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1 Note: Page numbers of article titles are in boldface type. A Ablative therapy, nonsurgical, for pulmonary metastases of soft tissue sarcoma, Adipocytic tumors, atypical lipomatous tumor vs. well-differentiated liposarcoma, Adjuvant therapy, after pulmonary metastasectomy, chemotherapy, radiation, 277 chemotherapy for soft tissue sarcomas, histology-specific trials of, bone sarcoma, gastrointestinal stromal tumors, 251 leiomyosarcoma, 250 liposarcoma, 250 synovial sarcoma, neoadjuvant, systemic, chemotherapy plus radiation for extremity and truncal soft tissue sarcomas, 229 for primary resectable gastrointestinal stromal tumors, preoperative vs. postoperative radiation for extremity soft tissue sarcomas, radiation for retroperitoneal sarcoma, Adjuvants, use in vaccines sarcomas, clinical data for, Adoptive immunotherapy, for sarcomas, clinical data for, Adriamycin, for adjuvant chemotherapy of soft tissue sarcomas, ifosfamide and, meta-analysis of trials of, 248 Amputation, for soft tissue sarcomas of extremities, 210 Atypical lipomatous tumor, vs. well-differentiated liposarcomas, B Biopsy, diagnostic, for soft tissue sarcomas, 191 Bone sarcomas, histology-specific adjuvant chemotherapy trials for, Brachytherapy, for extremity and truncal soft tissue sarcomas, for soft tissue sarcomas of extremities, C Chemotherapy, adjuvant, after pulmonary metastasectomy, adjuvant, for soft tissue sarcomas, histology-specific trials of, bone sarcoma, gastrointestinal stromal tumors, 251 leiomyosarcoma, 250 liposarcoma, 250 Surg Oncol Clin N Am 21 (2012) doi: /s (12) surgonc.theclinics.com /12/$ see front matter ª 2012 Elsevier Inc. All rights reserved.
2 358 Chemotherapy (continued) synovial sarcoma, neoadjuvant, systemic, meta-analysis of trials, 248 prospective studies of Adriamycin, prospective studies of Adriamycin and ifosfamide, for soft tissue sarcomas of extremities, neoadjuvant doxorubicin-based, plus radiation for extremity and truncal soft tissue sarcomas, systemic, for retroperitoneal sarcoma, Computed tomography (CT), prior to pulmonary metastasectomy for soft tissue sarcomas, 271 D Death, due to soft tissue sarcomas of extremities, risk factors for, 202 Doxorubicin, neoadjuvant, plus radiation for extremity and truncal soft tissue sarcomas, E Epidemiology, of soft tissue sarcomas, External beam radiation therapy. See also Radiation therapy. treatment planning for extremity and truncal soft tissue sarcomas, Extremities, soft tissue sarcomas of, , , isolated regional therapy for advanced, hyperthermic isolated limb perfusion technique, indications for, 288 isolated limb infusion technique, 289 limb preservation with, locoregional recurrence after, 296 outcome after, palliative, toxicity, limb salvage and role of amputation, amputation, 210 chemotherapy, isolated limb infusion, 208 isolated limb perfusion, limb salvage surgery, radiation therapy, reconstruction, regional hyperthermia, risk factors for recurrence and death, 202 radiation therapy for truncal and, , brachytherapy, , wound complications and, 230 combining adjuvant chemotherapy with adjuvant, 229 for local recurrence, for locally advanced soft tissue sarcoma, 232 functional outcome, 231 intensity-modulated photon, neoadjuvant doxorubicin-based chemotherapy plus,
3 359 of the hand and foot, 229 patient selection for surgical resection combined with, preoperative (neoadjuvant) vs. postoperative (adjuvant), preoperative vs. postoperative, preoperative, and wound complications, 230 proton beam, strategies to reduce wound morbidity, treatment planning for external beam, treatment volumes and doses, wound healing after surgery and, F Familial gastrointestinal stromal tumors, 310 Foot, radiation therapy for soft tissue sarcomas of, 229 Functional outcome, after radiation therapy for extremity and truncal soft tissue sarcomas, 231 G Gastrointestinal stromal tumors, clinical presentation and diagnosis, epidemiology, 301 familial, 310 future strategies, histology-specific adjuvant chemotherapy trials for, 251 pathologic findings, pediatric, 310 risk stratification, treatment, of imatinib-resistant disease, primary resectable disease, primary unresectable disease, recurrent and metastatic disease, Genetic markers, of soft tissue sarcomas, Grade, as prognostic variable in retroperitoneal sarcoma, Grading systems, for soft tissue sarcomas, H Hand, radiation therapy for soft tissue sarcomas of, 229 Hyperthermic isolated limb perfusion, for soft tissue sarcomas of extremities, , indications for, 288 limb preservation with, outcome after, 292 regional toxicity after, 291 systemic toxicity after, technique, I Ifosfamide, Adriamycin and, for adjuvant chemotherapy of soft tissue sarcomas, for adjuvant chemotherapy of soft tissue sarcomas, meta-analysis of trials of, 248 Imaging, prior to pulmonary metastasectomy for soft tissue sarcomas,
