Understanding Your Blood Work Results
|
|
- Lora Rich
- 6 years ago
- Views:
Transcription
1 Understanding Your Blood Work Results Carlos Besses, MD, hd Hematology Department Hospital del Mar - IMIM, Barcelona
2 Carlos Besses Disclosures Novartis Honorarium Speaker Shire Honorarium Speaker Galena Honorarium Advisory Board
3 Abnormal blood results Diagnostic process History taking hysical examination Additional tests Genetic tests Bone marrow examination
4 Blood Results Leading to Suspicion of MN Thrombocytosis ( platelets) Erythrocytosis ( red blood cells) V Leukocytosis ( white blood cells) Anemia ( red blood cells) ET Thrombocytopenia ( platelets) Any combination of the above MF
5 Work-up for a atient with Thrombocytosis latalet count 450x10 9 /L Secondary thrombocytosis ersistent unexplained thrombocytosis History taking hysical examination Additional tests Iron deficiency Infection Inflammation Surgery Cancer Splenectomy Any relative with MN or excess of blood cells? Microvascular symptoms Usually normal Genetic tests Bone marrow examination
6 Normal
7 ET
8 Workflow for Molecular Diagnosis of ET ET Suspicion JAK2 V617F ositive 50-60% Negative CALR ositive 15-35% Negative ML ositive 3-5% Essential Thrombocythemia Negative BCR-ABL1 Triple-Negative 5-25% Negative ositive CML
9 ET Clinical Case, bone marrow biopsy
10 ET
11 A B C Megakaryocyte nuclei: A. Hyperlobulation: staghorn-like B. Hypolobulation: bulbous/cloud-like C. Hyperchromatic
12 Work-up for a atient with Erytrocytosis Increased Hct/Hb History taking hysical examination Additional tests Chronic lung disease Smoking Renal disease Tumors Androgen/Epo use Sleep apnea Chest X Ray Abdominal ultrasound Oxygen saturation Carboxy hemoglobin Splenomegaly Red cell mass JAK2V617F Erythropoietin level Bone marrow examination Thrombocitosis and/or Leukocytosis
13 Normal
14 V
15 EO TO Type I cytokine receptors EOR TOR G-CSF CYTOLASM JAK2 JAK2 NUCLEUS
16 EO TO Type I cytokine receptors EOR TOR G-CSF CYTOLASM JAK2 JAK2 STAT STAT NUCLEUS Gene transcription
17 EO TO Type I cytokine receptors EOR TOR G-CSF CYTOLASM JAK2 JAK2 G>T GTC TTC Val (V) he (F) STAT STAT NUCLEUS Gene transcription
18 V
19 Work-up for a atient with Leukocytosis Increased leukocyte count History taking Secondary leukocytosis hysical examination Splenomegaly and/or lymphadenopathy Additional tests Blood film Infections Acute inflammation Corticosteroids Smoking Myeloid cells Chromosome and/or genetic studies Cell flow cytometry CT scans ET, MRI Lymphoid cells
20 What are the Cells Involved in Myeloid Diseases?
21 CLL V
22 CML
23 Work-up for a atient with Suspicion of Myelofibrosis Anemia +/- Other cytopenia +/- WBC/platelets plus Splenomegaly Genetic test eripheral blood Bone marrow biopsy +/- Cytogenetic study Mandatory JAK2V617F, CALR, ML +/- BCR-ABL1 Optional ASXL1, SRSF2, EZH2, IDH1/2 Blood film +/- Cytogenetic study Staining for: Hematoxylin-eosin Reticulin Collagen
24 MF
25 Myelofibrosis: an heterogeneous disease ET
26 Staging of Bone Marrow Fibrosis Severity in Myelofibrosis Bone Marrow Fibrosis Grading According to European Myelofibrosis Network (EUMNET) Consensus Criteria MF 0 MF 1 MF 2 MF 3 Scattered linear reticulin, no intersections 1-3 Loose network of reticulin with many intersections 1-3 Diffuse, dense increase in reticulin with extensive intersections and occasional collagen foci 1-3 Diffuse and dense increase in reticulin with extensive intersections; presence of coarse collagen bundles, often with significant osteosclerosis 1-3 With kind permission from Springer Science +Business Media: Annals of Hematology. Ref. 2, Fig Thiele J, et al. Haematologica. 2005;90: Thiele J, Kvasnicka HM. Ann Hematol. 2006;85: Michiels JJ, Thiele J. Int J Hematol. 2002;76:133
27 Reticulin fibrosis MF0 MF1 MF2 MF3
28 MF
29 WHO-Classification Thiele et al, Blood 2011;117(21):
30 A B C Megakaryocyte nuclei: A. Hyperlobulation: staghorn-like B. Hypolobulation: bulbous/cloud-like C. Hyperchromatic
31 Survival and Disease Complications in ET vs. Early/refibrotic MF Outcome ET 15-Year Cumulative Incidence (%) Early/refibrotic MF 15-Year Cumulative Incidence (%) Survival 75% 44% Leukemic transformation 2% 12% Transformation to overt myelofibrosis 9% 17% Thrombosis 22% 25% Results from 1104 patients; 891 (81%) True ET; 180 (16%) early/prefibrotic MF; 33 (3%) not evaluable Median follow-up: 6.2 years for ET; 7 years for early/prefibrotic MF Barbui et al, J Clin Oncol 2011;29(23):
32 V Suspicion ET Suspicion MF Suspicion Discard BCR-ABL JAK2V617F JAK2V617F JAK2V617F ositive Negative ositive Negative ositive Negative JAK2 exon 12 CALR CALR ositive Negative ositive Negative ositive Negative ML ML ositive Negative ositive Negative olycythemia Vera Essential Thrombocythemia rimary Myelofibrosis
33 Conclusions 1. Blood work results are important information but the diagnosis relies on the whole picture 2. Genetic studies & Bone marrow examination are essential components of the diagnosis 3. Common-sense and step-based tests are the best way to reach a well-grounded diagnosis lease, trust in your doctor!
