Haploidentical Transplantation today: and the alternatives
|
|
- Duane Clark
- 6 years ago
- Views:
Transcription
1 Haploidentical Transplantation today: and the alternatives Daniel Weisdorf MD University of Minnesota February, 2013
2 No matched sib: where to look? URD donor requires close HLA matching and 3-12 weeks for searching Unrelated donor UCB is validated: numerous published series & registry studies Haplo-identical related donor HCT were tested in 1970s but rarely performed due to: excess GVHD or prolonged immmunodeficiency New Haplo approaches are promising
3 UCB vs Haplo Similarities
4 Differences ~$40,000 per unit
5 >500,000 >18,000,000
6 UCB outcomes children
7 UCB outcomes adults
8
9
10
11 UCB Grafting: Adults AML CR1
12 Sources of Partial Matched Grafts Haploidentical relatives Parents or children Partially matched siblings; cousins G-CSF mobilized PBSC CD34+ selected G-CSF stimulated BM G-CSF mobilized CD34+ BM Unmanipulated BM Unmanipulated PBSC
13 Conditioning for Haplo Transplants Myeloablative TBI or Bu Cy ± Fludarabine Treosulfan or Thiotepa RIC TBI 200cGy Cy 50 mg/kg Fludarabine 40 mg/m2 x 4 GVHD prophylaxis T depleted graft + none CSA/Tac ± MMF± Mtx ATG Anti T or B monoclonal Abs Sirolimus + MMF or Tac Post-HCT cyclophosphamide
14 Limitations of Haploidentical Transplant Increased Alloreactivity Initial study at Marsden using unmanipulated marrow after TBI/Cy 10/35 with graft failure 12/35 died of hyperacute GVHD Powles et al Lancet 1983
15 Limitations of Haploidentical Transplant Increased Alloreactivity Early studies showed equivalent outcome for 5/6 donors Increased GVHD but also reduced relapse Poor outcomes for 3/6 and 4/6 donors with standard regimens Beatty et al NEJM 1985 Anasetti et al NEJM 1989
16 Haplo transplant Approaches *CD34+ selection Pathogen specific lymphocytes TK-transduced IL-10 anergized Photo-allodepleted CD8 negative Treg supplemented CD3-/CD19- CD3 (α/β) depleted Unmanipulated BM [or PBSC] *Cyclophosphamide day +3,+4 Basiliximab, CSA Sirolimus
17 Haplo Problems Cost Technical challenges for manipulations Delayed immune recovery Infections; Relapse Mortality Haplo Advantages Nearly universal Rapidly available Simple if unmanipulated Suicide T cells Ag specific T cells Tregs Specific T cell populations
18
19 Haplo HCT for High risk Adult Acute Leukemia: EBMT Ciceri, Blood 2006
20
21 TRAMM and Haplo Grafting
22 Intensive Immunosuppression 820 patients with hematologic malignancies received busulfan, cytarabine, cyclophosphamide, rabbit ATG Unmanipulated GCSF-stimulated bone marrow. GVHD prophylaxis with MMF, cyclosporine, MTX Grades II to IV acute GVHD 42.9% 3-year leukemia-free survival (LFS) 67.9% & 48.8% in standard-risk and high-risk groups Beijing Regimen Chang and Huang Curr Opin Hematol 2012
23 Intensive Immunosuppression Italian Study Unmanipulated, GCSF-primed BMT Neutrophil engraftment 93% Grade II-IV & III-IV acute GVHD 24% & 5% 3-year probability of DFS for standard-risk and high-risk patients 44% and 30% Di Bartolomeo et al Blood 2012
24 Current Haploidentical Regimens Intensive Immunosuppression Depletion alloreactive cells Post transplant Cyclophosphamide Anergization Megadose CD34-enriched cells CD34 selection T cell depletion
25 Post-Transplant Cyclophosphamide
26 Luznik, BBMT, 2008
27
28 Update RIC Haplo BMT Hopkins N=210 5 year outcomes 87% engraftment GVHD II-IV 27% cgvhd 13% Non-relapse mortality 18% Relapse 55% Survival 35% Event-free survival 27% Munchel, Pediatric Reports, 2011 Fuchs Curr Opin Hematol 2012 Age 52 (1-73) M:F 149:61 Ac Leukemia 59 Ch Leukemia 33 MDS/MPN 16 NHL/HL 66/30 MM 6 Donor Age 42 (14-73) Parents 35 Sib/half sib 102 Children 73
29 Munchel, Pediatric Reports, 2011
30 Update RIC Haplo BMT Hopkins Munchel, Pediatric Reports, 2011
31 Post Transplant Cyclophosphamide Benefits Easy to use Exportable to many centers Low non-relapse and infectious mortality Concerns Significant relapse rate
32 Treatment Regimens Minnesota Protocol (0604) Hopkins Protocol (0603)
33 BMT CTN: Parallel trials of RIC UCB and Haplo BM HCT for Heme malignancies Brunstein, Blood 2011
34 GVHD
35 BMT CTN: Parallel trials RIC HCT for Heme malignancies CTN-0604 Double UCB CTN-0603 Haplo-BM Brunstein, Blood, 2011