4 360 Imatinib, treatment of gastrointestinal stromal tumors resistant to, Immunoediting, evidence for, and immune response in sarcomas, Immunotherapy, sarcomas and the immune system, clinical data for immunotherapy, adoptive, role of other immune-associated molecules, 350 use of adjuvants, vaccines, historical perspective, immunoediting, evidence for, Incidence, of soft tissue sarcomas, Intensity-modulated photon radiation therapy. See also Radiation therapy. for extremity and truncal soft tissue sarcomas, Isolated limb infusion, for soft tissue sarcomas of extremities, 208 for advanced cases, indications, 288 limb preservation with, 293 outcome after, regional toxicity after, systemic toxicity after, technique, 289 Isolated limb perfusion, for soft tissue sarcomas of extremities, hyperthermic, for advanced cases, indications for, 288 limb preservation with, outcome after, 292 regional toxicity after, 291 systemic toxicity after, technique, Isolated regional therapy, for advanced extremity soft tissue sarcomas, hyperthermic isolated limb perfusion technique, indications for, 288 isolated limb infusion technique, 289 limb preservation with, locoregional recurrence after, 296 outcome after, palliative, toxicity, L Leiomyosarcoma, histology-specific adjuvant chemotherapy trials for, 250 Limb preservation, for advanced extremity soft tissue sarcomas, with hyperthermic isolated limb perfusion with isolated limb infusion for advanced extremity soft tissue sarcomas, 294 Limb-salvage surgery, of soft tissue sarcomas of extremities, Liposarcoma, histology-specific adjuvant chemotherapy trials for, 250 Liposarcomas, well-differentiated, clinical evaluation of, 335 pathologic classification of adipocytic tumors, recurrence,
5 361 role of radiation therapy, 336 surgical resection of, Local recurrence. See Recurrence. M Margin status, and local recurrence and survival with soft tissue sarcoma, appropriate resection margins, 256 management of positive margins, pathologic assessment of, Metastasectomy, pulmonary, for soft tissue sarcoma, adjuvant therapy after, extent of resection, imaging evaluation, long-term survival following, 277 nonsurgical ablative therapy compared with, patient selection for, recurrence and repeated, surgical approach to, Metastases, of gastrointestinal stromal tumors, N Neoadjuvant therapy, chemotherapy for soft tissue sarcomas, doxorubicin chemotherapy plus radiation for extremity and truncal soft tissue sarcomas, preoperative vs. postoperative radiation for extremity soft tissue sarcomas, O Outcome, functional, after radiation therapy for extremity and truncal soft tissue sarcomas, 231 of isolated regional therapy for advanced soft tissue sarcomas of extremities, Outcomes, of retroperitoneal sarcomas, clinical measures of, local recurrence, overall survival, 319 prognostic variables for, grade, primary vs. recurrent tumor, resection status, 320 strategies for improving, adjuvant radiation therapy, centralized multidisciplinary care, 328 surgical resection, systemic chemotherapy, P Palliative therapy, isolated regional, for advanced extremity soft tissue sarcomas, Pediatrics, gastrointestinal stromal tumors, 310
6 362 Pneumonectomy, in pulmonary metastasectomy, 275 Positron emission tomography, prior to pulmonary metastasectomy for soft tissue sarcomas, Prognostic variables, and staging for soft tissue sarcomas, for retroperitoneal sarcoma outcome, grade, primary vs. recurrent tumor, resection status, 320 Proton beam radiation therapy. See also Radiation therapy. for extremity and truncal soft tissue sarcomas, Pulmonary metastasectomy, for soft tissue sarcoma, adjuvant therapy after, extent of resection, extended resection, 275 pneumonectomy, 275 thoracic lymph node dissection, imaging evaluation, long-term survival following, 277 nonsurgical ablative therapy compared with, patient selection for, recurrence and repeated, surgical approach to, median sternotomy, 273 posterolateral thoracotomy, 273 transsternal thoracotomy, 273 video-assisted thoracoscopic surgery, R Radiation therapy, adjuvant, after pulmonary metastasectomy, 277 adjuvant, of retroperitoneal sarcoma, for extremity and truncal soft tissue sarcomas, , brachytherapy, , wound complications and, 230 combining adjuvant chemotherapy with adjuvant, 229 for local recurrence, for locally advanced soft tissue sarcoma, 232 functional outcome, 231 intensity-modulated photon, neoadjuvant doxorubicin-based chemotherapy plus, of the hand and foot, 229 patient selection for surgical resection combined with, preoperative (neoadjuvant) vs. postoperative (adjuvant), preoperative vs. postoperative, preoperative, and wound complications, 230 proton beam, strategies to reduce wound morbidity, treatment planning for external beam, treatment volumes and doses, wound healing after surgery and, for retroperitoneal sarcomas, role in well-differentiated liposarcoma, 336
