Triple-Negative Breast Cancer Time to Slice and Dice? Carsten Denkert, MD Charité University Hospital Berlin, Germany

Size: px
Start display at page:

Download "Triple-Negative Breast Cancer Time to Slice and Dice? Carsten Denkert, MD Charité University Hospital Berlin, Germany"

Transcription

1 Triple-Negative Breast Cancer Time to Slice and Dice? Carsten Denkert, MD Charité University Hospital Berlin, Germany

2 Triple-Negative Breast Cancer (TNBC) 2018 Presentation Outline The molecular heterogeneity and clinical diversity of TNBC Pathologic and molecular characteristics of both hereditary and nonhereditary subtypes of the disease Different approaches for subtyping Potential prognostic biomarkers and therapeutic targets in TNBC PD-L1 and other immunologic biomarkers Androgen-receptor signaling The relevance of deficiencies in DNA repair Current technologies for evaluating defects in DNA repair

3 The Simple View Three Subtypes of Breast Cancer Triple-negative (15%) HR-positive (70%) HER2-positive (15%) Chemotherapy Endocrine therapy Anti-HER2 therapy HER2, human epidermal growth factor receptor 2; HR, hormone receptor

4 The Simple View Extended Subtypes of TNBC (?) Triple-negative (15%) Stem-like AR-pos Mesenchymal Immune Basallike 2 Basallike 1 Challenges to define TNBC subtypes: Different subgroups Mixture of tumor-cell features and tumor-microenvironment Subtypes are overlapping No established diagnostic assay AR, androgen receptor positive; pos, positive

5 Molecular Model for TNBC Biologic Features of a Heterogeneous Disease HRD, homologous recombination deficiency; METABRIC, Molecular Taxonomy of Breast Cancer International Consortium; TIL, tumor-infiltrating lymphocytes; TCGA, The Cancer Genome Atlas Denkert C, et al. Lancet. 2017;389(10087):

6 TNBC Pathologic Characteristics The classical histology High-grade IDC Triple-Negative High nuclear grade Mitoses Solid growth Event-Free Survival, % pcr no pcr High proliferation Time Since Randomization, Years 33% pcr rate IDC, invasive ductal carcinoma; pcr, pathologic complete response Cortazar P, et al. Lancet. 2014;384(9938):

7 TNBC Special Situations The classical histology High-grade IDC Salivary gland like tumors better prognosis, not real TNBC High nuclear grade Mitoses Solid growth Medullary BC immune activation Observed in other TNBCs as well No clearly defined entity High proliferation Minimal ER expression (1% to 9%) Borderline between luminal and TN tumors BC, breast cancer; TN, triple-negative Rakha EA, et al. J Clin Oncol. 2008;26(15):

8 Different Approaches to Molecular Subtyping of TNBC Lehmann BD, et al. J Clin Invest. 2011;121(7): Analysis restricted to the TNBC group. Sørlie T, et al. Proc Natl Acad Sci U S A. 2001;98(19): Comparison of all breast cancer subtypes. Burstein et al. Clin Cancer Res. 2015;21(7): Analysis restricted to the TNBC group. 6 groups: Basal-like 1 Basal-like 2 Immunomodulatory Mesenchymal-like Mesenchymal stem-like Luminal/AR 2 groups: basal-like claudin-low 4 groups: Basal-like immuno suppressed Basal-like immune activated Mesenchymal Luminal/AR Overlapping signatures in different approaches Currently no standardized diagnostic test for molecular subtyping Reduction of 2188-gene algorithm (Lehmann) to a 101-gene algorithm was successful (Ring BZ, et al. BMC Cancer. 2016;16:143.) Consistent molecular motives: Luminal/AR Immune-activated Two types of basallike tumors Mesenchymal Basis for molecular targeted therapy of TNBC

9 TNBC Subtypes Have Different Therapy Response Rates Lehmann groups groups: Basal-like 1; Basal-like 2 Immunomodulatory; Mesenchymal-like Mesenchymal-stem-like; Luminal/AR UNS BL1 BL2 IM M MSL LAR P<.04 pcr, % P<.01 pcr, % P<.011 pcr, % Lehmann BD, et al. PLoS One. 2016;11(6):e Highest response rate: Lowest response rate: BL1 BL2; Luminal/AR

10 Immune Activation Is Observed in Many TNBC Subtypes Lehmann groups groups: Basal-like 1; Basal-like 2 Immunomodulatory; Mesenchymal-like Mesenchymal-stem-like; Luminal/AR UNS BL1 BL2 IM M MSL LAR Lehmann BD, et al. PLoS One. 2016;11(6):e Lehmann BD, et al. J Clin Invest. 2011;121(7):

11 Immune Activation Is Observed in Many TNBC Subtypes Lehmann groups groups: Basal-like 1; Basal-like 2 Immunomodulatory; Mesenchymal-like Mesenchymal-stem-like; Luminal/AR UNS BL1 BL2 IM M MSL LAR Lehmann groups groups: Basal-like 1; Basal-like 2 Mesenchymal-like; Luminal/AR BL1 BL2 M LAR excluded 2016 IM = presence of immune cells MSL = presence stromal cells Immune activation TILs Lehmann BD, et al. PLoS One. 2016;11(6):e Lehmann BD, et al. J Clin Invest. 2011;121(7): immune genes

12 Immune Gene Signature: Correlation With TIL Morphology and Chemotherapy Response in GeparSixto cold hot intermediate PDL1 IDO1 PD1 CTLA4 pcr Rate, % CXCL9 10 CD8A CCL5 CXCL Immune-A Immune-B Immune-C Immune-type A C B Denkert C, et al. J Clin Oncol. 2015;33(9): IGKC CD21 FOXP3 CD80 HR+ HRstrLy (%) LPBC n=481 LPBC Cases, % P< Immune-A Immune-B Immune-C

13 TILs and Increased Chemotherapy Response Rates in Breast Cancer Combined Analysis of 6 Neoadjuvant Trials (N = 3771) 62.5 P<.0005 P<.0005 P<.0005 P<.0005 pcr Rate, % Low (0% to 10%) Intermediate (11% to 59%) High ( 60%) n= All Patients Lum/HER2- HER2+ TNBC pcr: ypt0ypn0 Denkert C, et al. Lancet Oncol. 2018;19(1):40-50.

