, respectively, combined with TG. Similarly the comparison of accuracy estimates among the 3 staging systems after including TG also achieved statistical significance (each p 0.01, fig. 3). Exceptions were the comparisons between the combination of AJCC stage and TG, and the combination of TNM classification and TG (80.9% and 80.7%, respectively, p 0.8). In competing risks regression models adjusted for other cause mortality SEER stage, AJCC stage and TNM classification achieved statistical significance (each p 0.001, table 3). The statistical significance of all disease staging methods was maintained after including TG (each p 0.01) except for select substage comparisons of the TNM classification. Figure 4, A, C and E shows the effect of each staging systems and of TG on 5-year CSM-free predictions using nomograms. In the nomograms based on SEER stage and TG, and on AJCC stage and TG distant metastasis was the most powerful CSM predictor while for AJCC stage IV SCCP was the most powerful predictor (fig. 4, A and E). In each nomogram high TG was a less influential variable. In the nomogram based on TNM classification and TG pathologically confirmed N3 substage had virtually the same effect as distant metastasis (fig. 4, C). TG II and III had an intermediate effect. T substage was an even less influential variable. Figure 4, B, D and F shows that all 3 models without or combined with TG showed good calibration, as evidenced by the virtually perfect (1:1) relationship between predicted and observed rates. DISCUSSION Despite the availability of 2 models for the standardized prediction of CSM limitations affect these prediction rules. 4,5 The model devised by Kattan et al relied on highly detailed pathological variables, ie tumor thickness and growth pattern, which cannot be obtained from routine pathological assessment of penectomy specimens. 4 Thus, the model of Kattan et al cannot be routinely used in clinical practice. Also, this model was devised in a relatively limited sample of 175 patients treated at a total of 11 Italian Table 3. Univariate and multivariate competing risks regression models to predict CSM in 1,324 patients Staging System Alone Staging System Grade* Predictors (stage) HR (95% CI) p Value HR (95% CI) p Value SEER: Regional vs localized 2.9 ( ) ( ) Distant vs localized 14.3 ( ) ( ) AJCC: II vs I 2.0 ( ) ( ) III vs I 3.7 ( ) ( ) IV vs I 10.8 ( ) ( ) T: T2 vs T1 1.8 ( ) ( ) 0.2 T3 vs T1 3.6 ( ) ( ) T4 vs T1 2.8 ( ) ( ) 0.4 TX vs T ( ) ( ) 0.6 N: cn1 3/X vs cn0 7.7 ( ) ( ) pn0 vs cn0 1.1 ( ) ( ) 0.8 pn1 vs cn0 3.8 ( ) ( ) pn2 vs cn0 4.1 ( ) ( ) pn3 vs cn0 7.1 ( ) ( ) M1 vs M ( ) ( ) * Tumor grade variable not shown.
6 506 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER Figure 4. Nomograms predicting CSM-free rate 5 years after primary tumor excision using SEER stage (A), TNM classification (C) and AJCC stage (E) combined with TG. Calibration between predicted (x axis) and observed (y axis) 5-year CSMfree rate for SEER stage (B), TNM classification (D) and AJCC stage (F) models. tertiary care centers. These considerations may limit the generalizability of this model. Moreover, its accuracy was also intermediate at 74.7%. Zini et al attempted to circumvent the limitations related to the complexity of the nomogram of Kattan et al 4 and the resulting limited clinical applicability. 5 They devised a simple tool in a cohort of 856 North American patients. Despite its similar accuracy and lesser complexity relative to the nomogram of Kattan et al 4 this tool may represent an excessively simplified prediction rule since it relies only on SEER stage and grade. 5 Based on these considerations we compared the ability of SEER stage, AJCC stage and the TNM classification with or without TG to predict CSM-free survival after PTE for SCCP. Our results confirmed that TNM classification yielded the most accurate prediction of 5-year CSM-free survival (78.0%) when considering disease stage alone (fig. 3). When disease stage was combined with TG, AJCC stage and TNM classification yielded the highest and the second highest predictive accuracy (80.9% and 80.7%, respectively, fig. 3). Relative to the nomogram of Kattan et al 4 and to the SEER stage based nomogram 5 the AJCC nomogram had 6.2% and 7.1% better predictions, respectively. This suggests that if predictions are generated in 1,000 consecutive patients, between 62 and 71 may be ranked incorrectly if 1 of the 2 models were chosen over AJCC stage combined with TG. This is not negligible, especially in patients who are potentially misclassified. Combining SEER stage with TG resulted in the least accurate CSM prediction relative to AJCC stage combined with TG (77.8% vs 80.9%). This finding validates our hypothesis that more detailed assessment of tumor stage (AJCC vs SEER stage) yields better accuracy. Our findings are more generalizable than those in previous reports since we relied on 15 SEER registries vs 9 in the analysis by Zini et al. 5 Moreover, our sample size was larger than previously published patient samples, that is 1,324 vs 856 patients described by Zini et al 5 and 175 described by Kattan et al. 4 Our findings are predominantly applicable to North American patients. The natural history of treated SCCP may be significantly different in South America or Asia. Thus, our tool should be validated in cohorts outside Western countries before its use in clinical practice. Application of the current nomogram may affect followup type and frequency. EAU provides guidelines in that regard. 