34 Thank you for your attention
Disclosure BCR/ABL1-Negative Classical Myeloproliferative Neoplasms
Disclosure BCR/ABL1-Negative Classical Myeloproliferative Neoplasms Sonam Prakash declares affiliation with Incyte Corporation: Advisor for Hematopathology Publications Steering Committee Sonam Prakash,
More informationWHO Update to Myeloproliferative Neoplasms
WHO Update to Myeloproliferative Neoplasms Archana M Agarwal, MD, Associate Professor of Pathology University of Utah Department of Pathology/ARUP Laboratories Myeloproliferative Neoplasms The categories
More informationOpportunities for Optimal Testing in the Myeloproliferative Neoplasms. Curtis A. Hanson, MD
Opportunities for Optimal Testing in the Myeloproliferative Neoplasms Curtis A. Hanson, MD 2013 MFMER slide-1 DISCLOSURES: Relevant Financial Relationship(s) None Off Label Usage None 2013 MFMER slide-2
More informationMPN What's new in the morphological classification, grading of fibrosis and the impact of novel drugs
MPN What's new in the morphological classification, grading of fibrosis and the impact of novel drugs Hans Michael Kvasnicka University of Frankfurt, Germany hans-michael.kvasnicka@kgu.de Disclosure of
More informationMyeloproliferative Disorders in the Elderly: Clinical Presentation and Role of Bone Marrow Examination
Myeloproliferative Disorders in the Elderly: Clinical Presentation and Role of Bone Marrow Examination Arati V. Rao, M.D. Division of Medical Oncology and Geriatrics Duke University Medical Center Durham
More informationDisclosures. Myeloproliferative Neoplasms: A Case-Based Approach. Objectives. Myeloproliferative Neoplasms. Myeloproliferative Neoplasms
Myeloproliferative Neoplasms: A Case-Based Approach Disclosures No conflicts of interests regarding the topic being presented Adam M. Miller, MD PGY-4 Resident Physician Department of Pathology and Laboratory
More informationNew WHO Classification of Myeloproliferative Neoplasms
New WHO Classification of Myeloproliferative Neoplasms Hans Michael Kvasnicka Senckenberg Institute of Pathology, University of Frankfurt, Germany hans-michael.kvasnicka@kgu.de Principles and rationale
More informationBone marrow histopathology in Ph - CMPDs. - the new WHO classification - Juergen Thiele Cologne, Germany
Bone marrow histopathology in Ph - CMPDs - the new WHO classification - Juergen Thiele Cologne, Germany Current issues in MPNs concerning morphology 1.Prodromal stages of disease 2.Impact of histopathology
More informationDisclosures for Ayalew Tefferi
Disclosures for Ayalew Tefferi Principal investigator role Employee Consultant Major Stockholder Speakers Bureau Scientific Advisory Board Janssen, Geron, Celgene, Sanofi-Aventis, Gilead Sciences, Incyte
More informationPolycthemia Vera (Rubra)
Polycthemia Vera (Rubra) Polycthemia Vera (Rubra) Increased red cells Clonal Myeloid lineages also increased 2-13 cases per million Mean age: 60 years Sites of Involvement Bone marrow Peripheral blood
More informationManaging ET in Tiziano Barbui MD
Managing ET in 2019 Tiziano Barbui MD (tbarbui@asst-pg23.it) Hematology and Foundation for Clinical Research, Hospital Papa Giovanni XXIII Bergamo, Italy Managing ET in 2019 Establish diagnosis Risk Stratification
More informationChronic Idiopathic Myelofibrosis (CIMF)
Chronic Idiopathic Myelofibrosis (CIMF) CIMF Synonyms Agnogenic myeloid metaplasia Myelosclerosis with myeloid metaplasia Chronic granulocytic-megakaryocytic myelosis CIMF Megakaryocytic proliferation
More informationThe prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin fibrosis in essential thrombocythemia
Received: 3 February 2017 Revised: 13 February 2017 Accepted: 14 February 2017 DOI: 10.1002/ajh.24689 RESEARCH ARTICLE The prognostic relevance of serum lactate dehydrogenase and mild bone marrow reticulin
More informationMDS/MPN MPN MDS. Discolosures. Advances in the Diagnosis of Myeloproliferative Neoplasms. Myeloproliferative neoplasms