14 Univariate analysis Multivariate analysis all baseline parameters Multivariate analysis all baseline parameters and pcr Prognosis: High TILs Improved Survival in HER2+ and TNBC high TILs = better survival Disease-Free Survival low TILs = better survival HR per 10% P value All tumors 1.02 ns TNBC HER Lum/HER ns All tumors TNBC HER Lum/HER ns All tumors TNBC 0.95 ns HER Lum/HER ns high TILs = better surival Overall Survival low TILs = better survival HR per 10% P value All tumors 1.01 ns TNBC HER ns Lum/HER All tumors 0.96 ns TNBC HER Lum/HER All tumors 0.99 ns TNBC 0.95 ns HER ns Lum/HER Denkert C, et al. Lancet Oncol. 2018;19(1): ns, not significant

15 TNBC Strata: -TILs (low/med/ high) N = 174 R GeparNuevo Study Design Window of opportunity Durvalumab Placebo 2 weeks Window phase stopped after patient 117 (request of IDMC) Core biopsy nab-pac +Durvalumab nab-pac +Placebo 12 weeks Clinical response ECx4 +Durvalumab ECx4 +Placebo 8 weeks Samples* Samples** Samples** Samples** Surgery Primary endpoint: - pcr ypt0 ypn0 Secondary biomarker endpoints: - TILs - Ki-67 - Immune mrna marker - PD-L1 *Tissue: FFPE, fresh frozen; Liquid biopsies: full blood; plasma, serum **Tissue: FFPE, fresh frozen; Liquid biopsies: plasma, serum

16 GeparNuevo: Complete Cohort and Window Cohort - pcr ypt0, ypn0 80% 70% 60% 50% 40% Complete cohort n=174 (primary endpoint) Window subcohort (exploratory) n= % P =.287* Adjusted** OR 1.53 [95%CI ] P = % 80% 70% 60% 50% 40% 61.0% P = % 30% 20% 10% 0% Durvalumab Placebo N = 88 N = 86 Loibl S, et al. J Clin Oncol. 2018;36(suppl): Abstract % 20% 10% 0% Durvalumab Placebo N = 59 N = 58 * Continuous corrected χ² test ** For stratification factor (TIL groups)

17 GeparNuevo: Subgroup Analysis GeparNuevo preliminary conclusion: Timing of immunotherapy might be important Ongoing translational research Validation in additional trials Loibl S, et al. J Clin Oncol. 2018;36(suppl): Abstract 104.

18 Genomics of TNBC: Number of Mutations in Breast Cancer Mutational Burden (Whole-Exome NGS Sequencing) P = 1.4e-14 P = 1.4e number of mutated genes number of mutated genes G1 G2 G3 HR+ HER2+ HER2+ TNBC HER2- HR+ HR- Budczies J, et al. J Pathol Clin Res. 2015;1(4):

19 Mutational Burden, Therapy Response, and Prognosis MDACC cohort, n = 29 TCGA cohort, n = 101 P =.05 P =.029 Jiang T, et al. PLoS Med, 2016;13(12): e

20 BRCA Mutations in TNBC The majority of hereditary breast cancers show a TN-phenotype (75% to 80%) But still, most TNBC are nonhereditary BCs BRCA mutations are relevant for response to PARP-inhibitors and/or platin-therapy BRCAness : there are tumors that show a homologous recombination deficiency (HRD) without a BRCA mutation these might also respond to PARP-inhibitors/platin-therapy

21 HRD - Biomarker Strategies and Tumor Heterogeneity Different Assays Identify Overlapping Populations Methods for HR deficiency: NGS sequencing for BRCA In normal cells (germline) In tumor cells HDR score Genomic scars Different methods Different cutpoints HRDetect HRD based on WES GeparSixto: 19.8% gbrca mutant 30.3% tbrca mutant 66.8% HRD score high 70.5% any HR deficiency von Minckwitz G, et al. Cancer Res. 2017; 77(4 Suppl): Abstract P

22 Additional Options HRDetect Somatic mutational signatures (=mutation patterns) Physiologic readout of the DNA damage and DNA repair processes that have occurred through tumorigenesis Measured by whole-genome sequencing 98.7% sensitivity for BRCA1/2-mutated tumors Davies H, et al. Nat Med. 2017;23(4):

23 HRD and BRCA As Biomarkers in Clinical Trials GeparSixto Trial (neoadjuvant, early BC): Increased overall CTX response with gbrca1 mutations No carboplatin difference with gbrca1 mutations Positive carbo effect in BRCA wildtype (Increased pcr with HRD, no additional carbo effect) TNT Trial (advanced/metastatic BC): Increased carboplatin response with gbrca1 mutations (No difference with HRD assay) Vn Minckwitz G et al ASCO 2104 Von Minckwitz G, et al. J Clin Oncol. 2014;32(5s):Abstract Updated by Hahnen E, in press Tutt A, et al. Nat Med. 2018;24(5):

24 Mina A, et al. Onco Targets Ther. 2017;10: Parker JS, et al. J Clin Oncol. 2015;33(15 suppl): Vera-Badillo FE, et al. J Natl Cancer Inst. 2014;106(1):djt319. Additional Biomarkers: Androgen Receptors in TNBC AR is present in 13% to 37% of TNBC Detectable by immunohistochemistry Gene expression analysis under development Target for anti-androgenic therapy AR positive TNBC: Better prognosis (Consider AR testing in low-proliferative TNBC)

25 Additional Biomarkers PD-L1 Expression in Breast Cancer Study n %PD-L1 Positive Wang ZQ, et al. Oncotarget. 2017;8(31): Muenst S, et al. Breast Cancer Res Treat. 2014;146(1): Bertucci F, et al. Oncotarget. 2015;6(15): Ali HR, et al. Ann Oncol. 2015;26(7): % all tumors 35.4% in TNBC % all tumors % of inflammatory BCs 3916 PD-L1 immune cells 6% PD-L1 tumor cells 1.7% Membranous staining; associated with better RFS in TNBC Membranous or cytoplasmic staining; associated with worst survival in all subtypes Staining compared to normal breast tissue; Correlation with increased pcr rate Evaluation on TMAs Open questions: Best cutpoints Tumor cells vs TILs Role in immunotherapy trials Currently not a biomarker for clinical practice