36 A Multi-Center, Phase III, Randomized Trial of Reduced Intensity (RIC) Conditioning and Transplantation of Double Unrelated Umbilical Cord Blood (ducb) versus HLA-Haploidentical Related Bone Marrow (Haplo) for Patients with Hematologic Malignancies BMT CTN PROTOCOL 1101 Patient 18 and 70 yrs. Acute leukemia or lymphoma Adequate organ function Performance score 70 Available both Double cord graft Haploidentical related donor Randomization Stratified by Transplant Center Primary Endpoint Progression-free survival at 2 yrs Secondary Endpoints Engraftment GVHD Relapse TRM Immune reconstitution Quality of Life Cost Effectiveness Double UCB Haplo-BM
37
38 Ex vivo T Cell Anergization Induction of alloantigen-specific anergy by co-culturing donor bone marrow and host irradiated PBMC with CTLA-4-IG (n=19) or anti B7.1 and B7.2 (n=5) Less than expected GVHD Low incidence infection and relapse 12/24 died of TRM Guinan et al NEJM 1999 Davies et al Blood 2008
39 Megadose CD34-selected cells GCSF stimulation donor followed by CD34 selection 3-4 log T cell depletion High engraftment (>95%) Low GVHD (<10%) 48% DFS in AML 46% DFS in ALL Aversa et al NEJM 1998 Aversa et al J Clin Oncol 2005
40 Baylor Pediatric DFS after CD34-selected Haploidentical Transplant for Hematologic Malignancy se % Years post transplant
41 Causes of Failure Relapse 21% Infection 22%
42 CD34 Selection Benefits Minimal GVHD Good engraftment Concerns More complex manufacturing (IND) Delayed immune recovery increases risk of infections Significant relapse rate
43 T Cell Depletion CD3 or CD3/19 depleted PBSC Pediatric series, selective T cell depletion has resulted in 2 year event free survival of 26-88% In adults resulted in survival at 1 and 2 years of 41 and 28% Handgretinger et al Curr Opin Hematology 2012 Federmann et al Haematologica 2012
44 Outcomes With Different Approaches Difficult to compare with selection bias in all studies CD34 selection more common in Europe, pediatrics and nonmalignant disease Intensive immunosuppression more common in China
45 In 2012 and beyond Nearly all will have a donor Sib URD UCB Haplo But situational choices Age Performance status Disease and risk *Center Expertise Urgency These should all influence these donor and graft choices
Haploidentical Transplantation: The Answer to our Donor Problems? Mary M. Horowitz, MD, MS CIBMTR, Medical College of Wisconsin January 2017
Haploidentical Transplantation: The Answer to our Donor Problems? Mary M. Horowitz, MD, MS CIBMTR, Medical College of Wisconsin January 2017 Allogeneic Transplant Recipients in the US, by Donor Type 9000
More informationHaplo vs Cord vs URD Debate
3rd Annual ASBMT Regional Conference for NPs, PAs and Fellows Haplo vs Cord vs URD Debate Claudio G. Brunstein Associate Professor University of Minnesota Medical School Take home message Finding a donor
More informationCurrent Status of Haploidentical Hematopoietic Stem Cell Transplantation
Current Status of Haploidentical Hematopoietic Stem Cell Transplantation Annalisa Ruggeri, MD, PhD Hematology and BMT Unit Hôpital Saint Antoine, Paris, France #EBMTITC16 www.ebmt.org Hematopoietic SCT
More informationWhat s new in Blood and Marrow Transplant? Saar Gill, MD PhD Jan 22, 2016
What s new in Blood and Marrow Transplant? Saar Gill, MD PhD Jan 22, 2016 Division of Hematology-Oncology University of Pennsylvania Perelman School of Medicine 1 Who should be transplanted and how? Updates
More informationThe National Marrow Donor Program. Graft Sources for Hematopoietic Cell Transplantation. Simon Bostic, URD Transplant Recipient
1988 199 1992 1994 1996 1998 2 22 24 26 28 21 212 214 216 218 Adult Donors Cord Blood Units The National Donor Program Graft Sources for Hematopoietic Cell Transplantation Dennis L. Confer, MD Chief Medical
More informationHigh dose cyclophosphamide in HLAhaploidentical
High dose cyclophosphamide in HLAhaploidentical stem cell transplantation Ephraim J. Fuchs, M.D., M.B.A. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins fuchsep@jhmi.edu Alternative Donor Transplantation:
More informationHaploidentical Donor Transplants: Outcomes and Comparison to Other. Paul V. O Donnell BSBMT Education Day London 12 October 2011
Haploidentical Donor Transplants: Outcomes and Comparison to Other Donor Types Paul V. O Donnell BSBMT Education Day London 12 October 2011 Clinical Problem: Identification of a Donor for Allogeneic Transplantation
More informationReduced-intensity Conditioning Transplantation
Reduced-intensity Conditioning Transplantation Current Role and Future Prospect He Huang M.D., Ph.D. Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine,
More informationStem Cell Transplantation
