COURSE CHANGE PROPOSAL USC Columbia, Lancaster, Salkehatchie, Sumter & Union campuses

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1 ... COURSE CHANGE PROPOSAL USC Columbia, Lancaster, Salkehatchie, Sumter & Union campuses CCP INSTRUCTIONS: This form is used to make changes to a course number. title, 4-letter designator. credit hours, pre- or co-requisites, description, delivery location or delivery method, or to delete a course. If the change affects the interests of another unit or campus, letters of concurrence from those units must be attached. The form is available online at Date: 11/3/14 Campus: --=-C...::.O=L'-=UMB==-=IA=-= College/School: SCHOOL OF MEDICINE Department (if applicable): ----=-:PMI= D Undergraduate ~Graduate OLD COURSE INFORMATION Course Designation: 4-letter Designator Prefix Course Number Suffix # Credit Hours: D Variable ~Fixed #Times Course Can Be Taken:.:1::: Course Title (24 Character limit): Introductory General and Organ System Pathology for Graduate Students Cross-listed with which course? 4-letter Designator Prefix Course Number Suffix Course Prerequisites/Corequisites: ---=-:N:..::O:.:.NE.:.:::::... a Course Delivery location: rgj USC Campus D Off-Campus site (If an off-campus delivery change is being requested, attach a completed Off-Campus l)elivery (OCD) form) Course Delivery Method: ~Traditional Delivery D Distance Technology Delivery (strearringvideo, wel>-based, Co/ovo) (If distance technology delivery is being requested attach a completed Distance Education Delivery (OED) form.) PROPOSED CHANGE RECEIVED Proposed Effective Term- Change to database/bulletin effective no sooner than: Year: Fall ~ Spring D May Session 0 Summer I 0 Summer II OCT D Delete Course rgj Change Course Title to: USC Graduate Schoof D Change Course Designator to: OC~~eCoorseNum~r~ : ~N~~~ Add or Change Cross Listing: ~N~/A~ CI Change Credit Hours to: D Change Prerequisites/Corequisites to: ~N~/A:..;: rgj Change Course Description/Content (Please attach a completed two-column Bulletin Change Form.) D Add or Change Delivery Location (Please attach a completed Off-Campus Delivery (OCD) Form.) D Add or Change Delivery Method to Distance Education (Please attach a completed Distance Education Delivery (OED) Form.) 0 Change Grading System to : rgj Other Change (Specify): IOULIA CHA TZIST AMOU (instructor) VIP ID number: I l q 5 lf 011

2 CCP-Page 2 IMPACT ON OTHER ACADEMIC UNITS & CAMPUSES Does the proposed course affect the curriculum, students or academic interest of any other unit at USC Columbia 0 or on a USC Regional Campus? Yes ~ No Identify which unit(s)/campus(es) (Ifyes, please attach letters of concuffence from relevant units and/or the Office of System Affairs.) REQUIRED ATTACHMENTS (The following documents as appropriate must be attached to this form before submission) "Before" and "After" Course Syllabi required only for these actions: - Course description change -Course title change, if it implies substantially new content - Change in course level from undergraduate to graduate, or vice versa ~ Course syllabi (see for syllabus component guidelines and template syllabus) ~ "Before" and "After" bulletin description on two-column Bulletin Change Form (BCH) ~ Justification Form (JUS) 0 Letters of concurrence (if appropriate) CONTACT INFORMATION Contact Person: IOULIA CHA TZISTAMOU CLIN. ASSISTANT PROF. Print name Title chatzistamou@uscmed.sc.edu (803) Address Phone Number Ioulia Chatzistamou ll /311 4 Signature Date REQUIRED APPROVALS Department Chair: 10/21114 Mitzi Nagarkatti Print name m~h..l "IA1tzrkA..ffa~u S.LIV't4-sc... -d.(.(, Qt lle. 3lfOO Addre Academic Dean: ::fcshllb...i N>rn hi II, MD Print name Date Signattre Phone Number ~ ~ --:los.h!i.a:rb:c.n b: tleus uil-~. sc..-tcj u.. Address FacSenate Cours&Curricl Dean of the Graduate ,P.,..,rin-t-na_m_e School (as appropriate) /o/:lf/n Date SignatiKe ~ 1,.,. 3 & o o Phone Number Date Signature Phone Number Address 0 Graduate Council 0 Faculty Senate Date of Faculty Governance Approval (if appropriate) University of South Carolina I Provost Office I CCP Fonn Oct 2010 v3

