Clinical & Laboratory Assessment
|
|
- Marianna Wilkinson
- 5 years ago
- Views:
Transcription
1 Clinical & Laboratory Assessment Dr Roger Pool NHLS & University of Pretoria Clinical Assessment (History) Anaemia ( haemoglobin) Dyspnoea (shortness of breath) Tiredness Angina Headache
2 Clinical Assessment (History) Leucopenia ( white cell count) Frequent bacterial infections (skin, mouth, throat, chest) Viral infections, TB Infections are atypical, rapidly progressive & difficult to treat Clinical Assessment (History) Thrombocytopenia ( platelet count) Bruising, epistaxis, menorrhagia Bleeding following trauma increased when platelet count < 50 X 10 9 /l Spontaneous bleeding when platelet count < 10 X 10 9 /l Coagulation factor defects ( coagulation factors) Bleeding following dental extraction Deep tissue bleeding Family history
3 Additional History Weight loss, fever Bone pain, left hypochondrial pain Lymphadenopathy Family history Drug history Previous operations Physical Examination Pallor Tachycardia, systolic murmur Jaundice Lymphadenopathy Skin changes purpura, ankle ulcers Nail changes koilonychia Signs of infection Hepatomegaly and/or splenomegaly Neurological examination B 12 neuropathy Optic fundi anaemia, hyperviscosity
4 Figure 6.1 Haematology at a Glance Petechiae (typical of platelet disorders) Do not blanch with pressure Not palpable
5 Laboratory Assessment Full blood count (FBC) Erythrocyte sedimentation rate (ESR) Coagulation profile Bone marrow aspirate & trephine Flow cytometry Chromosome analysis (cytogenetics, FISH) Full Blood Count (FBC) Collected into EDTA (purple stopper) Hb, Hct, red cell count White cell count + differential count Red cell indices (MCV, MCH, MCHC) Platelet count Blood film size and shape of cells, malaria, leukaemia
6 Erythrocyte sedimentation rate (ESR) Measures the rate of fall of a column of red cells in plasma in 1 hour Determined by plasma concentration of proteins Raised in anaemia Non specific indicator of disease activity ESR infection, inflammation, malignancy, pregnancy
7 Bone marrow aspirate and trephine biopsy Indications: Unexplained anaemia, leucopenia or thrombocytopenia Suspected bone marrow infiltration Suspected infection e.g. TB
8 Flow cytometry Technique used to identify antigens on cell surfaces using a laser light and flourescent dyes Used in the diagnosis of leukaemia Used to monitor residual disease after treatment
9 Flow Cytometer Chromosome analysis Chromosome abnormalities are seen in leukaemia and myelodysplastic syndromes FISH (flourescent in situ hybridization) a technique used to identify specific chromosomal abnormalities e.g. translocations
10 Coagulation profile Prothrombin time (PT) measures the extrinsic and common coagulation pathways Prolonged in liver disease, warfarin therapy, DIC Activated partial thromboplastin time (APTT) measures the intrinsic and common pathways Prolonged in liver disease, heparin therapy, DIC, haemophilia
11 Benign Disorders of White Blood Cells
12 Neutrophil Neutrophil leucocytosis Bacterial infection Inflammation Trauma or surgery Tissue necrosis or infarction Neoplasia Haemorrhage or haemolysis Metabolic derangement Myeloproliferative disease Pregnancy Drugs (steroids, G-CSF)
13 Neutropenia Decreased Production General bone marrow failure Aplastic anaemia, myelodysplasia, acute leukaemia, chemotherapy Specific failure of neutrophil production Congenital, cyclical, drug induced Increased Destruction General Hypersplenism Specific Auto-immune Lymphocyte
14 Lymphocytosis Viral infection Certain bacterial infections e.g. pertussis Lymphoproliferative disorders (leukaemia, lymphoma) Lymphopenia HIV infection Hodgkin s lymphoma Auto-immune disease (e.g. SLE) Cortisone therapy Severe bone marrow failure
15 Eosinophil Eosinophilia Allergy Parasitic infestation Chronic skin disease
Abnormal blood counts in children Dr Tina Biss Consultant Paediatric Haematologist Newcastle upon Tyne Hospitals NHS Foundation Trust
Abnormal blood counts in children Dr Tina Biss Consultant Paediatric Haematologist Newcastle upon Tyne Hospitals NHS Foundation Trust Regional Paediatric Specialty Trainees teaching 4 th July 2017 Scope
