Transform genomic data into real-life results

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1 CLINICAL SUMMARY Transform genomic data into real-life results Biomarker testing and targeted therapies can drive improved outcomes in clinical practice New FDA-Approved Broad Companion Diagnostic for Solid Tumors BRAF Colorectal Cancer EGFR Non-Small Cell Lung Cancer KRAS NRAS ALK BRAF BRCA1 Ovarian Cancer ERBB2 Melanoma BRCA2 Breast Cancer

2 More comprehensive results than single-marker testing FoundationOne CDx is the first next-generation sequencing (NGS) test with FDA-approval across all solid tumors and clinical validation in multiple indications one test proven concordant with multiple companion diagnostics that helps identify patients who may benefit from associated therapies. The approach used by FoundationOne CDx has been shown by our FoundationOne assay to identify more patients, compared with traditional single-gene testing methods, who test positive for genomic alterations in several cancer types. 1-5 PATIENT DISEASE Lung adenocarcinoma NAME Not Given DATE OF BIRTH Not Given SEX Female MEDICAL RECORD # Not Given PATIENT Jane Sample PHYSICIAN ORDERING PHYSICIAN Not Given MEDICAL FACILITY Not Given ADDITIONAL RECIPIENT Not Given MEDICAL FACILITY ID Not Given PATHOLOGIST Not Given TUMOR TYPE TRF# Lung adenocarcinoma TRFXXXXXX SPECIMEN SPECIMEN SITE Not Given SPECIMEN ID Not Given SPECIMEN TYPE Not Given DATE OF COLLECTION Not Given SPECIMEN RECEIVED Not Given 1 FDA-Approved Therapies List of FDA-approved companion diagnostics to identify patients who may benefit from associated therapies CDx Associated Findings GENOMIC FINDINGS DETECTED EGFR 2 L858R FDA-APPROVED THERAPEUTIC OPTIONS Gilotrif (Afatinib) Iressa (Gefitinib) Tarceva (Erlotinib) OTHER ALTERATIONS & BIOMARKERS IDENTIFIED Results reported in this section are not prescriptive or conclusive for labeled use of any specific therapeutic product. See professional services section for additional information. 1 2 All Other Biomarkers All other biomarkers, including tumor mutational burden (TMB) and microsatellite instability (MSI), without companion diagnostic claims Microsatellite Status MS-Stable Tumor Mutation Burden 11 Muts/Mb CDKN2A/B loss EGFR amplification PTCH1 T416S RBM10 Q494* TP53 R267P Refer to appendix for limitation statements related to detection of any copy number alterations, gene rearrangements, MSI or TMB result in this section. Please refer to appendix for Explanation of Clinical Significance Classification and for variants of unknown significance (VUS). SAMPLE REPORT