14 However, important heterogeneity may exist between patients in the same EAU risk groupings. For example, 2 men without evidence of lymph node metastasis may have a substantially different 5-year CSM-free probability. Patient 1 may harbor a T2G1 primary tumor (AJCC stage II) without lymph node metastasis. His 5-year CSM-free rate would be 91% according to the nomogram based on AJCC stage and TG. Patient 2 may harbor a T3G2 primary tumor (AJCC stage III) without lymph node metastasis. His 5-year CSMfree rate would be 68% according to the same nomogram. The 23% difference in the 5-year CSM-free rate between the 2 patients may be used as a strategy for more frequent followup in patient 2 relative to patient 1. However, according to the EAU guidelines the same type of followup is recommended, namely regular physician or self-examination with ultrasound investigation of the groin every 6 months for 2 years. This ability to better discriminate between the risk of CSM in these 2 men may be interpreted as an added value of the current nomogram relative to the EAU guidelines. Our prognostic rule is based on Cox regression modeling. However, since a number of patients with SCCP may die of another cause, we confirmed the validity of our predictions in a competing risks regression model. 13 The latter avoids overestimating
7 TUMOR GRADE IMPROVES PROGNOSTIC ABILITY OF STAGE IN PENILE CANCER 507 the effect of CSM rates by adjusting for other cause mortality. CSM Kaplan-Meier based estimations were virtually the same as cumulative incidence estimates derived from the Fine and Gray methodology. 13 For example, at 5 years the CSM-free rate was 83.3% for the Fine and Gray technique vs 81.1% for the Kaplan-Meier method. Based on the striking similarity of the results obtained with the 2 modeling techniques we relied on Cox regression models to develop our prediction rules, as done previously. 5,15 Our study is not devoid of limitations. 1) The lack of central pathology review may have contributed to a higher accuracy of pathologically assessed variables. However, no previously reported nomogram relied on a central pathology review. 4,5 2) Other variables may predict CSM in penile cancer. For example, lymphovascular invasion is an independent prognostic factor for lymph node metastasis and for CSM Phimosis, smoking status or a self-reported history of condyloma are also well recognized prognostic factors. 19,20 Unfortunately these variables could not be obtained from the SEER database and could not be included in our models. CONCLUSIONS Despite the mentioned limitations to our knowledge our prognostic rule represents the simplest and yet most accurate method to predict CSM. It relies on AJCC stage and TG, and provides 81% accurate predictions. It is highly generalizable in men diagnosed and treated for SCCP in the United States. Ideally external validation should be performed. REFERENCES 1. Jemal A, Siegel R, Ward E et al: Cancer statistics, CA Cancer J Clin 2007; 57: Misra S, Chaturvedi A and Misra NC: Penile carcinoma: a challenge for the developing world. Lancet Oncol 2004; 5: Kroon BK, Horemblas S and Niewec OE: Contemporary management of penile squamous cell carcinoma. J Surg Oncol 2005; 89: Kattan MW, Ficarra V, Artibani W et al: Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis. J Urol 2006; 175: Zini L, Cloutier V, Isbarn H et al: A simple and accurate model for prediction of cancer specific mortality in patients treated with surgery for primary penile squamous cell carcinoma. Clin Cancer Res 2009; 15: Ries LA: SEER Cancer Statistics Review. Available at /. Accessed May Sobin LH and Wittekind C: TNM Classification of Malignant Tumours. London: Wiley-Liss Harrell FE Jr, Lee KL and Mark DB: Multivariate prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996; 15: Harrell FE, Califf RM, Pryor DB et al: Evaluating the yield of medical tests. JAMA 1982; 247: Atkinson AC: A note on the generalized information criterion for choice of a model. Biometrika 1980; 67: Grambsch PM and Therneau TM: Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81: DeLong ER, DeLong DM and Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristics curves: a nonparametric approach. Biometrics 1988; 44: Fine JP and Gray RJ: A proportional hazards model for the substitution of a comparing risk. JASA 1999; 94: European Association Urology Guidelines. Available at professional-resources/guidelines/online/. Accessed May Karakiewicz PI, Briganti A, Chun FKH et al: Multiinstitutional validation of a new renal cancerspecific survival nomogram. J Clin Oncol 2007; 25: Ornellas AA, Nobrega BL, Wei Kin Chin E et al: Prognostic factors in invasive squamous cell carcinoma of the penis: analysis of 196 patients treated at the Brazilian National Cancer Institute. J Urol 2008; 180: Bhagat SK, Gopalakrishnan G, Kekre NS et al: Factors predicting inguinal node metastasis in squamous cell cancer of penis. World J Urol 2010; 28: Lopes A, Hidalgo GS, Kowalski LP et al: Prognostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy. J Urol 1996; 156: Daling JR, Madeleine MM, Johnson LG et al: Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 2005; 116: Nordenvall C, Chang ET, Adami HO et al: Cancer risk among patients with condylomata acuminata. Int J Cancer 2006; 119: 888.
