Pancreatic Cytopathology: The Solid Neoplasms
|
|
- Cornelius Smith
- 5 years ago
- Views:
Transcription
1 Pancreatic Cytopathology: The Solid Neoplasms Syed Z. Ali, M.D. Professor of Pathology and Radiology Director of Cytopathology The Johns Hopkins Hospital Baltimore, Maryland Pancreatic Cytopathology: Past, Present And Future Fine Needle Aspiration of the Pancreas 60-80% of FNA diagnoses are MALIGNANT % are ACA Pancreatic Cytopathology: Past, Present And Future Pancreatic Cancer New Cases: 43,920 Deaths: 37,390 (85%) 4 th leading cause of cancer-related death in both sexes 4% live 5 years after the diagnosis 80-85% present with advanced unresectable disease *NCI 2012 SEER Cancer Statistics Review 1
2 Pancreatic Cytopathology The Fear Factor 3 rd most common site where normal cells are misinterpreted as neoplastic/malignant ~ 10% of Whipple surgeries performed for presumed malignancy (clinical and/or FNA findings) reveal benign disease on histopathology ~ 25% of these have autoimmune pancreatitis (AIP) or lymphoplasmacytic sclerosing pancreatitis (LSP) Cytopathology Of The Pancreas - A Multi Disciplinary Approach Surgeon Radiologist Clinical Findings Imaging Chemistry Cytomorphology Gastroenterologist Cytopathologist 2
3 Solid Neoplasms Of The Pancreas [Exocrine Pancreas] Ductal Carcinoma Variants Acinar Cell Carcinoma Pancreatoblastoma Solid Pseudopapillary Neoplasm Ductal Adenocarcinoma 3
4 Adenocarcinoma Cytologic Grading Well - Moderate - Poor - Flat Sheets More crowded 3-D Tissue fragments Pleomorphism (Focal) Hypochromatic Micronucleoli More single cells Pleomorphism (Extensive) Hyperchromatic Macronucleoli Why do we grade? Fine-tune our diagnosis and differential diagnoses Optimize cancer therapy (if PD, neoadjuvant therapy is often considered) Prognostication (indicator of poor outcome in resectable disease) Grading should preferably be two tiered (not five) 4
5 Immunoperoxidase Profile CK 7 +, CK 20 - CEA +, CA MUC1 +, MUC4 + MUC2- (Cf IPMN And Mucinous Cystic Neo) Chromogranin+ (Focal, Scattered Cells) DPC4 (SMAD4)- (Loss/Inactivation-55%) Other Markers Mesothelin Fascin 5
6 Ductal Carcinoma - Variants Mucinous Non-cystic Adenocarcinoma (Colloid) Signet-ring Cell Carcinoma Medullary Carcinoma Adenosquamous Carcinoma Undifferentiated Carcinoma With Osteoclast-like Giant Cells Anaplastic (Undifferentiated) Carcinoma Mucinous Non-cystic Adenocarcinoma (Colloid) Majority arise in association with intestinal-type IPMN Overall prognosis better than conventional tubular ductal ACA (not stage-adjusted) 6
7 Signet-ring Cell Carcinoma Highly aggressive and rare cancer Rule out metastasis to the pancreas (gastric, breast lobular) Medullary Carcinoma Associated with microsatellite instability, colonic adenocarcinoma Usually no KRAS mutations, 20% have inactivation of DNA mismatch repair system Adenosquamous Cell Carcinoma 7
8 Poorer Prognosis - median overall survival 10 mo The proportion of squamous differentiation is often not associated with median overall survival (< 30% versus > or = 30%) Undifferentiated Carcinoma with Osteoclast-like Giant Cells Often a component of an in-situ or invasive ACA Poor prognosis (< one year) 8
9 Anaplastic (undifferentiated) Carcinoma Extremely bad prognosis Rule out metastasis to the pancreas (melanoma) Acinar Cell Carcinoma 9
10 Trypsin (100%), lipase (80%), chymotrypsin (40%), and amylase (30%) Focal neuroendocrine marker immunoexpression (upto 43%) Alterations in the KRAS oncogene and in the SMAD4 (DPC4) and p53 tumor suppressor genes are usually not seen Overall median survival 19 months (age, size and stage) 10
11 Solid-Pseudopapillary Neoplasm 11