Stem Cell Transplantation Evelyne Willems Centre Hospitalier Universitaire, ULg, Liège Post-ASH meeting, January 11, 2012, Brussels Plan 1. Select the patient: validation of HCT-CI 2. Select the donor
More informationThe future of HSCT. John Barrett, MD, NHBLI, NIH Bethesda MD
The future of HSCT John Barrett, MD, NHBLI, NIH Bethesda MD Transplants today Current approaches to improve SCT outcome Optimize stem cell dose and source BMT? PBSCT? Adjusting post transplant I/S to minimize
More informationAllogeneic Hematopoietic Stem Cell Transplantation: State of the Art in 2018 RICHARD W. CHILDS M.D. BETHESDA MD
Allogeneic Hematopoietic Stem Cell Transplantation: State of the Art in 2018 RICHARD W. CHILDS M.D. BETHESDA MD Overview: Update on allogeneic transplantation for malignant and nonmalignant diseases: state
More informationHaploidentical Transplants for Lymphoma. Andrea Bacigalupo Universita Cattolica Policlinico Gemelli Roma - Italy
Haploidentical Transplants for Lymphoma Andrea Bacigalupo Universita Cattolica Policlinico Gemelli Roma - Italy HODGKIN NON HODGKIN Non Myelo Ablative Regimen Luznik L et al BBMT 2008 Comparison of Outcomes
More informationMyeloablative and Reduced Intensity Conditioning for HSCT Annalisa Ruggeri, MD, Hôpital Saint Antoine Eurocord- Hôpital Saint Louis, Paris
Myeloablative and Reduced Intensity Conditioning for HSCT Annalisa Ruggeri, MD, Hôpital Saint Antoine Eurocord- Hôpital Saint Louis, Paris 18th ESH - EBMT Training Course on HSCT 8-10 May 2014, Vienna,
More informationThe question is not whether or not to deplete T-cells, but how to deplete which T-cells
The question is not whether or not to deplete T-cells, but how to deplete which T-cells CD34+ positive selection Negative Depletion of: CD3/CD19 TcRαβ/CD19 T-cell depletion: positive selection versus negative
More informationWhat s a Transplant? What s not?
What s a Transplant? What s not? How to report the difference? Daniel Weisdorf MD University of Minnesota Anti-cancer effects of BMT or PBSCT [HSCT] Kill the cancer Save the patient Restore immunocompetence
More informationALLOGENEIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOBLASTIC LEUKEMIAS
ALLOGENEIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOBLASTIC LEUKEMIAS Didier Blaise, MD Transplant and Cellular Therapy Unit (U2T) Department of Hematology Centre de Recherche en Cancérologie, Inserm U891
More informationRob Wynn RMCH & University of Manchester, UK. HCT in Children
Rob Wynn RMCH & University of Manchester, UK HCT in Children Summary Indications for HCT in children Donor selection for Paediatric HCT Using cords Achieving engraftment in HCT Conditioning Immune action
More informationEBMT Complications and Quality of Life Working Party Educational Course
EBMT Complications and Quality of Life Working Party Educational Course Organisers: R. Duarte, G. Basak 23-24 October 2014, Warsaw, Poland #EBMT2014 www.ebmt.org EBMT Complications and Quality of Life
More informationUmbilical Cord Blood Transplantation
Umbilical Cord Blood Transplantation Current Results John E. Wagner, M.D. Blood and Marrow Transplant Program and Stem Cell Institute University of Minnesota Donor Choices Unrelated Marrow/PBSC Results
More informationRIC in Allogeneic Stem Cell Transplantation
RIC in Allogeneic Stem Cell Transplantation Rainer Storb, MD Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine Seattle, WA Disclosure Grant Support: NIH grants
More informationHLA Haploidentical Transplantation:
HLA Haploidentical Transplantation: The Journey to the Transplantation For All Kitsada Wudhikarn, MD Division of Hematology, Department of Medicine King Chulalongkorn Memorial Hospital Disclosure No relevant
More informationBone Marrow Transplantation and the Potential Role of Iomab-B
Bone Marrow Transplantation and the Potential Role of Iomab-B Hillard M. Lazarus, MD, FACP Professor of Medicine, Director of Novel Cell Therapy Case Western Reserve University 1 Hematopoietic Cell Transplantation
More informationIn-vitro T-cell Depletion is Not Necessary for Haplo-identical Transplantation
In-vitro T-cell Depletion is Not Necessary for Haplo-identical Transplantation Xiao-Jun Huang M.D. Peking University Institute of Hematology (PUIH), Peking University People s Hospital, Beijing Key Laboratory
More informationIntroduction to Clinical Hematopoietic Cell Transplantation (HCT) George Chen, MD Thursday, May 03, 2018