26 Take-Home Message TNBC TNBC is a clinical term, not a defined disease entity Molecular features of TNBC include: High immune infiltrate AR expression BRCA mutations / BRCAness Mesenchymal and stem-like features Basal-like phenotype Increased mutational load Each molecular alteration is found only in a subset of TNBC; there is overlap between subtypes They cannot be used for stable subtyping of TNBC, but they are the basis for new therapeutic options Denkert C, et al. Lancet. 2017;389(10087):

27

10/15/2012. Biologic Subtypes of TNBC. Topics. Topics. Histopathology Molecular pathology Clinical relevance

10/15/2012. Biologic Subtypes of TNBC. Topics. Topics. Histopathology Molecular pathology Clinical relevance Biologic Subtypes of TNBC Andrea L. Richardson M.D. Ph.D. Brigham and Women s Hospital Dana-Farber Cancer Institute Harvard Medical School Boston, MA Topics Histopathology Molecular pathology Clinical

More information

TNBC: What s new Déjà vu All Over Again? Lucy R. Langer, MD MSHS Compass Oncology - SABCS 2016 Review February 21, 2017

TNBC: What s new Déjà vu All Over Again? Lucy R. Langer, MD MSHS Compass Oncology - SABCS 2016 Review February 21, 2017 TNBC: What s new Déjà vu All Over Again? Lucy R. Langer, MD MSHS Compass Oncology - SABCS 2016 Review February 21, 2017 The problem with TNBC 1. Generally more aggressive 2. ONLY chemotherapy 3. No other

More information

Role of chemotherapy in BRCA and Triple negative breast cancer. Fernando Moreno Servicio de Oncología Médica Hospital Clinico San Carlos

Role of chemotherapy in BRCA and Triple negative breast cancer. Fernando Moreno Servicio de Oncología Médica Hospital Clinico San Carlos Role of chemotherapy in BRCA and Triple negative breast cancer Fernando Moreno Servicio de Oncología Médica Hospital Clinico San Carlos Association between TNBC & germline mutations in BRCA 1/2 TNBC is

More information

What to do after pcr in different subtypes?

What to do after pcr in different subtypes? What to do after pcr in different subtypes? Luca Moscetti Breast Unit Università degli Studi di Modena e Reggio Emilia Policlinico di Modena, Italy Aims of neoadjuvant therapy in breast cancer Primary

More information

Triple-Negative Breast Cancer

Triple-Negative Breast Cancer June 2017 Triple-Negative Breast Cancer Amir Sonnenblick, MD, PhD Sharett institute of oncology Hadassah-Hebrew university medical center, Jerusalem, Israel This presentation is the intellectual property

More information

Carcinoma mammario triple nega0ve Nuove acquisizioni biologiche. Giuseppe Curigliano MD PhD UNIMI & IEO

Carcinoma mammario triple nega0ve Nuove acquisizioni biologiche. Giuseppe Curigliano MD PhD UNIMI & IEO Carcinoma mammario triple nega0ve Nuove acquisizioni biologiche Giuseppe Curigliano MD PhD UNIMI & IEO Outline San Antonio Breast Cancer Symposium, December 5-9, 2017 The year of DNA Repair targe?ng Olaparib

More information

ENFERMEDAD AVANZADA Qué hacemos con el triple negativo? Nuevas aproximaciones

ENFERMEDAD AVANZADA Qué hacemos con el triple negativo? Nuevas aproximaciones ENFERMEDAD AVANZADA Qué hacemos con el triple negativo? Nuevas aproximaciones Javier Cortes, Hospital Universitario Ramon y Cajal, Madrid Vall d Hebron Institute of Oncology (VHIO), Barcelona Triple Negative

More information

Perspectivas de desarrollo de la inmunoterapia en cáncer de mama hereditario. Luis de la Cruz Merino Oncología Médica HUVMacarena (Sevilla)

Perspectivas de desarrollo de la inmunoterapia en cáncer de mama hereditario. Luis de la Cruz Merino Oncología Médica HUVMacarena (Sevilla) Perspectivas de desarrollo de la inmunoterapia en cáncer de mama hereditario Luis de la Cruz Merino Oncología Médica HUVMacarena (Sevilla) Outline Immunology and breast cancer Clinical trials with modern

More information

Dieta Brandsma, Department of Neuro-oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

Dieta Brandsma, Department of Neuro-oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands What is hot in breast cancer brain metastases? Dieta Brandsma, Department of Neuro-oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands 8th Annual Brain Metastases Research and Emerging Therapy

More information

Gene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA

Gene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA Gene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA When Are Biomarkers Ready To Use? Same Rules for Gene Expression Panels Key elements

More information

Triple Negative Breast cancer New treatment options arenowhere?

Triple Negative Breast cancer New treatment options arenowhere? Triple Negative Breast cancer New treatment options arenowhere? Ofer Rotem, M.D., B.Sc. Breast Unit, Davidoff center Rabin Medical center October 2017 Case 6/2013 - M.D., 38 years old woman, healthy, no

More information

Question 1 A. ER-, PR-, HER+ B. ER+, PR+, HER2- C. ER-, PR+, HER2- D. ER-, PR-, HER2- E. ER-, PR+, HER2+

Question 1 A. ER-, PR-, HER+ B. ER+, PR+, HER2- C. ER-, PR+, HER2- D. ER-, PR-, HER2- E. ER-, PR+, HER2+ Triple Negative Breast Cancer Laura C. Collins, M.D. Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Question 1 The tumor depicted on the next slide

More information

Alternativas terapéuticas en fenotipo triple negativo Javier Cortes, Hospital Universitario Ramon y Cajal, Madrid

Alternativas terapéuticas en fenotipo triple negativo Javier Cortes, Hospital Universitario Ramon y Cajal, Madrid Alternativas terapéuticas en fenotipo triple negativo Javier Cortes, Hospital Universitario Ramon y Cajal, Madrid Vall d Hebron Institute of Oncology (VHIO), Barcelona Triple Negative Breast Cancer Immunohistochemistry

More information

Triple Negative Breast Cancer

Triple Negative Breast Cancer Triple Negative Breast Cancer Prof. Dr. Pornchai O-charoenrat Division of Head-Neck & Breast Surgery Department of Surgery Faculty of Medicine Siriraj Hospital Breast Cancer Classification Traditional

More information

Subtype-directed therapy of TNBC Global Breast Cancer Conference 2015 & 4th International Breast Cancer Symposium Jeju Island, Korea, April 2015