12 Beta-Catenin CD99 Endocrine Pancreas Pancreatic Neuroendocrine Tumor (PanNet) High-grade NE Carcinoma Small cell type Large cell type Pancreatic Neuroendocrine Tumor (PanNet) 12
13 NE markers +, CK7 -, PAX 8 + Size (>0.5cm are malignant) Grading with Ki-67 % (G1 0-2%, G2 3-20%, G3->20% or NE Carcinoma) 13
14 14
Neoplasias Quisticas del Páncreas
SEAP -Aproximación Práctica a la Patología Gastrointestinal- Madrid, 26 de mayo, 2006 Neoplasias Quisticas del Páncreas Gregory Y. Lauwers, M.D. Director, Service Massachusetts General Hospital Harvard
More informationSelect problems in cystic pancreatic lesions
Disclosure Select problems in cystic pancreatic lesions Five Prime Therapeutics shareholder Adicet Bio shareholder Bristol-Meyer Squibb advisory board grace.kim@ucsf.edu Pancreatic cystic lesions Intraductal
More informationPancreatic Cystic Lesions 원자력병원
Pancreatic Cystic Lesions 원자력병원 박선 후 Lines of cellular differentiation Ductal Acinar Undetermined Ductal adenocarcinoma Serous/ mucinous tumor Intraductal papillary mucinous neoplasm Acinar cell carcinoma
More informationCytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics. Mercè Jordà, University of Miami
Cytological Sub-classification of Lung Cancer: Morphologic and Molecular Characteristics Mercè Jordà, University of Miami Mortality Lung cancer is the most frequent cause of cancer incidence and mortality
More information40th European Congress of Cytology Liverpool, UK, 2-5 th October 2016
40th European Congress of Cytology Liverpool, UK, 2-5 th October 2016 EUS FNA of abdominal organs: An approach to reporting and triage for ancillary testing Date and time: Sunday 2 nd October 2016 15.00-16.30
More informationAppendix 4: WHO Classification of Tumours of the pancreas 17
S3.01 The WHO histological tumour type must be recorded. CS3.01a The histological type of the tumour should be recorded based on the current WHO classification 17 (refer to Appendices 4-7). Appendix 4:
More informationState of the Art Symposium
State of the Art Symposium Syed Z. Ali, MD There is no disclosure necessary Martha B. Pitman, MD There is no disclosure necessary Lester Layfield, MD There is no disclosure necessary Joseph Herman, MD
More informationOutline 11/2/2017. Pancreatic EUS-FNA general aspects. Cytomorphologic features of solid neoplasms/lesions of the pancreas
ENDOSCOPIC ULTRASOUND GUIDED-FINE NEEDLE ASPIRATION CYTOLOGY OF PANCREAS Khalid Amin M.D. Assistant Professor Department of Laboratory Medicine and Pathology University of Minnesota Outline Pancreatic
More informationPancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA
Pancreatitis: A Potential Pitfall in Endoscopic Ultrasound Guided Pancreatic FNA Jack Yang, MD Department of Pathology, Medical University of South Carolina Objectives Understand the indication of EUS
More informationAnatomy of the biliary tract
Harvard-MIT Division of Health Sciences and Technology HST.121: Gastroenterology, Fall 2005 Instructors: Dr. Jonathan Glickman Anatomy of the biliary tract Figure removed due to copyright reasons. Biliary
More informationTeam approach is essential incorporating: radiology, gastroenterology, surgery and pathology Successful performance is operator dependent
Committee V Post Brushing and FNA Testing Managment Options Daniel Kurtycz, M.D. Chair Committee V Committee V - Post brushing and FNA management options Team approach is essential incorporating: radiology,
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationStandardized Terminology in Pancreatobiliary Cytology: The Papanicolaou Society Guidelines