Introduction to Clinical Hematopoietic Cell Transplantation (HCT) George Chen, MD Thursday, May 03, 2018 The transfer of hematopoietic progenitor and stem cells for therapeutic purposes Hematopoietic Cell
More informationNiCord Single Unit Expanded Umbilical Cord Blood Transplantation: Results of Phase I/II Trials
NiCord Single Unit Expanded Umbilical Cord Blood Transplantation: Results of Phase I/II Trials Mitchell E. Horwitz, MD Duke University Medical Center Duke Cancer Institute Adult Umbilical Cord Blood Transplantation
More informationMUD SCT. Pimjai Niparuck Division of Hematology, Department of Medicine Ramathibodi Hospital, Mahidol University
MUD SCT Pimjai Niparuck Division of Hematology, Department of Medicine Ramathibodi Hospital, Mahidol University Outlines Optimal match criteria for unrelated adult donors Role of ATG in MUD-SCT Post-transplant
More informationDoes NK cell alloreactivity prevent relapse? Yes!!! Andrea Velardi Bone Marrow Transplant Program University of Perugia
Does NK cell alloreactivity prevent relapse? Yes!!! Andrea Velardi Bone Marrow Transplant Program University of Perugia Recognition of missing self HLA triggers lysis NK Inhibitory receptor Activating
More informationAIH, Marseille 30/09/06
ALLOGENEIC STEM CELL TRANSPLANTATION FOR MYELOID MALIGNANCIES Transplant and Cellular Therapy Unit Institut Paoli Calmettes Inserm U599 Université de la Méditerranée ée Marseille, France AIH, Marseille
More informationSamples Available for Recipient and Donor
Unrelated HCT Research Sample Inventory - Summary for First Allogeneic Transplants in CRF and TED with biospecimens available through the CIBMTR Repository stratified by availability of paired samples,
More informationSamples Available for Recipient Only. Samples Available for Recipient and Donor
Unrelated HCT Research Sample Inventory - Summary for First Allogeneic Transplants in CRF and TED with biospecimens available through the CIBMTR Repository stratified by availability of paired samples,
More informationCord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014
Cord Blood Transplant E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell
More informationMATCHMAKER, MATCHMAKER, MAKE ME A MATCH, FIND ME A MISMATCHED TRANSPLANT TO CATCH
MATCHMAKER, MATCHMAKER, MAKE ME A MATCH, FIND ME A MISMATCHED TRANSPLANT TO CATCH TEJASWINI M. DHAWALE, M.D. HEME FELLOWS CONFERENCE NOVEMBER 08, 2013 CASE PRESENTATION 51 yo M with history of MDS (unilinear
More informationAlloreattività e Tolleranza nei Trapianti di Cellule Staminali Emopoietiche Allogeniche
Alloreattività e Tolleranza nei Trapianti di Cellule Staminali Emopoietiche Allogeniche Massimo Fabrizio Martelli Ematologia ed Immunologia Clinica Università degli Studi di Perugia 41 Congresso Nazionale
More informationRapid and Robust CD4+ and CD8+ T-, NK-, BTitel and Monocyte Cell Reconstitution after Nicotinamide-Expanded Cord Blood (NiCord) Transplantation
Rapid and Robust CD4+ and CD8+ T-, NK-, BTitel and Monocyte Cell Reconstitution after Nicotinamide-Expanded Cord Blood (NiCord) Subtitel Transplantation Boelens/Nierkens lab Jaap Jan Boelens, Central Immune
More informationAuthors: Xiaotong Yu, Liping Liu, Zhenwei Xie, Chongya Dong, Libo Zhao, Jingru Zhang, Hong-Hu Zhu, Jian Gu. Critical Reviews in Oncology/Hematology
Accepted Manuscript Title: Bone Marrow Versus Peripheral Blood as a Graft Source for Haploidentical Donor Transplantation in Adults Using Post-Transplant Cyclophosphamide A Systematic Review and Meta-Analysis
More informationShall young patients with severe aplastic anemia without donors receive BMT from alternative source of HCT? Elias Hallack Atta, MD, PhD
Shall young patients with severe aplastic anemia without donors receive BMT from alternative source of HCT? Elias Hallack Atta, MD, PhD Declaração de Conflito de Interesse Declaro que possuo conflito de
More informationBusulfan/Cyclophosphamide (BuCy) versus Busulfan/Fludarabine (BuFlu) Conditioning Regimen Debate
Busulfan/Cyclophosphamide (BuCy) versus Busulfan/Fludarabine (BuFlu) Conditioning Regimen Debate Donald Hutcherson, RPh Clinical Pharmacy Specialist BMT Emory University Hospital/Winship Cancer Institute
More informationHematopoietic Stem Cell Transplantation for Fanconi Anemia
Hematopoietic Stem Cell Transplantation for Fanconi Anemia John E. Wagner, M.D. Blood and Marrow Transplant Program University of Minnesota Cell Therapy for Pediatric Diseases NHLBI PACT Workshop 14 15
More informationBack to the Future: The Resurgence of Bone Marrow??