Discolosures Advances in the Diagnosis of Myeloproliferative Neoplasms Consulting income from Promedior, Inc. Robert P Hasserjian, MD Associate Professor Massachusetts General Hospital and Harvard Medical
More informationCME Information: Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification, and management
AJH CME Information: Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification, and management Author: Ayalew Tefferi If you wish to receive credit for this activity,
More information74y old Female with chronic elevation of Platelet count. August 18, 2005 Faizi Ali, MD Hematopathology Fellow
74y old Female with chronic elevation of Platelet count August 18, 2005 Faizi Ali, MD Hematopathology Fellow Clinical History Patient is a 74y old otherwise healthy Caucasian female with no major complaint
More informationDisclosures. I do not have anything to disclose. Shared Features of MPNs. Overview. Diagnosis and Molecular Monitoring in the
Myeloproliferative Neoplasms: Diagnosis and Molecular Monitoring in the Target Therapy Era C. Cameron Yin, M.D., Ph.D. Department of Hematopathology UT MD Anderson Cancer Center Disclosures I do not have
More information[COMPREHENSIVE GENETIC ASSAY PANEL ON
2014 SN GENELAB AND RESEARCH CENTER DR. SALIL VANIAWALA, PH.D [COMPREHENSIVE GENETIC ASSAY PANEL ON MYELOPROLIFERATIVE NEOPLASMS] SN Genelab presents one of the most comprehensive genetic assay panel for
More informationDisclosures for Ayalew Tefferi
Disclosures for Ayalew Tefferi Principal investigator role Employee Consultant Major Stockholder Speakers Bureau Scientific Advisory Board Janssen, Geron, Celgene, Sanofi-Aventis, Gilead Sciences, Incyte
More informationHistological evaluation of myeloproliferative neoplasms
Journal of clinical and experimental hematopathology Vol. 58 No.2, 45-50, 2018 JC lin EH xp ematopathol Review Article Histological evaluation of myeloproliferative neoplasms Hideyo Fujiwara In 2017, the
More informationWHO 2016/17 update on Myeloproliferative Neoplasms. Anna Ruskova Auckland City Hospital New Zealand
WHO 2016/17 update on Myeloproliferative Neoplasms Anna Ruskova Auckland City Hospital New Zealand BLOOD, 19 MAY 2016 x VOLUME 127, NUMBER 20 2 2016/17 Classification of Myeloproliferative Neoplasms Chronic
More informationIntro alla patologia. Giovanni Barosi. Fondazione IRCCS Policlinico San Matteo Pavia
Settima Giornata Fiorentina dedicata ai pazienti con malattie mieloproliferative croniche Sabato 13 Maggio 2017 CRIMM Centro di Ricerca e Innovazione per le Malattie Mieloproliferative AOU Careggi Intro
More informationMyelodysplastic syndrome (MDS) & Myeloproliferative neoplasms
Myelodysplastic syndrome (MDS) & Myeloproliferative neoplasms Myelodysplastic syndrome (MDS) A multipotent stem cell that can differentiate into any of the myeloid lineage cells (RBCs, granulocytes, megakaryocytes)
More informationEmerging diagnostic and risk stratification criteria
PV STATE OF MIND Polycythemia vera: Emerging diagnostic and risk stratification criteria Rami S. Komrokji, MD Moffitt Cancer Center, Tampa, Florida Disclosure These slides were developed by Incyte Corporation
More informationMyeloproliferative Neoplasms: Diagnosis and Molecular Monitoring in the Era of Target Therapy
Myeloproliferative Neoplasms: Diagnosis and Molecular Monitoring in the Era of Target Therapy C. Cameron Yin, M.D., Ph.D. Department of Hematopathology UT MD Anderson Cancer Center Disclosures I do not
More informationPolycythemia Vera and Essential Thombocythemia A Single Institution Experience
INDIAN JOURNAL OF MEDICAL & PAEDIATRIC ONCOLOGY Vol. 29 No 4, 2008 7 Original Article-I Polycythemia Vera and Essential Thombocythemia A Single Institution Experience CECIL ROSS, NAVYA, VANAMALA AND KARUNA
More informationWelcome to Master Class for Oncologists. Session 3: 9:15 AM - 10:00 AM
Welcome to Master Class for Oncologists Session 3: 9:15 AM - 10:00 AM Miami, FL December 18, 2009 Myeloproliferative Neoplasms: Bringing Order to Complexity and Achieving Optimal Outcomes Speaker: Andrew