Standardized Terminology in Pancreatobiliary Cytology: The Papanicolaou Society Guidelines Barbara Ann Centeno. M.D. Vice-Chair, Clinical Services, Anatomic Pathology Assistant Chief, Pathology Service
More informationACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts
ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts Grace H. Elta, MD, FACG 1, Brintha K. Enestvedt, MD, MBA 2, Bryan G. Sauer, MD, MSc, FACG (GRADE Methodologist) 3 and Anne Marie Lennon,
More informationCase 1. Case 1: EUS Report 5/1/2017. Interesting Cases of Pancreatic Masses
Interesting Cases of Pancreatic Masses Martha Bishop Pitman, MD Professor of Pathology Harvard Medical School Director of Cytopathology Massachusetts General Hospital Boston, MA MASSACHUSETTS GENERAL PHYSICIANS
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationAn Approach to Pancreatic Cysts. Introduction
An Approach to Pancreatic Cysts Nalini M. Guda, MD Aurora St. Luke s Medical Center, Milwaukee Clinical Adjunct Professor of Medicine, University of Wisconsin School of Medicine and Public Health Introduction
More informationEUS-guided FNAB. Differential Diagnosis 5/1/2017. EUS-FNA of Solid and Cystic Lesions:
EUS-FNA of Solid and Cystic Lesions: Part 1: Solid Masses Martha Bishop Pitman, M.D. Director, Cytopathology Massachusetts General Hospital Professor of Pathology Harvard Medical School Boston, MA EUS-guided
More informationCYTOLOGY OF EUS- GUIDED FNA OF THE PANCREAS AND THE UPPER GI TRACT
CYTOLOGY OF EUS- GUIDED FNA OF THE PANCREAS AND THE UPPER GI TRACT Barbara A. Centeno, M.D. Vice-Chair, Clinical Services Assistant Chief of Pathology Director of Cytopathology Department of Anatomic Pathology/Moffitt
More informationEnterprise Interest Nothing to declare
Enterprise Interest Nothing to declare Update of mixed tumours of the GI tract, the pancreas and the liver Introduction to the concept of mixed tumours and clinical implication Jean-Yves SCOAZEC Surgical
More informationPancreatic intraepithelial
Pancreatic intraepithelial neoplasia (PanIN) Markéta Hermanová St. Anne s University Hospital Brno Faculty of Medicine, Masaryk University Precursor lesions of invasive pancreatic cancer Pancreatic intraepithelial
More informationPancreatico-biliary cytology: a practical approach to diagnosis. Corina Cotoi
Pancreatico-biliary cytology: a practical approach to diagnosis Corina Cotoi Pancreatico-biliary lesions Solid: Ductal adenocarcinoma Cholangiocarcinoma Acinar cell carcinoma Neuroendocrine tumour / carcinoma
More informationEvaluation and Management of Cystic Lesions of the Pancreas: When to Resect, When to Follow and When to Forget
Evaluation and Management of Cystic Lesions of the Pancreas: When to Resect, When to Follow and When to Forget Randall Brand, MD Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition
More informationROSE in EUS guided FNA of Pancreatic Lesions
ROSE in EUS guided FNA of Pancreatic Lesions Guy s Hospital, London, 16 April 2018 Laxmi Batav Imperial College NHS Trust Imperial College NHS Trust Cytology Workload Cervical Cytology 57,500 (decreases
More informationKenneth D. Chi, MD Medical Director GI Lab Advocate Lutheran General Hospital
Kenneth D. Chi, MD Medical Director GI Lab Advocate Lutheran General Hospital Advances in Digestive Health for the Primary Care Physician Symposium May 2, 2015 None Case Presentation Types of Pancreatic
More informationAdenocarcinoma of the pancreas
Adenocarcinoma of the pancreas SEMINARS IN DIAGNOSTIC PATHOLOGY 31 (2014) 443 451 Ralph H.Hruban, MD, David S. Klimstra, MD Paola Parente Anatomia Patologica Casa Sollievo della Sofferenza San Giovanni
More informationPOORLY DIFFERENTIATED, HIGH GRADE AND ANAPLASTIC CARCINOMAS: WHAT IS EVERYONE TALKING ABOUT?