Objective. Results. Patients and Methods. Conclusions. Keywords <squamous cell carcinoma of the penis, prognostics, cancerspecific mortality, nomogram
Development and external validation of a prognostic tool for prediction of cancer-specific mortality after complete loco-regional pathological staging for squamous cell carcinoma of the penis Maxine Sun,
More informationA Nomogram Predicting Long-term Biochemical Recurrence After Radical Prostatectomy
1254 A Nomogram Predicting Long-term Biochemical Recurrence After Radical Prostatectomy Nazareno Suardi, MD 1,2 Christopher R. Porter, MD 3 Alwyn M. Reuther, MD 4 Jochen Walz, MD 1,5 Koichi Kodama, MD
More informationEUROPEAN UROLOGY 57 (2010)
EUROPEAN UROLOGY 57 (2010) 956 962 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Urothelial Cancer Editorial by Alexandre R. Zlotta on pp. 970 972 of this
More informationCorrespondence should be addressed to Taha Numan Yıkılmaz;
Advances in Medicine Volume 2016, Article ID 8639041, 5 pages http://dx.doi.org/10.1155/2016/8639041 Research Article External Validation of the Cancer of the Prostate Risk Assessment Postsurgical Score
More informationValidation of the T descriptor in the new 8th TNM classification for non-small cell lung cancer
Original Article Validation of the T descriptor in the new 8th TNM classification for non-small cell lung cancer Hee Suk Jung 1, Jin Gu Lee 2, Chang Young Lee 2, Dae Joon Kim 2, Kyung Young Chung 2 1 Department
More informationJ Clin Oncol 25: by American Society of Clinical Oncology INTRODUCTION
VOLUME 25 NUMBER 24 AUGUST 20 2007 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T A Nomogram Predicting 10-Year Life Expectancy in Candidates for Radical Prostatectomy or Radiotherapy for Prostate
More informationPerigastric lymph node metastases in gastric cancer: comparison of different staging systems
Gastric Cancer (1999) 2: 201 205 Original article 1999 by International and Japanese Gastric Cancer Associations Perigastric lymph node metastases in gastric cancer: comparison of different staging systems
More informationSurgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database
Surgical Management of Metastatic Colon Cancer: analysis of the Surveillance, Epidemiology and End Results (SEER) database Hadi Khan, MD 1, Adam J. Olszewski, MD 2 and Ponnandai S. Somasundar, MD 1 1 Department
More informationZonal Origin of Localized Prostate Cancer Does not Affect the Rate of Biochemical Recurrence after Radical Prostatectomy
european urology 51 (2007) 949 955 available at www.sciencedirect.com journal homepage: www.europeanurology.com Prostate Cancer Zonal Origin of Localized Prostate Cancer Does not Affect the Rate of Biochemical
More informationconcordance indices were calculated for the entire model and subsequently for each risk group.
; 2010 Urological Oncology ACCURACY OF KATTAN NOMOGRAM KORETS ET AL. BJUI Accuracy of the Kattan nomogram across prostate cancer risk-groups Ruslan Korets, Piruz Motamedinia, Olga Yeshchina, Manisha Desai
More informationGUIDELINES ON PENILE CANCER
GUIDELINES ON PENILE CANCER (Text updated March 2005) G. Pizzocaro (chairman), F. Algaba, S. Horenblas, H. van der Poel, E. Solsona, S. Tana, N. Watkin 58 Penile Cancer Eur Urol 2004;46(1);1-8 Introduction
More informationA Non Cancer-Related Survival Benefit Is Associated With Partial Nephrectomy
EUROPEAN UROLOGY 61 (2012) 725 731 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Kidney Cancer Editorial by Alexander Kutikov, Marc C. Smaldone, Brian L.
More informationEvaluation of AJCC, UICC, and Brigham and Women's Hospital Tumor Staging for Cutaneous Squamous Cell Carcinoma
Evaluation of AJCC, UICC, and Brigham and Women's Hospital Tumor Staging for Cutaneous Squamous Cell Carcinoma Karia, et al Methods Details of data collectionfeatures of primary tumors including anatomic
More informationBone Metastases in Muscle-Invasive Bladder Cancer
Journal of the Egyptian Nat. Cancer Inst., Vol. 18, No. 3, September: 03-08, 006 AZZA N. TAHER, M.D.* and MAGDY H. KOTB, M.D.** The Departments of Radiation Oncology* and Nuclear Medicine**, National Cancer
More informationSupplementary appendix
Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Callegaro D, Miceli R, Bonvalot S, et al. Development
More informationORIGINAL ARTICLE. International Journal of Surgery
International Journal of Surgery (2013) 11(S1), S90 S94 Contents lists available at ScienceDirect International Journal of Surgery journal homepage: www.journal-surgery.net ORIGINAL ARTICLE Lymph node
More informationDistribution of prostate specific antigen (PSA) and percentage free PSA in a contemporary screening cohort with no evidence of prostate cancer
Urological Oncology CHUN et al. Distribution of prostate specific antigen (PSA) and percentage free PSA in a contemporary screening cohort with no evidence of prostate cancer Felix K.-H. Chun, Georg C.
