4Hellenic & Bulgarian

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1 Organized by: Hellenic and International Society of Molecular Targeted and Personalized Treatments (H.I.S.M.T.P.T.) Young Oncologist Club Bulgaria Under the auspice of: Hellenic Society of Medical Oncology Hellenic Society of Radiation Oncology Hellenic Society of Oral Oncology AKOS ΤΑΤ 5-6 MAY H O T E L DIVANI APOLLON A T H E N S 12 CME CPD points, Panhellenic Medical Association TAT 2017 THE HOME OF PHASE I IN ONCOLOGY th with the subject: Immuno-Targeted therapies in solid hematological malignancies & the Highlights of the 15 th TAT 2017 SCIENTIFIC PROGRAM

2 5-6 MAY th Invitation letter The Hellenic and International Society of Molecular-Targeted-Personalized Treatments and the Young Oncology Club-Bulgaria co-organise their 4 th with the subject: «Immuno-Targeted therapies in solid and hematological malignancies» Rossitza Krasteva Ruseva, the President and her colleagues from Bulgaria, will present their experience -concerning the immuno-targeted therapiesin the field of basic research and clinical practice. Dr. Vassili Soumelis from Curie Institute, Paris will present the recent data on immunotherapy and cancer. The Professors in Medical-Oncology Dr. Giuseppe Giaccone (Georgetown University Washington DC, USA), and Jean-Pierre Armand (Institute Gustave Roussy, Paris) gave us the auspices to report the «highlights» from the 15 th ΤΑΤ (Targeted Anticancer Therapies) which was held in Paris (6-8 March 2017). The «ΤΑΤ» is taking place one year in USA (Washington DC) and the other year in Europe(Paris) and presents all the International phase-i studies of the new molecules (immuno-targeted therapies in solid and hematological malignancies). It is a great honor for our Societies to Co-organize the 4 th Hellenic-Bulgarian under the auspice of the TAT, and to report the highlights of «TAT 2017» from Paris in our. We welcome all of you in Kavouri - Athens - and wishing a fruitful ' attendance. The Presidents of the Organizing Committee Georgios Fotios Samelis ΜD President of the Hellenic-International Society Molecular-Targeted - Personalized Treatments Rossitza Krasteva Ruseva Head of Medical Oncology Clinic Panagyuritsa Chairman of Young Oncologist Club Bulgaria 2

3 with the subject: Immuno-Targeted therapies in solid hematological malignancies & the Highlights of the 15 th TAT 2017 SCIENTIFIC PROGRAM Friday 5 TH May :00-11:00 R e g i s t r a t i o n s 11:00-12:00 Immuno-Targeted Therapies in Hematological Malignancies Chair: Ι. Adamopoulos, Ch. Poziopoulos, K. Konstantopoulos 11:00-11:20 Targeted therapy with monoclonal antibodies T. Vassilakopoulos 11:20-11:40 Targeted therapy with small molecules P. Tsirigotis 11:40-12:00 Targeted cellular therapy A. Spyridonidis 12:00-13:00 Biomedical Research and Expertise Chair: G. Nasioulas, I. Drikos, S. Kosmidis 12:00-12:20 Molecular mechanism in genetic alterations and biomarkers of response in targeted drugs 12:20-12:40 Targeted the molecular pathway under the genomic profile of each patient 12:40-13:00 The evaluation of EGFR, ALK, K RAS, B RAF status in daily clinical therapeutic practice I. Drikos G. Nasioulas Ε. Maragouli 13:00-14:30 B r e a k 14:30-15:30 Oral Complications in Patients, who Receive Targeted Therapies Chair: O. Nicolatou Galitis 14:30-14:40 Case Report E. Vardas 14:40-14:50 Case Report E. Papadopoulou 14:50-15:00 Case Report M. Kouri 15:00-15:10 Case Report X. Chatzihalepli 15:10-15:20 Case Report A. Vourli 15:20-15:30 Discussion 3 H O T E L DIVANI APOLLON ATHENS