3 ~~~~~~~~~~~~~~~ BULLETIN CHANGE FORM USC Columbia, Lancaster, Salkehatchie, Sumter & Union campuses BCH INSTRUCTIONS: This form is normally used to accompany a program or course action form. If the requested change is minor, non-substantive, or editorial, this form may be used alone without other forms. Please insert or attach the proposed language changes exactly as they are to appear in the Bulletin. A two-column format showing both the old wording (left column) and the new wording (right column) is required. This form is available online at Date: 11/3/14 Campus: COLUMBIA College/School: SCHOOL OF MEDICINE Department (if applicable): _P_MI D~~Progrnm~ap~~~~:~G=~=~U=A=T=E~ Proposed Effective Term- Change to database/bulletin effective no sooner than: Year: 2015 I Fall IX Spring I May Session I Summer I I Summer II Bulletin Version: IX Graduate I Undergraduate Bulletin Section (if applicable): Internet or web link to Bulletin Entry: CURRENT BULLETIN LANGUAGE (text to be deleted in new version show as strikethrough) NEW LANGUAGE OR PROPOSED CHANGE TO BULLETIN Please note that text should be formatted in Word to show strikethrough. Then, cut and paste the text into the space below. (new text shown as underlined) - Introduction to General and Organ System Pathology Credits: 3 Basic principles of pathologic processes of disease in organs and tissues at the gross and microscopic level. A review of normal anatomy and histology essential to an understanding of processes and organs and tissues that were normal before the disease began. - Experimental Pathology Credits: 3 An introduction to the basic principles of Experimental Pathology and the description of methodologies, including the generation of experimental mouse models for various diseases. Review of the normal anatomy and histology and of the pathologic processes of disease in organs and tissues at the gross and microscopic level. CONTACT INFORMATION Contact Person: IOULIA CHATZISTAMOU Print name chatzistamou@uscmed.sc.edu Address Title Phone Number lo Signature REQUIRED APPROVALS Office with Authority for Bulletin Section: CLIN. ASSIST. PROF. Date (for Bufletin Changes not associated with an academic program or curriculum) Print name Address Signature Date Phone Number University of South Carolina I Provost Office I Bulletin Change Form Oct 2010 v4

4 JUSTIFICATION FORM USC Columbia, Lancaster, Salkehatchie, Sumter & Union campuses JUS INSTRUCTIONS: Please attach a statement explaining the justification for the proposed program or course action. This form is available online at Date: 11/3/14 Campus: COLUMBIA --~~~~~~ College/School: SCHOOL OF MEDICINE Departme~~ap~ica~~: ~P-~~~~~~~~~~~~~~~~~~~~~~~~ Degree Program (if applicable): 0 Undergraduate IZI Graduate Intergrated BMSC and Certificate in BMSC programs It was found that the contents of the previous course wherein the focus was didactic teaching of some of the topics was not favorable to both the certificate program students and the graduate students. I have to mention at this point the previous course was never taught so far, for various reasons. Thus, upon the recommendation of the Chair of the Department of Pathology, Microbiology and Immunology, we are considering changing the contents and the title of the graduate course, which I will be directing. Although this proposal is not actually a "new" course, I would like to bring to the attention of the committee the fact that the suggested changes, will offer a different approach of the pathology to the students, based on the contemporary experimental pathology. The contents of the already existing course, was mainly to offer an introductory background in the classical pathology that is descriptive and its main resources are the microscopic examination of cells and tissues. Though it was a well formed and organized course, the current course will be formulated to provide a more experimental approach of pathology that will focus on the laboratory investigation of disease mechanisms. By using a variety of techniques and methodologies, experimental pathology analyzes the factors that cause deregulation of cellular processes and attempts to identify how they affect normal function. Furthermore, by manipulating animals at the genetic and cellular level stimulates pathological conditions generating experimental models for various diseases appropriate to study basic biological processes as well as drug's efficiency. It has been recognized for some time that many graduate students in the life sciences know very little about human diseases and their pathogenesis. This is clearly a problem given the disease focus of much of National Institutes of Health (NIH} funding for biomedical research. So, the suggested changes aim to offer to the graduate and other interested students enrolled in the Post-Baccalaureate Certificate Program, training in experimental pathology by studying basic pathological entities with distinct histological manifestations and describe relevant animal models simulating the development of human disease. The students will also be exposed to human pathologic disease processes at the etiologic, pathogenetic, gross, and microscopic levels, so as to serve as a supporting adjunct to their academic activities in the field of pathobiology, equipping them with a firm grounding in the morbid anatomy and histopathology of significant human disease processes. The goal of the course is to provide the meaning of pathology to the graduate students and enhance mandatory interaction between pathologists and non-medical investigators (i.e. graduate degree candidates in the biomedical sciences). The pathologic basis of human disease, with a clear conception of both the structural and the functional changes with respect to normal anatomy and histology caused by disease in tissues and organs, as a basis for understanding the clinical manifestations and principles of treatment, as well as the exposure of the students to the experimental approach of pathology will strengthen their background in the biomedical sciences and will help them understand how the discipline of pathology interfaces with science and medicine. University of South Carolina I Provost Office I Justification Form Oct 2010 v3