More informationExternal validation of the Briganti nomogram to estimate the probability of specimen-confined disease in patients with high-risk prostate cancer
External validation of the Briganti nomogram to estimate the probability of specimen-confined disease in patients with high-risk prostate cancer Mathieu Roumiguié, Jean-Baptiste Beauval, Thomas Filleron*,
More informationEUROPEAN UROLOGY 58 (2010)
EUROPEAN UROLOGY 58 (2010) 742 747 available at www.sciencedirect.com journal homepage: www.europeanurology.com Penile Cancer Prognostic Factors for Occult Inguinal Lymph Node Involvement in Penile Carcinoma
More informationEUROPEAN UROLOGY 60 (2011)
EUROPEAN UROLOGY 60 (2011) 920 930 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Prostate Cancer Editorial by Monique J. Roobol and Eveline A.M. Heijnsdijk
More informationThe index of prediction accuracy: an intuitive measure useful for evaluating risk prediction models
Kattan and Gerds Diagnostic and Prognostic Research (2018) 2:7 https://doi.org/10.1186/s41512-018-0029-2 Diagnostic and Prognostic Research METHODOLOGY Open Access The index of prediction accuracy: an
More informationPredictive Models. Michael W. Kattan, Ph.D. Department of Quantitative Health Sciences and Glickman Urologic and Kidney Institute
Predictive Models Michael W. Kattan, Ph.D. Department of Quantitative Health Sciences and Glickman Urologic and Kidney Institute Treatment for clinically localized prostate cancer Trade off: Substantial
More informationGUIDELINES ON PENILE CANCER
46 E. Solsona (chairman), F. Algaba, S. Horenblas, G. Pizzocaro, T. Windahl Eur Urol 2002;42(3):199-203 Introduction Penile carcinoma is an uncommon malignant disease with an incidence ranging from 0.1
More informationEUROPEAN UROLOGY 61 (2012)
EUROPEAN UROLOGY 61 (2012) 480 487 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Prostate Cancer Editorial by A. Heidenreich on pp. 488 490 of this issue
More informationTable 1. Descriptive characteristics, total prostate-specific antigen, and percentage of free/total prostate-specific antigen distribution Age Groups
Oncology Population-based Analysis of Normal Total PSA and Percentage of Free/Total PSA Values: Results From Screening Cohort Umberto Capitanio, Paul Perrotte, Laurent Zini, Nazareno Suardi, Elie Antebi,
More informationEAU GUIDELINES ON PENILE CANCER
EAU GUIDELINES ON PENILE CANCER (Text update April 2014) O.W. Hakenberg (Chair), E. Compérat, S. Minhas, A. Necchi, C. Protzel, N. Watkin Guidelines Associate: R. Robinson Introduction and epidemiology
More informationThe role of cytoreductive. nephrectomy in elderly patients. with metastatic renal cell. carcinoma in an era of targeted. therapy
The role of cytoreductive nephrectomy in elderly patients with metastatic renal cell carcinoma in an era of targeted therapy Dipesh Uprety, MD Amir Bista, MD Yazhini Vallatharasu, MD Angela Smith, MA David
More informationOnly Estrogen receptor positive is not enough to predict the prognosis of breast cancer
Young Investigator Award, Global Breast Cancer Conference 2018 Only Estrogen receptor positive is not enough to predict the prognosis of breast cancer ㅑ Running head: Revisiting estrogen positive tumors
More informationEAU GUIDELINES ON PENILE CANCER
EAU GUIDELINES ON PENILE CANCER (Text update April 2014) O.W. Hakenberg (Chair), N. Watkin, E. Compérat, S. Minhas, A. Necchi, C. Protzel Introduction and epidemiology The incidence of penile cancer increases
More informationUpper urinary tract urothelial carcinomas (UTUC)
Prognostic Role of Lymphovascular Invasion in Patients with Urothelial Carcinoma of the Upper Urinary Tract Manel Mellouli 1 *, Slim Charfi 1, Walid Smaoui 2, Rim Kallel 1, Abdelmajid Khabir 1, Mehdi Bouacida
More informationPatient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival
MOLECULAR AND CLINICAL ONCOLOGY 7: 1083-1088, 2017 Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival FARUK TAS
More informationBeyond biology: the impact of marital status on survival of patients with adrenocortical carcinoma
ORIGINAL ARTICLE Vol. 41 (6): 1108-1115, November. December, 2015 doi: 10.1590/S1677-5538.IBJU.2014.0348 Beyond biology: the impact of marital status on survival of patients with adrenocortical carcinoma
More informationUrinary Collecting System Invasion is an Independent Prognostic. Factor in Organ Confined Renal Cell Carcinomas.
