August November 2018

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1 Activating the patient s the immune system t fight immune cancer system t Cmpany presentatin fight cancer 3Q 2018 Reprt August Nvember 2018

2 Imprtant NOTICE AND DISCLAIMER This reprt cntains certain frward-lking statements based n uncertainty, since they relate t events and depend n circumstances that will ccur in future and which, by their nature, will have an impact n the results f peratins and the financial cnditin f Targvax. Such frward-lking statements reflect the current views f Targvax and are based n the infrmatin currently available t the cmpany. Targvax cannt give any assurance as t the crrectness f such statements. There are a number f factrs that culd cause actual results and develpments t differ materially frm thse expressed r implied in these frward-lking statements. These factrs include, amng ther things, risks r uncertainties assciated with the success f future clinical trials; risks relating t persnal injury r death in cnnectin with clinical trials r fllwing cmmercializatin f the cmpany s prducts, and liability in cnnectin therewith; risks relating t the cmpany s freedm t perate (cmpetitrs patents) in respect f the prducts it develps; risks f nn-apprval f patents nt yet granted and the cmpany s ability t adequately prtect its intellectual prperty and knw-hw; risks relating t btaining regulatry apprval and ther regulatry risks relating t the develpment and future cmmercializatin f the cmpany s prducts; risks that research and develpment will nt yield new prducts that achieve cmmercial success; risks relating t the cmpany s ability t successfully cmmercialize and gain market acceptance fr Targvax s prducts; risks relating t the future develpment f the pricing envirnment and/r regulatins fr pharmaceutical prducts; risks relating t the cmpany s ability t secure additinal financing in the future, which may nt be available n favrable terms r at all; risks relating t currency fluctuatins; risks assciated with technlgical develpment, grwth management, general ecnmic and business cnditins; risks relating t the cmpany s ability t retain key persnnel; and risks relating t the impact f cmpetitin. 2

3 Status & Highlights 2. TG ne-antigen vaccine 3. ONCOS nclytic virus prgram 4. 3Q 2018 Financials 3

4 TARGOVAX AIM IS TO ACTIVATE THE PATIENT S OWN IMMUNE SYSTEM TO FIGHT CANCER Targvax fcus Immune activatrs Onclytic viruses, vaccines Immune mdulatrs Checkpint inhibitrs Surgery - Radi - Chem Immune bsters CAR-Ts, TCRs Targeted therapy TKIs, PARPs, gene therapy, etc. 4

5 Tw prgrams in clinical develpment, with an ONCOLYTIC VIRUS LEAD PRODUCT CANDIDATE ONCOS Onclytic virus TG Neantigen vaccine Lead prduct candidate Genetically armed adenvirus Alerts the immune system t recgnize cancer antigens Induces T-cells specific t the patients tumr 4 nging trials Pipeline prduct Shared neantigen, therapeutic cancer vaccine Triggers the immune system t recgnize mutant RAS cancers 1 nging trial Triggers patientspecific respnses N need fr individualizatin 5

6 3Q 2018 HIGHLIGHTS ONCOS-102 Melanma CPI refractry phase I trial: One cmplete respnse amng first six patients Innate and adaptive immune activatin in all fur evaluated patients ONCOS-102 Peritneal cancer phase I/II trial in cmbinatin w/ Imfinzi : Safety evaluatin f first dse chrt cmpleted withut any cncerns During perid ONCOS-102 Prstate cancer phase I trial in cmbinatin w/ DCVAC: First patient has been dsed Publicatins: New ONCOS-102 in viv data in the Jurnal f Medical Virlgy, shwing T-cell activatin in a mesthelima mdel Crprate develpment: Trbjørn Furuseth appinted Chief Financial Officer, with Erik Digman Wiklund transitining t the rle f Chief Business Officer Pst-perid Full data set frm the TG01 trial in resected pancreatic cancer, including encuraging disease-free survival data was annunced 6

7 Large deals in the last year shw strng INDUSTRY INTEREST IN ONCOLYTIC VIRUSES Acquirer Target Type f deal Deal value M&A Phase I/II nclytic virus USD 250m up-frnt cash M&A Phase I/II nclytic virus USD 400m up-frnt cash M&A Pre-clinical nclytic virus USD 140m up-frnt cash Up t USD 1b ttal value 7 BD partnership Pre-clinical nclytic virus USD 15m milestne payment Up t USD 1b ttal value

8 TG ne-antigen vaccine 3. ONCOS nclytic virus prgram 4. 3Q 2018 Financials

9 The RAS gene is mutated in 90% OF PANCREATIC AND 50% OF COLORECTAL CANCERS Frequency f RAS mutatins Glbal cancer incidents per 10,000 (xx) = n. f cancer patients High Med Gallbladder (180,000) Pancreas (340,000) Melanma f skin (230,000) Prstate (1,130,000) Clrectal (1,360,000) Lung (1,820,000) RAS mutatins are ncgenic and result in uncntrlled cell divisin There are n existing therapies targeting RAS mutatins Targvax TG prgram is a unique vaccine apprach fr mutant RAS cancer Lw Fernandez-Medarde; RAS in Cancer and Develpmental Diseases; Genes & Cancer. 2011;2(3)

