Our Clinical Trials. Oncology
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1 Our Clinical Trials Oncology
2 ANGIOGENESIS Trebananib (AMG 86) (angiopoietin inhibitor) ANTIBODY DRUG CONJUGATE, continued AMG 595 (anti-egfrviii) Trebananib With Paclitaxel and Trastuzumab or Capecitabine and Lapatinib in HER-Positive b Glioma First-In-Human Study of AMG Trebananib Plus Paclitaxel With or Without Bevacizumab as First-Line in HER-Negative Trebananib in Combination With FOLFIRI Hepatic Trebananib in Combination With Cisplatin & Capecitabine First-line Therapy of Trebananib in Combination With Sorafenib Trebananib with Pemetrexed and Carboplatin in Open-Label First-line Therapy of Trebananib With Paclitaxel and Carboplatin Trebananib in Combination With Pegylated Liposomal Doxorubicin or Topotecan TRINOVA-: Trebananib in Combination With Paclitaxel in Recurrent Cancer TRINOVA-: Trebananib in Combination With Paclitaxel/Carboplatin in First-Line Therapy b/ Renal Trebananib in Combination With Sunitinib b b BONE METASTASES AND METABOLISM Denosumab (RANK ligand inhibitor) Giant Cell Tumor Multiple Myeloma Prostate CELL CYCLE Denosumab Study in Adjuvant Cancer (D-CARE) Placebo-Controlled Study of Denosumab in Patients Receiving Aromatase Inhibitor Therapy Denosumab in Recurrent or Unresectable Giant Cell Tumor of the Bone Denosumab Compared to Zoledronic Acid for Treatment of Bone Disease in Multiple Myeloma Denosumab Study on Lens Opacifications in Non-Metastatic Patients on ADT and Denosumab in the Treatment of Hypercalcemia Multiple Myeloma of Malignancy AMG 900 (pan-aurora kinase inhibitor) AMG 780 (angiopoietin inhibitor) Trebananib Pharmacokinetics in Cancer Subjects With Normal and Impaired Renal Function Trebananib With Either Motesanib, Bevacizumab, Sorafenib, or Sunitinib AMG 780 First-In-Human Study in Adult Subjects with Advanced ANTIBODY DRUG CONJUGATE AMG 7 (antibody drug conjugate) b Renal First-in-Human Study of AMG 7 in Patients with Kidney Cancer GROWTH REGULATION Rilotumumab (HGF/SF inhibitor) AMG 900 in Adult Subjects With Acute s and Related Disorders AMG 900 First-In-Human Study in Adult Subjects With Advanced Prostate SCLC Rilotumumab or Ganitumab in Combination With Panitumumab Rilotumumab in Combination With Epirubicin, Cisplatin, and Capecitabine RILOMET-: Rilotumumab with ECX in First- Line Treatment for MET-Positive Lower, or GEJ Adenocarcinoma Rilotumumab in Combination With Mitoxantrone and Prednisone Rilotumumab or Ganitumab in Combination With Cisplatin or Carboplatin, and Etoposide b/ b/ b/ b/
3 GROWTH REGULATION, continued AMG 08 (MET inhibitor) GROWTH REGULATION, continued Panitumumab (EGFR inhibitor), continued First-In-Human Study of AMG Panitumumab Pediatric Study AMG 9 (PIKδ inhibitor) Lymphoma AMG 7 (MET inhibitor) AMG 9 First-in-Human Study in Adult Subjects with Lymphoid Malignancy First-in-Human Study of AMG 7 Ganitumab (IGFR antagonist) SCLC Panitumumab (EGFR inhibitor) Panitumumab Plus Irinotecan Followed by Panitumumab Plus Ganitumab Ganitumab or Rilotumumab (AMG 0) in Combination With Cisplatin or Carboplatin, and Etoposide b/ SPIRITT: Second-line Therapy of Panitumumab or Bevacizumab in Combination With FOLFIRI PEAK: First-line Therapy of Panitumumab or Bevacizumab in Combination With mfolfox6 Panitumumab Plus Irinotecan Followed by Panitumumab Plus Ganitumab (AMG 479) Panitumumab With Best Supportive Care (BSC) vs BSC Alone ASPECCT: Panitumumab Efficacy and Safety Compared to Cetuximab in Subjects With WT KRAS mcrc PRISM: Second-line Therapy With Panitumumab CONCERT: Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy PARTNER: Cisplatin and Docetaxel With or Without Panitumumab Pharmacokinetic Study of Chemotherapy With or Without Panitumumab HEMATOPOIESIS Darbepoetin alfa (erythropoiesis-stimulating agent) MDS Other Clinical Trials Darbepoetin alfa for the Treatment of Anemic Subjects With Low or Intermediate- Risk MDS Impact of Darbepoetin alfa on Survival in Anemic Subjects Receiving Chemotherapy Pegfilgrastim (granulocyte colony-stimulating factor) Romiplostim (thrombopoiesis