3 Genomic testing evolved Clinical Validation and Concordance Studies FoundationOne CDx is concordant with seven on-market companion diagnostics (CDx) BIOMARKER EGFR Exon 19 Deletions and L858R POSITIVE-PERCENT AGREEMENT (PPA)* NEGATIVE-PERCENT AGREEMENT (NPA) COMPARATOR METHOD 98.1% (106/108) 99.4% (153/154) cobas EGFR Mutation Test v2 EGFR T790M 98.9% (87/88) 86.1% (93/108) ALK Rearrangements 92.9% (78/84) 100% (75/75) cobas EGFR Mutation Test v1 cobas EGFR Mutation Test v2 Ventana ALK (D5F3) CDx Assay Vysis ALK Break-Apart FISH Probe Kit KRAS 100% (173/173) 100% (154/154) therascreen KRAS RGQ PCR Kit ERBB2 (HER2) Amplifications 89.4% (101/113) 98.4% (180/183) Dako HER2 FISH PharmDx Kit BRAF V600 BRAF V600E 99.4% (166/167) 99.3% (149/150) 89.6% (121/135) 99.2% (121/122) BRAF V600 dinucleotide 96.3% (26/27) 100% (24/24) THxID BRAF kit cobas BRAF V600 Mutation Test Cobas is a trademark of Roche Diagnostics Operations, Inc. Therascreen is a trademark of Qiagen. PharmDx is a registered trademark of Dako Denmark A/S. * The reference standard used to calculate PPA and NPA is defined as the consensus calls between the two comparator methods PPA being when FoundationOne CDx and the comparator method(s) identified mutations in mutated patients and NPA being when FoundationOne CDx and the comparator method(s) did not identify mutations in nonmutated patients. Follow-on CDx claims were based on a non-inferiority statistical testing approach using the enrichment design presented by Li M. Statistical Methods for Clinical Validation of Follow-On Companion Diagnostic Devices via an External Concordance Study. Statistics in Biopharmaceutical Research. Volume 8, 2017 Issue 3: pages Sensitivity of dinucleotide detection of BRAF V600K and V600E was found to be significantly reduced in cobas test, in particular for samples in which FoundationOne CDx detected the dinucleotides to be of lower than 40% mutant allele frequency (MAF), leading to low NPA values. A study using the THxID BRAF kit (biomérieux) was conducted with samples with BRAF V600 dinucleotide mutation detected by F1CDx and BRAF V600 negative samples to provide a better evaluation of V600 dinucleotide concordance. FoundationOne CDx is concordant with other next-generation sequencing (NGS) methods FoundationOne CDx is concordant with FoundationOne POSITIVE-PERCENT AGREEMENT (PPA*) NEGATIVE-PERCENT AGREEMENT (NPA*) POSITIVE-PERCENT AGREEMENT (PPA) NEGATIVE-PERCENT AGREEMENT (NPA) All short variants 94.6% 99.9% Substitutions 96.6% 99.9% Indels 83.4% 99.9% The detection of alterations by FoundationOne CDx assay was compared to results of an externally validated NGS assay (evngs). Overall there were 157 overlapping genes between the two assays. The comparison between short alterations, including base substitutions and short indels, detected by F1CDx and the orthogonal method included 188 samples from 46 different tumors. Differences in variants of unknown significance (VUS) alteration calls between the platform were noted, and are expected based on differences in filtering employed by F1CDx and evngs. Negative predictive value and positive predictive value were also calculated and were found to be different than percent agreement because the two platforms filter VUS differently. Discordant alterations not related to VUS filtering were primarily caused by deletions with low allelic fraction in homopolymer regions. The F1CDx variant calling pipeline imposes a filter based on MAF of 0.10 for indels in homopolymer regions to reduce the likelihood of calling false positives resulting from artifacts introduced by the technology. As such, the difference observed was due to varying filter thresholds between the two platforms. *The PPA and NPA were calculated without adjusting for the distribution of samples enrolled using the FoundationOne Laboratory-Developed Test (F1 LDT), therefore these estimates may be biased upward. All variants 98.6% 99.9% All short variants 99.1% 99.9% Substitutions 99.4% 99.9% Indels 97.0% 99.9% All CNV 94.3% 99.9% Amplifications 94.0% 99.9% Losses 94.8% 99.8% Rearrangements 100.0% 99.9% This study evaluated a test set of 165 specimens. PPA and NPA between the F1CDx and F1 LDT, using the F1 assay as the reference method, was calculated for all alterations, as well as for alterations binned by type: short variants, copy number alterations (CNAs) and rearrangements. A total of 2325 variants, including 2026 short variants, 266 copy number alterations and 33 rearrangements were included in the study.