More informationLeukemia and subsequent solid tumors among patients with myeloproliferative neoplasms
Leukemia and subsequent solid tumors among patients with myeloproliferative neoplasms Tiziano Barbui (tbarbui@asst-pg23.it Hematology and Research Foundation,Ospedale Papa Giovanni XXIII, Bergamo Italy
More informationJAK inhibitors in Phmyeloproliferative
Disclosures for A Pardanani Research Support/P.I. Employee Consultant Major Stockholder Speakers Bureau Scientific Advisory Board TargeGen, Cytopia/YM BioSciences, PharmaMar None None None None None Presentation
More informationThe myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations
2017 USCAP, Inc All rights reserved 0893-3952/17 $32.00 169 The myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations Umberto Gianelli 1, Daniele Cattaneo 2, Anna Bossi
More informationMyeloproliferative Neoplasms and Treatment Overview
Myeloproliferative Neoplasms and Treatment Overview George Nesr Clinical Research Fellow in Haematology Haematology Department Imperial College Healthcare NHS Trust Overview Historical Background Pathogenesis
More informationHematology Unit Lab 2 Review Material
Objectives Hematology Unit Lab 2 Review Material - 2018 Laboratory Instructors: 1. Assist students during lab session Students: 1. Review the introductory material 2. Study the case histories provided
More informationMyelodysplastic Syndromes Myeloproliferative Disorders
Myelodysplastic Syndromes Myeloproliferative Disorders Myelodysplastic Syndromes characterized by maturation defects that are associated with ineffective hematopoiesis and a high risk of transformation
More informationBiology Diagnosis and Classification of MPD
Biology Diagnosis and Classification of MPD Jan Jacques Michiels 1,7, Hendrik De Raeve 2, Konnie Hebeda 3, King H. Lam 4, Freek Bot 5, Zwi Berneman 1, Wilfried Schroyens 1 Departments of Hematology 1 and
More informationJAK2 Inhibitors for Myeloproliferative Diseases
JAK2 Inhibitors for Myeloproliferative Diseases Srdan (Serge) Verstovsek M.D., Ph.D. Associate Professor Department of Leukemia University of Texas MD Anderson Cancer Center Houston, Texas, USA Myeloproliferative
More informationReproducibility of Histologic Classification in Nonfibrotic Myeloproliferative Neoplasia
Hematopathology / Morphologic Features in MPN Reproducibility of Histologic Classification in Nonfibrotic Myeloproliferative Neoplasia Suzanne M. Koopmans, MD, 1 Freek J. Bot, MD, PhD, 1,2 King H. Lam,
More informationMYELOPROLIFERATIVE NEOPLASMS
9 : 2 MYELOPROLIFERATIVE NEOPLASMS Introduction William Dameshek in 1951 introduced the term Myeloproliferative disorders (MPD). This included polycythemia vera (PV), essential thrombocythemia (ET), primary
More informationCase Workshop of Society for Hematopathology and European Association for Haematopathology
Case 148 2007 Workshop of Society for Hematopathology and European Association for Haematopathology Robert P Hasserjian Department of Pathology Massachusetts General Hospital Boston, MA Clinical history
More informationPolycythemia Vera and other Myeloproliferative Neoplasms. A.Mousavi
Polycythemia Vera and other Myeloproliferative Neoplasms A.Mousavi Chronic MPNs Multipotent hematopoietic progenitor cell is origin. Overproduction of one or more formed element of blood cells without
More informationMolecular aberrations in MPN. and use in the clinic. Timothy Devos MD PhD
Molecular aberrations in MPN and use in the clinic Timothy Devos MD PhD MB&C2017 24-3-2017 Introduction 1951: William Dameshek MPD MPN = clonal, hematopoietic stem cell disorders, proliferation in BM of
More informationTechnical Bulletin No. 100
CPAL Central Pennsylvania Alliance Laboratory Technical Bulletin No. 100 August 2, 2012 JAK2 AND MPL 515 MUTATIONAL ANALYSIS Contact: Dr. Jeffrey Wisotzkey, 717-851-1422 Technical Director, CPAL Jill A.