Author manuscript, published in "Journal of Urology The 2009;182(3):854-9" DOI : 10.1016/j.juro.2009.05.017 Urinary Collecting System Invasion is an Independent Prognostic Factor in Organ Confined Renal
More informationAlthough SCCP is a rare disease in the Brazilian male
Prognostic Factors in Invasive Squamous Cell Carcinoma of the Penis: Analysis of 196 Patients Treated at the Brazilian National Cancer Institute Antonio Augusto Ornellas,* Bernardo Lindenberg Braga Nóbrega,
More informationInformation Content of Five Nomograms for Outcomes in Prostate Cancer
Anatomic Pathology / NOMOGRAMS IN PROSTATE CANCER Information Content of Five Nomograms for Outcomes in Prostate Cancer Tarek A. Bismar, MD, 1 Peter Humphrey, MD, 2 and Robin T. Vollmer, MD 3 Key Words:
More informationORIGINAL ARTICLE. World J Urol (2011) 29: DOI /s
World J Urol (2011) 29:487 494 DOI 10.1007/s00345-011-0645-8 ORIGINAL ARTICLE Concomitant carcinoma in situ as an independent prognostic parameter for recurrence and survival in upper tract urothelial
More informationLymphadenectomy in RCC: Yes, No, Clinical Trial?
Lymphadenectomy in RCC: Yes, No, Clinical Trial? Viraj Master MD PhD FACS Professor Associate Chair for Clinical Affairs and Quality Director of Clinical Research Unit Department of Urology Emory University
More informationTemporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008
Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,
More informationThe Karakiewicz Nomogram Is the Most Useful Clinical Predictor for Survival Outcomes in Patients With Localized Renal Cell Carcinoma
The Karakiewicz Nomogram Is the Most Useful Clinical Predictor for Survival Outcomes in Patients With Localized Renal Cell Carcinoma Min-Han Tan, MBBS, MRCP 1,2,3 ; Huihua Li, PhD 4 ; Caroline Victoria
More information1. Introduction. Department of Urology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba , Japan 2
Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 754382, 6 pages doi:10.1155/2011/754382 Clinical Study Development and External Validation of a Nomogram Predicting the Probability
More informationBest Papers. F. Fusco
Best Papers UROLOGY F. Fusco Best papers - 2015 RP/RT Oncological outcomes RP/RT IN ct3 Utilization trends RP/RT Complications Evolving role of elnd /Salvage LND This cohort reflects the current clinical
More informationRadical cystectomy for bladder cancer: oncologic outcome in 271 Chinese patients
Original Article : oncologic outcome in 271 Chinese patients Zhi-Ling Zhang, Pei Dong, Yong-Hong Li, Zhuo-Wei Liu, Kai Yao, Hui Han, Zi-Ke Qin and Fang-Jian Zhou Abstract Few large scale studies have reported
More informationNomogram predicted survival of patients with adenocarcinoma of esophagogastric junction
Zhou et al. World Journal of Surgical Oncology (2015) 13:197 DOI 10.1186/s12957-015-0613-7 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Nomogram predicted survival of patients with adenocarcinoma
More informationPrognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous Cell Carcinoma in China
1663 Ivyspring International Publisher Research Paper Journal of Cancer 2016; 7(12): 1663-1667. doi: 10.7150/jca.15216 Prognostic Value of Plasma D-dimer in Patients with Resectable Esophageal Squamous
More informationVictor H. W. Yeung, Yi Chiu, Sylvia S. Y. Yu, W. H. Au, and Steve W. H. Chan
The Scientific World Journal Volume 23, Article ID 5662, 4 pages http://dx.doi.org/.55/23/5662 Clinical Study Are Preoperative Kattan and Stephenson Nomograms Predicting Biochemical Recurrence after Radical
More informationIs There a Need to Further Subclassify pt2 Renal Cell Cancers as Implemented by the Revised 7th TNM Version?
EUROPEAN UROLOGY 59 (2011) 258 263 available at www.sciencedirect.com journal homepage: www.europeanurology.com Kidney Cancer Is There a Need to Further Subclassify pt2 Renal Cell Cancers as Implemented
More informationPredicting Clinical Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
EUROPEAN UROLOGY 61 (2012) 818 825 available at www.sciencedirect.com journal homepage: www.europeanurology.com Urothelial Cancer Predicting Clinical Outcomes After Radical Nephroureterectomy for Upper
More informationeuropean urology 52 (2007)
european urology 52 (2007) 1428 1437 available at www.sciencedirect.com journal homepage: www.europeanurology.com Kidney Cancer Platelet Count and Preoperative Haemoglobin Do Not Significantly Increase
More informationCONTEMPORARY UPDATE OF PROSTATE CANCER STAGING NOMOGRAMS (PARTIN TABLES) FOR THE NEW MILLENNIUM
RAPID COMMUNICATION CME ARTICLE CONTEMPORARY UPDATE OF PROSTATE CANCER STAGING NOMOGRAMS (PARTIN TABLES) FOR THE NEW MILLENNIUM ALAN W. PARTIN, LESLIE A. MANGOLD, DANA M. LAMM, PATRICK C. WALSH, JONATHAN
More informationEthnic Disparities in the Treatment of Stage I Non-small Cell Lung Cancer. Juan P. Wisnivesky, MD, MPH, Thomas McGinn, MD, MPH, Claudia Henschke, PhD,
Ethnic Disparities in the Treatment of Stage I Non-small Cell Lung Cancer Juan P. Wisnivesky, MD, MPH, Thomas McGinn, MD, MPH, Claudia Henschke, PhD, MD, Paul Hebert, PhD, Michael C. Iannuzzi, MD, and
More informationDepartment of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
www.kjurology.org http://dx.doi.org/10.4111/kju.2014.55.5.321 Original Article - Urological Oncology http://crossmark.crossref.org/dialog/?doi=10.4111/kju.2014.55.5.321&domain=pdf&date_stamp=2014-05-16
More informationLung cancer is a major cause of cancer deaths worldwide.
