Matrix metalloproteinases

Transcription

1 Matrix metalloproteinases,, Domain 2-2. TIMPs 2-3. MMPs, 3. 4.

2 1. Collagens, proteoglycans (Extracellular matrix, ECM),,. matrixins matrix metalloproteinases (MMPs) [1, 2]. MMPs,, cytokines [3]. MMP α-macroglobulins tissue inhibitors of metalloproteinases (TIMPs). review matrixin,. MMPsprepro- pro-mmp [2]. 20 MMP Fig.1 domain motifs MMPs domaintable I. domain propeptide domain (80 ), PRCG(V/N)PD. Cyspro-MMP [4]. Catalytic domain (170 ) HEXXHXXGXXH Met-turn methionine [5]. C- hemopexin domain (210 )4 β-propeller. hemopexin domain collagens collagenases [6]. MMP-2 hemopexin domainmt1-mmp pro-mmp-2 [7]. MMP-23, hemopexin domain cysteine-rich, proline-rich IL-1 [8]. catalytic hemopexin domain proline-rich linker

3 , transmembrane domainmt- MMPs [9]. I. MMPs [2] Protein MMP Domain composition Collagenase 1 MMP-1 B Gelatinase A MMP-2 C Stromelysin 1 MMP-3 B Matrilysin MMP-7 A Collagenase 2 MMP-8 B Gelatinase B MMP-9 D Stromelysin 2 MMP-10 B Stromelysin 3 MMP-11 E Macrophage elastase MMP-12 B Collagenase 3 MMP-13 B MT1-MMP MMP-14 F MT2-MMP MMP-15 F MT3-MMP MMP-16 F MT4-MMP MMP-17 F Collagenase 4 (Xenopus) MMP-18 B (No trivial name) MMP-19 B Enamelysin MMP-20 B XMMP (Xenopus) MMP-21 G CMMP (chicken) MMP-22 B No trivial name) MMP-23 H. 1. MMP Domain [2]

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