Back to the Future: The Resurgence of Bone Marrow?? Thomas Spitzer, MD Director. Bone Marrow Transplant Program Massachusetts General Hospital Professor of Medicine, Harvard Medical School Bone Marrow
More informationTrapianto allogenico
POST ASH 2013: 3 Workshop Regionale Marchigiano 28 Febbraio - 1 Marzo 2014 Hotel Domus Stella Maris, ANCONA REPORT OF THE BEST ASH NEWS Trapianto allogenico Dr. Claudio Giardini U.O. Ematologia e Centro
More informationStem Cell Transplantation for Severe Aplastic Anemia
Number of Transplants 10/24/2011 Stem Cell Transplantation for Severe Aplastic Anemia Claudio Anasetti, MD Professor of Oncology and Medicine Chair, Blood and Marrow Transplant Dpt Moffitt Cancer Center
More informationTrends in Hematopoietic Cell Transplantation. AAMAC Patient Education Day Oct 2014
Trends in Hematopoietic Cell Transplantation AAMAC Patient Education Day Oct 2014 Objectives Review the principles behind allogeneic stem cell transplantation Outline the process of transplant, some of
More informationHaploidentical Stem Cell Transplantation with post transplantation Cyclophosphamide for the treatment of Fanconi Anemia
Haploidentical Stem Cell Transplantation with post transplantation Cyclophosphamide for the treatment of Fanconi Anemia Carmem Bonfim Director Pediatric Blood and Marrow Transplantation Program HC Federal
More informationAML:Transplant or ChemoTherapy?
AML:Transplant or ChemoTherapy? 1960 s: Importance of HLA type in Animal Models Survival of Dogs Given 1000 RAD TBI and a Marrow Infusion from a Littermate Matched or Mismatched for Dog Leucocyte Antigens
More informationAn Introduction to Bone Marrow Transplant
Introduction to Blood Cancers An Introduction to Bone Marrow Transplant Rushang Patel, MD, PhD, FACP Florida Hospital Medical Group S My RBC Plt Gran Polycythemia Vera Essential Thrombocythemia AML, CML,
More informationIs in vitro T-cell depletion necessary for Haploidentical TransplantationTitle of Presentation. Disclosure of Interest: Nothing to Disclose
Rupert Handgretinger Children s University Hospital, Tübingen, Germany Is in vitro T-cell depletion necessary for Haploidentical TransplantationTitle of Presentation Disclosure of Interest: Nothing to
More informationSamples Available for Recipient Only. Samples Available for Recipient and Donor
Unrelated HCT Research Sample Inventory - Summary for First Allogeneic Transplants in CRF and TED with biospecimens available through the CIBMTR Repository stratified by availability of paired samples,
More informationUNRELATED DONOR TRANSPLANTATION FOR SICKLE CELL DISEASE AN UPDATE
UNRELATED DONOR TRANSPLANTATION FOR SICKLE CELL DISEASE AN UPDATE Naynesh Kamani, M.D. Children s National Medical Center GW University School of Medicine Washington, DC SCD scope of problem in USA Commonest
More informationExperience of patients transplanted with naïve T cell depleted stem cell graft in CMUH
Experience of patients transplanted with naïve T cell depleted stem cell graft in CMUH Tzu-Ting Chen, Wen-Jyi Lo, Chiao-Lin Lin, Ching-Chan Lin, Li-Yuan Bai, Supeng Yeh, Chang-Fang Chiu Hematology and
More informationCOI disclosure. The International Congress of BMT Name of author : Byong Sik Cho. I have no personal or financial interests to declare:
The International Congress of BMT 2017 COI disclosure Name of author : Byong Sik Cho I have no personal or financial interests to declare: I have no financial support from an industry source at the current
More informationAllo-Hematopoietic Stem Cell Transplant in China: 2014 Update
235 chapter 30 Allo-Hematopoietic Stem Cell Transplant in China: 2014 Update Meng Lv 1 and Xiao-jun Huang 1,2 1 Peking University People s Hospital, Peking University Institute of Hematology, Beijing Key
More informationAllogeneic Hematopoietic Stem Cell Transplant Using Mismatched/Haploidentical Donors
Biology of Blood and Marrow Transplantation 13:1249-1267 (2007) 2007 American Society for Blood and Marrow Transplantation 1083-8791/07/1311-0001$32.00/0 doi:10.1016/j.bbmt.2007.08.003 Allogeneic Hematopoietic
More informationMUD HSCT as first line Treatment in Idiopathic SAA. Dr Sujith Samarasinghe Great Ormond Street Hospital for Children, London, UK