More informationYear 2002 Paper two: Questions supplied by Jo 1
Year 2002 Paper two: Questions supplied by Jo 1 Question 70 A 25 year old previously well male student presents with recent exertional dyspnoea, epistaxis and bruising. There is no history of medication,
More informationPATHOLOGY & PATHOPHYSIOLOGY
PATHOLOGY & PATHOPHYSIOLOGY DISORDERS OF BLOOD DISORDERS OF BLOOD Disorders of Blood Infections Tumours Nutritional disorders Coagulation disorders Congenital disorders Septicaemia Leukemia Iron deficiency
More informationGP Referral Guidelines. for. South Wales Cancer Network. Document Control Sheet. Specialty/Project Haematological Site Specific Group
GP Referral Guidelines for South Wales Cancer Network Document Control Sheet Organisation South Wales Cancer Network Specialty/Project Haematological Site Specific Group Document Title GP Referral Guidelines
More informationLeukocytosis - Some Learning Points
Leukocytosis - Some Learning Points Koh Liang Piu Department of Hematology-Oncology National University Cancer Institute National University Health System Objectives of this talk: 1. To provide some useful
More informationThere are two main causes of a low platelet count
Thrombocytopenia Thrombocytopenia is a condition in which a person's blood has an unusually low level of platelets Platelets, also called thrombocytes, are found in a person's blood along with red blood
More informationHEFT Pathology Guideline. GP Investigation and Referral Pathways for leucocyte, platelet disturbances and polycythaemia
HEFT Pathology Guideline GP Investigation and Referral Pathways for leucocyte, platelet disturbances and polycythaemia Produced by: Dr Charalampos Kartsios (Consultant Haematologist) and Muhammad Javed
More informationHaematological Cancer Suspected (Adults & Children)
Haematological Cancer Suspected (Adults & Children) Link to NICE guidelines: https://www.nice.org.uk/guidance/ng47 Patient of any age presents with symptoms of possible haematological cancer If 60 years
More informationBorderline cytopenias. Dr Taku Sugai Consultant Haematologist
Borderline cytopenias Dr Taku Sugai Consultant Haematologist Borderline cytopenias Neutropenia Thrombocytopenia Anaemia with normal haematinics Two recent cases of cytopenias Neutropenia ANC of more than
More informationIdiopathic Thrombocytopenic Purpura
Idiopathic Thrombocytopenic Purpura Title of Guideline Contact Name and Job Title (author) Directorate & Speciality Guideline for the management of idiopathic thrombocytopenic purpura Dr S Stokley, Consultant
More informationPreferred Clinical Services for Leading Age Florida August 26-27, 2015
DIAGNOSIS CODING ESSENTIALS FOR LONG-TERM CARE: CHAPTER 3, D CODES DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS AND CERTAIN DISORDERS INVOLVING THE IMMUNE MECHANISM Preferred Clinical Services for Leading
More informationChapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89
Chapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89 Presented by Jennifer Kurkulonis 1 FOUR MAJOR TYPES OF BLOOD CELLS White blood cells
More informationDiseases Of The Blood
Diseases Of The Blood DR. Associate Professor Of Pathology Faculty Of Medicine Ain Shams University Red Blood Cells and Anemia RBC=4-6 million/mm 2 Hb=12-18 g/dl Oxygen Carrying Molecule Hemoglobin Tetramer:
More informationAnaemia / SCD/ Bleeding disorders in Children
Anaemia / SCD/ Bleeding disorders in Children Dr Neil Kennedy Handouts by Steve Graham Learning Outcomes Describe mechanisms of anaemia in Malawian children Discuss important causes of anaemia Describe
More informationClassification of Anaemia
Classification of Anaemia Dr Roger Pool Department of Haematology NHLS & University of Pretoria MEASUREMENT OF HAEMATOCRIT The haematocrit ratio (Hct) is the proportion of blood made up of cells - mainly
More informationHaemostasis & Coagulation disorders Objectives:
Haematology Lec. 1 د.ميسم مؤيد علوش Haemostasis & Coagulation disorders Objectives: - Define haemostasis and what are the major components involved in haemostasis? - How to assess the coagulation status?