Subtype-directed therapy of TNBC Global Breast Cancer Conference 2015 & 4th International Breast Cancer Symposium Jeju Island, Korea, April 2015 Subtype-directed therapy of TNBC Global Breast Cancer Conference 2015 & 4th International Breast Cancer Symposium Jeju Island, Korea, April 2015 Ruth M. O Regan, MD Visiting Professor and Division Chief

More information

Contemporary Classification of Breast Cancer

Contemporary Classification of Breast Cancer Contemporary Classification of Breast Cancer Laura C. Collins, M.D. Vice Chair of Anatomic Pathology Professor of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Outline

More information

Medicina de precisión en cáncer de ovario: Determinación de BRCA germinal y somático

Medicina de precisión en cáncer de ovario: Determinación de BRCA germinal y somático Medicina de precisión en cáncer de ovario: Determinación de BRCA germinal y somático Dra. Cristina Martin Lorente Hospital de la Santa Creu i Sant Pau. Barcelona Introduction Ovarian cancer is the fifth

More information

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin

UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University

More information

Breast cancer classification: beyond the intrinsic molecular subtypes

Breast cancer classification: beyond the intrinsic molecular subtypes Breast cancer classification: beyond the intrinsic molecular subtypes Britta Weigelt, PhD Signal Transduction Laboratory CRUK London Research Institute Summary Breast cancer heterogeneity Molecular classification

More information

Terapia sistemica neoadiuvante: in quali tumori? Quali risultati? Dott. Giacomo Pelizzari

Terapia sistemica neoadiuvante: in quali tumori? Quali risultati? Dott. Giacomo Pelizzari Terapia sistemica neoadiuvante: in quali tumori? Quali risultati? Dott. Giacomo Pelizzari Neoadjuvant Treatment A window of opportunity Rational: Historically proposed to enable breast-conserving surgery

More information

SYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER

SYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER SYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Sunil Shrestha 1*, Ji Yuan Yang, Li Shuang and Deepika Dhakal Clinical School of Medicine, Yangtze University, Jingzhou, Hubei Province, PR. China Department

More information

Molecular alterations in triple-negative breast cancer the road to new treatment strategies

Molecular alterations in triple-negative breast cancer the road to new treatment strategies 1 Molecular alterations in triple-negative breast cancer the road to new treatment strategies Carsten Denkert 1, Cornelia Liedtke 2, Andrew Tutt 3, Gunter von Minckwitz 4 Affiliations of authors: 1 Institute

More information

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting International Society of Breast Pathology USCAP 2017 Annual Meeting Immune Targeting in Breast Cancer Ashley Cimino-Mathews, MD Assistant Professor of Pathology and Oncology The Johns Hopkins Hospital

More information

GBG/AGO-B study groups

GBG/AGO-B study groups Prediction of pathological complete response (pcr) by Homologous Recombination Deficiency (HRD) after carboplatin-containing neoadjuvant chemotherapy in patients with TNBC Results from GeparSixto. Gunter

More information

SFSPM Novembre Valeur prédictive et pronostique de l infiltrat immunitaire dans les cancers du sein traités par chimiothérapie néoadjuvante

SFSPM Novembre Valeur prédictive et pronostique de l infiltrat immunitaire dans les cancers du sein traités par chimiothérapie néoadjuvante SFSPM Novembre 217 Valeur prédictive et pronostique de l infiltrat immunitaire dans les cancers du sein traités par chimiothérapie néoadjuvante Dr Fabien REYAL Service de Chirurgie INSERM U932 Immunity

More information

Clinical Research on PARP Inhibitors and Triple-Negative Breast Cancer (TNBC)

Clinical Research on PARP Inhibitors and Triple-Negative Breast Cancer (TNBC) Clinical Research on PARP Inhibitors and Triple-Negative Breast Cancer (TNBC) Eric P Winer, MD Disclosures for Eric P Winer, MD No real or apparent conflicts of interest to disclose Key Topics: PARP and

More information

The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer

The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer Laura Spring, MD Breast Medical Oncology Massachusetts General Hospital Primary Mentor: Dr. Aditya Bardia

More information

"BRCAness," PARP and the Triple-Negative Phenotype

BRCAness, PARP and the Triple-Negative Phenotype "BRCAness," PARP and the Triple-Negative Phenotype Prof Alan Ashworth, FRS Disclosures for Professor Alan Ashworth, FRS Consulting Agreements GlaxoSmithKline, Pfizer Inc Patent AstraZeneca Pharmaceuticals

More information

Triple Negative Breast Cancer: Part 2 A Medical Update

Triple Negative Breast Cancer: Part 2 A Medical Update Triple Negative Breast Cancer: Part 2 A Medical Update April 29, 2015 Tiffany A. Traina, MD Breast Medicine Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College Overview What is

More information

Breast cancer: Molecular STAGING classification and testing. Korourian A : AP,CP ; MD,PHD(Molecular medicine)

Breast cancer: Molecular STAGING classification and testing. Korourian A : AP,CP ; MD,PHD(Molecular medicine) Breast cancer: Molecular STAGING classification and testing Korourian A : AP,CP ; MD,PHD(Molecular medicine) Breast Cancer Theory: Halsted Operative breast cancer is a local-regional disease The positive

More information

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression

Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Claudin-4 Expression in Triple Negative Breast Cancer: Correlation with Androgen Receptors and Ki-67 Expression Mona A. Abd-Elazeem, Marwa A. Abd- Elazeem Pathology department, Faculty of Medicine, Tanta

More information

Present Role of Immunohistochemistry in the. Subtypes. Beppe Viale European Institute of Oncology University of Milan Milan-Italy

Present Role of Immunohistochemistry in the. Subtypes. Beppe Viale European Institute of Oncology University of Milan Milan-Italy Present Role of Immunohistochemistry in the Classification of Molecular Subtypes Beppe Viale European Institute of Oncology University of Milan Milan-Italy We know it is many diseases Breast cancer is

More information

Triple Negative Breast Cancer. Eric P. Winer, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA October, 2008

Triple Negative Breast Cancer. Eric P. Winer, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA October, 2008 Triple Negative Breast Cancer Eric P. Winer, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA October, 2008 Triple Negative Breast Cancer 15% 25% Triple Negative 20% HER2+ ER+ Low Grade