MUD HSCT as first line Treatment in Idiopathic SAA Dr Sujith Samarasinghe Great Ormond Street Hospital for Children, London, UK No Financial Disclosures Guidelines for management of aplastic anaemia British
More informationReview Article Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies
Advances in Hematology Volume 2016, Article ID 3905907, 16 pages http://dx.doi.org/10.1155/2016/3905907 Review Article Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies Kevon
More informationADVANCES IN THE MANAGEMENT OF MYELODYSPLASTIC SYNDROMES
ADVANCES IN THE MANAGEMENT OF MYELODYSPLASTIC SYNDROMES Corey Cutler, MD MPH FRCPC Associate Professor of Medicine, Harvard Medical School Dana-Farber Cancer Institute, Boston, MA HCT Outcomes - MDS 2001-2011
More informationCONSIDERATIONS IN DESIGNING ACUTE GVHD PREVENTION TRIALS: Patient Selection, Concomitant Treatments, Selecting and Assessing Endpoints
CONSIDERATIONS IN DESIGNING ACUTE GVHD PREVENTION TRIALS: Patient Selection, Concomitant Treatments, Selecting and Assessing Endpoints CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH Potential
More informationDisclosure. Objectives 1/22/2015
Evaluation of the Impact of Anti Thymocyte Globulin (ATG) on Post Hematopoietic Stem Cell Transplant (HCT) Outcomes in Patients Undergoing Allogeneic HCT Katie S. Kaminski, PharmD, CPP University of North
More informationAlternative Donor Transplantation for Acute Myeloid Leukemia
J. Clin. Med. 2015, 4, 1240-1268; doi:10.3390/jcm4061240 Review OPEN ACCESS Journal of Clinical Medicine ISSN 2077-0383 www.mdpi.com/journal/jcm Alternative Donor Transplantation for Acute Myeloid Leukemia
More informationAn overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide
CRITICAL REVIEW An overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide AJH Munira Shabbir-Moosajee, 1 Lindsey Lombardi, 2 and Stefan
More informationAcute Graft-versus-Host Disease (agvhd) Udomsak Bunworasate Chulalongkorn University
Acute Graft-versus-Host Disease (agvhd) Udomsak Bunworasate Chulalongkorn University Graft-versus-Host Disease (GVHD) Background GVHD is an immunologic reaction of the donor immune cells (Graft) against
More informationResults of Nicord Phase I II Trials and Plans for Phase III Trial
Results of Nicord Phase I II Trials and Plans for Phase III Trial Mitchell E. Horwitz, MD Duke Cancer Institute Duke University Medical Center June 10, 2016 Learning Objectives To provide an overview of
More informationHaploidentical Transplantation Helen Heslop
Haploidentical Transplantation Helen Heslop Outline Haplodentical transplantation Indications Regimens Outcomes KIR mismatching and NK cells Reconstituting T cell immunity Allodepleted T cells Cytotoxic
More informationA G E N D A CIBMTR WORKING COMMITTEE FOR GRAFT SOURCES & MANIPULATION Salt Lake City, UT Thursday, February 22, 2018, 2:45 4:45 pm
2. Accrual 3. Presentations, Not for publication or presentation A G E N D A CIBMTR WORKING COMMITTEE FOR GRAFT SOURCES & MANIPULATION Salt Lake City, UT Thursday, February 22, 2018, 2:45 4:45 pm Co-Chair:
More informationObjectives. What is Aplastic Anemia. SAA 101: An Introductory Course to Severe Aplastic Anemia
SAA 101: An Introductory Course to Severe Aplastic Anemia David A. Margolis, MD Professor of Pediatrics/Medical College of Wisconsin Program Director/ Children s Hospital of Wisconsin BMT Program Objectives
More informationClinical Use of Umbilical Cord Blood Hematopoietic Stem Cells
Biology of Blood and Marrow Transplantation 12:34-41 (2006) 2006 American Society for Blood and Marrow Transplantation 1083-8791/06/1201-0107$32.00/0 doi:10.1016/j.bbmt.2005.09.006 Clinical Use of Umbilical
More informationPediatric Hematopoietic Stem Cell Transplant - Experience of an Indian Tertiary Care Center
Pediatric Hematopoietic Stem Cell Transplant - Experience of an Indian Tertiary Care Center Dr Chirag A Shah Diplomate American Board of Hematology and Medical Oncology Director, Dept of Hemato-Oncology
More informationDisclosures of: Emanuele Angelucci
Company name Novartis Disclosures of: Emanuele Angelucci Research support Employee Consultant Stockholder Speakers bureau Advisory board Chair of TELESTO pro Other EBMT 2012 Educational Session Haemoglobinopathy
More informationDonatore HLA identico di anni o MUD giovane?