ORIGINAL ARTICLE Prognostic Factors in 3315 Completely Resected Cases of Clinical Stage I Non-small Cell Lung Cancer in Japan Teruaki Koike, MD,* Ryosuke Tsuchiya, MD, Tomoyuki Goya, MD, Yasunori Sohara,
More informationThe prognosis of different distant metastases pattern in prostate cancer: A population based retrospective study
Received: 21 September 2017 Accepted: 22 January 2018 DOI: 10.1002/pros.23492 ORIGINAL ARTICLE The prognosis of different distant metastases pattern in prostate cancer: A population based retrospective
More informationExtranodal Extension Is a Powerful Prognostic Factor in Bladder Cancer Patients with Lymph Node Metastasis
EUROPEAN UROLOGY 64 (2013) 837 845 available at www.sciencedirect.com journal homepage: www.europeanurology.com Bladder Cancer Extranodal Extension Is a Powerful Prognostic Factor in Bladder Cancer Patients
More informationLog odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection
Original Article Log odds of positive lymph nodes is a novel prognostic indicator for advanced ESCC after surgical resection Mingjian Yang 1,2, Hongdian Zhang 1,2, Zhao Ma 1,2, Lei Gong 1,2, Chuangui Chen
More informationThe Prognostic Value of Ratio-Based Lymph Node Staging in Resected Non Small-Cell Lung Cancer
Original Article The Prognostic Value of Ratio-Based Lymph Node Staging in Resected Non Small-Cell Lung Cancer Chen Qiu, MD,* Wei Dong, MD,* Benhua Su, MBBS, Qi Liu, MD,* and Jiajun Du, PhD Introduction:
More informationDevelopment and Internal Validation of a Prostate Health Index Based Nomogram for Predicting Prostate Cancer at Extended Biopsy
Development and Internal Validation of a Prostate Health Index Based Nomogram for Predicting Prostate Cancer at Extended Biopsy Giovanni Lughezzani,*, Massimo Lazzeri, Alessandro Larcher, Giuliana Lista,
More informationAccepted for publication 12 August 2009 S.F.S. and G.G. are currently at Memorial Sloan-Kettering Cancer Center in New York, NY, USA
. JOURNAL COMPILATION 2009 BJU INTERNATIONAL Urological Oncology ASSOCIATION OF AGE WITH OUTCOMES OF UPPER TRACT UROTHELIAL CARCINOMA SHARIAT ET AL. BJUI BJU INTERNATIONAL Advanced patient age is associated
More informationNatural History and Treatment Trends in Hepatocellular Carcinoma Subtypes: Insights From a National Cancer Registry
2015;112:872 876 Natural History and Treatment Trends in Hepatocellular Carcinoma Subtypes: Insights From a National Cancer Registry PETER L. JERNIGAN, MD, KOFFI WIMA, MS, DENNIS J. HANSEMAN, PhD, RICHARD
More informationThe impact of extrahepatic disease among patients undergoing liver-directed therapy for neuroendocrine liver metastasis
Received: 1 May 2017 Accepted: 23 May 2017 DOI: 10.1002/jso.24727 RESEARCH ARTICLE The impact of extrahepatic disease among patients undergoing liver-directed therapy for neuroendocrine liver metastasis
More informationResearch Article Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma
Sarcoma, Article ID 902620, 8 pages http://dx.doi.org/10.1155/2014/902620 Research Article Clinical Features and Outcomes Differ between and Osteosarcoma Sheila Thampi, 1 Katherine K. Matthay, 1 W. John
More informationGUIDELINES ON PENILE CANCER
GUIDELINES ON PENILE CANCER (Text update April 2010) G. Pizzocaro, F. Algaba, S. Horenblas, E. Solsona, S. Tana, H. Van Der Poel, N. Watkin 78 Penile Cancer Eur Urol 2010 Jun;57(6):1002-12 Introduction
More informationAnalysis of the outcome of young age tongue squamous cell carcinoma
Jeon et al. Maxillofacial Plastic and Reconstructive Surgery (2017) 39:41 DOI 10.1186/s40902-017-0139-8 Maxillofacial Plastic and Reconstructive Surgery RESEARCH Open Access Analysis of the outcome of
More informationDevelopment and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy
Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy Giuseppe Simone, Marco Bianchi, Diana Giannarelli, Siamak Daneshmand, Rocco
More informationImpaired Chronotropic Response to Exercise Stress Testing in Patients with Diabetes Predicts Future Cardiovascular Events
Diabetes Care Publish Ahead of Print, published online May 28, 2008 Chronotropic response in patients with diabetes Impaired Chronotropic Response to Exercise Stress Testing in Patients with Diabetes Predicts
More informationTumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma
ONCOLOGY LETTERS 9: 125-130, 2015 Tumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma KEIICHI ITO 1, KENJI SEGUCHI 1, HIDEYUKI SHIMAZAKI 2, EIJI TAKAHASHI
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationDesmoplastic Melanoma: Surgical Management and Adjuvant Therapy
Desmoplastic Melanoma: Surgical Management and Adjuvant Therapy Dale Han, MD Assistant Professor Department of Surgery Section of Surgical Oncology No disclosures Background Desmoplastic melanoma (DM)
More informationGUIDELINEs ON PENILE CANCER
GUIDELINEs ON PENILE CANCER (update April 2010) G. Pizzocaro, F. Algaba, S. Horenblas, E. Solsona, S. Tana, H. Van Der Poel, N. Watkin Eur Urol 2010, doi:10.1016/j.eururo.2010.01.039 Introduction Over
More informationRacial Disparities and Socioeconomic Status in Men Diagnosed With Testicular Germ Cell Tumors
Racial Disparities and Socioeconomic Status in Men Diagnosed With Testicular Germ Cell Tumors A Survival Analysis Maxine Sun, BSc 1 ; Firas Abdollah, MD 1,2 ; Daniel Liberman, MD 1,3 ; Al a Abdo, MD 1,3
More informationRole and extension of lymph node dissection in kidney, bladder and prostate cancer. Omar Ghanem (PGY3 ) Moderator: Dr A. Noujem 30 th March 2017
Role and extension of lymph node dissection in kidney, bladder and prostate cancer Omar Ghanem (PGY3 ) Moderator: Dr A. Noujem 30 th March 2017 Bladder Cancer LN dissection in Bladder cancer 25% of patients
More informationState-of-the-art: vision on the future. Urology
State-of-the-art: vision on the future Urology Francesco Montorsi MD FRCS Professor and Chairman Department of Urology San Raffaele Hospital Vita-Salute San Raffaele University Milan, Italy Disclosures
More informationSalvage prostatectomy for post-radiation adenocarcinoma with treatment effect: Pathological and oncological outcomes
ORIGINAL RESEARCH Salvage prostatectomy for post-radiation adenocarcinoma with treatment effect: Pathological and oncological outcomes Michael J. Metcalfe, MD ; Patricia Troncoso, MD 2 ; Charles C. Guo,
More informationRadical Prostatectomy:
Overtreatment and undertreatment Radical Prostatectomy: An Emerging Standard of Care for High Risk Prostate Cancer Matthew R. Cooperberg, MD,MPH UCSF Radiation Oncology Update San Francisco, CA April 2,
More informationCreating prognostic systems for cancer patients: A demonstration using breast cancer
Received: 16 April 2018 Revised: 31 May 2018 DOI: 10.1002/cam4.1629 Accepted: 1 June 2018 ORIGINAL RESEARCH Creating prognostic systems for cancer patients: A demonstration using breast cancer Mathew T.
More informationRESEARCH ARTICLE. Comparison between Overall, Cause-specific, and Relative Survival Rates Based on Data from a Population-based Cancer Registry
DOI:http://dx.doi.org/.734/APJCP.22.3..568 RESEARCH ARTICLE Comparison between Overall, Cause-specific, and Relative Survival Rates Based on Data from a Population-based Cancer Registry Mai Utada *, Yuko
More informationPeritoneal Involvement in Stage II Colon Cancer
Anatomic Pathology / PERITONEAL INVOLVEMENT IN STAGE II COLON CANCER Peritoneal Involvement in Stage II Colon Cancer A.M. Lennon, MB, MRCPI, H.E. Mulcahy, MD, MRCPI, J.M.P. Hyland, MCh, FRCS, FRCSI, C.
More informationPrognostic value of visceral pleura invasion in non-small cell lung cancer q
European Journal of Cardio-thoracic Surgery 23 (2003) 865 869 www.elsevier.com/locate/ejcts Prognostic value of visceral pleura invasion in non-small cell lung cancer q Jeong-Han Kang, Kil Dong Kim, Kyung
More informationSurvival Prediction Models for Estimating the Benefit of Post-Operative Radiation Therapy for Gallbladder Cancer and Lung Cancer
Survival Prediction Models for Estimating the Benefit of Post-Operative Radiation Therapy for Gallbladder Cancer and Lung Cancer Jayashree Kalpathy-Cramer PhD 1, William Hersh, MD 1, Jong Song Kim, PhD
More informationThe Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.
30 th Congress of the European Society of Pathology Tuesday, September 11, 2018 The Depth of Tumor Invasion is Superior to 8 th AJCC/UICC Staging System to Predict Patients Outcome in Radical Cystectomy.