More information

Immunotherapy for Breast Cancer. Aurelio B. Castrellon Medical Oncology Memorial Healthcare System

Immunotherapy for Breast Cancer. Aurelio B. Castrellon Medical Oncology Memorial Healthcare System Immunotherapy for Breast Cancer Aurelio B. Castrellon Medical Oncology Memorial Healthcare System Conflicts Research support : Cascadian therapeutics, Puma biotechnology, Odonate therapeutics, Pfizer,

More information

Histological Type. Morphological and Molecular Typing of breast Cancer. Nottingham Tenovus Primary Breast Cancer Study. Survival (%) Ian Ellis

Histological Type. Morphological and Molecular Typing of breast Cancer. Nottingham Tenovus Primary Breast Cancer Study. Survival (%) Ian Ellis Morphological and Molecular Typing of breast Cancer Ian Ellis Molecular Medical Sciences, University of Nottingham Department of Histopathology, Nottingham University Hospitals NHS Trust Histological Type

More information

Triple negative breast cancer Biology and targeted therapy

Triple negative breast cancer Biology and targeted therapy Triple negative breast cancer Biology and targeted therapy MR SCI MED DR I BOŽOVIĆ -SPASOJEVIĆ INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE I VA N A B O Z O V I C @ O U T L O O K. C O M Current challanges

More information

Gábor CSERNI. 1. Bács-Kiskun County Teaching Hospital, Kecskemét 2. University of Szeged, Szeged

Gábor CSERNI. 1. Bács-Kiskun County Teaching Hospital, Kecskemét 2. University of Szeged, Szeged Lymphocytes infiltrant la tumeur (TIL) sur micro-biopsies et pièces opératoires Quel impact clinique? Quels moyens de mise en évidence? Comment restituer les résultats? TILs - Clinical impact / Evaluation

More information

RNA preparation from extracted paraffin cores:

RNA preparation from extracted paraffin cores: Supplementary methods, Nielsen et al., A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor positive breast cancer.

More information

FISH mcgh Karyotyping ISH RT-PCR. Expression arrays RNA. Tissue microarrays Protein arrays MS. Protein IHC

FISH mcgh Karyotyping ISH RT-PCR. Expression arrays RNA. Tissue microarrays Protein arrays MS. Protein IHC Classification of Breast Cancer in the Molecular Era Susan J. Done University Health Network, Toronto Why classify? Prognosis Prediction of response to therapy Pathogenesis Invasive breast cancer can have

More information

Triple negative breast cancer -neoadjuvant and adjuvant systemic therapy

Triple negative breast cancer -neoadjuvant and adjuvant systemic therapy Triple negative breast cancer -neoadjuvant and adjuvant systemic therapy Sung-Bae Kim, MD, PhD Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul, Korea DISCLOSURE

More information

Genomic tests to personalize therapy of metastatic breast cancers. Fabrice ANDRE Gustave Roussy Villejuif, France

Genomic tests to personalize therapy of metastatic breast cancers. Fabrice ANDRE Gustave Roussy Villejuif, France Genomic tests to personalize therapy of metastatic breast cancers Fabrice ANDRE Gustave Roussy Villejuif, France Future application of genomics: Understand the biology at the individual scale Patients

More information

Pathology of Inflammatory Breast Cancer (IBC) A rare tumor

Pathology of Inflammatory Breast Cancer (IBC) A rare tumor Pathology of Inflammatory Breast Cancer (IBC) A rare tumor Jelle Wesseling 1, John Martens 2, Gabe Sonke 1, Carolien Schröder 3 1: Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam

More information

Overview and future horizons of PARP inhibitors in BRCAassociated. Judith Balmaña

Overview and future horizons of PARP inhibitors in BRCAassociated. Judith Balmaña Overview and future horizons of PARP inhibitors in BRCAassociated breast cancer Judith Balmaña PARP inhibitors: Mechanism of action Clinical development: Monotherapy In combination with chemotherapy Ongoing

More information

I SOTTOGRUPPI FENOTIPICI E I RISULTATI SINORA RAGGIUNTI. Marta Bonotto Department of Oncology, University Hospital of Udine, Italy

I SOTTOGRUPPI FENOTIPICI E I RISULTATI SINORA RAGGIUNTI. Marta Bonotto Department of Oncology, University Hospital of Udine, Italy I SOTTOGRUPPI FENOTIPICI E I RISULTATI SINORA RAGGIUNTI Marta Bonotto Department of Oncology, University Hospital of Udine, Italy Breast Cancer Metastatic Breast Cancer (MBC) Metastatic Breast Cancer (MBC)

More information

Emerging Tissue and Serum Markers

Emerging Tissue and Serum Markers Emerging Tissue and Serum Markers for Immune Checkpoint Inhibitors Kyong Hwa Park MD, PhD Medical Oncology Korea University College of Medicine Contents Immune checkpoint inhibitors in clinical practice

More information

San Antonio Breast Cancer Symposium, December 5-9, San Antonio Breast Cancer Symposium, December 5-9, 2017

San Antonio Breast Cancer Symposium, December 5-9, San Antonio Breast Cancer Symposium, December 5-9, 2017 San Antonio Breast Cancer Symposium, December 5-9, 2017 Survival analysis of the prospectively randomized phase III GeparSepto trial comparing neoadjuvant chemotherapy with weekly nab-paclitaxel with solvent-based

More information

Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer

Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer Prognostic significance of stroma tumorinfiltrating lymphocytes according to molecular subtypes of breast cancer Hee Jung Kwon, Nuri Jang, Min Hui Park, Young Kyung Bae Department of Pathology, Yeungnam

More information

Immunotherapy in breast cancer. Carmen Criscitiello, MD, PhD European Institute of Oncology Milan, Italy

Immunotherapy in breast cancer. Carmen Criscitiello, MD, PhD European Institute of Oncology Milan, Italy Immunotherapy in breast cancer Carmen Criscitiello, MD, PhD European Institute of Oncology Milan, Italy Outline Rational for immune-based therapy in breast cancer Immunogenic chemotherapy Targeting immune

More information

Triple Negative Breast Cancer

Triple Negative Breast Cancer GASCO 2016 San Antonio Breast Cancer Symposium Review Triple Negative Breast Cancer Amelia Zelnak, MD, MSc Atlanta Cancer Care Northside Hospital Cancer Institute Disclosures: consultant for Novartis,