Donatore HLA identico di 60-70 anni o MUD giovane? Stella Santarone Dipartimento di Ematologia, Medicina Trasfusionale e Biotecnologie Pescara AGENDA 1. Stem Cell Donation: fatalities and severe events
More informationHaploidente HSCT bei Sichelzellkrankheit. Selim Corbacioglu Regensburg, Germany
Haploidente HSCT bei Sichelzellkrankheit Selim Corbacioglu Regensburg, Germany Hemoglobinopathies are the largest patient population with an absolute indication for SCT 5% of the world s popula2on are
More information5/9/2018. Bone marrow failure diseases (aplastic anemia) can be cured by providing a source of new marrow
5/9/2018 or Stem Cell Harvest Where we are now, and What s Coming AA MDS International Foundation Indianapolis IN Luke Akard MD May 19, 2018 Infusion Transplant Conditioning Treatment 2-7 days STEM CELL
More informationSummary of Changes BMT CTN 1101 Version 7.0 to 8.0 Dated: January 18, Original text: Changed to: Rationale
BMT CTN 1101 RIC ducb vs. Haplo Page 1 of 10 Date: January 20, 2017 Summary of Changes BMT CTN 1101 Version 7.0 to 8.0 Dated: January 18, 2017 A Multi-Center, Phase III, Randomized Trial of Reduced Intensity(RIC)
More informationCell-based immunotherapy products for the treatment of blood cancers and inherited blood disorders. Company Presentation June 2016
Cell-based immunotherapy products for the treatment of blood cancers and inherited blood disorders Company Presentation June 2016 Disclaimer These slides and the accompanying oral presentation contain
More informationBB&MT. KEY WORDS Acute lymphoblastic leukemia Hematopoietic stem cell transplantation Therapy Adult
Biology of Blood and Marrow Transplantation 12:1-30 (2006) 2006 American Society for Blood and Marrow Transplantation 1083-8791/06/1201-0001$32.00/0 doi:10.1016/j.bbmt.2005.10.018 The Role of Cytotoxic
More informationHematopoietic Stem Cell Transplant in Sickle Cell Disease- An update
Hematopoietic Stem Cell Transplant in Sickle Cell Disease- An update Dr Chirag A Shah Diplomate American Board of Hematology and Medical Oncology Director, Dept of Hemato-Oncology and Stem Cell Transplant
More informationRelated haploidentical donors versus matched unrelated donors
Related haploidentical donors versus matched unrelated donors Bronwen Shaw, MD PhD Professor of Medicine, MCW Senior Scientific Director, CIBMTR Definition Matched Unrelated donor Refers to HLA matching
More informationOne Day BMT Course by Thai Society of Hematology. Management of Graft Failure and Relapsed Diseases
One Day BMT Course by Thai Society of Hematology Management of Graft Failure and Relapsed Diseases Piya Rujkijyanont, MD Division of Hematology-Oncology Department of Pediatrics Phramongkutklao Hospital
More informationAcute GVHD. ESH-EBMT 2009 Latimer A. Devergie
Acute GVHD ESH-EBMT 2009 Latimer A. Devergie Acute GVHD Activated Donor T cells damage host epithelial cells after an inflammatory cascade that begins after the preparative regimen GVHD is the major barrier
More informationDr. Joseph McGuirk Professor of Medicine, BMT Medical Director, Interim Director, Division of Hematology/Oncology
Advances in Autologous and Allogeneic Stem Cell Transplantation Dr. Joseph McGuirk Professor of Medicine, BMT Medical Director, Interim Director, Division of Hematology/Oncology April 12, 2014 Disclosures
More informationA comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia
Piemontese et al. Journal of Hematology & Oncology (2017) 10:24 DOI 10.1186/s13045-017-0394-2 RESEARCH A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated
More information3.1 Clinical safety of chimeric or humanized anti-cd25 (ch/anti-cd25)
3 Results 3.1 Clinical safety of chimeric or humanized anti-cd25 (ch/anti-cd25) Five infusions of monoclonal IL-2 receptor antibody (anti-cd25) were planned according to protocol between day 0 and day
More informationFederica Galaverna, 1 Daria Pagliara, 1 Deepa Manwani, 2 Rajni Agarwal-Hashmi, 3 Melissa Aldinger, 4 Franco Locatelli 1
Administration of Rivogenlecleucel (Rivo-cel, BPX-501) Following αβ T- and B-Cell Depleted Haplo-HSCT in Children With Transfusion-Dependent Thalassemia Federica Galaverna, 1 Daria Pagliara, 1 Deepa Manwani,
More informationUMBILICAL CORD BLOOD STEM CELLS EXPANDED IN THE PRESENCE OF NICOTINAMIDE (NICORD) PROVIDE LONG TERM MULITI-LINEAGE ENGRAFTMENT
UMBILICAL CORD BLOOD STEM CELLS EXPANDED IN THE PRESENCE OF NICOTINAMIDE (NICORD) PROVIDE LONG TERM MULITI-LINEAGE ENGRAFTMENT Mitchell E. Horwitz, MD Duke University Medical Center Duke Cancer Institute
More informationTreatment of Chronic Graft versus Host Disease. Daniel Weisdorf MD University of Minnesota
Treatment of Chronic Graft versus Host Disease Daniel Weisdorf MD University of Minnesota October 2013 Infections Transplant Events d-8 0 1mo 3mo 6mo Conditioning Transplant Engraftment Mucositis Organ
More informationFactors Influencing Haematopoietic Progenitor cell transplant outcome Optimising donor selection
Factors Influencing Haematopoietic Progenitor cell transplant outcome Optimising donor selection Alison Logan Transplantation Laboratory Manchester Royal Infirmary Haematopoietic progenitor cell transplants
More informationHematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist
Review Series ADVANCES IN HEMATOPOIETIC CELL TRANSPLANTATION Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist Natasha
More informationYes Antonio M. Risitano, M.D., Ph.D. Head of Bone Marrow Transplantation Unit Federico II University of Naples
4ème Journée Nationale Maladies Rares Immuno-Hématologiques Paris, June 7th 2018 Matched unrelated upfront transplantation in idiopathic aplastic anemia? Yes Antonio M. Risitano, M.D., Ph.D. Head of Bone
More informationRevista Cubana de Hematología, Inmunología y Hemoterapia. 2017; 36 (Suplemento).