More informationDepartment of Medicine, Govt. Dharmapuri Medical College, Tamil Nadu, India * Corresponding author
Original Research Article To evaluate the clinical and etiological profile of patients presenting with pancytopenia in Government Dharmapuri Medical College Hospital, Dharmapuri P. S. Rani 1*, K. Sureshkumar
More informationGeneral approach to the investigation of haemostasis. Jan Gert Nel Dept. of Haematology University of Pretoria 2013
General approach to the investigation of haemostasis Jan Gert Nel Dept. of Haematology University of Pretoria 2013 Clinical reasons to investigate haemostasis Investigating a clinically suspected bleeding
More informationLab Guide Hematology Section Lab Guide
Lab Guide - 2018 Hematology Section Lab Guide Activated Partial Thromboplastin Time (APTT) One tube 2.7 ml citrated blood sample filled up to the mark on the tube label. (Light blue top tube, citrated
More informationIntroduction to Haematology. Prof Roger Pool Department of Haematology University of Pretoria
Introduction to Haematology Prof Roger Pool Department of Haematology University of Pretoria Suggested reading Haematology at a Glance Atul Mehta & Victor Hoffbrand Second Edition Published by Blackwell
More informationr). SUPPLEMENTARY/SECOND OPPORTUNITY EXAMINATION PAPER nnmlbih UNIVERSITY Sophia Blaauw INSTRUCTIONS FACULTY OF HEALTH AND APPLIED SCIENCES
r). nnmlbih UNIVERSITY OF SCIEFICE nnd TECHNOLOGY FACULTY OF HEALTH AND APPLIED SCIENCES DEPARTMENT OF HEALTH SCIENCES QUALIFICATION: BACHELOR OF MEDICAL LABORATORY SCIENCES QUALIFICATION CODE: 08BMLS
More informationGP CME. James Liang Consultant Haematologist. Created by: Date:
GP CME James Liang Consultant Haematologist Date: Created by: Scenario 52 year old European male Fit and well Brother recently diagnosed with diabetes PMHx Nil Social Hx Ex-smoker stopped 5 years ago (20
More informationInterpreting Blood Tests Part 1. Dr Andrew Smith
Interpreting Blood Tests Part 1 Dr Andrew Smith Outline Part 1 (This Week) Introduction Which Tube!?! FBCs U+Es Part 2 (Next Week): More Electrolytes LFTs Clotting Extras Introduction Bloods are a core
More informationDr. Rai Muhammad Asghar Associate Professor Head of Pediatric Department Rawalpindi Medical College
Dr. Rai Muhammad Asghar Associate Professor Head of Pediatric Department Rawalpindi Medical College AN APPROACH TO BLEEDING DISORDERS NORMAL HEMOSTASIS After injury, 3 processes halt bleeding Vasoconstriction
More informationThe Complete Blood Count
The Complete Blood Count (Cartesian Thinking at Its Best) A SEM Image of Normal Human Blood Laurie Larsson February 22, 2010 Anatomy and Philology II Dr. Danil Hammoudi Introduction A complete blood count
More informationHematology 101. Blanche P Alter, MD, MPH, FAAP Clinical Genetics Branch Division of Cancer Epidemiology and Genetics Bethesda, MD
Hematology 101 Blanche P Alter, MD, MPH, FAAP Clinical Genetics Branch Division of Cancer Epidemiology and Genetics Bethesda, MD Hematocrits Plasma White cells Red cells Normal, Hemorrhage, IDA, Leukemia,
More informationWestern Health Specialist Clinics Access & Referral Guidelines
Haematology Specialist Clinics at Western Health: Western Health runs MBS funded Specialist Clinics on a Wednesday and Thursday afternoon at its Sunshine Hospital site for patients who require assessment
More informationPart 1 examination. Haematology: First paper. Tuesday 20 March Candidates must answer all questions. Each question is worth a total of 25 marks.