More information

ESMO Preceptorship Breast Cancer. Giuseppe Curigliano MD, PhD Breast Cancer Program Division of Early Drug Development Istituto Europeo di Oncologia

ESMO Preceptorship Breast Cancer. Giuseppe Curigliano MD, PhD Breast Cancer Program Division of Early Drug Development Istituto Europeo di Oncologia ESMO Preceptorship Breast Cancer Giuseppe Curigliano MD, PhD Breast Cancer Program Division of Early Drug Development Istituto Europeo di Oncologia Outline Rational for immune-based therapy in BC How to

More information

Molecular classification of breast cancer implications for pathologists. Sarah E Pinder

Molecular classification of breast cancer implications for pathologists. Sarah E Pinder Molecular classification of breast cancer implications for pathologists Sarah E Pinder Courtesy of CW Elston Histological types Breast Cancer Special Types 17 morphological special types 25-30% of all

More information

Breast Cancer: ASCO Poster Review

Breast Cancer: ASCO Poster Review Breast Cancer: ASCO Poster Review Carmen Criscitiello, MD, PhD Istituto Europeo di Oncologia Milano HER2+ SUBTYPE Research questions in early HER2+ BC De-escalation of toxicity without compromising efficacy

More information

Keynote Lecture 1 Advances in Molecular Biology of Pancreatic Cancer: Understanding Genetic Complexity and Molecular Heterogeneity

Keynote Lecture 1 Advances in Molecular Biology of Pancreatic Cancer: Understanding Genetic Complexity and Molecular Heterogeneity Keynote Lecture 1 Advances in Molecular Biology of Pancreatic Cancer: Understanding Genetic Complexity and Molecular Heterogeneity Volker Ellenrieder, MD, PhD University Hospital Gӧttingen Gӧttingen, Germany

More information

Evaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy

Evaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy Evaluation of Pathologic Response in Breast Cancer Treated with Primary Systemic Therapy Eun Yoon Cho, MD, PhD Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University

More information

Advances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings. Eve Rodler, MD University of California at Davis October 2016

Advances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings. Eve Rodler, MD University of California at Davis October 2016 Advances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings Eve Rodler, MD University of California at Davis October 2016 17th Annual Advances in Oncology September 30-October 1, 2016

More information

Understanding and Optimizing Treatment of Triple Negative Breast Cancer

Understanding and Optimizing Treatment of Triple Negative Breast Cancer Understanding and Optimizing Treatment of Triple Negative Breast Cancer Edith Peterson Mitchell, MD, FACP Clinical Professor of Medicine and Medical Oncology Program Leader, Gastrointestinal Oncology Department

More information

Immunohistochemical classification of breast tumours

Immunohistochemical classification of breast tumours Immunohistochemical classification of breast tumours Workshop in Diagnostic Immunohistochemistry September 19 th - 21 th 2018 Anne-Vibeke Lænkholm Department of Surgical Pathology, Zealand University Hospital,

More information

10/15/2012. Inflammatory Breast Cancer vs. LABC: Different Biology yet Subtypes Exist

10/15/2012. Inflammatory Breast Cancer vs. LABC: Different Biology yet Subtypes Exist Triple-Negative Breast Cancer: Optimizing Treatment for Locally Advanced Breast Cancer Beth Overmoyer MD Director, Inflammatory Breast Cancer Program Dana Farber Cancer Institute Overview Inflammatory

More information

Breast Cancer Statistics

Breast Cancer Statistics 1 in 8 Breast Cancer Statistics Incidence Mortality Prevalence 2 Breast Cancer Incidence Breast Cancer Mortality Breast Cancer Prevalence ~$100,000 Female Breast Anatomy Breasts consist mainly of fatty

More information

PARP Inhibitors: Patients Selection. Dr. Cristina Martin Lorente Hospital de la Santa Creu i Sant Pau Formigal, June 23th 2016

PARP Inhibitors: Patients Selection. Dr. Cristina Martin Lorente Hospital de la Santa Creu i Sant Pau Formigal, June 23th 2016 PARP Inhibitors: Patients Selection Dr. Cristina Martin Lorente Hospital de la Santa Creu i Sant Pau Formigal, June 23th 2016 OVARIAN CANCER (OC): MULTIPLES DISEASES Different types with different behaviour

More information

The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now?

The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now? 1 The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now? Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program

More information

Lo Studio Geparsepto. Alessandra Fabi Oncologia Medica 1

Lo Studio Geparsepto. Alessandra Fabi Oncologia Medica 1 Lo Studio Geparsepto Alessandra Fabi Oncologia Medica 1 nab-paclitaxel Versus Solvent-Based Paclitaxel in Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto GBG 69): A Randomised, Phase III Trial

More information

Predicting outcome in metastatic breast cancer

Predicting outcome in metastatic breast cancer Predicting outcome in metastatic breast cancer Aleix Prat, MD, PhD Medical Oncology Department Translational Genomics and Targeted Therapeutics in Solid Tumors Monday, 15 th January, Manchester, UK Disclosures

More information

ESMO PRECEPTORSHIP IN IMMUNO-ONCOLOGY

ESMO PRECEPTORSHIP IN IMMUNO-ONCOLOGY ESMO PRECEPTORSHIP IN IMMUNO-ONCOLOGY LUGANO, MAY 4-5, 2018 Clinical development in ovarian cancer C. Sessa, CH CONTENT Rationale for immunotherapy in ovarian cancer Clinical data with single agent immune

More information

Enterprise Interest Speaker and consultant for Astrazeneca, MSD, BMS, Roche, Pfizer, Novartis, Sanofi Resarch grants from BMS, Roche, MSD, Novartis

Enterprise Interest Speaker and consultant for Astrazeneca, MSD, BMS, Roche, Pfizer, Novartis, Sanofi Resarch grants from BMS, Roche, MSD, Novartis Enterprise Interest Speaker and consultant for Astrazeneca, MSD, BMS, Roche, Pfizer, Novartis, Sanofi Resarch grants from BMS, Roche, MSD, Novartis Centre Jean Perrin Centre de Lutte contre le Cancer d'auvergne

More information

Biomarkers for HER2-directed Therapies : Past Failures and Future Perspectives

Biomarkers for HER2-directed Therapies : Past Failures and Future Perspectives Biomarkers for HER2-directed Therapies : Past Failures and Future Perspectives Ian Krop Dana-Farber Cancer Institute Harvard Medical School Inchon 2018 Adjuvant Trastuzumab Improves Outcomes in HER2+ Breast

More information

Myriad Genetics mychoice HRD Update 06/30/2016

Myriad Genetics mychoice HRD Update 06/30/2016 Myriad Genetics mychoice HRD Update 06/30/2016 1 Forward Looking Statements Some of the information presented here today may contain projections or other forward-looking statements regarding future events

More information

Basement membrane in lobule.