POORLY DIFFERENTIATED, HIGH GRADE AND ANAPLASTIC CARCINOMAS: WHAT IS EVERYONE TALKING ABOUT? AGGRESSIVE THYROID CANCERS PAPILLARY CARCINOMA CERTAIN SUBTYPES POORLY DIFFERENTIATED CARCINOMA HIGH GRADE DIFFERENTIATED
More informationCarcinoma mammario: le istologie non frequenti. Valentina Guarneri Università di Padova IOV-IRCCS
Carcinoma mammario: le istologie non frequenti Valentina Guarneri Università di Padova IOV-IRCCS Histological diversity of breast adenocarcinomas Different histological types are defined according to specific
More informationPancreatic Cancer: The ABCs of the AJCC and WHO
Pancreatic Cancer: The ABCs of the AJCC and WHO Aatur D. Singhi, MD PhD Assistant Professor University of Pittsburgh Medical Center Department of Pathology singhiad@upmc.edu Case presentation Objectives
More informationCase #1 FNA of nodule in left lobe of thyroid in 67 y.o. woman
Challenging Cases Manon Auger M.D., F.R.C.P. (C) Professor, Department of Pathology McGill University Director, Cytopathology Laboratory McGill University it Health Center Case #1 FNA of nodule in left
More information5/21/2018. An Update on Pancreas Neoplasms. Arief Suriawinata, M.D. Lines of Differentiation in Pancreatic Neoplasms
An Update on Pancreas Neoplasms Arief Suriawinata, M.D. Professor of Pathology and Laboratory Medicine Geisel School of Medicine at Dartmouth Department of Pathology and Laboratory Medicine Dartmouth-Hitchcock
More informationRadiology Pathology Conference
Radiology Pathology Conference Nadia F. Yusaf, M.D. PGY-3 1/29/2010 Presentation material is for education purposes only. All rights reserved. 2010 URMC Radiology Page 1 of 90 Case 1 60 year- old man presents
More informationHepatobiliary and Pancreatic Malignancies
Hepatobiliary and Pancreatic Malignancies Gareth Eeson MD MSc FRCSC Surgical Oncologist and General Surgeon Kelowna General Hospital Interior Health Consultant, Surgical Oncology BC Cancer Agency Centre
More informationPancreatic Cystic Neoplasms: Guidelines and beyond
Pancreatic Cystic Neoplasms: Guidelines and beyond Kenneth J. Chang, MD, FACG, FASGE Executive Director, Comprehensive Digestive Disease Center Professor and Chief, Gastroenterology Vincent & Anna Kong
More informationNon Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק
Non Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק 26.06.09 Lecture outlines WHO histological classification Macro/Micro assessment Early diagnosis Minimal pathology Main subtypes SCC, AdCa, LCLC
More informationBuilding On The Best A Review and Update on Bethesda Thyroid 2017
Building On The Best A Review and Update on Bethesda Thyroid 2017 Syed Z. Ali, MD, FRCPath, FIAC Professor of Pathology and Radiology The Johns Hopkins Hospital, Baltimore, Maryland USA TBSRTC Diagnostic
More informationPancreas (Exocrine) Protocol applies to all carcinomas of the exocrine pancreas.
Pancreas (Exocrine) Protocol applies to all carcinomas of the exocrine pancreas. Protocol revision date: January 2005 Based on AJCC/UICC TNM, 6 th edition Procedures Cytology (No Accompanying Checklist)
More informationSuspicious Cytologic Diagnostic Category in Endoscopic Ultrasound-Guided FNA of the Pancreas: Follow-Up and Outcomes
Suspicious Cytologic Diagnostic Category in Endoscopic Ultrasound-Guided FNA of the Pancreas: Follow-Up and Outcomes Evan A. Alston, MD 1 ; Sejong Bae, PhD 2 ; and Isam A. Eltoum, MD, MBA 1 BACKGROUND:
More informationEUS-guided FNAB. Differential Diagnosis 3/14/2018. EUS-FNA of Solid and Cystic Lesions: Part 1: Solid Masses
EUS-FNA of Solid and Cystic Lesions: Part 1: Solid Masses Martha Bishop Pitman, M.D. Director, Cytopathology Massachusetts General Hospital Professor of Pathology Harvard Medical School Boston, MA EUS-guided
More informationThe role of endoscopy in the diagnosis and treatment of cystic pancreatic neoplasms
The role of endoscopy in the diagnosis and treatment of cystic pancreatic neoplasms CYSTIC LESIONS AND FLUID COLLECTIONS OF THE PANCREAS Their pathology ranges from pseudocysts and pancreatic necrosis
More informationJoseph Misdraji, M.D. GI pathology Unit Massachusetts General Hospital
Joseph Misdraji, M.D. GI pathology Unit Massachusetts General Hospital jmisdraji@partners.org Low-grade appendiceal mucinous neoplasm (LAMN) High-grade appendiceal mucinous neoplasm (HAMN) Adenocarcinoma
More information2007 Multiple Primary and
2007 Multiple Primary and Histology Coding Rules Beyond the Basics Florida Cancer Data System Annual Conference Tampa, FL July 26,2007 Steven Peace, CTR Westat Carol Johnson, CTR NCI SEER Peggy Adamo,
More informationNCI Thyroid FNA State of the Science Conference. The Bethesda System For Reporting Thyroid Cytopathology
The Bethesda System For Reporting Thyroid Cytopathology Towards a Uniform Terminology With Management Guidelines NCI Thyroid FNA State of the Science Conference Bethesda, MD October 22-23, 2007 154 registrants
More informationPancreas Quizzes c. Both A and B a. Directly into the blood stream (not using ducts)