4 5-6 MAY th 15:30-16:30 Immuno-Targeted Therapies in Kidney Cancer Chair: E. Michailakis, P. Ginopoulos, S. Gouvalis 15:30-15:50 Molecular mechanisms involved in kidney cancer carcinogenesis V. Melikoki 15:50-16:10 Molecular targeted therapies and therapeutic algorithm of administration (Sunitinib, Axitinib, Pazopanib, Everolimus, Nivolumab, etc) G. Lainakis 16:10-16:30 Immunotherapy in kidney cancer N. Tsoukalas 16:30-17:45 Immuno-Targeted Therapies in Prostate Cancer Chair: A. Rebelakos, D. Katsochi, G. Aravantinos 16:30-16:50 Molecular mechanisms involved in prostate cancer carcinogenesis Α. Dimitriadou 16:50-17:10 Radiotherapy at stage B C M. Trichas 17:10-17:30 Targeted therapies in hormone refractory prostate cancer (Abiraterone Acetate, Cabazitaxel, Enzalutamide, immunotherapy?) S. Demiri 17:30-17:45 Targeting osteoblastic metastases from the point of view of the Nuclear Medicine approaches (Radioactive Samarium 153, Radium 223, etc) V. Valsamaki 17:45-18:00 C o f f e e B r e a k 18:00-20:00 Young Oncology Club-Bulgaria: Precision Medicine-Bulgarian Experience Chair: R. Krasteva 18:00-18:15 Beyond gene tests-advanced capabilities of molecular diagnostics B. Petrov 18:15-18:30 Immunotherapy - New approach for the treatment of solid tumors-bulgarian experience A. Petrova/ T. Lubomirova 18:30-18:45 New opportunities for personalized treatment for lung cancer N. Chilingirova 18:45-19:00 New opportunities for personalized treatment for breast cancer M. Koleva/ R. Krasteva 19:00-19:15 Quality of life in women undergoing hormone therapy with early breast cancer R. Krasteva 19:15-19:30 Clinical experience in Her-2 positive breast cancer P. Balikova 19:30-19:45 Personalized treatment for primary multiplicity H. Spasov 19:45-20:00 Discussion 4

5 with the subject: Immuno-Targeted therapies in solid hematological malignancies & the Highlights of the 15 th TAT :00-20:30 C o f f e e B r e a k 20:30-21:00 Opening Ceremony/ Welcome Addresses D. Katsochi President of AKOS, Radiation Oncologist O. Nikolatou Galitis President of the Hellenic Society of Oral Oncology X. Vakalis On behalf of the Hellenic Society for Radiation Oncology G. Aravantinos Vice President of the Hellenic Society of Medical Oncology G. Zografos Honorary Members s Representative, Professor of Surgery, Director of the 1 st Surgical Department, University of Athens, President of the Scientific Committee R. Krasteva Head of Medical Oncology Clinic 100 «G.Benkovski» str. Panagyurishte Bulgaria Chairman of Young Oncologist Club Bulgaria G. F. Samelis President of the Organizing Committee, President of the H.I.S.M.T.P.T. 21:00-21:30 Opening Ceremony Honorary Keynote Lecture Chair: V. Georgoulias, G. Samelis Immunotherapy and cancer Prof. V. Soumelis 21:30-23:00 Welcome Reception 5 H O T E L DIVANI APOLLON ATHENS