Basement membrane in lobule. Bahram Memar, MD Basement membrane in lobule. Normal lobule-luteal phase Normal lobule-follicular phase Lactating breast Greater than 95% are adenocarcinomas in situ carcinomas and invasive carcinomas.

More information

33 rd Annual J.P. Morgan Healthcare Conference. January 2015

33 rd Annual J.P. Morgan Healthcare Conference. January 2015 33 rd Annual J.P. Morgan Healthcare Conference January 2015 Forward-looking Statements This presentation contains forward-looking statements, which express the current beliefs and expectations of management.

More information

非臨床試験 臨床の立場から 京都大学医学部附属病院戸井雅和

非臨床試験 臨床の立場から 京都大学医学部附属病院戸井雅和 資料 2 2 非臨床試験 臨床の立場から 京都大学医学部附属病院戸井雅和 1 Preclinical studies Therapeutic Window: Efficacy/Toxicity Disease Specificity Subtype Specificity Combination: Concurrent/Sequential Therapeutic situation: Response/

More information

Recent advances in breast cancers

Recent advances in breast cancers Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response

More information

Optimizing anti-her-2 therapies for ABC Potential role of immunotherapy. Javier Cortes, Ramon y

Optimizing anti-her-2 therapies for ABC Potential role of immunotherapy. Javier Cortes, Ramon y Optimizing anti-her-2 therapies for ABC Potential role of immunotherapy Javier Cortes, Ramon y Cajal University Hospital, Madrid, Spain Vall d Hebron Institute of Oncology (VHIO), Medica Scientia Innovation

More information

Management of Triple Negative Breast Cancer. Giuseppe Curigliano MD, PhD University of Milano and European Institute of Oncology

Management of Triple Negative Breast Cancer. Giuseppe Curigliano MD, PhD University of Milano and European Institute of Oncology Management of Triple Negative Breast Cancer Giuseppe Curigliano MD, PhD University of Milano and European Institute of Oncology Outline Heterogeneity of TNBC Targeting TNBC by subtypes New antibody drug

More information

Ex vivo functional assays for Homologous Recombination deficiency in breast cancer. Dik C. van Gent

Ex vivo functional assays for Homologous Recombination deficiency in breast cancer. Dik C. van Gent Ex vivo functional assays for Homologous Recombination deficiency in breast cancer Dik C. van Gent Breast cancer types treatments ER/PR: anti-hormonal therapy HER2: Herceptin Triple negative (TNBC): no

More information

Updates in Molecular Classification of Breast Cancer. Emmanuel Agosto-Arroyo, MD Assistant Member Department of Anatomic Pathology

Updates in Molecular Classification of Breast Cancer. Emmanuel Agosto-Arroyo, MD Assistant Member Department of Anatomic Pathology Updates in Molecular Classification of Breast Cancer Emmanuel Agosto-Arroyo, MD Assistant Member Department of Anatomic Pathology 3/3/2018 Disclosure There are no conflicts of interest. Objectives Describe

More information

La malattia triplo negativa metastatica: quali trattamenti nella pratica clinica?

La malattia triplo negativa metastatica: quali trattamenti nella pratica clinica? 2018 CARCINOMA MAMMARIO: I TRAGUARDI RAGGIUNTI E LE NUOVE SFIDE La malattia triplo negativa metastatica: quali trattamenti nella pratica clinica? Roma, 27 Ottobre 2018 Relatore: Francesca Poggio Disclosure

More information

ESMO Preceptoship in Immuno-Oncology. Clinical Development: Breast Cancer

ESMO Preceptoship in Immuno-Oncology. Clinical Development: Breast Cancer ESMO Preceptoship in Immuno-Oncology Clinical Development: Breast Cancer Prof Giuseppe Curigliano, MD PhD University of Milano and Istituto Europeo di Oncologia Milano, Lombardia, Italy Outline Rational

More information

2015 EUROPEAN CANCER CONGRESS

2015 EUROPEAN CANCER CONGRESS 2015 EUROPEAN CANCER CONGRESS 25-29 September 2015 Vienna, Austria SUMMARY The European Cancer Congress (ECC 2015) combined the 40th European Society for Medical Oncology (ESMO) congress with the 18th

More information

Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants

Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants www.nature.com/npjbcancer REVIEW ARTICLE OPEN Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants Fresia Pareja 1, Felipe C Geyer

More information

XII Michelangelo Foundation Seminar

XII Michelangelo Foundation Seminar XII Michelangelo Foundation Seminar The opportunity of the neoadjuvant approach L. Gianni, Milan, I XII Michelangelo Foundation Seminar Milano, October 12, 2012 The opportunity of the neoadjuvant approach

More information

Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE

Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE Controversies in Breast Pathology ELENA PROVENZANO ADDENBROOKES HOSPITAL, CAMBRIDGE Neoadjuvant Chemotherapy Indications: Management of locally advanced invasive breast cancers including inflammatory breast

More information

Neoadjuvant chemotherapy (NACT) in young women with breast cancer. Hanne Melgaard Nielsen, MD Ph.D Department of Oncology, Aarhus University Hospital

Neoadjuvant chemotherapy (NACT) in young women with breast cancer. Hanne Melgaard Nielsen, MD Ph.D Department of Oncology, Aarhus University Hospital Neoadjuvant chemotherapy (NACT) in young women with breast cancer Hanne Melgaard Nielsen, MD Ph.D Department of Oncology, Aarhus University Hospital Young women according to EUSOMA guidelines Is under

More information

Locally Advanced Breast Cancer: Systemic and Local Therapy

Locally Advanced Breast Cancer: Systemic and Local Therapy Locally Advanced Breast Cancer: Systemic and Local Therapy Joseph A. Sparano, MD Professor of Medicine & Women s Health Albert Einstein College of Medicine Associate Chairman, Department of Oncology Montefiore