Part 1 examination Haematology: First paper Tuesday 20 March 2018 Candidates must answer all questions. Each question is worth a total of 25 marks. Time allowed: 3 hours Question 1: General Haematology
More informationPathology Service User Guide Haematology
Pathology Service User Guide Haematology Worthing This section of the Pathology Service User Guide includes: Routine haematology Immunology Haematinic investigations Haemoglobinopathy screening Bone marrow
More informationGuidelines for Shared Care Centres and Community Staff
Reference: CG1410 Written by: Dr Jeanette Payne Peer reviewer Dr Jenny Welch Approved: February 2016 Approved by D&TC: 8th January 2016 Review Due: February 2019 Intended Audience This document contains
More informationDr. Hasan Fahmawi, MRCP (London), FRCP(Edin) Consultant Physician ANAEMIA
Dr. Hasan Fahmawi, MRCP (London), FRCP(Edin) Consultant Physician ANAEMIA Definition Anaemia refers to a state in which haemoglobin in the blood is below the reference range appropriate for age and
More informationRory McCulloch. Specialty Trainee Haematology Royal Devon & Exeter Hospital
Rory McCulloch Specialty Trainee Haematology Royal Devon & Exeter Hospital Anaemia 1 Haematological disorders Anaemia 2 Non-haematological disorders Substrates: Iron, folate, vitamin B12 Red cell mass
More informationQUESTIONS OF HEMATOLOGY AND THEIR ANSWERS
QUESTIONS OF HEMATOLOGY AND THEIR ANSWERS WHAT IS TRUE AND WHAT IS FALSE? Questions 1 Iron deficiency anemia a) Is usually associated with a raised MCV. b) The MCH is usually low. c) Is most commonly due
More informationFBC CASES Vernon Louw Clinical Haematology 2010
FBC CASES Vernon Louw Clinical Haematology 2010 FOR EACH OF THE FOLLOWING PATIENTS, SELECT THE MOST LIKELY FINDING FROM THE ANALYSIS OF THE PERIPHERAL BLOOD. A patient with infectious mononucleosis. A
More informationMorphology Case Study. Presented by Niamh O Donnell, BSc, MSc. Medical Scientist Haematology Laboratory Cork University Hospital
Morphology Case Study Presented by Niamh O Donnell, BSc, MSc. Medical Scientist Haematology Laboratory Cork University Hospital 41 year old male presented to GP for routine check-up in May 2011. FBC Results:
More informationAnemia (3).ms4.25.Oct.15 Hemolytic Anemia. Abdallah Abbadi
Anemia (3).ms4.25.Oct.15 Hemolytic Anemia Abdallah Abbadi Case 3 24 yr old female presented with anemia syndrome and jaundice. She was found to have splenomegaly. Hb 8, wbc 12k, Plt 212k, retics 12%, LDH
More informationCytopaenias in HIV. Dr Maresce Bizaare Specialist Physician Clinical Haematology Fellow IALCH
Cytopaenias in HIV Dr Maresce Bizaare Specialist Physician Clinical Haematology Fellow IALCH Introduction Cytopaenias in HIV are common Anaemias multifactorial causes Thrombocytopaenias may be the first
More informationCommon Haematological Problems in Primary Care
23 rd March 2019 GP Hot Topics In Primary Care Common Haematological Problems in Primary Care Dr Samar Kulkarni Consultant Haematologist-Oncologist and The Christie Private Care Manchester, UK. Haematology?
More informationKing s Health Partners Haematology Institute and Network GP Referral Guide, Adult Haematology
King s Health Partners Haematology Institute and Network GP Referral Guide, Adult Haematology 1 Version control: There are two controlled versions of this document, one for GSTT and one for KCH. While
More informationTaking The Fear Out of Abnormal CBC s Problems of Production, Destruction or loss
Taking The Fear Out of Abnormal CBC s Problems of Production, Destruction or loss Joanne Eddington, MN, FNP, AOCN Providence Oncology and Hematology Care Clinic - Eastside Blood Cell Abnormalities Abnormalities
More informationPart 1 examination. Haematology: First paper. Tuesday 25 September 2018