10 TG01 IN RESECTED PANCREATIC CANCER SIGNAL OF EFFICACY SEEN IN PHASE I/II TRIAL Median verall survival (mos) (N=32) Median disease free survival (mdfs) mutras immune activatin 33.4 vs mnths reprted in the ESPAC4 trial fr gemcitabine alne (frm time f surgery) First chrt: 33.1 mnths mos (n=19) Secnd chrt: nt yet reached (n=13) 16.1 vs mnths reprted in the ESPAC4 trial fr gemcitabine alne (frm time f surgery) First chrt 13.9 mnths mdfs (n=19) Secnd chrt 19.5 mnths mdfs (n=13) 30 ut f 32 patients (94%) had RAS-specific immune activatin Dsing and safety Dsing regimen defined and TG01 is well-tlerated in cmbinatin with chemtherapy 10

11 TG01 resected pancreas cancer trial verall survival SECOND PATIENT COHORT PERFORMING BETTER 2 nd chrt; ptimized dsing regimen 77% 2-year survival rate (10/13) mos nt yet reached 9 patients alive at time f analysis 1 st chrt; full dsing regimen 68% 2-year survival rate (13/19) mos 33.1 mnths (frm surgery) ESPAC4 mos 27.6 mnths 5 patients alive at time f analysis 11

12 DISEASE FREE SURVIVAL FROM SURGERY 2nd chrt (n=13) Median DFS 19.5 mnths ESPAC4 mdfs 13.1 mnths 1st chrt (n=19) Median DFS 13.9 mnths st chrt 2 nd chrt Censred= N prgressin n latest scan cllected 12

13 OPPORTUNITIES TO DEVELOP THE TG PROGRAM Ratinale fr further develpment f TG With the emergence f immune checkpint inhibitrs, therapeutic vaccine strategies are primed fr a rebirth Clinical relevance Well-defined target Grwing interest Meaningful clinical benefit (DFS and OS) data in resected pancreatic cancer Immune activatin with generatin f mutras specific T-cells Gd safety prfile Cancer neantigens are immungenic and can drive anti-tumr immunity RAS mutatins are knwn trunk neantigens present in large patient ppulatins Cmbinatins with CPI might fully release the therapeutic ptential f neantigen vaccines Several academic grups have cntacted Targvax t run trials with TG 13

14 TG CLINICAL DEVELOPMENT STRATEGY Resected pancreatic cancer Clrectal cancer Lung cancer (NSCLC) All mutras cancers TG01 indicatin Ph I/II cmpleted Next steps being reassessed ~ incidents TG02 lead indicatin Ph I trial nging 50% mutras ~0.5m incidents TG02 ptential future indicatin 30% mutras ~0.5m incidents TG02 + TG03 lngterm ptential Up t 30% f all cancer patients 14 Surce: Glbal data, Riva et al. Pls One 2017 Estimated ttal addressable patient number with RAS mutatins in US, EU and China

15 TG DEVELOPMENT STRATEGY OVERVIEW TG pivtal develpment Future indicatin TBD Cllabrative pancreas trial Pursue pprtunities fr investigatr-led trials in pancreatic cancer CPI cmbinatin clinical trial Evaluate clinical benefit f TG vaccinatin Scin cmbinatin with PD-1/L1 blckade Pre-clinical package Generate supprting pre-clinical TG data package, incl. CPI and ONCOS cmbinatin TG01-01 phase I/II data in pancreatic cancer TG02-01 nging phase I trial in clrectal cancer TG01 histrical Hydr Pharma data 15

16 ONCOS nclytic virus prgram 4. 3Q 2018 Financials

17 ONCOS CLINICAL DEVELOPMENT STRATEGY Path-t-market Mesthelima Prf-f-cncept CPI refractry Prf-f-cncept New CPI indicatin Next generatin nclytic viruses Target launch indicatin Indicatins with n/ limited effect f CPIs Peritneal malignancies Platfrm expansin with new targets Onging Phase I/II Orphan drug status Aim t becme additin t SC 15,000 patients per year Onging melanma Phase I Cmb w/pd-1 >100,000 patients per year Onging Phase I/II in varian and clrectal Cmb w/pd-l1 >100,000 patients per year Onging pre-clinical testing Nvel targets and mde-f-actin Brad spectrum f slid tumrs 17 SOURCE: Glbal Data, EU big 5 + US

