Dr Marie Bruyneel and Deborah Konopnicki. BVIKM/SBMIC November 8th, 2012
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1 Dr Marie Bruyneel and Deborah Konopnicki BVIKM/SBMIC November 8th, 2012
2 Men, 54 years Emergency room on end october 2009 Sent by his family doctor for Influenza A H1N1? Viral syndrom, cough, fever 39 (7j) No improvment with oral antibiotics Hallucination for 2 days Lost 8 kg since 1 month From Poland, in Belgium since 2009 Building worker, 5 beers/day, smoker ( 34 PY).
3 Physical examination: Restless, difficult to examine 38 C SAO2 91% Blood test: Whites cells 10700, 83% PN CRP: 218 mg/dl K+:2.6mEq/L plateletts: Moderate liver tests abnormalities 2 Blood cultures
4 1. Pneumonia 2. Alcohol withdrawal syndrom Start Amoxicilline + Clavulanate 1g qd
5 Evolution Unfavorable Fever 39,5 ; hypoxemia PaO2=55 mm Hg CRP: 360 mg/dl after 4 days of ABtherapy Repeated blood cultures remain negative Nasopharyngal swabs: Rapid Ag detection for Influenza, RSV, adénovirus Viral culture repeatdly Urine culture - Sputum (saliva): levures (candida albicans) shift Piperacillin+Tazobactam 4X4 g/j Mouth candidosis R/fluconazole Type II diabetes (HbA1c 6.2%) R/ glucophage
6 What diagnostic prodecure would you rank first? 1 - Skin test for tuberculosis Serum Aspergillus antigen (galactomannan test) 3 - Chest CT and bronchoalveolar lavage 4 - Transbronchic biospsies 5 - Honestly, I have no idea
7 What diagnostic prodecure would you rank first? 1 - Skin test for tuberculosis 4% 2 - Serum Aspergillus antigen (galactomannan test) 3 - Chest CT and bronchoalveolar lavage 4 - Transbronchic biospsies 6% 2% 83% 5 - Honestly, I have no idea 5%
8 Thorax CT Mediastinal adenopathies. Pneumonia of the left inferior pulmonary lobe and pleural reaction. Numerous nodulary infiltrates with blurred limits in the 2 lungs, in particular in the periphery zone. Nodular lesions some with excavation. X
9 Among the diagnoses proposed by the radiologist, which one is your choice? 1 - Mycobacterial infection Invasive aspergillosis 3 - Actinomycosis 4 - Coccidioidomycosis
10 Among the diagnoses proposed by the radiologist, which one is your choice? 1 - Mycobacterial infection 49% 2 - Invasive aspergillosis 43% 3 - Actinomycosis 6% 4 - Coccidioidomycosis 2%
11 Investigations (1) Legionella urinary antigen detection negative twice Serologies are negative for Mycoplasma, Q fever HIV, Hepatitis A, B and C, CMV. Chlamydophila are elevated IgG and IgA anti LPs but controls remain stable so not in favour of acute infection Fan and ANCA are negative. RF =65 (<14 UI/ml) Nasopharyngal swabs: PCR for influenza A- and H1N1 Viral culture negative
12 Investigations (2) Sputum cultures: BK: direct exam negative (4X) rares colonies de Candida albicans (5X) Aspergillus fumigatus (Nov 6 : 4 colonies; Nov 12: 1 colony) Serum cryptococcal Ag and Galctomannan (2x) : negative Broncho-alveolar lavage (2X): BK DE and PCR are negative Mould cultures are negative Galactomannan ag detection= 0,12. Transbronchic Biopsies nov 9 th and dec 1 st : unspecific lymphocytic infiltrate, bronchiolitis Stop Piperacillin+Tazobactam after 7 days : CRP 66 mg/dl Start treatment against tuberculosis mid nov
13 What is the PPV of BAL Galactomannan in non-neutropenic patients with Aspergillosis? <25% % % 4 - >75%
14 What is the PPV of BAL Galactomannan in non-neutropenic patients with Aspergillosis? 1 - <25% 17% % 28% % 27% 4 - >75% 28%
15 What is the PPV of BAL Galactomannan in non-neutropenic neutropenic patients with Aspergillosis? 73 patients: 6 aspergillosis BAL GL 0.5 GL 1 Sensitivity 100% 100% Specificity 77% 88% NPV 100% 100% PPV 29% 43%
16 Evolution: end of November Low grade fever: C Mild leucocytosis: 12,000 /µl (75% of PMN) Mild inflammatory syndrom: mg/dl Repeated chest CT: worsened PET Scan: Lung bilateral captation unspecific C est PIRE!!!
17 Evolution: end of November Stop antituberculous therapy after 3 weeks Vibramycin (serologic results for Chlamydophila) Slow reaction: Brain CT : maxillary sinusitis Lumbar puncture: protein are slightly increased C est PIRE!!!? Cirrhosis (albumine 2.6, INR 1.5) but liver CT normal Hyper globulinemia M + IgG Kappa monoclonality Free and (urine) 2 microglobuline Bone marrow aspirate is normal
18 Thoracoscopy + pulmonary biopsies on december 7th:
19 Multiple lung foci of infection with pus. No lymphoma. No tuberculosis. Special colotration (PAS, Zielh and Grocott) show aspergillus within granulation tissu. Start MERONEM 2g X3 for nosocomial lung infection (fever and inflammation) after surgery Start Amphotericine B 50 mg IV x1 for 3 weeks Shift in Voriconazole 350 mg x2/day/ 9 weeks
20 Are case-report papers on invasive aspergilloses in immunocompetent patients rare? < C est PIRE!!! 4 - >50
21 Are case-report papers on invasive aspergilloses in immunocompetent patients rare? 1 - <10 12% C est PIRE!!! 28% 36% 4 - >50 24%
22 Are case-report papers on invasive aspergilloses in immunocompetent patients rare?
23 EVOLUTION Clinically: rapidly better (no fever, +4kg) Lab: GB 11300, PN 70%, CRP= 40 CT: 28/1 25/2
24 Conclusion 1. Invasive pulmonary aspergillosis (favoured by viral infection?) 2. Maxillary sinusitis 3. Several mild immune defects Mild diabetes II Alcoholic liver dysfunction Monoclonal gammopathy 4. Bacterial lung infections
25 Could there be a link between Influenza infection and Invasive Aspergillosis? 1. Yes but only in immunocompromised patients 2. Yes but only in immunocompetent patients 3. Yes in both immuno- compromised and competent patients 4. No
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