Depletion of TCR alpha/beta+ T-lymphocytes from grafts for haplo haematopoietic CELL transplantation (HCT) in children Heilmann C, Ifversen M, Haastrup E, Fischer-Nielsen A. Haematopoietic Cell Transplantation
More informationINTRODUCTION Rabbit antithymocyte globulin (ratg), a polyclonal antibody that targets human T lymphocytes, is
Total and Active Rabbit Antithymocyte Globulin (ratg;thymoglobulinò) Pharmacokinetics in Pediatric Patients Undergoing Unrelated Donor Bone Marrow Transplantation Sandra K. Call, 1,2 Kimberly A. Kasow,
More informationIan A. Bilmon, John Kwan, David Gottlieb, Ian Kerridge, Mary McGurgan, Gillian Huang, Biju George, Mark Hertzberg, Kenneth F.
1 This is an Accepted Manuscript of an article published in [Intern Med J], available online at http://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.2012.02843.x/abstract (paywalled). Self-archived in
More informationObjectives. Cord Blood is RelaOvely Recent Technology BMT Pharmacists Conference: Debate - Haploidentical vs. Umbilical Cord Blood Transplant
214 BMT Pharmacists Conference: Debate - Haploidentical vs. Umbilical Cord Blood Transplant Claudio G Brunstein Associate Professor of Medicine University of Minnesota Minneapolis, MN Objectives Defend
More informationIl Trapianto da donatore MUD. Alessandro Rambaldi
Il Trapianto da donatore MUD Alessandro Rambaldi Overview Comparison of outcomes of allo- HSCT from matched related and unrelated donors. We need evidence based results! Is the Dme needed to find an unrelated
More informationDr.PSRK.Sastry MD, ECMO
Peripheral blood stem cell transplantation (Haematopoietic stem cell transplantation) Dr.PSRK.Sastry MD, ECMO Consultant, Medical Oncology Kokilaben Dhirubhai Ambani Hospital Normal hematopoiesis Historical
More informationHOPA News. Contents. 12, Issue 2, 2015
HOPA News Volume 12, Issue 2, 2015 Posttransplant Cyclophosphamide: A Unique Approach for Prevention of Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation Ashley Glode, PharmD
More informationBMT CLINICAL TRIALS NETWORK RIC vs. MAC Protocol # 0901 Version 5.0 dated March 3, 2014
Core Study Participants: Baylor College of Medicine (Methodist ) BMT at Northside Hospital Case Western Reserve University Consortia Cleveland Clinic Foundation Oregon Health and Science University University
More informationEBMT2008_22_44:EBMT :29 Pagina 454 CHAPTER 30. HSCT for Hodgkin s lymphoma in adults. A. Sureda
EBMT2008_22_44:EBMT2008 6-11-2008 9:29 Pagina 454 * CHAPTER 30 HSCT for Hodgkin s lymphoma in adults A. Sureda EBMT2008_22_44:EBMT2008 6-11-2008 9:29 Pagina 455 CHAPTER 30 HL in adults 1. Introduction
More informationHematopoietic Cell Transplantation for Myelofibrosis. Outline
Hematopoietic Cell Transplantation for Myelofibrosis H.Joachim Deeg MD Fred Hutchinson Cancer Research Center & University of Washington, Seattle WA Great Debates, NY, 4/28/2012 Outline Rationale for hematopoietic
More informationAbstract. Introduction. Editor: M. Paul
ORIGINAL ARTICLE MYCOLOGY Incidence of invasive fungal disease after unmanipulated haploidentical stem cell transplantation was significantly higher than that after HLA-matched sibling transplantation
More informationDisclosers Updates: Management of Aplastic Anemia and Congenital Marrow Failure 5/9/2017
2017 Updates: Management of Aplastic Anemia and Congenital Marrow Failure Sachit Patel, MD Department of Pediatrics Division of Hematology-Oncology Blood and Marrow Transplantation Disclosers None 1 Objectives:
More informationHLA-DR-matched Parental Donors for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-risk Acute Leukemia
BRIEF COMMUNICATION HLA-DR-matched Parental Donors for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with High-risk Acute Leukemia Shang-Ju Wu, Ming Yao,* Jih-Luh Tang, Bo-Sheng Ko, Hwei-Fang
More informationRole of NMDP Repository in the Evolution of HLA Matching and Typing for Unrelated Donor HCT
Role of NMDP Repository in the Evolution of HLA Matching and Typing for Unrelated Donor HCT Stephen Spellman, MBS Director, Immunobiology and Observational Research Assistant Scientific Director CIBMTR,
More information