4 Comprehensive genomic profiling can identi more options for patients The approach used by FoundationOne CDx has been shown by our FoundationOne assay to identify more patients, compared with traditional single-gene testing methods, who test positive for genomic alterations in several cancer types. Non-Small Cell Lung Cancer (NSCLC) Simplifies the practice of guidelines-based medicine in NSCLC by including all guideline-recommended genes and offering results on MSI and TMB to help inform decisions on immunotherapy with one comprehensive test Comprehensive genomic profiling can identify up to 35% and 17% more patients with ALK fusions and EGFR alterations, respectively, compared with traditional FISH and PCR-based methods 1 2 FoundationOne CDx can identify resistance mechanisms and important negative results that can be used for patient management Identifies patients with BRAF V600E alterations who may benefit from therapy Colorectal Cancer (CRC) Comprehensive genomic profiling can identify up to 12% more patients with resistant KRAS alterations compared with traditional PCR-based methods 3 Identifies resistant NRAS alterations that can be used for patient management Identifies alterations such as BRAF and ERBB2 that can be used for patient management Breast Cancer FoundationOne CDx can identify patients with ERBB2 alterations who may benefit from HER2 therapy Detects drug resistance mechanisms, including diverse ESR1 alterations that may inform patient management regarding hormone therapy and various RB1 alterations that may inform patient management regarding CDK4/6 inhibitors Melanoma Comprehensive genomic profiling can identify up to 37% more patients with important BRAF alterations compared with traditional PCR-based methods 4 Up to 40% of melanoma patients are TMB-High and have been shown to respond to immunotherapies 5 Detects resistance mechanisms such as NRAS and MEK1 that may inform patient management Ovarian Cancer FoundationOne CDx can identify patients with germline (inherited) or somatic (not inherited) BRCA1/2 alterations who may benefit from PARP inhibitors current testing methods often look only for germline alterations and may not identify up to 50% of patients who have somatic alterations* * FoundationOne CDx does not distinguish between germline and somatic alterations. ALL OTHER SOLID-TUMOR CANCERS FoundationOne CDx uses a comprehensive approach across 324 genes to provide cancer-relevant alterations that may inform treatment management in accordance with professional guidelines. COMPREHENSIVE SUPPORT SERVICES FOR CLINICAL TRIALS Clinical trials, which are listed based on genomic alterations (provided as a professional service) and many are supported by Precision Enrollment, which identifies patients with rare or specific biomarkers, such as NTRK fusions, and matches them with sponsor trials using our SmartTrials engine.

5 Go beyond PD-L1 for immunotherapy decisions FoundationOne CDx provides MSI and TMB on every test, and PD-L1 by IHC can be ordered as supplemental test. Patients across cancer types may test positive for any one of three biomarkers (MSI, TMB, PD-L1), which may help inform immunotherapy decisions* TMB may help inform immunotherapy decisions for patients who are negative for PD-L1 by IHC High TMB status has been found in patients across cancer types MSI may inform eligibility for immunotherapies, which are approved for metastatic cancer patients with MSI-High or mismatch-repair deficient (dmmr) solid tumors PD-L1 by IHC can be ordered as a supplemental test and may inform eligibility for several immunotherapies across many different cancer types * Data based on Foundation Medicine experience. Goodman et al, Tumor Mutational Burden as an independent predictor of response to immunotherapy in diverse cancers. AACR Aug FDA website: ucm htm. There is no companion diagnostic test identified and approved by the FDA for MSI and pembrolizumab. 14 % of patients who test negative for PD-L1 by IHC have MSI-High or TMB-High status, which may help inform immunotherapy decisions*

6 About Foundation Medicine Foundation Medicine is a world-leading molecular insights company offering a suite of testing and support services to connect physicians and their patients to the latest cancer treatment approaches and making precision medicine a reality for thousands. For more information, please visit foundationmedicine.com or follow us on Twitter (@FoundationATCG). TO LEARN MORE: Visit TO ORDER: Available to order in early 2018 References 1. Drilon A, Wang L, Arcila ME, et al. Broad, hybrid capture-based next-generation sequencing identifies actionable genomic alterations in lung adenocarcinomas otherwise negative for such alterations by other genomic testing. Clin Cancer Res. 2015;21(16): Ali SM, Hensing T, Schrock AB, et al. Comprehensive genomic profiling identifies a subset of crizotinib-responsive ALK-rearranged non-small cell lung cancer not detected by fluorescence in situ hybridization. Oncologist. 2016;21(6): Rankin A, Klempner SJ, Erlich R, et al. Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer. The Oncologist Boussemart et al. Hybrid-capture based genomic profiling identifies BRAF V600 and non-v600 alterations in melanoma samples negative by prior testing. ESMO DB Johnson et al, Cancer Immunology Research FoundationOne CDx is a next-generation sequencing based in vitro diagnostic device for detection of substitutions, insertion and deletion alterations, and copy number alterations in 324 genes and select gene rearrangements, as well as genomic signatures including microsatellite instability (MSI) and tumor mutational burden (TMB) using DNA isolated from formalin-fixed, paraffin-embedded (FFPE) tumor tissue specimens. For the complete intended use statement, including companion diagnostic indications, please see the FoundationOne CDx Technical Information, Foundation Medicine, Inc. FoundationOne CDx is a trademark of Foundation Medicine, Inc. Tel Fax MKT

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