More information

Table S2. Expression of PRMT7 in clinical breast carcinoma samples

Table S2. Expression of PRMT7 in clinical breast carcinoma samples Table S2. Expression of PRMT7 in clinical breast carcinoma samples (All data were obtained from cancer microarray database Oncomine.) Analysis type* Analysis Class(number sampels) 1 2 3 4 Correlation (up/down)#

More information

THE SEARCH FOR BIOMARKERS IN BLADDER CANCER

THE SEARCH FOR BIOMARKERS IN BLADDER CANCER THE SEARCH FOR BIOMARKERS IN BLADDER CANCER CDDP and IO WORLD ALEJO RODRÍGUEZ-VIDA MD PhD Consultant Medical Oncologist Associate Professor Hospital del Mar, Barcelona November 23 rd 2018 DISCLOSURE OF

More information

How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer

How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer Global Breast Cancer Conference 2016 & 5 th International Breast Cancer Symposium April 29 th 2016, 09:40-10:50 How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer

More information

Clinical pathological and epidemiological study of triple negative breast cancer

Clinical pathological and epidemiological study of triple negative breast cancer International Journal of Research in Medical Sciences Ajay A et al. Int J Res Med Sci. 217 Jun;5(6):2657-2661 www.msjonline.org pissn 232-71 eissn 232-12 Original Research Article DOI: http://dx.doi.org/1.1823/232-12.ijrms2172465

More information

Neoadjuvant chemotherapy as a research model

Neoadjuvant chemotherapy as a research model Neoadjuvant chemotherapy as a research model Prof. Dr. Sibylle Loibl Co-Chair of the German Breast Group Sana Klinikum Offenbach Heilung durch Innovation, Kompetenz und Partnerschaft DFS and OS after neoadjuvant

More information

Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience

Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience Curzon M, Curzon C, Heidel RE, Desai P, McLoughlin J, Panella T, Bell

More information

6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017

6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017 Primary Care Focus Symposium July 1, 2017 Grace Wang MD I do not have any relevant financial relationships to disclose at this time TARGETING THE TARGETS IN 2017 What are

More information

AGO e. V. in der DGGG e.v. sowie in der DKG e.v.

AGO e. V. in der DGGG e.v. sowie in der DKG e.v. AGO e. V. in der DGGG e.v. sowie in der DKG e.v. Guidelines Breast Version 2015.1 www.ago-online.de Disease-Free and Overall Survival in Metastatic Breast Cancer AGO e. V. in der DGGG e.v. sowie in der

More information

Recent Update in Management of Breast Cancer: Medical Oncology. Jin Hee Ahn, M.D., PhD. 23-April-2015

Recent Update in Management of Breast Cancer: Medical Oncology. Jin Hee Ahn, M.D., PhD. 23-April-2015 2015 GBCC & 4 th IBCS 1/37 Recent Update in Management of Breast Cancer: Medical Oncology Jin Hee Ahn, M.D., PhD. 23-April-2015 Department of Oncology, Asan Medical Center, UUCM, Seoul, Korea 2/37 3/37

More information

NeoadjuvantTreatment In BC When, How, Who?

NeoadjuvantTreatment In BC When, How, Who? NeoadjuvantTreatment In BC When, How, Who? Clifford Hudis, M.D. Chief, Breast Cancer Medicine Service, MSKCC Professor of Medicine, Weill Cornell Medical College President, ASCO 15 Potential Benefits Of

More information

Was gynäkologische OnkologInnen über Erblichkeit wissen sollten. 9. Brustkrebskongress Köln und Niederrhein 2016

Was gynäkologische OnkologInnen über Erblichkeit wissen sollten. 9. Brustkrebskongress Köln und Niederrhein 2016 Was gynäkologische OnkologInnen über Erblichkeit wissen sollten Rita K. Schmutzler, Universitätsklinik Köln Koordinatorin des Konsortiums Familiärer Brust- und Eierstockkrebs 9. Brustkrebskongress Köln

More information

Virtual Journal Club. Ovarian Cancer. Reference Slides. Platinum-Sensitive Recurrent Ovarian Cancer: Making the Most of Emerging Targeted Therapies

Virtual Journal Club. Ovarian Cancer. Reference Slides. Platinum-Sensitive Recurrent Ovarian Cancer: Making the Most of Emerging Targeted Therapies Virtual Journal Club Ovarian Cancer Reference Slides Platinum-Sensitive Recurrent Ovarian Cancer: Making the Most of Emerging Targeted Therapies Mansoor R. Mirza, MD Copenhagen University Hospital Rigshospitalet

More information

Contents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ

Contents 1 The Windows of Susceptibility to Breast Cancer 2 The So Called Pre-Neoplastic Lesions and Carcinoma In Situ Contents 1 The Windows of Susceptibility to Breast Cancer... 1 1.1 Introduction... 1 1.2 Risk Factor and Etiological Agents... 2 1.3 The Concept of the Windows of Susceptibility to Carcinogenesis... 5

More information

Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer

Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer University of Massachusetts Medical School escholarship@umms Open Access Articles Open Access Publications by UMMS Authors 11-16-2017 Computational Investigation of Homologous Recombination DNA Repair

More information

EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY. Dr. Carlos Garbino

EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY. Dr. Carlos Garbino EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY Dr. Carlos Garbino EARLY BREAST CANCER ADJUVANT CHEMOTHERAPY SUSTANTIVE DIFFICULTIES FOR A WORLDWIDE APPLICABILITY DUE TO IMPORTANT INEQUALITIES + IN DIFFERENT

More information

Biobanking of Breast Cancer: Ultimately leading to prevention of brain metastases

Biobanking of Breast Cancer: Ultimately leading to prevention of brain metastases Biobanking of Breast Cancer: Ultimately leading to prevention of brain metastases A.Hoeben, MD PhD Medical Oncologist Content. Introduction: -> need to optimize current treatment options for brain metastasized

More information

Biomarker for Response and Resistance in Ovarian Cancer

Biomarker for Response and Resistance in Ovarian Cancer 2016 대한부인종양학회제 31 차춘계학술대회 New Trends in Translational Research Biomarker for Response and Resistance in Ovarian Cancer Shin-Wha Lee, M.D., Ph.D. Department of Obstetrics and Gynecology ASAN Medical Center

More information