5 l DEFINITIONS Pathology: Pathology is the study of the essential nature of diseases and especially of the structural and functional changes at the molecular, cellular, tissue and organ level, and stands at the interface between medicine and biology. Experimental Pathology: Experimental Pathology is a subdivision of Pathology that in contrast to the Classic Pathology that is primarily descriptive uses a variety of techniques and methodologies in order to analyze the factors that cause deregulation of cellular processes and attempts to identify how they affect normal tissue function. COURSE DESCRIPTION Pathology is the study of disease at the molecular, cellular, tissue and organ level, and stands at the interface between medicine and biology. While classical pathology is conventionally descriptive and relies primarily in the microscopic examination of cells and tissues, contemporary pathology is experimental and is concerned with the cause-effect relationship between the disease-causing agent and its specific manifestations. In addition, contemporary experimental pathology focuses on the laboratory investigation of disease mechanisms. By using a variety of techniques and methodologies experimental pathology analyzes the factors that cause deregulation of cellular processes and attempts to identify how they affect normal tissue function. Furthermore, by manipulating animals at the genetic and cellular level simulates human pathological conditions generating experimental models for various diseases appropriate to study basic biological processes as well as drugs' efficiency. Our program focuses on the study of basic pathological entities with distinct histological manifestations and describes relevant animal models recapitulating the development of human disease. The course will provide the learner with a fundamental biomedical knowledge base in human pathology, and will provide an introduction to the study of the histopathology of disease. Particular emphasis will be given to the etiology (causes), pathogenesis (mechanisms), and description of gross and microscopic pathologic patterns occurring during the progress and outcome of major human diseases and conditions. Disease processes will be UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

6 observed at the macroscopic level through detailed inspection of fixed tissue in gross specimens as well as at the microscopic level. The students will also have the opportunity to review histology slides of various organs and entities by using common optical microscope under the guidance of the instructor. With the knowledge of normal histology and by gaining familiarity of microscopic appearances through direct observation the students will develop observational and descriptive skills - and ultimately deepening to the understanding of the underlying mechanisms of disease, thus facilitating opportunities to explore and exploit basic science questions related to disease. In addition by the description of the experimental methodologies including the mouse models of various diseases, they will formulate the causative approach in the study of disease. Basic information regarding anatomy, histology, embryology, immunity, molecular biology, and genetics is introduced, in recognition of the fact that problem-based learners may struggle with concepts for the want of fundamental prerequisite knowledge. The approach of the normal anatomy and histology that is going to be included wherever appropriate, will be based on an online self-guided histology tutorial (Boston University School of Medicine histology learning portal at as well as a supplementary textbook (and online) learning resource (Kierszenbaum AL, Tres LL. Histology and Cell Biology: An Introduction to Pathology. 3rd Edition. Mosby Elsevier, ISBN ). A complete syllabus and learning objectives (intended learning outcomes) will be provided, in addition to a correlative study guide. The course will be divided into two blocks of learning modules: ~~General Aspects of Pathology", and 11 Pathology of Disease with emphasis in Neoplasia". ~~General Aspects of Pathology" consists of a series of learning modules that deal with pathologic forces that can affect any part of the body: the life and death of cells, inflammation and repair, diseases of the immune system, infectious diseases and neurodegenerative diseases. ~~Pathology of Disease with emphasis in Neoplasia" includes learning modules that will cover the histopathology of major human diseases and cancers such as in breast, female genital tract, lung, colon and prostate and will describe their experimental approach mostly through the development of mouse models. Upon completion of this course, the student should be able to identify the fundamental pathologic characteristics of common diseases and conditions, based upon their etiology, pathogenesis, and gross and microscopic pathologic patterns. Furthermore they will be able to design experimental studies aiming to characterize and validate disease models. This is a 1-semester 3-credit elective course that will meet twice weekly, each session for 75 minutes. This course is open for enrollment to graduate students in the University of South Carolina School of Medicine Integrated Biomedical Science (BMSC) program as well as to postbaccalaureate students in the Certificate in Biomedical Sciences program. Didactic resources will include: lecture presentations with use of effective teaching analogies and visual mnemonics, where appropriate, to teach basic concepts, illustrative cases, UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