7 363 Radiofrequency ablation, for pulmonary metastases of soft tissue sarcoma, Recurrence, local, after radiation therapy for extremity and truncal soft tissue sarcomas, margin status and, with soft tissue sarcoma, appropriate resection margins, 256 management of positive margins, pathologic assessment of, of retroperitoneal sarcoma, locoregional, after isolated regional therapy for advanced soft tissue sarcomas of extremities, 296 of gastrointestinal stromal tumors, of pulmonary metastases, repeated pulmonary metastasectomy for, of soft tissue sarcomas of extremities, risk factors for, 202 of well-differentiated liposarcoma, Regional hyperthermia. See also Hyperthermic isolated limb perfusion. for soft tissue sarcomas of extremities, Retroperitoneal sarcomas, clinical outcome measures, local recurrence, overall survival, 319 improving outcomes of, adjuvant radiation therapy, centralized multidisciplinary care, 328 surgical resection, systemic chemotherapy, prognostic variables for outcome, grade, primary vs. recurrent tumor, radiation therapy for, S Sarcomas. See Soft tissue sarcomas. Soft tissue sarcomas, adjuvant chemotherapy, histology-specific trials of, bone sarcoma, gastrointestinal stromal tumors, 251 leiomyosarcoma, 250 liposarcoma, 250 synovial sarcoma, neoadjuvant, systemic, and the immune system, clinical data for immunotherapy, adoptive, preclinical data, role of other immune-associated molecules, 350 use of adjuvants, vaccines, historical perspective, immunoediting, evidence for,
8 364 Soft tissue (continued) gastrointestinal stromal tumors, clinical presentation and diagnosis, epidemiology, 301 familial, 310 future strategies, pathologic findings, pediatric, 310 risk stratification, treatment, of imatinib-resistant disease, primary resectable disease, primary unresectable disease, recurrent and metastatic disease, liposarcoma, well-differentiated, clinical evaluation of, 335 pathologic classification of adipocytic tumors, recurrence, role of radiation therapy, 336 surgical resection of, margin status, local recurrence, and survival, appropriate resection margins, 256 management of positive margins, pathologic assessment of, of extremities, , isolated regional therapy for advanced, hyperthermic isolated limb perfusion technique, indications for, 288 isolated limb infusion technique, 289 limb preservation with, locoregional recurrence after, 296 outcome after, palliative, toxicity, limb salvage and role of amputation, amputation, 210 chemotherapy, isolated limb infusion, 208 isolated limb perfusion, limb salvage surgery, radiation therapy, reconstruction, regional hyperthermia, risk factors for recurrence and death, 202 prognostic factors and staging, additional factors, clinical presentation and staging, diagnostic biopsy, 191 future of, genetics, grading systems,
9 365 incidence and epidemiology, staging systems, pulmonary metastasectomy for, adjuvant therapy after, extent of resection, imaging evaluation, long-term survival following, 277 nonsurgical ablative therapy compared with, patient selection for, recurrence and repeated, surgical approach to, radiation therapy, for extremity and truncal, for retroperitoneal, overview, retroperitoneal, clinical outcome measures, local recurrence, overall survival, 319 improving outcomes of, adjuvant radiation therapy, centralized multidisciplinary care, 328 surgical resection, systemic chemotherapy, prognostic variables for outcome, grade, primary vs. recurrent tumor, Staging, of soft tissue sarcomas, clinical presentation and, systems for, Stereotactic body radiotherapy, for pulmonary metastases of soft tissue sarcoma, Surgical resection, combined with radiation therapy for truncal and extremity soft tissue sarcomas, for primary resectable gastrointestinal stromal tumors, limb-salvage surgery of soft tissue sarcomas of extremities, margin status, local recurrence, and survival, appropriate resection margins, 256 management of positive margins, pathologic assessment of, of retroperitoneal sarcoma, of well-differentiated liposarcoma, pulmonary metastasectomy for soft tissue sarcomas, Survival, long-term, following pulmonary metastasectomy, 277 margin status and, in soft tissue sarcomas, overall, in retroperitoneal sarcoma, 319 Synovial sarcoma, histology-specific adjuvant chemotherapy trials for, T Thoracic lymph node dissection, in pulmonary metastasectomy, Toxicity, of isolated regional therapy for advanced soft tissue sarcomas of extremities, regional,
10 366 Toxicity (continued ) systemic, Truncal soft tissue sarcomas, radiation therapy for extremity and, Tumor-associated antigens, in immunotherapy of sarcomas, V Vaccines, for sarcomas, clinical data for, Video-assisted thoracoscopic surgery, for pulmonary metastasectomy, W Well-differentiated liposarcomas. See Liposarcomas. Wound healing, after radiation therapy for extremity and truncal soft tissue sarcomas, brachytherapy and wound complications, 230 complications after preoperative, 230 strategies to reduce wound morbidity,
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