stimulator) MDS FN NOLAN: The Effect of Prophylactic Naproxen or Loratidine on Bone Pain with Chemotherapy and Pegfilgrastim RIAN: The Effect of Patient Education on Reported Bone Pain with Chemotherapy and Pegfilgrastim PAVES: Placebo-Controlled Study of Pegfilgrastim With Bevacizumab and Either FOLFOX or FOLFIRI Interventional Study in Adult Subjects with Receiving Romiplostim Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects With Safety and Efficacy Study of Romiplostim to Treat in Pediatric Subjects Placebo-Controlled Study of Romiplostim (All subjects have been removed from treatment and are being followed for observation) Study to Investigate the Relationship Between Physician-Assessed Febrile Neutropenia (FN) Risk Probability Score and Prediction Tool FN Risk Probability Score for Patients With Non-Myeloid Malignancies n/a
4 IMMUNOTHERAPY Blinatumomab (bispecific T cell engager antibody) Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-Precursor Acute Lymphoblastic Blinatumomab in Patients With Minimal Residual Disease of B-Precursor Acute Lymphoblastic Blinatumomab in Patients With Relapsed/ Refractory B-Precursor Acute Lymphoblastic b/ Amgen s Research and Development Vision Amgen aspires to be the best human therapeutics company. Amgen is committed to developing new therapies to treat serious illnesses a long and careful process. Among the most important steps in this process are the clinical trials, where people volunteer to receive an experimental new drug or procedure and be observed for its effects. Blinatumomab in Adult Patients With Relapsed/ Refractory B-Precursor Acute Lymphoblastic At Amgen, we apply four guiding principles to our research and development efforts. Non-Hodgkin s Lymphoma Safety Study of Blinatumomab in Patients With Relapsed NHL Talimogene Laherparepvec (oncolytic immunotherapy) The first is to focus on grievous illness. Given the difficulty of successfully developing a new therapy, we focus our efforts on developing therapies to help patients suffering from the greatest unmet medical needs. Melanoma TUMOR ASSOCIATED MACROPHAGES AMG 80 (c-fms inhibitor) OPTiM : Talimogene Laherparepvec Compared to GM-CSF in Unresectable Melanoma Our second guiding principle is to be modality independent. Small molecules and biotherapeutics (biologics) each have unique and inherent advantages and disadvantages. Our modality independent approach allows us to leverage the advantageous aspects of a particular approach that are best suited to interdict a disease. First-in-Human Study of AMG Our third major emphasis is to study disease in patients. While it is significantly more complicated to study disease in humans, we believe that this is the only way to successfully develop human therapeutics. Information as of /09/. Statements are based on the company s current beliefs and Amgen disclaims any duty to update. For more information about Amgen and its business, including risks and uncertainties, please refer to Amgen s filings with the SEC. Products under investigational study have not been approved by the FDA for the use under investigation. This information is provided only for purposes of providing general information on clinical trials and stages of development on the select candidates identified. This information should not be construed as a recommendation for use of any product for unapproved uses. *For more detailed information about the trial, visit or Previously referred to as OncoVEX GM-CSF Our fourth guiding principle, seamless integration, informs everything we do. There are important insights that come to basic research and clinical development from understanding the medical marketplace, and vice versa. Aligning our priorities across these functions ensures that we develop potential therapeutics in a manner that will address unmet medical needs and meet the changing demands of the marketplace. OPTiM = OncoVEX GM-CSF Pivotal Trial In Melanoma.
5 Amgen Inc. One Amgen Center Drive Thousand Oaks, CA Amgen Inc. All Rights Reserved. 68-R-V
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