More informationAbstracting Hematopoietic Neoplasms
CASE 1: LYMPHOMA PHYSICAL EXAMINATION 43yo male with a history of lower gastrointestinal bleeding and melena undergoing colonoscopy and biopsy to rule out neoplasm versus inflammation. Patient had no other
More informationMyeloproliferative Neoplasms
Myeloproliferative Neoplasms (MPN and MDS/MPN) Attilio Orazi, MD, FRCPath Weill Cornell Medical College/ NY Presbyterian Hospital, New York, NY USA EAHP EDUCATIONAL SESSION: Updated WHO classification
More informationShould Intermediate-I risk PMF be transplanted immediately or later? Position: Later
Should Intermediate-I risk PMF be transplanted immediately or later? Position: Later Vikas Gupta, MD, FRCP, FRCPath Associate Professor Department of Medicine Leukemia/BMT Programs Princess Margaret Cancer
More informationUpdate on Myelodysplastic Syndromes and Myeloproliferative Neoplasms. Kaaren Reichard Mayo Clinic Rochester
Update on Myelodysplastic Syndromes and Myeloproliferative Neoplasms Kaaren Reichard Mayo Clinic Rochester Reichard.kaaren@mayo.edu Nothing to disclose Conflict of Interest Learning Objectives Present
More informationMyeloproliferative Disorders: Diagnostic Enigmas, Therapeutic Dilemmas. James J. Stark, MD, FACP
Myeloproliferative Disorders: Diagnostic Enigmas, Therapeutic Dilemmas James J. Stark, MD, FACP Medical Director, Cancer Program and Palliative Care Maryview Medical Center Professor of Medicine, EVMS
More informationMyeloproliferative Disorders - D Savage - 9 Jan 2002
Disease Usual phenotype acute leukemia precursor chronic leukemia low grade lymphoma myeloma differentiated Total WBC > 60 leukemoid reaction acute leukemia Blast Pro Myel Meta Band Seg Lymph 0 0 0 2
More informationMANIFEST Phase 2 Enhancement / Expansion
MANIFEST Phase 2 Enhancement / Expansion Investor Conference Call Stellar Science, Breakthrough Medicine October 11, 2018 Forward-Looking Statements This presentation contains forward-looking statements
More informationHow I Treat Myelofibrosis. Adam Mead, MD, PhD University of Oxford Oxford, United Kingdom
How I Treat Myelofibrosis Adam Mead, MD, PhD University of Oxford Oxford, United Kingdom Primary Myelofibrosis Archiv Fur Pathol. 1879;78:475-96. 2 cases of leukemia with peculiar blood and marrow findings
More informationBone Marrow Biopsy in Myelodysplastic Syndromes & Myeloproliferative Neoplasms. A Review for Anatomic Pathologists.
Bone Marrow Biopsy in Myelodysplastic Syndromes & Myeloproliferative Neoplasms A Review for Anatomic Pathologists Bakul I. Dalal MD FRCPC DABP FACP FASCP Clinical Professor, Department of Pathology, UBC
More informationMPL W515L K mutation
MPL W515L K mutation BCR-ABL genotyping The exact chromosomal defect in Philadelphia chromosome is a translocation. Parts of two chromosomes, 9 and 22, switch places. The result is a fusion gene, created
More informationCLINICAL POLICY DEPARTMENT: Medical Management DOCUMENT NAME: JakafiTM REFERENCE NUMBER: NH.PHAR.98
PAGE: 1 of 6 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted
More informationShould Mutational Status in Primary Myelofibrosis (PMF) Guide Therapy..YES!!!
Should Mutational Status in Primary Myelofibrosis (PMF) Guide Therapy..YES!!! Lindsay Anne Magura Rein, MD Division of Hematologic Malignancies and Cellular Therapy/BMT A Little Bit of History.. 1665 Advanced
More informationHENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD. Part 4 MYELOID NEOPLASMS
HENATOLYMPHOID SYSTEM THIRD YEAR MEDICAL STUDENTS- UNIVERSITY OF JORDAN AHMAD T. MANSOUR, MD Part 4 MYELOID NEOPLASMS Introduction: o Myeloid neoplasms are divided into three major categories: o Acute
More informationAbstract. Hematopathology / Early Prepolycythemic Phase of PV
Hematopathology / Early Prepolycythemic Phase of PV The Significance of Bone Marrow Biopsy and JAK2 V617F Mutation in the Differential Diagnosis Between the Early Prepolycythemic Phase of Polycythemia
More informationASH 2013 Analyst & Investor Event
ASH 2013 Analyst & Investor Event December 9, 2013 John A. Scarlett, MD President & CEO Forward-Looking Statements Except for the historical information contained herein, this presentation contains forward-looking
More informationCOEXISTENCE OF β-thalassemia AND POLYCYTHEMIA VERA: A CHICKEN-AND-EGG DEBATE?