Pancreas Quizzes Quiz 1 1. The pancreas produces hormones. Which type of hormone producing organ is the pancreas? a. Endocrine b. Exocrine c. Both A and B d. Neither A or B 2. Endocrine indicates hormones
More informationImpact of immunostaining of pulmonary and mediastinal cytology
Impact of immunostaining of pulmonary and mediastinal cytology Harman Sekhon MD, PhD Director of Cytopathology Head of Ottawa-site Ontario Tumour Bank June 20, 2014 Disclaimer Pfizer: Honorarium-Advisory
More informationObjectives. Pancreatic Cysts. Benefits and Limitations of the Cytologic Assessment of Cystic Pancreatic Lesions and Masses
Benefits and Limitations of the Cytologic Assessment of Cystic Pancreatic Lesions and Masses Michelle D. Reid, MD, MSc Associate 1/24/15 Professor Director of Cytology - EUHM Michelle D Reid MD, MS Emory
More informationThe pathology of pancreas
5. Practice The pathology of pancreas 2017/2018. 2nd semester MACROSCOPY- MICROSCOPY THE STRUCTURE OF PANCREAS Exocrine: 80-85% Enzymes in the zymogenic granules of acinar cells: trypsin, chymotrypsin,
More informationMCR: MANAGEMENT OF 2018 CHANGES. By: Maricarmen Traverso-Ortiz MPH, CGG, CTR
MCR: MANAGEMENT OF 2018 CHANGES By: Maricarmen Traverso-Ortiz MPH, CGG, CTR LEARNING OBJECTIVES Discuss a summary of the new changes for 2018 Overview of how the Maryland Cancer Registry is managing and
More informationGOBLET CELL CARCINOID. Hanlin L. Wang, MD, PhD University of California Los Angeles
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationGOBLET CELL CARCINOID
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationManagement A Guideline Based Approach to the Incidental Pancreatic Cysts. Common Cystic Pancreatic Neoplasms.
Management 2016 A Guideline Based Approach to the Incidental Pancreatic Cysts ISMRM 2016 Masoom Haider, MD, FRCP(C) Professor of Radiology, University of Toronto Clinician Scientist, Ontario Institute
More informationPatient History. A 58 year old man presents with a 16 mm cyst in the pancreatic tail. The cyst is unilocular with a thick wall and no mural nodule.
Case 1 Martha Bishop Pitman, MD Director of Cytopathology Massachusetts General Hospital Associate Professor of Pathology Harvard Medical School Boston, MA Patient History A 58 year old man presents with
More informationThyroid follicular neoplasms in cytology. Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia
Thyroid follicular neoplasms in cytology Ulrika Klopčič Institute of Oncology, Department of Cytopathology, Ljubljana, Slovenia Lecture overview importance of FNAB in assessing thyroid lesions follicular
More informationUpdate on Thyroid FNA The Bethesda System. Shikha Bose M.D. Associate Professor Cedars Sinai Medical Center
Update on Thyroid FNA The Bethesda System Shikha Bose M.D. Associate Professor Cedars Sinai Medical Center Thyroid Nodules Frequent occurrence Palpable: 4-7% of adults Ultrasound: 10-31% Majority benign
More informationNeuroendocrine tumors of GI and Pancreatobiliary tracts. N. Volkan Adsay, MD
Neuroendocrine tumors of GI and Pancreatobiliary tracts N. Volkan Adsay, MD New (2017) WHO WHO 2017 (endocrine book; for pancreas) WHO 2017 (endocrine book; for pancreas) PD-NE ca WD-NE Tumor Intended
More informationBiliary Tract Neoplasia: A Cyto-histologic Review. Michelle Reid, MD, MSc Professor of Pathology Director of Cytopathology Emory University Hospital
Biliary Tract Neoplasia: A Cyto-histologic Review Michelle Reid, MD, MSc Professor of Pathology Director of Cytopathology Emory University Hospital Bile Duct Brushings (BDB) BDBs are the initial diagnostic
More informationStandardization of Nomenclature
Standardized Terminology and Nomenclature for Pancreaticobiliary Cytopathology from the Papanicolaou Society of Cytopathology Lester J. Layfield, M.D. Professor and Chair University of Missouri Pathology
More informationCollecting Cancer Data: Pancreas
Collecting Cancer Data: Pancreas NAACCR 2011 2012 Webinar Series 1/5/2012 Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this
More informationPancreatic Cysts. Darius C. Desai, MD FACS St. Luke s University Health Network
Pancreatic Cysts Darius C. Desai, MD FACS St. Luke s University Health Network None Disclosures Incidence Widespread use of cross sectional imaging Seen in over 2% of patients having abdominal imaging
More informationOther Sites. Table 2 Continued. MPH Rules 11/8/07. NAACCR Webinar Series 1
MPH s 11/8/07 Other s 1 Table 2 Continued Use this two-page table to select combination histology codes. Compare the terms in the diagnosis to the terms in Columns 1 and 2. If the terms match, code the
More information3/23/2017. Differentiation: Differentiation: Immunohistochemistry. Well Differentiated vs. Poorly Differentiated Neuroendocrine Neoplasms
Disclosure Statement When Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms Arthur Purdy Stout Society March 5, 2017 Dr. Klimstra receives royalty payments
More informationBasement membrane in lobule.
Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.
More informationWorkshop 9. Cytopathology of Solid and Cystic Neoplasms of the Pancreas: Everything You Need To Know For Daily Practice.
Workshop 9 Cytopathology of Solid and Cystic Neoplasms of the Pancreas: Everything You Need To Know For Daily Practice Michelle Reid, MD Momin Siddiqui, MD,FIAC There are no disclosures necessary. Cytopathology
More informationDIAGNOSTIC CHALLENGES Pancreas FNAB. Dr. M. Weir Oct 2017
DIAGNOSTIC CHALLENGES Pancreas FNAB Dr. M. Weir Oct 2017 CONFLICT OF INTEREST DISCLOSURE I have not had in the past 3 years, a financial interest, arrangement or affiliation with one or more organizations
More informationGOBLET CELL CARCINOID. Hanlin L. Wang, MD, PhD University of California Los Angeles
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles hanlinwang@mednet.ucla.edu Goblet cell carcinoid (GCC) is a unique type of mixed endocrine-exocrine neoplasm, almost exclusively
More informationDIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION
Follicular-patterned thyroid lesions, WC Faquin 1 DIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION William C. Faquin, M.D., Ph.D Department of Pathology, Massachusetts
More informationEffective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific
Effective January 1, 2018 codes, behaviors and terms are site specific /N 8551/3 Acinar adenocarcinoma (C34. _) Lung primaries diagnosed prior to 1/1/2018 use code 8550/3 For prostate (all years) see 8140/3
More information2018 ICD-O-3 Updates in Table Format with Annotation for Reference
Status Histology Description (this may be preferred term or a synonym) Report Comments New term 8010 3 Urachal carcinoma (C65.9, C66.9, C67._, C68._) New term 8013 3 Combined large cell neuroendocrine
More informationEffective January 1, 2018 ICD O 3 codes, behaviors and terms are site specific
Effective January 1, 2018 codes, behaviors and terms are site specific Status /N 8010/3 Urachal carcinoma (C65.9, C66.9, C67. _, C68._) 8013/3 Combined large cell neuroendocrine carcinoma (C34. _, C37.9)
More informationSolid pseudopapillary tumour of the pancreas: Report of five cases
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Solid pseudopapillary tumour of the pancreas: Report of five cases P Srilatha, V Manna, P Kanthilatha Citation P Srilatha, V Manna, P Kanthilatha..