Part 1 examination Haematology: First paper Tuesday 25 September 2018 Candidates must answer all questions. Each question is worth a total of 25 marks. Time allowed: 3 hours 1. Haemato-oncology. A 22 year
More informationBeyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure
Beyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure I am receiving an honorarium from Sysmex for today s presentation. 1 Determining the Etiology for
More informationHaematology Team431 3/4. White Blood Cells. Abdulrahman Alkadhaib & Alaa Alanazi. Mohammed Page 1 Al-Dhaheri
3/4 White Blood Cells Abdulrahman Alkadhaib & Alaa Alanazi Mohammed Page 1 Al-Dhaheri Red color = Important information Blue color = Additional notes Objectives: Identify the types of white blood cells
More informationProblem Based Learning
Problem Based Learning 2 Dania Qarqash&OmaymaHassanin Enas Ajarma Dr.Hikmat Abdel-Razeq Clinical hematology is divided into four subjects : 1- Benign hematology Anemia Benign WBC disorders Bone marrow
More informationGUIDELINE: ASSESSMENT OF BRUISING & BLEEDING IN CHILDREN. All children in whom there is concern regarding bruising / bleeding
GUIDELINE: ASSESSMENT OF BRUISING & BLEEDING IN CHILDREN Reference: Bruising / Bleeding / NAI Version No: 1 Applicable to All children in whom there is concern regarding bruising / bleeding Classification
More informationTable 8.1. Epidemiology of Leukemia in the United States (2010) Annual Deaths. Mean Age. Percentage of All Leukemias (%) (Number of New Cases)
Table 8.1. Epidemiology of Leukemia in the United States (2010) Type of Leukemia Annual Incidence (Number of New Cases) Percentage of All Leukemias (%) Annual Deaths Mean Age Acute lymphocytic 5,330 12
More informationThe patient had a mild splenomegaly but no obvious lymph node enlargement. The consensus phenotype obtained from part one of the exercise was:
Case History An 86 year old male was admitted to hospital with chest infection. Haematological examination subsequently revealed the following: Hb- 11.0 g/dl; WBC- 67.1 x 10^9/l; PLT- 99 x10^9/l; RBC-
More informationMichael Joffe ST6 Haematology SpR
Michael Joffe ST6 Haematology SpR Mrs SB 71 year old female on AMU Telephone referral to haematology by medicine with Hb 102 MCV 89, normal B12, Folate, Ferritin. PMH DM General decline over several weeks
More informationContents SECTION 1: PHYSIOLOGY OF BLOOD
Contents SECTION 1: PHYSIOLOGY OF BLOOD Chapter 1: Overview of Physiology of Blood 1 Normal Haematopoiesis 1 Red Blood Cells 6 White Blood Cells 15 Immune System 27 Megakaryopoiesis 32 Normal Haemostasis
More informationCollect and label sample according to standard protocols. Gently invert tube 8-10 times immediately after draw. DO NOT SHAKE. Do not centrifuge.
Complete Blood Count CPT Code: CBC with Differential: 85025 CBC without Differential: 85027 Order Code: CBC with Differential: C915 Includes: White blood cell, Red blood cell, Hematocrit, Hemoglobin, MCV,
More informationPlatelet and WBC disorders
Division of Family Practice Platelet and WBC disorders Adrian Yee MD FRCPC Clinical hematologist Assistant Dean, undergraduate education, IMP asyee@uvic.ca When we understand that slide, we'll have won
More informationKing s Health Partners Haematology Institute and Network GP Referral Guide, Adult Haematology
King s Health Partners Haematology Institute and Network GP Referral Guide, Adult Haematology For two week wait pathway, please continue to use existing documentation/pathways. Telephone advice and guidance
More informationHaemorrhagic Disorders. Dr. Bashar Department of Pathology Mosul Medical College
Haemorrhagic Disorders Dr. Bashar Department of Pathology Mosul Medical College Hemorrhagic Disorders These include Disorders of platelets. Disorders of blood vessels. Disorders of coagulation & fibrinolysis.