More informationCauses of death in men with prostate cancer: an analysis of men from the Thames Cancer Registry
Causes of death in men with prostate cancer: an analysis of 5 men from the Thames Cancer Registry Simon Chowdhury, David Robinson, Declan Cahill*, Alejo Rodriguez-Vida, Lars Holmberg and Henrik Møller
More informationPrognostic value of tumor length in predicting survival for patients with esophageal cancer
Original Article Prognostic value of tumor length in predicting survival for patients with esophageal cancer Haijing Wang 1, Liangwen Bi 2, Lizhen Zhang 2, Weiyong Zhao 2, Min Yang 1,3, Xinchen Sun 1 1
More informationA comparison of the proposed classifications for the revision of N descriptors for non-small-cell lung cancer
European Journal of Cardio-Thoracic Surgery 49 (2016) 580 588 doi:10.1093/ejcts/ezv134 Advance Access publication 18 April 2015 ORIGINAL ARTICLE Cite this article as: Lee GD, Kim DK, Moon DH, Joo S, Hwang
More informationMarcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans R. J. Elbers, MD, PhD; and Jules M. M. van den Bosch, MD, PhD, FCCP
Prognostic Assessment of 2,361 Patients Who Underwent Pulmonary Resection for Non-small Cell Lung Cancer, Stage I, II, and IIIA* Marcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans
More informationClinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
Diseases of the Esophagus (2008) 21, 596 600 DOI: 10.1111/j.1442-2050.2008.00817.x Original article Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma:
More informationUnderstanding the risk of recurrence after primary treatment for prostate cancer. Aditya Bagrodia, MD
Understanding the risk of recurrence after primary treatment for prostate cancer Aditya Bagrodia, MD Aditya.bagrodia@utsouthwestern.edu 423-967-5848 Outline and objectives Prostate cancer demographics
More informationRadical Cystectomy in the Treatment of Bladder Cancer: Oncological Outcome and Survival Predictors
ORIGINAL ARTICLE Radical Cystectomy in the Treatment of Bladder Cancer: Oncological Outcome and Survival Predictors Chen-Hsun Ho, 1,2 Chao-Yuan Huang, 1 Wei-Chou Lin, 3 Shih-Chieh Chueh, 1 Yeong-Shiau
More informationTreatment Strategy for Non-curative Resection of Early Gastric Cancer. Jun Haneg Lee. Sungkyunkwan University, Samsung Medical Center, Seoul Korea
Treatment Strategy for Non-curative Resection of Early Gastric Cancer Jun Haneg Lee. Sungkyunkwan University, Samsung Medical Center, Seoul Korea Classic EMR/ESD data analysis style Endoscopic resection
More informationHeterogeneity in high-risk prostate cancer treated with high-dose radiation therapy and androgen deprivation therapy
Cagney et al. BMC Urology (2017) 17:60 DOI 10.1186/s12894-017-0250-2 RESEARCH ARTICLE Heterogeneity in high-risk prostate cancer treated with high-dose radiation therapy and androgen deprivation therapy
More informationHierro-Majadahonda, Universidad Aut ó noma de Madrid, Madrid, Spain,
BJUI BJU INTERNATIONAL Impact of tumour location versus multifocality in patients with upper tract urothelial carcinoma treated with nephroureterectomy and bladder cuff excision: a homogeneous series without
More informationDebate: Lymphadenectomy is Important in mrcc, CON P. Mulder, M.D., Ph.D. JJ. Patard, MD, Ph.D.
Debate: Lymphadenectomy is Important in mrcc, CON P. Mulder, M.D., Ph.D. JJ. Patard, MD, Ph.D.. Eighth European International Kidney Cancer Symposium Budapest 03-04 May 2013 The role of LND In organ confined
More informationIntroduction. Original Article
bs_bs_banner International Journal of Urology (2015) 22, 363 367 doi: 10.1111/iju.12704 Original Article Prostate-specific antigen level, stage or Gleason score: Which is best for predicting outcomes after
More informationJohan Lyth, J Hansson, C Ingvar, E Mansson-Brahme, P Naredi, U Stierner, G Wagenius and C Lindholm. Linköping University Post Print
Prognostic subclassifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark s level of invasion: results of a population-based study from the Swedish Melanoma Register Johan
More informationSurgical resection improves survival in pancreatic cancer patients without vascular invasion- a population based study
Original article Annals of Gastroenterology (2013) 26, 346-352 Surgical resection improves survival in pancreatic cancer patients without vascular invasion- a population based study Subhankar Chakraborty
More informationJ Clin Oncol 28: by American Society of Clinical Oncology INTRODUCTION
VOLUME 28 NUMBER 2 JANUARY 0 200 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T Evaluating Overall Survival and Competing Risks of Death in Patients With Localized Renal Cell Carcinoma Using
More informationLymph node ratio is an important and independent prognostic factor for patients with stage III melanoma.
Thomas Jefferson University Jefferson Digital Commons Department of Surgery Faculty Papers Department of Surgery 1-1-2012 Lymph node ratio is an important and independent prognostic factor for patients
More informationThyroid Cancer: When to Treat? MEGAN R. HAYMART, MD
Thyroid Cancer: When to Treat? MEGAN R. HAYMART, MD ASSOCIATE PROFESSOR OF MEDICINE UNIVERSITY OF MICHIGAN MICHIGAN AACE 2018 ANNUAL MEETING Thyroid Cancer: When Not to Treat? FOCUS WILL BE ON LOW-RISK
More informationPrognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China
www.springerlink.com Chin J Cancer Res 23(4):265 270, 2011 265 Original Article Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai,
More informationXiang Hu*, Liang Cao*, Yi Yu. Introduction
Original Article Prognostic prediction in gastric cancer patients without serosal invasion: comparative study between UICC 7 th edition and JCGS 13 th edition N-classification systems Xiang Hu*, Liang
More information