7 microscopic slides, and plastinated gross museum specimens, as well as medical library access to the Web Path Internet learning laboratory platform at For purposes of formative assessment, interactive pretest review sessions with incorporation of audience response system practice high-yield multiple-choice items will be incorporated during the course of teaching and learning sessions. The lectures will emphasize key points and key morphological concepts with abundant visual imagery, and have as a major objective learning the language of pathology; that is, the recognition of structural alterations as they effect changes on cellular and tissue function, ultimately leading to disease. READINGS AND EDUCATIONAL RESOURCES Course Documents: These will be posted to Blackboard 9.1 and contain the basic information about the course including goals, general and specific objectives, lecture schedule, examination information, grading policies, departmental rules and guidelines, course director's contact information, etc. The student is urged to refer to this document on a regular basis. Textbooks: As the graduate student cohort has traditionally been found to rely more heavily than undergraduates or other allied health professionals on assigned reading for core educational content, the following textbooks are recommended to students for this course: Damjanov I. Pathology for the Health Professions. 4th Edition. Saunders Elsevier, ISBN and Conn M.P. (ed.) Sourcebook of Models for Biomedical Research. Humana Press, ISBN: and the following textbooks are suggested as an ancillary learning resource: Rubin E and Reisner HM (eds.). Essentials of Rubin's Pathology. 5th Edition. Lippincott Williams & Wilkins/Welters Kluwer Health, ISBN Teicher B.A. (ed.) Tumor,Models in Cancer Research. zth Edition. Humana Press, ISBN: These textbooks will be made available as well for consultation in the medical library, as will UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

8 _, the following basic histology reference: Kierszenbaum AL, Tres LL. Histology and Cell Biology: An Introduction to Pathology. 3 rd Edition. Mosby Elsevier, ISBN EVALUATING STUDENT KNOWLEDGE AND PERFORMANCE Examination guidelines and policies for this course are implemented as outlined. Midterm Examination/Final Examination: Summative assessment will be based on a mid-term examination and a final examination, each structured as National Board of Medical Examiners (NBME)-style multiple-choice items. Exam questions will originate from the topics covered in lectures. The lectures are designed to cover the important major topics. The questions will be selected to emphasize definitions, basic concepts, and the pathology of disease processes. The final grade will be based on the cumulative total of the mid-term and final examinations with no difference in weighting. Grades will be assigned as follows: A= % B = 70-84% c = 60-69% D = 50-59% F = 49% and below FACULTY Dr. loulia Chatzistamou (PM I, Course Director) and faculty members of the Dept of PM I, School of Medicine COURSE SCHEDULE The topics (concept blocks), compnsmg the syllabus in general pathology (basic disease processes) and organ system pathology over the 14 weeks of the semester, are as follows: WEEKl WEEK2 Introduction to Histopathology-Biopsy processing Basic Histology Contemporary Histopathology Techniques Histology Lab review of slides UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

9 WEEK3 Cell Injury, Adaptation and Inflammation-Wound healing Death WEEK4 Diseases of the Immune Animal models for System autoimmune diseases WEEKS Infectious Diseases I Infectious Diseases II --- WEEK6 Neurodegenerative diseases I Neurodegenerative - diseases II WEEK7 PRE-TEST REVIEW SESSION MID-TERM EXAMINATION WEEKS Carcinogenesis-Cancer stem Modeling cancer in mice cells-tumor microenvironment WEEK9 Pathology of Female Genital Mouse models for Breast Track /Breast cancers WEEKlO Mouse models for cancers of Pathology of Liver and Biliary the Female genital track Track WEEK 11 Pathology of Kidneys/Male Mouse models for prostate Genital Track cancer WEEK 12 Pathology of Respiratory Mouse models for lung System diseases WEEK 13 Pathology of Gastrointestinal Mouse models for Track gastrointestinal diseases WEEK14 PRE-TEST REVIEW SESSION FINAL EXAMINATION SYLLABUS Based on chapter outlines and key concepts in the textbooks proposed for adoption in the course: Damjanov L Pathology for the Health Professions. 4th Edition. Elsevier Saunders, 2012 Conn M.P. Sourcebook of Models for Biomedical Research. Humana Press, ISBN: Rubin E and Reisner HM (eds.). Essentials of Rubin 1 s Pathology. 5th Edition. Lippincott Williams & Wilkins/Welters Kluwer Health, 2009 Teicher B.A. (ed.) Tumor Models in Cancer Research. 2th Edition. Humana Press, ISBN : UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