COEXISTENCE OF β-thalassemia AND POLYCYTHEMIA VERA: A CHICKEN-AND-EGG DEBATE? M. DE SLOOVERE (1), L. HARLET (2), S. VAN STEENWEGHEN (3), E. MOREAU (1), D. DE SMET (1) (1) DEPARTMENT OF LABORATORY MEDICINE,
More informationDisclosures for Angela Fleischman
Disclosures for Angela Fleischman Principal investigator role Employee Consultant Major Stockholder Speakers Bureau Scientific Advisory Board Sierra, Incyte None None None Incyte None Presentation includes
More informationLondon Cancer. Myelofibrosis guidelines. August Review August Version v1.0. Page 1 of 12
London Cancer Myelofibrosis guidelines August 2013 Review August 2013 Version v1.0 Page 1 of 12 CONTENTS 1. DIAGNOSIS... 3 1a. BCSH (2012)... 3 1b. WHO (2009) diagnostic criteria for PMF:... 4 2. MOLECULAR
More informationBeyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure
Beyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure I am receiving an honorarium from Sysmex for today s presentation. 1 Determining the Etiology for
More informationKeynote Forum. Hematologists Day 1. conferenceseries.com. 5 th World Hematologists Congress. 622 th Conference. August 18-19, 2016 London, UK
622 th Conference Keynote Forum Day 1 Page 21 C D Atreya, 2016, 7:4 (Suppl) C D Atreya U S Food and Drug Administration, USA MicroRNAs in stored blood cells: What future do they hold in transfusion medicine?
More informationHow to monitor MPN patients
How to monitor MPN patients MPN carries significant burden and risk Transformation to MF or AML 1 Neurological complications 2 MPN-associated general symptoms (eg, pruritus, fatigue) 3 Microvascular symptoms
More informationDisclosures for Ayalew Tefferi
Disclosures for Ayalew Tefferi Principal investigator role Employee Consultant Major Stockholder Speakers Bureau Scientific Advisory Board Janssen, Geron, Celgene, Sanofi-Aventis, Gilead Sciences, Incyte
More informationTransplants for MPD and MDS
Transplants for MPD and MDS The question is really who to transplant, with what and when. Focus on myelofibrosis Jeff Szer Royal Melbourne Hospital Myelodysplasia Little needs to be said Despite new therapies
More informationThe Internists Approach to Polycythemia and Implications of Uncontrolled Disease
The Internists Approach to Polycythemia and Implications of Uncontrolled Disease Mary Jo K. Voelpel, DO, FACOI, MA, CS Associate Clinical Professor MSU-COM Disclosures NONE Overview 1. Objectives 2. Case
More informationLatest updates in Myeloproliferative Neoplasms. Elizabeth Hexner, MD, MSTR
Latest updates in Myeloproliferative Neoplasms Elizabeth Hexner, MD, MSTR Disclosures Nothing to disclose Agenda/Goals Treatment goals in PV Indications for cytoreduction in patients polycythemia vera
More informationCHALLENGING CASES PRESENTATION
CHALLENGING CASES PRESENTATION Michael C. Wiemann, MD, FACP Program Co-Chair and Vice President Indy Hematology Education President, Clinical St. John Providence Physician Network Detroit, Michigan 36
More informationPost-ASH 2015 CML - MPN
Post-ASH 2015 CML - MPN Fleur Samantha Benghiat, MD, PhD Hôpital Erasme, Brussels 09.01.2016 1. CML CML 1st line ttt Prognosis Imatinib Nilotinib Response Discontinuation Dasatinib Low RISK PROFILE High
More informationCharacterization of MPL-mutated myeloid neoplasms: a review of 224 MPL+ cases
Article Characterization of MPL-mutated myeloid neoplasms: a review of 224 MPL+ cases Keming Lin 1,*, Gang Xu 1, Jie-Gen Jiang 1, Mayuko Imai 1, Zhao Wu 1, Paris Petersen 1, Kim Janatpour 1, and Bashar
More informationTreatment of polycythemia vera with recombinant interferon alpha (rifnα)
Treatment of polycythemia vera with recombinant interferon alpha (rifnα) Richard T. Silver, MD Professor of Medicine Weill Cornell Medical College New York, New York Outline of Lecture What are interferons?