18 ONCOS CLINICAL PROGRAM OVERVIEW Mesthelima Phase I/II - randmized 30 patients Shrtest path-t-market Orphan drug designatin Cmbinatin with SC chem Randmized vs. SC Melanma Phase I up t patients PC in CPI refractry patients Cmbinatin with Keytruda Memrial Slan Kettering Cmpassinate use prgram 115 patients Phase I trial 12 patients 7 indicatins Ovarian and clrectal cancers Peritneal cancer Cmbinatin with Imfinzi Phase I/II Intraperitneal administratin up t 78 patients Cllabratin with MedImmune / AZ, CRI, & Ludwig Cmpleted trials Onging trials spnsred by Targvax Onging trials spnsred by partner Prstate cancer Phase I up t 15 patients Cmbinatin with dendritic cell vaccine (DCVAC) Cllabratin with Sti 18

19 ONCOS-102 in malignant pleural mesthelima DEVELOPMENT STRATEGY AND INDICATIVE TIMELINES Onging Phase I/II, randmized 30 patients Planned Expansin f randmized Phase II ~60 additinal patients (N=90) Future Phase III n=tbd Randmized ORR and OS data 30 patients Decide n pssible CPI cmbinatin arm EMA & FDA advisry meetings Randmized ORR and OS data 90 patients Ptentially use as basis fr a submissin fr cnditinal apprval Ptentially start Phase III OS trial fr full MAA 19

20 ONCOS KEYTRUDA MELANOMA TRIAL One cmplete respnse bserved in the first six patients 1 Safety 2 Innate immune activatin 3 Adaptive immune activatin 4 Efficacy First safety review cmpleted with n safety cncerns ONCOS-102 first time in melanma treatment Systemic increase f several prinflammatry cytkines (6/6 patients) Increase in the relative level f cyttxic CD8+ T- cells (4/4 patients) Increase in PD-1 expressin n CD8+ T-cells (4/4 patients) Cmplete respnse in ne ut f six patients Expected <5% CR in this CPI refractry ppulatin* 20 *SOURCE: Checkmate Pharmaceutical, press release 17 April 2018

21 MELANOMA COMPLETE RESPONSE CASE EXAMPLE Received 3 injectins f ONCOS-102 and 2 Keytruda infusins Baseline Day 22 Day Tw immuntherapies received prir t study (Yervy and Keytruda)

22 3Q 2018 Financials

23 TARGOVAX HAS A SOUND FINANCIAL POSITION with cash t cmplete the planned clinical prgram int 2020 Operatins The share Cash end f 3Q - Sep 30 th NOK millin -27 NOK millin 21 USD millin Net cash flw - ttal 3Q 112 NOK millin -3 USD millin Annual run rate - last fur quarters 14 USD millin Market Cap - at share price NOK ~9 470 NOK millin 2.5 NOK millin 57 USD millin Daily turnver - rlling 6 mnth avg. Analyst cverage 0.3 USD millin DNB, ABG Sundal Cllier, Arctic, Redeye, Edisn 0.5 % f share capital 23

24 TARGOVAX IS LISTED ON THE OSLO STOCK EXCHANGE and included in the OSEBX index as f December 2017 TRVX share turnver (% f share capital, rlling 12 mnth) USD ~57 m market cap USD 0,3m avg. daily turnver in last 6 mnths USD 13m ttal turnver in 3Q 150k shares avg. daily vlume in 3Q ~ 4,000 wners 52.6m shares* (57.4 fully diluted) 24 * Up until 30 th Sep

25 R&D PIPELINE OVERVIEW AND MILESTONES Platfrm Prduct candidate Preclinical Phase I Phase II Phase III Last event Next expected event Mesthelima Cmb. w/ pemetrexed/cisplatin 1 Phase Ib safety lead-in chrt, incl. immune activatin and ORR data (6 pts) 1H 2020 Randmized ORR data 30 pts ONCOS nclytic adenvirus ONCOS-102 Melanma Cmb. w/keytruda Peritneal cancers 2,3 Cllab: Ludwig, CRI & AZ Cmb. w/imfinzi Prstate 3 Cllab: Sti Cmb. w/dcvac ORR and immune activatin (6 pts), 1/6 CR First dse escalatin chrt safety review (4 pts) First patient dsed 1H 2019 ORR and immune data first chrt Update by cllabratr, expected 2019 Update by cllabratr, expected 2019 Next-gen ONCOS 3 viruses undisclsed Virus cnstruct clning and in vitr validatin 2H 2019 Target disclsure and in viv data TG neantigen cancer vaccine TG01 TG02 TG02 Pancreatic cancer Cmb. w/gemcitabine Clrectal cancer Prf-f-mechanism Cmb. w/keytruda CPI synergy TG + PD-1 mos 33.4 mnths Demnstrated mutant RASspecific immune activatin First safety review, incl. immune activatin data (3 pts) TBD 1H 2019 Immune activatin and mechanistic data (mn) 1H 2019 TG02 + in viv data 1 Current standard f care chemtherapy fr patients with unresectable malignant pleural mesthelima 2 Patients with advanced peritneal disease, wh have failed prir standard chemtherapy and have histlgically cnfirmed platinum-resistant r refractry epithelial varian r clrectal cancer 3 Trials spnsred by cllabratrs Onging cllabratr spnsred trials 25 25

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