More informationBio& 242 Unit 3 / Lecture 1
Bio& 242 Unit 3 / Lecture 1 Major Functions of Blood The body contains 4 to 6 liters of blood with an average ph of 7.35 to 7.45. Functions include: Transport Oxygen, Carbon Dioxide, Nutrients, Hormones,
More informationApproach to a pale child
Approach to a pale child Dr. Dafalla Ahmed Babiker Jazan university objectives Definition of anemia Classification and causes Important points in history and physical examination Investigations. Definition
More informationDr. MUBARAK ABDELRAHMAN MD PEDIATRICS AND CHILD HEALTH Assistant Professor FACULTY OF MEDICINE -JAZAN
Dr. MUBARAK ABDELRAHMAN MD PEDIATRICS AND CHILD HEALTH Assistant Professor FACULTY OF MEDICINE -JAZAN The student should be able:» To identify the mechanism of homeostasis and the role of vessels, platelets
More informationPathology of Hematopoietic and Lymphoid tissue
CONTENTS Pathology of Hematopoietic and Lymphoid tissue White blood cells and lymph nodes Quantitative disorder of white blood cells Reactive lymphadenopathies Infectious lymphadenitis Tumor metastasis
More informationFull Blood Count analysis Is a 3 part-diff good enough? Dr Marion Münster, Sysmex South Africa
Full Blood Count analysis Is a 3 part-diff good enough? Dr Marion Münster, Sysmex South Africa The Role of the FBC in clinical decision making History Examination Investigations Decision 70% FBC Laboratory
More informationHEME 10 Bleeding Disorders
HEME 10 Bleeding Disorders When injury occurs, three mechanisms occur Blood vessels Primary hemostasis Secondary hemostasis Diseases of the blood vessels Platelet disorders Thrombocytopenia Functional
More information12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
Table of Contents: PART I: Molecular and Cellular Basis of Hematology 1 Anatomy and Pathophysiology of the Gene 2 Genomic Approaches to Hematology 3 Regulation of Gene Expression, Transcription, Splicing,
More informationDisorders of Blood Cells & Blood Coagulation
Disorders of Blood Cells & Blood Coagulation HIHIM 409 WBC count RBC count WBC differential Hemoglobin (HGB) Hematocrit (HCT) % of volume occupied by RBCs CBC Red cell indices Mean cell volume (MCV) average
More informationAnemia (3).ms Hemolytic Anemia. Abdallah Abbadi Feras Fararjeh
Anemia (3).ms4.26.2.18 Hemolytic Anemia Abdallah Abbadi Feras Fararjeh Case 3 24 yr old female presented with anemia syndrome and jaundice. She was found to have splenomegaly. Hb 8, wbc 12k, Plt 212k,
More informationBlood Transfusion Guidelines in Clinical Practice
Blood Transfusion Guidelines in Clinical Practice Salwa Hindawi Director of Blood Transfusion Services Associate Professor in Haematology and Transfusion Medicine King Abdalaziz University, Jeddah Saudi
More informationBleeding Disorders. Dr. Mazen Fawzi Done by Saja M. Al-Neaumy Noor A Mohammad Noor A Joseph Joseph
Bleeding Disorders Dr. Mazen Fawzi Done by Saja M. Al-Neaumy Noor A Mohammad Noor A Joseph Joseph Normal hemostasis The normal hemostatic response involves interactions among: The blood vessel wall (endothelium)
More informationHaemopoiesis. Matthew Hazell Consultant Clinical Scientist Trainee
Haemopoiesis Matthew Hazell Consultant Clinical Scientist Trainee Learning objectives Describe haemopoiesis and the development of blood cells from stem cells to mature cells Explain the roles of the different
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Haematology & Blood Transfusion Contact: Neil Wrathall The Christie Tel: +44 (0) 161 918 7264 Wilmslow Road Fax: +44 (0) 161 446 8549 Manchester
More informationEvaluation of Anemia. Md. Shafiqul Bari Associate professor (Medicine) SOMC
Evaluation of Anemia Md. Shafiqul Bari Associate professor (Medicine) SOMC Definition Anemia is operationally defined as a reduction in one or more of the major RBC measurements Hemoglobin concentration
More informationFBC interpretation. Dr. Gergely Varga
FBC interpretation Dr. Gergely Varga #1 71 Y/O female, c/o weakness Test Undertaken : FBC (FBC) Sample Type: Whole Blood [ - 26.09.11 14:59] Hb 7.3 g/dl* 12.0-15.5 RBC 3.5 10^12/l * 3.80-5.60 Hct 0.24
More informationHAEMATOLOGICAL MALIGNANCY
HAEMATOLOGICAL MALIGNANCY Reference Compulsory reading Haematology at Glance 2 nd ed. Atul Mehta & Victor Hoffbrand Chapters: 20 to 31 Pages: 46 to 69 Pathogenesis of Haematological Malignancy Figure (a)
More information٢٨/٠١/١٤٣٧. Prof. M. Rushdi.
١ PARAMETERS OF LEUCOCYTES PICTURE TtlWBC Total WBCs count Differential LC Hemocytometer Blood film Blood Cell Counter Blood Cell Counter INTERPRETATION OF LEUCOCYTES PICTURE 1.Leucocytosis. 2. Leucopenia.