More informationThe Panel Approach to Diagnostics. Lauren Hopson International Product Specialist Cell Marque Corporation
The Panel Approach to Diagnostics Lauren Hopson International Product Specialist Cell Marque Corporation Cell Marque Rocklin, California About Cell Marque: IVD primary antibody manufacturer Distributors
More informationEnrollment Form: Pancreas
Tissue Source Site (TSS) Name: TSS Identifier: _ TSS Unique Patient #: Completed By: Completion Date (MM/DD/YYYY): Form Notes: An Enrollment Form should be completed for each TCGA qualified case upon qualification
More informationSurgical Management of Pancreatic Cancer
I Congresso de Oncologia D Or July 5-6, 2013 Surgical Management of Pancreatic Cancer Michael A. Choti, MD, MBA, FACS Department of Surgery Johns Hopkins University School of Medicine, Baltimore, MD Estimated
More informationList of Available TMAs in the PRN
TMA RPCI_BrainCa01 RPCI_BrCa03 RPCI_BrCa04 RPCI_BrCa05 RPCI_BrCa0 RPCI_BrCa07 RPCI_BrCa08 RPCI_BrCa15 RPCI_BrCa1 RPCI_BrCa17 RPCI_BrCa18 RPCI_BrCa19 RPCI_BrCa20 RPCI_BrCa21 RPCI_BrCa24 RPCI_BrCa25 RPCI_BrCa2
More informationClonal evolution of human cancers
Clonal evolution of human cancers -Pathology-based microdissection and genetic analysis precisely demonstrates molecular evolution of neoplastic clones- Hiroaki Fujii, MD Ageo Medical Laboratories, Yashio
More informationWhen Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms
When Immunostains Can Get You Into Trouble (and how they can help you out): Neuroendocrine Neoplasms Arthur Purdy Stout Society March 5, 2017 David S. Klimstra, MD Chairman, Department of Pathology James
More informationEUS-FNA OF PANCREATIC EXOCRINE TUMORS COMPARISON OF EXPERIENCES WITH PATHOLOGICAL DIAGNOSIS
EUS-FNA OF PANCREATIC EXOCRINE TUMORS COMPARISON OF EXPERIENCES WITH PATHOLOGICAL DIAGNOSIS Vincenzo Canzonieri, M.D. CRO - Aviano National Cancer Institute Dept of Pathology EUS European Cyto-Pathologist
More informationThe Pancreas. Basic Anatomy. Endocrine pancreas. Exocrine pancreas. Pancreas vasculature. Islets of Langerhans. Acinar cells Ductal System
SGNA: Back to Basics Rogelio G. Silva, MD Assistant Clinical Professor of Medicine University of Illinois at Chicago Department of Medicine Division of Gastroenterology Advocate Christ Medical Center GI
More informationCase Scenario 1. Discharge Summary
Case Scenario 1 Discharge Summary A 69-year-old woman was on vacation and noted that she was becoming jaundiced. Two months prior to leaving on that trip, she had had a workup that included an abdominal
More informationPancreatic Cytopathology: A pragmatic approach. By Dr Miguel Perez-Machado MD. PhD. MRCPath Royal Free Hospital
Pancreatic Cytopathology: A pragmatic approach. By Dr Miguel Perez-Machado MD. PhD. MRCPath Royal Free Hospital Indications of Cytology Sampling To document malignancy in patients with malignant appearing
More informationENDOSCOPIC ULTRA SOUND GUIDED FNA OF GI TRACT AND PANCREAS
ENDOSCOPIC ULTRA SOUND GUIDED FNA OF GI TRACT AND PANCREAS Prof. Fernando Schmitt Medical Faculty of Porto University, Porto, Portugal IPATIMUP General Secretary of the International Academy of Cytology
More informationDisclosures. Outline. What IS tumor budding?? Tumor Budding in Colorectal Carcinoma: What, Why, and How. I have nothing to disclose
Tumor Budding in Colorectal Carcinoma: What, Why, and How Disclosures I have nothing to disclose Soo-Jin Cho, MD, PhD Assistant Professor UCSF Dept of Pathology Current Issues in Anatomic Pathology 2017
More informationDIAGNOSTIC DILEMMA. Case Reports Clinical history. Materials and Methods
DIAGNOSTIC DILEMMA A Metastatic Renal Carcinoid Tumor Presenting as Breast Mass: A Diagnostic Dilemma Farnaz Hasteh, M.D., 1 Robert Pu, M.D., Ph.D., 2 and Claire W. Michael, M.D. 2 * We present clinicopathological
More informationUpdate on staging colorectal carcinoma, the 8 th edition AJCC. General overview of staging. When is staging required? 11/1/2017
Update on staging colorectal carcinoma, the 8 th edition AJCC Dale C. Snover, MD November 3, 2017 General overview of staging Reason for uniform staging Requirements to use AJCC manual and/or CAP protocols
More information57th Annual HSCP Spring Symposium 4/16/2016