6 5-6 MAY th Saturday 6 TH May :30-09:00 R e g i s t r a t i o n s 09:00-10:00 Immuno-Targeted Therapies in Melanoma Chair: K. Fragia, S. Papadopoulos. 09:00-09:20 Immunotherapy (immune check point inhibitors) in metastatic disease 09:20-09:40 Targeted drugs after resistance effect in metastatic melanoma (Dobrafenib, Imatinib, Dasatinib, Nilatinib etc) 09:40-10:00 Treatment of dermatological toxicity from targeted therapies (EGFR, TΚ inhibitor, Vemurafenib Ipillimumab) F. Stavridi M. Tsigaridas M. Politou 10:00-11:00 Immuno-Targeted Therapies in Lung Cancer Chair: Ε. Samantas, X. Vakalis, M. Vaslamatzis 10:00-10:20 ALK +disease: 1st, 2nd, 3rd line treatments M. Nikolaou 10:20-10:40 Targeted the KRAS, ΕGFR, ALK, BRAF, ROS pathways Sp. Papanikolaou 10:40-11:00 The present-future of immunotherapy in Lung cancer N. Kentepozidis 11:00-11:30 C o f f e e B r e a k 11:30-12:30 Immuno-Targeted Therapies in Breast Cancer (A) Chair: G. Zografos 11:30-11:50 Targeted lumpectomy or targeted mastectomy N. Michalopoulos 11:50-12:10 Targeted Therapies in triple negative metastatic disease M. Theohari 12:10-12:30 New options of immunotherapy in breast cancer A. Tzovaras 12:30-13:30 Immuno-Targeted Therapies in Breast Cancer (B) Chair: V. Barbounis, S. Kosmidis, A. Ardavanis 12:30-12:50 Diagnostic approaches via classical or digital mammography A. Nikita 12:50-13:10 mirnas in breast cancer D. Kalapanida 13:10-13:30 Targeted therapies in metastatic breast cancer (CDK4/6, P13K/AKT/mTOR inhibitors, Nab Paclitaxel,erubilin) F. Zagouri 13:30-14:00 Lecture Chair: P. Μakrantonakis, F. Zagouri The role of Trabedectin in gynecological cancer D. Tzaninis 6

7 with the subject: Immuno-Targeted therapies in solid hematological malignancies & the Highlights of the 15 th TAT :00-15:30 L u n c h B r e a k 15:30 16:30 Oral Presentations for Selected Posters for Awards Chair: S. Volteas, Th. Giannaros, K. Ekmektzoglou 16:30-18:00 Targeted Therapies in Gastrointestinal Cancers Chair: P. Papakostas, Μ. Konstantoulakis, Z. Kafiri 16:30-16:50 Molecular basis of carcinogenesis in gastrointestinal tumors Κ. Ekmektzoglou 16:50-17:10 Whipple operation in pancreatic cancer (state of the art) Κ. Bramis 17:10-17:30 Targeted therapies in left and right colon cancers through Kras, Nras, Braf status and the sequence of administration E. Galani 17:30-18:00 Targeted therapies in stomach and pancreatic cancers (Teysuno, Herceptin,ramucirumab,nab paclitaxel, etc) Th.Tegos 18:00-18:30 C o f f e e B r e a k 18:30-19:30 The Highlights of the 15 th TAT 2017 (Paris 6-8 March 2017) Chair: J.P. Armand, G. Giaccone, G. Samelis 18:30-18:50 G. Giaccone Georgetown University Washington DC 18:50-19:10 J.P. Armand Institute Gustave Roussy Paris 19:10-19:30 Discussion 19:30-20:00 Closing Ceremony Honorary Lecture Chair: G. Samelis, G. Aravantinos Novel Treatments in Lung Cancer 20:30 End of the 7 Prof. G. Giaccone H O T E L DIVANI APOLLON ATHENS

8 th General informations with the subject: Immuno-Targeted therapies in solid hematological malignancies & the Highlights of the 15 th TAT 2017 Organized by Hellenic and International Society of Molecular Targeted - Personalized Treatments (H.I.S.M.T.P.T.) Young Oncologist Club Bulgaria Under the auspice of Dates May 5th & 6th, 2017 Venue Divani Apollon Hotel Ag. Nikolaou 10, Vouliagmeni, Athens, , Greece, Tel Language The official language of the congress is English. Registration No Registration fees applied Certificate of Attendance All registered participants who have attended at least 60% of the total scientific program will receive a certificate of attendance from the secretariat desk after the closing ceremony. Secretariat E.T.S. Events & Travel Solutions S.A. 154 El. Venizelou Str N. Smirni, Athens-Greece Tel: , Fax: ets@otenet.gr ets@events.gr Website: 8