More informationAdult Acute leukemia. Matthew Seftel. August
Adult Acute leukemia Matthew Seftel August 21 2007 mseftel@cancercare.mb.ca Principles 3 cases Diagnosis and classification of acute leukemia (AL) Therapy Emergencies Remission induction BMT Complications
More informationLeukocyte Disorders. Dr Alauldeen Mudhafar Zubair
Leukocyte Disorders Dr Alauldeen Mudhafar Zubair Composition of blood Specialized connective tissue Blood cells (formed elements) suspended in plasma Blood volume: 5-6 liters (approx 1.5 gal) in males
More informationChapter 4. M.G.Rajanandh, Department of Pharmacy Practice, SRM College of Pharmacy, SRM University.
Chapter 4 M.G.Rajanandh, Department of Pharmacy Practice, SRM College of Pharmacy, SRM University. RBC (Erythrocytes): RBC COUNT: NORMAL VALUES: For men: 4.3-5.9 millions/mm 3 of blood. For women: 3.5-5.0
More informationComplete Blood Count PSI AP Biology
Complete Blood Count PSI AP Biology Name: Objective Students will examine how the immunological response affects molecules in the blood. Students will analyze three complete blood counts and create diagnoses
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Department of Haematology and Blood Transfusion 3 rd Floor Pathology Directorate Darent Valley Hospital Darenth Wood Road Dartford Kent DA2
More informationRed cell disorder. Dr. Ahmed Hasan
Red cell disorder Dr. Ahmed Hasan Things to be learned in this lecture Definition and clinical feature of anemia. Classification of anemia. Know some details of microcytic anemia Question of the lecture:
More informationWHAT IS YOUR DIAGNOSIS?
WHAT IS YOUR DIAGNOSIS? A 1.5 year, male neuter, domestic shorthair cat was presented to the R(D)SVS Internal Medicine Service with a three month history of pica (ingestion of cat litter and licking concrete)
More information2017 Repeat Audit of Red cell and Platelet Transfusion in Adult Haematology Patients
07 Repeat Audit of Red cell and Platelet Transfusion in Adult Haematology Patients Haematology Audit July 07 The audit was conducted on adults undergoing surgery and who received a transfusion during a
More informationGuidelines on the Management of a Child with Sickle Cell Disease and low Haemoglobin
Guidelines on the Management of a Child with Sickle Cell Disease and low Haemoglobin Version: 6 Date: 2 nd March 2010 Authors: Responsible committee or Director: Review date: Target audience: Stakeholders/
More informationSouth African HIV Clinicians Society Managing adult treatment through case study discussion
South African HIV Clinicians Society Managing adult treatment through case study discussion Jade Mogambery Grey s Hospital, Pietermaritzburg Infectious Diseases Unit Referral summary 20-year-old male HIV
More informationDisclosures/COI. Cases in Hematopathology. Outline. Heme Path Findings Not to Miss. Normal Peripheral Smear 6/30/2016
Disclosures/COI Cases in Hematopathology Vamsi Kota Assistant Professor Department of Hematology & Medical Oncology Leukemia/BMT I have no disclosures or conflicts of interest regarding this presentation.
More informationPCCN Review Hematology
PCCN Review Hematology Leanna R. Miller, RN, MN, CCRN-CMC, PCCN-CSC CEN, CNRN, CMSRN, NP Education Specialist LRM Consulting Nashville, TN Anemia Definition reduction in RBC concentration Causes iron deficiency
More informationDrop of Blood Unravels Mysteries. Prof. Salma Afrose Department of Hematology Dhaka Medical College
Drop of Blood Unravels Mysteries Prof. Salma Afrose Department of Hematology Dhaka Medical College Peripheral Blood Film (PBF) PBF is a laboratory workup that involves cytology of Peripheral blood cell
More informationComplete Blood Count in Primary Care
QUIZ FEEDBACK Complete Blood Count in Primary Care bpac nz better medicine GP Review Panel: Dr Janine Bailey, Motueka Dr Susie Lawless, Dunedin Dr Randall Sturm, Auckland Dr Neil Whittaker, Nelson Specialist
More informationBleeding disorders. Hemostatic failure: Inappropriate and excessive bleeding either spontaneous or in response to injury.