10 INTENDED LEARNING OUTCOME Learn the language of pathology and develop an appreciation for fundamental pathologic mechanisms of disease by coming to appreciate, understand the significance of, acquire, and apply concepts of morphology, i.e. structural alterations (gross and microscopic) inherent in exemplary illustrative pathologies of diverse human cellular and organ systems. ENABLING COMPETENCIES Identify the fundamental pathologic characteristics of common diseases and conditions, based upon their etiology, pathogenesis. Describe how the altered structure (i.e. gross and microscopic pathology) of the body and its major organ systems are manifest through major diseases and conditions. Design experimental studies aiming to characterize and validate disease models ' COURSE LEARNING OBJECTIVES After completing the first part of this course, the student should be able to demonstrate knowledge of the basic histology of various organs, as well as the terminology of pathology. He should also be able to understand the processes of cellular tissues injury, developmental disorders, inflammation and repair mechanisms, immunopathology, infectious pathology. After completing the second part of this course, the student should be able to know the types and specific features of diseases especially neoplasias covered in the course that can affect the respiratory system, gastrointestinal system, hepatic and biliary tract, urinary system, and male and female reproductive systems (including breast disease) and be able to appreciate the experimental approach of disease through the development of animal models. EXEMPLARY MODULE LEARNING OBJECTIVES FROM "GENERAL ASPECTS OF PATHOLOGY" CELL PATHOLOGY UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

11 After completing this module the student should be able to: 1. Define reversible cell injury and describe the cytoplasmic changes in a cell undergoing such injury. 2. Compare and contrast reversible and irreversible cell injury. 3. Describe three types of cell adaptations. 4. Give three examples of atrophy. 5. Define and describe hypertrophy and hyperplasia and give appropriate examples of each. 6. Compare and contrast metaplasia and dysplasia and give appropriate examples of each. 7. Describe various forms of intracellular accumulation. 8. Explain the pathogenesis of fatty liver. 9. Compare two forms of cell death: apoptosis and necrosis. 10. Compare and contrast coagulative, liquefactive, and caseous necrosis. 11. Explain the difference between dystrophic and metastatic calcification. EXEMPLARY MODULE learning OBJECTIVES FROM 11 PATHOLOGY OF DISEASE WITH EMPHASIS IN NEOPLASIA" NEOPLASIA After completing this module the student should be able to: 1. Define neoplasia and its related terms: tumor, cancer, oncology. 2. Classify tumors on the basis of their histopathologic features. 3. Describe typical features of benign and malignant tumors. 4. Define metastasis and explain its pathogenesis. 5. Describe the common forms of carcinoma and sarcoma with respect to their tissues of origin and describe their benign equivalents. 6. Describe the evidence for viral carcinogenesis in humans, with special emphasis on human papillomavirus, Epstein-Barr virus, and hepatitis Band C viruses. 7. Define oncogenes and tumor suppressor genes and explain their significance in carcinogenesis GASTROINTESTINAL SYSTEM After completing this module the student should be able to: UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE SPRING 2015

12 . 1. Discuss cancer of the esophagus in terms of etiology, pathogenesis, and gross and microscopic pathology. 2. Discuss the pathogenesis of acute and chronic gastritis and peptic ulcer disease. 3. Describe the pathology of various forms of gastric cancer. 4. Describe the pathology and clinicopathologic complications of inflammatory bowel disease, comparing and contrasting Crohn disease and ulcerative colitis. 5. Describe the pathology of colon cancer, comparing the lesions of the right and left colon. 6. Design experimental studies aiming to characterize and validate gastrointestinal disease models UNIVERSITY OF SOUTH CAROLINA SC~OOL OF MEDICINE SPRING 2015