More informationThe Evolving Role of Transplantation for MPN
The Evolving Role of Transplantation for MPN (PMF, PV, ET) H.Joachim Deeg MD Fred Hutchinson Cancer Research Center, University of Washington, Seattle WA, SCCA jdeeg@fhcrc.org 10 th J. Niblack Conference
More informationJAK2 V617F analysis. Indication: monitoring of therapy
JAK2 V617F analysis BCR-ABL genotyping The exact chromosomal defect in Philadelphia chromosome is a translocation. Parts of two chromosomes, 9 and 22, switch places. The result is a fusion gene, created
More informationNew Therapies for MPNs
Pomalidomide and IMIDS in Myelofibrosis New Therapies for MPNs Fourth International Workshop on CML and MPN Natchez Louisiana Ruben A. Mesa, MD Professor of Medicine Mayo Clinic College of Medicine Director
More informationMyeloid neoplasms. Early arrest in the blast cell or immature cell "we call it acute leukemia" Myoid neoplasm divided in to 3 major categories:
Myeloid neoplasms Note: Early arrest in the blast cell or immature cell "we call it acute leukemia" Myoid neoplasm divided in to 3 major categories: 1. AML : Acute myeloid leukemia(stem cell with myeloid
More informationPolycythemia Vera: From New, Modified Diagnostic Criteria to New Therapeutic Approaches
Polycythemia Vera: From New, Modified Diagnostic Criteria to New Therapeutic Approaches Margherita Maffioli, MD, Barbara Mora, MD, and Francesco Passamonti, MD Drs Maffioli and Mora are hematologists in
More informationMPNs: JAK2 inhibitors & beyond. Mohamed Abdelmooti (MD) NCI, Cairo University, Egypt
MPNs: JAK2 inhibitors & beyond Mohamed Abdelmooti (MD) NCI, Cairo University, Egypt Myeloproliferative Neoplasms (MPNs) AGENDA: 1. Molecular biology 2. New WHO diagnostic criteria. 3. Risk stratification
More informationHeme 9 Myeloid neoplasms
Heme 9 Myeloid neoplasms The minimum number of blasts to diagnose acute myeloid leukemia is 5% 10% 20% 50% 80% AML with the best prognosis is AML with recurrent cytogenetic abnormality AML with myelodysplasia
More informationCase Presentation. Attilio Orazi, MD
Case Presentation Attilio Orazi, MD Weill Cornell Medical College/ NYP Hospital Department of Pathology and Laboratory Medicine New York, NY United States History 60 year old man presented with anemia
More informationCase Report Immune Thrombocytopenia and JAK2V617F Positive Essential Thrombocythemia: Literature Review and Case Report
Hindawi Case Reports in Hematology Volume 2017, Article ID 3725089, 4 pages https://doi.org/10.1155/2017/3725089 Case Report Immune Thrombocytopenia and JAK2V617F Positive Essential Thrombocythemia: Literature
More informationPhiladelphia chromosome-negative chronic myeloproliferative neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Annals of Oncology 26 (Supplement 5): v85 v99, 2015 doi:10.1093/annonc/mdv203 Published online 4 August 2015 Philadelphia chromosome-negative chronic myeloproliferative neoplasms: ESMO Clinical Practice
More informationEuropean Focus on Myeloproliferative Diseases and Myelodysplastic Syndromes A critical reappraisal of anagrelide in the management of ET
European Focus on Myeloproliferative Diseases and Myelodysplastic Syndromes 2012 Clinical i l Aspects of Polycythemia and Essential Thrombocythemia A critical reappraisal of anagrelide in the management
More informationCASE 106. Pancytopenia in the setting of marrow hypoplasia, a PNH clone, and a DNMT3A mutation
CASE 106 Pancytopenia in the setting of marrow hypoplasia, a PNH clone, and a DNMT3A mutation Gabriel C. Caponetti, MD University of Pennsylvania, US Clinical history 69, F peripheral neuropathy, refractory
More informationHighest rates of thrombosis = age > 70, history of thrombosis, active disease (> 6 phlebotomies/yr) [2]
Polycythemia Vera Treatment Policy Prepared by Dr. Jeannie Callum Updated May 2003 Introduction PV is a chronic, clonal, myeloproliferative disorder, classically associated with an increase in red cell
More informationChronic Myeloproliferative Disorders
1 Chronic Myeloproliferative Disorders 15th 9 April2015 Polycythemia vera Essential thrombocythemia Idiopathic primary myelofibrosis 2 Learning objectives To appreciate types of polycythaemia (erythrocytosis)
More informationStifel Nicolaus 2013 Healthcare Conference. John Scarlett, M.D. Chief Executive Officer September 11, 2013
Stifel Nicolaus 2013 Healthcare Conference John Scarlett, M.D. Chief Executive Officer September 11, 2013 1 forward-looking statements Except for the historical information contained herein, this presentation
More informationCommon Consultations in Outpatient Hematology in 30 mins. Lala Cornelius, MD
Common Consultations in Outpatient Hematology in 30 mins Lala Cornelius, MD Disclosures: None Objectives: 1- Decrease referrals to heme/onc for mild heme abnormalities (leukocytosis, thrombocytopenia)
More informationCLINICAL CASE PRESENTATION
European Winter School of Internal Medicine 2015 Riga, Latvia, 26-30 January CLINICAL CASE PRESENTATION Vasiliy Chulkov South Ural State Medical University (Chelyabinsk, Russia) CHELYABINSK CLINICAL HISTORY
More informationDisclosure: Objectives/Outline. Leukemia: Genealogy of Pathology Practice: Old Diseases New Expectations. Nothing to disclose.