An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no
More informationEUS FNA NEUROENDOCRINE TUMORS. A. Ginès Endocopy Unit Hospital Cínic. Barcelona (Spain)
EUS FNA NEUROENDOCRINE TUMORS A. Ginès Endocopy Unit Hospital Cínic. Barcelona (Spain) GI NEUROENDOCRINE TUMORS GENERAL CONCEPTS Rare neoplasms arising from the neuroendocrine cells of the GI tract Include:
More informationNeuro-endocrine and pancreatic non-adenocarcinomas. Marc Engelbrecht, AMC, Amsterdam
Neuro-endocrine and pancreatic non-adenocarcinomas Marc Engelbrecht, AMC, Amsterdam Pancreatic Tumors q Epithelial Exocrine q Mesenchymal Ductal Adenocarcinoma (85-95%) Metastasis Lymfoma Acinar Cell Carcinoma
More informationEvaluation of AGA and Fukuoka Guidelines for EUS and surgical resection of incidental pancreatic cysts
Evaluation of AGA and Fukuoka Guidelines for EUS and surgical resection of incidental pancreatic cysts Authors Alexander Lee 1, Vivek Kadiyala 2,LindaS.Lee 3 Institutions 1 Texas Digestive Disease Consultants,
More informationHow to Recognize Gynecologic Cancer Cells from Pelvic Washing and Ascetic Specimens
How to Recognize Gynecologic Cancer Cells from Pelvic Washing and Ascetic Specimens Wenxin Zheng, M.D. Professor of Pathology and Gynecology University of Arizona zhengw@email.arizona.edu http://www.zheng.gynpath.medicine.arizona.edu/index.html
More informationTHYROID CYTOLOGY THYROID CYTOLOGY FINE-NEEDLE-ASPIRATION ANCILLARY TESTS IN THYROID FNA
ANCILLARY TESTS IN THYROID FNA Prof. Fernando Schmitt Department of Pathology and Oncology, Medical Faculty of Porto University Head of Molecular Pathology Unit, IPATIMUP General-Secretary of the International
More informationIntraductal Papillary Mucinous Neoplasms: We Still Have a Way to Go! Francesco M. Serafini, MD, FACS
Intraductal Papillary Mucinous Neoplasms: We Still Have a Way to Go! Francesco M. Serafini, MD, FACS Brooklyn VAMC September 21 st GI Grand Rounds - What is it? - Clinical entity that has emerged from
More informationCONSIDERATIONS IN DEVELOPMENT OF PEMBROLIZUMAB IN MSI-H CANCERS
CONSIDERATIONS IN DEVELOPMENT OF PEMBROLIZUMAB IN MSI-H CANCERS December 2017 Christine K. Gause, Ph.D Executive Director, Biostatistics. 2 Microsatellite Instability-High Cancer - USPI KEYTRUDA is indicated
More informationRadiology Pathology Conference
Radiology Pathology Conference Sharlin Johnykutty,, MD, Cytopathology Fellow Sara Majewski, MD, Radiology Resident Friday, August 28, 2009 Presentation material is for education purposes only. All rights
More informationCase Report Tumor-to-Tumor Metastasis: Lung Carcinoma Metastasizing to Thyroid Neoplasms
Case Reports in Pathology Volume 2015, Article ID 153932, 5 pages http://dx.doi.org/10.1155/2015/153932 Case Report Tumor-to-Tumor Metastasis: Lung Carcinoma Metastasizing to Thyroid Neoplasms Shiuan-Li
More informationCytopathology Study Day 16 April RCPath - BAC. Digital cytology: EUS FNA pancreas and head and neck
Cytopathology Study Day 16 April 2017 Guy s Hospital London RCPath - BAC Digital cytology: EUS FNA pancreas and head and neck R. Dina MD, FIAC, FRCPath Consultant Cyto/Histopathologist Hon Sen Lecturer
More informationMedullary carcinoma of the pancreas radiologically followed up as a cystic lesion for 9 years: a case report and review of the literature
Yago et al. Surgical Case Reports (2018) 4:80 https://doi.org/10.1186/s40792-018-0487-3 CASE REPORT Open Access Medullary carcinoma of the pancreas radiologically followed up as a cystic lesion for 9 years:
More informationRecent advances in breast cancers
Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response
More informationColon and Rectum: 2018 Solid Tumor Rules
2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING Colon and Rectum: 2018 Solid Tumor Rules 1 Colon and Rectum Solid Tumor Rules Separate sections for: Introduction Changes from 2007 MP/H rules Equivalent
More informationCOLON AND RECTUM SOLID TUMOR RULES ABSTRACTORS TRAINING
COLON AND RECTUM SOLID TUMOR RULES ABSTRACTORS TRAINING COLON AND RECTUM SOLID TUMOR RULES Separate sections for: Introduction Changes from 2007 MP/H rules Equivalent Terms Terms that are NOT Equivalent
More information