1 Bleeding disorders Objectives: 1. Discuss briefly the physiology of hemostasis. 2. Define the mechanisms of thrombocytopenia and the relative bleeding risk at any given platelet count. 3. Be able to
More informationCOAGULATIONS. Dr. Hasan Fahmawi, MRCP(UK), FRCP(Edin)
COAGULATIONS Dr. Hasan Fahmawi, MRCP(UK), FRCP(Edin) Haemostasis-blood must be maintained in a fluid state in order to function as a transport system, but must be able to solidify to form a clot following
More informationBone marrow failure. By Zahraa Nasooh Al_Saaty
Bone marrow failure By Zahraa Nasooh Al_Saaty Pancytopenia : Pancytopenia describes a reduction in the blood count of all the major cell lines-red cells,white cell and platelets. It has several causes
More informationPathology of Hematopoietic and Lymphoid tissue
Pathology of Hematopoietic and Lymphoid tissue Peerayut Sitthichaiyakul, M.D. Department of Pathology and Forensic Medicine Faculty of Medicine, Naresuan University CONTENTS White blood cells and lymph
More informationAutoimmune lymphoproliferative syndrome (ALPS)
ALPS Autoimmune lymphoproliferative syndrome (ALPS) Information for families hello@piduk.org 0800 987 8986 www.piduk.org About this leaflet This leaflet is designed to help answer the questions families
More informationChapter 46. Care of the Patient with a Blood or Lymphatic Disorder
Chapter 46 Care of the Patient with a Blood or Lymphatic Disorder All items and derived items 2015, 2011, 2006 by Mosby, Inc., an imprint of Elsevier Inc. All rights reserved. Components of the Blood Red
More informationHaematological Emergencies (Part 1) Ray Mun Koo Haematology Advanced Trainee Canberra Hospital
Haematological Emergencies (Part 1) Ray Mun Koo Haematology Advanced Trainee Canberra Hospital Case Number 1 43 year old male presenting with fevers, abdominal distension and weight gain over 2 weeks.
More informationPlatelet Disorders. By : Saja Al-Oran
Platelet Disorders By : Saja Al-Oran Introduction The platelet arise from the fragmentation of the cytoplasm of megakaryocyte in the bone marrow. circulate in the blood as disc-shaped anucleate particles
More informationThe LaboratoryMatters
Laboratory Medicine Newsletter for clinicians, pathologists & clinical laboratory technologists. A Initiative. HEMOSTASIS AND THE LABORATORY This issue highlights: Primary Hemostasis Screening Tests Case
More informationChapter 3 MAKING THE DECISION TO TRANSFUSE
Chapter 3 MAKING THE DECISION TO TRANSFUSE PRACTICE POINTS Determine the best treatment for the patient which may include transfusion. Treat the cause of cytopenia (anaemia or thrombocytopenia) or plasma
More informationCandidates must answer ALL questions
Time allowed: Three hours. Part 1 examination Haematology: First paper Tuesday 22 March 2016 Candidates must answer ALL questions Question 1: General Haematology A 16 year old non-european is referred
More informationDairion Gatot, Soegiarto Ganie, Savita Handayani. Divisi Hematologi & Onkologi Medik Departemen Ilmu Penyakit Dalam FK-USU/RS H.Adam Malik Medan 2009
HAEMOLYTIC ANAEMIA Dairion Gatot, Soegiarto Ganie, Savita Handayani. Divisi Hematologi & Onkologi Medik Departemen Ilmu Penyakit Dalam FK-USU/RS H.Adam Malik Medan 2009 WHEN BY THEN Hb 9 g% transfusion
More informationAPPROACHING TO PANCYTOPENIA
APPROACHING TO PANCYTOPENIA P A T C H A R E E K O M V I L A I S A K, M. D. A S S I S T A N T P R O F E S S O R D I V I S I O N O F P E D I A T R I C H E M A T O L O G Y O N C O L O G Y, D E P A R T M E
More informationHematology HISTORY TAKING
Hematology HISTORY TAKING Abnormalities of the blood are associated with a wide range of symptoms and these are discussed in detail under diagnostic headings in subsequent parts of the book. The intention
More informationHaematology for GP's
Haematology for GP's Dr Christina Zouvelou Consultant Haematologist SOUTHEND UNIVERSITY HOSPITALS NHS FT SPIRE WELLESLEY HOSPITAL Time to Learn, 03/07/2018 Anaemia Careful history (duration, symptoms,
More informationWHAT ARE PAEDIATRIC CANCERS
WHAT ARE PAEDIATRIC CANCERS INTRODUCTION Childhood cancers are RARE 0.5% of all cancers in the West Overall risk that a child will develop cancer during first 15 years of life is 1 in 450 and 1 in 600
More information