RC1 Leukemia: Genealogy of Pathology Practice: Old Diseases New Expectations RC2 Disclosure: Nothing to disclose Henry Moon Lecture: UCSF Annual Conference Kathryn Foucar, MD kfoucar@salud.unm.edu May
More informationShould Mutation Status in PMF Guide Therapy? No! Brady L. Stein, MD MHS Assistant Professor of Medicine Division of Hematology/Oncology
Should Mutation Status in PMF Guide Therapy? No! Brady L. Stein, MD MHS Assistant Professor of Medicine Division of Hematology/Oncology Case presentation A 67 yo woman presents to transition care, as her
More informationMayo Clinic Treatment Strategy in Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis 2013 Update
Mayo Clinic Treatment Strategy in Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis 2013 Update Ayalew Tefferi Mayo Clinic, Rochester, MN 0 20 40 60 80 100 Percent Survival in 337 Mayo Clinic
More informationMasked polycythaemia vera: presenting features, response to treatment and. clinical outcomes. Running title: masked polycythaemia vera.
Masked polycythaemia vera: presenting features, response to treatment and clinical outcomes Running title: masked polycythaemia vera Alberto Alvarez-Larrán 1, Anna Angona 1, Agueda Ancochea 1, Francesc
More informationJohn L Frater, MD Jeffery M Klco, MD, PhD Department of Pathology and Immunology Washington University School of Medicine St Louis, Missouri
Myeloproliferative Neoplasms: New Approaches to Diagnosis and Disease Monitoring John L Frater, MD Jeffery M Klco, MD, PhD Department of Pathology and Immunology Washington University School of Medicine
More informationLymphoma Case Scenario 1
Lymphoma Case Scenario 1 HISTORY: A 23-year-old healthy female presented with a month-long history of persistent headache of increasing severity. She noted episodic nausea and vomiting in association with
More informationCME Information: Primary myelofibrosis: 2017 update on diagnosis, risk-stratification and management
CME ARTICLE AJH CME Information: Primary myelofibrosis: 2017 update on diagnosis, risk-stratification and management CME Editor: Ayalew Tefferi, M.D. Author: Ayalew Tefferi, M.D. If you wish to receive
More information"Calreticulin Mutation Analysis in Iranian patients suffering from Essential thrombocythemia and Primary Myelofibrosis
"Calreticulin Mutation Analysis in Iranian patients suffering from Essential thrombocythemia and Primary Myelofibrosis Dr Behzad Poopak, DCLS PhD. Associate professor of fhematology Islamic Azad University
More informationIntegrated Diagnostic Approach to the Classification of Myeloid Neoplasms. Daniel A. Arber, MD Stanford University
Integrated Diagnostic Approach to the Classification of Myeloid Neoplasms Daniel A. Arber, MD Stanford University What is an integrated approach? What is an integrated approach? Incorporating all diagnostic
More informationEssential thrombocythemia treatment algorithm 2018
Tefferi et al. (2018) 8:2 DOI 10.1038/s41408-017-0041-8 CURRENT TREATMENT ALGORITHM Essential thrombocythemia treatment algorithm 2018 Ayalew Tefferi 1, Alessandro M. Vannucchi 2 and Tiziano Barbui 3 Open
More informationMutational Analysis of EXON 9 of the CALR Gene (Reference )
Mutational Analysis of EXON 9 of the CALR Gene (Reference 2014.01.002) Notice of Assessment June 2014 DISCLAIMER: This document was originally drafted in French by the Institut national d'excellence en
More information